NCSTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.65106642
2Golgi transport vesicle coating (GO:0048200)7.65106642
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.73931362
4protein retention in ER lumen (GO:0006621)4.39505513
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19663323
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19663323
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.18855646
8epithelial cell fate commitment (GO:0072148)4.02928274
9apoptotic cell clearance (GO:0043277)3.72273950
10pinocytosis (GO:0006907)3.67087312
11antigen processing and presentation of endogenous antigen (GO:0019883)3.66788330
12activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.60282800
13positive regulation of nuclease activity (GO:0032075)3.44642634
14barbed-end actin filament capping (GO:0051016)3.44341132
15exocrine pancreas development (GO:0031017)3.37147222
16vesicle coating (GO:0006901)3.33814064
17sequestering of metal ion (GO:0051238)3.33725550
18axon extension involved in axon guidance (GO:0048846)3.30333890
19neuron projection extension involved in neuron projection guidance (GO:1902284)3.30333890
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.23989769
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.23989769
22modulation by symbiont of host immune response (GO:0052553)3.23989769
23positive regulation by symbiont of host defense response (GO:0052509)3.23989769
24modulation by symbiont of host defense response (GO:0052031)3.23989769
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.23989769
26COPII vesicle coating (GO:0048208)3.19660468
27endoplasmic reticulum unfolded protein response (GO:0030968)3.16610966
28glucose 6-phosphate metabolic process (GO:0051156)3.16021118
29positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.14438772
30protein localization to endosome (GO:0036010)3.14029443
31regulation of nuclease activity (GO:0032069)3.11036744
32stress fiber assembly (GO:0043149)3.05250307
33cellular response to unfolded protein (GO:0034620)3.04546274
34cellular copper ion homeostasis (GO:0006878)3.04044680
35negative regulation of fatty acid transport (GO:2000192)3.03777236
36epithelial cell differentiation involved in prostate gland development (GO:0060742)3.02398506
37chondrocyte proliferation (GO:0035988)2.97680514
38ER-nucleus signaling pathway (GO:0006984)2.97511949
39response to laminar fluid shear stress (GO:0034616)2.97246685
40glycosphingolipid catabolic process (GO:0046479)2.94164406
41alpha-linolenic acid metabolic process (GO:0036109)2.92048424
42cellular response to topologically incorrect protein (GO:0035967)2.89183469
43positive regulation of extracellular matrix organization (GO:1903055)2.88933114
44peptide catabolic process (GO:0043171)2.88601028
45regulation of apoptotic cell clearance (GO:2000425)2.85374598
46* membrane protein ectodomain proteolysis (GO:0006509)2.82224783
47Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80144245
48protein carboxylation (GO:0018214)2.79071194
49peptidyl-glutamic acid carboxylation (GO:0017187)2.79071194
50lung epithelium development (GO:0060428)2.76824977
51positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.76754307
52signal peptide processing (GO:0006465)2.76168770
53peptidyl-proline hydroxylation (GO:0019511)2.75535549
54antigen processing and presentation via MHC class Ib (GO:0002475)2.73059416
55keratan sulfate catabolic process (GO:0042340)2.71910340
56mannose metabolic process (GO:0006013)2.69665196
57adhesion of symbiont to host (GO:0044406)2.69216445
58L-alpha-amino acid transmembrane transport (GO:1902475)2.68773718
59negative regulation of fibrinolysis (GO:0051918)2.67462955
60protein maturation by protein folding (GO:0022417)2.66279613
61glycolipid catabolic process (GO:0019377)2.65638963
62protein hydroxylation (GO:0018126)2.65454366
63regulation of interferon-beta biosynthetic process (GO:0045357)2.65176210
64cell adhesion mediated by integrin (GO:0033627)2.65044030
65venous blood vessel morphogenesis (GO:0048845)2.64754137
66hemidesmosome assembly (GO:0031581)2.60247238
67fibril organization (GO:0097435)2.59846473
68negative regulation of protein activation cascade (GO:2000258)2.59414979
69negative regulation of complement activation (GO:0045916)2.57956433
70NADPH regeneration (GO:0006740)2.55499479
71skin morphogenesis (GO:0043589)2.54945204
72response to endoplasmic reticulum stress (GO:0034976)2.54806923
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.53773941
74basement membrane organization (GO:0071711)2.53007019
75chaperone mediated protein folding requiring cofactor (GO:0051085)2.52793564
76adhesion of symbiont to host cell (GO:0044650)2.52731992
77virion attachment to host cell (GO:0019062)2.52731992
78negative regulation of protein localization to plasma membrane (GO:1903077)2.51867909
79regulation of cholesterol homeostasis (GO:2000188)2.51734254
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.50681231
81endodermal cell differentiation (GO:0035987)2.50020244
82collagen metabolic process (GO:0032963)2.48995349
83extracellular fibril organization (GO:0043206)2.48536660
84endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.47369982
85macrophage activation involved in immune response (GO:0002281)2.47166773
86negative regulation of smooth muscle cell migration (GO:0014912)2.46322750
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46288901
88positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46062155
89platelet degranulation (GO:0002576)2.45191685
90regulation of complement activation (GO:0030449)2.44825976
91positive regulation of receptor recycling (GO:0001921)2.44677367
92regulation of extracellular matrix disassembly (GO:0010715)2.44465993
93regulation of protein activation cascade (GO:2000257)2.43519060
944-hydroxyproline metabolic process (GO:0019471)2.43114831
95response to thyroid hormone (GO:0097066)2.42334595
96response to muramyl dipeptide (GO:0032495)2.41740883
97collagen fibril organization (GO:0030199)2.41568026
98response to host (GO:0075136)2.39866454
99response to host defenses (GO:0052200)2.39866454
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.39866454
101cellular response to vitamin D (GO:0071305)2.39860567
102* extracellular matrix disassembly (GO:0022617)2.39607780
103oligosaccharide catabolic process (GO:0009313)2.39345498
104collagen catabolic process (GO:0030574)2.37862778
105negative regulation of erythrocyte differentiation (GO:0045647)2.36565325
106cellular response to vitamin (GO:0071295)2.36409418
107semaphorin-plexin signaling pathway (GO:0071526)2.36314461
108negative regulation of humoral immune response (GO:0002921)2.35565708
109multicellular organismal macromolecule metabolic process (GO:0044259)2.35048623
110glandular epithelial cell development (GO:0002068)2.34484653
111L-serine transport (GO:0015825)2.34104015
112peptidyl-asparagine modification (GO:0018196)2.33710004
113type B pancreatic cell proliferation (GO:0044342)2.33379704
114protein N-linked glycosylation via asparagine (GO:0018279)2.32501526
115endocardial cushion morphogenesis (GO:0003203)2.32094963
116cell-substrate junction assembly (GO:0007044)2.31923618
117wound healing, spreading of epidermal cells (GO:0035313)2.30581773
118glucose catabolic process (GO:0006007)2.29972009
119type B pancreatic cell development (GO:0003323)2.29774702
120atrioventricular valve morphogenesis (GO:0003181)2.29640012
121ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.29577204
122cellular response to nutrient (GO:0031670)2.29359409
123embryo implantation (GO:0007566)2.29175986
124positive regulation of phagocytosis (GO:0050766)2.29133248
125hyaluronan catabolic process (GO:0030214)2.28808205
126muscle cell migration (GO:0014812)2.28341250
127plasma lipoprotein particle assembly (GO:0034377)2.27704798
128amino sugar catabolic process (GO:0046348)2.27590819
129very-low-density lipoprotein particle assembly (GO:0034379)2.27244592
130Notch signaling involved in heart development (GO:0061314)2.27012842
131growth hormone receptor signaling pathway (GO:0060396)2.25893576
132macroautophagy (GO:0016236)2.25590835
133substrate-dependent cell migration (GO:0006929)2.25519614
134germ cell migration (GO:0008354)2.24996524
135detection of molecule of bacterial origin (GO:0032490)2.24918895
136multicellular organismal catabolic process (GO:0044243)2.24759154
137decidualization (GO:0046697)2.24327399
138serine transport (GO:0032329)2.24000529
139positive regulation of histone deacetylation (GO:0031065)2.23728354
140positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.23463654
141positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.22948576
142wound healing, spreading of cells (GO:0044319)2.22888871
143protein-lipid complex assembly (GO:0065005)2.22263231
144actin nucleation (GO:0045010)2.22048226
145regulation of cholesterol storage (GO:0010885)2.21297206
146response to unfolded protein (GO:0006986)2.20884809
147positive regulation of p38MAPK cascade (GO:1900745)2.20655477
148regulation of extracellular matrix organization (GO:1903053)2.17339661
149negative regulation of osteoblast proliferation (GO:0033689)2.17205106
150low-density lipoprotein particle clearance (GO:0034383)2.16816829
151apoptotic process involved in morphogenesis (GO:0060561)2.16290771
152positive regulation of interferon-alpha production (GO:0032727)2.16121772
153epithelial cell-cell adhesion (GO:0090136)2.16084914
154negative regulation of cell size (GO:0045792)2.15793011
155regulation of endothelial cell chemotaxis (GO:2001026)2.15787522
156cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.15324555
157peptide hormone processing (GO:0016486)2.14229086
158fibroblast migration (GO:0010761)2.13399288
159response to topologically incorrect protein (GO:0035966)2.12775124
160protein N-linked glycosylation (GO:0006487)2.09549306
161coronary vasculature morphogenesis (GO:0060977)2.09348076
162pentose-phosphate shunt (GO:0006098)2.08850815
163astrocyte differentiation (GO:0048708)2.07890465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.48610108
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.03103073
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.45907346
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.01633453
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93059751
6CLOCK_20551151_ChIP-Seq_293T_Human2.88195505
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.71720698
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51198276
9MYC_22102868_ChIP-Seq_BL_Human2.30878244
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.26624826
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15860094
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12476717
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12269418
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11916047
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09430417
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.08293976
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.04819842
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01622105
19ZNF263_19887448_ChIP-Seq_K562_Human2.01573296
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.94395823
21VDR_21846776_ChIP-Seq_THP-1_Human1.89571986
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85665831
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82765377
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80993642
25LXR_22292898_ChIP-Seq_THP-1_Human1.79843164
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79447867
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.75365727
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65947427
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63404425
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61412602
31VDR_24763502_ChIP-Seq_THP-1_Human1.60678193
32TCF7_22412390_ChIP-Seq_EML_Mouse1.59653163
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59598920
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56904168
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56705230
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56327426
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.54134796
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53833293
39FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.51387504
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51036183
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50210897
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49329106
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47562388
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47015259
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46448231
46SPI1_23127762_ChIP-Seq_K562_Human1.44749225
47MAF_26560356_Chip-Seq_TH1_Human1.41949702
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41022848
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38995021
50RACK7_27058665_Chip-Seq_MCF-7_Human1.37367323
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37270805
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36272589
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33946822
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33092328
55* MYB_26560356_Chip-Seq_TH2_Human1.32665439
56UTX_26944678_Chip-Seq_JUKART_Human1.32570600
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31588293
58SOX2_20726797_ChIP-Seq_SW620_Human1.31552485
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30582157
60KDM2B_26808549_Chip-Seq_DND41_Human1.30340827
61* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30253505
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27957483
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27874879
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.27621151
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26964058
66ATF3_27146783_Chip-Seq_COLON_Human1.26572651
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.25272435
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24998467
69TFEB_21752829_ChIP-Seq_HELA_Human1.24481381
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24033600
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23967949
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23016455
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.21701672
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20635592
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20514689
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20038319
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.18873458
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18232157
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17674508
80* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16647598
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15437794
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15248767
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14704891
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14409897
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14127777
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14001521
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11407771
88* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11258172
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09576404
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09510262
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08867870
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08583427
93FOXO3_23340844_ChIP-Seq_DLD1_Human1.08317418
94* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07545966
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07156016
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05723657
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05311111
98GATA6_25053715_ChIP-Seq_YYC3_Human1.05286698
99TP53_22127205_ChIP-Seq_IMR90_Human1.04644661
100LXR_22158963_ChIP-Seq_LIVER_Mouse1.04388998
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02096682
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02096682
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01515412
104* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00562537
105PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00383505
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00065518
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99881025
108GATA4_25053715_ChIP-Seq_YYC3_Human0.99860366
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99854483
110NCOR1_26117541_ChIP-Seq_K562_Human0.99848207
111KDM2B_26808549_Chip-Seq_K562_Human0.99680149
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.99620043
113* SPI1_23547873_ChIP-Seq_NB4_Human0.99439789
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99069484
115TBX20_22080862_ChIP-Seq_HEART_Mouse0.98452575
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.98452575
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97973613
118BRD4_25478319_ChIP-Seq_HGPS_Human0.97674071
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97496644
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97353223
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97240750
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96680941
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96589442
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.96550184
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96421403
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96055947
127SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95426392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.71047906
2MP0003300_gastrointestinal_ulcer3.23022016
3MP0006054_spinal_hemorrhage3.09014507
4MP0009780_abnormal_chondrocyte_physiolo2.92727739
5MP0005058_abnormal_lysosome_morphology2.89508622
6MP0005451_abnormal_body_composition2.63924296
7MP0003172_abnormal_lysosome_physiology2.54242129
8MP0003705_abnormal_hypodermis_morpholog2.53017713
9MP0010030_abnormal_orbit_morphology2.29201056
10MP0008260_abnormal_autophagy2.16127420
11MP0005257_abnormal_intraocular_pressure2.12580295
12MP0002877_abnormal_melanocyte_morpholog2.09532798
13MP0001958_emphysema2.06213658
14MP0003566_abnormal_cell_adhesion2.01569700
15MP0010352_gastrointestinal_tract_polyps1.96258101
16MP0002139_abnormal_hepatobiliary_system1.96064249
17MP0005275_abnormal_skin_tensile1.95109038
18MP0004858_abnormal_nervous_system1.93627124
19MP0003436_decreased_susceptibility_to1.93120916
20MP0000566_synostosis1.83836127
21MP0001533_abnormal_skeleton_physiology1.72982724
22MP0003329_amyloid_beta_deposits1.69732875
23MP0004272_abnormal_basement_membrane1.67473413
24MP0003303_peritoneal_inflammation1.67334312
25MP0002653_abnormal_ependyma_morphology1.64701216
26MP0003283_abnormal_digestive_organ1.62247622
27MP0003279_aneurysm1.62144924
28MP0000013_abnormal_adipose_tissue1.51820719
29MP0005076_abnormal_cell_differentiation1.47624403
30MP0004947_skin_inflammation1.46584007
31MP0000569_abnormal_digit_pigmentation1.45805912
32MP0005220_abnormal_exocrine_pancreas1.44657123
33MP0009278_abnormal_bone_marrow1.44051905
34MP0005023_abnormal_wound_healing1.43767056
35* MP0003183_abnormal_peptide_metabolism1.42688211
36MP0005623_abnormal_meninges_morphology1.42316688
37MP0005365_abnormal_bile_salt1.37475812
38MP0005164_abnormal_response_to1.30613004
39MP0009840_abnormal_foam_cell1.29999285
40MP0003075_altered_response_to1.29720511
41MP0002419_abnormal_innate_immunity1.29690651
42MP0004264_abnormal_extraembryonic_tissu1.29076144
43MP0005390_skeleton_phenotype1.24745759
44MP0000003_abnormal_adipose_tissue1.24469884
45MP0010368_abnormal_lymphatic_system1.23214333
46MP0000858_altered_metastatic_potential1.21967717
47MP0001835_abnormal_antigen_presentation1.21578545
48MP0001542_abnormal_bone_strength1.20409834
49MP0009384_cardiac_valve_regurgitation1.19703085
50MP0005503_abnormal_tendon_morphology1.19355685
51MP0002166_altered_tumor_susceptibility1.19320780
52MP0008961_abnormal_basal_metabolism1.18551201
53MP0000751_myopathy1.18367218
54MP0002998_abnormal_bone_remodeling1.13779948
55MP0002933_joint_inflammation1.13722163
56MP0002089_abnormal_postnatal_growth/wei1.12508952
57MP0003091_abnormal_cell_migration1.11993452
58MP0006082_CNS_inflammation1.10453109
59MP0005508_abnormal_skeleton_morphology1.09761470
60MP0000685_abnormal_immune_system1.08921741
61MP0002896_abnormal_bone_mineralization1.07000254
62MP0010155_abnormal_intestine_physiology1.05103090
63MP0003795_abnormal_bone_structure1.04398936
64MP0005360_urolithiasis1.03364634
65MP0005464_abnormal_platelet_physiology1.03351979
66MP0004883_abnormal_blood_vessel1.02584080
67MP0001944_abnormal_pancreas_morphology1.02078601
68MP0001873_stomach_inflammation1.00812091
69MP0003045_fibrosis1.00252405
70MP0003115_abnormal_respiratory_system0.99823953
71MP0009053_abnormal_anal_canal0.99621351
72MP0005409_darkened_coat_color0.98713508
73MP0001756_abnormal_urination0.98657152
74MP0010234_abnormal_vibrissa_follicle0.98272907
75MP0003448_altered_tumor_morphology0.96688308
76MP0002909_abnormal_adrenal_gland0.96580952
77MP0002060_abnormal_skin_morphology0.94737090
78MP0000343_altered_response_to0.94239654
79MP0001243_abnormal_dermal_layer0.94230305
80MP0005000_abnormal_immune_tolerance0.93677982
81MP0000767_abnormal_smooth_muscle0.92248689
82MP0003191_abnormal_cellular_cholesterol0.92155772
83MP0001849_ear_inflammation0.91675703
84MP0009643_abnormal_urine_homeostasis0.91459657
85MP0000920_abnormal_myelination0.91167742
86MP0010386_abnormal_urinary_bladder0.90960687
87MP0001845_abnormal_inflammatory_respons0.90535350
88MP0000733_abnormal_muscle_development0.89930054
89MP0000678_abnormal_parathyroid_gland0.88952066
90MP0002234_abnormal_pharynx_morphology0.88673506
91MP0000538_abnormal_urinary_bladder0.88257135
92MP0003453_abnormal_keratinocyte_physiol0.87908870
93MP0002006_tumorigenesis0.87631923
94MP0000371_diluted_coat_color0.87157354
95MP0002452_abnormal_antigen_presenting0.87109523
96MP0005025_abnormal_response_to0.86980154
97MP0001661_extended_life_span0.86687653
98MP0004134_abnormal_chest_morphology0.86555573
99MP0002405_respiratory_system_inflammati0.85832550
100MP0005165_increased_susceptibility_to0.84576692
101MP0003724_increased_susceptibility_to0.84076187
102MP0005408_hypopigmentation0.84028623
103MP0005310_abnormal_salivary_gland0.83823730
104MP0000604_amyloidosis0.83702136
105MP0001915_intracranial_hemorrhage0.83364155
106MP0004808_abnormal_hematopoietic_stem0.83201519
107MP0010329_abnormal_lipoprotein_level0.83103881
108MP0005387_immune_system_phenotype0.81388978
109MP0001790_abnormal_immune_system0.81388978
110MP0009785_altered_susceptibility_to0.80691286
111MP0000163_abnormal_cartilage_morphology0.80074307
112MP0003690_abnormal_glial_cell0.79839078
113MP0008469_abnormal_protein_level0.79444383
114MP0000428_abnormal_craniofacial_morphol0.79178255
115MP0002295_abnormal_pulmonary_circulatio0.78463633
116MP0003828_pulmonary_edema0.78151478
117MP0002148_abnormal_hypersensitivity_rea0.76486512
118MP0000249_abnormal_blood_vessel0.76057903
119MP0002113_abnormal_skeleton_development0.75813075
120MP0004233_abnormal_muscle_weight0.74922901
121MP0000490_abnormal_crypts_of0.74657672
122MP0002132_abnormal_respiratory_system0.74224882
123MP0001666_abnormal_nutrient_absorption0.73963361
124MP0002135_abnormal_kidney_morphology0.73569083
125* MP0001614_abnormal_blood_vessel0.72407766
126MP0002693_abnormal_pancreas_physiology0.72336492
127MP0003942_abnormal_urinary_system0.71807163
128MP0001299_abnormal_eye_distance/0.71591863
129MP0003122_maternal_imprinting0.70154499
130MP0005621_abnormal_cell_physiology0.70023140
131MP0005248_abnormal_Harderian_gland0.69514899
132MP0005197_abnormal_uvea_morphology0.69414034
133MP0005171_absent_coat_pigmentation0.69199497
134MP0003656_abnormal_erythrocyte_physiolo0.68078271
135MP0000609_abnormal_liver_physiology0.68044469
136MP0004782_abnormal_surfactant_physiolog0.66452009
137MP0001545_abnormal_hematopoietic_system0.66286009
138MP0005397_hematopoietic_system_phenotyp0.66286009
139* MP0003634_abnormal_glial_cell0.65229287
140MP0005085_abnormal_gallbladder_physiolo0.64512866
141MP0009763_increased_sensitivity_to0.64474742
142MP0000681_abnormal_thyroid_gland0.64348236
143MP0005375_adipose_tissue_phenotype0.63276832

Predicted human phenotypes

RankGene SetZ-score
1Dysostosis multiplex (HP:0000943)3.96696287
2Protrusio acetabuli (HP:0003179)3.70268689
3Urinary glycosaminoglycan excretion (HP:0003541)3.69475467
4Mucopolysacchariduria (HP:0008155)3.69475467
5Cerebral aneurysm (HP:0004944)3.58343948
6Vacuolated lymphocytes (HP:0001922)3.51346419
7Abnormality of mucopolysaccharide metabolism (HP:0011020)3.51072084
8Abnormality of polysaccharide metabolism (HP:0011012)3.51072084
9Abnormality of glycosaminoglycan metabolism (HP:0004371)3.51072084
10Aortic aneurysm (HP:0004942)3.38443239
11Increased cerebral lipofuscin (HP:0011813)3.30666512
12Cervical subluxation (HP:0003308)3.13733237
13Deep venous thrombosis (HP:0002625)3.10453250
14Aortic dissection (HP:0002647)3.01388411
15Spondylolisthesis (HP:0003302)2.98524639
16Arterial tortuosity (HP:0005116)2.81551739
17Increased neuronal autofluorescent lipopigment (HP:0002074)2.80884747
18Hand muscle atrophy (HP:0009130)2.80080782
19Vascular tortuosity (HP:0004948)2.71442575
20Premature rupture of membranes (HP:0001788)2.69035582
21Abnormality of glycolipid metabolism (HP:0010969)2.68478796
22Abnormality of liposaccharide metabolism (HP:0010968)2.68478796
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.68478796
24Systemic lupus erythematosus (HP:0002725)2.61410041
25Aneurysm (HP:0002617)2.60924640
26Striae distensae (HP:0001065)2.56725295
27Vertebral compression fractures (HP:0002953)2.54216887
28Amyloidosis (HP:0011034)2.53177281
29Myocardial infarction (HP:0001658)2.43870194
30Severe short stature (HP:0003510)2.40695827
31Thin bony cortex (HP:0002753)2.38167429
32Shallow orbits (HP:0000586)2.35063449
33Abnormality of macrophages (HP:0004311)2.34749214
34Eczematoid dermatitis (HP:0000976)2.33882471
35Neurofibrillary tangles (HP:0002185)2.33682849
36Peritonitis (HP:0002586)2.33044398
37Short nail (HP:0001799)2.32702195
38Interstitial pulmonary disease (HP:0006530)2.27173035
39Periodontitis (HP:0000704)2.25228805
40Biconcave vertebral bodies (HP:0004586)2.24895273
41Distal upper limb amyotrophy (HP:0007149)2.23822384
42Upper limb amyotrophy (HP:0009129)2.23822384
43Long toe (HP:0010511)2.23684125
44Abnormality of complement system (HP:0005339)2.23354406
45Dilatation of the ascending aorta (HP:0005111)2.19739713
46Flat acetabular roof (HP:0003180)2.18219055
47Neonatal short-limb short stature (HP:0008921)2.17317364
48Atrophic scars (HP:0001075)2.16545079
49Complement deficiency (HP:0004431)2.13472475
50Upper motor neuron abnormality (HP:0002127)2.13081135
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.12659695
52Cholecystitis (HP:0001082)2.07171249
53Abnormal gallbladder physiology (HP:0012438)2.07171249
54Bladder diverticulum (HP:0000015)2.06901449
55Abnormality of the lumbar spine (HP:0100712)2.06687390
56Abnormality of the acetabulum (HP:0003170)2.06563534
57Follicular hyperkeratosis (HP:0007502)2.03413752
58Nuclear cataract (HP:0100018)2.00585677
59Asymmetric septal hypertrophy (HP:0001670)1.99399081
60Camptodactyly of toe (HP:0001836)1.98886325
61Spinal rigidity (HP:0003306)1.98649232
62Abnormality of skull ossification (HP:0002703)1.97967953
63Recurrent abscess formation (HP:0002722)1.97337872
64Cardiovascular calcification (HP:0011915)1.94676002
65Broad face (HP:0000283)1.94294691
66Abnormal delivery (HP:0001787)1.92808418
67Soft skin (HP:0000977)1.91220312
68Hemorrhage of the eye (HP:0011885)1.91103962
69Ankle contracture (HP:0006466)1.89391877
70Increased variability in muscle fiber diameter (HP:0003557)1.89376385
71Neonatal death (HP:0003811)1.86996774
72Coxa vara (HP:0002812)1.86827787
73Joint stiffness (HP:0001387)1.85861336
74Esophageal varix (HP:0002040)1.85720020
75Right ventricular cardiomyopathy (HP:0011663)1.85640537
76Xanthomatosis (HP:0000991)1.85295429
77Nonimmune hydrops fetalis (HP:0001790)1.84566802
78Purpura (HP:0000979)1.84329114
79Cerebral inclusion bodies (HP:0100314)1.84038007
80Joint laxity (HP:0001388)1.82316945
81Abnormality of the right ventricle (HP:0001707)1.81653591
82Hematochezia (HP:0002573)1.78410337
83Hypercortisolism (HP:0001578)1.78283930
84Retinal atrophy (HP:0001105)1.77622882
85Abnormality of the Achilles tendon (HP:0005109)1.77030174
86Glomerulonephritis (HP:0000099)1.76351576
87Blue sclerae (HP:0000592)1.76176908
88Disproportionate short-trunk short stature (HP:0003521)1.76066859
89Mitral stenosis (HP:0001718)1.75870865
90J-shaped sella turcica (HP:0002680)1.75756501
91Pathologic fracture (HP:0002756)1.75554732
92Broad metatarsal (HP:0001783)1.75119029
93Osteopenia (HP:0000938)1.75117011
94Platyspondyly (HP:0000926)1.74943083
95Abnormality of the common coagulation pathway (HP:0010990)1.74825597
96Joint hemorrhage (HP:0005261)1.74100794
97Abnormality of dentin (HP:0010299)1.73569589
98Vascular calcification (HP:0004934)1.73524620
99Gingival bleeding (HP:0000225)1.73216413
100Polycythemia (HP:0001901)1.72901434
101Back pain (HP:0003418)1.72841791
102Abnormality of skeletal muscle fiber size (HP:0012084)1.72648849
103Beaking of vertebral bodies (HP:0004568)1.72485369
104Abnormality of carpal bone ossification (HP:0006257)1.71868389
105Achilles tendon contracture (HP:0001771)1.71572769
106Increased connective tissue (HP:0009025)1.71462425
107Spinal canal stenosis (HP:0003416)1.71117675
108Hypercholesterolemia (HP:0003124)1.71067850
109Exostoses (HP:0100777)1.71044274
110Elevated erythrocyte sedimentation rate (HP:0003565)1.70766317
111Osteoarthritis (HP:0002758)1.70122637
112Hyperextensible skin (HP:0000974)1.70012596
113Cardiomegaly (HP:0001640)1.70007184
114Growth hormone excess (HP:0000845)1.69825810
115Fragile skin (HP:0001030)1.69607600
116Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69483682
117Cupped ribs (HP:0000887)1.69351320
118Abnormality of the odontoid process (HP:0003310)1.68887526
119Gingivitis (HP:0000230)1.68818643
120Myositis (HP:0100614)1.67748276
121Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66764110
122Abnormality of the anterior horn cell (HP:0006802)1.66686065
123Degeneration of anterior horn cells (HP:0002398)1.66686065
124Recurrent bacterial skin infections (HP:0005406)1.66676345
125Genu recurvatum (HP:0002816)1.66315822
126Skin nodule (HP:0200036)1.65131202
127Autoimmune thrombocytopenia (HP:0001973)1.65010702
128Increased density of long bones (HP:0006392)1.64919737
129Hallux valgus (HP:0001822)1.64116023
130Congenital glaucoma (HP:0001087)1.63947701
131Abnormal ossification of hand bones (HP:0005921)1.63934666
132Spinal muscular atrophy (HP:0007269)1.63744327
133Mitral valve prolapse (HP:0001634)1.63313896
134Abnormality of the peritoneum (HP:0002585)1.63197509
135Protuberant abdomen (HP:0001538)1.63123447
136Wormian bones (HP:0002645)1.62942131
137Progressive neurologic deterioration (HP:0002344)1.62610138
138Deviation of the hallux (HP:0010051)1.62224747
139Lymphangioma (HP:0100764)1.61303086
140Disproportionate tall stature (HP:0001519)1.60525533
141Hypoglycemic seizures (HP:0002173)1.59170778
142Bicuspid aortic valve (HP:0001647)1.58224882
143Ovoid vertebral bodies (HP:0003300)1.57878075
144Recurrent gram-negative bacterial infections (HP:0005420)1.56485728
145Joint contractures involving the joints of the feet (HP:0100492)1.55259553
146Flexion contracture of toe (HP:0005830)1.55259553
147Osteolytic defects of the hand bones (HP:0009699)1.54982450
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.54982450
149Loss of speech (HP:0002371)1.54355022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.85969153
2TRIB33.70941084
3EPHA33.03510064
4PKN22.58872676
5PRPF4B2.19272778
6SIK12.19131677
7TESK12.10756798
8FGFR32.05368470
9PTK62.00100541
10RIPK11.97093282
11MAP3K101.94485036
12FGFR41.90360671
13ICK1.82180748
14MAPK151.80276338
15NTRK11.80236389
16TGFBR21.77418636
17TBK11.76736688
18PDGFRA1.72867587
19PIK3CG1.68428539
20TTN1.67926183
21MET1.58363937
22PAK41.57892079
23MST1R1.54828043
24SIK31.45914047
25EEF2K1.44679200
26EPHB21.44451247
27FLT31.40675775
28MOS1.39933541
29ZAP701.38849408
30TYK21.36533403
31SMG11.34698069
32KSR21.33901244
33LRRK21.33823475
34PRKD21.29116465
35PASK1.28626162
36PTK21.28139650
37EPHB11.26346394
38EPHA21.22398338
39IRAK31.22116051
40TAOK31.20992239
41STK101.18541728
42MAP3K61.18205864
43KIT1.18091964
44JAK31.15760277
45MAP4K11.15599281
46JAK11.13327014
47INSRR1.12582306
48ARAF1.10304981
49FGFR11.07119132
50DYRK1B1.05568471
51CDK121.04029293
52IRAK41.02803155
53TGFBR11.01642334
54FER0.99784965
55TESK20.96839337
56LMTK20.96632373
57CHUK0.93197147
58MAP3K30.91109632
59FGR0.90853771
60ERBB30.90302228
61BTK0.88594463
62MAP3K10.88401379
63SCYL20.88384931
64ITK0.86458728
65TAOK20.86223005
66LIMK10.85646876
67RIPK40.85634651
68KDR0.83623341
69LATS10.83010980
70RPS6KA40.81474427
71CAMK1D0.81195995
72RPS6KA20.81145608
73MAP2K30.80928524
74MAPKAPK30.80532032
75BLK0.79225697
76MAPK70.78547158
77CSK0.78036479
78DDR20.77473876
79PDPK10.76551182
80MAP3K130.75715564
81MAP3K110.75182936
82MTOR0.74225176
83IKBKE0.73808413
84PAK30.73789171
85CSF1R0.73782660
86MAP3K140.73612991
87BRD40.73374947
88NEK90.73106623
89FRK0.72820914
90HIPK20.71875148
91STK380.71596153
92ERBB20.69644459
93JAK20.66333991
94BMX0.65490949
95MAP3K20.65407545
96PRKG20.64391037
97PDK20.63346131
98MAPK110.63103139
99PAK20.60376486
100CLK10.60133389
101PRKCH0.59549539
102ROCK20.57230371
103MYLK0.56934468
104MAP3K50.56848568
105GRK70.56830492
106PIM20.56387359
107CDK60.55105610
108MAP2K20.55021786
109PDGFRB0.54603238
110MAPKAPK20.52392206
111BUB10.52122575
112DMPK0.51901868
113KSR10.51424459
114WNK30.50421142
115PRKD30.49197225
116RPS6KA60.48393641
117RPS6KC10.48339708
118RPS6KL10.48339708
119YES10.47312907
120ERBB40.47283138
121GRK60.46978734
122CDC42BPA0.46695398
123NME20.46592285
124MAP2K10.46257984
125SRC0.45778765
126IRAK10.45758972
127CDK80.44958932
128CAMK1G0.43635325
129MARK20.42712229
130MATK0.42255671
131TRPM70.41546046
132ROCK10.41197849
133RET0.40187405
134ILK0.40185428
135PRKD10.39967459
136IGF1R0.39636943
137LATS20.38585251
138FYN0.36171951
139MAP3K80.35829352

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.79996543
2Lysosome_Homo sapiens_hsa041422.70200370
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.44576222
4Other glycan degradation_Homo sapiens_hsa005112.28842071
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06307901
6Leishmaniasis_Homo sapiens_hsa051401.92373933
7N-Glycan biosynthesis_Homo sapiens_hsa005101.80664691
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.76024635
9Legionellosis_Homo sapiens_hsa051341.63517123
10Fructose and mannose metabolism_Homo sapiens_hsa000511.53721136
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53035670
12Chronic myeloid leukemia_Homo sapiens_hsa052201.47473702
13Antigen processing and presentation_Homo sapiens_hsa046121.44337892
14Pentose phosphate pathway_Homo sapiens_hsa000301.42627236
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.40215718
16Osteoclast differentiation_Homo sapiens_hsa043801.39477151
17Staphylococcus aureus infection_Homo sapiens_hsa051501.37890386
18Toxoplasmosis_Homo sapiens_hsa051451.36910508
19Phagosome_Homo sapiens_hsa041451.33932827
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33438623
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33338481
22Vibrio cholerae infection_Homo sapiens_hsa051101.32187300
23Pertussis_Homo sapiens_hsa051331.29647370
24Bladder cancer_Homo sapiens_hsa052191.28901051
25* Notch signaling pathway_Homo sapiens_hsa043301.28225699
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25271017
27Shigellosis_Homo sapiens_hsa051311.23371725
28Amoebiasis_Homo sapiens_hsa051461.22946012
29Pancreatic cancer_Homo sapiens_hsa052121.22762576
30Focal adhesion_Homo sapiens_hsa045101.22739931
31Proteoglycans in cancer_Homo sapiens_hsa052051.22323061
32Apoptosis_Homo sapiens_hsa042101.15987665
33Adherens junction_Homo sapiens_hsa045201.15701502
34TNF signaling pathway_Homo sapiens_hsa046681.14529755
35Tuberculosis_Homo sapiens_hsa051521.13709633
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12696893
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12509300
38Small cell lung cancer_Homo sapiens_hsa052221.12073965
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09228191
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08780303
41Renin-angiotensin system_Homo sapiens_hsa046141.05419656
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05252777
43Viral myocarditis_Homo sapiens_hsa054161.04732671
44ECM-receptor interaction_Homo sapiens_hsa045121.03297973
45Malaria_Homo sapiens_hsa051441.01662219
46Prion diseases_Homo sapiens_hsa050201.01563502
47Fatty acid elongation_Homo sapiens_hsa000621.01478037
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01416627
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01019268
50PPAR signaling pathway_Homo sapiens_hsa033201.00139696
51Galactose metabolism_Homo sapiens_hsa000520.99530622
52Insulin resistance_Homo sapiens_hsa049310.98228397
53Carbon metabolism_Homo sapiens_hsa012000.97511658
54Influenza A_Homo sapiens_hsa051640.96431808
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94885425
56Hepatitis B_Homo sapiens_hsa051610.94667789
57Measles_Homo sapiens_hsa051620.93136593
58Biosynthesis of amino acids_Homo sapiens_hsa012300.92731100
59Sphingolipid metabolism_Homo sapiens_hsa006000.92549502
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.92097998
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.91955029
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.90553574
63Selenocompound metabolism_Homo sapiens_hsa004500.89915477
64Acute myeloid leukemia_Homo sapiens_hsa052210.88256819
65Sulfur metabolism_Homo sapiens_hsa009200.87328422
66Colorectal cancer_Homo sapiens_hsa052100.87023808
67Salmonella infection_Homo sapiens_hsa051320.85663952
68Endometrial cancer_Homo sapiens_hsa052130.85429756
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.83011766
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80324722
71B cell receptor signaling pathway_Homo sapiens_hsa046620.79789188
72MicroRNAs in cancer_Homo sapiens_hsa052060.79114027
73Prolactin signaling pathway_Homo sapiens_hsa049170.77521655
74Protein digestion and absorption_Homo sapiens_hsa049740.73914925
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73751357
76Hepatitis C_Homo sapiens_hsa051600.72883482
77Endocytosis_Homo sapiens_hsa041440.72777939
78Rheumatoid arthritis_Homo sapiens_hsa053230.71686504
79Lysine degradation_Homo sapiens_hsa003100.71033992
80Hematopoietic cell lineage_Homo sapiens_hsa046400.70594872
81HTLV-I infection_Homo sapiens_hsa051660.70373867
82Fatty acid metabolism_Homo sapiens_hsa012120.69059333
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66911198
84Caffeine metabolism_Homo sapiens_hsa002320.66121530
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65564020
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.63758265
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.63191007
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62331174
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61720971
90Hippo signaling pathway_Homo sapiens_hsa043900.61358422
91Thyroid cancer_Homo sapiens_hsa052160.61198407
92Platelet activation_Homo sapiens_hsa046110.60666081
93Protein export_Homo sapiens_hsa030600.60641628
94Fatty acid degradation_Homo sapiens_hsa000710.60288678
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59862413
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59406235
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59271825
98Type II diabetes mellitus_Homo sapiens_hsa049300.59046848
99Complement and coagulation cascades_Homo sapiens_hsa046100.58875321
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58783343
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56753835
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56303675
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56128175
104Herpes simplex infection_Homo sapiens_hsa051680.55582773
105Renal cell carcinoma_Homo sapiens_hsa052110.55211145
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55182103
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54077947
108Basal cell carcinoma_Homo sapiens_hsa052170.52554836
109Starch and sucrose metabolism_Homo sapiens_hsa005000.51899131
110Glutathione metabolism_Homo sapiens_hsa004800.50326294
111Viral carcinogenesis_Homo sapiens_hsa052030.49846259
112Prostate cancer_Homo sapiens_hsa052150.49653173
113Steroid biosynthesis_Homo sapiens_hsa001000.49524859
114mTOR signaling pathway_Homo sapiens_hsa041500.48596125
115Non-small cell lung cancer_Homo sapiens_hsa052230.48268254
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47261425
117Chemokine signaling pathway_Homo sapiens_hsa040620.46928973
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.46555270
119HIF-1 signaling pathway_Homo sapiens_hsa040660.46304929
120Phenylalanine metabolism_Homo sapiens_hsa003600.46298647
121Pathways in cancer_Homo sapiens_hsa052000.46183712
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.45037990
123Insulin signaling pathway_Homo sapiens_hsa049100.44840574
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44633415
125Arginine biosynthesis_Homo sapiens_hsa002200.43612521
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39857935
127VEGF signaling pathway_Homo sapiens_hsa043700.37602493
128Thyroid hormone synthesis_Homo sapiens_hsa049180.35149601
129Fat digestion and absorption_Homo sapiens_hsa049750.33348097

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