NDRG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.40580838
2synaptic vesicle exocytosis (GO:0016079)6.05401455
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.90271166
4glutamate secretion (GO:0014047)5.75758134
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.65661396
6vocalization behavior (GO:0071625)5.56639800
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.48198644
8regulation of synaptic vesicle exocytosis (GO:2000300)5.46522433
9synaptic vesicle maturation (GO:0016188)5.28921707
10protein localization to synapse (GO:0035418)5.06638343
11locomotory exploration behavior (GO:0035641)5.00402440
12regulation of glutamate receptor signaling pathway (GO:1900449)4.98567060
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.96913427
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.96156959
15neurotransmitter-gated ion channel clustering (GO:0072578)4.95615261
16neuronal action potential propagation (GO:0019227)4.92158958
17regulation of synaptic vesicle transport (GO:1902803)4.80890350
18neuron cell-cell adhesion (GO:0007158)4.78168006
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.70312846
20neurotransmitter secretion (GO:0007269)4.70125726
21synaptic transmission, glutamatergic (GO:0035249)4.54106078
22neuron-neuron synaptic transmission (GO:0007270)4.45389131
23glutamate receptor signaling pathway (GO:0007215)4.35294851
24presynaptic membrane assembly (GO:0097105)4.33942956
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.28169901
26positive regulation of synapse maturation (GO:0090129)4.25497016
27cerebellar granule cell differentiation (GO:0021707)4.18918610
28potassium ion homeostasis (GO:0055075)4.14586478
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.14092220
30neuronal ion channel clustering (GO:0045161)4.13026049
31postsynaptic membrane organization (GO:0001941)4.10081431
32presynaptic membrane organization (GO:0097090)4.07304496
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07197094
34long-term synaptic potentiation (GO:0060291)4.06400170
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.05830870
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.99098929
37exploration behavior (GO:0035640)3.95251663
38gamma-aminobutyric acid transport (GO:0015812)3.92583855
39positive regulation of membrane potential (GO:0045838)3.92564653
40L-amino acid import (GO:0043092)3.92155731
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.87244818
42regulation of neuronal synaptic plasticity (GO:0048168)3.86332768
43amino acid import (GO:0043090)3.83420233
44cerebellar Purkinje cell differentiation (GO:0021702)3.82572052
45neurotransmitter transport (GO:0006836)3.82039225
46regulation of neurotransmitter secretion (GO:0046928)3.82014239
47regulation of postsynaptic membrane potential (GO:0060078)3.80622771
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.80577633
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.71962897
50cellular potassium ion homeostasis (GO:0030007)3.70115557
51cellular sodium ion homeostasis (GO:0006883)3.68407943
52long-term memory (GO:0007616)3.68344753
53regulation of dendritic spine morphogenesis (GO:0061001)3.65733972
54potassium ion import (GO:0010107)3.65505980
55dendritic spine morphogenesis (GO:0060997)3.64583544
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.63223163
57synaptic vesicle endocytosis (GO:0048488)3.62212336
58regulation of ARF protein signal transduction (GO:0032012)3.61804535
59regulation of synaptic plasticity (GO:0048167)3.59835304
60response to histamine (GO:0034776)3.58590873
61cell communication by electrical coupling (GO:0010644)3.57589381
62positive regulation of dendritic spine development (GO:0060999)3.55348246
63positive regulation of neurotransmitter transport (GO:0051590)3.52981423
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.52793385
65positive regulation of neurotransmitter secretion (GO:0001956)3.50778968
66regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.48372159
67regulation of synapse structural plasticity (GO:0051823)3.48367084
68detection of calcium ion (GO:0005513)3.47931362
69regulation of neurotransmitter transport (GO:0051588)3.47421034
70proline transport (GO:0015824)3.45050838
71regulation of neurotransmitter levels (GO:0001505)3.43332344
72regulation of synapse maturation (GO:0090128)3.42661335
73activation of protein kinase A activity (GO:0034199)3.39702319
74establishment of mitochondrion localization (GO:0051654)3.39511868
75regulation of voltage-gated calcium channel activity (GO:1901385)3.35162119
76neuromuscular process controlling balance (GO:0050885)3.35111764
77axonal fasciculation (GO:0007413)3.34633646
78mechanosensory behavior (GO:0007638)3.33853440
79acidic amino acid transport (GO:0015800)3.33008906
80dendritic spine organization (GO:0097061)3.27655291
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.26188086
82startle response (GO:0001964)3.26090447
83membrane depolarization (GO:0051899)3.24856624
84positive regulation of synaptic transmission (GO:0050806)3.24766449
85neurotransmitter uptake (GO:0001504)3.24528028
86vesicle docking involved in exocytosis (GO:0006904)3.24258325
87neuromuscular process controlling posture (GO:0050884)3.24207315
88negative regulation of dendrite morphogenesis (GO:0050774)3.23205783
89energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.22126237
90ATP hydrolysis coupled proton transport (GO:0015991)3.22126237
91transferrin transport (GO:0033572)3.21030560
92regulation of vesicle fusion (GO:0031338)3.20161119
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19906592
94axon ensheathment in central nervous system (GO:0032291)3.19103167
95central nervous system myelination (GO:0022010)3.19103167
96membrane hyperpolarization (GO:0060081)3.18536807
97regulation of dendritic spine development (GO:0060998)3.17895866
98synaptic transmission (GO:0007268)3.15404227
99auditory behavior (GO:0031223)3.14929230
100membrane depolarization during action potential (GO:0086010)3.14854682
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11703212
102behavioral response to cocaine (GO:0048148)3.11413679
103neuron recognition (GO:0008038)3.10202116
104regulation of synaptic transmission (GO:0050804)3.09211474
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07928101
106long term synaptic depression (GO:0060292)3.05728073
107layer formation in cerebral cortex (GO:0021819)3.05711194
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05449995
109vesicle docking (GO:0048278)3.05314047
110cerebellar Purkinje cell layer development (GO:0021680)3.00782722
111learning (GO:0007612)3.00554127
112ferric iron transport (GO:0015682)2.98779691
113trivalent inorganic cation transport (GO:0072512)2.98779691
114cell differentiation in hindbrain (GO:0021533)2.97624784
115sodium ion export (GO:0071436)2.97355021
116behavioral defense response (GO:0002209)2.97306738
117behavioral fear response (GO:0001662)2.97306738
118establishment of synaptic vesicle localization (GO:0097480)2.97280930
119synaptic vesicle transport (GO:0048489)2.97280930
120calcium ion-dependent exocytosis (GO:0017156)2.96314900
121synapse assembly (GO:0007416)2.95317734
122transmission of nerve impulse (GO:0019226)2.94929496
123response to auditory stimulus (GO:0010996)2.94785078
124neuromuscular synaptic transmission (GO:0007274)2.94759924
125positive regulation of synapse assembly (GO:0051965)2.94588982
126positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93307825
127dicarboxylic acid transport (GO:0006835)2.93008809
128innervation (GO:0060384)2.91331982
129cell communication involved in cardiac conduction (GO:0086065)2.89859030
130fear response (GO:0042596)2.89668869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.69122614
2GBX2_23144817_ChIP-Seq_PC3_Human4.35905306
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11712096
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00809440
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84580956
6REST_21632747_ChIP-Seq_MESCs_Mouse2.83486340
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55433260
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52842017
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52842017
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.50662845
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43844414
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42711173
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41682252
14DROSHA_22980978_ChIP-Seq_HELA_Human2.39584020
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.39398910
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37762154
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35949930
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.32135287
19TAF15_26573619_Chip-Seq_HEK293_Human2.21008465
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.21005579
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18753285
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17657480
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16044565
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12901532
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07759166
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.06239724
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.03735573
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95590801
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90524347
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89842746
31SMAD4_21799915_ChIP-Seq_A2780_Human1.89293165
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87988631
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86579343
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86032077
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79578544
36AR_21572438_ChIP-Seq_LNCaP_Human1.77628628
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76554654
38P300_19829295_ChIP-Seq_ESCs_Human1.62828095
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58263316
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53097943
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50071869
42* TET1_21490601_ChIP-Seq_MESCs_Mouse1.48985566
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.47979536
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44871547
45AR_25329375_ChIP-Seq_VCAP_Human1.42279578
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40849691
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39822305
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.38562779
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37697320
50* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36512282
51STAT3_23295773_ChIP-Seq_U87_Human1.34888222
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.34265508
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.33277875
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32548026
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32385359
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.29703941
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.28624566
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28074580
59VDR_22108803_ChIP-Seq_LS180_Human1.27878239
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26387829
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25883428
62* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25624361
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25012347
64TCF4_23295773_ChIP-Seq_U87_Human1.24353634
65ZNF274_21170338_ChIP-Seq_K562_Hela1.23741641
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22969153
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22963564
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21925352
69FUS_26573619_Chip-Seq_HEK293_Human1.21867084
70RNF2_27304074_Chip-Seq_NSC_Mouse1.21801007
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21038930
72* AR_19668381_ChIP-Seq_PC3_Human1.20651889
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20650091
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16524513
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16315289
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14934292
77KDM2B_26808549_Chip-Seq_K562_Human1.12753922
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12309326
79* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12199952
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.12184222
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11213453
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09395674
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09096434
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08079483
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.06752164
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06730582
87ER_23166858_ChIP-Seq_MCF-7_Human1.06622648
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.04817333
89RUNX2_22187159_ChIP-Seq_PCA_Human1.04290451
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04078829
91CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02022652
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00427320
93IGF1R_20145208_ChIP-Seq_DFB_Human0.99943499
94* NANOG_18555785_Chip-Seq_ESCs_Mouse0.99522923
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98822365
96AHR_22903824_ChIP-Seq_MCF-7_Human0.98713596
97* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97785707
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97663775
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97074099
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96323359
101CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96087384
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95700357
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95482895
104* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94866131
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93913721
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93913721
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93424959
108ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92846509
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91672879
110JUN_21703547_ChIP-Seq_K562_Human0.91393628
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91090040
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90547572
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.89466818
114* SOX9_26525672_Chip-Seq_HEART_Mouse0.88594604
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.87417136
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.86167299
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86017774
118RING1B_27294783_Chip-Seq_NPCs_Mouse0.85692182
119RXR_22108803_ChIP-Seq_LS180_Human0.85542376
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85393731
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84359001
122CTCF_27219007_Chip-Seq_Bcells_Human0.83542602
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82612299
124POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.78359283
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77917418
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77707107
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77575973
128NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73581889
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72475982
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72106833
131MYC_19915707_ChIP-ChIP_AK7_Human0.69838750
132* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.68796709
133DPY_21335234_ChIP-Seq_ESCs_Mouse0.68788709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.95669028
2MP0003880_abnormal_central_pattern5.00439846
3MP0003635_abnormal_synaptic_transmissio4.15222674
4MP0009046_muscle_twitch3.67238653
5MP0004270_analgesia3.57945459
6MP0009745_abnormal_behavioral_response3.51184445
7MP0002064_seizures3.40722531
8MP0002063_abnormal_learning/memory/cond3.32663915
9MP0001968_abnormal_touch/_nociception3.24955611
10MP0002572_abnormal_emotion/affect_behav2.94978449
11MP0002272_abnormal_nervous_system2.79716362
12MP0002736_abnormal_nociception_after2.78857962
13MP0002734_abnormal_mechanical_nocicepti2.74292886
14MP0005423_abnormal_somatic_nervous2.53580115
15MP0001486_abnormal_startle_reflex2.52745628
16MP0001501_abnormal_sleep_pattern2.37387231
17MP0002735_abnormal_chemical_nociception2.27672822
18MP0002067_abnormal_sensory_capabilities2.25410170
19MP0009780_abnormal_chondrocyte_physiolo2.16684066
20MP0001440_abnormal_grooming_behavior2.14900719
21MP0008569_lethality_at_weaning2.09941126
22MP0001984_abnormal_olfaction2.03248631
23MP0003787_abnormal_imprinting2.01137509
24MP0002822_catalepsy1.98145466
25MP0005646_abnormal_pituitary_gland1.97651877
26MP0003879_abnormal_hair_cell1.96099885
27MP0001970_abnormal_pain_threshold1.88350134
28MP0005551_abnormal_eye_electrophysiolog1.83747152
29MP0002733_abnormal_thermal_nociception1.81442021
30MP0002184_abnormal_innervation1.76913450
31MP0002557_abnormal_social/conspecific_i1.74244313
32MP0004924_abnormal_behavior1.70452279
33MP0005386_behavior/neurological_phenoty1.70452279
34MP0003123_paternal_imprinting1.64583933
35MP0004811_abnormal_neuron_physiology1.63379600
36MP0000778_abnormal_nervous_system1.53045620
37MP0004142_abnormal_muscle_tone1.48307171
38MP0002909_abnormal_adrenal_gland1.43148879
39MP0002066_abnormal_motor_capabilities/c1.42592378
40MP0002882_abnormal_neuron_morphology1.42448939
41MP0001502_abnormal_circadian_rhythm1.40339882
42MP0006276_abnormal_autonomic_nervous1.38982375
43MP0003122_maternal_imprinting1.38566702
44MP0003329_amyloid_beta_deposits1.38155735
45MP0000955_abnormal_spinal_cord1.37250136
46MP0003633_abnormal_nervous_system1.31300176
47MP0001188_hyperpigmentation1.25477529
48MP0004885_abnormal_endolymph1.25428929
49MP0005645_abnormal_hypothalamus_physiol1.20311084
50MP0001529_abnormal_vocalization1.19670487
51MP0001905_abnormal_dopamine_level1.18004760
52MP0004147_increased_porphyrin_level1.17836030
53MP0002876_abnormal_thyroid_physiology1.16908738
54MP0002229_neurodegeneration1.15651200
55MP0004145_abnormal_muscle_electrophysio1.14586148
56MP0004858_abnormal_nervous_system1.12048394
57MP0010386_abnormal_urinary_bladder1.11880345
58MP0003631_nervous_system_phenotype1.09649272
59MP0000013_abnormal_adipose_tissue1.07948359
60MP0002837_dystrophic_cardiac_calcinosis1.04460918
61MP0008872_abnormal_physiological_respon1.03899627
62MP0003183_abnormal_peptide_metabolism1.03789299
63MP0004043_abnormal_pH_regulation1.03414191
64MP0002152_abnormal_brain_morphology1.01083402
65MP0003121_genomic_imprinting1.00076286
66MP0004742_abnormal_vestibular_system0.98926005
67MP0000751_myopathy0.96496653
68MP0001963_abnormal_hearing_physiology0.96256019
69MP0002069_abnormal_eating/drinking_beha0.91846043
70MP0005253_abnormal_eye_physiology0.89534230
71MP0004233_abnormal_muscle_weight0.88937006
72MP0006072_abnormal_retinal_apoptosis0.86023678
73MP0004215_abnormal_myocardial_fiber0.85299439
74MP0005394_taste/olfaction_phenotype0.84898918
75MP0005499_abnormal_olfactory_system0.84898918
76MP0008874_decreased_physiological_sensi0.83956672
77MP0002653_abnormal_ependyma_morphology0.83860957
78MP0002090_abnormal_vision0.83751158
79MP0005623_abnormal_meninges_morphology0.83695780
80MP0002752_abnormal_somatic_nervous0.82938475
81MP0000604_amyloidosis0.81456894
82MP0004085_abnormal_heartbeat0.78500504
83MP0008877_abnormal_DNA_methylation0.78447438
84MP0005535_abnormal_body_temperature0.76999860
85MP0001346_abnormal_lacrimal_gland0.76973814
86MP0000631_abnormal_neuroendocrine_gland0.75579155
87MP0004484_altered_response_of0.74832424
88MP0003632_abnormal_nervous_system0.73928508
89MP0002638_abnormal_pupillary_reflex0.73659237
90MP0005171_absent_coat_pigmentation0.73341386
91MP0003634_abnormal_glial_cell0.71147701
92MP0001664_abnormal_digestion0.68298615
93MP0001177_atelectasis0.68260410
94MP0001986_abnormal_taste_sensitivity0.66082985
95MP0003861_abnormal_nervous_system0.64796155
96MP0003646_muscle_fatigue0.62869172
97MP0001485_abnormal_pinna_reflex0.62209185
98MP0001299_abnormal_eye_distance/0.59688815
99MP0001348_abnormal_lacrimal_gland0.57028892
100MP0005167_abnormal_blood-brain_barrier0.55391851
101MP0000569_abnormal_digit_pigmentation0.54778115
102MP0001943_abnormal_respiration0.53602599
103* MP0010769_abnormal_survival0.52289465
104MP0003690_abnormal_glial_cell0.52156648
105* MP0010770_preweaning_lethality0.51697167
106* MP0002082_postnatal_lethality0.51697167
107MP0000920_abnormal_myelination0.51086575
108MP0003956_abnormal_body_size0.50983670
109MP0008004_abnormal_stomach_pH0.50585730
110MP0003137_abnormal_impulse_conducting0.50254615
111MP0000026_abnormal_inner_ear0.49970831
112* MP0010768_mortality/aging0.49760286
113MP0002234_abnormal_pharynx_morphology0.49635014
114MP0006035_abnormal_mitochondrial_morpho0.45805004
115MP0000579_abnormal_nail_morphology0.44126471
116MP0000566_synostosis0.43964820

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.46888685
2Epileptic encephalopathy (HP:0200134)6.15459240
3Atonic seizures (HP:0010819)5.76746271
4Focal seizures (HP:0007359)5.74475696
5Myokymia (HP:0002411)5.72945408
6Febrile seizures (HP:0002373)5.41238409
7Visual hallucinations (HP:0002367)5.10853635
8Progressive cerebellar ataxia (HP:0002073)4.79760050
9Absence seizures (HP:0002121)4.57660120
10Hyperventilation (HP:0002883)4.56698581
11Dialeptic seizures (HP:0011146)4.21932786
12Broad-based gait (HP:0002136)4.00364839
13Gaze-evoked nystagmus (HP:0000640)3.95330392
14Generalized tonic-clonic seizures (HP:0002069)3.92933475
15Neurofibrillary tangles (HP:0002185)3.52301251
16Cerebral hypomyelination (HP:0006808)3.42273893
17Action tremor (HP:0002345)3.41352420
18Dysdiadochokinesis (HP:0002075)3.35676452
19Dysmetric saccades (HP:0000641)3.30274546
20Poor eye contact (HP:0000817)3.30066517
21Papilledema (HP:0001085)3.21526764
22Impaired vibration sensation in the lower limbs (HP:0002166)3.19599903
23Tetraplegia (HP:0002445)3.15442227
24Truncal ataxia (HP:0002078)3.12037469
25Abnormal eating behavior (HP:0100738)3.09016056
26Depression (HP:0000716)2.99931913
27Impaired smooth pursuit (HP:0007772)2.98538158
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.96493752
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.96493752
30Abnormal social behavior (HP:0012433)2.95020610
31Impaired social interactions (HP:0000735)2.95020610
32Akinesia (HP:0002304)2.91731089
33Cerebral inclusion bodies (HP:0100314)2.86834949
34Pheochromocytoma (HP:0002666)2.86709000
35Dysmetria (HP:0001310)2.85912866
36Epileptiform EEG discharges (HP:0011182)2.84630408
37Genetic anticipation (HP:0003743)2.80448170
38Anxiety (HP:0000739)2.80076986
39Neuronal loss in central nervous system (HP:0002529)2.79834124
40Diplopia (HP:0000651)2.79128521
41Abnormality of binocular vision (HP:0011514)2.79128521
42Scanning speech (HP:0002168)2.77068575
43Amblyopia (HP:0000646)2.76078972
44Gait imbalance (HP:0002141)2.71635454
45Abnormality of the lower motor neuron (HP:0002366)2.71420816
46Excessive salivation (HP:0003781)2.68246286
47Drooling (HP:0002307)2.68246286
48Abnormality of ocular smooth pursuit (HP:0000617)2.64797099
49Apathy (HP:0000741)2.61798627
50Neuroendocrine neoplasm (HP:0100634)2.60819994
51Urinary bladder sphincter dysfunction (HP:0002839)2.60226922
52Ankle clonus (HP:0011448)2.57859662
53Delusions (HP:0000746)2.57495783
54Peripheral hypomyelination (HP:0007182)2.56981233
55EEG with generalized epileptiform discharges (HP:0011198)2.54835706
56Abnormal hair whorl (HP:0010721)2.54259399
57Protruding tongue (HP:0010808)2.51048188
58Postural instability (HP:0002172)2.49843048
59Clonus (HP:0002169)2.47920602
60Morphological abnormality of the pyramidal tract (HP:0002062)2.47037934
61Central scotoma (HP:0000603)2.46606087
62Congenital primary aphakia (HP:0007707)2.46570523
63CNS hypomyelination (HP:0003429)2.46240800
64Status epilepticus (HP:0002133)2.44619804
65Supranuclear gaze palsy (HP:0000605)2.44386183
66Diminished motivation (HP:0000745)2.43556226
67Impaired vibratory sensation (HP:0002495)2.41074605
68Absent speech (HP:0001344)2.40215068
69Congenital stationary night blindness (HP:0007642)2.37669227
70Medial flaring of the eyebrow (HP:0010747)2.35952938
71Hypsarrhythmia (HP:0002521)2.35701918
72Nephrogenic diabetes insipidus (HP:0009806)2.35033478
73Polyphagia (HP:0002591)2.34835514
74Rigidity (HP:0002063)2.34253935
75Hemiparesis (HP:0001269)2.34071623
76Inability to walk (HP:0002540)2.31164480
77Annular pancreas (HP:0001734)2.30667232
78Bradykinesia (HP:0002067)2.29687167
79Fetal akinesia sequence (HP:0001989)2.28457690
80Hemiplegia (HP:0002301)2.27603064
81Blue irides (HP:0000635)2.25143143
82Progressive inability to walk (HP:0002505)2.23071356
83Insomnia (HP:0100785)2.19280569
84Stereotypic behavior (HP:0000733)2.16370193
85Abnormality of macular pigmentation (HP:0008002)2.14796781
86Specific learning disability (HP:0001328)2.13967175
87Hand muscle atrophy (HP:0009130)2.13835460
88Gait ataxia (HP:0002066)2.13788428
89Choreoathetosis (HP:0001266)2.11101821
90Spastic gait (HP:0002064)2.11027548
91Torticollis (HP:0000473)2.10402888
92Focal dystonia (HP:0004373)2.08771709
93Obstructive sleep apnea (HP:0002870)2.06752579
94Generalized myoclonic seizures (HP:0002123)2.06713141
95Bundle branch block (HP:0011710)2.05738350
96Sleep apnea (HP:0010535)2.04924351
97Spastic tetraparesis (HP:0001285)2.04828140
98Failure to thrive in infancy (HP:0001531)2.04351817
99Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03935812
100Resting tremor (HP:0002322)2.03355582
101Amyotrophic lateral sclerosis (HP:0007354)2.02660379
102Spastic tetraplegia (HP:0002510)2.02059316
103Urinary urgency (HP:0000012)2.01053381
104Mutism (HP:0002300)2.00700180
105Paraplegia (HP:0010550)1.99217001
106Intention tremor (HP:0002080)1.99207188
107Abnormality of saccadic eye movements (HP:0000570)1.98069766
108Incomplete penetrance (HP:0003829)1.96111418
109Limb dystonia (HP:0002451)1.93878492
110Rapidly progressive (HP:0003678)1.93243248
111Muscular hypotonia of the trunk (HP:0008936)1.91038107
112Spinal canal stenosis (HP:0003416)1.90936632
113Diminished movement (HP:0002374)1.90659922
114Limb ataxia (HP:0002070)1.90070565
115Abnormality of the corticospinal tract (HP:0002492)1.86932704
116Spastic paraplegia (HP:0001258)1.85658478
117Poor suck (HP:0002033)1.85502298
118Poor coordination (HP:0002370)1.84293879
119Insidious onset (HP:0003587)1.83074635
120Termporal pattern (HP:0011008)1.83074635
121Increased circulating renin level (HP:0000848)1.81354423
122Hypoventilation (HP:0002791)1.80791220
123Narrow nasal bridge (HP:0000446)1.80708934
124Scotoma (HP:0000575)1.80015331
125Agitation (HP:0000713)1.78971783
126Psychosis (HP:0000709)1.76737958
127Craniofacial dystonia (HP:0012179)1.76703600
128Oligomenorrhea (HP:0000876)1.74774668
129Abnormality of salivation (HP:0100755)1.74452548
130Vaginal atresia (HP:0000148)1.74316236
131Postural tremor (HP:0002174)1.74118457
132Genital tract atresia (HP:0001827)1.73747344
133Sensory axonal neuropathy (HP:0003390)1.71689918
134Lower limb muscle weakness (HP:0007340)1.71568283
135Abnormality of glycolysis (HP:0004366)1.71032767
136Hypoplasia of the corpus callosum (HP:0002079)1.70936420
137Distal upper limb amyotrophy (HP:0007149)1.69885070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.70571194
2NTRK33.98358341
3MAP3K43.52800923
4MAP2K73.38777180
5EPHA43.36715234
6CDK193.11248408
7MAP3K123.03202741
8DAPK22.85634902
9MAP3K92.67878393
10MINK12.21265407
11MAP2K42.19767014
12DAPK12.16802763
13PRPF4B2.13044543
14PLK22.01742261
15MARK11.97280522
16CCNB11.89174324
17PAK61.76954469
18CAMKK21.76706024
19AKT31.69693770
20OXSR11.65589763
21CAMKK11.64476198
22TESK11.54793826
23RIPK41.53811668
24NTRK21.53365762
25LIMK11.47500444
26GRK51.36117025
27CDK51.34710056
28PRKCG1.34687240
29TNIK1.34553971
30MAPK131.26110287
31SGK21.23296444
32KSR11.22347051
33PRKD31.21664469
34SGK4941.21654751
35SGK2231.21654751
36ARAF1.17145810
37KSR21.14183213
38RIPK11.11293274
39STK381.08399415
40SIK31.04841045
41CAMK2A0.99584064
42TSSK60.99006940
43LATS20.97700043
44PTK2B0.95582838
45SGK30.95520384
46BRSK10.94075147
47FES0.91812046
48PDK40.91526400
49PDK30.91526400
50CAMK2B0.91373790
51CDK180.90689767
52NTRK10.90182543
53PNCK0.88208956
54BMPR20.87040976
55CDK150.85090739
56CAMK10.84589727
57PKN10.81777533
58CSNK1G30.81196943
59NME10.78431931
60UHMK10.78357059
61CDK140.77992240
62PINK10.77695941
63SIK20.76903629
64PRKCH0.75586898
65CDK11A0.73602955
66STK110.73211402
67BRAF0.71852656
68MAP3K130.71270139
69ALK0.68763516
70LMTK20.67688306
71PDK10.66297920
72DYRK1A0.66084469
73CSNK1A1L0.66053004
74SGK10.65139813
75MAP3K20.65124133
76TYRO30.62837716
77NEK10.61213536
78PRKCE0.60630511
79TNK20.59088207
80PHKG20.57909695
81PHKG10.57909695
82PDPK10.56874971
83DAPK30.53924991
84WNK10.53188493
85TESK20.52528033
86CAMK40.51868688
87RET0.51702939
88CAMK2D0.51667840
89WNK30.51330132
90CAMK2G0.50114936
91TRIM280.50075799
92PDK20.48048775
93DYRK20.47914466
94CSNK1G10.46583225
95NEK60.46316829
96MAPK70.45613475
97RAF10.43905391
98CDK30.42818201
99FER0.42216023
100RPS6KA30.41517437
101ADRBK10.40945047
102CSNK1G20.40220477
103MAPK120.40191300
104MAP3K10.39287651
105TAOK10.39248843
106ERBB30.38967249
107EPHA30.38451881
108CAMK1G0.38247062
109MAP3K60.37954208
110PAK30.37876336
111CAMK1D0.37360273
112MARK20.37156197
113CDC42BPA0.35825122
114ROCK20.34993778
115BCR0.33209244
116MAP3K110.33154757
117FYN0.31649997
118AURKA0.29994232
119PRKCZ0.29681881
120PRKCB0.29501987
121MAPK100.29405754
122CSNK1E0.29014316
123PRKCA0.28865206
124PRKCI0.25800361

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.12162274
2Nicotine addiction_Homo sapiens_hsa050334.09756928
3Olfactory transduction_Homo sapiens_hsa047402.89562268
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88781145
5GABAergic synapse_Homo sapiens_hsa047272.74261750
6Circadian entrainment_Homo sapiens_hsa047132.73636709
7Collecting duct acid secretion_Homo sapiens_hsa049662.65862859
8Morphine addiction_Homo sapiens_hsa050322.63953531
9Long-term potentiation_Homo sapiens_hsa047202.63198840
10Glutamatergic synapse_Homo sapiens_hsa047242.53332959
11Amphetamine addiction_Homo sapiens_hsa050312.50503651
12Phototransduction_Homo sapiens_hsa047442.31947437
13Dopaminergic synapse_Homo sapiens_hsa047282.12394808
14Salivary secretion_Homo sapiens_hsa049702.10627716
15Insulin secretion_Homo sapiens_hsa049112.10478294
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96206657
17Taste transduction_Homo sapiens_hsa047421.92819542
18Gastric acid secretion_Homo sapiens_hsa049711.76389116
19Cholinergic synapse_Homo sapiens_hsa047251.72543892
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70943436
21Long-term depression_Homo sapiens_hsa047301.70561630
22Vibrio cholerae infection_Homo sapiens_hsa051101.67313463
23Renin secretion_Homo sapiens_hsa049241.64111215
24Serotonergic synapse_Homo sapiens_hsa047261.60996102
25Calcium signaling pathway_Homo sapiens_hsa040201.55746806
26Oxytocin signaling pathway_Homo sapiens_hsa049211.53541585
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42603258
28Cocaine addiction_Homo sapiens_hsa050301.40202915
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35485767
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26694482
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21752090
32cAMP signaling pathway_Homo sapiens_hsa040241.20855003
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20112636
34GnRH signaling pathway_Homo sapiens_hsa049121.19750455
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17446556
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15571783
37Gap junction_Homo sapiens_hsa045401.14522210
38Type II diabetes mellitus_Homo sapiens_hsa049301.11122815
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10408468
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04471464
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03058617
42Vitamin B6 metabolism_Homo sapiens_hsa007501.02470398
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01012399
44Estrogen signaling pathway_Homo sapiens_hsa049150.92342576
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91465157
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90862343
47ErbB signaling pathway_Homo sapiens_hsa040120.88778743
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.84460798
49Cardiac muscle contraction_Homo sapiens_hsa042600.83983556
50Glioma_Homo sapiens_hsa052140.80852250
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80740639
52Pancreatic secretion_Homo sapiens_hsa049720.78682338
53Axon guidance_Homo sapiens_hsa043600.78633758
54Melanogenesis_Homo sapiens_hsa049160.76975486
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75627692
56Circadian rhythm_Homo sapiens_hsa047100.74072819
57Fatty acid biosynthesis_Homo sapiens_hsa000610.71249326
58Oxidative phosphorylation_Homo sapiens_hsa001900.69789208
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69345933
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69138904
61Oocyte meiosis_Homo sapiens_hsa041140.68904928
62Thyroid hormone synthesis_Homo sapiens_hsa049180.67499174
63Rheumatoid arthritis_Homo sapiens_hsa053230.66859476
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64699516
65MAPK signaling pathway_Homo sapiens_hsa040100.63496956
66Arginine and proline metabolism_Homo sapiens_hsa003300.61759170
67Inositol phosphate metabolism_Homo sapiens_hsa005620.59296539
68Glucagon signaling pathway_Homo sapiens_hsa049220.58406892
69Dilated cardiomyopathy_Homo sapiens_hsa054140.57189147
70Type I diabetes mellitus_Homo sapiens_hsa049400.55797986
71Alzheimers disease_Homo sapiens_hsa050100.55207875
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53165415
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.50896733
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50737773
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48940139
76Ras signaling pathway_Homo sapiens_hsa040140.47394619
77Choline metabolism in cancer_Homo sapiens_hsa052310.45959973
78beta-Alanine metabolism_Homo sapiens_hsa004100.40369071
79Phagosome_Homo sapiens_hsa041450.39105720
80Dorso-ventral axis formation_Homo sapiens_hsa043200.38739281
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.38506389
82Arginine biosynthesis_Homo sapiens_hsa002200.37911812
83Alcoholism_Homo sapiens_hsa050340.37871003
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37758106
85AMPK signaling pathway_Homo sapiens_hsa041520.35377606
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34872664
87Prion diseases_Homo sapiens_hsa050200.34777089
88Rap1 signaling pathway_Homo sapiens_hsa040150.34678871
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34040615
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33091194
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32967278
92Endocytosis_Homo sapiens_hsa041440.32965513
93mTOR signaling pathway_Homo sapiens_hsa041500.32674234
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30998968
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30383997
96Butanoate metabolism_Homo sapiens_hsa006500.30262018
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29713198
98VEGF signaling pathway_Homo sapiens_hsa043700.28735054
99Parkinsons disease_Homo sapiens_hsa050120.28497900
100Insulin signaling pathway_Homo sapiens_hsa049100.28066211
101Wnt signaling pathway_Homo sapiens_hsa043100.26540646
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.26494400
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25425030
104Ovarian steroidogenesis_Homo sapiens_hsa049130.25401814
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25124461
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24532382
107Regulation of autophagy_Homo sapiens_hsa041400.23824885
108Bile secretion_Homo sapiens_hsa049760.23672608
109Pyruvate metabolism_Homo sapiens_hsa006200.22983687
110Carbon metabolism_Homo sapiens_hsa012000.22669908
111Tight junction_Homo sapiens_hsa045300.22653490
112Mineral absorption_Homo sapiens_hsa049780.22208572
113Chemokine signaling pathway_Homo sapiens_hsa040620.21907126
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21458560
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.19972529

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »