NDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.01428784
2DNA replication initiation (GO:0006270)5.44943054
3protein localization to kinetochore (GO:0034501)5.40886077
4DNA strand elongation involved in DNA replication (GO:0006271)5.27927734
5telomere maintenance via semi-conservative replication (GO:0032201)5.13694729
6DNA strand elongation (GO:0022616)4.99206657
7* nuclear pore organization (GO:0006999)4.82297295
8DNA replication checkpoint (GO:0000076)4.80317325
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.76821024
10establishment of integrated proviral latency (GO:0075713)4.76035917
11* nuclear pore complex assembly (GO:0051292)4.67102476
12telomere maintenance via recombination (GO:0000722)4.60197965
13mitotic recombination (GO:0006312)4.58978019
14protein localization to chromosome, centromeric region (GO:0071459)4.58235896
15CENP-A containing nucleosome assembly (GO:0034080)4.49499553
16chromatin remodeling at centromere (GO:0031055)4.46333646
17mitotic nuclear envelope disassembly (GO:0007077)4.39250907
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.38130670
19mitotic chromosome condensation (GO:0007076)4.34174388
20kinetochore organization (GO:0051383)4.33914972
21sister chromatid segregation (GO:0000819)4.32530858
22mitotic metaphase plate congression (GO:0007080)4.32408161
23DNA replication-independent nucleosome organization (GO:0034724)4.26631149
24DNA replication-independent nucleosome assembly (GO:0006336)4.26631149
25mitotic sister chromatid segregation (GO:0000070)4.22299764
26attachment of spindle microtubules to kinetochore (GO:0008608)4.14339436
27telomere maintenance via telomere lengthening (GO:0010833)4.13228869
28DNA replication-dependent nucleosome organization (GO:0034723)4.12124617
29DNA replication-dependent nucleosome assembly (GO:0006335)4.12124617
30membrane disassembly (GO:0030397)4.09273453
31nuclear envelope disassembly (GO:0051081)4.09273453
32mitotic sister chromatid cohesion (GO:0007064)4.06428554
33regulation of nuclear cell cycle DNA replication (GO:0033262)4.04035994
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.02914091
35regulation of spindle organization (GO:0090224)3.98189432
36nucleotide-excision repair, DNA gap filling (GO:0006297)3.95388488
37folic acid-containing compound biosynthetic process (GO:0009396)3.90768115
38nucleobase biosynthetic process (GO:0046112)3.88798430
39double-strand break repair via nonhomologous end joining (GO:0006303)3.87960173
40non-recombinational repair (GO:0000726)3.87960173
41DNA geometric change (GO:0032392)3.87874910
42DNA duplex unwinding (GO:0032508)3.87626019
43metaphase plate congression (GO:0051310)3.86781021
44DNA ligation (GO:0006266)3.84341455
45histone exchange (GO:0043486)3.79011166
46spindle checkpoint (GO:0031577)3.77462802
47IMP biosynthetic process (GO:0006188)3.73225708
48spindle assembly checkpoint (GO:0071173)3.68756834
49regulation of translational fidelity (GO:0006450)3.65371985
50negative regulation of chromosome segregation (GO:0051985)3.64506894
51regulation of chromosome segregation (GO:0051983)3.62930702
52kinetochore assembly (GO:0051382)3.62898900
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.62221080
54negative regulation of sister chromatid segregation (GO:0033046)3.62221080
55negative regulation of mitotic sister chromatid separation (GO:2000816)3.62221080
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.62221080
57regulation of sister chromatid cohesion (GO:0007063)3.61198554
58mitotic spindle assembly checkpoint (GO:0007094)3.59834655
59chromatin assembly or disassembly (GO:0006333)3.59627581
60regulation of centriole replication (GO:0046599)3.59371099
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.58568310
62establishment of chromosome localization (GO:0051303)3.54803220
63mitotic spindle checkpoint (GO:0071174)3.53664150
64negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.53289414
65regulation of mitotic metaphase/anaphase transition (GO:0030071)3.49923786
66formation of translation preinitiation complex (GO:0001731)3.49708931
67establishment of viral latency (GO:0019043)3.48707867
68purine nucleobase biosynthetic process (GO:0009113)3.47924670
69meiotic chromosome segregation (GO:0045132)3.47161622
70* pore complex assembly (GO:0046931)3.46800564
71regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.43301528
72regulation of centrosome cycle (GO:0046605)3.40489131
73regulation of mitotic spindle organization (GO:0060236)3.39825219
74translesion synthesis (GO:0019985)3.35935466
75positive regulation of chromosome segregation (GO:0051984)3.34887296
76IMP metabolic process (GO:0046040)3.34604999
77maturation of SSU-rRNA (GO:0030490)3.33289375
78negative regulation of RNA splicing (GO:0033119)3.33175606
79protein localization to chromosome (GO:0034502)3.30883436
80DNA deamination (GO:0045006)3.30245650
81chromosome segregation (GO:0007059)3.29617101
82nuclear envelope organization (GO:0006998)3.29548114
83regulation of mitotic sister chromatid separation (GO:0010965)3.28947081
84regulation of mitotic sister chromatid segregation (GO:0033047)3.28947081
85regulation of sister chromatid segregation (GO:0033045)3.28947081
86DNA conformation change (GO:0071103)3.25767709
87regulation of helicase activity (GO:0051095)3.25329867
88ribosome assembly (GO:0042255)3.23037052
89DNA packaging (GO:0006323)3.22378796
90somatic hypermutation of immunoglobulin genes (GO:0016446)3.17636085
91somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17636085
92positive regulation of mitotic sister chromatid separation (GO:1901970)3.14280484
93positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14280484
94positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14280484
95negative regulation of mRNA processing (GO:0050686)3.14011083
96ribosomal small subunit assembly (GO:0000028)3.13864214
97ATP-dependent chromatin remodeling (GO:0043044)3.12952245
98heterochromatin organization (GO:0070828)3.12202650
99telomere maintenance (GO:0000723)3.11657895
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.11487788
101base-excision repair (GO:0006284)3.10377399
102telomere organization (GO:0032200)3.10192401
103chromosome condensation (GO:0030261)3.09900984
104L-serine metabolic process (GO:0006563)3.09556483
105ribosome biogenesis (GO:0042254)3.08974374
106mitotic G2/M transition checkpoint (GO:0044818)3.08733510
107histone-serine phosphorylation (GO:0035404)3.06926329
108DNA topological change (GO:0006265)3.04806882
109DNA strand renaturation (GO:0000733)3.04412631
110mitotic cell cycle (GO:0000278)3.04327315
111regulation of DNA endoreduplication (GO:0032875)3.03162585
112DNA double-strand break processing (GO:0000729)3.01112778
113* protein complex localization (GO:0031503)2.98984060
114tRNA aminoacylation for protein translation (GO:0006418)2.98584604
115negative regulation of mitosis (GO:0045839)2.97455998
116pre-miRNA processing (GO:0031054)2.96131963
117postreplication repair (GO:0006301)2.96086794
118regulation of centrosome duplication (GO:0010824)2.95958393
119DNA synthesis involved in DNA repair (GO:0000731)2.95920416
120mismatch repair (GO:0006298)2.94834594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.58570503
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.50556845
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.14567143
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.71156959
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41709330
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03895625
7AR_21909140_ChIP-Seq_LNCAP_Human2.93497241
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80154410
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59716730
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56489477
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.51308826
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.45312499
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43943080
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.37292673
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33430988
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.31373697
17XRN2_22483619_ChIP-Seq_HELA_Human2.29259336
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23281077
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23183080
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.21348230
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17818580
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13937128
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08663825
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02679050
25E2F7_22180533_ChIP-Seq_HELA_Human10.6650294
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96124177
27VDR_23849224_ChIP-Seq_CD4+_Human1.92194409
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78358628
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76320578
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75216995
31TTF2_22483619_ChIP-Seq_HELA_Human1.74183240
32FOXP3_21729870_ChIP-Seq_TREG_Human1.74105600
33DCP1A_22483619_ChIP-Seq_HELA_Human1.67929186
34MYC_22102868_ChIP-Seq_BL_Human1.62927371
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62514935
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58689656
37GABP_19822575_ChIP-Seq_HepG2_Human1.57054537
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54582439
39CIITA_25753668_ChIP-Seq_RAJI_Human1.54549145
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54306627
41ELK1_19687146_ChIP-ChIP_HELA_Human1.53867569
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52745634
43KDM5A_27292631_Chip-Seq_BREAST_Human1.52444755
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51593923
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51385645
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41097726
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34741897
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33779630
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32676722
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32457218
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31465244
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31211769
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30646184
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30520809
55E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28110956
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23347494
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21022056
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.19615150
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19039027
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18680918
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17983947
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17800431
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16934669
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12200707
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11797325
66SOX17_20123909_ChIP-Seq_XEN_Mouse1.11128467
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.10870454
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09993609
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08579544
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08452360
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.05554678
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04807475
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04419343
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02873400
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02407460
76SALL1_21062744_ChIP-ChIP_HESCs_Human0.99436689
77TFEB_21752829_ChIP-Seq_HELA_Human0.98674753
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98246392
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97317005
80VDR_21846776_ChIP-Seq_THP-1_Human0.97314709
81SOX2_16153702_ChIP-ChIP_HESCs_Human0.97246844
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94249416
83MYC_18940864_ChIP-ChIP_HL60_Human0.94115694
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92493135
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90757394
86NANOG_21062744_ChIP-ChIP_HESCs_Human0.89876378
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89442270
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89357065
89TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89184001
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88837014
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88609216
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88538101
93TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87147606
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86442183
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85696483
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85395489
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82614349
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81837111
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81582665
100ZNF263_19887448_ChIP-Seq_K562_Human0.80716284
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80381688
102SRF_21415370_ChIP-Seq_HL-1_Mouse0.79558866
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79482252
104CHD1_26751641_Chip-Seq_LNCaP_Human0.78174716
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77610412
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.74075965
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73658298
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73419592
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73413412
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73034506
111SPI1_23547873_ChIP-Seq_NB4_Human0.72505958
112CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72472602
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71782069
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71660159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.86185312
2MP0010094_abnormal_chromosome_stability4.80827455
3MP0003693_abnormal_embryo_hatching4.55468140
4MP0004957_abnormal_blastocyst_morpholog4.26159531
5MP0008057_abnormal_DNA_replication4.18705826
6MP0003077_abnormal_cell_cycle4.01642055
7MP0010352_gastrointestinal_tract_polyps3.18242845
8MP0008058_abnormal_DNA_repair3.08717347
9MP0008932_abnormal_embryonic_tissue3.03858484
10MP0002396_abnormal_hematopoietic_system2.81878446
11MP0008007_abnormal_cellular_replicative2.79097251
12MP0001730_embryonic_growth_arrest2.39012323
13MP0003123_paternal_imprinting2.31306150
14MP0000350_abnormal_cell_proliferation2.30524019
15MP0010307_abnormal_tumor_latency2.07818744
16MP0005076_abnormal_cell_differentiation1.96019009
17MP0003705_abnormal_hypodermis_morpholog1.93178657
18MP0001672_abnormal_embryogenesis/_devel1.91836642
19MP0005380_embryogenesis_phenotype1.91836642
20MP0010030_abnormal_orbit_morphology1.88292379
21MP0001697_abnormal_embryo_size1.84812050
22MP0010234_abnormal_vibrissa_follicle1.80653651
23MP0008877_abnormal_DNA_methylation1.75849977
24MP0004197_abnormal_fetal_growth/weight/1.74567335
25MP0009697_abnormal_copulation1.71914700
26MP0003984_embryonic_growth_retardation1.71558971
27MP0000490_abnormal_crypts_of1.71133145
28MP0003121_genomic_imprinting1.68300369
29MP0002088_abnormal_embryonic_growth/wei1.67027675
30MP0002080_prenatal_lethality1.66117137
31MP0002085_abnormal_embryonic_tissue1.64305026
32MP0002084_abnormal_developmental_patter1.63654851
33MP0009053_abnormal_anal_canal1.57858023
34MP0002009_preneoplasia1.56194758
35MP0000537_abnormal_urethra_morphology1.55586540
36MP0002086_abnormal_extraembryonic_tissu1.54543088
37MP0002877_abnormal_melanocyte_morpholog1.52712958
38MP0003786_premature_aging1.45402086
39MP0003303_peritoneal_inflammation1.44378922
40MP0009672_abnormal_birth_weight1.39860893
41MP0002697_abnormal_eye_size1.36811567
42MP0004808_abnormal_hematopoietic_stem1.36518789
43MP0003567_abnormal_fetal_cardiomyocyte1.33006330
44MP0002019_abnormal_tumor_incidence1.31590110
45MP0003890_abnormal_embryonic-extraembry1.29709517
46MP0000313_abnormal_cell_death1.29392206
47MP0006292_abnormal_olfactory_placode1.28772946
48MP0003718_maternal_effect1.26140960
49MP0001661_extended_life_span1.23484742
50MP0003119_abnormal_digestive_system1.20900888
51MP0006054_spinal_hemorrhage1.19124661
52MP0002210_abnormal_sex_determination1.16109281
53MP0002111_abnormal_tail_morphology1.15350690
54MP0003937_abnormal_limbs/digits/tail_de1.12043474
55MP0000465_gastrointestinal_hemorrhage1.09754191
56MP0009703_decreased_birth_body1.09506186
57MP0000428_abnormal_craniofacial_morphol1.07164624
58MP0006035_abnormal_mitochondrial_morpho1.07108261
59MP0001286_abnormal_eye_development1.06784878
60MP0004185_abnormal_adipocyte_glucose1.04967393
61MP0001915_intracranial_hemorrhage1.04162338
62MP0001145_abnormal_male_reproductive1.01712645
63MP0005397_hematopoietic_system_phenotyp1.01195125
64MP0001545_abnormal_hematopoietic_system1.01195125
65MP0004133_heterotaxia1.00315401
66MP0005187_abnormal_penis_morphology1.00257060
67MP0008438_abnormal_cutaneous_collagen0.97754725
68MP0005501_abnormal_skin_physiology0.96706904
69MP0002796_impaired_skin_barrier0.95420250
70MP0001293_anophthalmia0.94382876
71MP0005023_abnormal_wound_healing0.88674149
72MP0000653_abnormal_sex_gland0.87459383
73MP0003315_abnormal_perineum_morphology0.87414310
74MP0005248_abnormal_Harderian_gland0.86619058
75MP0001929_abnormal_gametogenesis0.86172507
76MP0000579_abnormal_nail_morphology0.84353463
77MP0001188_hyperpigmentation0.84260250
78MP0003806_abnormal_nucleotide_metabolis0.83783557
79MP0003941_abnormal_skin_development0.81863573
80MP0002233_abnormal_nose_morphology0.81773946
81MP0000703_abnormal_thymus_morphology0.81653575
82MP0001346_abnormal_lacrimal_gland0.81325291
83MP0003566_abnormal_cell_adhesion0.78619885
84MP0003115_abnormal_respiratory_system0.78268650
85MP0005623_abnormal_meninges_morphology0.77756216
86MP0000733_abnormal_muscle_development0.76522394
87MP0005384_cellular_phenotype0.76207895
88MP0000358_abnormal_cell_content/0.75865385
89MP0001529_abnormal_vocalization0.74812398
90MP0001119_abnormal_female_reproductive0.73998760
91MP0000647_abnormal_sebaceous_gland0.73824639
92MP0009278_abnormal_bone_marrow0.73237320
93MP0003221_abnormal_cardiomyocyte_apopto0.73236996
94MP0002160_abnormal_reproductive_system0.72872684
95MP0000569_abnormal_digit_pigmentation0.72360973
96MP0004264_abnormal_extraembryonic_tissu0.71919056
97MP0003943_abnormal_hepatobiliary_system0.71569726
98MP0002095_abnormal_skin_pigmentation0.69059647
99MP0001243_abnormal_dermal_layer0.68838447
100MP0005389_reproductive_system_phenotype0.68469437
101MP0005621_abnormal_cell_physiology0.67025975
102MP0001727_abnormal_embryo_implantation0.66635028
103MP0000762_abnormal_tongue_morphology0.64445656
104MP0002092_abnormal_eye_morphology0.64208969
105MP0003699_abnormal_female_reproductive0.63665898
106MP0001919_abnormal_reproductive_system0.62630173
107MP0002722_abnormal_immune_system0.62608736
108MP0003755_abnormal_palate_morphology0.62233287
109MP0000566_synostosis0.62229171
110MP0000432_abnormal_head_morphology0.60662069
111MP0005408_hypopigmentation0.59412483
112MP0002398_abnormal_bone_marrow0.58823770
113MP0002925_abnormal_cardiovascular_devel0.56984396
114MP0004233_abnormal_muscle_weight0.56973850
115MP0003861_abnormal_nervous_system0.56394930
116MP0005395_other_phenotype0.56287788
117MP0002114_abnormal_axial_skeleton0.56230751
118MP0000858_altered_metastatic_potential0.56075511
119MP0002127_abnormal_cardiovascular_syste0.55947923
120MP0002938_white_spotting0.55850986
121MP0000689_abnormal_spleen_morphology0.55576178
122MP0003942_abnormal_urinary_system0.55371570
123MP0003787_abnormal_imprinting0.55168398
124MP0003385_abnormal_body_wall0.55122915
125MP0003935_abnormal_craniofacial_develop0.54529737
126MP0002075_abnormal_coat/hair_pigmentati0.53267947
127MP0009333_abnormal_splenocyte_physiolog0.53093065

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.83614073
2Birth length less than 3rd percentile (HP:0003561)4.38118798
3Volvulus (HP:0002580)4.29094018
4Medulloblastoma (HP:0002885)4.12884604
5Chromsome breakage (HP:0040012)3.78113908
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45860823
7Cortical dysplasia (HP:0002539)3.41031242
8Breast hypoplasia (HP:0003187)3.37134545
9High anterior hairline (HP:0009890)3.34183983
10Astrocytoma (HP:0009592)3.28429147
11Abnormality of the astrocytes (HP:0100707)3.28429147
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22352061
13Selective tooth agenesis (HP:0001592)3.20325616
14Increased nuchal translucency (HP:0010880)3.16585898
15Reticulocytopenia (HP:0001896)3.13806484
16Agnosia (HP:0010524)3.11599068
17Abnormality of chromosome stability (HP:0003220)3.07270245
18Ependymoma (HP:0002888)3.05371961
19Glioma (HP:0009733)3.01445737
20Patellar aplasia (HP:0006443)2.97968661
21Microvesicular hepatic steatosis (HP:0001414)2.86708980
22Neoplasm of the oral cavity (HP:0100649)2.82368107
23Multiple enchondromatosis (HP:0005701)2.81482152
24Abnormal umbilical cord blood vessels (HP:0011403)2.79534477
25Single umbilical artery (HP:0001195)2.79534477
26Abnormality of the fetal cardiovascular system (HP:0010948)2.79534477
27Aplasia/Hypoplasia of the patella (HP:0006498)2.76475632
28Meckel diverticulum (HP:0002245)2.75503127
29Rhabdomyosarcoma (HP:0002859)2.69992892
30Oral leukoplakia (HP:0002745)2.67186951
31Proximal placement of thumb (HP:0009623)2.65197630
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.64505765
33Abnormality of the ileum (HP:0001549)2.63127576
34Neoplasm of the adrenal cortex (HP:0100641)2.60877554
35Impulsivity (HP:0100710)2.59263916
36Deviation of the thumb (HP:0009603)2.57548733
37Abnormality of the anterior horn cell (HP:0006802)2.55347209
38Degeneration of anterior horn cells (HP:0002398)2.55347209
39Ectopic kidney (HP:0000086)2.54667768
40Abnormality of the preputium (HP:0100587)2.54580998
41Short 4th metacarpal (HP:0010044)2.51121053
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51121053
43Small intestinal stenosis (HP:0012848)2.48907606
44Duodenal stenosis (HP:0100867)2.48907606
45Absent radius (HP:0003974)2.47656281
46Abnormality of the labia minora (HP:0012880)2.46207879
47Absent thumb (HP:0009777)2.43244954
48Abnormality of glycolysis (HP:0004366)2.42880482
49Myelodysplasia (HP:0002863)2.38808176
50Abnormality of the umbilical cord (HP:0010881)2.36718838
51Progressive external ophthalmoplegia (HP:0000590)2.32044459
52Atresia of the external auditory canal (HP:0000413)2.30109380
53Abnormal lung lobation (HP:0002101)2.29973377
54Aplasia involving forearm bones (HP:0009822)2.28981592
55Absent forearm bone (HP:0003953)2.28981592
56Spastic diplegia (HP:0001264)2.26795801
57Increased serum pyruvate (HP:0003542)2.25679396
58High pitched voice (HP:0001620)2.24221490
59Choanal atresia (HP:0000453)2.22468020
60Subacute progressive viral hepatitis (HP:0006572)2.21691410
61Sloping forehead (HP:0000340)2.21625430
62Neoplasm of the colon (HP:0100273)2.20488190
63Abnormality of cells of the erythroid lineage (HP:0012130)2.20291213
64Fibroma (HP:0010614)2.18721103
65Fibrous tissue neoplasm (HP:0012316)2.18228761
66Horseshoe kidney (HP:0000085)2.16911569
67Supernumerary bones of the axial skeleton (HP:0009144)2.16008589
68Abnormal number of erythroid precursors (HP:0012131)2.15324225
69Abnormality of the carotid arteries (HP:0005344)2.10312295
70Overlapping toe (HP:0001845)2.10239056
71Renal duplication (HP:0000075)2.09917940
72Abnormality of methionine metabolism (HP:0010901)2.06043785
73Neoplasm of striated muscle (HP:0009728)2.05801880
74Facial hemangioma (HP:0000329)2.05453551
75Deep philtrum (HP:0002002)2.05037989
76Aplasia/Hypoplasia of the sternum (HP:0006714)2.02752948
77Embryonal neoplasm (HP:0002898)2.02384945
78Abnormality of the duodenum (HP:0002246)2.02345673
79Supernumerary ribs (HP:0005815)2.02239416
80Abnormal number of incisors (HP:0011064)2.02217611
81Neoplasm of the pancreas (HP:0002894)2.00131818
82Sandal gap (HP:0001852)2.00025642
83IgM deficiency (HP:0002850)1.99478486
84Pancreatic islet-cell hyperplasia (HP:0004510)1.99315034
85Missing ribs (HP:0000921)1.98146690
86Progressive muscle weakness (HP:0003323)1.96761936
87Carpal bone hypoplasia (HP:0001498)1.96576171
88Rough bone trabeculation (HP:0100670)1.96437375
89Prominent nose (HP:0000448)1.95112044
90Cafe-au-lait spot (HP:0000957)1.94635434
91Hypochromic microcytic anemia (HP:0004840)1.94455228
92Clubbing of toes (HP:0100760)1.93947695
93Arteriovenous malformation (HP:0100026)1.92942901
94Tracheoesophageal fistula (HP:0002575)1.91489398
95Abnormality of cochlea (HP:0000375)1.91450221
96Nephroblastoma (Wilms tumor) (HP:0002667)1.90757673
97Gastrointestinal carcinoma (HP:0002672)1.90658500
98Malignant gastrointestinal tract tumors (HP:0006749)1.90658500
99Slender long bone (HP:0003100)1.90088171
100Triphalangeal thumb (HP:0001199)1.88929209
101Protrusio acetabuli (HP:0003179)1.87597656
102Curly hair (HP:0002212)1.87574630
103Microglossia (HP:0000171)1.87103326
104Intestinal polyposis (HP:0200008)1.86056870
105Intestinal polyp (HP:0005266)1.85805151
106Duplication of thumb phalanx (HP:0009942)1.85572817
107Supernumerary spleens (HP:0009799)1.85566444
108Facial cleft (HP:0002006)1.84117689
109Basal cell carcinoma (HP:0002671)1.83329591
110Embryonal renal neoplasm (HP:0011794)1.82521677
11111 pairs of ribs (HP:0000878)1.81230244
112Respiratory difficulties (HP:0002880)1.80840309
113Bone marrow hypocellularity (HP:0005528)1.79850977
114Back pain (HP:0003418)1.79175458
115Premature graying of hair (HP:0002216)1.78176965
116Macrocytic anemia (HP:0001972)1.77595497
117Short thumb (HP:0009778)1.76139399
118Hypoplastic pelvis (HP:0008839)1.75050313
119Squamous cell carcinoma (HP:0002860)1.73229818
120Abnormality of abdominal situs (HP:0011620)1.72408752
121Abdominal situs inversus (HP:0003363)1.72408752
122Aplastic anemia (HP:0001915)1.71803610
123Short middle phalanx of the 5th finger (HP:0004220)1.71395670
124Ovarian neoplasm (HP:0100615)1.69469856
125Abnormality of chromosome segregation (HP:0002916)1.68773452
126Megaloblastic anemia (HP:0001889)1.68155334
127Ankyloglossia (HP:0010296)1.67829490
128Secondary amenorrhea (HP:0000869)1.66909827
129Uterine neoplasm (HP:0010784)1.65818249
130Leiomyosarcoma (HP:0100243)1.61446624
131Uterine leiomyosarcoma (HP:0002891)1.61446624
132Neoplasm of the small intestine (HP:0100833)1.61088383
133Abnormal foot bone ossification (HP:0010675)1.60098283
134Neuroblastic tumors (HP:0004376)1.59944922
135Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.59944922
136Neuroblastoma (HP:0003006)1.59944922
137Primitive neuroectodermal tumor (HP:0030065)1.59944922
138Asymmetry of the thorax (HP:0001555)1.58378283
139Abnormalities of placenta or umbilical cord (HP:0001194)1.57895933
140Breast carcinoma (HP:0003002)1.56887963
141Postnatal microcephaly (HP:0005484)1.56119328
142Premature ovarian failure (HP:0008209)1.55888553
143Biliary tract neoplasm (HP:0100574)1.54543525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.49864386
2BUB14.12516369
3WEE14.04362939
4NEK23.27664774
5PLK43.21523908
6ICK2.99901873
7NEK12.90114581
8TTK2.90037956
9ACVR1B2.46504645
10EIF2AK12.39788237
11PLK12.17483716
12SRPK12.07923398
13BRSK21.95329946
14CDK71.89413326
15NME21.85770612
16MKNK11.83854486
17LATS11.82169894
18TLK11.78805751
19TESK21.78719880
20AURKB1.77652854
21PASK1.72488347
22PLK31.66791143
23TAF11.65473750
24BRSK11.61726969
25ATR1.58993188
26VRK21.55300508
27CDK121.44367583
28RPS6KB21.41265875
29MAP3K81.40701331
30PKN21.39587977
31CHEK21.38861915
32VRK11.31614773
33CDK41.31265798
34MST41.31214119
35TSSK61.28800076
36SMG11.28384474
37ZAK1.27889931
38MKNK21.25049390
39AURKA1.24250505
40CHEK11.23289239
41TGFBR11.21745653
42SCYL21.19586611
43DYRK31.19508314
44STK101.19480172
45EPHA21.19451011
46STK41.18973093
47EEF2K1.18053984
48CCNB11.16970919
49EIF2AK31.12451480
50RPS6KA41.11208284
51TRIM281.09405603
52PAK40.97705506
53STK30.96706531
54ATM0.94808646
55CSNK1G30.93767100
56CDK20.93736722
57MST1R0.92511452
58PIM10.92348946
59CSNK1A1L0.91480834
60CDK60.87996736
61ALK0.83345280
62MELK0.80385065
63ERBB40.79679742
64STK160.79246176
65MAP3K100.78731585
66LATS20.71536453
67CDK10.71409823
68PNCK0.71142855
69CSNK1G10.70470816
70GRK60.66555408
71TESK10.65668238
72TRIB30.65563492
73MET0.65190165
74TTN0.64633774
75PDK20.64500998
76CLK10.64440570
77BRD40.63592768
78MTOR0.62232377
79TNIK0.56894342
80PBK0.56314531
81BCR0.54965097
82CSNK2A10.53893933
83NME10.53298955
84CSNK2A20.51715550
85PAK10.51661063
86LRRK20.48292344
87FLT30.48185549
88CDK80.45878374
89AKT20.45819557
90ERBB30.45018489
91EIF2AK20.44180515
92YES10.42585123
93CSNK1G20.40990374
94CSNK1E0.40706355
95NUAK10.40684768
96PAK20.40538418
97CDK180.40287470
98FGFR10.38750885
99PRKDC0.38128849
100PTK60.37888227
101CDK150.37588625
102PIM20.36816507
103STK240.36431857
104CDK11A0.35549794
105MAP2K30.35034835
106CSNK1D0.34645449
107MAP3K90.32941648
108CDK30.32468581
109CAMK1G0.32292483
110CDK140.32023893
111RAF10.30842101
112CDK90.29828632
113RPS6KA50.29117296
114TAOK20.28550330
115LIMK10.28441405
116MAPK140.27450990
117NEK90.27174277
118CAMK1D0.26731586
119STK38L0.26628808
120WNK30.25458322
121BRAF0.25327489
122BTK0.23688606
123PDGFRA0.23384009
124PRKCI0.23369797
125RPS6KB10.22920332
126PLK20.21005284
127AKT10.18660717
128GSK3B0.17800822

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.79132219
2Mismatch repair_Homo sapiens_hsa034304.59428420
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.53893600
4Base excision repair_Homo sapiens_hsa034103.48633495
5Cell cycle_Homo sapiens_hsa041103.22174091
6Homologous recombination_Homo sapiens_hsa034403.17050073
7Spliceosome_Homo sapiens_hsa030403.15165270
8* RNA transport_Homo sapiens_hsa030133.13512982
9One carbon pool by folate_Homo sapiens_hsa006703.01445722
10Nucleotide excision repair_Homo sapiens_hsa034202.83620014
11RNA polymerase_Homo sapiens_hsa030202.51256877
12Fanconi anemia pathway_Homo sapiens_hsa034602.47364433
13Ribosome_Homo sapiens_hsa030102.46415843
14Pyrimidine metabolism_Homo sapiens_hsa002402.23733161
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23471899
16Proteasome_Homo sapiens_hsa030502.14984188
17RNA degradation_Homo sapiens_hsa030182.01812019
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95375751
19mRNA surveillance pathway_Homo sapiens_hsa030151.90362522
20Non-homologous end-joining_Homo sapiens_hsa034501.87044626
21p53 signaling pathway_Homo sapiens_hsa041151.65097018
22Systemic lupus erythematosus_Homo sapiens_hsa053221.61139936
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59852406
24Basal transcription factors_Homo sapiens_hsa030221.58557890
25Steroid biosynthesis_Homo sapiens_hsa001001.40095668
26Pyruvate metabolism_Homo sapiens_hsa006201.39052041
27Oocyte meiosis_Homo sapiens_hsa041141.25703080
28Protein export_Homo sapiens_hsa030601.13553348
29MicroRNAs in cancer_Homo sapiens_hsa052061.11404742
30Purine metabolism_Homo sapiens_hsa002301.08503756
31Epstein-Barr virus infection_Homo sapiens_hsa051691.07891490
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07553900
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07503546
34Viral carcinogenesis_Homo sapiens_hsa052031.06686162
35Propanoate metabolism_Homo sapiens_hsa006401.02682405
36Biosynthesis of amino acids_Homo sapiens_hsa012300.96636565
37Basal cell carcinoma_Homo sapiens_hsa052170.93042288
38Fatty acid elongation_Homo sapiens_hsa000620.87737776
39HTLV-I infection_Homo sapiens_hsa051660.85236888
40Herpes simplex infection_Homo sapiens_hsa051680.82699866
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81963166
42Selenocompound metabolism_Homo sapiens_hsa004500.81495180
43Small cell lung cancer_Homo sapiens_hsa052220.80167081
44Alcoholism_Homo sapiens_hsa050340.79573631
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.76847714
46Colorectal cancer_Homo sapiens_hsa052100.75197266
47Antigen processing and presentation_Homo sapiens_hsa046120.72758912
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72512063
49Endometrial cancer_Homo sapiens_hsa052130.71902835
50Hippo signaling pathway_Homo sapiens_hsa043900.71389497
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.70506860
52Pentose phosphate pathway_Homo sapiens_hsa000300.70429995
53N-Glycan biosynthesis_Homo sapiens_hsa005100.68643537
54Chronic myeloid leukemia_Homo sapiens_hsa052200.66690090
55Vitamin B6 metabolism_Homo sapiens_hsa007500.66526166
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65259703
57Folate biosynthesis_Homo sapiens_hsa007900.60896307
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60412138
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58151782
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57635417
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56676385
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56041113
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55800315
64Fatty acid metabolism_Homo sapiens_hsa012120.55641107
65Thyroid cancer_Homo sapiens_hsa052160.53899236
66TGF-beta signaling pathway_Homo sapiens_hsa043500.53613436
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53577937
68Non-small cell lung cancer_Homo sapiens_hsa052230.49784204
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.48695321
70Viral myocarditis_Homo sapiens_hsa054160.46858397
71Acute myeloid leukemia_Homo sapiens_hsa052210.45782124
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45338549
73Carbon metabolism_Homo sapiens_hsa012000.44970087
74Hedgehog signaling pathway_Homo sapiens_hsa043400.44815432
75Apoptosis_Homo sapiens_hsa042100.44218051
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43531555
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42519890
78Pathways in cancer_Homo sapiens_hsa052000.42328441
79Adherens junction_Homo sapiens_hsa045200.41342947
80Prostate cancer_Homo sapiens_hsa052150.40698817
81Glutathione metabolism_Homo sapiens_hsa004800.40018757
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39613347
83Lysine degradation_Homo sapiens_hsa003100.39208095
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37707724
85Hepatitis B_Homo sapiens_hsa051610.37566984
86Galactose metabolism_Homo sapiens_hsa000520.37423752
87Huntingtons disease_Homo sapiens_hsa050160.37089354
88Metabolic pathways_Homo sapiens_hsa011000.35495028
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34555216
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.34181501
91Bladder cancer_Homo sapiens_hsa052190.33520923
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33041347
93Proteoglycans in cancer_Homo sapiens_hsa052050.32839739
94Arginine and proline metabolism_Homo sapiens_hsa003300.31806118
95Arginine biosynthesis_Homo sapiens_hsa002200.31352363
96Legionellosis_Homo sapiens_hsa051340.29548724
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26670638
98mTOR signaling pathway_Homo sapiens_hsa041500.26017661
99Fatty acid biosynthesis_Homo sapiens_hsa000610.25405875
100Pancreatic cancer_Homo sapiens_hsa052120.24574214
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23419009
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.22571985
103HIF-1 signaling pathway_Homo sapiens_hsa040660.22233961
104Wnt signaling pathway_Homo sapiens_hsa043100.21932365
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21671937
106Notch signaling pathway_Homo sapiens_hsa043300.21273958
107Dorso-ventral axis formation_Homo sapiens_hsa043200.20984360
108Sulfur relay system_Homo sapiens_hsa041220.19991225
109Vitamin digestion and absorption_Homo sapiens_hsa049770.19909473
110Melanoma_Homo sapiens_hsa052180.19413342
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19395027
112Tight junction_Homo sapiens_hsa045300.19249275
113Glioma_Homo sapiens_hsa052140.19209887
114Shigellosis_Homo sapiens_hsa051310.19167572
115FoxO signaling pathway_Homo sapiens_hsa040680.18428251
116Parkinsons disease_Homo sapiens_hsa050120.18224693
117Renin-angiotensin system_Homo sapiens_hsa046140.17209500
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15387166
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14998844
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14542794
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13416393
122Fructose and mannose metabolism_Homo sapiens_hsa000510.13391471
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12765497
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.11867512
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11860659
126B cell receptor signaling pathway_Homo sapiens_hsa046620.11449590
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.11351451
128Focal adhesion_Homo sapiens_hsa045100.09540970

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