NDEL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.28299842
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.57420644
3negative regulation of cell killing (GO:0031342)4.57420644
4detection of molecule of bacterial origin (GO:0032490)4.54137054
5positive regulation by symbiont of host defense response (GO:0052509)4.52031295
6modulation by symbiont of host defense response (GO:0052031)4.52031295
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.52031295
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.52031295
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.52031295
10modulation by symbiont of host immune response (GO:0052553)4.52031295
11macrophage activation involved in immune response (GO:0002281)4.06946882
12positive regulation of gamma-delta T cell activation (GO:0046645)4.01538199
13detection of external biotic stimulus (GO:0098581)4.00157634
14COPI coating of Golgi vesicle (GO:0048205)3.98383315
15Golgi transport vesicle coating (GO:0048200)3.98383315
16response to peptidoglycan (GO:0032494)3.82155951
17cellular extravasation (GO:0045123)3.80916803
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.78587517
19establishment of skin barrier (GO:0061436)3.65628760
20negative regulation of interleukin-12 production (GO:0032695)3.63818520
21regulation of T-helper 2 cell differentiation (GO:0045628)3.61901061
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58238255
23skin morphogenesis (GO:0043589)3.57682988
24regulation of water loss via skin (GO:0033561)3.57382350
25regulation of interferon-beta biosynthetic process (GO:0045357)3.49543143
26detection of biotic stimulus (GO:0009595)3.45178653
27antigen processing and presentation of endogenous antigen (GO:0019883)3.36682547
28neutrophil activation involved in immune response (GO:0002283)3.33050200
29positive regulation of vesicle fusion (GO:0031340)3.30484067
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.30366262
31regulation of B cell receptor signaling pathway (GO:0050855)3.29987487
32leukocyte aggregation (GO:0070486)3.20163872
33neutrophil mediated immunity (GO:0002446)3.19230504
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18474947
35macrophage activation (GO:0042116)3.15033140
36germinal center formation (GO:0002467)3.10278123
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.09958684
38regulation of gamma-delta T cell activation (GO:0046643)3.06524590
39negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04533383
40positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03508773
41wound healing, spreading of epidermal cells (GO:0035313)3.03458485
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01011023
43response to interleukin-15 (GO:0070672)2.99773938
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99756603
45response to host immune response (GO:0052572)2.99756603
46positive regulation of p38MAPK cascade (GO:1900745)2.99207715
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98531161
48response to host (GO:0075136)2.98531161
49response to host defenses (GO:0052200)2.98531161
50protein retention in ER lumen (GO:0006621)2.96366257
51negative regulation of T cell mediated immunity (GO:0002710)2.93760705
52lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93363678
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91076963
54plasma membrane repair (GO:0001778)2.90330752
55keratinization (GO:0031424)2.90064602
56leukocyte migration involved in inflammatory response (GO:0002523)2.89115147
57negative regulation of erythrocyte differentiation (GO:0045647)2.86872647
58microglial cell activation (GO:0001774)2.86739647
59neutrophil activation (GO:0042119)2.85610313
60negative regulation of leukocyte mediated immunity (GO:0002704)2.85221655
61hemidesmosome assembly (GO:0031581)2.78556607
62myeloid cell activation involved in immune response (GO:0002275)2.75752323
63granulocyte activation (GO:0036230)2.73769719
64positive regulation of cellular amide metabolic process (GO:0034250)2.73531379
65regulation of necroptotic process (GO:0060544)2.72219670
66negative regulation of type 2 immune response (GO:0002829)2.69539607
67type I interferon signaling pathway (GO:0060337)2.69404545
68cellular response to type I interferon (GO:0071357)2.69404545
69regulation of gamma-delta T cell differentiation (GO:0045586)2.69085052
70myeloid leukocyte mediated immunity (GO:0002444)2.67372494
71regulation of mast cell degranulation (GO:0043304)2.66847281
72response to type I interferon (GO:0034340)2.66625843
73peptide cross-linking (GO:0018149)2.66025693
74cell adhesion mediated by integrin (GO:0033627)2.64631056
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.64116685
76negative regulation of T-helper cell differentiation (GO:0045623)2.64116685
77retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62601465
78hypotonic response (GO:0006971)2.62430705
79activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.62390308
80regulation of type B pancreatic cell apoptotic process (GO:2000674)2.61595787
81regulation of macrophage cytokine production (GO:0010935)2.58403529
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57730279
83response to laminar fluid shear stress (GO:0034616)2.57155508
84keratinocyte differentiation (GO:0030216)2.56313958
85regulation of type 2 immune response (GO:0002828)2.56084390
86regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.54968199
87regulation of leukocyte degranulation (GO:0043300)2.54918722
88phospholipid scrambling (GO:0017121)2.52792646
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.51777388
90negative regulation of cytokine production involved in immune response (GO:0002719)2.51265359
91production of molecular mediator involved in inflammatory response (GO:0002532)2.49385491
92multicellular organismal water homeostasis (GO:0050891)2.48040069
93regulation of mast cell activation involved in immune response (GO:0033006)2.45435267
94cellular response to interleukin-15 (GO:0071350)2.44905435
95positive regulation of type 2 immune response (GO:0002830)2.44516550
96respiratory burst (GO:0045730)2.43370681
97B cell receptor signaling pathway (GO:0050853)2.43236033
98positive regulation of macrophage cytokine production (GO:0060907)2.42974837
99fibroblast migration (GO:0010761)2.42821503
100regulation of interleukin-12 biosynthetic process (GO:0045075)2.41789386
101wound healing, spreading of cells (GO:0044319)2.41523823
102regulation of p38MAPK cascade (GO:1900744)2.41389526
103positive regulation of nuclease activity (GO:0032075)2.40292825
104embryonic process involved in female pregnancy (GO:0060136)2.39348211
105negative regulation of toll-like receptor signaling pathway (GO:0034122)2.37891642
106negative regulation of interleukin-6 production (GO:0032715)2.37063111
107vascular endothelial growth factor signaling pathway (GO:0038084)2.36655127
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.36612690
109defense response to protozoan (GO:0042832)2.36117954
110regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.36078972
111regulation of ruffle assembly (GO:1900027)2.36048981
112regulation of integrin-mediated signaling pathway (GO:2001044)2.35851671
113regulation of transforming growth factor beta1 production (GO:0032908)2.34948884
114regulation of T cell tolerance induction (GO:0002664)2.33796811
115cellular response to vitamin D (GO:0071305)2.33595867
116protein targeting to plasma membrane (GO:0072661)2.33260030
117positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.32770582
118negative regulation of fatty acid transport (GO:2000192)2.32281283
119myeloid leukocyte activation (GO:0002274)2.32045083
120positive regulation of heat generation (GO:0031652)2.31184048
121intermediate filament organization (GO:0045109)2.30855080
122interleukin-1-mediated signaling pathway (GO:0070498)2.30022962
123cellular response to vitamin (GO:0071295)2.29131850
124negative regulation of interleukin-17 production (GO:0032700)2.29051463
125regulation of platelet aggregation (GO:0090330)2.28224139
126regulation of vitamin D biosynthetic process (GO:0060556)2.27042865
127regulation of tolerance induction (GO:0002643)2.26530464
128interferon-gamma-mediated signaling pathway (GO:0060333)2.26145673
129T-helper 1 type immune response (GO:0042088)2.25451901
130positive regulation of receptor recycling (GO:0001921)2.25418856
131immunoglobulin mediated immune response (GO:0016064)2.25225058
132endoplasmic reticulum unfolded protein response (GO:0030968)2.25191741
133response to gravity (GO:0009629)2.25090220
134negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.25063597
135regulation of regulated secretory pathway (GO:1903305)2.24331278
136epithelial cell-cell adhesion (GO:0090136)2.22404113
137macroautophagy (GO:0016236)2.20215901
138regulation of membrane protein ectodomain proteolysis (GO:0051043)2.19907205
139activation of protein kinase A activity (GO:0034199)2.19494005
140keratinocyte proliferation (GO:0043616)2.18975352
141growth hormone receptor signaling pathway (GO:0060396)2.18373789
142water homeostasis (GO:0030104)2.17503551
143negative regulation of stress fiber assembly (GO:0051497)2.16166956
144cellular response to unfolded protein (GO:0034620)2.16153775
145synaptic vesicle maturation (GO:0016188)2.15759915
146regulation of heterotypic cell-cell adhesion (GO:0034114)2.14207072
147positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.13959663
148ER-nucleus signaling pathway (GO:0006984)2.13604443
149positive regulation of chemokine biosynthetic process (GO:0045080)2.13327940
150negative regulation of glycoprotein biosynthetic process (GO:0010561)2.12687666
151regulation of fever generation (GO:0031620)2.12540732
152vesicle coating (GO:0006901)2.10598840
153apoptotic cell clearance (GO:0043277)2.09685467
154regulation of nuclease activity (GO:0032069)2.09521539
155bundle of His cell to Purkinje myocyte communication (GO:0086069)2.09203988
156response to corticosterone (GO:0051412)2.07954320
157positive regulation of hair follicle development (GO:0051798)2.07292002
158positive regulation of hair cycle (GO:0042635)2.07292002
159membrane budding (GO:0006900)2.05035162
160cellular response to topologically incorrect protein (GO:0035967)2.04650819
161response to muramyl dipeptide (GO:0032495)2.04476699
162stress fiber assembly (GO:0043149)2.03984968
163positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.03937124
164JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.03198122
165negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.02388814
166negative regulation of interleukin-8 production (GO:0032717)2.01799634
167collagen fibril organization (GO:0030199)2.01695922
168COPII vesicle coating (GO:0048208)1.99583833
169regulation of phospholipase A2 activity (GO:0032429)1.97588610
170regulation of natural killer cell differentiation (GO:0032823)1.96627269
171detection of other organism (GO:0098543)1.95709773
172regulation of early endosome to late endosome transport (GO:2000641)1.95311950
173establishment of endothelial barrier (GO:0061028)1.93314469
174gland morphogenesis (GO:0022612)1.93290481
175epidermal cell differentiation (GO:0009913)1.93261628
176endodermal cell differentiation (GO:0035987)1.91808542
177negative regulation of glycoprotein metabolic process (GO:1903019)1.91066959
178detection of bacterium (GO:0016045)1.91012104
179phagosome maturation (GO:0090382)1.90850546
180protein localization to endosome (GO:0036010)1.88732652
181sequestering of metal ion (GO:0051238)1.88727579
182positive regulation of heterotypic cell-cell adhesion (GO:0034116)1.88237462
183cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.87628277
184transferrin transport (GO:0033572)1.87379892
185cellular response to nutrient (GO:0031670)1.87267284
186hair cycle (GO:0042633)1.86137434
187molting cycle (GO:0042303)1.86137434
188vascular endothelial growth factor receptor signaling pathway (GO:0048010)1.85741622
189negative regulation of membrane potential (GO:0045837)1.85328718
190regulation of vitamin metabolic process (GO:0030656)1.85009524
191signal peptide processing (GO:0006465)1.84775969
192regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.84462577
193adhesion of symbiont to host cell (GO:0044650)1.84273739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.17759345
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.26662630
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.21074359
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79557260
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.63794871
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37363434
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.15559913
8SPI1_23127762_ChIP-Seq_K562_Human1.93054954
9VDR_24763502_ChIP-Seq_THP-1_Human1.91664150
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90881090
11* CLOCK_20551151_ChIP-Seq_293T_Human1.87742171
12BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86349408
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86072372
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82413550
15GATA2_21666600_ChIP-Seq_HMVEC_Human1.81449513
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79863982
17CJUN_26792858_Chip-Seq_BT549_Human1.79700343
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77671958
19MAF_26560356_Chip-Seq_TH1_Human1.77269036
20KDM2B_26808549_Chip-Seq_DND41_Human1.71047912
21RUNX1_22412390_ChIP-Seq_EML_Mouse1.70780075
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69792152
23SCL_19346495_ChIP-Seq_HPC-7_Human1.69059858
24VDR_21846776_ChIP-Seq_THP-1_Human1.68974513
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65942508
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65942508
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65782475
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65654932
29* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65021965
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.64781138
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.60779926
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59738118
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59738118
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59504438
35* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59491488
36* GATA1_19941827_ChIP-Seq_MEL_Mouse1.58751351
37* SOX2_20726797_ChIP-Seq_SW620_Human1.58667608
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58448114
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.56345196
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56229178
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.54259638
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51616256
43MYB_26560356_Chip-Seq_TH2_Human1.50571593
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48228686
45SPI1_23547873_ChIP-Seq_NB4_Human1.48025274
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45082632
47UTX_26944678_Chip-Seq_JUKART_Human1.44977541
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43392070
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42833262
50MYB_26560356_Chip-Seq_TH1_Human1.41740419
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38767995
52ATF3_27146783_Chip-Seq_COLON_Human1.37766813
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36733267
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35388386
55ZNF263_19887448_ChIP-Seq_K562_Human1.34239636
56JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30519536
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.27611674
58* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27193811
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27006076
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26760352
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.25815973
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25585492
63SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24459728
64* PU_27001747_Chip-Seq_BMDM_Mouse1.24148936
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23959746
66MYC_22102868_ChIP-Seq_BL_Human1.23913872
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23842551
68* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21615014
69MAF_26560356_Chip-Seq_TH2_Human1.21180767
70ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20920588
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20128801
72RXR_22108803_ChIP-Seq_LS180_Human1.19624929
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18972590
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18922813
75* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17848070
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16768936
77GATA3_27048872_Chip-Seq_THYMUS_Human1.15480978
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15434815
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15170544
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.14860060
81TP63_23658742_ChIP-Seq_EP156T_Human1.14420907
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13351135
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13097917
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12933575
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.12923388
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12266543
87* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11032085
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10795826
89KDM2B_26808549_Chip-Seq_K562_Human1.10250536
90* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09834217
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09360413
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08729919
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08492883
94TP53_18474530_ChIP-ChIP_U2OS_Human1.07627270
95RACK7_27058665_Chip-Seq_MCF-7_Human1.06042714
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05832281
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05757012
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05499794
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03881376
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02752715
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00705349
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00057430
103RUNX1_27514584_Chip-Seq_MCF-7_Human0.99564718
104* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98641962
105MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98395810
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97838665
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97287987
108LXR_22292898_ChIP-Seq_THP-1_Human0.96478372
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96112242
110SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95743751
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.95339705
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94989342
113IRF8_27001747_Chip-Seq_BMDM_Mouse0.94541506
114KLF5_25053715_ChIP-Seq_YYC3_Human0.94201133
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93598197
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92608030
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.91911563
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91555758
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91400953
120* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90144346
121IRF8_21731497_ChIP-ChIP_J774_Mouse0.89956544
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89792975
123CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89422187
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.88478144
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88208618
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88138339
127VDR_24787735_ChIP-Seq_THP-1_Human0.87945608
128GATA1_22025678_ChIP-Seq_K562_Human0.87764496
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.85779064
130AHR_22903824_ChIP-Seq_MCF-7_Human0.85026948
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84116682
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84116125
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.83060275
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.83060275
135GATA1_19941826_ChIP-Seq_K562_Human0.82974523
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81794553
137SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81437214
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80840968
139GATA2_19941826_ChIP-Seq_K562_Human0.80445640
140SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.80022635
141SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79789514
142TCF7_22412390_ChIP-Seq_EML_Mouse0.79589317
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78721167
144BRD4_25478319_ChIP-Seq_HGPS_Human0.77778002
145RUNX_20019798_ChIP-Seq_JUKART_Human0.77027966
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76776528
147IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75930771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile4.28583003
2MP0002796_impaired_skin_barrier3.64933854
3MP0010234_abnormal_vibrissa_follicle3.39827632
4MP0002877_abnormal_melanocyte_morpholog3.00084445
5MP0008260_abnormal_autophagy2.98000539
6MP0008438_abnormal_cutaneous_collagen2.74461041
7MP0003705_abnormal_hypodermis_morpholog2.73447996
8MP0004947_skin_inflammation2.63663555
9MP0002060_abnormal_skin_morphology2.57300240
10MP0000013_abnormal_adipose_tissue2.22263680
11MP0003566_abnormal_cell_adhesion2.22093137
12MP0001835_abnormal_antigen_presentation2.19857550
13MP0000685_abnormal_immune_system2.09907258
14MP0005025_abnormal_response_to2.07803825
15MP0003724_increased_susceptibility_to2.07464320
16MP0010386_abnormal_urinary_bladder2.04994735
17MP0003656_abnormal_erythrocyte_physiolo2.01244244
18MP0003300_gastrointestinal_ulcer1.95907197
19MP0003279_aneurysm1.94101536
20MP0001958_emphysema1.92290840
21MP0005387_immune_system_phenotype1.87911689
22MP0001790_abnormal_immune_system1.87911689
23MP0003941_abnormal_skin_development1.86917043
24MP0001800_abnormal_humoral_immune1.85484513
25MP0003453_abnormal_keratinocyte_physiol1.82161561
26MP0005501_abnormal_skin_physiology1.80162462
27MP0002723_abnormal_immune_serum1.77831739
28MP0006082_CNS_inflammation1.75589341
29MP0001216_abnormal_epidermal_layer1.73910819
30MP0002909_abnormal_adrenal_gland1.73243179
31MP0004858_abnormal_nervous_system1.73237319
32MP0004510_myositis1.70082775
33MP0002420_abnormal_adaptive_immunity1.68341939
34MP0002452_abnormal_antigen_presenting1.68173095
35MP0005464_abnormal_platelet_physiology1.68073275
36MP0009840_abnormal_foam_cell1.66983282
37MP0001819_abnormal_immune_cell1.66096385
38MP0008961_abnormal_basal_metabolism1.64841014
39MP0003763_abnormal_thymus_physiology1.64635853
40MP0002837_dystrophic_cardiac_calcinosis1.60641208
41MP0010771_integument_phenotype1.60588535
42MP0003436_decreased_susceptibility_to1.60529073
43MP0003195_calcinosis1.58397053
44MP0002405_respiratory_system_inflammati1.58219863
45MP0009278_abnormal_bone_marrow1.57026615
46MP0006054_spinal_hemorrhage1.56793484
47MP0002009_preneoplasia1.56264206
48MP0003303_peritoneal_inflammation1.53311472
49MP0001533_abnormal_skeleton_physiology1.52686843
50MP0000465_gastrointestinal_hemorrhage1.45717716
51MP0004883_abnormal_blood_vessel1.45289843
52MP0001545_abnormal_hematopoietic_system1.44982863
53MP0005397_hematopoietic_system_phenotyp1.44982863
54MP0008004_abnormal_stomach_pH1.43015635
55MP0002896_abnormal_bone_mineralization1.42933606
56MP0002998_abnormal_bone_remodeling1.38486388
57MP0005671_abnormal_response_to1.34401251
58MP0002295_abnormal_pulmonary_circulatio1.33666230
59MP0005058_abnormal_lysosome_morphology1.33653416
60MP0009780_abnormal_chondrocyte_physiolo1.31234972
61MP0000343_altered_response_to1.30321717
62MP0002332_abnormal_exercise_endurance1.29662635
63MP0000569_abnormal_digit_pigmentation1.26764633
64MP0010352_gastrointestinal_tract_polyps1.25554158
65MP0002398_abnormal_bone_marrow1.25034746
66MP0001542_abnormal_bone_strength1.23663433
67MP0005023_abnormal_wound_healing1.21927807
68MP0000716_abnormal_immune_system1.21085449
69MP0001243_abnormal_dermal_layer1.20987887
70MP0010368_abnormal_lymphatic_system1.20697317
71MP0009384_cardiac_valve_regurgitation1.19320119
72MP0002132_abnormal_respiratory_system1.18378127
73MP0004381_abnormal_hair_follicle1.18303143
74MP0003183_abnormal_peptide_metabolism1.17213643
75MP0005503_abnormal_tendon_morphology1.15790977
76MP0001191_abnormal_skin_condition1.15257306
77MP0009764_decreased_sensitivity_to1.14752137
78MP0005451_abnormal_body_composition1.12899265
79MP0010155_abnormal_intestine_physiology1.12742278
80MP0001851_eye_inflammation1.12509325
81MP0005167_abnormal_blood-brain_barrier1.11987507
82MP0005390_skeleton_phenotype1.08467666
83MP0005076_abnormal_cell_differentiation1.08118301
84MP0005257_abnormal_intraocular_pressure1.07854275
85MP0003828_pulmonary_edema1.07204190
86MP0008469_abnormal_protein_level1.06463268
87MP0002722_abnormal_immune_system1.05289074
88MP0003091_abnormal_cell_migration1.04006495
89MP0002933_joint_inflammation1.03892179
90MP0004272_abnormal_basement_membrane1.03082679
91MP0001765_abnormal_ion_homeostasis1.02171486
92MP0003075_altered_response_to1.01975535
93MP0002254_reproductive_system_inflammat1.01850480
94MP0009931_abnormal_skin_appearance1.01773505
95MP0003283_abnormal_digestive_organ1.01730437
96MP0002148_abnormal_hypersensitivity_rea1.00611791
97MP0003795_abnormal_bone_structure1.00445160
98MP0009333_abnormal_splenocyte_physiolog0.98638170
99MP0005084_abnormal_gallbladder_morpholo0.98380787
100MP0003221_abnormal_cardiomyocyte_apopto0.98025502
101MP0000689_abnormal_spleen_morphology0.97903841
102MP0003690_abnormal_glial_cell0.97556669
103MP0000579_abnormal_nail_morphology0.96731579
104MP0002098_abnormal_vibrissa_morphology0.96648394
105MP0003045_fibrosis0.96043989
106MP0005166_decreased_susceptibility_to0.95475551
107MP0009785_altered_susceptibility_to0.95467986
108MP0002429_abnormal_blood_cell0.95032463
109MP0002419_abnormal_innate_immunity0.94404496
110MP0004484_altered_response_of0.93923001
111MP0002693_abnormal_pancreas_physiology0.91836963
112MP0005310_abnormal_salivary_gland0.91815594
113MP0002006_tumorigenesis0.91633216
114MP0003448_altered_tumor_morphology0.91552905
115MP0003172_abnormal_lysosome_physiology0.91200820
116MP0005083_abnormal_biliary_tract0.90666409
117MP0000427_abnormal_hair_cycle0.90628393
118MP0003191_abnormal_cellular_cholesterol0.87405223
119MP0001879_abnormal_lymphatic_vessel0.87354905
120MP0001944_abnormal_pancreas_morphology0.86890018
121MP0002166_altered_tumor_susceptibility0.86305107
122MP0000249_abnormal_blood_vessel0.86293711
123MP0005000_abnormal_immune_tolerance0.85350049
124MP0003866_abnormal_defecation0.85090041
125MP0000015_abnormal_ear_pigmentation0.82881864
126MP0002735_abnormal_chemical_nociception0.82636349
127MP0000703_abnormal_thymus_morphology0.82537158
128MP0005508_abnormal_skeleton_morphology0.82527640
129MP0005388_respiratory_system_phenotype0.81242353
130MP0002133_abnormal_respiratory_system0.81242353
131MP0005164_abnormal_response_to0.80684758
132MP0001756_abnormal_urination0.80003162
133MP0003329_amyloid_beta_deposits0.79110466
134MP0000367_abnormal_coat/_hair0.78745261
135MP0008874_decreased_physiological_sensi0.77959022
136MP0000858_altered_metastatic_potential0.76855891
137MP0000767_abnormal_smooth_muscle0.76440053
138MP0002972_abnormal_cardiac_muscle0.75928020
139MP0005409_darkened_coat_color0.75884914
140MP0005165_increased_susceptibility_to0.75276160
141MP0003950_abnormal_plasma_membrane0.74779025
142MP0000003_abnormal_adipose_tissue0.74380415
143MP0001845_abnormal_inflammatory_respons0.73861837
144MP0000230_abnormal_systemic_arterial0.73406163
145MP0000377_abnormal_hair_follicle0.72883511
146MP0001853_heart_inflammation0.72701255
147MP0004782_abnormal_surfactant_physiolog0.70638722
148MP0000750_abnormal_muscle_regeneration0.69852637
149MP0005595_abnormal_vascular_smooth0.68441662
150MP0000604_amyloidosis0.67682893

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.06976468
2Recurrent bacterial skin infections (HP:0005406)4.02084500
3Orchitis (HP:0100796)4.00715187
4Protrusio acetabuli (HP:0003179)3.96439310
5Premature rupture of membranes (HP:0001788)3.92556571
6Recurrent abscess formation (HP:0002722)3.82862387
7Abnormality of macrophages (HP:0004311)3.67082295
8Retrobulbar optic neuritis (HP:0100654)3.63544933
9Optic neuritis (HP:0100653)3.63544933
10Increased cerebral lipofuscin (HP:0011813)3.62776773
11Vertebral compression fractures (HP:0002953)3.53887266
12Increased neuronal autofluorescent lipopigment (HP:0002074)3.48559974
13Right ventricular cardiomyopathy (HP:0011663)3.47453500
14Increased IgE level (HP:0003212)3.25704182
15Gastrointestinal infarctions (HP:0005244)3.23384933
16Stomatitis (HP:0010280)3.23137015
17Recurrent gram-negative bacterial infections (HP:0005420)3.12700233
18Elevated erythrocyte sedimentation rate (HP:0003565)3.11326285
19Atrophic scars (HP:0001075)3.10920383
20Gingivitis (HP:0000230)2.92948065
21Keratoconjunctivitis sicca (HP:0001097)2.92598293
22Eczematoid dermatitis (HP:0000976)2.90222724
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.89814564
24Mediastinal lymphadenopathy (HP:0100721)2.87795862
25Distal lower limb muscle weakness (HP:0009053)2.83555423
26Hypotrichosis (HP:0001006)2.81539429
27Spontaneous hematomas (HP:0007420)2.80513366
28Increased connective tissue (HP:0009025)2.79250908
29Amyloidosis (HP:0011034)2.78271058
30Urticaria (HP:0001025)2.72108200
31Gingival bleeding (HP:0000225)2.71208584
32Aortic aneurysm (HP:0004942)2.70623551
33Abnormality of the peritoneum (HP:0002585)2.66480123
34Keratoconjunctivitis (HP:0001096)2.60988665
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.58779452
36Peritonitis (HP:0002586)2.56364898
37Recurrent skin infections (HP:0001581)2.56048354
38Hypochromic microcytic anemia (HP:0004840)2.53367308
39Cellulitis (HP:0100658)2.53007791
40Episodic fever (HP:0001954)2.52655029
41Fragile skin (HP:0001030)2.51857090
42Recurrent fungal infections (HP:0002841)2.50524622
43Dilatation of the ascending aorta (HP:0005111)2.47664536
44Polycythemia (HP:0001901)2.47516385
45Dysostosis multiplex (HP:0000943)2.47455014
46Prolonged bleeding time (HP:0003010)2.43576103
47Vacuolated lymphocytes (HP:0001922)2.41447911
48Palmoplantar hyperkeratosis (HP:0000972)2.41368351
49Epistaxis (HP:0000421)2.34638514
50Natal tooth (HP:0000695)2.34453822
51Plantar hyperkeratosis (HP:0007556)2.34054950
52Ulnar claw (HP:0001178)2.32150594
53Short nail (HP:0001799)2.29215852
54Cerebral aneurysm (HP:0004944)2.29056217
55Vascular tortuosity (HP:0004948)2.27345689
56Vasculitis (HP:0002633)2.26230497
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23528723
58Pustule (HP:0200039)2.23409455
59Slow saccadic eye movements (HP:0000514)2.22408828
60Hand muscle atrophy (HP:0009130)2.21552491
61Aortic dissection (HP:0002647)2.20975116
62Spondylolisthesis (HP:0003302)2.20526162
63Tetraparesis (HP:0002273)2.19848652
64Mucopolysacchariduria (HP:0008155)2.19202832
65Urinary glycosaminoglycan excretion (HP:0003541)2.19202832
66Beaking of vertebral bodies (HP:0004568)2.17653358
67Advanced eruption of teeth (HP:0006288)2.16387763
68Pulmonary infiltrates (HP:0002113)2.15996867
69Distal upper limb amyotrophy (HP:0007149)2.14314342
70Upper limb amyotrophy (HP:0009129)2.14314342
71Meningitis (HP:0001287)2.14117205
72T lymphocytopenia (HP:0005403)2.13652434
73Abnormal delayed hypersensitivity skin test (HP:0002963)2.13426950
74Palmar hyperkeratosis (HP:0010765)2.13029953
75Obstructive lung disease (HP:0006536)2.11501232
76Chronic obstructive pulmonary disease (HP:0006510)2.11501232
77Hyporeflexia of lower limbs (HP:0002600)2.10286396
78Cervical subluxation (HP:0003308)2.10089067
79Chest pain (HP:0100749)2.09112881
80Arterial thrombosis (HP:0004420)2.09111859
81Wormian bones (HP:0002645)2.08723810
82Thick nail (HP:0001805)2.08708032
83Insulin-resistant diabetes mellitus (HP:0000831)2.08328388
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07704508
85Abnormality of polysaccharide metabolism (HP:0011012)2.07704508
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07704508
87Gangrene (HP:0100758)2.07098376
88Erythema (HP:0010783)2.06234471
89Type 1 muscle fiber predominance (HP:0003803)2.05875527
90Thin bony cortex (HP:0002753)2.04773524
91Long toe (HP:0010511)2.04632350
92Milia (HP:0001056)2.04398386
93Hypochromic anemia (HP:0001931)2.04163575
94Soft skin (HP:0000977)2.04053442
95Abnormality of T cell number (HP:0011839)2.02042799
96Difficulty climbing stairs (HP:0003551)2.01886755
97Distal lower limb amyotrophy (HP:0008944)2.01779391
98Interstitial pulmonary disease (HP:0006530)2.01098422
99Hemoptysis (HP:0002105)1.99435873
100Loss of speech (HP:0002371)1.98965775
101Abnormality of nail color (HP:0100643)1.98342909
102Bradycardia (HP:0001662)1.97815075
103Arterial tortuosity (HP:0005116)1.96769001
104Hypercortisolism (HP:0001578)1.95984121
105Glomerulopathy (HP:0100820)1.95428782
106Spinal rigidity (HP:0003306)1.95124780
107Hyperglycemia (HP:0003074)1.95017656
108Myocardial infarction (HP:0001658)1.94542559
109Abnormality of proline metabolism (HP:0010907)1.93487611
110Hydroxyprolinuria (HP:0003080)1.93487611
111Chronic mucocutaneous candidiasis (HP:0002728)1.91274191
112Recurrent cutaneous fungal infections (HP:0011370)1.91274191
113Alopecia of scalp (HP:0002293)1.90654310
114Leukocytosis (HP:0001974)1.89617595
115Axonal loss (HP:0003447)1.89053390
116Microcytic anemia (HP:0001935)1.88648012
117Acanthosis nigricans (HP:0000956)1.87650525
118Segmental peripheral demyelination/remyelination (HP:0003481)1.87480111
119Osteomyelitis (HP:0002754)1.87057687
120Facial diplegia (HP:0001349)1.85854544
121Lip pit (HP:0100267)1.85435065
122Hypergammaglobulinemia (HP:0010702)1.82997775
123Increased variability in muscle fiber diameter (HP:0003557)1.81360189
124Increased CSF protein (HP:0002922)1.81319184
125Conjunctival hamartoma (HP:0100780)1.78762223
126Curly hair (HP:0002212)1.78738750
127Ovoid vertebral bodies (HP:0003300)1.78632851
128Mildly elevated creatine phosphokinase (HP:0008180)1.77800655
129Aneurysm (HP:0002617)1.77625499
130Skin ulcer (HP:0200042)1.76798669
131Ulnar deviation of the wrist (HP:0003049)1.76174305
132Bruising susceptibility (HP:0000978)1.76137006
133Persistence of primary teeth (HP:0006335)1.75586949
134Encephalitis (HP:0002383)1.75400720
135Hematochezia (HP:0002573)1.74720505
136Joint stiffness (HP:0001387)1.74532961
137Glucose intolerance (HP:0000833)1.74202873
138Inflammation of the large intestine (HP:0002037)1.74014346
139Woolly hair (HP:0002224)1.73532539
140Abnormality of the distal phalanges of the toes (HP:0010182)1.73455400
141Abnormality of the pericardium (HP:0001697)1.73387994
142Abnormality of skeletal muscle fiber size (HP:0012084)1.72135337
143Lower limb amyotrophy (HP:0007210)1.71724040
144Abnormality of liposaccharide metabolism (HP:0010968)1.71148590
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.71148590
146Abnormality of glycolipid metabolism (HP:0010969)1.71148590
147Pulmonary embolism (HP:0002204)1.71138214
148Achilles tendon contracture (HP:0001771)1.70973838
149Ventricular tachycardia (HP:0004756)1.70177247
150Abnormal platelet volume (HP:0011876)1.69869572
151Upper limb muscle weakness (HP:0003484)1.69635694
152Recurrent viral infections (HP:0004429)1.68954752
153Subacute progressive viral hepatitis (HP:0006572)1.68935557
154Anhidrosis (HP:0000970)1.68935543
155Striae distensae (HP:0001065)1.68370511
156Gastrointestinal inflammation (HP:0004386)1.67748880
157Scapular winging (HP:0003691)1.67692624
158Coxa vara (HP:0002812)1.67094087
159Cerebral inclusion bodies (HP:0100314)1.67027533
160Hyperextensible skin (HP:0000974)1.65768607
161Sepsis (HP:0100806)1.64595587
162Onycholysis (HP:0001806)1.64511289
163Hyperparathyroidism (HP:0000843)1.63953305
164Abnormality of calcium-phosphate metabolism (HP:0100530)1.63888851
165Hoarse voice (HP:0001609)1.63704887
166Genu recurvatum (HP:0002816)1.63660134
167Visual hallucinations (HP:0002367)1.63622611
168Menorrhagia (HP:0000132)1.63083531
169Asymmetric septal hypertrophy (HP:0001670)1.62998630
170Onion bulb formation (HP:0003383)1.62292746
171Osteopenia (HP:0000938)1.61998788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK33.00550760
2ERN12.96993713
3MAP3K32.92406129
4EPHA32.85038486
5PRPF4B2.81185150
6MAP3K92.27653940
7FER2.25728595
8IRAK42.09456789
9MAP3K22.04986757
10TIE12.04907402
11CSK1.91343644
12MAP4K11.86713677
13TRIB31.77345796
14MST1R1.75985259
15MAP3K121.73971143
16GRK61.72508603
17MAP2K31.71587857
18FES1.71530470
19ERBB31.70736271
20MAP3K11.70474659
21TAOK11.68668491
22TBK11.65730687
23RIPK11.61624424
24NTRK11.55800376
25TAOK21.47806441
26TGFBR21.45519099
27RIPK41.45432674
28MST41.42288400
29CDK121.41162996
30PRKD31.41148625
31FGR1.39949258
32KSR21.39858542
33MARK21.38866125
34MAP3K141.37285282
35MAPK151.33730454
36MAP3K61.33652969
37TTN1.32876785
38WNK11.28381815
39MAP3K131.26377372
40HCK1.21717092
41LATS21.21118219
42TRPM71.20504757
43TESK11.20029211
44CAMKK21.15496791
45CDC42BPA1.15385048
46FGFR41.14263343
47MAP3K111.13279201
48DDR21.10634127
49PIM21.08669565
50MAP2K11.08527147
51MOS1.05994667
52INSRR1.05793426
53PTK21.04298854
54EPHB11.04247255
55IRAK31.02860467
56BMPR21.02744092
57RAF11.01820167
58AKT31.01176002
59PDGFRA1.00620472
60MINK10.97221308
61PDK10.97051715
62SYK0.96652098
63TXK0.96178917
64RET0.95953194
65EPHB20.95518378
66TNK20.93474672
67BTK0.93466235
68WNK40.93173131
69TAOK30.93083246
70SIK30.92562045
71PAK30.90711945
72BMX0.90143889
73SGK30.89931690
74IRAK10.88060532
75MAP2K20.85103161
76PRKD20.83362207
77JAK10.82211821
78CAMKK10.81514073
79JAK30.81143821
80ARAF0.80455886
81NTRK30.79713341
82IRAK20.77422513
83MAPK120.76430435
84FRK0.75579163
85HIPK20.74137137
86MAP2K40.74050804
87NEK90.73838328
88MAPK70.72973624
89IKBKE0.72244162
90PIK3CA0.71655650
91IKBKB0.71300170
92BRD40.71053838
93MAP3K70.70641502
94ICK0.69869397
95PRKG20.69631655
96KSR10.69517753
97LYN0.68207194
98PTK60.68013203
99MYLK0.67911346
100MARK30.67512476
101SIK20.67205222
102LCK0.66753114
103SCYL20.66605618
104MAP3K50.64773640
105FGFR30.64744086
106CHUK0.63710282
107DAPK20.63675866
108PAK60.63597105
109PRKCE0.63153717
110WNK30.61984032
111MAPKAPK50.61929008
112LIMK10.61873395
113TESK20.61767556
114STK240.61317998
115TYK20.60956645
116PIK3CG0.60809378
117PDK20.60315241
118SGK20.59768858
119YES10.59766078
120MATK0.59382375
121ZAP700.58673419
122TEC0.58516552
123LRRK20.58403649
124STK100.58030824
125DYRK1B0.54232510
126RPS6KA40.54087411
127SIK10.53925431
128KDR0.53721953
129PRKCH0.52993848
130KIT0.52538116
131GRK50.52358555
132PDPK10.49841379
133JAK20.49123604
134RPS6KA20.48684053
135PTK2B0.48627875
136STK380.46086955
137SGK4940.45971353
138SGK2230.45971353
139BLK0.45095233
140GRK70.44998768
141ABL20.44894200
142FYN0.44425604
143ITK0.42471934
144PRKD10.40427859
145PRKAA20.40296187
146MAPKAPK20.39991055
147PDGFRB0.35922306
148MAP2K60.35741737

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046621.74407884
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72977698
3Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71397162
4Lysosome_Homo sapiens_hsa041421.70681090
5Staphylococcus aureus infection_Homo sapiens_hsa051501.66757490
6Synaptic vesicle cycle_Homo sapiens_hsa047211.64218342
7Collecting duct acid secretion_Homo sapiens_hsa049661.62143034
8Rheumatoid arthritis_Homo sapiens_hsa053231.61699710
9Vibrio cholerae infection_Homo sapiens_hsa051101.60893940
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.51642112
11TNF signaling pathway_Homo sapiens_hsa046681.47299284
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45907061
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44485106
14Leishmaniasis_Homo sapiens_hsa051401.42866452
15Osteoclast differentiation_Homo sapiens_hsa043801.41385446
16Measles_Homo sapiens_hsa051621.34026660
17Non-small cell lung cancer_Homo sapiens_hsa052231.33292624
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30743745
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28406325
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25414222
21Phagosome_Homo sapiens_hsa041451.23708693
22T cell receptor signaling pathway_Homo sapiens_hsa046601.22980526
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.22827522
24Malaria_Homo sapiens_hsa051441.21473211
25Tuberculosis_Homo sapiens_hsa051521.18725636
26Olfactory transduction_Homo sapiens_hsa047401.17922122
27Prolactin signaling pathway_Homo sapiens_hsa049171.17834557
28VEGF signaling pathway_Homo sapiens_hsa043701.17731934
29Legionellosis_Homo sapiens_hsa051341.17131735
30Salmonella infection_Homo sapiens_hsa051321.16716251
31Amoebiasis_Homo sapiens_hsa051461.16363600
32Bladder cancer_Homo sapiens_hsa052191.15370437
33Pertussis_Homo sapiens_hsa051331.14695006
34Hematopoietic cell lineage_Homo sapiens_hsa046401.13807777
35Insulin secretion_Homo sapiens_hsa049111.13701647
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12695991
37GnRH signaling pathway_Homo sapiens_hsa049121.11468428
38African trypanosomiasis_Homo sapiens_hsa051431.10164800
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08092084
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07900503
41Estrogen signaling pathway_Homo sapiens_hsa049151.06944197
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06154457
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.04575513
44Type II diabetes mellitus_Homo sapiens_hsa049301.03219633
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01596133
46ECM-receptor interaction_Homo sapiens_hsa045121.01129744
47Graft-versus-host disease_Homo sapiens_hsa053321.00415833
48Insulin resistance_Homo sapiens_hsa049310.98613376
49Renal cell carcinoma_Homo sapiens_hsa052110.97992049
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97921969
51Other glycan degradation_Homo sapiens_hsa005110.97374011
52Focal adhesion_Homo sapiens_hsa045100.95773524
53Circadian rhythm_Homo sapiens_hsa047100.94776379
54Toxoplasmosis_Homo sapiens_hsa051450.94335504
55Shigellosis_Homo sapiens_hsa051310.92330983
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91076049
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90115937
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89702002
59Proteoglycans in cancer_Homo sapiens_hsa052050.89330562
60Long-term potentiation_Homo sapiens_hsa047200.89060591
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.88645962
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88550616
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.88537645
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87601642
65Glioma_Homo sapiens_hsa052140.87082018
66Sphingolipid metabolism_Homo sapiens_hsa006000.86794437
67Herpes simplex infection_Homo sapiens_hsa051680.85508624
68Platelet activation_Homo sapiens_hsa046110.85191902
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84338354
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83764035
71mTOR signaling pathway_Homo sapiens_hsa041500.83059501
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.82964495
73Allograft rejection_Homo sapiens_hsa053300.82762956
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82584659
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82003038
76Gastric acid secretion_Homo sapiens_hsa049710.81945916
77Dilated cardiomyopathy_Homo sapiens_hsa054140.81333899
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.80227792
79Oxytocin signaling pathway_Homo sapiens_hsa049210.80212555
80Endometrial cancer_Homo sapiens_hsa052130.79091344
81Endocytosis_Homo sapiens_hsa041440.78780908
82Cocaine addiction_Homo sapiens_hsa050300.77855191
83Apoptosis_Homo sapiens_hsa042100.77757884
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76675282
85Renin secretion_Homo sapiens_hsa049240.76644927
86Viral myocarditis_Homo sapiens_hsa054160.76640025
87Circadian entrainment_Homo sapiens_hsa047130.75823682
88Cholinergic synapse_Homo sapiens_hsa047250.75720768
89Inositol phosphate metabolism_Homo sapiens_hsa005620.74833427
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74333137
91Protein digestion and absorption_Homo sapiens_hsa049740.73817589
92Hepatitis C_Homo sapiens_hsa051600.73344823
93Amphetamine addiction_Homo sapiens_hsa050310.72483783
94Adherens junction_Homo sapiens_hsa045200.71458328
95Dorso-ventral axis formation_Homo sapiens_hsa043200.71249591
96Autoimmune thyroid disease_Homo sapiens_hsa053200.71153811
97Acute myeloid leukemia_Homo sapiens_hsa052210.70949073
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.70109572
99Prion diseases_Homo sapiens_hsa050200.69250174
100Choline metabolism in cancer_Homo sapiens_hsa052310.68983200
101Insulin signaling pathway_Homo sapiens_hsa049100.68714723
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.68661059
103ErbB signaling pathway_Homo sapiens_hsa040120.68601284
104Type I diabetes mellitus_Homo sapiens_hsa049400.66735733
105Complement and coagulation cascades_Homo sapiens_hsa046100.66329257
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66007427
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65754751
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64996928
109Rap1 signaling pathway_Homo sapiens_hsa040150.64910261
110Chronic myeloid leukemia_Homo sapiens_hsa052200.63398103
111Influenza A_Homo sapiens_hsa051640.63189035
112Pancreatic secretion_Homo sapiens_hsa049720.62848885
113Dopaminergic synapse_Homo sapiens_hsa047280.62777399
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62549939
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62016232
116Salivary secretion_Homo sapiens_hsa049700.61754262
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61332243
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61301200
119Prostate cancer_Homo sapiens_hsa052150.61198023
120HIF-1 signaling pathway_Homo sapiens_hsa040660.60626287
121FoxO signaling pathway_Homo sapiens_hsa040680.60470642
122Small cell lung cancer_Homo sapiens_hsa052220.58912577
123Notch signaling pathway_Homo sapiens_hsa043300.58392011
124MAPK signaling pathway_Homo sapiens_hsa040100.58158459
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56904669
126Chemokine signaling pathway_Homo sapiens_hsa040620.56655554
127Hepatitis B_Homo sapiens_hsa051610.56569990
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56333435
129Primary immunodeficiency_Homo sapiens_hsa053400.55374040
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.55290761
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55165238
132Pancreatic cancer_Homo sapiens_hsa052120.54947649
133Antigen processing and presentation_Homo sapiens_hsa046120.53066709
134Colorectal cancer_Homo sapiens_hsa052100.48785023

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