NCR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)9.24806291
2positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)8.58494018
3regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)7.73289882
4positive regulation of interleukin-17 production (GO:0032740)7.13619311
5ADP metabolic process (GO:0046031)7.03877676
6positive regulation of osteoclast differentiation (GO:0045672)6.97162176
7positive regulation of cell fate commitment (GO:0010455)6.93154170
8negative regulation of interleukin-10 production (GO:0032693)6.91411573
9positive regulation of defense response to virus by host (GO:0002230)6.77673346
10regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)6.68831214
11positive regulation of T-helper 1 type immune response (GO:0002827)6.46115990
12positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.34947305
13cellular response to interleukin-15 (GO:0071350)6.22479368
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.16212582
15negative regulation of cell killing (GO:0031342)6.16212582
16regulation of monocyte differentiation (GO:0045655)6.08268044
17regulation of T cell mediated cytotoxicity (GO:0001914)6.04107869
18positive regulation of T cell mediated cytotoxicity (GO:0001916)6.01918282
19positive regulation of T-helper cell differentiation (GO:0045624)5.81294166
20natural killer cell activation involved in immune response (GO:0002323)5.60687691
21hair cycle (GO:0042633)5.51705354
22molting cycle (GO:0042303)5.51705354
23deoxyribonucleoside diphosphate metabolic process (GO:0009186)5.48313758
24regulation of T-helper 1 type immune response (GO:0002825)5.43250408
25regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.37039549
26positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)5.05714871
27response to interleukin-15 (GO:0070672)5.02332561
28positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.66440425
29negative regulation of protein autophosphorylation (GO:0031953)4.62839659
30purine deoxyribonucleotide metabolic process (GO:0009151)4.60034316
31purine ribonucleoside diphosphate metabolic process (GO:0009179)4.59906334
32purine nucleoside diphosphate metabolic process (GO:0009135)4.59906334
33regulation of T-helper cell differentiation (GO:0045622)4.55744524
34regulation of defense response to virus by host (GO:0050691)4.50401439
35regulation of leukocyte mediated cytotoxicity (GO:0001910)4.44903857
36regulation of interleukin-17 production (GO:0032660)4.43750650
37regulation of interleukin-12 biosynthetic process (GO:0045075)4.39533617
38purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.38051455
39mast cell activation (GO:0045576)4.36603289
40positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.28966060
41positive regulation of T cell mediated immunity (GO:0002711)4.24227218
42cellular response to nicotine (GO:0071316)4.20644375
43mast cell activation involved in immune response (GO:0002279)4.16959516
44mast cell degranulation (GO:0043303)4.16959516
45leukocyte degranulation (GO:0043299)4.07823980
46positive regulation of activated T cell proliferation (GO:0042104)4.07311832
47regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.06636583
48regulation of cell killing (GO:0031341)4.03507033
49tumor necrosis factor-mediated signaling pathway (GO:0033209)3.98768036
50positive regulation of cell killing (GO:0031343)3.91128898
51regulation of T cell mediated immunity (GO:0002709)3.88413103
52regulation of germinal center formation (GO:0002634)3.76924981
53regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.75352201
54sleep (GO:0030431)3.75090553
55ribonucleoside diphosphate metabolic process (GO:0009185)3.73599193
56negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.68710595
57regulation of natural killer cell activation (GO:0032814)3.67081454
58positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.62652651
59N-glycan processing (GO:0006491)3.59646627
60positive regulation of alpha-beta T cell differentiation (GO:0046638)3.59575983
61positive regulation of natural killer cell activation (GO:0032816)3.53474062
62AMP metabolic process (GO:0046033)3.48807792
63positive regulation of interleukin-12 production (GO:0032735)3.44180025
64negative regulation of T cell mediated immunity (GO:0002710)3.43355653
65negative regulation of mast cell activation (GO:0033004)3.38615833
66base-excision repair, AP site formation (GO:0006285)3.37822496
67cellular anion homeostasis (GO:0030002)3.37195480
68positive regulation of myeloid leukocyte differentiation (GO:0002763)3.35719426
69trivalent inorganic anion homeostasis (GO:0072506)3.33881936
70phosphate ion homeostasis (GO:0055062)3.33881936
71regulation of activated T cell proliferation (GO:0046006)3.33740250
72lymph node development (GO:0048535)3.32394564
73regulation of gamma-delta T cell differentiation (GO:0045586)3.32254727
74regulation of B cell receptor signaling pathway (GO:0050855)3.30588530
75lysosome localization (GO:0032418)3.29496016
76positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.18011563
77regulation of alpha-beta T cell differentiation (GO:0046637)3.17880272
78positive regulation of T cell cytokine production (GO:0002726)3.16033956
79natural killer cell activation (GO:0030101)3.15173675
80negative regulation of DNA-templated transcription, elongation (GO:0032785)3.14040379
81regulation of interleukin-12 production (GO:0032655)3.13236089
82regulation of interleukin-10 production (GO:0032653)3.07169823
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.07161463
84positive regulation of alpha-beta T cell activation (GO:0046635)3.03906927
85negative regulation of glycogen biosynthetic process (GO:0045719)3.02918927
86negative regulation of lymphocyte mediated immunity (GO:0002707)2.96725559
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95266189
88positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.93678400
89positive regulation of interferon-gamma production (GO:0032729)2.93394475
90positive regulation of prostaglandin secretion (GO:0032308)2.93269544
91response to muramyl dipeptide (GO:0032495)2.91663617
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91337864
93regulation of vitamin D biosynthetic process (GO:0060556)2.88466227
94cellular response to interleukin-6 (GO:0071354)2.87494559
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.86274986
96tolerance induction (GO:0002507)2.85632351
97regulation of osteoclast differentiation (GO:0045670)2.83301292
98negative regulation of leukocyte mediated immunity (GO:0002704)2.82672061
99negative T cell selection (GO:0043383)2.81288823
100regulation of memory T cell differentiation (GO:0043380)11.2322068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.04158362
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.43382006
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.31688364
4RUNX_20019798_ChIP-Seq_JUKART_Human4.26001781
5GATA1_22025678_ChIP-Seq_K562_Human3.33520008
6MYB_26560356_Chip-Seq_TH2_Human3.20905538
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.85630968
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82762312
9SCL_19346495_ChIP-Seq_HPC-7_Human2.82069267
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70898725
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.67828597
12GATA3_26560356_Chip-Seq_TH2_Human2.55259253
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.53486686
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.31774466
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30704383
16GATA3_27048872_Chip-Seq_THYMUS_Human2.24663312
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24204020
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06046189
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.05720034
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04989365
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04832281
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93103383
23* UTX_26944678_Chip-Seq_JUKART_Human1.91325578
24CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.85044275
25MYB_26560356_Chip-Seq_TH1_Human1.82672634
26MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75489488
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73302307
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70213623
29GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.69606003
30MAF_26560356_Chip-Seq_TH1_Human1.69187204
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67711747
32IRF1_19129219_ChIP-ChIP_H3396_Human1.63589634
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50232280
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.49755868
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42973281
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.42344938
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38694412
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38357855
39MAF_26560356_Chip-Seq_TH2_Human1.37409110
40TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.35556298
41SPI1_23547873_ChIP-Seq_NB4_Human1.31445485
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31126082
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27751364
44TP53_22573176_ChIP-Seq_HFKS_Human1.26217887
45TAF15_26573619_Chip-Seq_HEK293_Human1.23665131
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17644385
47BCL6_27268052_Chip-Seq_Bcells_Human1.14910407
48RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13489340
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.12570197
50MYC_22102868_ChIP-Seq_BL_Human1.12392900
51VDR_23849224_ChIP-Seq_CD4+_Human1.11172899
52P300_27268052_Chip-Seq_Bcells_Human1.11071015
53STAT1_20625510_ChIP-Seq_HELA_Human1.10329377
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.09211514
55P68_20966046_ChIP-Seq_HELA_Human1.08756505
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08534660
57MYC_19829295_ChIP-Seq_ESCs_Human1.06153757
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.05963545
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05773865
60SA1_27219007_Chip-Seq_Bcells_Human1.04055187
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03342362
62* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02627317
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00417792
64TCF4_18268006_ChIP-ChIP_LS174T_Human0.99814303
65PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98038458
66FOXA1_25329375_ChIP-Seq_VCAP_Human0.97936109
67FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97936109
68* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95277075
69OCT4_20526341_ChIP-Seq_ESCs_Human0.95196732
70VDR_24787735_ChIP-Seq_THP-1_Human0.94560223
71GATA3_26560356_Chip-Seq_TH1_Human0.93243470
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93228055
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93157844
74ER_23166858_ChIP-Seq_MCF-7_Human0.92734236
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92705798
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92453643
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92252484
78TAF2_19829295_ChIP-Seq_ESCs_Human0.92006025
79AR_20517297_ChIP-Seq_VCAP_Human0.91212496
80TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90390208
81* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90306574
82* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89730870
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.89644010
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89514425
85GATA3_21867929_ChIP-Seq_CD8_Mouse0.88829953
86SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.88716906
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88494229
88BCOR_27268052_Chip-Seq_Bcells_Human0.87838788
89VDR_24763502_ChIP-Seq_THP-1_Human0.85490434
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85046441
91* HOXB7_26014856_ChIP-Seq_BT474_Human0.84195618
92SMRT_27268052_Chip-Seq_Bcells_Human0.83594589
93PHF8_20622854_ChIP-Seq_HELA_Human0.83434676
94NANOG_20526341_ChIP-Seq_ESCs_Human0.83013384
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82040895
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.81769697
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81757164
98AR_21572438_ChIP-Seq_LNCaP_Human0.81753204
99* SPI1_20517297_ChIP-Seq_HL60_Human0.81717317
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.80717339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.13033289
2MP0005671_abnormal_response_to4.92691738
3MP0003878_abnormal_ear_physiology3.50784997
4MP0005377_hearing/vestibular/ear_phenot3.50784997
5MP0003763_abnormal_thymus_physiology3.40091156
6MP0005075_abnormal_melanosome_morpholog3.27448783
7MP0005000_abnormal_immune_tolerance3.02217084
8MP0003879_abnormal_hair_cell2.95935985
9MP0002877_abnormal_melanocyte_morpholog2.72920088
10MP0003303_peritoneal_inflammation2.71045045
11MP0001835_abnormal_antigen_presentation2.65287302
12MP0003724_increased_susceptibility_to2.54937334
13MP0009785_altered_susceptibility_to2.33082873
14MP0003866_abnormal_defecation2.28873639
15MP0002723_abnormal_immune_serum2.27280398
16MP0004885_abnormal_endolymph2.24777200
17MP0001800_abnormal_humoral_immune2.16622936
18MP0008877_abnormal_DNA_methylation2.14813066
19MP0001188_hyperpigmentation2.12861980
20MP0003436_decreased_susceptibility_to2.10741385
21MP0001819_abnormal_immune_cell2.03944703
22MP0003638_abnormal_response/metabolism_2.00756972
23MP0002420_abnormal_adaptive_immunity1.99207401
24MP0002933_joint_inflammation1.93514077
25MP0002148_abnormal_hypersensitivity_rea1.86824969
26MP0002452_abnormal_antigen_presenting1.82848139
27MP0004947_skin_inflammation1.81843955
28MP0000685_abnormal_immune_system1.79038006
29MP0002419_abnormal_innate_immunity1.72430562
30MP0001533_abnormal_skeleton_physiology1.72289891
31MP0000465_gastrointestinal_hemorrhage1.71663201
32MP0005025_abnormal_response_to1.69876453
33MP0000716_abnormal_immune_system1.63101396
34MP0000703_abnormal_thymus_morphology1.58494019
35MP0002405_respiratory_system_inflammati1.58450332
36MP0001765_abnormal_ion_homeostasis1.57905281
37MP0002398_abnormal_bone_marrow1.55313967
38MP0001790_abnormal_immune_system1.53105689
39MP0005387_immune_system_phenotype1.53105689
40MP0002998_abnormal_bone_remodeling1.52330878
41MP0002138_abnormal_hepatobiliary_system1.50290852
42MP0002722_abnormal_immune_system1.46368475
43MP0000371_diluted_coat_color1.42003548
44MP0010155_abnormal_intestine_physiology1.39563141
45MP0001501_abnormal_sleep_pattern1.37994214
46MP0000689_abnormal_spleen_morphology1.37317309
47MP0002102_abnormal_ear_morphology1.34046106
48MP0001845_abnormal_inflammatory_respons1.33716912
49MP0002736_abnormal_nociception_after1.31973131
50MP0010368_abnormal_lymphatic_system1.30778991
51MP0008872_abnormal_physiological_respon1.26123130
52MP0001502_abnormal_circadian_rhythm1.25260852
53MP0004147_increased_porphyrin_level1.25230708
54MP0004742_abnormal_vestibular_system1.25057582
55MP0002429_abnormal_blood_cell1.25054859
56MP0001851_eye_inflammation1.23907135
57MP0009278_abnormal_bone_marrow1.14389724
58MP0009333_abnormal_splenocyte_physiolog1.11697782
59MP0003300_gastrointestinal_ulcer1.09397518
60MP0001968_abnormal_touch/_nociception1.07308890
61MP0005083_abnormal_biliary_tract1.04542649
62MP0005084_abnormal_gallbladder_morpholo1.04465559
63MP0003191_abnormal_cellular_cholesterol0.99851303
64MP0009764_decreased_sensitivity_to0.94063242
65MP0008961_abnormal_basal_metabolism0.93228923
66MP0002876_abnormal_thyroid_physiology0.89585829
67MP0003828_pulmonary_edema0.86536823
68MP0005464_abnormal_platelet_physiology0.85816441
69MP0005390_skeleton_phenotype0.82863250
70MP0003795_abnormal_bone_structure0.81405029
71MP0005174_abnormal_tail_pigmentation0.79159234
72MP0005167_abnormal_blood-brain_barrier0.77979091
73MP0009763_increased_sensitivity_to0.77606777
74MP0006072_abnormal_retinal_apoptosis0.76633734
75MP0008995_early_reproductive_senescence0.75229023
76MP0003252_abnormal_bile_duct0.72909612
77MP0008469_abnormal_protein_level0.72608281
78MP0004142_abnormal_muscle_tone0.72163091
79MP0004043_abnormal_pH_regulation0.72107985
80MP0003786_premature_aging0.69332637
81MP0005076_abnormal_cell_differentiation0.68803272
82MP0003448_altered_tumor_morphology0.68492343
83MP0008873_increased_physiological_sensi0.68051208
84MP0003011_delayed_dark_adaptation0.67787284
85MP0008875_abnormal_xenobiotic_pharmacok0.67618329
86MP0001485_abnormal_pinna_reflex0.65885493
87MP0000367_abnormal_coat/_hair0.65586217
88MP0002075_abnormal_coat/hair_pigmentati0.64432128
89MP0001764_abnormal_homeostasis0.64043086
90MP0003183_abnormal_peptide_metabolism0.62730830
91MP0002272_abnormal_nervous_system0.61060648
92MP0009765_abnormal_xenobiotic_induced0.60427040
93MP0001348_abnormal_lacrimal_gland0.60295397
94MP0005165_increased_susceptibility_to0.60146758
95MP0001919_abnormal_reproductive_system0.59727110
96MP0002166_altered_tumor_susceptibility0.58909181
97MP0001873_stomach_inflammation0.58092239
98MP0001963_abnormal_hearing_physiology0.57983875
99MP0000609_abnormal_liver_physiology0.56970923
100MP0008775_abnormal_heart_ventricle0.55786861

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)9.30689856
2Retrobulbar optic neuritis (HP:0100654)9.30689856
3Orchitis (HP:0100796)8.17222495
4Myositis (HP:0100614)7.61384823
5Keratoconjunctivitis sicca (HP:0001097)6.30560398
6Keratoconjunctivitis (HP:0001096)6.05917354
7Brittle hair (HP:0002299)5.36635411
8Hypotrichosis (HP:0001006)4.58844952
9T lymphocytopenia (HP:0005403)4.58496257
10Abnormality of eosinophils (HP:0001879)4.53446090
11Renal cortical cysts (HP:0000803)4.43543912
12Severe combined immunodeficiency (HP:0004430)4.16147094
13Slow-growing hair (HP:0002217)4.12393506
14Abnormality of hair growth rate (HP:0011363)4.12393506
15Abnormality of T cell number (HP:0011839)4.01276455
16IgG deficiency (HP:0004315)3.80991211
17Arterial thrombosis (HP:0004420)3.73261634
18Hypophosphatemic rickets (HP:0004912)3.73156946
19Pulmonary infiltrates (HP:0002113)3.72253411
20Persistence of primary teeth (HP:0006335)3.62964347
21Encephalitis (HP:0002383)3.55223028
22Granulocytopenia (HP:0001913)3.47202897
23Anorexia (HP:0002039)3.46305506
24Eosinophilia (HP:0001880)3.39121048
25Gangrene (HP:0100758)3.26267253
26Combined immunodeficiency (HP:0005387)3.21353644
27Vertigo (HP:0002321)3.16359029
28Vasculitis (HP:0002633)3.08327064
29Hemoptysis (HP:0002105)3.01735833
30Abnormality of T cells (HP:0002843)2.99683897
31Polyneuropathy (HP:0001271)2.96611541
32Gastrointestinal stroma tumor (HP:0100723)2.88381490
33Abnormality of the renal cortex (HP:0011035)2.87490261
34Keratitis (HP:0000491)2.86691343
35Flat capital femoral epiphysis (HP:0003370)2.83888535
36Leukocytosis (HP:0001974)2.81953441
37Pulmonary embolism (HP:0002204)2.78090845
38Conical tooth (HP:0000698)2.72944088
39Neoplasm of head and neck (HP:0012288)2.71108725
40Esophageal neoplasm (HP:0100751)2.71108725
41Stomach cancer (HP:0012126)2.66175886
42Thyroiditis (HP:0100646)2.56513067
43Glomerulopathy (HP:0100820)2.55934601
44Pancreatitis (HP:0001733)2.51427243
45Delayed CNS myelination (HP:0002188)2.47973802
46Anhidrosis (HP:0000970)2.47516201
47Nephronophthisis (HP:0000090)2.43211873
48Thrombophlebitis (HP:0004418)2.38338029
49Abnormality of dental color (HP:0011073)2.37851037
50Adactyly (HP:0009776)2.33686624
51Acne (HP:0001061)2.31271045
52Pustule (HP:0200039)2.28104678
53Hypophosphatemia (HP:0002148)2.27646652
54Premature loss of primary teeth (HP:0006323)2.26670703
55Joint swelling (HP:0001386)2.21026264
56Tongue fasciculations (HP:0001308)2.20545357
57Abnormality of the pleura (HP:0002103)2.18896082
58Type II lissencephaly (HP:0007260)2.18426586
59Eczematoid dermatitis (HP:0000976)2.14924094
60Short tibia (HP:0005736)2.14479232
61Abnormality of the proximal phalanges of the hand (HP:0009834)2.11601975
62Muscle fibrillation (HP:0010546)2.10507481
63Papilledema (HP:0001085)2.07801893
64Arthralgia (HP:0002829)2.05667005
65Elevated erythrocyte sedimentation rate (HP:0003565)2.05489962
66Abnormality of the pericardium (HP:0001697)2.03567863
67Vascular calcification (HP:0004934)2.02599212
68Porencephaly (HP:0002132)1.96455687
69Abolished electroretinogram (ERG) (HP:0000550)1.94951351
70Increased IgE level (HP:0003212)1.94649508
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.93283987
72Abnormality of the endocardium (HP:0004306)1.90836699
73Pulmonary fibrosis (HP:0002206)1.90523699
74Nail dystrophy (HP:0008404)1.90522024
75Meningitis (HP:0001287)1.89209767
76Clumsiness (HP:0002312)1.86025434
77Flattened epiphyses (HP:0003071)1.84001938
78Stomatitis (HP:0010280)1.83179379
79Hypoplasia of the thymus (HP:0000778)1.82700464
80Hypoplasia of the pons (HP:0012110)1.82419519
81Tinnitus (HP:0000360)1.81058255
82Abnormality of T cell physiology (HP:0011840)1.79746711
83Fine hair (HP:0002213)1.79605661
84Congenital stationary night blindness (HP:0007642)1.79316684
85Abnormality of the pons (HP:0007361)1.78139325
86Abnormality of the renal medulla (HP:0100957)1.75859595
87Prostate neoplasm (HP:0100787)1.75703824
88Abnormality of intracranial pressure (HP:0012640)1.75508037
89Increased intracranial pressure (HP:0002516)1.75508037
90Pancreatic cysts (HP:0001737)1.74728412
91Cardiovascular calcification (HP:0011915)1.74085308
92Alveolar cell carcinoma (HP:0006519)1.73964888
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72527780
94Spinal cord lesions (HP:0100561)1.69685746
95Syringomyelia (HP:0003396)1.69685746
96Facial diplegia (HP:0001349)1.64529695
97Increased density of long bones (HP:0006392)1.64435915
98Mediastinal lymphadenopathy (HP:0100721)1.63606766
99Brushfield spots (HP:0001088)1.62666260
100Recurrent bronchitis (HP:0002837)1.62655178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA34.90985098
2MAP4K24.77646908
3TXK4.45517018
4MAP3K144.14880584
5GRK63.72522438
6MUSK3.04281944
7TAOK32.73838324
8JAK12.53484178
9EPHB12.48747077
10SIK32.42159095
11IKBKE2.30225710
12IKBKB2.14204196
13KIT2.08880921
14TBK12.07541466
15ZAK1.94557989
16MAP2K21.83273136
17IRAK11.72668699
18FES1.72014020
19ARAF1.70589458
20TLK11.68956913
21BRD41.62830173
22FGFR41.62661990
23BCKDK1.57442576
24CHUK1.55712531
25MATK1.49508023
26TESK21.49324358
27KDR1.39094210
28MAP4K11.25168103
29GRK11.23762647
30PIM21.22155509
31BMPR21.20292408
32IRAK41.20102044
33CLK11.13955963
34LCK1.08965907
35PRKCQ1.07290690
36FER1.05402457
37RIPK41.00560692
38EIF2AK20.96346367
39CDK190.95848564
40ADRBK20.90104814
41NLK0.87188072
42ERN10.86277101
43FGFR30.84801184
44ZAP700.82714523
45PIM10.82432970
46CSK0.79690971
47TIE10.79334724
48MARK30.79334487
49RPS6KA50.77823357
50OXSR10.77458085
51HCK0.76445821
52LYN0.73563974
53IGF1R0.72484534
54PRKCH0.71888067
55NEK60.71615641
56MST40.71492575
57SYK0.64102495
58SIK20.63271300
59MAPK110.60770272
60INSR0.59549737
61MAPKAPK20.59265704
62CDK30.57992961
63MAPK150.57132813
64PHKG10.51405755
65PHKG20.51405755
66BTK0.48253222
67CSNK1A1L0.45844506
68NEK10.44794364
69EGFR0.43358381
70RAF10.42871339
71CSNK1G30.41649170
72PRKCI0.41046359
73PDK10.40379288
74JAK30.39921915
75MAPK70.39473713
76PIK3CA0.38314568
77MAP3K40.38130203
78STK40.37983101
79CDK40.37371658
80PIK3CG0.36738120
81CSNK1G20.35543078
82JAK20.35152820
83HIPK20.34421845
84STK380.30517214
85FYN0.29611497
86VRK10.29234332
87CSF1R0.28856190
88MET0.26342175
89RPS6KA10.26230233
90LIMK10.25853299
91NUAK10.24223130
92TYK20.22139040
93SRPK10.21261873
94RPS6KA40.20805864
95RPS6KA20.20487936
96ABL10.20176910
97MAPK30.19940609
98PINK10.19108140
99RPS6KA60.18595298
100CDK60.17372647

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.04062443
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.52786483
3Primary immunodeficiency_Homo sapiens_hsa053403.18914246
4* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.09068800
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.84921728
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.72488622
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.66171542
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.54055283
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.49914821
10Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.32414706
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25089091
12T cell receptor signaling pathway_Homo sapiens_hsa046602.22897269
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.21455269
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.08970477
15Jak-STAT signaling pathway_Homo sapiens_hsa046302.08838126
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.79790040
17Measles_Homo sapiens_hsa051621.72531605
18Graft-versus-host disease_Homo sapiens_hsa053321.69563362
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.63329101
20B cell receptor signaling pathway_Homo sapiens_hsa046621.61931795
21Herpes simplex infection_Homo sapiens_hsa051681.61517839
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59186090
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56025112
24Osteoclast differentiation_Homo sapiens_hsa043801.55774748
25Linoleic acid metabolism_Homo sapiens_hsa005911.52681260
26Acute myeloid leukemia_Homo sapiens_hsa052211.51303695
27Shigellosis_Homo sapiens_hsa051311.45872225
28Sulfur metabolism_Homo sapiens_hsa009201.34634511
29Leishmaniasis_Homo sapiens_hsa051401.32940294
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31300201
31Arachidonic acid metabolism_Homo sapiens_hsa005901.25212426
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25004333
33Hematopoietic cell lineage_Homo sapiens_hsa046401.23946542
34Antigen processing and presentation_Homo sapiens_hsa046121.20493505
35Phototransduction_Homo sapiens_hsa047441.18758829
36Legionellosis_Homo sapiens_hsa051341.10816047
37Malaria_Homo sapiens_hsa051441.09089131
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08254290
39TNF signaling pathway_Homo sapiens_hsa046681.08163049
40Caffeine metabolism_Homo sapiens_hsa002320.99815948
41Peroxisome_Homo sapiens_hsa041460.95230713
42Adipocytokine signaling pathway_Homo sapiens_hsa049200.93515458
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90266461
44Vitamin digestion and absorption_Homo sapiens_hsa049770.90049216
45Hepatitis C_Homo sapiens_hsa051600.77527859
46Hepatitis B_Homo sapiens_hsa051610.77192093
47Tryptophan metabolism_Homo sapiens_hsa003800.76059495
48Rheumatoid arthritis_Homo sapiens_hsa053230.75942722
49Phenylalanine metabolism_Homo sapiens_hsa003600.75831703
50ABC transporters_Homo sapiens_hsa020100.73642991
51Apoptosis_Homo sapiens_hsa042100.73503203
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73031193
53Pertussis_Homo sapiens_hsa051330.72750278
54Asthma_Homo sapiens_hsa053100.70087092
55Renin-angiotensin system_Homo sapiens_hsa046140.69522122
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.65670060
57One carbon pool by folate_Homo sapiens_hsa006700.65588880
58Circadian rhythm_Homo sapiens_hsa047100.62335846
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.61802374
60Toxoplasmosis_Homo sapiens_hsa051450.61779205
61Tyrosine metabolism_Homo sapiens_hsa003500.61217981
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60904874
63Influenza A_Homo sapiens_hsa051640.60383213
64Propanoate metabolism_Homo sapiens_hsa006400.59844528
65Prolactin signaling pathway_Homo sapiens_hsa049170.59153076
66N-Glycan biosynthesis_Homo sapiens_hsa005100.59094077
67Small cell lung cancer_Homo sapiens_hsa052220.59066252
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55539178
69Fatty acid elongation_Homo sapiens_hsa000620.54869234
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54018130
71Viral carcinogenesis_Homo sapiens_hsa052030.53108874
72Lysosome_Homo sapiens_hsa041420.48688762
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47968665
74Allograft rejection_Homo sapiens_hsa053300.43542923
75Chemokine signaling pathway_Homo sapiens_hsa040620.41431047
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41069423
77Tuberculosis_Homo sapiens_hsa051520.38882804
78Purine metabolism_Homo sapiens_hsa002300.38699899
79Autoimmune thyroid disease_Homo sapiens_hsa053200.38306431
80Retinol metabolism_Homo sapiens_hsa008300.36699714
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33650694
82Pyrimidine metabolism_Homo sapiens_hsa002400.33398561
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.32352009
84Epstein-Barr virus infection_Homo sapiens_hsa051690.30130494
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29610814
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28167884
87Taste transduction_Homo sapiens_hsa047420.27835519
88Base excision repair_Homo sapiens_hsa034100.25336993
89HTLV-I infection_Homo sapiens_hsa051660.24790700
90Ovarian steroidogenesis_Homo sapiens_hsa049130.24774416
91Selenocompound metabolism_Homo sapiens_hsa004500.24101893
92Ether lipid metabolism_Homo sapiens_hsa005650.22575690
93Nitrogen metabolism_Homo sapiens_hsa009100.21514860
94RNA degradation_Homo sapiens_hsa030180.21513646
95Fat digestion and absorption_Homo sapiens_hsa049750.20424773
96Nicotine addiction_Homo sapiens_hsa050330.19779839
97Sphingolipid metabolism_Homo sapiens_hsa006000.19552959
98Olfactory transduction_Homo sapiens_hsa047400.19499013
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.18313444
100Type I diabetes mellitus_Homo sapiens_hsa049400.18083792

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