NDST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)5.09190343
2L-phenylalanine catabolic process (GO:0006559)4.95204836
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.95204836
4L-phenylalanine metabolic process (GO:0006558)4.72450974
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.72450974
6hemidesmosome assembly (GO:0031581)4.65833773
7negative regulation of fibrinolysis (GO:0051918)4.43648015
8sulfur amino acid catabolic process (GO:0000098)4.39983687
9aromatic amino acid family catabolic process (GO:0009074)4.31832482
10cell-substrate junction assembly (GO:0007044)4.30031211
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.18005659
12kynurenine metabolic process (GO:0070189)4.11835716
13endodermal cell differentiation (GO:0035987)4.11508978
14cellular modified amino acid catabolic process (GO:0042219)4.06966488
15protein localization to endosome (GO:0036010)4.05590849
16skin morphogenesis (GO:0043589)4.02177401
17basement membrane organization (GO:0071711)3.98781879
18cell adhesion mediated by integrin (GO:0033627)3.98559701
19protein carboxylation (GO:0018214)3.95106772
20peptidyl-glutamic acid carboxylation (GO:0017187)3.95106772
21regulation of fibrinolysis (GO:0051917)3.93230367
22bile acid biosynthetic process (GO:0006699)3.92476712
23glyoxylate metabolic process (GO:0046487)3.90719767
24COPI coating of Golgi vesicle (GO:0048205)3.83985093
25Golgi transport vesicle coating (GO:0048200)3.83985093
26lysine catabolic process (GO:0006554)3.80270294
27lysine metabolic process (GO:0006553)3.80270294
28urea metabolic process (GO:0019627)3.78676909
29urea cycle (GO:0000050)3.78676909
30coenzyme catabolic process (GO:0009109)3.78576925
31indole-containing compound catabolic process (GO:0042436)3.77026539
32indolalkylamine catabolic process (GO:0046218)3.77026539
33tryptophan catabolic process (GO:0006569)3.77026539
34complement activation, alternative pathway (GO:0006957)3.76228719
35positive regulation of fatty acid beta-oxidation (GO:0032000)3.76225183
36adherens junction assembly (GO:0034333)3.75856991
37regulation of protein activation cascade (GO:2000257)3.75119799
38cysteine metabolic process (GO:0006534)3.70869647
39regulation of cholesterol homeostasis (GO:2000188)3.69810031
40high-density lipoprotein particle remodeling (GO:0034375)3.67866763
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64721674
42cell-substrate adherens junction assembly (GO:0007045)3.62184435
43focal adhesion assembly (GO:0048041)3.62184435
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.62048194
45epoxygenase P450 pathway (GO:0019373)3.58125242
46tryptophan metabolic process (GO:0006568)3.55961445
47cytoskeletal anchoring at plasma membrane (GO:0007016)3.55300699
48regulation of complement activation (GO:0030449)3.53505140
49homocysteine metabolic process (GO:0050667)3.45293467
50regulation of fatty acid beta-oxidation (GO:0031998)3.43692649
51dicarboxylic acid biosynthetic process (GO:0043650)3.43248535
52reverse cholesterol transport (GO:0043691)3.41093579
53vascular endothelial growth factor signaling pathway (GO:0038084)3.37773194
54regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.37747295
55nitrogen cycle metabolic process (GO:0071941)3.36476901
56negative regulation of sterol transport (GO:0032372)3.36445188
57negative regulation of cholesterol transport (GO:0032375)3.36445188
58desmosome organization (GO:0002934)3.35887743
59stress fiber assembly (GO:0043149)3.33865820
60bile acid metabolic process (GO:0008206)3.31689638
61epithelial cell-cell adhesion (GO:0090136)3.30404204
62negative regulation of fatty acid transport (GO:2000192)3.30024414
63hormone catabolic process (GO:0042447)3.29003914
64serine family amino acid catabolic process (GO:0009071)3.28299835
65collagen fibril organization (GO:0030199)3.27232480
66protein retention in ER lumen (GO:0006621)3.26688215
67glutamate metabolic process (GO:0006536)3.24444411
68dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.20586342
69cellular ketone body metabolic process (GO:0046950)3.20509626
70protein heterotrimerization (GO:0070208)3.19756463
71semaphorin-plexin signaling pathway (GO:0071526)3.17759143
72maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16755159
73ethanol oxidation (GO:0006069)3.16101911
74barbed-end actin filament capping (GO:0051016)3.13568182
75phospholipid homeostasis (GO:0055091)3.10686102
76plasma lipoprotein particle clearance (GO:0034381)3.09799524
77amino-acid betaine metabolic process (GO:0006577)3.08818520
78positive regulation of lipid catabolic process (GO:0050996)3.08324647
79chondrocyte proliferation (GO:0035988)3.07989926
80alpha-amino acid catabolic process (GO:1901606)3.07805850
81regulation of triglyceride catabolic process (GO:0010896)3.06521385
82protein-lipid complex remodeling (GO:0034368)3.05581690
83macromolecular complex remodeling (GO:0034367)3.05581690
84plasma lipoprotein particle remodeling (GO:0034369)3.05581690
85acylglycerol homeostasis (GO:0055090)3.05399740
86triglyceride homeostasis (GO:0070328)3.05399740
87positive regulation of blood vessel endothelial cell migration (GO:0043536)3.04016723
88tyrosine metabolic process (GO:0006570)3.03390763
89regulation of early endosome to late endosome transport (GO:2000641)3.03093232
90cellular amino acid catabolic process (GO:0009063)3.00939654
91positive regulation of fatty acid oxidation (GO:0046321)2.99646545
92aromatic amino acid family metabolic process (GO:0009072)2.98148936
93vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.96965448
94midgut development (GO:0007494)2.93914208
95apoptotic cell clearance (GO:0043277)2.93391839
96phospholipid efflux (GO:0033700)2.92467955
97cholesterol efflux (GO:0033344)2.89366941
98cell migration involved in heart development (GO:0060973)2.88174925
99collagen metabolic process (GO:0032963)2.87923821
100acetyl-CoA metabolic process (GO:0006084)2.87485027
101positive regulation of receptor recycling (GO:0001921)2.86633484
102regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.85973038
103retina vasculature morphogenesis in camera-type eye (GO:0061299)2.85540137
104substrate-dependent cell migration (GO:0006929)2.84038703
105endothelial cell morphogenesis (GO:0001886)2.84007784
1062-oxoglutarate metabolic process (GO:0006103)2.82986329
107negative regulation of chondrocyte differentiation (GO:0032331)2.82108698
108drug catabolic process (GO:0042737)2.80971477
109regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.79940470
110cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.79261865
111insulin-like growth factor receptor signaling pathway (GO:0048009)2.78402863
112extracellular matrix disassembly (GO:0022617)2.77081214
113wound healing, spreading of epidermal cells (GO:0035313)2.75571695
114ketone body metabolic process (GO:1902224)2.74864737
115regulation of cholesterol esterification (GO:0010872)2.74158265
116positive regulation of endothelial cell apoptotic process (GO:2000353)2.73919952
117benzene-containing compound metabolic process (GO:0042537)2.73447367
118extracellular matrix assembly (GO:0085029)2.73217693
119fibrinolysis (GO:0042730)2.72191146
120aspartate family amino acid catabolic process (GO:0009068)2.71773150
121multicellular organismal macromolecule metabolic process (GO:0044259)2.71458786
122bile acid and bile salt transport (GO:0015721)2.71025221
123regulation of extracellular matrix disassembly (GO:0010715)2.70508714
124positive regulation of osteoblast proliferation (GO:0033690)2.69162632
125plasma lipoprotein particle assembly (GO:0034377)2.69102892
126collagen catabolic process (GO:0030574)2.69072785
127retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67925880
128lipoprotein metabolic process (GO:0042157)2.67166583
129epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66970039
130extracellular fibril organization (GO:0043206)2.66531282
131surfactant homeostasis (GO:0043129)2.66216804
132linoleic acid metabolic process (GO:0043651)2.65375619
133drug metabolic process (GO:0017144)2.64626351
134protein-lipid complex assembly (GO:0065005)2.64333975
135fatty acid transmembrane transport (GO:1902001)2.62864850
136blood vessel endothelial cell migration (GO:0043534)2.61823793
137regulation of plasminogen activation (GO:0010755)2.60830137
138wound healing, spreading of cells (GO:0044319)2.60734209
139cholesterol homeostasis (GO:0042632)2.59410000
140regulation of cholesterol biosynthetic process (GO:0045540)2.59364491
141bone trabecula formation (GO:0060346)2.59047310
142pyrimidine nucleobase catabolic process (GO:0006208)2.59038094
143cell migration involved in sprouting angiogenesis (GO:0002042)2.58676960
144cortical actin cytoskeleton organization (GO:0030866)2.58385541
145complement activation, classical pathway (GO:0006958)2.58344624
146sterol homeostasis (GO:0055092)2.57524657
147type B pancreatic cell proliferation (GO:0044342)2.56971641
148atrioventricular valve morphogenesis (GO:0003181)2.56583328
149multicellular organismal metabolic process (GO:0044236)2.55974035
150short-chain fatty acid metabolic process (GO:0046459)2.55810060
151cellular glucuronidation (GO:0052695)2.55513825
152regulation of glucose import in response to insulin stimulus (GO:2001273)2.55133930
153negative regulation of lipase activity (GO:0060192)2.54120021
154positive regulation of triglyceride metabolic process (GO:0090208)2.53876413
155biotin metabolic process (GO:0006768)2.53314145
156Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.53165521
157complement activation (GO:0006956)2.52688361
158valine metabolic process (GO:0006573)2.52513289
159indolalkylamine metabolic process (GO:0006586)2.51920501
160neuron projection extension involved in neuron projection guidance (GO:1902284)2.51500947
161axon extension involved in axon guidance (GO:0048846)2.51500947
162carboxylic acid catabolic process (GO:0046395)2.51162536
163organic acid catabolic process (GO:0016054)2.51162536
164negative regulation of protein activation cascade (GO:2000258)2.51084973
165cellular response to vitamin (GO:0071295)2.50136286
166paraxial mesoderm development (GO:0048339)2.47885667
167multicellular organismal catabolic process (GO:0044243)2.47738128
168hypotonic response (GO:0006971)2.46527338
169endocytic recycling (GO:0032456)2.45237516
170positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.44934573
171adhesion of symbiont to host (GO:0044406)2.44348740
172hyaluronan catabolic process (GO:0030214)2.42827143
173fibril organization (GO:0097435)2.41914632
174regulation of establishment of planar polarity (GO:0090175)2.41596601
175venous blood vessel morphogenesis (GO:0048845)2.40936881
176positive regulation of extracellular matrix organization (GO:1903055)2.40936256
177protein targeting to plasma membrane (GO:0072661)2.40412137
178negative regulation of smooth muscle cell migration (GO:0014912)2.40035236
179mesodermal cell differentiation (GO:0048333)2.39307871
180actin filament depolymerization (GO:0030042)2.39180155
181virion attachment to host cell (GO:0019062)2.39034361
182adhesion of symbiont to host cell (GO:0044650)2.39034361
183pinocytosis (GO:0006907)2.38754044
184actin filament bundle organization (GO:0061572)2.38717771
185actin filament bundle assembly (GO:0051017)2.38717771
186glomerular basement membrane development (GO:0032836)2.36702927
187sequestering of extracellular ligand from receptor (GO:0035581)2.36373873
188extracellular matrix organization (GO:0030198)2.35645579
189adherens junction organization (GO:0034332)2.34570265
190extracellular structure organization (GO:0043062)2.34547953
191cell junction assembly (GO:0034329)2.34270494
192cortical cytoskeleton organization (GO:0030865)2.32262126
193vesicle coating (GO:0006901)2.32182741
194endothelial cell chemotaxis (GO:0035767)2.31789049
195membrane protein ectodomain proteolysis (GO:0006509)2.31445382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.22552740
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.67926689
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.05261356
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.94797368
5NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.17005407
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04790551
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.96625020
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.25952628
9CLOCK_20551151_ChIP-Seq_293T_Human2.09717071
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.04494719
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85310460
12RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81882309
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.79658870
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.68313987
15UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.64197843
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62750552
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62726515
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61555920
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.58605933
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55872300
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53707444
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53105656
23KDM2B_26808549_Chip-Seq_K562_Human1.51277159
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49243860
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46884577
26SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46112572
27TP53_22127205_ChIP-Seq_IMR90_Human1.45655352
28* LXR_22292898_ChIP-Seq_THP-1_Human1.45008619
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43898086
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.42335378
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40396089
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39844088
33UBF1/2_26484160_Chip-Seq_HMECs_Human1.39480502
34* ESR1_20079471_ChIP-ChIP_T-47D_Human1.39236502
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38801617
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.37817316
37ZNF263_19887448_ChIP-Seq_K562_Human1.36962218
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.36911441
39* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35916256
40* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35916256
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30162729
42CDX2_20551321_ChIP-Seq_CACO-2_Human1.28218546
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27118569
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25470016
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24965075
46TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22887163
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.22301560
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22224292
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21454150
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21302226
51* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.21243294
52RACK7_27058665_Chip-Seq_MCF-7_Human1.20561487
53* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19299158
54ATF3_27146783_Chip-Seq_COLON_Human1.17953300
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.17483159
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16154508
57* TP53_23651856_ChIP-Seq_MEFs_Mouse1.15407610
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14121431
59* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13901490
60BRD4_25478319_ChIP-Seq_HGPS_Human1.12742246
61* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12494233
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12449246
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12389105
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11671771
65TET1_21490601_ChIP-Seq_MESCs_Mouse1.11384883
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10969554
67KDM2B_26808549_Chip-Seq_DND41_Human1.10214239
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09790071
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09532406
70AHR_22903824_ChIP-Seq_MCF-7_Human1.09317033
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.08762176
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08048346
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07632570
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07632570
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07058086
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06983648
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06242562
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04877731
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02759080
80VDR_21846776_ChIP-Seq_THP-1_Human1.02620491
81CREB1_26743006_Chip-Seq_LNCaP_Human1.02190570
82* TBX20_22328084_ChIP-Seq_HEART_Mouse1.02090312
83* TBX20_22080862_ChIP-Seq_HEART_Mouse1.02090312
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01621509
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01269436
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01027104
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00599021
88* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99307299
89CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99280047
90KDM2B_26808549_Chip-Seq_JURKAT_Human0.98837181
91DROSHA_22980978_ChIP-Seq_HELA_Human0.97968021
92* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97681849
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97591422
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97480535
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96689919
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.96411756
97TCF7_22412390_ChIP-Seq_EML_Mouse0.95789674
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95125522
99* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94726952
100CJUN_26792858_Chip-Seq_BT549_Human0.94397720
101RUNX1_27514584_Chip-Seq_MCF-7_Human0.94277674
102SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94246029
103* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94094798
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94046410
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.93209175
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92953411
107MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92664776
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92514901
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.92403782
110SMC4_20622854_ChIP-Seq_HELA_Human0.92082746
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91289172
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91231578
113ISL1_27105846_Chip-Seq_CPCs_Mouse0.91114367
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.90713492
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90485046
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88171691
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86737457
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86528240
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85653724
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85653724
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85653724
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85579851
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84895751
124GATA1_19941826_ChIP-Seq_K562_Human0.84573513
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84382932
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84382932
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83920261
128* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83899332
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82700412
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82361122
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81058656
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80275650
133SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79880353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.15849825
2MP0005360_urolithiasis5.79665068
3MP0005085_abnormal_gallbladder_physiolo4.44867856
4MP0005365_abnormal_bile_salt4.42764814
5MP0003705_abnormal_hypodermis_morpholog3.90151140
6MP0008875_abnormal_xenobiotic_pharmacok3.58819235
7MP0003252_abnormal_bile_duct3.49086168
8MP0010329_abnormal_lipoprotein_level2.86356803
9MP0005409_darkened_coat_color2.24666616
10MP0005083_abnormal_biliary_tract2.21732035
11MP0008438_abnormal_cutaneous_collagen2.09995565
12MP0009840_abnormal_foam_cell2.09922492
13MP0001666_abnormal_nutrient_absorption1.98878750
14MP0002877_abnormal_melanocyte_morpholog1.93180996
15MP0010368_abnormal_lymphatic_system1.92038189
16MP0005332_abnormal_amino_acid1.90421566
17MP0003806_abnormal_nucleotide_metabolis1.86188160
18MP0002254_reproductive_system_inflammat1.81389481
19MP0003191_abnormal_cellular_cholesterol1.76819050
20MP0000751_myopathy1.73920319
21MP0008961_abnormal_basal_metabolism1.72580888
22MP0003941_abnormal_skin_development1.70584586
23MP0002118_abnormal_lipid_homeostasis1.66898380
24* MP0000609_abnormal_liver_physiology1.65577556
25MP0010234_abnormal_vibrissa_follicle1.64858066
26MP0003195_calcinosis1.64273073
27MP0003011_delayed_dark_adaptation1.61387443
28MP0004858_abnormal_nervous_system1.57824290
29MP0004272_abnormal_basement_membrane1.51780579
30MP0005058_abnormal_lysosome_morphology1.46564432
31MP0005275_abnormal_skin_tensile1.46040146
32MP0003300_gastrointestinal_ulcer1.42052790
33MP0005319_abnormal_enzyme/_coenzyme1.41659124
34MP0003950_abnormal_plasma_membrane1.41282660
35MP0009780_abnormal_chondrocyte_physiolo1.39019271
36MP0005248_abnormal_Harderian_gland1.36808361
37MP0000013_abnormal_adipose_tissue1.33706123
38MP0003868_abnormal_feces_composition1.31146110
39MP0004019_abnormal_vitamin_homeostasis1.29675952
40MP0005451_abnormal_body_composition1.29036920
41MP0004233_abnormal_muscle_weight1.27574715
42MP0006054_spinal_hemorrhage1.27349313
43MP0004264_abnormal_extraembryonic_tissu1.25051285
44MP0003453_abnormal_keratinocyte_physiol1.22742140
45MP0001879_abnormal_lymphatic_vessel1.20614902
46MP0004130_abnormal_muscle_cell1.20566812
47MP0000003_abnormal_adipose_tissue1.20461012
48MP0001348_abnormal_lacrimal_gland1.19054076
49MP0000467_abnormal_esophagus_morphology1.18368941
50MP0002138_abnormal_hepatobiliary_system1.16393168
51MP0001542_abnormal_bone_strength1.15324809
52MP0001299_abnormal_eye_distance/1.13964004
53MP0009384_cardiac_valve_regurgitation1.13455536
54MP0009053_abnormal_anal_canal1.13349890
55MP0001915_intracranial_hemorrhage1.13148168
56MP0006138_congestive_heart_failure1.12623244
57MP0001958_emphysema1.12411719
58MP0002089_abnormal_postnatal_growth/wei1.10626841
59MP0005595_abnormal_vascular_smooth1.07676775
60MP0005584_abnormal_enzyme/coenzyme_acti1.05273028
61MP0002909_abnormal_adrenal_gland1.04448161
62MP0001849_ear_inflammation1.04172826
63MP0003283_abnormal_digestive_organ1.03552900
64MP0008260_abnormal_autophagy1.01895809
65* MP0000762_abnormal_tongue_morphology1.01050197
66MP0003329_amyloid_beta_deposits0.99142911
67MP0003566_abnormal_cell_adhesion0.97201867
68MP0005501_abnormal_skin_physiology0.96902677
69MP0005187_abnormal_penis_morphology0.96027193
70MP0003828_pulmonary_edema0.95077214
71MP0005167_abnormal_blood-brain_barrier0.94772104
72MP0000759_abnormal_skeletal_muscle0.94003140
73MP0003045_fibrosis0.93516548
74MP0010352_gastrointestinal_tract_polyps0.93341617
75MP0005623_abnormal_meninges_morphology0.93311709
76MP0000604_amyloidosis0.93181229
77MP0000428_abnormal_craniofacial_morphol0.92296694
78MP0003279_aneurysm0.91445397
79MP0009643_abnormal_urine_homeostasis0.89669444
80MP0005257_abnormal_intraocular_pressure0.89577307
81MP0000462_abnormal_digestive_system0.89547746
82MP0001614_abnormal_blood_vessel0.89251397
83MP0003385_abnormal_body_wall0.89125432
84MP0000598_abnormal_liver_morphology0.88197320
85MP0002168_other_aberrant_phenotype0.88181651
86MP0000858_altered_metastatic_potential0.85496699
87MP0005023_abnormal_wound_healing0.83779443
88MP0005670_abnormal_white_adipose0.83138373
89MP0000534_abnormal_ureter_morphology0.82198157
90MP0005666_abnormal_adipose_tissue0.81269470
91MP0002998_abnormal_bone_remodeling0.81122375
92MP0003890_abnormal_embryonic-extraembry0.78726305
93MP0003115_abnormal_respiratory_system0.78130481
94MP0002925_abnormal_cardiovascular_devel0.77840265
95MP0002837_dystrophic_cardiac_calcinosis0.77367607
96MP0005076_abnormal_cell_differentiation0.77307695
97MP0000678_abnormal_parathyroid_gland0.75971535
98MP0001756_abnormal_urination0.75767858
99MP0000537_abnormal_urethra_morphology0.75670760
100MP0003448_altered_tumor_morphology0.75535494
101MP0005390_skeleton_phenotype0.74546186
102MP0002249_abnormal_larynx_morphology0.74429107
103MP0004185_abnormal_adipocyte_glucose0.73998708
104MP0002896_abnormal_bone_mineralization0.73932473
105MP0001216_abnormal_epidermal_layer0.73283504
106MP0009250_abnormal_appendicular_skeleto0.72774331
107MP0002295_abnormal_pulmonary_circulatio0.72352638
108MP0000639_abnormal_adrenal_gland0.71293848
109MP0004087_abnormal_muscle_fiber0.71235855
110MP0002796_impaired_skin_barrier0.71202201
111MP0003172_abnormal_lysosome_physiology0.70871838
112MP0003690_abnormal_glial_cell0.69803653
113MP0010771_integument_phenotype0.68931392
114MP0005165_increased_susceptibility_to0.68848869
115MP0002269_muscular_atrophy0.68406636
116MP0005220_abnormal_exocrine_pancreas0.67621619
117MP0010678_abnormal_skin_adnexa0.67378432
118MP0002078_abnormal_glucose_homeostasis0.66272628
119MP0005164_abnormal_response_to0.66233324
120MP0000767_abnormal_smooth_muscle0.66059915
121* MP0005621_abnormal_cell_physiology0.65812283
122MP0000749_muscle_degeneration0.65781986
123MP0003942_abnormal_urinary_system0.65644717
124MP0010630_abnormal_cardiac_muscle0.65392175
125MP0004084_abnormal_cardiac_muscle0.65391997
126MP0000163_abnormal_cartilage_morphology0.64773924
127MP0000747_muscle_weakness0.64767662
128MP0002060_abnormal_skin_morphology0.63428831
129MP0004043_abnormal_pH_regulation0.62736044
130MP0000750_abnormal_muscle_regeneration0.62677471
131MP0002108_abnormal_muscle_morphology0.62301384
132MP0005503_abnormal_tendon_morphology0.62048535
133* MP0003091_abnormal_cell_migration0.61990368
134* MP0005388_respiratory_system_phenotype0.61458117
135* MP0002133_abnormal_respiratory_system0.61458117
136MP0005647_abnormal_sex_gland0.61453430
137MP0002932_abnormal_joint_morphology0.61149384
138MP0000579_abnormal_nail_morphology0.61047352
139MP0004883_abnormal_blood_vessel0.60779467
140* MP0003634_abnormal_glial_cell0.60350227
141MP0002090_abnormal_vision0.59918608
142MP0005375_adipose_tissue_phenotype0.58773458
143MP0002928_abnormal_bile_duct0.58660076
144MP0000733_abnormal_muscle_development0.57922135
145MP0002128_abnormal_blood_circulation0.57061020
146MP0010030_abnormal_orbit_morphology0.55831417
147MP0005334_abnormal_fat_pad0.53819011
148MP0001243_abnormal_dermal_layer0.53552263
149MP0002971_abnormal_brown_adipose0.53276154
150MP0005330_cardiomyopathy0.52754103
151MP0005508_abnormal_skeleton_morphology0.51393893
152MP0003075_altered_response_to0.51275755

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.90968411
2Intrahepatic cholestasis (HP:0001406)4.50237721
3Xanthomatosis (HP:0000991)4.34409618
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.07358099
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.88812777
6Atrophic scars (HP:0001075)3.77029910
7Vascular tortuosity (HP:0004948)3.71867861
8Aortic dissection (HP:0002647)3.67168431
9Complement deficiency (HP:0004431)3.63369314
10Arterial tortuosity (HP:0005116)3.60003764
11Hypobetalipoproteinemia (HP:0003563)3.29703001
12Prolonged partial thromboplastin time (HP:0003645)3.21750389
13Fragile skin (HP:0001030)3.20316302
14Lymphangioma (HP:0100764)3.16938655
15Hyperlipoproteinemia (HP:0010980)3.14614913
16Hypochromic microcytic anemia (HP:0004840)3.10178697
17Hepatoblastoma (HP:0002884)3.07924249
18Spinal rigidity (HP:0003306)3.06356366
19Cervical subluxation (HP:0003308)3.06260852
20Skin nodule (HP:0200036)3.05076784
21Ketosis (HP:0001946)3.02358864
22Hypoalphalipoproteinemia (HP:0003233)3.01994180
23Epidermoid cyst (HP:0200040)3.01540934
24Abnormality of the lower motor neuron (HP:0002366)3.01149486
25Abnormality of the common coagulation pathway (HP:0010990)3.00982635
26Abnormality of the intrinsic pathway (HP:0010989)2.95739554
27Wormian bones (HP:0002645)2.92900423
28Vertebral compression fractures (HP:0002953)2.92139133
29Hypolipoproteinemia (HP:0010981)2.90349725
30Protrusio acetabuli (HP:0003179)2.82355459
31Hyperammonemia (HP:0001987)2.79714151
32Blue sclerae (HP:0000592)2.72858514
33Abnormality of glutamine family amino acid metabolism (HP:0010902)2.68936405
34Abnormality of complement system (HP:0005339)2.67052691
35Soft skin (HP:0000977)2.65512098
36Gout (HP:0001997)2.64656970
37Ulnar bowing (HP:0003031)2.64160036
38Dilatation of the ascending aorta (HP:0005111)2.63936333
39Hyperglycinuria (HP:0003108)2.63523379
40Genu recurvatum (HP:0002816)2.62586454
41Hyperacusis (HP:0010780)2.62031103
42Neonatal short-limb short stature (HP:0008921)2.60416863
43Turricephaly (HP:0000262)2.56174600
44Ketoacidosis (HP:0001993)2.54758548
45Abnormality of glycine metabolism (HP:0010895)2.54303412
46Abnormality of serine family amino acid metabolism (HP:0010894)2.54303412
47Type 1 muscle fiber predominance (HP:0003803)2.53604137
48Broad metatarsal (HP:0001783)2.52421783
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52388931
50Abnormality of the Achilles tendon (HP:0005109)2.51107449
51Joint hemorrhage (HP:0005261)2.49074802
52Mitral valve prolapse (HP:0001634)2.48981011
53Cerebral aneurysm (HP:0004944)2.48393382
54Peritonitis (HP:0002586)2.47954788
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.45589047
56Shallow orbits (HP:0000586)2.42640282
57Follicular hyperkeratosis (HP:0007502)2.39286229
58Mitral stenosis (HP:0001718)2.39047310
59Abnormality of dentin (HP:0010299)2.38996787
60Hypercholesterolemia (HP:0003124)2.36431392
61Mitral regurgitation (HP:0001653)2.34955212
62Hyperglycinemia (HP:0002154)2.33164300
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.33147650
64Osteolytic defects of the hand bones (HP:0009699)2.33147650
65Broad face (HP:0000283)2.32064592
66Myocardial infarction (HP:0001658)2.32043517
67Hepatocellular carcinoma (HP:0001402)2.29182326
68Abnormality of skeletal muscle fiber size (HP:0012084)2.28528499
69Abnormal cartilage morphology (HP:0002763)2.28214713
70Hypoglycemic coma (HP:0001325)2.27058244
71Hyperextensible skin (HP:0000974)2.22999991
72Fat malabsorption (HP:0002630)2.22326175
73Short nail (HP:0001799)2.21804215
74Joint laxity (HP:0001388)2.21667193
75Esophageal varix (HP:0002040)2.21647876
76Thin bony cortex (HP:0002753)2.21214934
77Overgrowth (HP:0001548)2.21210552
78Pseudobulbar signs (HP:0002200)2.20738322
79Natal tooth (HP:0000695)2.20573187
80Increased connective tissue (HP:0009025)2.18033402
81Macroorchidism (HP:0000053)2.15004325
82Distal lower limb amyotrophy (HP:0008944)2.14984268
83Premature rupture of membranes (HP:0001788)2.13629982
84Back pain (HP:0003418)2.12628629
85Aneurysm (HP:0002617)2.12178442
86Obstructive sleep apnea (HP:0002870)2.12145653
87Visceral angiomatosis (HP:0100761)2.10626241
88Spondylolisthesis (HP:0003302)2.10244700
89Spastic diplegia (HP:0001264)2.09676571
90Biconcave vertebral bodies (HP:0004586)2.09189673
91Achilles tendon contracture (HP:0001771)2.07745078
92Bowel diverticulosis (HP:0005222)2.06680281
93Distal lower limb muscle weakness (HP:0009053)2.06535657
94Distal upper limb amyotrophy (HP:0007149)2.04851609
95Upper limb amyotrophy (HP:0009129)2.04851609
96Advanced eruption of teeth (HP:0006288)2.03251226
97Hyperinsulinemic hypoglycemia (HP:0000825)2.01420548
98Abnormality of the acetabulum (HP:0003170)2.00651942
99Malnutrition (HP:0004395)2.00465604
100Delayed CNS myelination (HP:0002188)1.99753720
101Slender build (HP:0001533)1.99053729
102Flat acetabular roof (HP:0003180)1.97210706
103Hemangiomatosis (HP:0007461)1.96347123
104Ankle contracture (HP:0006466)1.95089849
105Elbow flexion contracture (HP:0002987)1.92493510
106Abnormality of purine metabolism (HP:0004352)1.92063333
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88841777
108Difficulty running (HP:0009046)1.87728582
109Hand muscle atrophy (HP:0009130)1.85432682
110Abnormal delivery (HP:0001787)1.85206910
111Wrist flexion contracture (HP:0001239)1.85005482
112Round ear (HP:0100830)1.84000585
113Abnormal ossification of hand bones (HP:0005921)1.83877056
114Amyloidosis (HP:0011034)1.83009734
115Neonatal onset (HP:0003623)1.82973427
116Long toe (HP:0010511)1.82585062
117Bilateral microphthalmos (HP:0007633)1.82456527
118Aortic regurgitation (HP:0001659)1.82358675
119Coxa vara (HP:0002812)1.81759219
120Disproportionate tall stature (HP:0001519)1.81057651
121Asymmetry of the thorax (HP:0001555)1.80372281
122Neoplasm of the heart (HP:0100544)1.78418351
123Arnold-Chiari malformation (HP:0002308)1.78012655
124Cardiovascular calcification (HP:0011915)1.76978348
125Difficulty climbing stairs (HP:0003551)1.76751101
126Lower limb amyotrophy (HP:0007210)1.76363476
127Camptodactyly of toe (HP:0001836)1.75464007
128Hemorrhage of the eye (HP:0011885)1.75297681
129Hypoventilation (HP:0002791)1.73208546
130Abnormality of carpal bone ossification (HP:0006257)1.73039961
131Wide anterior fontanel (HP:0000260)1.72224833
132Ectopia lentis (HP:0001083)1.72000722
133Coronal craniosynostosis (HP:0004440)1.71586453
134Generalized amyotrophy (HP:0003700)1.71266767
135Abnormality of the 4th metacarpal (HP:0010012)1.71109112
136Cerebral inclusion bodies (HP:0100314)1.71054458
137Increased variability in muscle fiber diameter (HP:0003557)1.70763735
138Spinal cord lesions (HP:0100561)1.70200765
139Syringomyelia (HP:0003396)1.70200765
140Insomnia (HP:0100785)1.69903868
141Right ventricular cardiomyopathy (HP:0011663)1.69654115
142Joint stiffness (HP:0001387)1.68500776
143Renal duplication (HP:0000075)1.67908732
144Bowing of the arm (HP:0006488)1.67553412
145Bowed forearm bones (HP:0003956)1.67553412
146Hypoplasia of the iris (HP:0007676)1.66852311
147Ankyloglossia (HP:0010296)1.66394389
148Congenital glaucoma (HP:0001087)1.65397453
149Abnormality of oral frenula (HP:0000190)1.65034101
150Neurofibrillary tangles (HP:0002185)1.64598116
151Mildly elevated creatine phosphokinase (HP:0008180)1.64594012
152Infantile muscular hypotonia (HP:0008947)1.64423346
153Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.64386218
154Polycythemia (HP:0001901)1.64293926
155Abnormality of methionine metabolism (HP:0010901)1.64270161
156Renovascular hypertension (HP:0100817)1.63888275
157Abnormality of fatty-acid metabolism (HP:0004359)1.63613937
158Aortic valve stenosis (HP:0001650)1.62205638
159Subacute progressive viral hepatitis (HP:0006572)1.62019371
160Abnormality of the distal phalanx of the thumb (HP:0009617)1.61092209
161Vascular calcification (HP:0004934)1.61022603
162Nonimmune hydrops fetalis (HP:0001790)1.60911758
163Abnormality of nucleobase metabolism (HP:0010932)1.59950882
164Hamartoma of the eye (HP:0010568)1.59905638
165Bladder diverticulum (HP:0000015)1.58262247
166Aortic aneurysm (HP:0004942)1.56819254
167Hallux valgus (HP:0001822)1.56641304
168Status epilepticus (HP:0002133)1.56209271
169Focal segmental glomerulosclerosis (HP:0000097)1.55855606
170Cholelithiasis (HP:0001081)1.55556622
171Short 4th metacarpal (HP:0010044)1.55437544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.06377360
2TRIB33.79808387
3SIK13.28673932
4CDK122.87325467
5PKN22.63976302
6RIPK12.59969491
7LATS12.23236089
8SMG12.14322215
9FGFR42.12595913
10PDGFRA2.06913547
11MYLK1.98709244
12MAP3K101.91674307
13EPHA21.91160176
14TYRO31.87943412
15PTK61.84605636
16PRPF4B1.75945618
17TESK11.73731035
18FGFR21.71804608
19BCKDK1.71002773
20TTN1.65465888
21TGFBR21.64180678
22NTRK11.60358106
23DDR21.52203986
24NEK91.46852733
25EPHB21.43794948
26MAP3K71.43706917
27IRAK31.43517586
28EPHB11.39830792
29CAMK1D1.37495314
30LATS21.37380373
31ICK1.31522419
32CAMK1G1.31497060
33GRK61.30744333
34RPS6KA21.27134028
35PTK21.26413932
36MAP2K41.22165342
37FGFR31.18392854
38GRK51.16208322
39LIMK11.15476760
40MAP3K31.14297018
41MAP3K61.13993345
42WNK31.12548569
43MTOR1.10964678
44ERBB21.09417759
45RET1.06047123
46EEF2K1.04058328
47BMX1.03087350
48PAK31.02624163
49DAPK20.99405317
50PRKD30.99315136
51MAP3K90.97044141
52MAP2K30.96526799
53CSF1R0.96275741
54PRKCH0.95317205
55PAK60.94555939
56FER0.92179903
57KSR20.90256881
58INSRR0.90077639
59MARK20.88500797
60ARAF0.85695295
61PDGFRB0.85417316
62ROCK20.85325767
63TRPM70.85254367
64PRKG20.84728810
65MAPK70.79901154
66LRRK20.79817590
67WNK10.79766979
68LMTK20.79680941
69CAMK40.76714002
70CAMKK10.75763995
71MAP3K20.75371252
72PAK40.73897179
73MST1R0.72797492
74TAOK10.71000757
75STK380.69222668
76EPHA30.67914565
77FGFR10.66545386
78PAK20.65441971
79MET0.65413662
80FRK0.63175709
81DYRK1B0.62319249
82PHKG20.62124334
83PHKG10.62124334
84ROCK10.62121460
85TIE10.61861821
86MARK10.61651459
87PRKD10.61632329
88DMPK0.61563647
89GRK10.60844157
90ALK0.59420901
91TAOK20.59017686
92ERBB40.58472126
93MATK0.58352529
94MAP3K10.58191161
95RPS6KC10.57341927
96RPS6KL10.57341927
97MAPK120.56919049
98SGK30.56894786
99CDK60.55897240
100MAPKAPK30.55806216
101PRKAA10.55374902
102ILK0.55306082
103GSK3A0.55080913
104KDR0.55040712
105SIK20.54672226
106JAK10.54625828
107KSR10.53693452
108PRKCZ0.53352314
109SCYL20.52288597
110TAOK30.51584028
111STK100.51309157
112ZAP700.49314143
113MAP3K130.49189647
114NTRK20.49122597
115CSK0.49115669
116FLT30.48319705
117MAP3K80.47050982
118MOS0.46983025
119HIPK20.46379175
120JAK20.46363442
121DAPK30.45699160
122PRKAA20.44119225
123AKT30.44093663
124MAPK110.43012438
125STK30.42911136
126PIM20.42507501
127PRKD20.42500567
128PTK2B0.42413888
129ABL20.42329314
130PIK3CG0.41612407
131CDC42BPA0.40782134
132EPHA40.40530583
133PDPK10.39415232
134SRC0.37947305
135CAMK2G0.37750261
136IGF1R0.37215308
137MAP2K10.36934996
138RPS6KA60.33768463
139MAPKAPK20.31033608
140MELK0.30313333

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.03684611
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.47513346
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.91798020
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68441258
5Arginine biosynthesis_Homo sapiens_hsa002202.65260827
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.40920448
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36553463
8Complement and coagulation cascades_Homo sapiens_hsa046102.32247231
9Tryptophan metabolism_Homo sapiens_hsa003802.31294242
10Fatty acid degradation_Homo sapiens_hsa000712.23782688
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06502539
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97844711
13Butanoate metabolism_Homo sapiens_hsa006501.88524270
14PPAR signaling pathway_Homo sapiens_hsa033201.86427752
15Bile secretion_Homo sapiens_hsa049761.81190438
16Fatty acid metabolism_Homo sapiens_hsa012121.80085683
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.77642254
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.76849799
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67528522
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63148376
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59119352
22Chronic myeloid leukemia_Homo sapiens_hsa052201.56999211
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50483455
24Other glycan degradation_Homo sapiens_hsa005111.50319687
25Caffeine metabolism_Homo sapiens_hsa002321.49772590
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49251258
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47640865
28Propanoate metabolism_Homo sapiens_hsa006401.46506477
29Small cell lung cancer_Homo sapiens_hsa052221.44883713
30Chemical carcinogenesis_Homo sapiens_hsa052041.39245501
31Notch signaling pathway_Homo sapiens_hsa043301.38195118
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.33997463
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33978820
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33895339
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30293387
36Peroxisome_Homo sapiens_hsa041461.30082441
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.28619150
38Lysine degradation_Homo sapiens_hsa003101.26737018
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.20691027
40Histidine metabolism_Homo sapiens_hsa003401.18641599
41beta-Alanine metabolism_Homo sapiens_hsa004101.17954202
42Renal cell carcinoma_Homo sapiens_hsa052111.17155632
43Pancreatic cancer_Homo sapiens_hsa052121.16959467
44VEGF signaling pathway_Homo sapiens_hsa043701.16509342
45Thyroid cancer_Homo sapiens_hsa052161.16003560
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15128734
47MicroRNAs in cancer_Homo sapiens_hsa052061.13120231
48Selenocompound metabolism_Homo sapiens_hsa004501.11442887
49Starch and sucrose metabolism_Homo sapiens_hsa005001.10749262
50Staphylococcus aureus infection_Homo sapiens_hsa051501.08987422
51Retinol metabolism_Homo sapiens_hsa008301.07427523
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06303137
53ABC transporters_Homo sapiens_hsa020101.03573560
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.03281152
55Fat digestion and absorption_Homo sapiens_hsa049751.02755638
56Estrogen signaling pathway_Homo sapiens_hsa049150.99518713
57GnRH signaling pathway_Homo sapiens_hsa049120.96678792
58ErbB signaling pathway_Homo sapiens_hsa040120.96308406
59Fatty acid biosynthesis_Homo sapiens_hsa000610.95677852
60Acute myeloid leukemia_Homo sapiens_hsa052210.95246745
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95189749
62Pyruvate metabolism_Homo sapiens_hsa006200.92433865
63Phenylalanine metabolism_Homo sapiens_hsa003600.92061242
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91537519
65Tight junction_Homo sapiens_hsa045300.91231092
66Rap1 signaling pathway_Homo sapiens_hsa040150.90646325
67Prostate cancer_Homo sapiens_hsa052150.88594438
68Vitamin B6 metabolism_Homo sapiens_hsa007500.87483662
69Gap junction_Homo sapiens_hsa045400.86846635
70Carbon metabolism_Homo sapiens_hsa012000.86578724
71Endocytosis_Homo sapiens_hsa041440.86317215
72Melanogenesis_Homo sapiens_hsa049160.85971426
73Tyrosine metabolism_Homo sapiens_hsa003500.85365465
74Sulfur metabolism_Homo sapiens_hsa009200.84523286
75Insulin resistance_Homo sapiens_hsa049310.83686760
76Pathways in cancer_Homo sapiens_hsa052000.83566999
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.82410937
78Biosynthesis of amino acids_Homo sapiens_hsa012300.82147337
79Melanoma_Homo sapiens_hsa052180.79901675
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78967963
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76713293
82Vibrio cholerae infection_Homo sapiens_hsa051100.76142325
83Lysosome_Homo sapiens_hsa041420.75598633
84Platelet activation_Homo sapiens_hsa046110.75094750
85Choline metabolism in cancer_Homo sapiens_hsa052310.72032628
86Pentose phosphate pathway_Homo sapiens_hsa000300.70397004
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70149489
88Shigellosis_Homo sapiens_hsa051310.68588672
89Glycerolipid metabolism_Homo sapiens_hsa005610.67163356
90Prolactin signaling pathway_Homo sapiens_hsa049170.67146142
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.67016867
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.63730566
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.63383116
94Fatty acid elongation_Homo sapiens_hsa000620.62562969
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62068928
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61319342
97Salmonella infection_Homo sapiens_hsa051320.61048253
98ECM-receptor interaction_Homo sapiens_hsa045120.60662682
99Inositol phosphate metabolism_Homo sapiens_hsa005620.60486708
100AMPK signaling pathway_Homo sapiens_hsa041520.60434629
101Thyroid hormone synthesis_Homo sapiens_hsa049180.60108011
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59890542
103mTOR signaling pathway_Homo sapiens_hsa041500.59285849
104Malaria_Homo sapiens_hsa051440.58941821
105Colorectal cancer_Homo sapiens_hsa052100.57517499
106Focal adhesion_Homo sapiens_hsa045100.57362316
107Long-term potentiation_Homo sapiens_hsa047200.55950259
108Hepatitis C_Homo sapiens_hsa051600.54944633
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54594594
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.53306940
111TGF-beta signaling pathway_Homo sapiens_hsa043500.52775430
112Steroid biosynthesis_Homo sapiens_hsa001000.52477714
113Toxoplasmosis_Homo sapiens_hsa051450.52190356
114Sphingolipid metabolism_Homo sapiens_hsa006000.51827444
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51779436
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50902248
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.50125624
118Pertussis_Homo sapiens_hsa051330.49181053
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.49173141
120Prion diseases_Homo sapiens_hsa050200.48767366
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48184365
122Arginine and proline metabolism_Homo sapiens_hsa003300.48044414
123Proteoglycans in cancer_Homo sapiens_hsa052050.47702202
124Protein digestion and absorption_Homo sapiens_hsa049740.46434976
125Amoebiasis_Homo sapiens_hsa051460.44714283
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.44709390
127Dorso-ventral axis formation_Homo sapiens_hsa043200.43716480
128Ovarian steroidogenesis_Homo sapiens_hsa049130.43432666
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43104656
130Vitamin digestion and absorption_Homo sapiens_hsa049770.42913501
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42450148
132Insulin signaling pathway_Homo sapiens_hsa049100.42373650
133Adherens junction_Homo sapiens_hsa045200.42295603
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41973439
135Glucagon signaling pathway_Homo sapiens_hsa049220.41759113
136Galactose metabolism_Homo sapiens_hsa000520.40478977
137Bladder cancer_Homo sapiens_hsa052190.39937299
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39931845
139* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37131351
140Fructose and mannose metabolism_Homo sapiens_hsa000510.36753943
141Dilated cardiomyopathy_Homo sapiens_hsa054140.36504823
142Type II diabetes mellitus_Homo sapiens_hsa049300.36098560
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34926248
144Endometrial cancer_Homo sapiens_hsa052130.33884103
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33756369
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33027980
147Non-small cell lung cancer_Homo sapiens_hsa052230.32928081
148Glioma_Homo sapiens_hsa052140.32495368
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31119267
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30613741
151Basal cell carcinoma_Homo sapiens_hsa052170.30344500
152Axon guidance_Homo sapiens_hsa043600.30081366
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30012538
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.27010596
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25208355
156Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23775490
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23074162
158Hippo signaling pathway_Homo sapiens_hsa043900.22646667

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