NDRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)7.95083827
2desmosome organization (GO:0002934)7.63435290
3drug transmembrane transport (GO:0006855)6.39558885
4hemidesmosome assembly (GO:0031581)6.25529090
5central nervous system myelination (GO:0022010)6.17821200
6axon ensheathment in central nervous system (GO:0032291)6.17821200
7aminoglycoside antibiotic metabolic process (GO:0030647)5.79122632
8establishment of skin barrier (GO:0061436)5.75383386
9urate metabolic process (GO:0046415)5.59607219
10response to mercury ion (GO:0046689)5.40889866
11regulation of water loss via skin (GO:0033561)5.40588071
12drug transport (GO:0015893)5.21790124
13phosphate ion transport (GO:0006817)4.95410164
14organic cation transport (GO:0015695)4.88248901
15bundle of His cell to Purkinje myocyte communication (GO:0086069)4.70884839
16surfactant homeostasis (GO:0043129)4.49360457
17nonribosomal peptide biosynthetic process (GO:0019184)4.35023510
18keratinocyte differentiation (GO:0030216)4.25130413
19excretion (GO:0007588)4.23150535
20quaternary ammonium group transport (GO:0015697)4.16045912
21peptide cross-linking (GO:0018149)4.15962374
22lysine catabolic process (GO:0006554)4.11630860
23lysine metabolic process (GO:0006553)4.11630860
24glutathione biosynthetic process (GO:0006750)4.09405940
25endothelial cell chemotaxis (GO:0035767)4.05346200
26multicellular organismal water homeostasis (GO:0050891)4.04885588
27phosphate ion transmembrane transport (GO:0035435)3.99326685
28metanephric tubule development (GO:0072170)3.95006767
29metanephric nephron tubule development (GO:0072234)3.95006767
30skin morphogenesis (GO:0043589)3.92558277
31keratinocyte proliferation (GO:0043616)3.89973823
32L-phenylalanine catabolic process (GO:0006559)3.86303510
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.86303510
34creatine metabolic process (GO:0006600)3.81249855
35aspartate family amino acid catabolic process (GO:0009068)3.73270917
36glyoxylate metabolic process (GO:0046487)3.71515168
37vitamin D metabolic process (GO:0042359)3.69580601
38metanephric nephron epithelium development (GO:0072243)3.69469187
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.69361505
40L-phenylalanine metabolic process (GO:0006558)3.69361505
41short-chain fatty acid metabolic process (GO:0046459)3.67767904
42regulation of cholesterol homeostasis (GO:2000188)3.67684935
43chemical homeostasis within a tissue (GO:0048875)3.63179127
44peptide biosynthetic process (GO:0043043)3.62677549
45phosphate ion homeostasis (GO:0055062)3.61048700
46trivalent inorganic anion homeostasis (GO:0072506)3.61048700
47renal absorption (GO:0070293)3.59422744
48peptidyl-proline hydroxylation (GO:0019511)3.58036620
49ensheathment of neurons (GO:0007272)3.53320574
50axon ensheathment (GO:0008366)3.53320574
51fatty acid elongation (GO:0030497)3.52729485
52polyol transport (GO:0015791)3.51075463
53intermediate filament organization (GO:0045109)3.50116188
54cytoskeletal anchoring at plasma membrane (GO:0007016)3.48992840
55protein localization to endosome (GO:0036010)3.47504991
56water homeostasis (GO:0030104)3.43999110
57hair cycle (GO:0042633)3.43005614
58molting cycle (GO:0042303)3.43005614
59myelination (GO:0042552)3.40761239
60drug catabolic process (GO:0042737)3.39223507
61cell-substrate junction assembly (GO:0007044)3.38605741
62metanephric epithelium development (GO:0072207)3.36020760
63cysteine metabolic process (GO:0006534)3.33302176
64epidermal cell differentiation (GO:0009913)3.30355865
65toxin transport (GO:1901998)3.27534085
66tricarboxylic acid metabolic process (GO:0072350)3.26600194
67exogenous drug catabolic process (GO:0042738)3.26281999
68* myelin maintenance (GO:0043217)3.24429575
69maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22473714
70response to lead ion (GO:0010288)3.16915565
71positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.16353456
72COPI coating of Golgi vesicle (GO:0048205)3.13111099
73Golgi transport vesicle coating (GO:0048200)3.13111099
74peptidyl-tyrosine autophosphorylation (GO:0038083)3.12960949
75nephron tubule development (GO:0072080)3.08779265
76photoreceptor cell differentiation (GO:0046530)3.06696177
77eye photoreceptor cell differentiation (GO:0001754)3.06696177
78branched-chain amino acid metabolic process (GO:0009081)3.05549731
79positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.04578580
80epidermis development (GO:0008544)3.04180891
81protein retention in ER lumen (GO:0006621)3.02464812
82protein hydroxylation (GO:0018126)2.98401496
83sodium-independent organic anion transport (GO:0043252)2.93426138
84modified amino acid transport (GO:0072337)2.92201430
854-hydroxyproline metabolic process (GO:0019471)2.90899314
86response to methylmercury (GO:0051597)2.86814850
87carnitine transport (GO:0015879)2.84393808
88amino-acid betaine transport (GO:0015838)2.84393808
89glucose 6-phosphate metabolic process (GO:0051156)2.84310374
90positive regulation of epidermal cell differentiation (GO:0045606)2.84262955
91calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.82642151
92response to phenylpropanoid (GO:0080184)2.81649228
93glutathione derivative biosynthetic process (GO:1901687)2.80752036
94glutathione derivative metabolic process (GO:1901685)2.80752036
95very long-chain fatty acid metabolic process (GO:0000038)2.80640079
96neuron remodeling (GO:0016322)2.79139474
97detection of bacterium (GO:0016045)2.76947941
98cellular response to vitamin D (GO:0071305)2.76183794
99epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75735130
100glycoside metabolic process (GO:0016137)2.74221513
101gap junction assembly (GO:0016264)2.73528334
102renal tubule development (GO:0061326)2.72066755
103aromatic amino acid family catabolic process (GO:0009074)2.72022974
104glutathione metabolic process (GO:0006749)2.69859019
105acetyl-CoA metabolic process (GO:0006084)2.67710694
106hypotonic response (GO:0006971)2.66142009
107cellular modified amino acid catabolic process (GO:0042219)2.62775533
108positive regulation of p38MAPK cascade (GO:1900745)2.61506391
109negative regulation of keratinocyte proliferation (GO:0010839)2.60632463
110positive regulation of epidermis development (GO:0045684)2.60219034
111positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59481801
112nephron epithelium development (GO:0072009)2.57166345
113detection of other organism (GO:0098543)2.55873028
114import into cell (GO:0098657)2.54959469
115fatty acid beta-oxidation (GO:0006635)2.53494370
116sodium ion transport (GO:0006814)2.53359623
117branched-chain amino acid catabolic process (GO:0009083)2.52031155
118regulation of early endosome to late endosome transport (GO:2000641)2.50772658
119regulation of extracellular matrix disassembly (GO:0010715)2.49571595
120barbed-end actin filament capping (GO:0051016)2.49304518
121long-chain fatty acid biosynthetic process (GO:0042759)2.48771763
122dopamine biosynthetic process (GO:0042416)2.48435942
123L-amino acid import (GO:0043092)2.47577175
124epithelial cell-cell adhesion (GO:0090136)2.46479000
125angiotensin maturation (GO:0002003)2.46437034
126sodium ion export (GO:0071436)2.45903433
127cellular potassium ion homeostasis (GO:0030007)2.45845341
128valine metabolic process (GO:0006573)2.44924647
129low-density lipoprotein particle clearance (GO:0034383)2.43894104
130proline metabolic process (GO:0006560)2.42883412
131regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.42560001
132magnesium ion transport (GO:0015693)2.41419497
133regulation of p38MAPK cascade (GO:1900744)2.40159746
134fructose metabolic process (GO:0006000)2.37494724
135cell adhesion mediated by integrin (GO:0033627)2.36320350
136nephron tubule formation (GO:0072079)2.35979066
137fatty acid oxidation (GO:0019395)2.35529509
138negative regulation of fatty acid transport (GO:2000192)2.35261534
139potassium ion import (GO:0010107)2.35261342
140intermediate filament cytoskeleton organization (GO:0045104)2.35243344
141regulation of lipoprotein metabolic process (GO:0050746)2.34959255
142positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.34161977
143very-low-density lipoprotein particle assembly (GO:0034379)2.33865409
144amyloid precursor protein metabolic process (GO:0042982)2.33725588
145response to growth hormone (GO:0060416)2.33722575
146adhesion of symbiont to host (GO:0044406)2.33462373
147negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.33006511
148cobalamin metabolic process (GO:0009235)2.32755844
149retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32671073
150glycine transport (GO:0015816)2.32479986
151apical protein localization (GO:0045176)2.32435033
152heme transport (GO:0015886)2.32379158
153linoleic acid metabolic process (GO:0043651)2.31726053
154lipoxygenase pathway (GO:0019372)2.31689579
155negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.30343902
156oligosaccharide catabolic process (GO:0009313)2.30336043
157regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.30234430
158lipid oxidation (GO:0034440)2.30199465
159response to lipoprotein particle (GO:0055094)2.28874790
160glutamate metabolic process (GO:0006536)2.28710688
161fatty acid catabolic process (GO:0009062)2.28607002
162negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.28439680
163cellular response to vitamin (GO:0071295)2.27713900
164pinocytosis (GO:0006907)2.26076279
165basement membrane organization (GO:0071711)2.25293549
166regulation of membrane protein ectodomain proteolysis (GO:0051043)2.24078585
167positive regulation of Cdc42 GTPase activity (GO:0043089)2.23506343
168semaphorin-plexin signaling pathway (GO:0071526)2.23285731
169regulation of transforming growth factor beta1 production (GO:0032908)2.22743347
170intermediate filament-based process (GO:0045103)2.21587865
171regulation of endothelial cell chemotaxis (GO:2001026)2.19282505
172cell-cell junction maintenance (GO:0045217)2.18493278
173positive regulation of keratinocyte differentiation (GO:0045618)2.17639354
174response to laminar fluid shear stress (GO:0034616)2.17388049
175cell volume homeostasis (GO:0006884)2.15409997
176regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.14797804
177regulation of cholesterol biosynthetic process (GO:0045540)2.13628030
178embryonic process involved in female pregnancy (GO:0060136)2.12566315
179endocytic recycling (GO:0032456)2.10704280
180vascular endothelial growth factor signaling pathway (GO:0038084)2.10446190
181activation of Rac GTPase activity (GO:0032863)2.10060707
182protein-lipid complex assembly (GO:0065005)2.09790567
183virion attachment to host cell (GO:0019062)2.09395289
184adhesion of symbiont to host cell (GO:0044650)2.09395289
185cell communication involved in cardiac conduction (GO:0086065)2.09182082
186regulation of keratinocyte differentiation (GO:0045616)2.06305721
187renal filtration (GO:0097205)2.05664673
188activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.05050265
189vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.04523947
190regulation of extracellular matrix organization (GO:1903053)2.03364947
191cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.03269564
192lung vasculature development (GO:0060426)2.01822154
193positive regulation of steroid biosynthetic process (GO:0010893)2.00446823
194focal adhesion assembly (GO:0048041)1.99546792
195cell-substrate adherens junction assembly (GO:0007045)1.99546792
196positive regulation of extracellular matrix organization (GO:1903055)1.99509883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.66254045
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48084190
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.42325808
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31692871
5* ESR2_21235772_ChIP-Seq_MCF-7_Human2.26993482
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.06886215
7CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97149091
8* ESR1_21235772_ChIP-Seq_MCF-7_Human1.94628354
9* ELK3_25401928_ChIP-Seq_HUVEC_Human1.89000238
10ZNF263_19887448_ChIP-Seq_K562_Human1.78419728
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77126948
12KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75553453
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75533697
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75265810
15KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.73514318
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71424552
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70911699
18RXR_22158963_ChIP-Seq_LIVER_Mouse1.68051774
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65207048
20* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64780050
21* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64780050
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64768637
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63792947
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63264134
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58109431
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53262822
27* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53137786
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52599395
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52599395
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52413893
31* LXR_22158963_ChIP-Seq_LIVER_Mouse1.48702015
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48042120
33VDR_22108803_ChIP-Seq_LS180_Human1.47882756
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.45469217
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44660041
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43968663
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43467553
38* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43396078
39* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42246006
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.42137576
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41731965
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.41610909
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40614653
44* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38988070
45* ATF3_27146783_Chip-Seq_COLON_Human1.38618409
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.37366626
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35994701
48AR_21572438_ChIP-Seq_LNCaP_Human1.35771316
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.35371177
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33684512
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33301865
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32514885
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32015260
54GBX2_23144817_ChIP-Seq_PC3_Human1.31080699
55* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30229956
56* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28917743
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27836529
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27734203
59CLOCK_20551151_ChIP-Seq_293T_Human1.27040706
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26078646
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25840533
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.25741889
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.25714459
64KDM2B_26808549_Chip-Seq_DND41_Human1.24926884
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.23173290
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.22912264
67DROSHA_22980978_ChIP-Seq_HELA_Human1.22735169
68SOX2_20726797_ChIP-Seq_SW620_Human1.20253988
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.19901088
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19324191
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19324191
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17907784
73TP63_22573176_ChIP-Seq_HFKS_Human1.17743972
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.15698391
75* SMC4_20622854_ChIP-Seq_HELA_Human1.15423794
76EGR1_19032775_ChIP-ChIP_M12_Human1.14629308
77* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14313224
78* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13896529
79* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13392521
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12800061
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10784509
82AHR_22903824_ChIP-Seq_MCF-7_Human1.10124479
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.09902337
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08499116
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08368940
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08098226
87CREB1_26743006_Chip-Seq_LNCaP_Human1.07749785
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07730498
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06982248
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.05844138
91VDR_21846776_ChIP-Seq_THP-1_Human1.05375735
92GATA6_25053715_ChIP-Seq_YYC3_Human1.05153847
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05151098
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.04657389
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03277824
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03035717
97* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02283799
98* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02144646
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01036649
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00765392
101GATA1_19941826_ChIP-Seq_K562_Human0.99749786
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.99571494
103* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98845965
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.97979041
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97142122
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96652535
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95996088
108P68_20966046_ChIP-Seq_HELA_Human0.94592833
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94424009
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94311912
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.94115304
112P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93959203
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93389976
114* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93190850
115KDM2B_26808549_Chip-Seq_JURKAT_Human0.93044008
116RACK7_27058665_Chip-Seq_MCF-7_Human0.92776743
117GATA4_25053715_ChIP-Seq_YYC3_Human0.92188815
118RXR_22108803_ChIP-Seq_LS180_Human0.91660960
119EOMES_21245162_ChIP-Seq_HESCs_Human0.90649368
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.90620581
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.90620581
122CJUN_26792858_Chip-Seq_BT549_Human0.90365491
123* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90323080
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90270219
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.89232443
126* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88905663
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88647187
128* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88197828
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87120360
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87019047
131* TP63_23658742_ChIP-Seq_EP156T_Human0.86948185
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86771969
133MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86734628
134* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86678580
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86662151
136CTCF_27219007_Chip-Seq_Bcells_Human0.86384145
137KDM2B_26808549_Chip-Seq_K562_Human0.86254754
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86117571
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85816419
140TP53_22127205_ChIP-Seq_IMR90_Human0.85762372
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84257594
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83872589
143CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83069577
144SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83042175
145* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82962561
146* RNF2_27304074_Chip-Seq_ESCs_Mouse0.82889659
147* ERG_21242973_ChIP-ChIP_JURKAT_Human0.81906909
148LXR_22292898_ChIP-Seq_THP-1_Human0.81309367
149CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80590736
150* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80215369
151EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77742134
152* KLF5_25053715_ChIP-Seq_YYC3_Human0.76353222
153SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76294641
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75248888
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.74915592
156* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74250702
157TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74144751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation6.10145591
2MP0005360_urolithiasis4.51053746
3MP0000579_abnormal_nail_morphology4.08456905
4MP0003195_calcinosis4.06012282
5MP0004019_abnormal_vitamin_homeostasis3.58371180
6MP0005275_abnormal_skin_tensile3.58169221
7MP0001765_abnormal_ion_homeostasis3.41403846
8MP0005332_abnormal_amino_acid3.38757342
9MP0004885_abnormal_endolymph3.12957761
10MP0003705_abnormal_hypodermis_morpholog3.10860937
11MP0003566_abnormal_cell_adhesion3.07532624
12* MP0000920_abnormal_myelination3.05514455
13MP0003453_abnormal_keratinocyte_physiol3.03726667
14MP0009643_abnormal_urine_homeostasis2.96035272
15MP0001756_abnormal_urination2.46621672
16MP0005636_abnormal_mineral_homeostasis2.37356266
17MP0001216_abnormal_epidermal_layer2.37096788
18MP0002138_abnormal_hepatobiliary_system2.32050145
19MP0005058_abnormal_lysosome_morphology2.31193196
20MP0004264_abnormal_extraembryonic_tissu2.30139447
21MP0000467_abnormal_esophagus_morphology2.28312184
22MP0002060_abnormal_skin_morphology2.26075116
23MP0001958_emphysema2.24983090
24MP0003329_amyloid_beta_deposits2.15448211
25MP0008438_abnormal_cutaneous_collagen2.14890062
26MP0005023_abnormal_wound_healing2.12704013
27MP0002136_abnormal_kidney_physiology2.08178319
28MP0002139_abnormal_hepatobiliary_system2.06799523
29MP0000566_synostosis1.93269875
30MP0003950_abnormal_plasma_membrane1.92698921
31MP0004947_skin_inflammation1.90868921
32MP0005377_hearing/vestibular/ear_phenot1.84937712
33MP0003878_abnormal_ear_physiology1.84937712
34MP0000678_abnormal_parathyroid_gland1.81296707
35MP0003690_abnormal_glial_cell1.80315147
36MP0003941_abnormal_skin_development1.70509957
37MP0010771_integument_phenotype1.70312064
38MP0010352_gastrointestinal_tract_polyps1.65681474
39MP0003300_gastrointestinal_ulcer1.65439258
40MP0004742_abnormal_vestibular_system1.64929752
41MP0004782_abnormal_surfactant_physiolog1.64814145
42MP0004270_analgesia1.58879238
43MP0003634_abnormal_glial_cell1.51975024
44MP0004381_abnormal_hair_follicle1.49279992
45MP0004185_abnormal_adipocyte_glucose1.39092783
46MP0005076_abnormal_cell_differentiation1.37369562
47MP0000747_muscle_weakness1.36370299
48MP0000377_abnormal_hair_follicle1.34745999
49MP0008875_abnormal_xenobiotic_pharmacok1.32252272
50MP0005551_abnormal_eye_electrophysiolog1.27850194
51MP0005257_abnormal_intraocular_pressure1.26080617
52MP0005584_abnormal_enzyme/coenzyme_acti1.25078839
53MP0000230_abnormal_systemic_arterial1.24933869
54MP0002229_neurodegeneration1.24737239
55MP0008961_abnormal_basal_metabolism1.23364813
56MP0001851_eye_inflammation1.22267300
57MP0002796_impaired_skin_barrier1.21800079
58MP0004272_abnormal_basement_membrane1.21350327
59MP0009931_abnormal_skin_appearance1.21237499
60MP0004147_increased_porphyrin_level1.20576931
61MP0000538_abnormal_urinary_bladder1.16570853
62MP0004510_myositis1.16219900
63MP0003879_abnormal_hair_cell1.15832251
64MP0002896_abnormal_bone_mineralization1.15689432
65MP0003091_abnormal_cell_migration1.15195848
66MP0003252_abnormal_bile_duct1.14836443
67MP0001485_abnormal_pinna_reflex1.14090190
68MP0000604_amyloidosis1.13890046
69MP0000013_abnormal_adipose_tissue1.12462410
70MP0001849_ear_inflammation1.11810089
71MP0002877_abnormal_melanocyte_morpholog1.11771750
72MP0003315_abnormal_perineum_morphology1.09875689
73MP0005451_abnormal_body_composition1.08919625
74MP0010678_abnormal_skin_adnexa1.08776041
75MP0003186_abnormal_redox_activity1.07447638
76MP0002168_other_aberrant_phenotype1.05177567
77MP0003283_abnormal_digestive_organ1.04411091
78MP0009053_abnormal_anal_canal1.03545075
79MP0002272_abnormal_nervous_system1.01136894
80MP0010234_abnormal_vibrissa_follicle1.00424363
81MP0009379_abnormal_foot_pigmentation0.98752306
82MP0005375_adipose_tissue_phenotype0.97302713
83MP0000003_abnormal_adipose_tissue0.96834394
84MP0003436_decreased_susceptibility_to0.96364866
85MP0001666_abnormal_nutrient_absorption0.95404398
86MP0005171_absent_coat_pigmentation0.95273419
87MP0000462_abnormal_digestive_system0.94107786
88MP0003183_abnormal_peptide_metabolism0.94011555
89MP0002118_abnormal_lipid_homeostasis0.93783673
90MP0005084_abnormal_gallbladder_morpholo0.91960329
91MP0004858_abnormal_nervous_system0.89377599
92MP0009780_abnormal_chondrocyte_physiolo0.87788693
93MP0005666_abnormal_adipose_tissue0.87482516
94MP0002064_seizures0.85519359
95MP0005365_abnormal_bile_salt0.84977510
96* MP0003633_abnormal_nervous_system0.84814946
97MP0002166_altered_tumor_susceptibility0.83371272
98MP0001661_extended_life_span0.82986262
99MP0000858_altered_metastatic_potential0.82132241
100MP0000367_abnormal_coat/_hair0.82032886
101MP0005166_decreased_susceptibility_to0.81602778
102MP0003632_abnormal_nervous_system0.81242118
103MP0001486_abnormal_startle_reflex0.81021621
104MP0005535_abnormal_body_temperature0.80877695
105MP0009840_abnormal_foam_cell0.79080398
106MP0003959_abnormal_lean_body0.78720925
107MP0005501_abnormal_skin_physiology0.77522529
108MP0003191_abnormal_cellular_cholesterol0.77433974
109MP0005408_hypopigmentation0.77239296
110* MP0003631_nervous_system_phenotype0.77238288
111MP0005165_increased_susceptibility_to0.77005887
112MP0000537_abnormal_urethra_morphology0.76742710
113MP0004142_abnormal_muscle_tone0.76228471
114MP0001664_abnormal_digestion0.75285852
115MP0001191_abnormal_skin_condition0.75018349
116MP0002734_abnormal_mechanical_nocicepti0.74739189
117MP0002234_abnormal_pharynx_morphology0.74696098
118MP0002006_tumorigenesis0.74555120
119MP0002089_abnormal_postnatal_growth/wei0.74121129
120MP0003011_delayed_dark_adaptation0.73903754
121MP0003172_abnormal_lysosome_physiology0.73464535
122MP0001963_abnormal_hearing_physiology0.72838381
123MP0008260_abnormal_autophagy0.72505340
124MP0003303_peritoneal_inflammation0.72119017
125MP0003045_fibrosis0.71471663
126MP0010155_abnormal_intestine_physiology0.71024211
127MP0005164_abnormal_response_to0.70739673
128MP0003075_altered_response_to0.69229727
129MP0000762_abnormal_tongue_morphology0.69199379
130MP0000627_abnormal_mammary_gland0.67784723
131MP0003638_abnormal_response/metabolism_0.66496824
132MP0002295_abnormal_pulmonary_circulatio0.65640263
133MP0005195_abnormal_posterior_eye0.65579847
134MP0006072_abnormal_retinal_apoptosis0.64812315
135MP0000778_abnormal_nervous_system0.64470107
136MP0005085_abnormal_gallbladder_physiolo0.63775704
137MP0010386_abnormal_urinary_bladder0.63412799
138MP0005167_abnormal_blood-brain_barrier0.63202424
139MP0002971_abnormal_brown_adipose0.62838935
140MP0005253_abnormal_eye_physiology0.61945334
141MP0002098_abnormal_vibrissa_morphology0.61443960
142MP0001177_atelectasis0.61437617
143MP0001533_abnormal_skeleton_physiology0.61266801
144MP0001299_abnormal_eye_distance/0.60732555
145MP0005670_abnormal_white_adipose0.60264074
146MP0010329_abnormal_lipoprotein_level0.58862777
147MP0008004_abnormal_stomach_pH0.58323018
148MP0005409_darkened_coat_color0.58073969
149MP0000383_abnormal_hair_follicle0.57511302
150MP0005623_abnormal_meninges_morphology0.57117160
151MP0002998_abnormal_bone_remodeling0.56754765
152MP0005381_digestive/alimentary_phenotyp0.56141350
153MP0006138_congestive_heart_failure0.55745591
154MP0002909_abnormal_adrenal_gland0.53233089
155MP0003279_aneurysm0.52512794
156MP0010368_abnormal_lymphatic_system0.52333213
157MP0003868_abnormal_feces_composition0.52290384

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.65173175
2Abnormality of nail color (HP:0100643)7.64198245
3Metabolic alkalosis (HP:0200114)7.22817239
4Hypokalemic alkalosis (HP:0001949)7.08603372
5Hypomagnesemia (HP:0002917)6.68529393
6Hyperactive renin-angiotensin system (HP:0000841)5.78507821
7Polyuria (HP:0000103)5.70007656
8Abnormality of magnesium homeostasis (HP:0004921)5.65219858
9Abnormality of chloride homeostasis (HP:0011422)5.46838773
10Abnormal urine output (HP:0012590)5.31166457
11Thick nail (HP:0001805)5.27436755
12Gout (HP:0001997)5.23905479
13Abnormality of renal excretion (HP:0011036)5.12304647
14Palmoplantar hyperkeratosis (HP:0000972)5.07750577
15Alopecia of scalp (HP:0002293)4.92080107
16Plantar hyperkeratosis (HP:0007556)4.85404488
17Abnormal drinking behavior (HP:0030082)4.71954642
18Polydipsia (HP:0001959)4.71954642
19Palmar hyperkeratosis (HP:0010765)4.70169915
20Abnormality of renin-angiotensin system (HP:0000847)4.58998049
21Right ventricular cardiomyopathy (HP:0011663)4.53536621
22Renal salt wasting (HP:0000127)4.50620221
23Hyperaldosteronism (HP:0000859)4.33992886
24Alkalosis (HP:0001948)4.24999724
25Tetany (HP:0001281)4.18118973
26Proximal tubulopathy (HP:0000114)3.81227397
27Onycholysis (HP:0001806)3.69230536
28Milia (HP:0001056)3.67589903
29Increased purine levels (HP:0004368)3.65110487
30Hyperuricemia (HP:0002149)3.65110487
31Hypokalemia (HP:0002900)3.60971110
32Oral leukoplakia (HP:0002745)3.59684061
33Hypercalciuria (HP:0002150)3.52530886
34Increased IgE level (HP:0003212)3.30072228
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.29153613
36Abnormal blistering of the skin (HP:0008066)3.20403670
37Abnormality of purine metabolism (HP:0004352)3.17974610
38Nail dystrophy (HP:0008404)3.16649887
39Follicular hyperkeratosis (HP:0007502)3.09577448
40Abnormality of potassium homeostasis (HP:0011042)3.05078860
41Fragile nails (HP:0001808)2.99667164
42Congenital ichthyosiform erythroderma (HP:0007431)2.97013020
43Neurofibrillary tangles (HP:0002185)2.93282131
44Natal tooth (HP:0000695)2.87333783
45Erythema (HP:0010783)2.86580585
46Hyperglycinuria (HP:0003108)2.84819216
47Delayed epiphyseal ossification (HP:0002663)2.81018370
48Ketoacidosis (HP:0001993)2.80531773
49Generalized aminoaciduria (HP:0002909)2.78769891
50Atrophic scars (HP:0001075)2.78309469
51Advanced eruption of teeth (HP:0006288)2.78247977
52Hypotrichosis (HP:0001006)2.77779894
53Flat acetabular roof (HP:0003180)2.76960000
54Lip pit (HP:0100267)2.72712861
55Corneal erosion (HP:0200020)2.70991629
56Abnormality of serine family amino acid metabolism (HP:0010894)2.70306724
57Abnormality of glycine metabolism (HP:0010895)2.70306724
58Abnormality of urine glucose concentration (HP:0011016)2.63256469
59Glycosuria (HP:0003076)2.63256469
60Abnormality of proline metabolism (HP:0010907)2.62385293
61Hydroxyprolinuria (HP:0003080)2.62385293
62Abnormality of the axillary hair (HP:0100134)2.59337645
63Abnormality of secondary sexual hair (HP:0009888)2.59337645
64Renal tubular acidosis (HP:0001947)2.56574912
65Malnutrition (HP:0004395)2.54969052
66Nephrocalcinosis (HP:0000121)2.50241110
67Abnormality of the salivary glands (HP:0010286)2.47814253
68Rickets (HP:0002748)2.47021640
69Degeneration of the lateral corticospinal tracts (HP:0002314)2.40380198
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40380198
71Vascular calcification (HP:0004934)2.37171067
72Abnormal urine phosphate concentration (HP:0012599)2.37143935
73Peripheral hypomyelination (HP:0007182)2.35485684
74Protrusio acetabuli (HP:0003179)2.35471762
75Nephrolithiasis (HP:0000787)2.34148053
76Hyperphosphaturia (HP:0003109)2.34093668
77Pili torti (HP:0003777)2.33131808
78Ridged nail (HP:0001807)2.32360968
79Erythroderma (HP:0001019)2.31161469
80Laryngomalacia (HP:0001601)2.31007614
81Woolly hair (HP:0002224)2.29166615
82Broad face (HP:0000283)2.28703437
83Hypophosphatemia (HP:0002148)2.27898869
84Vacuolated lymphocytes (HP:0001922)2.26311974
85Deep venous thrombosis (HP:0002625)2.25155269
86Ketosis (HP:0001946)2.24069202
87Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23349425
88Palmoplantar keratoderma (HP:0000982)2.20968716
89Cerebral inclusion bodies (HP:0100314)2.20455258
90Abnormal hair laboratory examination (HP:0003328)2.17606305
91Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17227043
92Dehydration (HP:0001944)2.17050032
93Adrenal overactivity (HP:0002717)2.16413471
94Abnormality of carpal bone ossification (HP:0006257)2.13427032
95Confusion (HP:0001289)2.11922671
96* Onion bulb formation (HP:0003383)2.11810493
97Cardiovascular calcification (HP:0011915)2.11635685
98Cerebral aneurysm (HP:0004944)2.11155437
99Vertebral compression fractures (HP:0002953)2.10569317
100Muscle fiber splitting (HP:0003555)2.10011966
101Systemic lupus erythematosus (HP:0002725)2.09788309
102Hypoplasia of the iris (HP:0007676)2.08686687
103Widely patent fontanelles and sutures (HP:0004492)2.08425636
104Neonatal death (HP:0003811)2.07244594
105Enlarged epiphyses (HP:0010580)2.06223393
106Abnormality of sodium homeostasis (HP:0010931)2.05284676
107Premature rupture of membranes (HP:0001788)2.04957464
108Termporal pattern (HP:0011008)2.04162465
109Insidious onset (HP:0003587)2.04162465
110Thin bony cortex (HP:0002753)2.02943600
111Stridor (HP:0010307)2.00046418
112Glomerulosclerosis (HP:0000096)1.99397201
113Abnormality of the Achilles tendon (HP:0005109)1.99310384
114Achilles tendon contracture (HP:0001771)1.98654525
115Abnormal enzyme/coenzyme activity (HP:0012379)1.97023550
116Hyperparathyroidism (HP:0000843)1.96729072
117Abnormality of alkaline phosphatase activity (HP:0004379)1.94771740
118Fragile skin (HP:0001030)1.93922779
119Obstructive sleep apnea (HP:0002870)1.92805225
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.92589332
121Osteolytic defects of the hand bones (HP:0009699)1.92589332
122* Segmental peripheral demyelination/remyelination (HP:0003481)1.91719255
123Ectropion (HP:0000656)1.91592227
124Abnormality of renal resorption (HP:0011038)1.91031583
125Abnormality of fatty-acid metabolism (HP:0004359)1.90804530
126Metaphyseal cupping (HP:0003021)1.89658393
127Parakeratosis (HP:0001036)1.89491586
128Interstitial pulmonary disease (HP:0006530)1.89383270
129Abnormality of the distal phalanges of the toes (HP:0010182)1.89119641
130Hypophosphatemic rickets (HP:0004912)1.88907671
131Cervical subluxation (HP:0003308)1.88618966
132Abnormal ossification of hand bones (HP:0005921)1.88355515
133Abnormal tarsal ossification (HP:0008369)1.88283765
134Abnormality of nucleobase metabolism (HP:0010932)1.88112147
135Ankyloglossia (HP:0010296)1.87868797
136Amyloidosis (HP:0011034)1.87589781
137Abnormality of complement system (HP:0005339)1.86351111
138Hyponatremia (HP:0002902)1.85522252
139Abnormality of calcium-phosphate metabolism (HP:0100530)1.85503390
140Dysostosis multiplex (HP:0000943)1.84532778
141Hypohidrosis (HP:0000966)1.84151254
142Abnormality of the costochondral junction (HP:0000919)1.83392342
143Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82919107
144Protuberant abdomen (HP:0001538)1.81196057
145Absent eyelashes (HP:0000561)1.80385865
146Gangrene (HP:0100758)1.80068749
147Complement deficiency (HP:0004431)1.77947760
148Short nail (HP:0001799)1.77104136
149Supranuclear gaze palsy (HP:0000605)1.77043394
150Hypoplasia of dental enamel (HP:0006297)1.76165329
151Distal lower limb amyotrophy (HP:0008944)1.76044694
152Sparse scalp hair (HP:0002209)1.75678154
153Decreased circulating renin level (HP:0003351)1.74321405
154Diaphragmatic weakness (HP:0009113)1.74204760
155Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72588171
156Abnormality of the corticospinal tract (HP:0002492)1.71677895
157Hyperhidrosis (HP:0000975)1.71481841
158Anonychia (HP:0001798)1.71431294
159Shallow orbits (HP:0000586)1.71244445
160Potter facies (HP:0002009)1.70938500
161Facial shape deformation (HP:0011334)1.70938500
162Abnormality of the distal phalanx of the thumb (HP:0009617)1.70937959
163Bronchomalacia (HP:0002780)1.70927197
164Elevated alkaline phosphatase (HP:0003155)1.69819585
165Hemorrhage of the eye (HP:0011885)1.69687591
166Popliteal pterygium (HP:0009756)1.68617763
167Sparse eyelashes (HP:0000653)1.67703980
168Metaphyseal irregularity (HP:0003025)1.66422419
169Increased connective tissue (HP:0009025)1.65672943
170Polygenic inheritance (HP:0010982)1.65182552
171Methylmalonic aciduria (HP:0012120)1.65038504
172Congenital sensorineural hearing impairment (HP:0008527)1.65032009
173Acanthosis nigricans (HP:0000956)1.64764251
174Glomerulonephritis (HP:0000099)1.64512748
175Wormian bones (HP:0002645)1.63319414
176Ventricular tachycardia (HP:0004756)1.62887124
177Arterial tortuosity (HP:0005116)1.62735638
178Distal lower limb muscle weakness (HP:0009053)1.62027101
179Renal tubular dysfunction (HP:0000124)1.60884087
180Multifactorial inheritance (HP:0001426)1.60645031
181Irritability (HP:0000737)1.59525013
182Tubular atrophy (HP:0000092)1.59459852
183Abnormal hand bone ossification (HP:0010660)1.59349055
184Ileus (HP:0002595)1.59300244
185Abolished electroretinogram (ERG) (HP:0000550)1.58969708
186Hyperkalemia (HP:0002153)1.58892390
187Focal segmental glomerulosclerosis (HP:0000097)1.58377170
188Pterygium (HP:0001059)1.56975579
189Blepharitis (HP:0000498)1.56300089
190Xanthomatosis (HP:0000991)1.56105300
191Nuclear cataract (HP:0100018)1.55845156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.55717546
2OXSR16.64622975
3STK396.17298541
4WNK35.18612324
5ERN13.72236061
6RIPK13.45502238
7EPHB13.17628049
8TRIB32.92160159
9WNK12.50562919
10PRPF4B2.42506203
11IRAK32.34969861
12TAOK12.02378316
13ARAF1.99432734
14SIK11.99322005
15ICK1.96993678
16PDGFRA1.89052240
17MAPKAPK51.66788073
18LATS21.63699960
19MET1.63366351
20EEF2K1.61742425
21MAP3K91.57951512
22TESK11.56255989
23PKN11.51773574
24MAP3K61.50286405
25BCKDK1.49673517
26CDK121.49430534
27NTRK11.43235761
28LMTK21.37840972
29SMG11.33859062
30MST41.28018591
31INSRR1.25845248
32PIM21.24455645
33MAPK151.23733678
34FGFR31.21104784
35CDC42BPA1.14345409
36LIMK11.12659642
37PKN21.09778219
38MAP3K21.08992882
39MAPKAPK31.04412704
40PDK21.04140163
41PBK1.02540321
42EPHB21.01646866
43FGFR21.01592197
44MAP2K21.00117735
45STK240.99623369
46BCR0.98170412
47PRKD30.97752126
48PINK10.95714951
49MAP2K60.92145417
50* SGK2230.90338197
51* SGK4940.90338197
52LATS10.89797967
53MST1R0.88920517
54UHMK10.88828918
55MTOR0.88292202
56CAMK2B0.88180889
57NME20.87876063
58IRAK20.87723110
59TGFBR20.86688088
60PAK40.84405377
61MOS0.84313408
62ROCK20.82359734
63TAOK20.79068462
64FER0.78475732
65PAK30.77090146
66KSR20.72103473
67LRRK20.71958832
68PDPK10.70233348
69PRKD10.69837254
70CAMK2D0.69604568
71PTK20.68534464
72CDK190.68532379
73CSNK1A1L0.68210743
74RIPK40.65741443
75MARK20.65227748
76STK38L0.61566071
77TTN0.61406973
78TIE10.60647569
79NEK60.59919665
80AKT30.59223994
81DDR20.56486482
82CAMK2G0.55974107
83PAK60.54937119
84CAMK1G0.54384551
85MAP3K10.53712159
86ZAP700.53670489
87MAP3K110.52562303
88PDK30.52542206
89PDK40.52542206
90FGFR40.52378949
91CSNK1G30.52267317
92STK380.50910383
93BRAF0.50861460
94RPS6KA20.50388684
95TBK10.50220225
96PRKCE0.50210835
97PRKCH0.50037604
98BMX0.49483847
99CDK50.48842065
100MAPK110.47439562
101PRKG20.47134410
102* GSK3A0.46625881
103CSNK1G10.46330163
104PAK20.46295099
105MAP3K70.45569690
106TYK20.45401991
107PTK60.45182686
108PRKD20.45084473
109EPHA30.43248674
110TESK20.43129249
111MAP3K30.43096847
112RET0.42199456
113JAK10.40487391
114DMPK0.39311905
115MAPK70.39076310
116DYRK1B0.38933655
117GRK10.38895612
118CSNK1G20.38665381
119HIPK20.38552277
120PNCK0.38499451
121SGK30.36881254
122PDK10.36770496
123STK110.35783628
124PDGFRB0.35337871
125FGFR10.35300523
126MAP2K30.35041983
127CAMK2A0.34364326
128IRAK10.33969170
129FGR0.32991213
130TRPM70.32710852
131ERBB20.32645823
132BLK0.32404330
133PRKCZ0.32227252
134PRKCQ0.32099219
135PHKG20.31991943
136PHKG10.31991943
137PTK2B0.31860107
138MUSK0.31002349
139EPHA40.30491982
140DAPK20.29691991
141TYRO30.29627503
142CSK0.29210148
143EPHA20.29179437
144FYN0.28274634
145CSNK1A10.26881095
146* SGK10.24881712
147SRC0.24343939
148PRKAA20.23143775
149INSR0.22504888
150ABL20.21923176
151MAPK120.21100845
152NME10.20846600
153CAMK1D0.20600162
154MAP3K130.20548693

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.01258649
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28018734
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.78038534
4Butanoate metabolism_Homo sapiens_hsa006502.73534165
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39770751
6Sulfur metabolism_Homo sapiens_hsa009202.35294680
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.35210383
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.32878246
9Fatty acid elongation_Homo sapiens_hsa000622.30235205
10Propanoate metabolism_Homo sapiens_hsa006402.27482363
11Collecting duct acid secretion_Homo sapiens_hsa049662.21000571
12Nitrogen metabolism_Homo sapiens_hsa009102.14675981
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.04069087
14Steroid biosynthesis_Homo sapiens_hsa001002.03952727
15Vitamin digestion and absorption_Homo sapiens_hsa049771.94367500
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93794599
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93268032
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86139291
19Fatty acid biosynthesis_Homo sapiens_hsa000611.85241454
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84002652
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68799784
22Pyruvate metabolism_Homo sapiens_hsa006201.61927337
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58457780
24Peroxisome_Homo sapiens_hsa041461.58023416
25Galactose metabolism_Homo sapiens_hsa000521.57846857
26Mineral absorption_Homo sapiens_hsa049781.56325740
27Protein digestion and absorption_Homo sapiens_hsa049741.51792635
28Arginine and proline metabolism_Homo sapiens_hsa003301.47850285
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46002945
30Histidine metabolism_Homo sapiens_hsa003401.45014338
31VEGF signaling pathway_Homo sapiens_hsa043701.40517058
32Fatty acid metabolism_Homo sapiens_hsa012121.37207701
33Bile secretion_Homo sapiens_hsa049761.34468393
34GnRH signaling pathway_Homo sapiens_hsa049121.33924365
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30952722
36Glutathione metabolism_Homo sapiens_hsa004801.29348689
37Fatty acid degradation_Homo sapiens_hsa000711.28858426
38Prion diseases_Homo sapiens_hsa050201.26428314
39beta-Alanine metabolism_Homo sapiens_hsa004101.25572489
40Fat digestion and absorption_Homo sapiens_hsa049751.22191549
41Tryptophan metabolism_Homo sapiens_hsa003801.20936727
42Amoebiasis_Homo sapiens_hsa051461.20585999
43Folate biosynthesis_Homo sapiens_hsa007901.18692522
44Lysosome_Homo sapiens_hsa041421.18188651
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16864220
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.14050372
47Bladder cancer_Homo sapiens_hsa052191.13939715
48Complement and coagulation cascades_Homo sapiens_hsa046101.09286631
49HIF-1 signaling pathway_Homo sapiens_hsa040661.08783231
50Other glycan degradation_Homo sapiens_hsa005111.06615193
51Sphingolipid metabolism_Homo sapiens_hsa006001.05523562
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.04097906
53Vibrio cholerae infection_Homo sapiens_hsa051100.99645249
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98836881
55Gastric acid secretion_Homo sapiens_hsa049710.98556611
56Focal adhesion_Homo sapiens_hsa045100.96872928
57Ether lipid metabolism_Homo sapiens_hsa005650.95804247
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93798786
59Notch signaling pathway_Homo sapiens_hsa043300.88818983
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88272850
61Proteoglycans in cancer_Homo sapiens_hsa052050.87623761
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.87541603
63Acute myeloid leukemia_Homo sapiens_hsa052210.87025887
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86913937
65Phototransduction_Homo sapiens_hsa047440.86262493
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86234938
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85941172
68Insulin signaling pathway_Homo sapiens_hsa049100.85637712
69ErbB signaling pathway_Homo sapiens_hsa040120.85145931
70Adherens junction_Homo sapiens_hsa045200.83628422
71Pertussis_Homo sapiens_hsa051330.83091594
72PPAR signaling pathway_Homo sapiens_hsa033200.83076920
73Glycerolipid metabolism_Homo sapiens_hsa005610.82216253
74Pancreatic cancer_Homo sapiens_hsa052120.81920473
75Oxidative phosphorylation_Homo sapiens_hsa001900.80674636
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80317483
77Estrogen signaling pathway_Homo sapiens_hsa049150.78923864
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78589675
79Carbon metabolism_Homo sapiens_hsa012000.77344448
80Chronic myeloid leukemia_Homo sapiens_hsa052200.77314652
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77275956
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76754745
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76563554
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76411223
85Pancreatic secretion_Homo sapiens_hsa049720.75818124
86Insulin resistance_Homo sapiens_hsa049310.75689876
87Renin secretion_Homo sapiens_hsa049240.75191684
88Synaptic vesicle cycle_Homo sapiens_hsa047210.75013780
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74860854
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.74643284
91Long-term potentiation_Homo sapiens_hsa047200.74582477
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74294013
93Pentose phosphate pathway_Homo sapiens_hsa000300.69693584
94Hepatitis C_Homo sapiens_hsa051600.69488542
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69040875
96TNF signaling pathway_Homo sapiens_hsa046680.67317327
97Glioma_Homo sapiens_hsa052140.66915482
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66537647
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66191550
100AMPK signaling pathway_Homo sapiens_hsa041520.65633395
101Glucagon signaling pathway_Homo sapiens_hsa049220.65484292
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65180685
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65135693
104Thyroid hormone synthesis_Homo sapiens_hsa049180.65095455
105Staphylococcus aureus infection_Homo sapiens_hsa051500.64397109
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63543371
107Circadian rhythm_Homo sapiens_hsa047100.63427463
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.62263176
109mTOR signaling pathway_Homo sapiens_hsa041500.61709078
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.61419133
111Toxoplasmosis_Homo sapiens_hsa051450.61017933
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60936239
113Arachidonic acid metabolism_Homo sapiens_hsa005900.60524548
114Salmonella infection_Homo sapiens_hsa051320.60330233
115Non-small cell lung cancer_Homo sapiens_hsa052230.59981504
116Starch and sucrose metabolism_Homo sapiens_hsa005000.59502414
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.58791014
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58300797
119Arginine biosynthesis_Homo sapiens_hsa002200.58100167
120Renin-angiotensin system_Homo sapiens_hsa046140.57057214
121Small cell lung cancer_Homo sapiens_hsa052220.55312820
122Phenylalanine metabolism_Homo sapiens_hsa003600.55114699
123ECM-receptor interaction_Homo sapiens_hsa045120.54631503
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.53984242
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.53884183
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53437791
127Ovarian steroidogenesis_Homo sapiens_hsa049130.53379090
128Tight junction_Homo sapiens_hsa045300.52694760
129Lysine degradation_Homo sapiens_hsa003100.52264174
130Endometrial cancer_Homo sapiens_hsa052130.52163879
131Thyroid cancer_Homo sapiens_hsa052160.51533137
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51306658
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50580360
134MicroRNAs in cancer_Homo sapiens_hsa052060.50061669
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49398177
136Rheumatoid arthritis_Homo sapiens_hsa053230.45812181
137Linoleic acid metabolism_Homo sapiens_hsa005910.45360215
138GABAergic synapse_Homo sapiens_hsa047270.43786799
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40278692
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40009010
141Parkinsons disease_Homo sapiens_hsa050120.39908998
142Chemical carcinogenesis_Homo sapiens_hsa052040.38797044
143Metabolic pathways_Homo sapiens_hsa011000.36858552
144Axon guidance_Homo sapiens_hsa043600.36231027
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.35199915
146Choline metabolism in cancer_Homo sapiens_hsa052310.35005515
147Salivary secretion_Homo sapiens_hsa049700.34817487
148ABC transporters_Homo sapiens_hsa020100.34730731
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.33518849
150Endocytosis_Homo sapiens_hsa041440.33402422
151Alzheimers disease_Homo sapiens_hsa050100.32743611
152Inositol phosphate metabolism_Homo sapiens_hsa005620.31978285
153Retinol metabolism_Homo sapiens_hsa008300.31552158
154Cocaine addiction_Homo sapiens_hsa050300.31326584
155Biosynthesis of amino acids_Homo sapiens_hsa012300.29775304
156Renal cell carcinoma_Homo sapiens_hsa052110.29144526
157Insulin secretion_Homo sapiens_hsa049110.29048694
158Vitamin B6 metabolism_Homo sapiens_hsa007500.27254835
159Fructose and mannose metabolism_Homo sapiens_hsa000510.26305925
160Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25944032
161Phagosome_Homo sapiens_hsa041450.24109177
162Protein export_Homo sapiens_hsa030600.24004384
163Cardiac muscle contraction_Homo sapiens_hsa042600.23003569

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