NDFIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.02337208
2hemidesmosome assembly (GO:0031581)6.33143835
3cytidine metabolic process (GO:0046087)5.18229974
4cytidine catabolic process (GO:0006216)5.18229974
5cytidine deamination (GO:0009972)5.18229974
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.67999735
7intestinal epithelial cell development (GO:0060576)4.43100792
8keratinocyte proliferation (GO:0043616)4.38580740
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.37026814
10synaptic vesicle exocytosis (GO:0016079)4.35762166
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.17236467
12synaptic vesicle maturation (GO:0016188)4.16667605
13neuronal action potential propagation (GO:0019227)4.13690692
14glutamate secretion (GO:0014047)4.02592386
15Golgi transport vesicle coating (GO:0048200)3.97357105
16COPI coating of Golgi vesicle (GO:0048205)3.97357105
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96923217
18regulation of synaptic vesicle exocytosis (GO:2000300)3.93387739
19proteasome assembly (GO:0043248)3.89697670
20vocalization behavior (GO:0071625)3.88398430
21establishment of skin barrier (GO:0061436)3.68437708
22neuron cell-cell adhesion (GO:0007158)3.65697169
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.63967742
24cellular potassium ion homeostasis (GO:0030007)3.56479904
25protein localization to synapse (GO:0035418)3.54577545
26NADH metabolic process (GO:0006734)3.44807474
27regulation of water loss via skin (GO:0033561)3.43374870
28regulation of synaptic vesicle transport (GO:1902803)3.42065895
29regulation of transforming growth factor beta1 production (GO:0032908)3.35967385
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.35515964
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.31276458
32locomotory exploration behavior (GO:0035641)3.30288235
33cellular sodium ion homeostasis (GO:0006883)3.29315994
34neurotransmitter secretion (GO:0007269)3.26291500
35glutamate receptor signaling pathway (GO:0007215)3.25995465
36regulation of neuronal synaptic plasticity (GO:0048168)3.20001354
37eosinophil chemotaxis (GO:0048245)3.18307785
38regulation of glutamate receptor signaling pathway (GO:1900449)3.17137950
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15173508
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.14280559
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13428815
42localization within membrane (GO:0051668)3.12952920
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11776742
44neuron recognition (GO:0008038)3.08459551
45layer formation in cerebral cortex (GO:0021819)3.07333384
46DNA deamination (GO:0045006)2.99986493
47negative regulation of keratinocyte proliferation (GO:0010839)2.98429119
48cellular protein complex localization (GO:0034629)2.98191736
49exploration behavior (GO:0035640)2.97899386
50keratinization (GO:0031424)2.97094496
51proline transport (GO:0015824)2.96927988
52gamma-aminobutyric acid transport (GO:0015812)2.96186393
53neuron-neuron synaptic transmission (GO:0007270)2.93928170
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.91932784
55transmission of nerve impulse (GO:0019226)2.91912859
56gap junction assembly (GO:0016264)2.88587287
57sodium ion export (GO:0071436)2.87580831
58negative regulation of neurotransmitter transport (GO:0051589)2.87127509
59synaptic transmission, glutamatergic (GO:0035249)2.83692166
60neurotransmitter transport (GO:0006836)2.82362833
61regulation of vesicle fusion (GO:0031338)2.80122370
62vesicle transport along microtubule (GO:0047496)2.79792980
63dendritic spine morphogenesis (GO:0060997)2.79765970
64ribosome assembly (GO:0042255)2.77894291
65regulation of synapse structural plasticity (GO:0051823)2.77461448
66potassium ion homeostasis (GO:0055075)2.75786554
67intermediate filament organization (GO:0045109)2.75448323
68eosinophil migration (GO:0072677)2.74347242
69regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73677919
70presynaptic membrane assembly (GO:0097105)2.73543099
71axonal fasciculation (GO:0007413)2.71447297
72regulation of excitatory postsynaptic membrane potential (GO:0060079)2.70156768
73negative regulation of dendrite morphogenesis (GO:0050774)2.69317053
74behavioral response to cocaine (GO:0048148)2.69235035
75long-term synaptic potentiation (GO:0060291)2.68201122
76regulation of glutamate secretion (GO:0014048)2.67266589
77COPII vesicle coating (GO:0048208)2.66804252
78negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66187215
79dendrite morphogenesis (GO:0048813)2.65568860
80regulation of synaptic plasticity (GO:0048167)2.64842544
81positive regulation of membrane potential (GO:0045838)2.64381488
82organelle transport along microtubule (GO:0072384)2.63203082
83multicellular organismal water homeostasis (GO:0050891)2.62416011
84mating behavior (GO:0007617)2.62364060
85cell communication by electrical coupling (GO:0010644)2.61806378
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.59023759
87regulation of neurotransmitter secretion (GO:0046928)2.58664208
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58617454
89apical protein localization (GO:0045176)2.57766728
90regulation of postsynaptic membrane potential (GO:0060078)2.57588967
91response to histamine (GO:0034776)2.57531425
92regulation of cellular amino acid metabolic process (GO:0006521)2.57409909
93negative regulation of neurotransmitter secretion (GO:0046929)2.57151416
94presynaptic membrane organization (GO:0097090)2.56882426
95detection of temperature stimulus involved in sensory perception (GO:0050961)2.56540944
96detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.56540944
97regulation of neurotransmitter levels (GO:0001505)2.55690547
98regulation of dendritic spine morphogenesis (GO:0061001)2.54561916
99activation of protein kinase A activity (GO:0034199)2.53975400
100fatty acid elongation (GO:0030497)2.53626224
101synapse assembly (GO:0007416)2.53596486
102tricarboxylic acid cycle (GO:0006099)2.52869289
103protein maturation by protein folding (GO:0022417)2.52818518
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52815217
105neurotransmitter-gated ion channel clustering (GO:0072578)2.50324047
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.49531176
107maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49462709
108phosphate ion transmembrane transport (GO:0035435)2.49238763
109neuromuscular process controlling posture (GO:0050884)2.48668293
110synaptic vesicle docking involved in exocytosis (GO:0016081)2.48651732
111membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48520496
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48437291
113regulation of keratinocyte proliferation (GO:0010837)2.48268287
114regulation of regulatory T cell differentiation (GO:0045589)2.47951109
115regulation of neurotransmitter transport (GO:0051588)2.47437836
116membrane hyperpolarization (GO:0060081)2.47232034
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.47121585
118innervation (GO:0060384)2.45778033
119cell migration in hindbrain (GO:0021535)2.45458593
120cerebellar Purkinje cell differentiation (GO:0021702)2.44237753
121membrane budding (GO:0006900)2.43639680
122terpenoid biosynthetic process (GO:0016114)2.41859873
123neuromuscular process controlling balance (GO:0050885)2.41198162
124long-chain fatty acid biosynthetic process (GO:0042759)2.40464392
125keratinocyte development (GO:0003334)2.39235621
126positive regulation of potassium ion transmembrane transport (GO:1901381)2.39099584
127regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.39079065
128calcium ion-dependent exocytosis (GO:0017156)2.37482036
129membrane raft organization (GO:0031579)2.36640524
130protein retention in ER lumen (GO:0006621)2.36529897
131positive regulation of synaptic transmission, GABAergic (GO:0032230)2.36270101
132regulation of dendritic spine development (GO:0060998)2.36038984
133membrane depolarization (GO:0051899)2.36035206
134neuronal ion channel clustering (GO:0045161)2.35966729
135nucleoside diphosphate biosynthetic process (GO:0009133)2.35419799
136postsynaptic membrane organization (GO:0001941)2.35346363
137membrane depolarization during action potential (GO:0086010)2.35237630
138protein targeting to Golgi (GO:0000042)2.35065596
139diterpenoid biosynthetic process (GO:0016102)2.34720946
140establishment of protein localization to mitochondrial membrane (GO:0090151)2.34582269
141negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.34408176
142adult walking behavior (GO:0007628)2.34175269
143negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.33852068
144positive regulation of potassium ion transport (GO:0043268)2.33800165
145sodium ion homeostasis (GO:0055078)2.33703489
146negative regulation of dendrite development (GO:2000171)2.33688363
147synaptic vesicle endocytosis (GO:0048488)2.33483886
148synaptic transmission (GO:0007268)2.33411183
149L-serine transport (GO:0015825)2.33075837
150long-term memory (GO:0007616)2.33014983
151regulation of heart rate by cardiac conduction (GO:0086091)2.31840847
152phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.31054282
153regulation of amyloid precursor protein catabolic process (GO:1902991)2.30577810
154detection of temperature stimulus (GO:0016048)2.30498938
155regulation of voltage-gated calcium channel activity (GO:1901385)2.30408203
156positive regulation of actin filament depolymerization (GO:0030836)2.30253787
157cell communication involved in cardiac conduction (GO:0086065)2.30008049
158negative regulation of ligase activity (GO:0051352)2.27403330
159negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.27403330
160cell adhesion mediated by integrin (GO:0033627)2.27331521
161cytoskeletal anchoring at plasma membrane (GO:0007016)2.27147120
162anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.26952725
163regulation of cell communication by electrical coupling (GO:0010649)2.26854827
164asymmetric protein localization (GO:0008105)2.26759210
165positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.26208507
166retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.23911658
167regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.22788599
168cell-substrate junction assembly (GO:0007044)2.22481351
169potassium ion import (GO:0010107)2.21199067
170polarized epithelial cell differentiation (GO:0030859)2.20535898
171regulation of cellular respiration (GO:0043457)2.20500972
172epidermis development (GO:0008544)2.19000128
173regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.18900152
174positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.18900152
175negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.17679766
176water homeostasis (GO:0030104)2.17267068
177nucleobase-containing small molecule interconversion (GO:0015949)2.15750745
178cardiac conduction (GO:0061337)2.13875888
179protein heterotetramerization (GO:0051290)2.13733678
180protein complex localization (GO:0031503)2.12103428
181cardiac muscle cell action potential involved in contraction (GO:0086002)2.11648327
182cellular zinc ion homeostasis (GO:0006882)2.11166215
183ventricular cardiac muscle cell action potential (GO:0086005)2.11000597
184regulation of translational termination (GO:0006449)2.10056179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.88586313
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.11507623
3EZH2_22144423_ChIP-Seq_EOC_Human4.38855577
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.26627904
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.99677354
6GBX2_23144817_ChIP-Seq_PC3_Human2.99486311
7AR_21909140_ChIP-Seq_LNCAP_Human2.86851559
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.82147338
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68616532
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66729470
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51549719
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41047161
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33388217
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27989408
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27473708
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21455469
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21455469
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21159103
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19736565
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19162123
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14812865
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.11111868
23* TAF15_26573619_Chip-Seq_HEK293_Human2.06625192
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.00876635
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00755544
26REST_21632747_ChIP-Seq_MESCs_Mouse2.00481942
27ZNF263_19887448_ChIP-Seq_K562_Human1.99516115
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96277220
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.91257258
30* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88117962
31* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88117962
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.87885924
33AR_21572438_ChIP-Seq_LNCaP_Human1.87232716
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79228209
35SOX2_20726797_ChIP-Seq_SW620_Human1.78280794
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.77095680
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75495300
38HTT_18923047_ChIP-ChIP_STHdh_Human1.75492753
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.73649027
40VDR_22108803_ChIP-Seq_LS180_Human1.68971040
41* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66107252
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64094585
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63518972
44DROSHA_22980978_ChIP-Seq_HELA_Human1.62155512
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60785547
46SMAD4_21799915_ChIP-Seq_A2780_Human1.57297954
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.54900088
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.54102399
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49294725
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49221832
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48581518
52* P300_19829295_ChIP-Seq_ESCs_Human1.48574910
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47821694
54* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46407625
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45215461
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.41901338
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.41334666
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41150432
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40073425
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37779181
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37596239
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37514577
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.37226082
64DCP1A_22483619_ChIP-Seq_HELA_Human1.37024163
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36625210
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36313387
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34050325
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31470170
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30379650
70AR_25329375_ChIP-Seq_VCAP_Human1.29245512
71TP63_23658742_ChIP-Seq_EP156T_Human1.29148063
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28775265
73IGF1R_20145208_ChIP-Seq_DFB_Human1.27532882
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27225133
75ZNF274_21170338_ChIP-Seq_K562_Hela1.25846746
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23403085
77* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22998083
78BCAT_22108803_ChIP-Seq_LS180_Human1.22805364
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22352861
80STAT3_23295773_ChIP-Seq_U87_Human1.21332192
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20958088
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20230356
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19160224
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19123601
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.17394004
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16813829
87* SOX2_21211035_ChIP-Seq_LN229_Gbm1.15461887
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14541390
89AHR_22903824_ChIP-Seq_MCF-7_Human1.13436502
90TP53_18474530_ChIP-ChIP_U2OS_Human1.12834996
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12526730
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.11959800
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11171105
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11171105
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10775823
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.10231814
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09602848
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09415403
99* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09206748
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.08601558
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08248683
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07208793
103TCF4_18268006_ChIP-ChIP_LS174T_Human1.07190180
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.07161257
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.06977736
106RXR_22108803_ChIP-Seq_LS180_Human1.06657754
107TP53_16413492_ChIP-PET_HCT116_Human1.05630291
108CLOCK_20551151_ChIP-Seq_293T_Human1.05229773
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04957125
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04451168
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02863849
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.02254050
113* GATA4_25053715_ChIP-Seq_YYC3_Human1.01837664
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.01637251
115EOMES_21245162_ChIP-Seq_HESCs_Human1.00944523
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00668551
117FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00210019
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.99642378
119RUNX2_22187159_ChIP-Seq_PCA_Human0.99389615
120FUS_26573619_Chip-Seq_HEK293_Human0.98797978
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98647877
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98451705
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96858448
124TCF4_23295773_ChIP-Seq_U87_Human0.95559819
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95275404
126* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95203990
127* KDM2B_26808549_Chip-Seq_REH_Human0.94982489
128ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94931545
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.94898026
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94747324
131SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94625926
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.94618352
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94373474
134RNF2_27304074_Chip-Seq_NSC_Mouse0.94343958
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.93936098
136GATA3_24758297_ChIP-Seq_MCF-7_Human0.93306299
137MYC_18555785_ChIP-Seq_MESCs_Mouse0.93149556
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.92902793
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92609593
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91852221
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91043366
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90670036
143SMAD4_21741376_ChIP-Seq_EPCs_Human0.90036616
144AR_19668381_ChIP-Seq_PC3_Human0.89599966
145SOX2_18555785_Chip-Seq_ESCs_Mouse0.89550822
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89434742
147HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89180973
148NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88992297
149* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88952555
150ER_23166858_ChIP-Seq_MCF-7_Human0.87523560
151EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87047584
152* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86811542
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86270667
154PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86050502
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.85220356
156ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85201906
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.85164497
158PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84976493
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84873820
160CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84672184
161ELK1_19687146_ChIP-ChIP_HELA_Human0.84539857
162CJUN_26792858_Chip-Seq_BT549_Human0.84354469
163REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83581583
164KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.83086188
165* ELF5_23300383_ChIP-Seq_T47D_Human0.82959463
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81676687
167FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80911110
168EZH2_27294783_Chip-Seq_NPCs_Mouse0.80726906
169THAP11_20581084_ChIP-Seq_MESCs_Mouse0.80494682
170CDX2_22108803_ChIP-Seq_LS180_Human0.80154455
171ATF3_27146783_Chip-Seq_COLON_Human0.80123485
172RBPJ_21746931_ChIP-Seq_IB4_Human0.79965582
173CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.79753119
174SOX17_20123909_ChIP-Seq_XEN_Mouse0.79727276
175ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78343598
176CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78088691
177SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77929596
178SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77267144
179PHF8_20622853_ChIP-Seq_HELA_Human0.76922063
180GATA6_25053715_ChIP-Seq_YYC3_Human0.76874700
181NANOG_18692474_ChIP-Seq_MEFs_Mouse0.76597061
182ETS1_20019798_ChIP-Seq_JURKAT_Human0.76596133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.78164466
2MP0004270_analgesia4.24438879
3MP0003880_abnormal_central_pattern4.18488249
4MP0003635_abnormal_synaptic_transmissio3.38589174
5MP0001968_abnormal_touch/_nociception3.19631263
6MP0003941_abnormal_skin_development2.96106377
7MP0009745_abnormal_behavioral_response2.83654913
8MP0002877_abnormal_melanocyte_morpholog2.83080657
9MP0002735_abnormal_chemical_nociception2.78891107
10MP0002063_abnormal_learning/memory/cond2.74013918
11MP0002734_abnormal_mechanical_nocicepti2.71597228
12MP0002064_seizures2.67149021
13MP0002736_abnormal_nociception_after2.63864673
14MP0009046_muscle_twitch2.63012908
15MP0002822_catalepsy2.53258388
16MP0003329_amyloid_beta_deposits2.50990868
17MP0005275_abnormal_skin_tensile2.44340884
18MP0002272_abnormal_nervous_system2.39316970
19MP0002733_abnormal_thermal_nociception2.36239716
20MP0002572_abnormal_emotion/affect_behav2.34584514
21MP0010234_abnormal_vibrissa_follicle2.31842456
22MP0005501_abnormal_skin_physiology2.25163506
23MP0005623_abnormal_meninges_morphology2.24332479
24MP0001486_abnormal_startle_reflex2.19139664
25MP0001440_abnormal_grooming_behavior2.14462105
26MP0001970_abnormal_pain_threshold2.12665926
27MP0006276_abnormal_autonomic_nervous2.06296924
28MP0001501_abnormal_sleep_pattern1.99746146
29MP0002234_abnormal_pharynx_morphology1.98099708
30MP0000566_synostosis1.91513647
31MP0002067_abnormal_sensory_capabilities1.88178496
32MP0004858_abnormal_nervous_system1.87135188
33MP0010352_gastrointestinal_tract_polyps1.85565144
34MP0000762_abnormal_tongue_morphology1.73815105
35MP0009780_abnormal_chondrocyte_physiolo1.71174485
36MP0001216_abnormal_epidermal_layer1.65769417
37MP0002909_abnormal_adrenal_gland1.65195304
38MP0000920_abnormal_myelination1.62108918
39MP0004782_abnormal_surfactant_physiolog1.60163953
40MP0002060_abnormal_skin_morphology1.58824476
41MP0000778_abnormal_nervous_system1.58127286
42MP0002184_abnormal_innervation1.57748161
43MP0001529_abnormal_vocalization1.57697945
44MP0005386_behavior/neurological_phenoty1.52525350
45MP0004924_abnormal_behavior1.52525350
46MP0000467_abnormal_esophagus_morphology1.52520505
47MP0005423_abnormal_somatic_nervous1.52291999
48MP0000604_amyloidosis1.48661997
49MP0008569_lethality_at_weaning1.46472711
50MP0002557_abnormal_social/conspecific_i1.43570949
51MP0001984_abnormal_olfaction1.43061094
52MP0002098_abnormal_vibrissa_morphology1.39506010
53MP0005360_urolithiasis1.35702658
54MP0004272_abnormal_basement_membrane1.35569558
55MP0003045_fibrosis1.35114078
56MP0003879_abnormal_hair_cell1.35049347
57MP0000955_abnormal_spinal_cord1.33957924
58MP0010386_abnormal_urinary_bladder1.33105673
59MP0003950_abnormal_plasma_membrane1.32157646
60MP0001346_abnormal_lacrimal_gland1.29186224
61MP0002796_impaired_skin_barrier1.29155956
62MP0004811_abnormal_neuron_physiology1.28738259
63MP0001905_abnormal_dopamine_level1.27845085
64MP0003566_abnormal_cell_adhesion1.27198061
65MP0003633_abnormal_nervous_system1.26391707
66MP0002066_abnormal_motor_capabilities/c1.23367274
67MP0004742_abnormal_vestibular_system1.22532784
68MP0005646_abnormal_pituitary_gland1.22269278
69MP0004215_abnormal_myocardial_fiber1.21900315
70MP0003786_premature_aging1.21032731
71MP0004147_increased_porphyrin_level1.20319884
72MP0004957_abnormal_blastocyst_morpholog1.20071375
73MP0000427_abnormal_hair_cycle1.19442291
74MP0002882_abnormal_neuron_morphology1.19061499
75MP0003453_abnormal_keratinocyte_physiol1.18704657
76MP0004142_abnormal_muscle_tone1.16600743
77MP0000377_abnormal_hair_follicle1.15076648
78MP0004264_abnormal_extraembryonic_tissu1.15021209
79MP0004885_abnormal_endolymph1.14615830
80MP0000383_abnormal_hair_follicle1.14099586
81MP0001188_hyperpigmentation1.13675511
82MP0002229_neurodegeneration1.07810884
83MP0003631_nervous_system_phenotype1.07313599
84MP0008875_abnormal_xenobiotic_pharmacok1.04471275
85MP0001664_abnormal_digestion1.03723687
86MP0003718_maternal_effect1.02245366
87MP0000647_abnormal_sebaceous_gland1.02221974
88MP0001502_abnormal_circadian_rhythm1.01381042
89MP0002139_abnormal_hepatobiliary_system1.00721342
90MP0005085_abnormal_gallbladder_physiolo1.00445107
91MP0003690_abnormal_glial_cell0.99759281
92MP0005409_darkened_coat_color0.99531259
93MP0003634_abnormal_glial_cell0.98571524
94MP0005535_abnormal_body_temperature0.97407918
95MP0004043_abnormal_pH_regulation0.96685011
96MP0005645_abnormal_hypothalamus_physiol0.96280531
97MP0001666_abnormal_nutrient_absorption0.95576272
98MP0002090_abnormal_vision0.94823391
99MP0000013_abnormal_adipose_tissue0.94360567
100MP0008872_abnormal_physiological_respon0.92073976
101MP0001853_heart_inflammation0.91885134
102MP0000627_abnormal_mammary_gland0.91212239
103MP0002876_abnormal_thyroid_physiology0.89565402
104MP0008438_abnormal_cutaneous_collagen0.87965413
105MP0002069_abnormal_eating/drinking_beha0.87704060
106MP0001765_abnormal_ion_homeostasis0.87456160
107MP0002177_abnormal_outer_ear0.87402188
108MP0008874_decreased_physiological_sensi0.86464155
109MP0001177_atelectasis0.86127376
110MP0000537_abnormal_urethra_morphology0.85487676
111MP0003705_abnormal_hypodermis_morpholog0.82540394
112MP0001299_abnormal_eye_distance/0.81337659
113MP0005187_abnormal_penis_morphology0.80169996
114MP0003632_abnormal_nervous_system0.79281929
115MP0003183_abnormal_peptide_metabolism0.77389806
116MP0001191_abnormal_skin_condition0.77260778
117MP0008932_abnormal_embryonic_tissue0.76097459
118MP0005551_abnormal_eye_electrophysiolog0.75919536
119MP0001963_abnormal_hearing_physiology0.75779667
120MP0004019_abnormal_vitamin_homeostasis0.75562014
121MP0002152_abnormal_brain_morphology0.75157208
122MP0005332_abnormal_amino_acid0.74590735
123MP0010678_abnormal_skin_adnexa0.74474463
124MP0003195_calcinosis0.73890490
125MP0001485_abnormal_pinna_reflex0.73300052
126MP0002254_reproductive_system_inflammat0.71873797
127MP0003075_altered_response_to0.71622036
128MP0005451_abnormal_body_composition0.71531899
129MP0003315_abnormal_perineum_morphology0.70028612
130MP0000367_abnormal_coat/_hair0.68783941
131MP0000462_abnormal_digestive_system0.68132528
132MP0002837_dystrophic_cardiac_calcinosis0.67882461
133MP0009697_abnormal_copulation0.67527441
134MP0001348_abnormal_lacrimal_gland0.67280000
135MP0000678_abnormal_parathyroid_gland0.65703466
136MP0001873_stomach_inflammation0.64084029
137MP0010771_integument_phenotype0.63524012
138MP0005330_cardiomyopathy0.63470216
139MP0005165_increased_susceptibility_to0.63376503
140MP0002160_abnormal_reproductive_system0.61689904
141MP0002752_abnormal_somatic_nervous0.61168343
142MP0008961_abnormal_basal_metabolism0.61163664
143MP0000538_abnormal_urinary_bladder0.60999970
144MP0006035_abnormal_mitochondrial_morpho0.60811401
145MP0001881_abnormal_mammary_gland0.60224404
146MP0003868_abnormal_feces_composition0.59667508
147MP0003693_abnormal_embryo_hatching0.59623448
148MP0001243_abnormal_dermal_layer0.59280192
149MP0000631_abnormal_neuroendocrine_gland0.58985379
150MP0005408_hypopigmentation0.58609085
151MP0005166_decreased_susceptibility_to0.58560430
152MP0000579_abnormal_nail_morphology0.57202188
153MP0009379_abnormal_foot_pigmentation0.56812116
154MP0004085_abnormal_heartbeat0.55288623
155MP0004484_altered_response_of0.52769494

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.28760287
2Myokymia (HP:0002411)5.50831986
3Onycholysis (HP:0001806)5.13184201
4Fragile nails (HP:0001808)5.12332672
5Focal seizures (HP:0007359)4.64757158
6Plantar hyperkeratosis (HP:0007556)4.62090215
7Atonic seizures (HP:0010819)4.61422465
8Right ventricular cardiomyopathy (HP:0011663)4.23498686
9Neurofibrillary tangles (HP:0002185)4.14503979
10Termporal pattern (HP:0011008)3.99343289
11Insidious onset (HP:0003587)3.99343289
12Milia (HP:0001056)3.93385048
13Absence seizures (HP:0002121)3.89902107
14Epileptic encephalopathy (HP:0200134)3.83561990
15Visual hallucinations (HP:0002367)3.82550981
16Supranuclear gaze palsy (HP:0000605)3.74751920
17Palmoplantar hyperkeratosis (HP:0000972)3.73534737
18Action tremor (HP:0002345)3.73122119
19Cerebral inclusion bodies (HP:0100314)3.68191783
20Abnormality of nail color (HP:0100643)3.66102108
21Febrile seizures (HP:0002373)3.57693804
22Palmar hyperkeratosis (HP:0010765)3.55570330
23Dialeptic seizures (HP:0011146)3.54944211
24Atrophic scars (HP:0001075)3.48722340
25Generalized tonic-clonic seizures (HP:0002069)3.43279162
26Alopecia of scalp (HP:0002293)3.38134270
27Sparse eyelashes (HP:0000653)3.37697878
28Ankle clonus (HP:0011448)3.34602355
29Ulnar claw (HP:0001178)3.21549109
30Hypotrichosis (HP:0001006)3.20542755
31Progressive cerebellar ataxia (HP:0002073)3.15697892
32Abnormality of the corticospinal tract (HP:0002492)3.12916838
33Thick nail (HP:0001805)3.09909807
34Degeneration of the lateral corticospinal tracts (HP:0002314)3.04870928
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.04870928
36Pili torti (HP:0003777)3.01124467
37Selective tooth agenesis (HP:0001592)2.98302803
38Dysmetria (HP:0001310)2.90367186
39Pheochromocytoma (HP:0002666)2.83216355
40Spastic gait (HP:0002064)2.73349111
41Scanning speech (HP:0002168)2.71814091
42Akinesia (HP:0002304)2.71066046
43Nail dystrophy (HP:0008404)2.70936379
44Hyperventilation (HP:0002883)2.70678366
45Urinary urgency (HP:0000012)2.67177242
46Congenital ichthyosiform erythroderma (HP:0007431)2.64697686
47Abnormality of oral frenula (HP:0000190)2.60947608
48Truncal ataxia (HP:0002078)2.59303476
49Abnormal hair laboratory examination (HP:0003328)2.59030170
50Palpitations (HP:0001962)2.57397794
51Dysdiadochokinesis (HP:0002075)2.55470622
52Abnormal eating behavior (HP:0100738)2.54510827
53Intention tremor (HP:0002080)2.53625260
54Anxiety (HP:0000739)2.50247962
55Neuroendocrine neoplasm (HP:0100634)2.47487802
56Oral leukoplakia (HP:0002745)2.46925504
57Onion bulb formation (HP:0003383)2.44876590
58Impaired vibration sensation in the lower limbs (HP:0002166)2.43851676
59Mutism (HP:0002300)2.41305741
60Septate vagina (HP:0001153)2.40541137
61Generalized myoclonic seizures (HP:0002123)2.38849745
62Amniotic constriction ring (HP:0009775)2.37415963
63Abnormality of placental membranes (HP:0011409)2.37415963
64Epileptiform EEG discharges (HP:0011182)2.37373570
65Urinary bladder sphincter dysfunction (HP:0002839)2.36248695
66Chronic diarrhea (HP:0002028)2.33454394
67EEG with generalized epileptiform discharges (HP:0011198)2.31542398
68Abnormal social behavior (HP:0012433)2.30657985
69Impaired social interactions (HP:0000735)2.30657985
70Peripheral hypomyelination (HP:0007182)2.29893692
71Depression (HP:0000716)2.28820512
72Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.28502653
73Segmental peripheral demyelination/remyelination (HP:0003481)2.27829670
74Progressive inability to walk (HP:0002505)2.27664254
75Gaze-evoked nystagmus (HP:0000640)2.25354463
76Abnormal blistering of the skin (HP:0008066)2.23447891
77Poor eye contact (HP:0000817)2.22624327
78Torticollis (HP:0000473)2.22405648
79Limb dystonia (HP:0002451)2.21442549
80Woolly hair (HP:0002224)2.20075590
81Amblyopia (HP:0000646)2.19310351
82Broad-based gait (HP:0002136)2.18505559
83Ridged nail (HP:0001807)2.16321772
84Dry hair (HP:0011359)2.15681900
85Hypsarrhythmia (HP:0002521)2.15198838
86Retinal dysplasia (HP:0007973)2.13098441
87Megalencephaly (HP:0001355)2.12178707
88Hammertoe (HP:0001765)2.11697908
89Sensory axonal neuropathy (HP:0003390)2.11213645
90Ankyloglossia (HP:0010296)2.11126037
91Reduced subcutaneous adipose tissue (HP:0003758)2.10758957
92Tetraparesis (HP:0002273)2.10617096
93Drooling (HP:0002307)2.10509748
94Excessive salivation (HP:0003781)2.10509748
95Postural instability (HP:0002172)2.08483308
96Polyphagia (HP:0002591)2.07738385
97Hypokinesia (HP:0002375)2.06593610
98Hoarse voice (HP:0001609)2.06582219
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05295838
100Hypoplasia of dental enamel (HP:0006297)2.04755881
101Hemiparesis (HP:0001269)2.04708714
102Status epilepticus (HP:0002133)2.04325637
103Lower limb muscle weakness (HP:0007340)2.04180760
104Ventricular fibrillation (HP:0001663)2.03867346
105Cerebral hemorrhage (HP:0001342)2.02906288
106Abnormality of glycolysis (HP:0004366)2.01545474
107Cerebral hypomyelination (HP:0006808)2.01234702
108Erythroderma (HP:0001019)2.00951961
109Increased serum pyruvate (HP:0003542)2.00945605
110Abnormality of the salivary glands (HP:0010286)1.99904125
111Focal dystonia (HP:0004373)1.98845377
112Pterygium (HP:0001059)1.98792044
113Diplopia (HP:0000651)1.98268298
114Abnormality of binocular vision (HP:0011514)1.98268298
115Aplasia involving bones of the extremities (HP:0009825)1.98071704
116Aplasia involving bones of the upper limbs (HP:0009823)1.98071704
117Aplasia of the phalanges of the hand (HP:0009802)1.98071704
118Craniofacial dystonia (HP:0012179)1.97715127
119Corneal erosion (HP:0200020)1.95826885
120Neuronal loss in central nervous system (HP:0002529)1.95685969
121Psychosis (HP:0000709)1.95499485
122Palmoplantar keratoderma (HP:0000982)1.94664689
123Confusion (HP:0001289)1.94136990
124Tetraplegia (HP:0002445)1.93636252
125Hypoplastic labia majora (HP:0000059)1.93000115
126Horizontal nystagmus (HP:0000666)1.92724529
127Conjunctival hamartoma (HP:0100780)1.92277163
128Fragile skin (HP:0001030)1.91263918
129Erythema (HP:0010783)1.91244845
130Postural tremor (HP:0002174)1.90493808
131Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88701547
132Clonus (HP:0002169)1.88606865
133Steppage gait (HP:0003376)1.87705756
134Aplasia cutis congenita (HP:0001057)1.86728099
135Distal sensory impairment (HP:0002936)1.86501862
136Thickened helices (HP:0000391)1.86342547
137Hypoplasia of the uterus (HP:0000013)1.86262854
138Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.86167168
139Agitation (HP:0000713)1.86066853
140Popliteal pterygium (HP:0009756)1.85852988
141Blue irides (HP:0000635)1.85741072
142Parakeratosis (HP:0001036)1.82437435
143Morphological abnormality of the pyramidal tract (HP:0002062)1.81761550
144Spinal cord compression (HP:0002176)1.81144480
145Absent eyelashes (HP:0000561)1.81086779
146Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80746823
147Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80746823
148Bradykinesia (HP:0002067)1.80508791
149Taurodontia (HP:0000679)1.78700657
150Abnormality of permanent molar morphology (HP:0011071)1.78700657
151Abnormality of the dental root (HP:0006486)1.78700657
152Abnormal gallbladder physiology (HP:0012438)1.76822889
153Cholecystitis (HP:0001082)1.76822889
154Hyperhidrosis (HP:0000975)1.76683737
155Megaloblastic anemia (HP:0001889)1.75280061
156Rigidity (HP:0002063)1.74336797
157Cutaneous melanoma (HP:0012056)1.73973569
158Nasolacrimal duct obstruction (HP:0000579)1.73734263
159Autoamputation (HP:0001218)1.73270988
160Delusions (HP:0000746)1.72769418
161Increased circulating renin level (HP:0000848)1.72465769
162Hypoglycemic coma (HP:0001325)1.69574999
163Ureteral stenosis (HP:0000071)1.69402508
164Absent speech (HP:0001344)1.69327359
165Fat malabsorption (HP:0002630)1.68969072
166Inability to walk (HP:0002540)1.68914459
167Abnormality of molar morphology (HP:0011070)1.68792365
168Abnormality of molar (HP:0011077)1.68792365
169Fetal akinesia sequence (HP:0001989)1.68481593
170Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68242693
171Papilledema (HP:0001085)1.67646042
172Proximal tubulopathy (HP:0000114)1.66283728
173Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66225722
174Rapidly progressive (HP:0003678)1.66146716
175Gait ataxia (HP:0002066)1.65589294
176Symptomatic seizures (HP:0011145)1.65136877
177Hypobetalipoproteinemia (HP:0003563)1.64786934
178Hyperactive renin-angiotensin system (HP:0000841)1.64738060
179Aplasia/hypoplasia of the uterus (HP:0008684)1.64390227
180Diminished movement (HP:0002374)1.64373939
181Atrioventricular block (HP:0001678)1.64087103
182Abnormality of the labia majora (HP:0012881)1.63300872
183Cardiovascular calcification (HP:0011915)1.63027783
184Ureteral obstruction (HP:0006000)1.62237022
185Vascular calcification (HP:0004934)1.61388160
186Abnormality of the vitamin B12 metabolism (HP:0004341)1.59243012
187Abnormalities of placenta or umbilical cord (HP:0001194)1.59067980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.71062886
2NTRK33.55115823
3MAP3K93.46919991
4KSR23.16714503
5EPHA22.97308271
6TXK2.92489328
7BUB12.80039714
8RIPK42.70336904
9NTRK12.50689939
10MAP3K22.46985742
11NEK12.36823345
12MARK12.32716039
13MAP3K42.27566036
14MINK12.19606943
15MAP3K122.13373422
16EIF2AK32.09584687
17PBK2.06808202
18STK242.04335902
19MAP2K72.01016536
20TESK11.97513820
21CASK1.97107815
22EIF2AK11.91264807
23TSSK61.86671094
24ARAF1.86426382
25STK391.85678586
26PAK61.83621441
27MAP2K41.83222907
28DAPK21.75928834
29PRKD31.73488784
30OXSR11.71399271
31MAPKAPK31.58650631
32BMPR21.56964467
33KSR11.56692988
34MAP3K131.56513347
35TTK1.50040677
36MST1R1.48381490
37GRK51.42634655
38TRIM281.38751018
39CDK51.34156469
40PNCK1.33887601
41NTRK21.31475523
42PDK21.31318772
43MYLK1.28968739
44MAPK131.26041605
45WNK41.25979211
46RIPK11.25150669
47PAK41.24861180
48PLK21.24450460
49MAP3K11.22624832
50CAMKK21.18447607
51RET1.13626127
52TNIK1.12004505
53PAK31.08304806
54SRPK11.07707667
55ERBB31.06910708
56CAMKK11.06763550
57CAMK2A1.03929213
58NME11.03028052
59FRK1.02223092
60MAPKAPK51.01797686
61ACVR1B1.01767593
62MAP2K11.00446098
63FGFR10.99377141
64BCR0.97769989
65CAMK2B0.97059884
66CSNK1G20.95632777
67RAF10.95576914
68LATS10.94320879
69STK38L0.92362400
70FER0.90148664
71SGK4940.89047217
72SGK2230.89047217
73CDK190.86302403
74LMTK20.83971294
75WNK10.82857758
76PRKCG0.81126807
77NEK60.78799520
78PRKCE0.77623459
79MST40.77489073
80BRSK10.76966288
81UHMK10.76424769
82LATS20.76413963
83CDK140.75652268
84SIK20.74480198
85LIMK10.70860977
86CAMK2G0.70790996
87MOS0.70482186
88STK110.70148978
89PRKCH0.68420924
90INSRR0.67899355
91PTK2B0.67515036
92CAMK2D0.66355610
93TYRO30.65251032
94FGR0.64658476
95CDK180.64197830
96PDPK10.63350315
97STK160.63009610
98MET0.62576601
99MARK20.62494892
100CDK150.62294800
101CSNK1A1L0.61973102
102FES0.60444241
103FGFR20.58216533
104PLK30.55605364
105STK380.53860641
106BRAF0.52500754
107ERBB40.52210024
108ROCK20.52157980
109ALK0.50571562
110EPHB10.50302829
111PRKCI0.50198697
112CDK11A0.50119039
113PHKG20.49709023
114PHKG10.49709023
115PDK10.49501938
116DYRK1A0.48500253
117PINK10.47631258
118SGK10.47604649
119PRKCZ0.47365362
120WNK30.47201109
121TAOK10.46234357
122BMPR1B0.45795783
123CSNK1G30.45219445
124PIK3CA0.45028727
125MUSK0.44117949
126MAP2K60.43477031
127DAPK10.43413990
128FYN0.43250166
129CCNB10.43142342
130EPHA30.42901432
131STK30.42302723
132AKT20.41302064
133PTK20.40715585
134PLK10.38571461
135AKT30.37964129
136SCYL20.37263484
137MAPK150.36753489
138PIM20.34663101
139PDGFRA0.33690052
140BRSK20.33144326
141EPHB20.31722501
142PRKG20.31216098

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.14501494
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.96085818
3Nicotine addiction_Homo sapiens_hsa050332.63003034
4Synaptic vesicle cycle_Homo sapiens_hsa047212.58641253
5Long-term potentiation_Homo sapiens_hsa047202.23311464
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12388693
7GABAergic synapse_Homo sapiens_hsa047272.05495863
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03787234
9Glutamatergic synapse_Homo sapiens_hsa047242.01678718
10Amphetamine addiction_Homo sapiens_hsa050311.99124816
11Vitamin B6 metabolism_Homo sapiens_hsa007501.96046766
12Circadian entrainment_Homo sapiens_hsa047131.95924445
13Dopaminergic synapse_Homo sapiens_hsa047281.85433761
14Protein export_Homo sapiens_hsa030601.83417966
15Olfactory transduction_Homo sapiens_hsa047401.83331606
16Morphine addiction_Homo sapiens_hsa050321.83184258
17Salivary secretion_Homo sapiens_hsa049701.82082479
18Collecting duct acid secretion_Homo sapiens_hsa049661.74050622
19Insulin secretion_Homo sapiens_hsa049111.71864434
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68955281
21Serotonergic synapse_Homo sapiens_hsa047261.66958517
22Nitrogen metabolism_Homo sapiens_hsa009101.66014332
23Gastric acid secretion_Homo sapiens_hsa049711.64222592
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62576612
25Long-term depression_Homo sapiens_hsa047301.60660384
26Renin secretion_Homo sapiens_hsa049241.56650793
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53727412
28Cholinergic synapse_Homo sapiens_hsa047251.53688473
29Folate biosynthesis_Homo sapiens_hsa007901.50564943
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.47307266
31Taste transduction_Homo sapiens_hsa047421.45783523
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45342208
33Fatty acid biosynthesis_Homo sapiens_hsa000611.45205010
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44960068
35Cocaine addiction_Homo sapiens_hsa050301.43600652
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43092017
37Pyruvate metabolism_Homo sapiens_hsa006201.37429731
38Arginine and proline metabolism_Homo sapiens_hsa003301.35490483
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33253360
40Vibrio cholerae infection_Homo sapiens_hsa051101.31051843
41GnRH signaling pathway_Homo sapiens_hsa049121.27647664
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27046475
43Circadian rhythm_Homo sapiens_hsa047101.26822191
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24664465
45Biosynthesis of amino acids_Homo sapiens_hsa012301.24510141
46Phenylalanine metabolism_Homo sapiens_hsa003601.20348462
47Oxytocin signaling pathway_Homo sapiens_hsa049211.18449321
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15780028
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14853996
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13798329
51Axon guidance_Homo sapiens_hsa043601.11151260
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10693143
53Caffeine metabolism_Homo sapiens_hsa002321.10661484
54Pancreatic secretion_Homo sapiens_hsa049721.10095543
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06419222
56Protein digestion and absorption_Homo sapiens_hsa049741.06317860
57Dorso-ventral axis formation_Homo sapiens_hsa043201.06022043
58Mineral absorption_Homo sapiens_hsa049781.05830994
59Butanoate metabolism_Homo sapiens_hsa006501.05650246
60Gap junction_Homo sapiens_hsa045401.04238903
61Calcium signaling pathway_Homo sapiens_hsa040201.03904530
62Bile secretion_Homo sapiens_hsa049761.02584666
63Vitamin digestion and absorption_Homo sapiens_hsa049771.01788280
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01217754
65Sulfur metabolism_Homo sapiens_hsa009201.00124757
66Carbon metabolism_Homo sapiens_hsa012000.96217152
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94550198
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93359032
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90921706
70Steroid biosynthesis_Homo sapiens_hsa001000.90803147
71Estrogen signaling pathway_Homo sapiens_hsa049150.89868386
72ErbB signaling pathway_Homo sapiens_hsa040120.89385510
73cAMP signaling pathway_Homo sapiens_hsa040240.87537496
74N-Glycan biosynthesis_Homo sapiens_hsa005100.84398462
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.83367328
76Retinol metabolism_Homo sapiens_hsa008300.83152873
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82836426
78Type II diabetes mellitus_Homo sapiens_hsa049300.82246980
79Propanoate metabolism_Homo sapiens_hsa006400.81775269
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80989144
81Oxidative phosphorylation_Homo sapiens_hsa001900.80809264
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.80257555
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79935779
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79329257
85Thyroid hormone synthesis_Homo sapiens_hsa049180.79097657
86Alzheimers disease_Homo sapiens_hsa050100.78903335
87Melanogenesis_Homo sapiens_hsa049160.78421025
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77865971
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77864194
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77496621
91Tight junction_Homo sapiens_hsa045300.76856573
92Fatty acid metabolism_Homo sapiens_hsa012120.75105477
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73811558
94Glioma_Homo sapiens_hsa052140.72657140
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72134380
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70534839
97Huntingtons disease_Homo sapiens_hsa050160.69561160
98Galactose metabolism_Homo sapiens_hsa000520.68660638
99Fatty acid degradation_Homo sapiens_hsa000710.67576679
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.67029732
101Fructose and mannose metabolism_Homo sapiens_hsa000510.66154467
102Cardiac muscle contraction_Homo sapiens_hsa042600.65729938
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65565984
104Fatty acid elongation_Homo sapiens_hsa000620.65370804
105ECM-receptor interaction_Homo sapiens_hsa045120.64362743
106Choline metabolism in cancer_Homo sapiens_hsa052310.63739381
107Chemical carcinogenesis_Homo sapiens_hsa052040.63328289
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62952940
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.62669240
110Ether lipid metabolism_Homo sapiens_hsa005650.62564689
111Renin-angiotensin system_Homo sapiens_hsa046140.61759640
112VEGF signaling pathway_Homo sapiens_hsa043700.60394384
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60347693
114Sphingolipid metabolism_Homo sapiens_hsa006000.60347200
115Starch and sucrose metabolism_Homo sapiens_hsa005000.60148664
116African trypanosomiasis_Homo sapiens_hsa051430.59426666
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58779931
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58223748
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57154454
120Arginine biosynthesis_Homo sapiens_hsa002200.56945499
121Nucleotide excision repair_Homo sapiens_hsa034200.56723133
122Hippo signaling pathway_Homo sapiens_hsa043900.56403730
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.56110473
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56014853
125Histidine metabolism_Homo sapiens_hsa003400.54671936
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52311042
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51944506
128Ras signaling pathway_Homo sapiens_hsa040140.50539715
129Renal cell carcinoma_Homo sapiens_hsa052110.49919761
130Tyrosine metabolism_Homo sapiens_hsa003500.49221339
131Metabolic pathways_Homo sapiens_hsa011000.48508899
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48215790
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.47822047
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47613188
135p53 signaling pathway_Homo sapiens_hsa041150.47541350
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.47187810
137Prion diseases_Homo sapiens_hsa050200.46663822
138Fat digestion and absorption_Homo sapiens_hsa049750.45726520
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.45667672
140Inositol phosphate metabolism_Homo sapiens_hsa005620.44847175
141Parkinsons disease_Homo sapiens_hsa050120.44125795
142Phototransduction_Homo sapiens_hsa047440.43024071
143RNA polymerase_Homo sapiens_hsa030200.41533806
144Glucagon signaling pathway_Homo sapiens_hsa049220.40933710
145MAPK signaling pathway_Homo sapiens_hsa040100.40928910
146Salmonella infection_Homo sapiens_hsa051320.40411444
147Rheumatoid arthritis_Homo sapiens_hsa053230.40341521
148Endocytosis_Homo sapiens_hsa041440.39408407
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38263725
150Rap1 signaling pathway_Homo sapiens_hsa040150.36613649
151Ovarian steroidogenesis_Homo sapiens_hsa049130.36494276
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34887798
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34033163
154Oocyte meiosis_Homo sapiens_hsa041140.30285649
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.29958990

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