

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of activation of Janus kinase activity (GO:0010533) | 9.24806291 |
| 2 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 8.58494018 |
| 3 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 7.73289882 |
| 4 | positive regulation of interleukin-17 production (GO:0032740) | 7.13619311 |
| 5 | ADP metabolic process (GO:0046031) | 7.03877676 |
| 6 | positive regulation of osteoclast differentiation (GO:0045672) | 6.97162176 |
| 7 | positive regulation of cell fate commitment (GO:0010455) | 6.93154170 |
| 8 | negative regulation of interleukin-10 production (GO:0032693) | 6.91411573 |
| 9 | positive regulation of defense response to virus by host (GO:0002230) | 6.77673346 |
| 10 | regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510) | 6.68831214 |
| 11 | positive regulation of T-helper 1 type immune response (GO:0002827) | 6.46115990 |
| 12 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 6.34947305 |
| 13 | cellular response to interleukin-15 (GO:0071350) | 6.22479368 |
| 14 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.16212582 |
| 15 | negative regulation of cell killing (GO:0031342) | 6.16212582 |
| 16 | regulation of monocyte differentiation (GO:0045655) | 6.08268044 |
| 17 | regulation of T cell mediated cytotoxicity (GO:0001914) | 6.04107869 |
| 18 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 6.01918282 |
| 19 | positive regulation of T-helper cell differentiation (GO:0045624) | 5.81294166 |
| 20 | natural killer cell activation involved in immune response (GO:0002323) | 5.60687691 |
| 21 | hair cycle (GO:0042633) | 5.51705354 |
| 22 | molting cycle (GO:0042303) | 5.51705354 |
| 23 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 5.48313758 |
| 24 | regulation of T-helper 1 type immune response (GO:0002825) | 5.43250408 |
| 25 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 5.37039549 |
| 26 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 5.05714871 |
| 27 | response to interleukin-15 (GO:0070672) | 5.02332561 |
| 28 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 4.66440425 |
| 29 | negative regulation of protein autophosphorylation (GO:0031953) | 4.62839659 |
| 30 | purine deoxyribonucleotide metabolic process (GO:0009151) | 4.60034316 |
| 31 | purine ribonucleoside diphosphate metabolic process (GO:0009179) | 4.59906334 |
| 32 | purine nucleoside diphosphate metabolic process (GO:0009135) | 4.59906334 |
| 33 | regulation of T-helper cell differentiation (GO:0045622) | 4.55744524 |
| 34 | regulation of defense response to virus by host (GO:0050691) | 4.50401439 |
| 35 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 4.44903857 |
| 36 | regulation of interleukin-17 production (GO:0032660) | 4.43750650 |
| 37 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.39533617 |
| 38 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 4.38051455 |
| 39 | mast cell activation (GO:0045576) | 4.36603289 |
| 40 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 4.28966060 |
| 41 | positive regulation of T cell mediated immunity (GO:0002711) | 4.24227218 |
| 42 | cellular response to nicotine (GO:0071316) | 4.20644375 |
| 43 | mast cell activation involved in immune response (GO:0002279) | 4.16959516 |
| 44 | mast cell degranulation (GO:0043303) | 4.16959516 |
| 45 | leukocyte degranulation (GO:0043299) | 4.07823980 |
| 46 | positive regulation of activated T cell proliferation (GO:0042104) | 4.07311832 |
| 47 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 4.06636583 |
| 48 | regulation of cell killing (GO:0031341) | 4.03507033 |
| 49 | tumor necrosis factor-mediated signaling pathway (GO:0033209) | 3.98768036 |
| 50 | positive regulation of cell killing (GO:0031343) | 3.91128898 |
| 51 | regulation of T cell mediated immunity (GO:0002709) | 3.88413103 |
| 52 | regulation of germinal center formation (GO:0002634) | 3.76924981 |
| 53 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 3.75352201 |
| 54 | sleep (GO:0030431) | 3.75090553 |
| 55 | ribonucleoside diphosphate metabolic process (GO:0009185) | 3.73599193 |
| 56 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 3.68710595 |
| 57 | regulation of natural killer cell activation (GO:0032814) | 3.67081454 |
| 58 | positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357 | 3.62652651 |
| 59 | N-glycan processing (GO:0006491) | 3.59646627 |
| 60 | positive regulation of alpha-beta T cell differentiation (GO:0046638) | 3.59575983 |
| 61 | positive regulation of natural killer cell activation (GO:0032816) | 3.53474062 |
| 62 | AMP metabolic process (GO:0046033) | 3.48807792 |
| 63 | positive regulation of interleukin-12 production (GO:0032735) | 3.44180025 |
| 64 | negative regulation of T cell mediated immunity (GO:0002710) | 3.43355653 |
| 65 | negative regulation of mast cell activation (GO:0033004) | 3.38615833 |
| 66 | base-excision repair, AP site formation (GO:0006285) | 3.37822496 |
| 67 | cellular anion homeostasis (GO:0030002) | 3.37195480 |
| 68 | positive regulation of myeloid leukocyte differentiation (GO:0002763) | 3.35719426 |
| 69 | trivalent inorganic anion homeostasis (GO:0072506) | 3.33881936 |
| 70 | phosphate ion homeostasis (GO:0055062) | 3.33881936 |
| 71 | regulation of activated T cell proliferation (GO:0046006) | 3.33740250 |
| 72 | lymph node development (GO:0048535) | 3.32394564 |
| 73 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.32254727 |
| 74 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.30588530 |
| 75 | lysosome localization (GO:0032418) | 3.29496016 |
| 76 | positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517) | 3.18011563 |
| 77 | regulation of alpha-beta T cell differentiation (GO:0046637) | 3.17880272 |
| 78 | positive regulation of T cell cytokine production (GO:0002726) | 3.16033956 |
| 79 | natural killer cell activation (GO:0030101) | 3.15173675 |
| 80 | negative regulation of DNA-templated transcription, elongation (GO:0032785) | 3.14040379 |
| 81 | regulation of interleukin-12 production (GO:0032655) | 3.13236089 |
| 82 | regulation of interleukin-10 production (GO:0032653) | 3.07169823 |
| 83 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.07161463 |
| 84 | positive regulation of alpha-beta T cell activation (GO:0046635) | 3.03906927 |
| 85 | negative regulation of glycogen biosynthetic process (GO:0045719) | 3.02918927 |
| 86 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.96725559 |
| 87 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.95266189 |
| 88 | positive regulation of macrophage derived foam cell differentiation (GO:0010744) | 2.93678400 |
| 89 | positive regulation of interferon-gamma production (GO:0032729) | 2.93394475 |
| 90 | positive regulation of prostaglandin secretion (GO:0032308) | 2.93269544 |
| 91 | response to muramyl dipeptide (GO:0032495) | 2.91663617 |
| 92 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 2.91337864 |
| 93 | regulation of vitamin D biosynthetic process (GO:0060556) | 2.88466227 |
| 94 | cellular response to interleukin-6 (GO:0071354) | 2.87494559 |
| 95 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.86274986 |
| 96 | tolerance induction (GO:0002507) | 2.85632351 |
| 97 | regulation of osteoclast differentiation (GO:0045670) | 2.83301292 |
| 98 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.82672061 |
| 99 | negative T cell selection (GO:0043383) | 2.81288823 |
| 100 | regulation of memory T cell differentiation (GO:0043380) | 11.2322068 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 6.04158362 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.43382006 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.31688364 |
| 4 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.26001781 |
| 5 | GATA1_22025678_ChIP-Seq_K562_Human | 3.33520008 |
| 6 | MYB_26560356_Chip-Seq_TH2_Human | 3.20905538 |
| 7 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.85630968 |
| 8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.82762312 |
| 9 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.82069267 |
| 10 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.70898725 |
| 11 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.67828597 |
| 12 | GATA3_26560356_Chip-Seq_TH2_Human | 2.55259253 |
| 13 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.53486686 |
| 14 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 2.31774466 |
| 15 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.30704383 |
| 16 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.24663312 |
| 17 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.24204020 |
| 18 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.06046189 |
| 19 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.05720034 |
| 20 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.04989365 |
| 21 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.04832281 |
| 22 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.93103383 |
| 23 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.91325578 |
| 24 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.85044275 |
| 25 | MYB_26560356_Chip-Seq_TH1_Human | 1.82672634 |
| 26 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.75489488 |
| 27 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.73302307 |
| 28 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.70213623 |
| 29 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.69606003 |
| 30 | MAF_26560356_Chip-Seq_TH1_Human | 1.69187204 |
| 31 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.67711747 |
| 32 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.63589634 |
| 33 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.50232280 |
| 34 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.49755868 |
| 35 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.42973281 |
| 36 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.42344938 |
| 37 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.38694412 |
| 38 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.38357855 |
| 39 | MAF_26560356_Chip-Seq_TH2_Human | 1.37409110 |
| 40 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.35556298 |
| 41 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.31445485 |
| 42 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.31126082 |
| 43 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.27751364 |
| 44 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.26217887 |
| 45 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.23665131 |
| 46 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.17644385 |
| 47 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.14910407 |
| 48 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.13489340 |
| 49 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.12570197 |
| 50 | MYC_22102868_ChIP-Seq_BL_Human | 1.12392900 |
| 51 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.11172899 |
| 52 | P300_27268052_Chip-Seq_Bcells_Human | 1.11071015 |
| 53 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.10329377 |
| 54 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.09211514 |
| 55 | P68_20966046_ChIP-Seq_HELA_Human | 1.08756505 |
| 56 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.08534660 |
| 57 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.06153757 |
| 58 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.05963545 |
| 59 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.05773865 |
| 60 | SA1_27219007_Chip-Seq_Bcells_Human | 1.04055187 |
| 61 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.03342362 |
| 62 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02627317 |
| 63 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.00417792 |
| 64 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.99814303 |
| 65 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.98038458 |
| 66 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.97936109 |
| 67 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.97936109 |
| 68 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.95277075 |
| 69 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.95196732 |
| 70 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.94560223 |
| 71 | GATA3_26560356_Chip-Seq_TH1_Human | 0.93243470 |
| 72 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.93228055 |
| 73 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.93157844 |
| 74 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.92734236 |
| 75 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.92705798 |
| 76 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.92453643 |
| 77 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.92252484 |
| 78 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.92006025 |
| 79 | AR_20517297_ChIP-Seq_VCAP_Human | 0.91212496 |
| 80 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.90390208 |
| 81 | * GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.90306574 |
| 82 | * FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.89730870 |
| 83 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.89644010 |
| 84 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.89514425 |
| 85 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 0.88829953 |
| 86 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.88716906 |
| 87 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.88494229 |
| 88 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.87838788 |
| 89 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.85490434 |
| 90 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85046441 |
| 91 | * HOXB7_26014856_ChIP-Seq_BT474_Human | 0.84195618 |
| 92 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.83594589 |
| 93 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.83434676 |
| 94 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.83013384 |
| 95 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.82040895 |
| 96 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.81769697 |
| 97 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.81757164 |
| 98 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.81753204 |
| 99 | * SPI1_20517297_ChIP-Seq_HL60_Human | 0.81717317 |
| 100 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.80717339 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003195_calcinosis | 5.13033289 |
| 2 | MP0005671_abnormal_response_to | 4.92691738 |
| 3 | MP0003878_abnormal_ear_physiology | 3.50784997 |
| 4 | MP0005377_hearing/vestibular/ear_phenot | 3.50784997 |
| 5 | MP0003763_abnormal_thymus_physiology | 3.40091156 |
| 6 | MP0005075_abnormal_melanosome_morpholog | 3.27448783 |
| 7 | MP0005000_abnormal_immune_tolerance | 3.02217084 |
| 8 | MP0003879_abnormal_hair_cell | 2.95935985 |
| 9 | MP0002877_abnormal_melanocyte_morpholog | 2.72920088 |
| 10 | MP0003303_peritoneal_inflammation | 2.71045045 |
| 11 | MP0001835_abnormal_antigen_presentation | 2.65287302 |
| 12 | MP0003724_increased_susceptibility_to | 2.54937334 |
| 13 | MP0009785_altered_susceptibility_to | 2.33082873 |
| 14 | MP0003866_abnormal_defecation | 2.28873639 |
| 15 | MP0002723_abnormal_immune_serum | 2.27280398 |
| 16 | MP0004885_abnormal_endolymph | 2.24777200 |
| 17 | MP0001800_abnormal_humoral_immune | 2.16622936 |
| 18 | MP0008877_abnormal_DNA_methylation | 2.14813066 |
| 19 | MP0001188_hyperpigmentation | 2.12861980 |
| 20 | MP0003436_decreased_susceptibility_to | 2.10741385 |
| 21 | MP0001819_abnormal_immune_cell | 2.03944703 |
| 22 | MP0003638_abnormal_response/metabolism_ | 2.00756972 |
| 23 | MP0002420_abnormal_adaptive_immunity | 1.99207401 |
| 24 | MP0002933_joint_inflammation | 1.93514077 |
| 25 | MP0002148_abnormal_hypersensitivity_rea | 1.86824969 |
| 26 | MP0002452_abnormal_antigen_presenting | 1.82848139 |
| 27 | MP0004947_skin_inflammation | 1.81843955 |
| 28 | MP0000685_abnormal_immune_system | 1.79038006 |
| 29 | MP0002419_abnormal_innate_immunity | 1.72430562 |
| 30 | MP0001533_abnormal_skeleton_physiology | 1.72289891 |
| 31 | MP0000465_gastrointestinal_hemorrhage | 1.71663201 |
| 32 | MP0005025_abnormal_response_to | 1.69876453 |
| 33 | MP0000716_abnormal_immune_system | 1.63101396 |
| 34 | MP0000703_abnormal_thymus_morphology | 1.58494019 |
| 35 | MP0002405_respiratory_system_inflammati | 1.58450332 |
| 36 | MP0001765_abnormal_ion_homeostasis | 1.57905281 |
| 37 | MP0002398_abnormal_bone_marrow | 1.55313967 |
| 38 | MP0001790_abnormal_immune_system | 1.53105689 |
| 39 | MP0005387_immune_system_phenotype | 1.53105689 |
| 40 | MP0002998_abnormal_bone_remodeling | 1.52330878 |
| 41 | MP0002138_abnormal_hepatobiliary_system | 1.50290852 |
| 42 | MP0002722_abnormal_immune_system | 1.46368475 |
| 43 | MP0000371_diluted_coat_color | 1.42003548 |
| 44 | MP0010155_abnormal_intestine_physiology | 1.39563141 |
| 45 | MP0001501_abnormal_sleep_pattern | 1.37994214 |
| 46 | MP0000689_abnormal_spleen_morphology | 1.37317309 |
| 47 | MP0002102_abnormal_ear_morphology | 1.34046106 |
| 48 | MP0001845_abnormal_inflammatory_respons | 1.33716912 |
| 49 | MP0002736_abnormal_nociception_after | 1.31973131 |
| 50 | MP0010368_abnormal_lymphatic_system | 1.30778991 |
| 51 | MP0008872_abnormal_physiological_respon | 1.26123130 |
| 52 | MP0001502_abnormal_circadian_rhythm | 1.25260852 |
| 53 | MP0004147_increased_porphyrin_level | 1.25230708 |
| 54 | MP0004742_abnormal_vestibular_system | 1.25057582 |
| 55 | MP0002429_abnormal_blood_cell | 1.25054859 |
| 56 | MP0001851_eye_inflammation | 1.23907135 |
| 57 | MP0009278_abnormal_bone_marrow | 1.14389724 |
| 58 | MP0009333_abnormal_splenocyte_physiolog | 1.11697782 |
| 59 | MP0003300_gastrointestinal_ulcer | 1.09397518 |
| 60 | MP0001968_abnormal_touch/_nociception | 1.07308890 |
| 61 | MP0005083_abnormal_biliary_tract | 1.04542649 |
| 62 | MP0005084_abnormal_gallbladder_morpholo | 1.04465559 |
| 63 | MP0003191_abnormal_cellular_cholesterol | 0.99851303 |
| 64 | MP0009764_decreased_sensitivity_to | 0.94063242 |
| 65 | MP0008961_abnormal_basal_metabolism | 0.93228923 |
| 66 | MP0002876_abnormal_thyroid_physiology | 0.89585829 |
| 67 | MP0003828_pulmonary_edema | 0.86536823 |
| 68 | MP0005464_abnormal_platelet_physiology | 0.85816441 |
| 69 | MP0005390_skeleton_phenotype | 0.82863250 |
| 70 | MP0003795_abnormal_bone_structure | 0.81405029 |
| 71 | MP0005174_abnormal_tail_pigmentation | 0.79159234 |
| 72 | MP0005167_abnormal_blood-brain_barrier | 0.77979091 |
| 73 | MP0009763_increased_sensitivity_to | 0.77606777 |
| 74 | MP0006072_abnormal_retinal_apoptosis | 0.76633734 |
| 75 | MP0008995_early_reproductive_senescence | 0.75229023 |
| 76 | MP0003252_abnormal_bile_duct | 0.72909612 |
| 77 | MP0008469_abnormal_protein_level | 0.72608281 |
| 78 | MP0004142_abnormal_muscle_tone | 0.72163091 |
| 79 | MP0004043_abnormal_pH_regulation | 0.72107985 |
| 80 | MP0003786_premature_aging | 0.69332637 |
| 81 | MP0005076_abnormal_cell_differentiation | 0.68803272 |
| 82 | MP0003448_altered_tumor_morphology | 0.68492343 |
| 83 | MP0008873_increased_physiological_sensi | 0.68051208 |
| 84 | MP0003011_delayed_dark_adaptation | 0.67787284 |
| 85 | MP0008875_abnormal_xenobiotic_pharmacok | 0.67618329 |
| 86 | MP0001485_abnormal_pinna_reflex | 0.65885493 |
| 87 | MP0000367_abnormal_coat/_hair | 0.65586217 |
| 88 | MP0002075_abnormal_coat/hair_pigmentati | 0.64432128 |
| 89 | MP0001764_abnormal_homeostasis | 0.64043086 |
| 90 | MP0003183_abnormal_peptide_metabolism | 0.62730830 |
| 91 | MP0002272_abnormal_nervous_system | 0.61060648 |
| 92 | MP0009765_abnormal_xenobiotic_induced | 0.60427040 |
| 93 | MP0001348_abnormal_lacrimal_gland | 0.60295397 |
| 94 | MP0005165_increased_susceptibility_to | 0.60146758 |
| 95 | MP0001919_abnormal_reproductive_system | 0.59727110 |
| 96 | MP0002166_altered_tumor_susceptibility | 0.58909181 |
| 97 | MP0001873_stomach_inflammation | 0.58092239 |
| 98 | MP0001963_abnormal_hearing_physiology | 0.57983875 |
| 99 | MP0000609_abnormal_liver_physiology | 0.56970923 |
| 100 | MP0008775_abnormal_heart_ventricle | 0.55786861 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Optic neuritis (HP:0100653) | 9.30689856 |
| 2 | Retrobulbar optic neuritis (HP:0100654) | 9.30689856 |
| 3 | Orchitis (HP:0100796) | 8.17222495 |
| 4 | Myositis (HP:0100614) | 7.61384823 |
| 5 | Keratoconjunctivitis sicca (HP:0001097) | 6.30560398 |
| 6 | Keratoconjunctivitis (HP:0001096) | 6.05917354 |
| 7 | Brittle hair (HP:0002299) | 5.36635411 |
| 8 | Hypotrichosis (HP:0001006) | 4.58844952 |
| 9 | T lymphocytopenia (HP:0005403) | 4.58496257 |
| 10 | Abnormality of eosinophils (HP:0001879) | 4.53446090 |
| 11 | Renal cortical cysts (HP:0000803) | 4.43543912 |
| 12 | Severe combined immunodeficiency (HP:0004430) | 4.16147094 |
| 13 | Slow-growing hair (HP:0002217) | 4.12393506 |
| 14 | Abnormality of hair growth rate (HP:0011363) | 4.12393506 |
| 15 | Abnormality of T cell number (HP:0011839) | 4.01276455 |
| 16 | IgG deficiency (HP:0004315) | 3.80991211 |
| 17 | Arterial thrombosis (HP:0004420) | 3.73261634 |
| 18 | Hypophosphatemic rickets (HP:0004912) | 3.73156946 |
| 19 | Pulmonary infiltrates (HP:0002113) | 3.72253411 |
| 20 | Persistence of primary teeth (HP:0006335) | 3.62964347 |
| 21 | Encephalitis (HP:0002383) | 3.55223028 |
| 22 | Granulocytopenia (HP:0001913) | 3.47202897 |
| 23 | Anorexia (HP:0002039) | 3.46305506 |
| 24 | Eosinophilia (HP:0001880) | 3.39121048 |
| 25 | Gangrene (HP:0100758) | 3.26267253 |
| 26 | Combined immunodeficiency (HP:0005387) | 3.21353644 |
| 27 | Vertigo (HP:0002321) | 3.16359029 |
| 28 | Vasculitis (HP:0002633) | 3.08327064 |
| 29 | Hemoptysis (HP:0002105) | 3.01735833 |
| 30 | Abnormality of T cells (HP:0002843) | 2.99683897 |
| 31 | Polyneuropathy (HP:0001271) | 2.96611541 |
| 32 | Gastrointestinal stroma tumor (HP:0100723) | 2.88381490 |
| 33 | Abnormality of the renal cortex (HP:0011035) | 2.87490261 |
| 34 | Keratitis (HP:0000491) | 2.86691343 |
| 35 | Flat capital femoral epiphysis (HP:0003370) | 2.83888535 |
| 36 | Leukocytosis (HP:0001974) | 2.81953441 |
| 37 | Pulmonary embolism (HP:0002204) | 2.78090845 |
| 38 | Conical tooth (HP:0000698) | 2.72944088 |
| 39 | Neoplasm of head and neck (HP:0012288) | 2.71108725 |
| 40 | Esophageal neoplasm (HP:0100751) | 2.71108725 |
| 41 | Stomach cancer (HP:0012126) | 2.66175886 |
| 42 | Thyroiditis (HP:0100646) | 2.56513067 |
| 43 | Glomerulopathy (HP:0100820) | 2.55934601 |
| 44 | Pancreatitis (HP:0001733) | 2.51427243 |
| 45 | Delayed CNS myelination (HP:0002188) | 2.47973802 |
| 46 | Anhidrosis (HP:0000970) | 2.47516201 |
| 47 | Nephronophthisis (HP:0000090) | 2.43211873 |
| 48 | Thrombophlebitis (HP:0004418) | 2.38338029 |
| 49 | Abnormality of dental color (HP:0011073) | 2.37851037 |
| 50 | Adactyly (HP:0009776) | 2.33686624 |
| 51 | Acne (HP:0001061) | 2.31271045 |
| 52 | Pustule (HP:0200039) | 2.28104678 |
| 53 | Hypophosphatemia (HP:0002148) | 2.27646652 |
| 54 | Premature loss of primary teeth (HP:0006323) | 2.26670703 |
| 55 | Joint swelling (HP:0001386) | 2.21026264 |
| 56 | Tongue fasciculations (HP:0001308) | 2.20545357 |
| 57 | Abnormality of the pleura (HP:0002103) | 2.18896082 |
| 58 | Type II lissencephaly (HP:0007260) | 2.18426586 |
| 59 | Eczematoid dermatitis (HP:0000976) | 2.14924094 |
| 60 | Short tibia (HP:0005736) | 2.14479232 |
| 61 | Abnormality of the proximal phalanges of the hand (HP:0009834) | 2.11601975 |
| 62 | Muscle fibrillation (HP:0010546) | 2.10507481 |
| 63 | Papilledema (HP:0001085) | 2.07801893 |
| 64 | Arthralgia (HP:0002829) | 2.05667005 |
| 65 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.05489962 |
| 66 | Abnormality of the pericardium (HP:0001697) | 2.03567863 |
| 67 | Vascular calcification (HP:0004934) | 2.02599212 |
| 68 | Porencephaly (HP:0002132) | 1.96455687 |
| 69 | Abolished electroretinogram (ERG) (HP:0000550) | 1.94951351 |
| 70 | Increased IgE level (HP:0003212) | 1.94649508 |
| 71 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.93283987 |
| 72 | Abnormality of the endocardium (HP:0004306) | 1.90836699 |
| 73 | Pulmonary fibrosis (HP:0002206) | 1.90523699 |
| 74 | Nail dystrophy (HP:0008404) | 1.90522024 |
| 75 | Meningitis (HP:0001287) | 1.89209767 |
| 76 | Clumsiness (HP:0002312) | 1.86025434 |
| 77 | Flattened epiphyses (HP:0003071) | 1.84001938 |
| 78 | Stomatitis (HP:0010280) | 1.83179379 |
| 79 | Hypoplasia of the thymus (HP:0000778) | 1.82700464 |
| 80 | Hypoplasia of the pons (HP:0012110) | 1.82419519 |
| 81 | Tinnitus (HP:0000360) | 1.81058255 |
| 82 | Abnormality of T cell physiology (HP:0011840) | 1.79746711 |
| 83 | Fine hair (HP:0002213) | 1.79605661 |
| 84 | Congenital stationary night blindness (HP:0007642) | 1.79316684 |
| 85 | Abnormality of the pons (HP:0007361) | 1.78139325 |
| 86 | Abnormality of the renal medulla (HP:0100957) | 1.75859595 |
| 87 | Prostate neoplasm (HP:0100787) | 1.75703824 |
| 88 | Abnormality of intracranial pressure (HP:0012640) | 1.75508037 |
| 89 | Increased intracranial pressure (HP:0002516) | 1.75508037 |
| 90 | Pancreatic cysts (HP:0001737) | 1.74728412 |
| 91 | Cardiovascular calcification (HP:0011915) | 1.74085308 |
| 92 | Alveolar cell carcinoma (HP:0006519) | 1.73964888 |
| 93 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.72527780 |
| 94 | Spinal cord lesions (HP:0100561) | 1.69685746 |
| 95 | Syringomyelia (HP:0003396) | 1.69685746 |
| 96 | Facial diplegia (HP:0001349) | 1.64529695 |
| 97 | Increased density of long bones (HP:0006392) | 1.64435915 |
| 98 | Mediastinal lymphadenopathy (HP:0100721) | 1.63606766 |
| 99 | Brushfield spots (HP:0001088) | 1.62666260 |
| 100 | Recurrent bronchitis (HP:0002837) | 1.62655178 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA3 | 4.90985098 |
| 2 | MAP4K2 | 4.77646908 |
| 3 | TXK | 4.45517018 |
| 4 | MAP3K14 | 4.14880584 |
| 5 | GRK6 | 3.72522438 |
| 6 | MUSK | 3.04281944 |
| 7 | TAOK3 | 2.73838324 |
| 8 | JAK1 | 2.53484178 |
| 9 | EPHB1 | 2.48747077 |
| 10 | SIK3 | 2.42159095 |
| 11 | IKBKE | 2.30225710 |
| 12 | IKBKB | 2.14204196 |
| 13 | KIT | 2.08880921 |
| 14 | TBK1 | 2.07541466 |
| 15 | ZAK | 1.94557989 |
| 16 | MAP2K2 | 1.83273136 |
| 17 | IRAK1 | 1.72668699 |
| 18 | FES | 1.72014020 |
| 19 | ARAF | 1.70589458 |
| 20 | TLK1 | 1.68956913 |
| 21 | BRD4 | 1.62830173 |
| 22 | FGFR4 | 1.62661990 |
| 23 | BCKDK | 1.57442576 |
| 24 | CHUK | 1.55712531 |
| 25 | MATK | 1.49508023 |
| 26 | TESK2 | 1.49324358 |
| 27 | KDR | 1.39094210 |
| 28 | MAP4K1 | 1.25168103 |
| 29 | GRK1 | 1.23762647 |
| 30 | PIM2 | 1.22155509 |
| 31 | BMPR2 | 1.20292408 |
| 32 | IRAK4 | 1.20102044 |
| 33 | CLK1 | 1.13955963 |
| 34 | LCK | 1.08965907 |
| 35 | PRKCQ | 1.07290690 |
| 36 | FER | 1.05402457 |
| 37 | RIPK4 | 1.00560692 |
| 38 | EIF2AK2 | 0.96346367 |
| 39 | CDK19 | 0.95848564 |
| 40 | ADRBK2 | 0.90104814 |
| 41 | NLK | 0.87188072 |
| 42 | ERN1 | 0.86277101 |
| 43 | FGFR3 | 0.84801184 |
| 44 | ZAP70 | 0.82714523 |
| 45 | PIM1 | 0.82432970 |
| 46 | CSK | 0.79690971 |
| 47 | TIE1 | 0.79334724 |
| 48 | MARK3 | 0.79334487 |
| 49 | RPS6KA5 | 0.77823357 |
| 50 | OXSR1 | 0.77458085 |
| 51 | HCK | 0.76445821 |
| 52 | LYN | 0.73563974 |
| 53 | IGF1R | 0.72484534 |
| 54 | PRKCH | 0.71888067 |
| 55 | NEK6 | 0.71615641 |
| 56 | MST4 | 0.71492575 |
| 57 | SYK | 0.64102495 |
| 58 | SIK2 | 0.63271300 |
| 59 | MAPK11 | 0.60770272 |
| 60 | INSR | 0.59549737 |
| 61 | MAPKAPK2 | 0.59265704 |
| 62 | CDK3 | 0.57992961 |
| 63 | MAPK15 | 0.57132813 |
| 64 | PHKG1 | 0.51405755 |
| 65 | PHKG2 | 0.51405755 |
| 66 | BTK | 0.48253222 |
| 67 | CSNK1A1L | 0.45844506 |
| 68 | NEK1 | 0.44794364 |
| 69 | EGFR | 0.43358381 |
| 70 | RAF1 | 0.42871339 |
| 71 | CSNK1G3 | 0.41649170 |
| 72 | PRKCI | 0.41046359 |
| 73 | PDK1 | 0.40379288 |
| 74 | JAK3 | 0.39921915 |
| 75 | MAPK7 | 0.39473713 |
| 76 | PIK3CA | 0.38314568 |
| 77 | MAP3K4 | 0.38130203 |
| 78 | STK4 | 0.37983101 |
| 79 | CDK4 | 0.37371658 |
| 80 | PIK3CG | 0.36738120 |
| 81 | CSNK1G2 | 0.35543078 |
| 82 | JAK2 | 0.35152820 |
| 83 | HIPK2 | 0.34421845 |
| 84 | STK38 | 0.30517214 |
| 85 | FYN | 0.29611497 |
| 86 | VRK1 | 0.29234332 |
| 87 | CSF1R | 0.28856190 |
| 88 | MET | 0.26342175 |
| 89 | RPS6KA1 | 0.26230233 |
| 90 | LIMK1 | 0.25853299 |
| 91 | NUAK1 | 0.24223130 |
| 92 | TYK2 | 0.22139040 |
| 93 | SRPK1 | 0.21261873 |
| 94 | RPS6KA4 | 0.20805864 |
| 95 | RPS6KA2 | 0.20487936 |
| 96 | ABL1 | 0.20176910 |
| 97 | MAPK3 | 0.19940609 |
| 98 | PINK1 | 0.19108140 |
| 99 | RPS6KA6 | 0.18595298 |
| 100 | CDK6 | 0.17372647 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 5.04062443 |
| 2 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.52786483 |
| 3 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.18914246 |
| 4 | * Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.09068800 |
| 5 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 2.84921728 |
| 6 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 2.72488622 |
| 7 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 2.66171542 |
| 8 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.54055283 |
| 9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.49914821 |
| 10 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 2.32414706 |
| 11 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.25089091 |
| 12 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.22897269 |
| 13 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.21455269 |
| 14 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 2.08970477 |
| 15 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 2.08838126 |
| 16 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.79790040 |
| 17 | Measles_Homo sapiens_hsa05162 | 1.72531605 |
| 18 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.69563362 |
| 19 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.63329101 |
| 20 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.61931795 |
| 21 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.61517839 |
| 22 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.59186090 |
| 23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.56025112 |
| 24 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.55774748 |
| 25 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.52681260 |
| 26 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.51303695 |
| 27 | Shigellosis_Homo sapiens_hsa05131 | 1.45872225 |
| 28 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.34634511 |
| 29 | Leishmaniasis_Homo sapiens_hsa05140 | 1.32940294 |
| 30 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.31300201 |
| 31 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.25212426 |
| 32 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.25004333 |
| 33 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.23946542 |
| 34 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.20493505 |
| 35 | Phototransduction_Homo sapiens_hsa04744 | 1.18758829 |
| 36 | Legionellosis_Homo sapiens_hsa05134 | 1.10816047 |
| 37 | Malaria_Homo sapiens_hsa05144 | 1.09089131 |
| 38 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.08254290 |
| 39 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.08163049 |
| 40 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.99815948 |
| 41 | Peroxisome_Homo sapiens_hsa04146 | 0.95230713 |
| 42 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.93515458 |
| 43 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.90266461 |
| 44 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.90049216 |
| 45 | Hepatitis C_Homo sapiens_hsa05160 | 0.77527859 |
| 46 | Hepatitis B_Homo sapiens_hsa05161 | 0.77192093 |
| 47 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.76059495 |
| 48 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.75942722 |
| 49 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.75831703 |
| 50 | ABC transporters_Homo sapiens_hsa02010 | 0.73642991 |
| 51 | Apoptosis_Homo sapiens_hsa04210 | 0.73503203 |
| 52 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.73031193 |
| 53 | Pertussis_Homo sapiens_hsa05133 | 0.72750278 |
| 54 | Asthma_Homo sapiens_hsa05310 | 0.70087092 |
| 55 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.69522122 |
| 56 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.65670060 |
| 57 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.65588880 |
| 58 | Circadian rhythm_Homo sapiens_hsa04710 | 0.62335846 |
| 59 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.61802374 |
| 60 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.61779205 |
| 61 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.61217981 |
| 62 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.60904874 |
| 63 | Influenza A_Homo sapiens_hsa05164 | 0.60383213 |
| 64 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.59844528 |
| 65 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.59153076 |
| 66 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.59094077 |
| 67 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.59066252 |
| 68 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.55539178 |
| 69 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.54869234 |
| 70 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.54018130 |
| 71 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.53108874 |
| 72 | Lysosome_Homo sapiens_hsa04142 | 0.48688762 |
| 73 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.47968665 |
| 74 | Allograft rejection_Homo sapiens_hsa05330 | 0.43542923 |
| 75 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.41431047 |
| 76 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.41069423 |
| 77 | Tuberculosis_Homo sapiens_hsa05152 | 0.38882804 |
| 78 | Purine metabolism_Homo sapiens_hsa00230 | 0.38699899 |
| 79 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.38306431 |
| 80 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36699714 |
| 81 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.33650694 |
| 82 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.33398561 |
| 83 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.32352009 |
| 84 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.30130494 |
| 85 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.29610814 |
| 86 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.28167884 |
| 87 | Taste transduction_Homo sapiens_hsa04742 | 0.27835519 |
| 88 | Base excision repair_Homo sapiens_hsa03410 | 0.25336993 |
| 89 | HTLV-I infection_Homo sapiens_hsa05166 | 0.24790700 |
| 90 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.24774416 |
| 91 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.24101893 |
| 92 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.22575690 |
| 93 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.21514860 |
| 94 | RNA degradation_Homo sapiens_hsa03018 | 0.21513646 |
| 95 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.20424773 |
| 96 | Nicotine addiction_Homo sapiens_hsa05033 | 0.19779839 |
| 97 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.19552959 |
| 98 | Olfactory transduction_Homo sapiens_hsa04740 | 0.19499013 |
| 99 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.18313444 |
| 100 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.18083792 |

