NDFIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.24209763
2synaptic vesicle maturation (GO:0016188)5.03949912
3synaptic vesicle exocytosis (GO:0016079)4.73673051
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.69761135
5glutamate secretion (GO:0014047)4.60183415
6locomotory exploration behavior (GO:0035641)4.42667291
7regulation of synaptic vesicle exocytosis (GO:2000300)4.37187144
8vocalization behavior (GO:0071625)4.11570920
9cerebellar granule cell differentiation (GO:0021707)4.08808844
10postsynaptic membrane organization (GO:0001941)4.04340437
11neuron cell-cell adhesion (GO:0007158)4.04259056
12neurotransmitter secretion (GO:0007269)3.92656809
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.89322663
14regulation of synaptic vesicle transport (GO:1902803)3.85591837
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80538230
16neuronal ion channel clustering (GO:0045161)3.78402031
17exploration behavior (GO:0035640)3.76724577
18protein localization to synapse (GO:0035418)3.74311456
19layer formation in cerebral cortex (GO:0021819)3.72667969
20establishment of mitochondrion localization (GO:0051654)3.60093077
21regulation of glutamate receptor signaling pathway (GO:1900449)3.59226942
22cellular potassium ion homeostasis (GO:0030007)3.51134446
23neuronal action potential propagation (GO:0019227)3.49355554
24gamma-aminobutyric acid transport (GO:0015812)3.48397301
25presynaptic membrane organization (GO:0097090)3.47196191
26proline transport (GO:0015824)3.46009564
27mating behavior (GO:0007617)3.44102430
28regulation of neuronal synaptic plasticity (GO:0048168)3.40421408
29L-amino acid import (GO:0043092)3.34222681
30presynaptic membrane assembly (GO:0097105)3.33322585
31activation of protein kinase A activity (GO:0034199)3.30652151
32regulation of synapse structural plasticity (GO:0051823)3.30643183
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.27493107
34sodium ion export (GO:0071436)3.26806167
35amino acid import (GO:0043090)3.26355713
36neurotransmitter transport (GO:0006836)3.23939490
37potassium ion import (GO:0010107)3.23825860
38auditory behavior (GO:0031223)3.21798096
39synaptic vesicle docking involved in exocytosis (GO:0016081)3.16286681
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11485503
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.09477462
42regulation of neurotransmitter levels (GO:0001505)3.07865009
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07854873
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05735577
45neuron recognition (GO:0008038)3.02928238
46adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.00991943
47detection of calcium ion (GO:0005513)3.00109782
48neuromuscular process controlling posture (GO:0050884)2.99213732
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98097282
50regulation of ARF protein signal transduction (GO:0032012)2.97851568
51positive regulation of dendritic spine development (GO:0060999)2.97073070
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94902334
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.94557514
54neurotransmitter-gated ion channel clustering (GO:0072578)2.93261437
55neuron-neuron synaptic transmission (GO:0007270)2.91719799
56regulation of voltage-gated calcium channel activity (GO:1901385)2.90737709
57innervation (GO:0060384)2.90262915
58synaptic transmission, glutamatergic (GO:0035249)2.90165594
59dendritic spine organization (GO:0097061)2.89898984
60regulation of vesicle fusion (GO:0031338)2.88820801
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.88645967
62mitochondrion transport along microtubule (GO:0047497)2.88645967
63transmission of nerve impulse (GO:0019226)2.88511489
64glutamate receptor signaling pathway (GO:0007215)2.88172204
65dendritic spine morphogenesis (GO:0060997)2.88093764
66cell communication by electrical coupling (GO:0010644)2.84790804
67axon ensheathment in central nervous system (GO:0032291)2.79441526
68central nervous system myelination (GO:0022010)2.79441526
69positive regulation of membrane potential (GO:0045838)2.78857638
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77791298
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.77092989
72dendrite morphogenesis (GO:0048813)2.76921235
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75540137
74acidic amino acid transport (GO:0015800)2.75080500
75positive regulation of dendritic spine morphogenesis (GO:0061003)2.74503905
76pyrimidine nucleobase catabolic process (GO:0006208)2.74265168
77startle response (GO:0001964)2.73829215
78gamma-aminobutyric acid signaling pathway (GO:0007214)2.72585436
79regulation of synapse maturation (GO:0090128)2.72222613
80positive regulation of synapse assembly (GO:0051965)2.71501316
81positive regulation of neurotransmitter transport (GO:0051590)2.71448436
82positive regulation of neurotransmitter secretion (GO:0001956)2.71415127
83long-term memory (GO:0007616)2.70803108
84regulation of excitatory postsynaptic membrane potential (GO:0060079)2.69982125
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.69413771
86negative regulation of microtubule polymerization (GO:0031115)2.68750062
87vesicle transport along microtubule (GO:0047496)2.68518893
88regulation of neurotransmitter secretion (GO:0046928)2.68377085
89regulation of synaptic transmission, glutamatergic (GO:0051966)2.65909692
90axon cargo transport (GO:0008088)2.64490271
91organelle transport along microtubule (GO:0072384)2.64348146
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.63620821
93regulation of synaptic plasticity (GO:0048167)2.63164369
94regulation of postsynaptic membrane potential (GO:0060078)2.62422554
95synapse assembly (GO:0007416)2.62314594
96synaptic vesicle endocytosis (GO:0048488)2.62125590
97positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61767351
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.61460139
99long-term synaptic potentiation (GO:0060291)2.59788554
100cellular sodium ion homeostasis (GO:0006883)2.59133142
101neuromuscular process controlling balance (GO:0050885)2.57837256
102prepulse inhibition (GO:0060134)2.56273475
103response to pheromone (GO:0019236)2.54909713
104detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.53984707
105detection of temperature stimulus involved in sensory perception (GO:0050961)2.53984707
106response to auditory stimulus (GO:0010996)2.53947892
107axonal fasciculation (GO:0007413)2.53408663
108positive regulation of potassium ion transmembrane transport (GO:1901381)2.52772899
109synaptic vesicle transport (GO:0048489)2.52295814
110establishment of synaptic vesicle localization (GO:0097480)2.52295814
111membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51831931
112nucleobase catabolic process (GO:0046113)2.50450329
113membrane depolarization during action potential (GO:0086010)2.49283871
114regulation of neurotransmitter transport (GO:0051588)2.48770349
115cerebellar Purkinje cell layer development (GO:0021680)2.47382784
116alanine transport (GO:0032328)2.46665178
117regulation of calcium ion-dependent exocytosis (GO:0017158)2.46614949
118potassium ion homeostasis (GO:0055075)2.46481192
119behavioral response to cocaine (GO:0048148)2.46226393
120membrane hyperpolarization (GO:0060081)2.45792082
121synapse organization (GO:0050808)2.44878849
122regulation of dendritic spine morphogenesis (GO:0061001)2.43278884
123synaptic transmission (GO:0007268)2.43053706
124clathrin coat assembly (GO:0048268)2.42950715
125cerebellar Purkinje cell differentiation (GO:0021702)2.42901310
126positive regulation of synapse maturation (GO:0090129)2.42376699
127cell migration in hindbrain (GO:0021535)2.39204960
128establishment of vesicle localization (GO:0051650)2.39031442
129membrane depolarization (GO:0051899)2.37659895
130regulation of glutamate secretion (GO:0014048)2.36361005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.36701780
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93016878
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90284447
4GBX2_23144817_ChIP-Seq_PC3_Human2.86397080
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63761534
6REST_21632747_ChIP-Seq_MESCs_Mouse2.56309644
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53096869
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50225590
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46953504
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46953504
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45671114
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42981104
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41584123
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37634726
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.23057975
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19059142
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16771939
18DROSHA_22980978_ChIP-Seq_HELA_Human2.16336068
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.14112484
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.13757777
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.12582416
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.06117980
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96118617
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91442891
25TAF15_26573619_Chip-Seq_HEK293_Human1.88393402
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.82581257
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73072545
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.70901511
29AR_21572438_ChIP-Seq_LNCaP_Human1.70351027
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65493671
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.64794479
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55551899
33ZNF274_21170338_ChIP-Seq_K562_Hela1.52216529
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51572763
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50757993
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48646581
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44908112
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.42758779
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42211406
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36679118
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32006194
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.29282981
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28888937
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28220708
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24596836
46* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24041510
47RNF2_27304074_Chip-Seq_NSC_Mouse1.23974061
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21648520
49* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20061337
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19107256
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18310678
52P300_19829295_ChIP-Seq_ESCs_Human1.17898616
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16168910
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16111114
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.15453075
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13731380
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12505304
58AR_25329375_ChIP-Seq_VCAP_Human1.12126092
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12108502
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12033229
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.11184996
62* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09121256
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08814574
64* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07428582
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06169195
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05174300
67AR_19668381_ChIP-Seq_PC3_Human1.03892754
68* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01748870
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00940389
70* SMAD3_21741376_ChIP-Seq_EPCs_Human1.00664499
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00462677
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00385769
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00365930
74* STAT3_23295773_ChIP-Seq_U87_Human0.98718113
75BCAT_22108803_ChIP-Seq_LS180_Human0.97548679
76ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95279710
77BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95020575
78ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94378569
79CTCF_27219007_Chip-Seq_Bcells_Human0.94350221
80IGF1R_20145208_ChIP-Seq_DFB_Human0.94199736
81KDM2B_26808549_Chip-Seq_K562_Human0.94080731
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93526959
83RXR_22158963_ChIP-Seq_LIVER_Mouse0.93414210
84CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92027569
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91346174
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91194922
87* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90651292
88* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90578883
89* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89696512
90TP53_20018659_ChIP-ChIP_R1E_Mouse0.89369780
91SMAD_19615063_ChIP-ChIP_OVARY_Human0.89270268
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88693704
93EP300_21415370_ChIP-Seq_HL-1_Mouse0.88454849
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.88251231
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88120134
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87358931
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86852282
98* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86666245
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.85676813
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.85588382
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84353159
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84150921
103P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83631908
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83312276
105* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83015233
106WT1_19549856_ChIP-ChIP_CCG9911_Human0.82599284
107AHR_22903824_ChIP-Seq_MCF-7_Human0.81255080
108RING1B_27294783_Chip-Seq_NPCs_Mouse0.80919721
109* SMAD4_21741376_ChIP-Seq_EPCs_Human0.80200286
110* SMAD3_21741376_ChIP-Seq_ESCs_Human0.80117537
111CBX2_27304074_Chip-Seq_ESCs_Mouse0.79869143
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79527434
113* RUNX2_22187159_ChIP-Seq_PCA_Human0.78928403
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78761543
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.78559046
116* TCF4_23295773_ChIP-Seq_U87_Human0.78220603
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77588220
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77392081
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75695057
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.75180147
121* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74133621
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.73669236
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.73669236
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73643035
125KDM2B_26808549_Chip-Seq_REH_Human0.73160950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.10511786
2MP0003880_abnormal_central_pattern4.19504853
3MP0003635_abnormal_synaptic_transmissio3.54457249
4MP0004270_analgesia3.42248813
5MP0001968_abnormal_touch/_nociception3.04143120
6MP0009745_abnormal_behavioral_response2.92390364
7MP0002064_seizures2.82505871
8MP0003329_amyloid_beta_deposits2.81449687
9MP0002063_abnormal_learning/memory/cond2.77401948
10MP0009046_muscle_twitch2.56241374
11MP0002735_abnormal_chemical_nociception2.53512596
12MP0002734_abnormal_mechanical_nocicepti2.51268109
13MP0006276_abnormal_autonomic_nervous2.44239731
14MP0005423_abnormal_somatic_nervous2.42722103
15MP0002822_catalepsy2.40349994
16MP0002572_abnormal_emotion/affect_behav2.33991735
17MP0002272_abnormal_nervous_system2.32316113
18MP0002909_abnormal_adrenal_gland2.31766333
19MP0002733_abnormal_thermal_nociception2.28528227
20MP0002736_abnormal_nociception_after2.28161997
21MP0004858_abnormal_nervous_system2.13146754
22MP0001501_abnormal_sleep_pattern2.09649952
23MP0001440_abnormal_grooming_behavior2.07735810
24MP0001486_abnormal_startle_reflex2.06545356
25MP0001970_abnormal_pain_threshold2.01435549
26MP0002139_abnormal_hepatobiliary_system1.93851236
27MP0001984_abnormal_olfaction1.84198101
28MP0002067_abnormal_sensory_capabilities1.83323131
29MP0009780_abnormal_chondrocyte_physiolo1.82113547
30MP0003787_abnormal_imprinting1.76302822
31MP0000604_amyloidosis1.72914412
32MP0002184_abnormal_innervation1.70863394
33MP0005386_behavior/neurological_phenoty1.66140337
34MP0004924_abnormal_behavior1.66140337
35MP0001905_abnormal_dopamine_level1.62241837
36MP0002557_abnormal_social/conspecific_i1.51364612
37MP0004811_abnormal_neuron_physiology1.50805363
38MP0001529_abnormal_vocalization1.48959939
39MP0008569_lethality_at_weaning1.48250264
40MP0000955_abnormal_spinal_cord1.43864745
41MP0000778_abnormal_nervous_system1.39497053
42MP0001502_abnormal_circadian_rhythm1.37092800
43MP0005360_urolithiasis1.36761908
44MP0003633_abnormal_nervous_system1.34577702
45MP0003879_abnormal_hair_cell1.34474992
46MP0002837_dystrophic_cardiac_calcinosis1.34221768
47MP0000013_abnormal_adipose_tissue1.34217504
48MP0005535_abnormal_body_temperature1.29022139
49MP0002066_abnormal_motor_capabilities/c1.27788946
50MP0002882_abnormal_neuron_morphology1.24599577
51MP0005646_abnormal_pituitary_gland1.23591983
52MP0004142_abnormal_muscle_tone1.21911338
53MP0008875_abnormal_xenobiotic_pharmacok1.21862440
54MP0003123_paternal_imprinting1.20635603
55MP0004885_abnormal_endolymph1.20220671
56MP0002638_abnormal_pupillary_reflex1.19116358
57MP0005085_abnormal_gallbladder_physiolo1.19039640
58MP0002090_abnormal_vision1.18624042
59MP0003690_abnormal_glial_cell1.15405473
60MP0008872_abnormal_physiological_respon1.14169986
61MP0002229_neurodegeneration1.12469999
62MP0005551_abnormal_eye_electrophysiolog1.11305406
63MP0003631_nervous_system_phenotype1.10791112
64MP0003122_maternal_imprinting1.10284734
65MP0010386_abnormal_urinary_bladder1.05740430
66MP0005645_abnormal_hypothalamus_physiol1.05455646
67MP0001188_hyperpigmentation1.04875517
68MP0003634_abnormal_glial_cell1.04630522
69MP0005365_abnormal_bile_salt1.02483433
70MP0003195_calcinosis1.00227707
71MP0000920_abnormal_myelination0.99943345
72MP0002069_abnormal_eating/drinking_beha0.98888075
73MP0003121_genomic_imprinting0.97043208
74MP0008874_decreased_physiological_sensi0.91212887
75MP0008961_abnormal_basal_metabolism0.88774827
76MP0005083_abnormal_biliary_tract0.88599260
77MP0003632_abnormal_nervous_system0.83777562
78MP0002876_abnormal_thyroid_physiology0.82331162
79MP0000639_abnormal_adrenal_gland0.81804982
80MP0010329_abnormal_lipoprotein_level0.81533368
81MP0005623_abnormal_meninges_morphology0.81366613
82MP0002152_abnormal_brain_morphology0.79740800
83MP0004742_abnormal_vestibular_system0.78098976
84MP0000751_myopathy0.77611667
85MP0010234_abnormal_vibrissa_follicle0.77210217
86MP0004043_abnormal_pH_regulation0.77172458
87MP0002653_abnormal_ependyma_morphology0.76535834
88MP0004130_abnormal_muscle_cell0.73704756
89MP0006072_abnormal_retinal_apoptosis0.73311460
90MP0001664_abnormal_digestion0.73190193
91MP0005332_abnormal_amino_acid0.72202257
92MP0005409_darkened_coat_color0.71703375
93MP0003075_altered_response_to0.71226801
94MP0005584_abnormal_enzyme/coenzyme_acti0.70883180
95MP0000569_abnormal_digit_pigmentation0.70002228
96MP0003172_abnormal_lysosome_physiology0.69358593
97MP0004147_increased_porphyrin_level0.67469632
98MP0005448_abnormal_energy_balance0.66635108
99MP0005248_abnormal_Harderian_gland0.66278647
100MP0001765_abnormal_ion_homeostasis0.65507488
101MP0001348_abnormal_lacrimal_gland0.65266020
102MP0002752_abnormal_somatic_nervous0.65097498
103MP0003283_abnormal_digestive_organ0.65027113
104MP0002118_abnormal_lipid_homeostasis0.64701819
105MP0002078_abnormal_glucose_homeostasis0.64665108
106MP0001177_atelectasis0.63761205
107MP0003868_abnormal_feces_composition0.63379663
108MP0004145_abnormal_muscle_electrophysio0.63341264
109MP0001963_abnormal_hearing_physiology0.62567707
110MP0004085_abnormal_heartbeat0.62553534
111MP0000747_muscle_weakness0.62394369
112MP0001943_abnormal_respiration0.60749427
113MP0000026_abnormal_inner_ear0.60026044
114MP0005187_abnormal_penis_morphology0.58237688
115MP0001958_emphysema0.58156020
116MP0010769_abnormal_survival0.57159222
117MP0002082_postnatal_lethality0.54818931
118MP0010770_preweaning_lethality0.54818931
119MP0003861_abnormal_nervous_system0.54419916
120MP0003183_abnormal_peptide_metabolism0.53401852
121MP0010768_mortality/aging0.52982142
122MP0001299_abnormal_eye_distance/0.51772642
123MP0004510_myositis0.50512388
124MP0005167_abnormal_blood-brain_barrier0.50349888
125MP0000681_abnormal_thyroid_gland0.50234933
126MP0001485_abnormal_pinna_reflex0.49157947
127MP0005394_taste/olfaction_phenotype0.48590490
128MP0005499_abnormal_olfactory_system0.48590490

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.50607285
2Focal motor seizures (HP:0011153)5.25675523
3Visual hallucinations (HP:0002367)4.63977558
4Focal seizures (HP:0007359)4.37633946
5Atonic seizures (HP:0010819)3.84903246
6Supranuclear gaze palsy (HP:0000605)3.82794879
7Neurofibrillary tangles (HP:0002185)3.69104142
8Pheochromocytoma (HP:0002666)3.66837873
9Cerebral inclusion bodies (HP:0100314)3.56081304
10Action tremor (HP:0002345)3.55418249
11Absence seizures (HP:0002121)3.51329618
12Epileptic encephalopathy (HP:0200134)3.40678627
13Neuroendocrine neoplasm (HP:0100634)3.35136967
14Ankle clonus (HP:0011448)3.31036703
15Generalized tonic-clonic seizures (HP:0002069)3.27375199
16Progressive cerebellar ataxia (HP:0002073)3.24996501
17Dialeptic seizures (HP:0011146)3.08533826
18Limb dystonia (HP:0002451)3.00761275
19Anxiety (HP:0000739)2.97957644
20Abnormal eating behavior (HP:0100738)2.96636165
21Termporal pattern (HP:0011008)2.93999605
22Insidious onset (HP:0003587)2.93999605
23Febrile seizures (HP:0002373)2.92744814
24Depression (HP:0000716)2.91212671
25Obstructive sleep apnea (HP:0002870)2.90906089
26Agitation (HP:0000713)2.76659770
27Spastic gait (HP:0002064)2.76117156
28Progressive inability to walk (HP:0002505)2.72091348
29Mutism (HP:0002300)2.72001672
30Truncal ataxia (HP:0002078)2.70573178
31Urinary urgency (HP:0000012)2.68792573
32Impaired vibration sensation in the lower limbs (HP:0002166)2.66835000
33Peripheral hypomyelination (HP:0007182)2.66579956
34Abnormality of the corticospinal tract (HP:0002492)2.63770390
35Torticollis (HP:0000473)2.60017529
36Polyphagia (HP:0002591)2.57641400
37Dysmetria (HP:0001310)2.55254504
38Hyperventilation (HP:0002883)2.55208518
39Postural instability (HP:0002172)2.53654280
40Intention tremor (HP:0002080)2.53638603
41Poor eye contact (HP:0000817)2.51071334
42Impaired social interactions (HP:0000735)2.49689623
43Abnormal social behavior (HP:0012433)2.49689623
44Apathy (HP:0000741)2.48155898
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46102751
46Urinary bladder sphincter dysfunction (HP:0002839)2.45717560
47Scanning speech (HP:0002168)2.44604926
48Sleep apnea (HP:0010535)2.42351751
49Focal dystonia (HP:0004373)2.41419148
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38258639
51Dysdiadochokinesis (HP:0002075)2.37522792
52EEG with generalized epileptiform discharges (HP:0011198)2.36740595
53Craniofacial dystonia (HP:0012179)2.34347563
54Epileptiform EEG discharges (HP:0011182)2.32487307
55Diminished motivation (HP:0000745)2.32122135
56Cerebral hemorrhage (HP:0001342)2.28900547
57Papilledema (HP:0001085)2.27365559
58Hypsarrhythmia (HP:0002521)2.26072852
59Status epilepticus (HP:0002133)2.25832346
60Abnormality of the lower motor neuron (HP:0002366)2.23767306
61Bradykinesia (HP:0002067)2.22199895
62Lower limb muscle weakness (HP:0007340)2.18157280
63Diplopia (HP:0000651)2.17273622
64Abnormality of binocular vision (HP:0011514)2.17273622
65Failure to thrive in infancy (HP:0001531)2.14789015
66Megalencephaly (HP:0001355)2.14584437
67Hammertoe (HP:0001765)2.14500406
68Amyotrophic lateral sclerosis (HP:0007354)2.13904161
69Amblyopia (HP:0000646)2.12452195
70Drooling (HP:0002307)2.11935512
71Excessive salivation (HP:0003781)2.11935512
72Delusions (HP:0000746)2.09224489
73Annular pancreas (HP:0001734)2.08264056
74Insomnia (HP:0100785)2.07553769
75Clonus (HP:0002169)2.07023202
76Rigidity (HP:0002063)2.06344385
77Hypercortisolism (HP:0001578)2.06100315
78Hemiparesis (HP:0001269)2.05475110
79Psychosis (HP:0000709)2.04152102
80Akinesia (HP:0002304)2.01522536
81Split foot (HP:0001839)2.00925523
82Morphological abnormality of the pyramidal tract (HP:0002062)2.00190485
83Neoplasm of the peripheral nervous system (HP:0100007)1.98014589
84Inability to walk (HP:0002540)1.96490927
85Broad-based gait (HP:0002136)1.96245383
86Fetal akinesia sequence (HP:0001989)1.95780605
87Deep venous thrombosis (HP:0002625)1.95448753
88Hemiplegia (HP:0002301)1.95114544
89Growth hormone excess (HP:0000845)1.94537676
90Spinal canal stenosis (HP:0003416)1.93564666
91Hypoventilation (HP:0002791)1.93536001
92Absent speech (HP:0001344)1.93357416
93Retinal dysplasia (HP:0007973)1.92703386
94Generalized myoclonic seizures (HP:0002123)1.91554626
95Mild short stature (HP:0003502)1.89679304
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89365666
97Degeneration of the lateral corticospinal tracts (HP:0002314)1.89365666
98Ketoacidosis (HP:0001993)1.89334624
99Gaze-evoked nystagmus (HP:0000640)1.89085778
100Turricephaly (HP:0000262)1.86104148
101Ventricular fibrillation (HP:0001663)1.86047830
102Tetraplegia (HP:0002445)1.85392447
103Hand muscle atrophy (HP:0009130)1.84272177
104Postural tremor (HP:0002174)1.83996008
105Increased circulating renin level (HP:0000848)1.83733542
106Gout (HP:0001997)1.83602110
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83012202
108Heterochromia iridis (HP:0001100)1.81518437
109Rapidly progressive (HP:0003678)1.80873527
110Neuronal loss in central nervous system (HP:0002529)1.80669958
111Spastic tetraparesis (HP:0001285)1.80135692
112Gait ataxia (HP:0002066)1.79137463
113Blue irides (HP:0000635)1.78976914
114Spastic tetraplegia (HP:0002510)1.78922459
115Poor suck (HP:0002033)1.78273489
116Lower limb asymmetry (HP:0100559)1.77666155
117Type II lissencephaly (HP:0007260)1.76198779
118Sensorimotor neuropathy (HP:0007141)1.75942712
119Abnormality of calcium-phosphate metabolism (HP:0100530)1.75725459
120Stereotypic behavior (HP:0000733)1.74054185
121Bundle branch block (HP:0011710)1.73235009
122Abnormality of pain sensation (HP:0010832)1.72268933
123Impaired pain sensation (HP:0007328)1.72268933
124Foot dorsiflexor weakness (HP:0009027)1.72205834
125Impaired vibratory sensation (HP:0002495)1.70855794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.81722320
2NTRK33.79913271
3MARK13.33409367
4EPHA42.90497471
5MINK12.81174957
6MAP3K42.71220893
7MAP3K122.52733239
8NTRK12.47233749
9KSR22.43510784
10PAK62.24123632
11MAP2K72.21731013
12MAP2K42.06566050
13DAPK22.02778669
14NTRK21.98099090
15RIPK11.85367480
16ARAF1.79405766
17MAP3K21.65805411
18CAMKK11.55376718
19GRK51.52098208
20CDK51.49377437
21KSR11.48692097
22LMTK21.42122674
23PHKG21.38886599
24PHKG11.38886599
25PRKD31.36907391
26PNCK1.36579956
27PAK31.24982844
28CAMKK21.24668932
29UHMK11.23577608
30RET1.20994056
31PRKCG1.19542962
32CSNK1G21.13377683
33RIPK41.12567780
34MAP3K131.10825777
35PRPF4B1.09979873
36TYRO31.07213219
37TNIK1.06851298
38PRKCH1.06594781
39MAPK131.06283702
40LATS21.05043721
41TESK11.04022427
42WNK41.01568406
43MOS1.00105129
44CDK140.97399870
45DAPK10.96713334
46CASK0.96525555
47PLK20.93699082
48CDK190.92457347
49SIK20.91957575
50SCYL20.91731911
51CAMK2A0.91221643
52OXSR10.91102747
53CDK180.88933938
54MAP3K10.88378977
55FES0.88235481
56STK380.87936161
57CDK150.87059969
58EPHA30.84706638
59WNK30.83363792
60SGK4940.82973980
61SGK2230.82973980
62LIMK10.81187391
63STK390.80685442
64CAMK2B0.75205595
65RAF10.75152920
66CSNK1G30.74289704
67CDK11A0.73818217
68MAPK120.73159706
69FER0.72808137
70CAMK2G0.71069421
71EPHB20.67680221
72MAP2K10.66726034
73CAMK40.65665324
74NEK60.64085533
75PRKCZ0.62500873
76DYRK20.60848154
77DYRK1A0.60823828
78MAPK100.60689057
79PDPK10.60368059
80PDK10.59450201
81CAMK2D0.58093319
82TAOK10.57739793
83PINK10.57701149
84ERBB30.56318273
85STK110.55098844
86PRKCE0.54653987
87PTK2B0.54567989
88CAMK10.54100545
89EPHB10.54020100
90FYN0.53792897
91DYRK1B0.52973272
92PKN10.52780068
93TNK20.52599990
94MARK20.51146306
95BCR0.49776568
96WNK10.49065682
97PDGFRA0.48791460
98CAMK1G0.47189832
99PTK20.46918098
100MAPKAPK50.46741518
101FGFR20.45975438
102ROCK20.45462481
103FGFR40.42664541
104RPS6KA20.41691950
105MAP3K110.41045533
106SIK30.39764543
107SGK20.39326928
108CSNK1G10.39270245
109ERBB20.38595043
110SGK10.36484273
111CSNK1A1L0.36417360
112RPS6KA30.36054639
113SRC0.35672446
114MAP2K60.35306695
115ALK0.35131084
116PRKACG0.35106866
117FGR0.34273264
118IRAK20.34183344
119NME10.34070191
120SGK30.33789856
121JAK20.31021151

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.26024933
2Nicotine addiction_Homo sapiens_hsa050332.84255507
3GABAergic synapse_Homo sapiens_hsa047272.34679119
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.34570059
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10275649
6Circadian entrainment_Homo sapiens_hsa047131.97935801
7Olfactory transduction_Homo sapiens_hsa047401.93691563
8Long-term potentiation_Homo sapiens_hsa047201.91008815
9Nitrogen metabolism_Homo sapiens_hsa009101.88915979
10Glutamatergic synapse_Homo sapiens_hsa047241.88810802
11Amphetamine addiction_Homo sapiens_hsa050311.88178567
12Dopaminergic synapse_Homo sapiens_hsa047281.83308273
13Insulin secretion_Homo sapiens_hsa049111.82807199
14Morphine addiction_Homo sapiens_hsa050321.81656440
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78230048
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77682084
17Collecting duct acid secretion_Homo sapiens_hsa049661.75765226
18Salivary secretion_Homo sapiens_hsa049701.64284836
19Cocaine addiction_Homo sapiens_hsa050301.53522004
20Cholinergic synapse_Homo sapiens_hsa047251.50902594
21Gastric acid secretion_Homo sapiens_hsa049711.48864174
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43301409
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41074353
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39561265
25Taste transduction_Homo sapiens_hsa047421.39108408
26Butanoate metabolism_Homo sapiens_hsa006501.38708008
27Renin secretion_Homo sapiens_hsa049241.32228500
28Serotonergic synapse_Homo sapiens_hsa047261.31144244
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.26397500
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24899308
31Vibrio cholerae infection_Homo sapiens_hsa051101.23587368
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16459332
33Bile secretion_Homo sapiens_hsa049761.15565802
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13201526
35Long-term depression_Homo sapiens_hsa047301.12679719
36Oxytocin signaling pathway_Homo sapiens_hsa049211.11009005
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05320328
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04652719
39GnRH signaling pathway_Homo sapiens_hsa049121.00374671
40Calcium signaling pathway_Homo sapiens_hsa040200.99871849
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98060781
42Arginine biosynthesis_Homo sapiens_hsa002200.98013732
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97737662
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96624173
45Gap junction_Homo sapiens_hsa045400.92942976
46Cardiac muscle contraction_Homo sapiens_hsa042600.88953807
47Type II diabetes mellitus_Homo sapiens_hsa049300.87919107
48Estrogen signaling pathway_Homo sapiens_hsa049150.86265805
49Oxidative phosphorylation_Homo sapiens_hsa001900.86095879
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82744080
51cAMP signaling pathway_Homo sapiens_hsa040240.81490661
52Axon guidance_Homo sapiens_hsa043600.81453142
53Prion diseases_Homo sapiens_hsa050200.80766968
54Pancreatic secretion_Homo sapiens_hsa049720.79137821
55Circadian rhythm_Homo sapiens_hsa047100.78260453
56Thyroid hormone synthesis_Homo sapiens_hsa049180.76005611
57Sulfur metabolism_Homo sapiens_hsa009200.75285385
58Alzheimers disease_Homo sapiens_hsa050100.73877891
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73800014
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73767504
61Dilated cardiomyopathy_Homo sapiens_hsa054140.73732057
62Ras signaling pathway_Homo sapiens_hsa040140.72640060
63Rap1 signaling pathway_Homo sapiens_hsa040150.69077623
64Vitamin B6 metabolism_Homo sapiens_hsa007500.66583660
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.66188568
66Parkinsons disease_Homo sapiens_hsa050120.66015402
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65730007
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65046968
69Renal cell carcinoma_Homo sapiens_hsa052110.64930343
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64152972
71Pyruvate metabolism_Homo sapiens_hsa006200.63380954
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61597465
73Melanogenesis_Homo sapiens_hsa049160.60846640
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59856990
75Fatty acid metabolism_Homo sapiens_hsa012120.58830383
76Glucagon signaling pathway_Homo sapiens_hsa049220.58496523
77AMPK signaling pathway_Homo sapiens_hsa041520.57132683
78Glioma_Homo sapiens_hsa052140.56799111
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56205556
80ErbB signaling pathway_Homo sapiens_hsa040120.55908160
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55303828
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54760845
83Endometrial cancer_Homo sapiens_hsa052130.54070893
84Inositol phosphate metabolism_Homo sapiens_hsa005620.52755818
85Phototransduction_Homo sapiens_hsa047440.51303248
86Dorso-ventral axis formation_Homo sapiens_hsa043200.50863664
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.48560128
88Histidine metabolism_Homo sapiens_hsa003400.47438782
89Oocyte meiosis_Homo sapiens_hsa041140.47418795
90Fatty acid degradation_Homo sapiens_hsa000710.46672364
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46484139
92mTOR signaling pathway_Homo sapiens_hsa041500.46396253
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45208183
94Tryptophan metabolism_Homo sapiens_hsa003800.44514041
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44198414
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43082639
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42759356
98Propanoate metabolism_Homo sapiens_hsa006400.42697190
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41256810
100Endocytosis_Homo sapiens_hsa041440.40299410
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40262078
102Type I diabetes mellitus_Homo sapiens_hsa049400.39487389
103Glycerolipid metabolism_Homo sapiens_hsa005610.39210161
104Prolactin signaling pathway_Homo sapiens_hsa049170.38656336
105Insulin signaling pathway_Homo sapiens_hsa049100.38349782
106Protein digestion and absorption_Homo sapiens_hsa049740.38257964
107Choline metabolism in cancer_Homo sapiens_hsa052310.37665456
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.36868643
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36570628
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.36358313
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36197150
112VEGF signaling pathway_Homo sapiens_hsa043700.36193043
113beta-Alanine metabolism_Homo sapiens_hsa004100.35773783
114PPAR signaling pathway_Homo sapiens_hsa033200.35134781
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34724189
116Tyrosine metabolism_Homo sapiens_hsa003500.34392332
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34264008
118Phenylalanine metabolism_Homo sapiens_hsa003600.33870344
119Arginine and proline metabolism_Homo sapiens_hsa003300.32884449
120Fatty acid biosynthesis_Homo sapiens_hsa000610.32354235
121Ovarian steroidogenesis_Homo sapiens_hsa049130.32119686
122Tight junction_Homo sapiens_hsa045300.31876893
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.31818641
124Fatty acid elongation_Homo sapiens_hsa000620.31256555
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.29743255
126MAPK signaling pathway_Homo sapiens_hsa040100.29570558
127Complement and coagulation cascades_Homo sapiens_hsa046100.29222972

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »