NDC80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.99909246
2mitotic metaphase plate congression (GO:0007080)5.42931251
3kinetochore organization (GO:0051383)5.35326832
4mitotic chromosome condensation (GO:0007076)5.23842302
5protein localization to chromosome, centromeric region (GO:0071459)5.16208313
6CENP-A containing nucleosome assembly (GO:0034080)5.12615679
7chromatin remodeling at centromere (GO:0031055)5.04976899
8* mitotic sister chromatid segregation (GO:0000070)4.94800819
9metaphase plate congression (GO:0051310)4.90274307
10DNA strand elongation involved in DNA replication (GO:0006271)4.87666797
11* attachment of spindle microtubules to kinetochore (GO:0008608)4.85402242
12DNA unwinding involved in DNA replication (GO:0006268)4.85290599
13* sister chromatid segregation (GO:0000819)4.78767824
14DNA replication initiation (GO:0006270)4.68152659
15regulation of spindle organization (GO:0090224)4.66492641
16DNA replication-independent nucleosome organization (GO:0034724)4.64204139
17DNA replication-independent nucleosome assembly (GO:0006336)4.64204139
18DNA strand elongation (GO:0022616)4.61824263
19kinetochore assembly (GO:0051382)4.56780917
20telomere maintenance via semi-conservative replication (GO:0032201)4.56404840
21DNA replication-dependent nucleosome assembly (GO:0006335)4.53701880
22DNA replication-dependent nucleosome organization (GO:0034723)4.53701880
23establishment of chromosome localization (GO:0051303)4.52592699
24DNA replication checkpoint (GO:0000076)4.48211029
25nuclear pore organization (GO:0006999)4.47735308
26meiotic chromosome segregation (GO:0045132)4.43997057
27mitotic recombination (GO:0006312)4.43907166
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.42580755
29telomere maintenance via recombination (GO:0000722)4.37477764
30histone exchange (GO:0043486)4.36246719
31nuclear pore complex assembly (GO:0051292)4.35419152
32mitotic nuclear envelope disassembly (GO:0007077)4.31078286
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.30677016
34microtubule polymerization or depolymerization (GO:0031109)4.08268621
35regulation of chromosome segregation (GO:0051983)4.06882715
36protein localization to chromosome (GO:0034502)4.06647977
37positive regulation of chromosome segregation (GO:0051984)4.05853361
38spindle checkpoint (GO:0031577)4.04499310
39regulation of sister chromatid cohesion (GO:0007063)4.04048226
40centriole replication (GO:0007099)4.02405092
41membrane disassembly (GO:0030397)4.00589194
42nuclear envelope disassembly (GO:0051081)4.00589194
43regulation of mitotic spindle organization (GO:0060236)3.99863998
44regulation of mitotic metaphase/anaphase transition (GO:0030071)3.91274879
45positive regulation of mitotic sister chromatid separation (GO:1901970)3.89780107
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.89780107
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.89780107
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88384057
49negative regulation of chromosome segregation (GO:0051985)3.86496200
50regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.85664156
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.84901341
52negative regulation of sister chromatid segregation (GO:0033046)3.84901341
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.84901341
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.84901341
55resolution of meiotic recombination intermediates (GO:0000712)3.84401375
56* chromosome segregation (GO:0007059)3.83822627
57spindle assembly checkpoint (GO:0071173)3.81309526
58mitotic sister chromatid cohesion (GO:0007064)3.80358785
59telomere maintenance via telomere lengthening (GO:0010833)3.79228462
60negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.77827862
61regulation of sister chromatid segregation (GO:0033045)3.71529364
62regulation of mitotic sister chromatid separation (GO:0010965)3.71529364
63regulation of mitotic sister chromatid segregation (GO:0033047)3.71529364
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.71011810
65chromatin assembly or disassembly (GO:0006333)3.70743381
66mitotic spindle assembly checkpoint (GO:0007094)3.66600602
67regulation of centrosome cycle (GO:0046605)3.64474778
68mitotic spindle checkpoint (GO:0071174)3.62523286
69replication fork processing (GO:0031297)3.60077760
70synapsis (GO:0007129)3.57057220
71DNA double-strand break processing (GO:0000729)3.56597287
72formation of translation preinitiation complex (GO:0001731)3.56071856
73chromosome condensation (GO:0030261)3.53782599
74proteasome assembly (GO:0043248)3.53293593
75pore complex assembly (GO:0046931)3.52011369
76protein K6-linked ubiquitination (GO:0085020)3.48887757
77mitotic G2/M transition checkpoint (GO:0044818)3.47245661
78DNA topological change (GO:0006265)3.44149710
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44090495
80establishment of integrated proviral latency (GO:0075713)3.43116771
81regulation of DNA endoreduplication (GO:0032875)3.42827184
82nucleobase biosynthetic process (GO:0046112)3.41758508
83viral mRNA export from host cell nucleus (GO:0046784)3.41401937
84regulation of centriole replication (GO:0046599)3.40988419
85ATP-dependent chromatin remodeling (GO:0043044)3.38732374
86DNA packaging (GO:0006323)3.33297878
87purine nucleobase biosynthetic process (GO:0009113)3.31886876
88microtubule depolymerization (GO:0007019)3.30465705
89negative regulation of cell division (GO:0051782)3.29061520
90histone-serine phosphorylation (GO:0035404)3.26678633
91regulation of double-strand break repair via homologous recombination (GO:0010569)3.26221044
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23241649
93DNA geometric change (GO:0032392)3.22735244
94* mitotic cell cycle (GO:0000278)3.22359101
95DNA duplex unwinding (GO:0032508)3.22024877
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.21565684
97regulation of nuclear cell cycle DNA replication (GO:0033262)3.20152620
98negative regulation of nuclear division (GO:0051784)3.17940697
99nuclear envelope organization (GO:0006998)3.16347447
100deoxyribonucleotide biosynthetic process (GO:0009263)3.13234195
101DNA conformation change (GO:0071103)3.13226920
102DNA strand renaturation (GO:0000733)3.12627463
103centrosome organization (GO:0051297)3.12289411
104* chromosome organization (GO:0051276)3.11532405
105negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.10421351
106DNA ligation (GO:0006266)3.09878577
107telomere maintenance (GO:0000723)3.09637739
108* mitotic nuclear division (GO:0007067)3.08453309
109telomere organization (GO:0032200)3.07835917
110* mitotic spindle organization (GO:0007052)3.06693949
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04058261
112negative regulation of mitosis (GO:0045839)3.03636992
113IMP biosynthetic process (GO:0006188)3.03562070
114translesion synthesis (GO:0019985)3.03211221
115somatic hypermutation of immunoglobulin genes (GO:0016446)3.03141702
116somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03141702
117ribosomal small subunit assembly (GO:0000028)2.98543665
118negative regulation of DNA-dependent DNA replication (GO:2000104)2.97786517
119maturation of SSU-rRNA (GO:0030490)2.97446832
120folic acid-containing compound biosynthetic process (GO:0009396)2.95378254
121ribosome assembly (GO:0042255)2.92741013
122regulation of centrosome duplication (GO:0010824)2.92233312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.68487837
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.82123783
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.21876106
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.71683671
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13538452
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10576969
7* AR_21909140_ChIP-Seq_LNCAP_Human2.87987960
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63332329
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59278425
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.58549121
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52600130
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47957720
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.45779268
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39125986
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34834670
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31596438
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.29013128
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.27068426
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.27017025
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23581393
21* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17402381
22* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14220094
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11475683
24XRN2_22483619_ChIP-Seq_HELA_Human2.09496494
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08812286
26E2F7_22180533_ChIP-Seq_HELA_Human10.5191080
27VDR_23849224_ChIP-Seq_CD4+_Human1.99166888
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83167440
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81417861
30FOXP3_21729870_ChIP-Seq_TREG_Human1.81395598
31* DCP1A_22483619_ChIP-Seq_HELA_Human1.79149687
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72896746
33ELK1_19687146_ChIP-ChIP_HELA_Human1.71502001
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68436788
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67201752
36TTF2_22483619_ChIP-Seq_HELA_Human1.67116642
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59438970
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57864239
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55717009
40GABP_19822575_ChIP-Seq_HepG2_Human1.54116300
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51541753
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51479261
43EWS_26573619_Chip-Seq_HEK293_Human1.50283110
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48823901
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42869678
46* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41411886
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38913162
48KDM5A_27292631_Chip-Seq_BREAST_Human1.37341549
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36106616
50CIITA_25753668_ChIP-Seq_RAJI_Human1.35949308
51MYC_22102868_ChIP-Seq_BL_Human1.32569291
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30226181
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29392346
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28304214
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26048381
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25530067
57VDR_22108803_ChIP-Seq_LS180_Human1.25340744
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24534059
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.24360968
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.18909974
61ZNF274_21170338_ChIP-Seq_K562_Hela1.17239368
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17080524
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16692676
64FUS_26573619_Chip-Seq_HEK293_Human1.13435727
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13221544
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13151968
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12260164
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11115145
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10281055
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09587189
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07532308
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.05890057
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03917617
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02170822
75STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99534117
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99519238
77SOX2_16153702_ChIP-ChIP_HESCs_Human0.98773527
78IRF1_19129219_ChIP-ChIP_H3396_Human0.97530768
79MYC_18940864_ChIP-ChIP_HL60_Human0.95671362
80TFEB_21752829_ChIP-Seq_HELA_Human0.95655388
81SRF_21415370_ChIP-Seq_HL-1_Mouse0.95635983
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94250824
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93992269
84ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92053012
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91295574
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89894308
87* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89546860
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89379584
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87955961
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87408240
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86024901
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86012509
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85319401
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.82586149
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82159229
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82032814
97SPI1_23547873_ChIP-Seq_NB4_Human0.79977242
98VDR_21846776_ChIP-Seq_THP-1_Human0.79833655
99* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79088994
100IGF1R_20145208_ChIP-Seq_DFB_Human0.77407519
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76126018
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75179949
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74569077
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73597247
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.73145340
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70106733
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69757707
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69657688
109SOX9_26525672_Chip-Seq_HEART_Mouse0.69165213
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.68660195
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.68001955
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63023885
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.62813195
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.61970756
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.58084229
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.57370034
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.56515259
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.55875692
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.54739733
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.54616394
121TAF15_26573619_Chip-Seq_HEK293_Human0.51853051
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.51780176
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.50253971

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.63650014
2MP0010094_abnormal_chromosome_stability5.20699693
3MP0003111_abnormal_nucleus_morphology4.99925878
4MP0003077_abnormal_cell_cycle4.40016938
5MP0004957_abnormal_blastocyst_morpholog4.33103561
6MP0008057_abnormal_DNA_replication4.02025863
7MP0008058_abnormal_DNA_repair3.39367035
8MP0008932_abnormal_embryonic_tissue2.85528878
9MP0008877_abnormal_DNA_methylation2.79845839
10MP0008007_abnormal_cellular_replicative2.79831058
11MP0010307_abnormal_tumor_latency2.41513543
12MP0003123_paternal_imprinting2.39784826
13MP0001730_embryonic_growth_arrest2.36257234
14MP0000350_abnormal_cell_proliferation2.25374760
15MP0002396_abnormal_hematopoietic_system2.16902300
16MP0003786_premature_aging1.95273737
17MP0010352_gastrointestinal_tract_polyps1.93939498
18MP0005380_embryogenesis_phenotype1.87563046
19MP0001672_abnormal_embryogenesis/_devel1.87563046
20MP0001697_abnormal_embryo_size1.77240699
21MP0003718_maternal_effect1.72474701
22MP0002938_white_spotting1.71869782
23MP0003984_embryonic_growth_retardation1.69446915
24MP0002088_abnormal_embryonic_growth/wei1.64925738
25MP0004808_abnormal_hematopoietic_stem1.63581679
26MP0003950_abnormal_plasma_membrane1.62401636
27MP0002085_abnormal_embryonic_tissue1.61457998
28MP0003121_genomic_imprinting1.61266866
29MP0003136_yellow_coat_color1.58812072
30MP0002080_prenatal_lethality1.56920743
31MP0005076_abnormal_cell_differentiation1.53133481
32MP0000490_abnormal_crypts_of1.51250864
33MP0004147_increased_porphyrin_level1.50268930
34MP0003890_abnormal_embryonic-extraembry1.49339280
35MP0008789_abnormal_olfactory_epithelium1.46103614
36MP0002210_abnormal_sex_determination1.44687897
37MP0003567_abnormal_fetal_cardiomyocyte1.44569020
38MP0002084_abnormal_developmental_patter1.44376863
39MP0006054_spinal_hemorrhage1.42637535
40MP0002086_abnormal_extraembryonic_tissu1.42502846
41MP0002019_abnormal_tumor_incidence1.40125014
42MP0000313_abnormal_cell_death1.38528885
43MP0004197_abnormal_fetal_growth/weight/1.37599780
44MP0000372_irregular_coat_pigmentation1.34177642
45MP0001145_abnormal_male_reproductive1.26937459
46MP0001529_abnormal_vocalization1.24357289
47MP0002234_abnormal_pharynx_morphology1.23578660
48MP0006072_abnormal_retinal_apoptosis1.20291176
49MP0009053_abnormal_anal_canal1.19842879
50MP0001929_abnormal_gametogenesis1.19670947
51MP0006035_abnormal_mitochondrial_morpho1.13736366
52MP0000653_abnormal_sex_gland1.12059161
53MP0005397_hematopoietic_system_phenotyp1.08770392
54MP0001545_abnormal_hematopoietic_system1.08770392
55MP0003806_abnormal_nucleotide_metabolis1.08226847
56MP0010030_abnormal_orbit_morphology1.07417613
57MP0001293_anophthalmia1.06626430
58MP0002697_abnormal_eye_size1.06160749
59MP0002233_abnormal_nose_morphology1.05443521
60MP0000703_abnormal_thymus_morphology1.05017364
61MP0003315_abnormal_perineum_morphology0.99868698
62MP0003705_abnormal_hypodermis_morpholog0.99299345
63MP0001119_abnormal_female_reproductive0.98295162
64MP0003937_abnormal_limbs/digits/tail_de0.94857783
65MP0002398_abnormal_bone_marrow0.94733259
66MP0009333_abnormal_splenocyte_physiolog0.94124116
67MP0009672_abnormal_birth_weight0.94069409
68MP0000647_abnormal_sebaceous_gland0.93120830
69MP0002653_abnormal_ependyma_morphology0.93046125
70MP0000537_abnormal_urethra_morphology0.92580887
71MP0005394_taste/olfaction_phenotype0.90372991
72MP0005499_abnormal_olfactory_system0.90372991
73MP0002722_abnormal_immune_system0.89155169
74MP0002111_abnormal_tail_morphology0.89088018
75MP0001346_abnormal_lacrimal_gland0.88426039
76MP0000049_abnormal_middle_ear0.88240799
77MP0006036_abnormal_mitochondrial_physio0.87047389
78MP0002163_abnormal_gland_morphology0.86743619
79MP0000733_abnormal_muscle_development0.86441222
80MP0001915_intracranial_hemorrhage0.85944473
81MP0009697_abnormal_copulation0.85009047
82MP0003755_abnormal_palate_morphology0.83595905
83MP0000566_synostosis0.82703421
84MP0000689_abnormal_spleen_morphology0.82432404
85MP0003941_abnormal_skin_development0.80381486
86MP0005023_abnormal_wound_healing0.79881852
87MP0008995_early_reproductive_senescence0.79267615
88MP0009278_abnormal_bone_marrow0.79165184
89MP0000631_abnormal_neuroendocrine_gland0.78998471
90MP0009703_decreased_birth_body0.78343279
91MP0000427_abnormal_hair_cycle0.77008092
92MP0000428_abnormal_craniofacial_morphol0.76240399
93MP0005621_abnormal_cell_physiology0.75540843
94MP0005384_cellular_phenotype0.75041717
95MP0005171_absent_coat_pigmentation0.74895588
96MP0002160_abnormal_reproductive_system0.74553317
97MP0003763_abnormal_thymus_physiology0.73871065
98MP0005408_hypopigmentation0.73791378
99MP0005391_vision/eye_phenotype0.72295187
100MP0002092_abnormal_eye_morphology0.72202786
101MP0002102_abnormal_ear_morphology0.72078380
102MP0001764_abnormal_homeostasis0.72033153
103MP0003186_abnormal_redox_activity0.71033730
104MP0002429_abnormal_blood_cell0.70333311
105MP0005395_other_phenotype0.68731778
106MP0005253_abnormal_eye_physiology0.67267028
107MP0005389_reproductive_system_phenotype0.67163450
108MP0000858_altered_metastatic_potential0.66356290
109MP0001286_abnormal_eye_development0.65110725
110MP0003566_abnormal_cell_adhesion0.63442142
111MP0003115_abnormal_respiratory_system0.62266885
112MP0001919_abnormal_reproductive_system0.62043803
113MP0003283_abnormal_digestive_organ0.60456929
114MP0003935_abnormal_craniofacial_develop0.59587731
115MP0000569_abnormal_digit_pigmentation0.59445743
116MP0003698_abnormal_male_reproductive0.59168782
117MP0003119_abnormal_digestive_system0.58919041
118MP0003385_abnormal_body_wall0.58800855
119MP0002751_abnormal_autonomic_nervous0.58410690
120MP0001849_ear_inflammation0.57603229
121MP0001727_abnormal_embryo_implantation0.57413509
122MP0002177_abnormal_outer_ear0.57405749
123MP0000358_abnormal_cell_content/0.57327162
124MP0002161_abnormal_fertility/fecundity0.57308641
125MP0003699_abnormal_female_reproductive0.56994211
126MP0006292_abnormal_olfactory_placode0.56726271
127MP0001485_abnormal_pinna_reflex0.56539342
128MP0003943_abnormal_hepatobiliary_system0.56219027
129MP0004133_heterotaxia0.55877744
130MP0000716_abnormal_immune_system0.55671115
131MP0000432_abnormal_head_morphology0.55605329
132MP0003448_altered_tumor_morphology0.52985160
133MP0002932_abnormal_joint_morphology0.52568906
134MP0000477_abnormal_intestine_morphology0.51119392
135MP0003221_abnormal_cardiomyocyte_apopto0.50994394
136MP0002925_abnormal_cardiovascular_devel0.49817685
137MP0004264_abnormal_extraembryonic_tissu0.48410911
138MP0000383_abnormal_hair_follicle0.48322252
139MP0002095_abnormal_skin_pigmentation0.47530496
140MP0003861_abnormal_nervous_system0.46895035

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.84001551
2Birth length less than 3rd percentile (HP:0003561)4.72370628
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.51242239
4Abnormality of chromosome stability (HP:0003220)3.87156351
5Impulsivity (HP:0100710)3.71075624
6Reticulocytopenia (HP:0001896)3.62526260
7Breast hypoplasia (HP:0003187)3.61442586
8Meckel diverticulum (HP:0002245)3.57162334
9Abnormality of the preputium (HP:0100587)3.40809293
10Volvulus (HP:0002580)3.39411515
11Abnormality of the ileum (HP:0001549)3.36000029
12Patellar aplasia (HP:0006443)3.35948522
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.33641135
14Duodenal stenosis (HP:0100867)3.29946111
15Small intestinal stenosis (HP:0012848)3.29946111
16Colon cancer (HP:0003003)3.29260890
17Cortical dysplasia (HP:0002539)3.26757704
18Increased nuchal translucency (HP:0010880)3.24928669
19Aplasia/Hypoplasia of the patella (HP:0006498)3.12783936
20Absent radius (HP:0003974)3.11916625
21Selective tooth agenesis (HP:0001592)2.95161032
22Carpal bone hypoplasia (HP:0001498)2.92426295
23Myelodysplasia (HP:0002863)2.92336438
24Aplasia involving forearm bones (HP:0009822)2.89686072
25Absent forearm bone (HP:0003953)2.89686072
26Medulloblastoma (HP:0002885)2.85899347
27Abnormal lung lobation (HP:0002101)2.85855551
28Abnormality of the duodenum (HP:0002246)2.72978880
29Ectopic kidney (HP:0000086)2.72601477
30Absent thumb (HP:0009777)2.72520015
31Oral leukoplakia (HP:0002745)2.70071319
3211 pairs of ribs (HP:0000878)2.67227720
33Abnormality of the anterior horn cell (HP:0006802)2.67192345
34Degeneration of anterior horn cells (HP:0002398)2.67192345
35Sloping forehead (HP:0000340)2.64490750
36Proximal placement of thumb (HP:0009623)2.56735171
37Agnosia (HP:0010524)2.56535152
38Abnormality of the labia minora (HP:0012880)2.54240608
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52941190
40Nephroblastoma (Wilms tumor) (HP:0002667)2.51642770
41Abnormality of the carotid arteries (HP:0005344)2.48277009
42Deviation of the thumb (HP:0009603)2.47874796
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47328353
44Short 4th metacarpal (HP:0010044)2.47328353
45Bone marrow hypocellularity (HP:0005528)2.45924568
46Ependymoma (HP:0002888)2.43633399
47Rhabdomyosarcoma (HP:0002859)2.41848275
48Abnormality of cells of the erythroid lineage (HP:0012130)2.38023667
49Neoplasm of the pancreas (HP:0002894)2.36361453
50Abnormality of the calcaneus (HP:0008364)2.35910029
51Abnormal number of erythroid precursors (HP:0012131)2.34444938
52Embryonal renal neoplasm (HP:0011794)2.33438496
53Overlapping toe (HP:0001845)2.32352380
54Atresia of the external auditory canal (HP:0000413)2.31011163
55Pelvic girdle muscle weakness (HP:0003749)2.27564217
56Horseshoe kidney (HP:0000085)2.27336534
57Hypoplastic pelvis (HP:0008839)2.27329283
58Facial hemangioma (HP:0000329)2.27138745
59Duplicated collecting system (HP:0000081)2.27033241
60Cafe-au-lait spot (HP:0000957)2.24940311
61Rough bone trabeculation (HP:0100670)2.22701675
62Abnormality of the renal collecting system (HP:0004742)2.21942564
63Tracheoesophageal fistula (HP:0002575)2.21194076
64Triphalangeal thumb (HP:0001199)2.20082613
65Supernumerary spleens (HP:0009799)2.18081533
66High pitched voice (HP:0001620)2.17656790
67Neoplasm of the colon (HP:0100273)2.17376784
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.15262734
69Short thumb (HP:0009778)2.14763097
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12285631
71Clubbing of toes (HP:0100760)2.10774974
72Abnormal number of incisors (HP:0011064)2.10301531
73Oligodactyly (hands) (HP:0001180)2.10062217
74Abnormality of the fingertips (HP:0001211)2.09041077
75Acute encephalopathy (HP:0006846)2.08818200
76Small hand (HP:0200055)2.08155843
77Molar tooth sign on MRI (HP:0002419)2.06341261
78Abnormality of midbrain morphology (HP:0002418)2.06341261
79Embryonal neoplasm (HP:0002898)2.06131784
80Pancreatic cysts (HP:0001737)2.05620671
81Basal cell carcinoma (HP:0002671)2.05613882
82True hermaphroditism (HP:0010459)2.03326299
83Gastrointestinal carcinoma (HP:0002672)2.02743483
84Malignant gastrointestinal tract tumors (HP:0006749)2.02743483
85Pancreatic fibrosis (HP:0100732)2.02675023
86Acute necrotizing encephalopathy (HP:0006965)2.02344925
87Aplastic anemia (HP:0001915)2.00397170
88Aplasia/Hypoplasia of the earlobes (HP:0009906)2.00004641
89Biliary tract neoplasm (HP:0100574)1.99978994
90Broad distal phalanx of finger (HP:0009836)1.99690436
91Arteriovenous malformation (HP:0100026)1.99376394
92Subacute progressive viral hepatitis (HP:0006572)1.97545298
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96798277
94Astigmatism (HP:0000483)1.94665676
95Long clavicles (HP:0000890)1.93134748
96Prominent nose (HP:0000448)1.92876464
97Premature graying of hair (HP:0002216)1.92848188
98Abnormality of the musculature of the pelvis (HP:0001469)1.89209152
99Abnormality of the hip-girdle musculature (HP:0001445)1.89209152
100Abnormal spermatogenesis (HP:0008669)1.89146681
101Oligodactyly (HP:0012165)1.87993484
102Squamous cell carcinoma (HP:0002860)1.87297124
103Holoprosencephaly (HP:0001360)1.86648010
104Oligohydramnios (HP:0001562)1.86527940
105Preaxial hand polydactyly (HP:0001177)1.84290104
106Choanal atresia (HP:0000453)1.84235709
107Ovarian neoplasm (HP:0100615)1.84151683
108Dandy-Walker malformation (HP:0001305)1.84120121
109Slender long bone (HP:0003100)1.83643525
110Calcaneovalgus deformity (HP:0001848)1.82873151
111Cellular immunodeficiency (HP:0005374)1.82444539
112Glioma (HP:0009733)1.82219702
113Abnormal mitochondria in muscle tissue (HP:0008316)1.82119166
114Ureteral duplication (HP:0000073)1.81977785
115Increased density of long bones (HP:0006392)1.81959583
116Missing ribs (HP:0000921)1.81829563
117Abnormality of DNA repair (HP:0003254)1.81484833
118Deep philtrum (HP:0002002)1.80623618
119Abnormality of cochlea (HP:0000375)1.80510270
120Diastasis recti (HP:0001540)1.79569211
121Macrocytic anemia (HP:0001972)1.78898505
122Shoulder girdle muscle weakness (HP:0003547)1.78238161
123Sandal gap (HP:0001852)1.77235710
124Abnormality of chromosome segregation (HP:0002916)1.73934123
125Hypoplasia of the pons (HP:0012110)1.73591440
126Irregular epiphyses (HP:0010582)1.73415084
127Methylmalonic acidemia (HP:0002912)1.71910412
128Abnormality of the pons (HP:0007361)1.71732686
129Abnormality of the proximal phalanges of the hand (HP:0009834)1.71113470
130Sclerocornea (HP:0000647)1.70380981
131Increased CSF lactate (HP:0002490)1.65010019
132Aganglionic megacolon (HP:0002251)1.62571846
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.60940578
134Progressive external ophthalmoplegia (HP:0000590)1.59510541
135Median cleft lip (HP:0000161)1.59475012
136Duplication of thumb phalanx (HP:0009942)1.59093906
137Postaxial foot polydactyly (HP:0001830)1.57042443
138Absent septum pellucidum (HP:0001331)1.56698923
139Progressive macrocephaly (HP:0004481)1.56223964
140Septo-optic dysplasia (HP:0100842)1.55240248
141Anencephaly (HP:0002323)1.54788290
142Urethral obstruction (HP:0000796)1.54166161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.15005415
2CDC74.99928954
3WEE14.62744497
4* NEK23.47754782
5TTK3.18860638
6PLK43.15668912
7BRSK22.77494532
8ACVR1B2.70292641
9EIF2AK12.55975246
10PLK12.43773571
11SRPK12.33502147
12CCNB12.29821782
13VRK22.08332721
14* AURKB2.07766722
15BRSK12.00692951
16PLK31.99667852
17STK41.74748090
18ATR1.71676719
19EIF2AK31.71348772
20CHEK21.69137078
21TAF11.68722043
22MKNK11.68641147
23STK101.62282421
24CDK121.59619475
25VRK11.52763760
26CDK71.51093357
27PASK1.49974966
28MAP3K81.49181701
29ZAK1.42318210
30RPS6KA41.41524034
31TSSK61.40975133
32CHEK11.37426757
33AURKA1.31532903
34TLK11.31071332
35MELK1.28394440
36DYRK31.26565904
37CDK41.24812932
38STK161.19725905
39NME21.18752126
40RPS6KB21.15637812
41TESK21.15148061
42WNK31.12788762
43TRIM281.11742934
44CLK11.09365858
45CDK61.06260090
46STK31.05347280
47ATM1.02989940
48UHMK11.02330415
49MKNK21.00666741
50PLK20.98327128
51PAK40.97586144
52BMPR1B0.93212341
53MAP4K20.92459183
54CDK20.88100969
55PIM10.87555745
56PBK0.86264536
57SCYL20.80274947
58CDK10.79715721
59EIF2AK20.78053327
60TGFBR10.75776665
61* NEK10.75256384
62BRAF0.73971331
63EEF2K0.69611072
64EPHA20.69477280
65MAPK130.63326433
66NME10.61037057
67MST40.60726810
68BRD40.58467867
69CSNK2A10.57106102
70STK38L0.54391572
71MAP4K10.54251265
72LRRK20.54173716
73RPS6KA50.54128163
74TNIK0.53524695
75MAPKAPK50.52533742
76CSNK2A20.52395467
77PAK10.51203848
78MAP3K100.49286780
79MET0.49248394
80PRKCI0.48675330
81MARK30.47620325
82LATS10.46689130
83PDK20.44621979
84BCR0.44226851
85CDK80.42849227
86CDK30.40220548
87FRK0.39592223
88DYRK20.37788125
89ALK0.37744227
90TESK10.37371393
91NEK90.35590845
92PRKDC0.34815392
93MINK10.32926160
94ERBB40.32346189
95PDK30.29453666
96PDK40.29453666
97MTOR0.29261402
98CDK140.28867901
99AKT20.28349381
100CSNK1G30.28117137
101PNCK0.27362909
102PKN20.27202563
103CSNK1D0.26515155
104MAP3K40.26419872
105MAPK140.24656602
106MST1R0.24149544
107ERBB30.24034979
108PKN10.22918770
109DAPK10.22018515
110CSNK1G20.21763118
111AKT10.21734856
112PRKCG0.21637246
113RPS6KC10.21163366
114RPS6KL10.21163366
115CHUK0.20899846
116CSNK1E0.20334871
117YES10.18716338
118TTN0.17844608
119FLT30.16877262
120KDR0.16400573
121CDK11A0.16185488
122CDK150.15787134
123RPS6KA60.15762055
124NUAK10.15560079
125RAF10.15266686
126BTK0.14964057
127CSNK1G10.14585261
128CDK180.14174706
129GSK3B0.14125610
130CSNK1A1L0.13169785

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.47521736
2Mismatch repair_Homo sapiens_hsa034304.65314616
3Cell cycle_Homo sapiens_hsa041103.52096539
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50089405
5Homologous recombination_Homo sapiens_hsa034403.48516841
6RNA transport_Homo sapiens_hsa030133.28479158
7Base excision repair_Homo sapiens_hsa034103.27014612
8Spliceosome_Homo sapiens_hsa030403.20057609
9Nucleotide excision repair_Homo sapiens_hsa034202.92046820
10Fanconi anemia pathway_Homo sapiens_hsa034602.82344627
11Proteasome_Homo sapiens_hsa030502.62241999
12One carbon pool by folate_Homo sapiens_hsa006702.56913632
13RNA polymerase_Homo sapiens_hsa030202.54298064
14Ribosome_Homo sapiens_hsa030102.36568907
15Non-homologous end-joining_Homo sapiens_hsa034502.33441006
16Pyrimidine metabolism_Homo sapiens_hsa002402.19603603
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13663201
18Basal transcription factors_Homo sapiens_hsa030222.04868175
19p53 signaling pathway_Homo sapiens_hsa041152.01058672
20mRNA surveillance pathway_Homo sapiens_hsa030151.99318485
21RNA degradation_Homo sapiens_hsa030181.93176020
22Systemic lupus erythematosus_Homo sapiens_hsa053221.75199289
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61388037
24Oocyte meiosis_Homo sapiens_hsa041141.53362871
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52916779
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33791491
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28195455
28Propanoate metabolism_Homo sapiens_hsa006401.26110397
29Parkinsons disease_Homo sapiens_hsa050121.22371087
30Epstein-Barr virus infection_Homo sapiens_hsa051691.19309404
31Viral carcinogenesis_Homo sapiens_hsa052031.18485056
32Steroid biosynthesis_Homo sapiens_hsa001001.16659364
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15811999
34Purine metabolism_Homo sapiens_hsa002301.14670184
35Oxidative phosphorylation_Homo sapiens_hsa001901.12520661
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10728981
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01994138
38Pyruvate metabolism_Homo sapiens_hsa006201.01651654
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01356728
40Vitamin B6 metabolism_Homo sapiens_hsa007500.99294040
41MicroRNAs in cancer_Homo sapiens_hsa052060.96217563
42Herpes simplex infection_Homo sapiens_hsa051680.93323285
43HTLV-I infection_Homo sapiens_hsa051660.90656511
44Antigen processing and presentation_Homo sapiens_hsa046120.90103809
45Small cell lung cancer_Homo sapiens_hsa052220.78552321
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75573096
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74918040
48Pentose phosphate pathway_Homo sapiens_hsa000300.74056238
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72618151
50Fatty acid elongation_Homo sapiens_hsa000620.71178536
51Alcoholism_Homo sapiens_hsa050340.71135211
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65865651
53Thyroid cancer_Homo sapiens_hsa052160.65796175
54Butanoate metabolism_Homo sapiens_hsa006500.63361862
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.62159637
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61241458
57Selenocompound metabolism_Homo sapiens_hsa004500.61184055
58Nitrogen metabolism_Homo sapiens_hsa009100.59360593
59Alzheimers disease_Homo sapiens_hsa050100.57244071
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54910401
61Biosynthesis of amino acids_Homo sapiens_hsa012300.54477162
62Primary immunodeficiency_Homo sapiens_hsa053400.53613844
63TGF-beta signaling pathway_Homo sapiens_hsa043500.53407455
64Colorectal cancer_Homo sapiens_hsa052100.50282748
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49209137
66Hippo signaling pathway_Homo sapiens_hsa043900.47253753
67Apoptosis_Homo sapiens_hsa042100.46984320
68Metabolic pathways_Homo sapiens_hsa011000.46592873
69Legionellosis_Homo sapiens_hsa051340.44566249
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44545920
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.42199083
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.41917211
73Hepatitis B_Homo sapiens_hsa051610.41572016
74Fatty acid metabolism_Homo sapiens_hsa012120.40667232
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40362313
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40253285
77Folate biosynthesis_Homo sapiens_hsa007900.39313128
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37774845
79Chronic myeloid leukemia_Homo sapiens_hsa052200.37282215
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36661044
81Basal cell carcinoma_Homo sapiens_hsa052170.36517315
82Viral myocarditis_Homo sapiens_hsa054160.33816990
83Measles_Homo sapiens_hsa051620.33288561
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32745809
85Phototransduction_Homo sapiens_hsa047440.32337356
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.32177958
87Prostate cancer_Homo sapiens_hsa052150.31907522
88Shigellosis_Homo sapiens_hsa051310.31501837
89Adherens junction_Homo sapiens_hsa045200.30678224
90Pathways in cancer_Homo sapiens_hsa052000.30034983
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28231545
92Glutathione metabolism_Homo sapiens_hsa004800.28090989
93Lysine degradation_Homo sapiens_hsa003100.27750489
94Pancreatic cancer_Homo sapiens_hsa052120.27167381
95Notch signaling pathway_Homo sapiens_hsa043300.26339502
96FoxO signaling pathway_Homo sapiens_hsa040680.26101356
97Hematopoietic cell lineage_Homo sapiens_hsa046400.25208150
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25132532
99HIF-1 signaling pathway_Homo sapiens_hsa040660.24168230
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.23991579
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.23488689
102mTOR signaling pathway_Homo sapiens_hsa041500.23151287
103Bladder cancer_Homo sapiens_hsa052190.22425463
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21608337
105Influenza A_Homo sapiens_hsa051640.21415654
106Fatty acid degradation_Homo sapiens_hsa000710.20530515
107Tryptophan metabolism_Homo sapiens_hsa003800.19323601
108Carbon metabolism_Homo sapiens_hsa012000.19188530
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19178127
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18883251
111Peroxisome_Homo sapiens_hsa041460.18540352
112Olfactory transduction_Homo sapiens_hsa047400.17980615
113Non-small cell lung cancer_Homo sapiens_hsa052230.17768589
114Hedgehog signaling pathway_Homo sapiens_hsa043400.17626119
115N-Glycan biosynthesis_Homo sapiens_hsa005100.17240032
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15579129
117Sulfur relay system_Homo sapiens_hsa041220.15055634
118Protein export_Homo sapiens_hsa030600.14685409
119Regulation of autophagy_Homo sapiens_hsa041400.12663256
120Proteoglycans in cancer_Homo sapiens_hsa052050.12185679
121Renin-angiotensin system_Homo sapiens_hsa046140.11699772
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11299916
123Tight junction_Homo sapiens_hsa045300.11233157
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09919348
125Caffeine metabolism_Homo sapiens_hsa002320.09680533
126Huntingtons disease_Homo sapiens_hsa050160.09490554
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07723046
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07624466
129Melanoma_Homo sapiens_hsa052180.07344511
130Wnt signaling pathway_Homo sapiens_hsa043100.06715287
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06014708
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.05957565
133B cell receptor signaling pathway_Homo sapiens_hsa046620.05262671
134Arginine and proline metabolism_Homo sapiens_hsa003300.04651638
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.04592168
136Endometrial cancer_Homo sapiens_hsa052130.03480270
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.03208252

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