NDST2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88318309
2negative regulation of cell killing (GO:0031342)4.88318309
3negative regulation of interleukin-12 production (GO:0032695)4.65171560
4response to peptidoglycan (GO:0032494)4.59758564
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.50563109
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.50563109
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48061263
8definitive hemopoiesis (GO:0060216)4.38611556
9positive regulation of B cell differentiation (GO:0045579)4.33412922
10antigen processing and presentation of endogenous antigen (GO:0019883)3.97894477
11positive regulation of gamma-delta T cell activation (GO:0046645)3.78659672
12regulation of interferon-beta biosynthetic process (GO:0045357)3.75685071
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.69903828
14detection of other organism (GO:0098543)3.67644806
15germinal center formation (GO:0002467)3.67477482
16neutrophil activation involved in immune response (GO:0002283)3.64597454
17negative regulation of erythrocyte differentiation (GO:0045647)3.54974289
18lipopolysaccharide-mediated signaling pathway (GO:0031663)3.53824124
19detection of bacterium (GO:0016045)3.50570286
20positive regulation of mast cell activation involved in immune response (GO:0033008)3.50340726
21positive regulation of mast cell degranulation (GO:0043306)3.50340726
22regulation of T-helper 1 cell differentiation (GO:0045625)3.49053003
23megakaryocyte development (GO:0035855)3.48192366
24leukocyte aggregation (GO:0070486)3.47234164
25cellular extravasation (GO:0045123)3.41400703
26production of molecular mediator involved in inflammatory response (GO:0002532)3.37484737
27regulation of T-helper 2 cell differentiation (GO:0045628)3.36512524
28negative regulation of T cell mediated immunity (GO:0002710)3.36296866
29immunoglobulin mediated immune response (GO:0016064)3.33304471
30regulation of B cell differentiation (GO:0045577)3.32903146
31regulation of T cell tolerance induction (GO:0002664)3.32734872
32tolerance induction (GO:0002507)3.32485820
33regulation of vitamin D biosynthetic process (GO:0060556)3.32012993
34antigen processing and presentation via MHC class Ib (GO:0002475)3.29064362
35regulation of erythrocyte differentiation (GO:0045646)3.26913220
36regulation of hypersensitivity (GO:0002883)3.25586477
37negative regulation of phagocytosis (GO:0050765)3.24664027
38negative regulation of cytokine production involved in immune response (GO:0002719)3.24202328
39regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21289411
40negative regulation of granulocyte differentiation (GO:0030853)3.16831587
41positive regulation by symbiont of host defense response (GO:0052509)3.14653789
42modulation by symbiont of host defense response (GO:0052031)3.14653789
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14653789
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14653789
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.14653789
46modulation by symbiont of host immune response (GO:0052553)3.14653789
47positive regulation of mast cell activation (GO:0033005)3.14334349
48regulation of B cell receptor signaling pathway (GO:0050855)3.12026038
49positive regulation of interferon-alpha production (GO:0032727)3.11639027
50detection of external biotic stimulus (GO:0098581)3.09613473
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.08869044
52detection of molecule of bacterial origin (GO:0032490)3.08650020
53interferon-gamma-mediated signaling pathway (GO:0060333)3.07569826
54T cell migration (GO:0072678)3.06717193
55regulation of apoptotic cell clearance (GO:2000425)3.04438942
56regulation of tolerance induction (GO:0002643)3.03935983
57regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03264848
58regulation of gamma-delta T cell differentiation (GO:0045586)3.03109058
59myeloid dendritic cell differentiation (GO:0043011)3.02129992
60positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.98804182
61valine metabolic process (GO:0006573)2.98501853
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97722642
63positive regulation of type 2 immune response (GO:0002830)2.94176765
64regulation of interferon-alpha production (GO:0032647)2.92257277
65response to host immune response (GO:0052572)2.90824672
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90824672
67myeloid cell activation involved in immune response (GO:0002275)2.90295262
68negative regulation of leukocyte mediated immunity (GO:0002704)2.90004647
69positive regulation of erythrocyte differentiation (GO:0045648)2.87909692
70positive regulation of histone deacetylation (GO:0031065)2.87831884
71positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87334760
72positive regulation of natural killer cell differentiation (GO:0032825)2.85684524
73regulation of leukocyte degranulation (GO:0043300)2.84523669
74peptidyl-glutamic acid carboxylation (GO:0017187)2.83512118
75protein carboxylation (GO:0018214)2.83512118
76negative thymic T cell selection (GO:0045060)2.82846345
77regulation of type 2 immune response (GO:0002828)2.82243177
78granulocyte activation (GO:0036230)2.81684574
79detection of biotic stimulus (GO:0009595)2.81463456
80positive regulation of leukocyte degranulation (GO:0043302)2.81355285
81negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.81016573
82negative regulation of interleukin-6 production (GO:0032715)2.80908331
83regulation of interleukin-2 biosynthetic process (GO:0045076)2.78553229
84response to interleukin-15 (GO:0070672)2.76111767
85complement activation, alternative pathway (GO:0006957)2.75854291
86mannose metabolic process (GO:0006013)2.75790891
87negative regulation of type 2 immune response (GO:0002829)2.74847708
88macrophage activation (GO:0042116)2.74312653
89regulation of gamma-delta T cell activation (GO:0046643)2.74159553
90myeloid dendritic cell activation (GO:0001773)2.73419761
91regulation of antigen processing and presentation (GO:0002577)2.72721794
92response to host defenses (GO:0052200)2.72354941
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72354941
94response to host (GO:0075136)2.72354941
95urea metabolic process (GO:0019627)2.72098078
96urea cycle (GO:0000050)2.72098078
97positive regulation of chemokine biosynthetic process (GO:0045080)2.72037386
98response to interferon-alpha (GO:0035455)2.71903254
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.71631390
100negative regulation of production of molecular mediator of immune response (GO:0002701)2.71242867
101pinocytosis (GO:0006907)2.71113271
102positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.70801418
103regulation of interleukin-12 production (GO:0032655)2.70067708
104T-helper 1 type immune response (GO:0042088)2.69191599
105negative T cell selection (GO:0043383)2.68049230
106positive regulation of tolerance induction (GO:0002645)2.67867073
107response to muramyl dipeptide (GO:0032495)2.67463974
108neutrophil activation (GO:0042119)2.67199996
109response to type I interferon (GO:0034340)2.67135841
110regulation of chemokine biosynthetic process (GO:0045073)2.66988905
111B cell receptor signaling pathway (GO:0050853)2.66137769
112thrombin receptor signaling pathway (GO:0070493)2.66033475
113regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.65905064
114positive regulation of antigen processing and presentation (GO:0002579)2.65479481
115T cell selection (GO:0045058)2.64783767
116regulation of chronic inflammatory response (GO:0002676)2.64371934
117regulation of mast cell degranulation (GO:0043304)2.64060401
118positive regulation of protein deacetylation (GO:0090312)2.62298905
119type I interferon signaling pathway (GO:0060337)2.60813565
120cellular response to type I interferon (GO:0071357)2.60813565
121embryonic hemopoiesis (GO:0035162)2.60298976
122epithelial cell differentiation involved in prostate gland development (GO:0060742)2.59903734
123JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56824925
124angiotensin maturation (GO:0002003)2.56627202
125regulation of necroptotic process (GO:0060544)2.56193442
126erythrocyte maturation (GO:0043249)2.55757117
127positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54540852
128positive regulation of triglyceride biosynthetic process (GO:0010867)2.54245569
129natural killer cell differentiation (GO:0001779)2.52635292
130positive regulation of macrophage differentiation (GO:0045651)2.51117655
131interferon-gamma production (GO:0032609)2.50485813
132B cell mediated immunity (GO:0019724)2.48177374
133germ cell migration (GO:0008354)2.44516604
134NIK/NF-kappaB signaling (GO:0038061)2.43301255
135triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.41533154
136L-alpha-amino acid transmembrane transport (GO:1902475)2.41176933
137regulation of mast cell activation involved in immune response (GO:0033006)2.39927840
138fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.39810944
139regulation of protein activation cascade (GO:2000257)2.37540581
140regulation of type I interferon-mediated signaling pathway (GO:0060338)2.36394722
141regulation of cholesterol storage (GO:0010885)2.36052104
142nitrogen cycle metabolic process (GO:0071941)2.36020805
143T cell homeostasis (GO:0043029)2.35218888
144plasma lipoprotein particle assembly (GO:0034377)2.34748532
145gland morphogenesis (GO:0022612)2.33635071
146macrophage activation involved in immune response (GO:0002281)2.32462357
147protein-lipid complex assembly (GO:0065005)2.30207863
148complement activation, classical pathway (GO:0006958)2.30088746
149regulation of phagocytosis (GO:0050764)2.29832244
150phospholipid efflux (GO:0033700)2.29649894
151response to protozoan (GO:0001562)2.29161797
152regulation of complement activation (GO:0030449)2.28960943
153positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.28857785
154complement activation (GO:0006956)2.28603901
155sulfur amino acid catabolic process (GO:0000098)2.28255562
156positive regulation of developmental pigmentation (GO:0048087)2.26492832
157blood coagulation, intrinsic pathway (GO:0007597)2.26234580
158negative regulation of fibrinolysis (GO:0051918)2.24590963
159mast cell activation (GO:0045576)2.24470344
160alpha-linolenic acid metabolic process (GO:0036109)2.24170871
161protein activation cascade (GO:0072376)2.23936669
162defense response to protozoan (GO:0042832)2.23718776
163indolalkylamine catabolic process (GO:0046218)2.23291246
164tryptophan catabolic process (GO:0006569)2.23291246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.46482289
2E2F7_22180533_ChIP-Seq_HELA_Human4.26789863
3SCL_19346495_ChIP-Seq_HPC-7_Human3.95177372
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.81120628
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.57608894
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.01351017
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.97928111
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97794478
9GATA1_22025678_ChIP-Seq_K562_Human2.78794892
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54582715
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.54411762
12* RXR_22158963_ChIP-Seq_LIVER_Mouse2.53607013
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52495682
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52017517
15MYC_22102868_ChIP-Seq_BL_Human2.50731784
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46409036
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45058302
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31767135
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31700798
20VDR_21846776_ChIP-Seq_THP-1_Human2.29463913
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28304979
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25820347
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20475052
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.19125493
25* TCF7_22412390_ChIP-Seq_EML_Mouse2.18907872
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06790285
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05308514
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99752009
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.96191786
30VDR_24763502_ChIP-Seq_THP-1_Human1.96143277
31* MAF_26560356_Chip-Seq_TH1_Human1.93162121
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90062160
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89847961
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89239772
35* RUNX1_22412390_ChIP-Seq_EML_Mouse1.88607176
36* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.81284153
37* GATA1_19941827_ChIP-Seq_MEL_Mouse1.80427685
38SPI1_23547873_ChIP-Seq_NB4_Human1.74474081
39* MYB_26560356_Chip-Seq_TH1_Human1.70795511
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70631686
41GATA1_22383799_ChIP-Seq_G1ME_Mouse1.69473673
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68299059
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66497175
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65465118
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.64098110
46MYB_26560356_Chip-Seq_TH2_Human1.63760862
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61464399
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57703506
49VDR_24787735_ChIP-Seq_THP-1_Human1.56267388
50* UTX_26944678_Chip-Seq_JUKART_Human1.54657088
51RUNX_20019798_ChIP-Seq_JUKART_Human1.52956059
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52260983
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.51913693
54SPI1_23127762_ChIP-Seq_K562_Human1.50583187
55* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49830173
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49768111
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.48871390
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47911277
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46706833
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46215142
61* KDM2B_26808549_Chip-Seq_JURKAT_Human1.43116708
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42883259
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42732256
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40484761
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37279756
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36893842
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36282555
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34672001
69GATA1_19941826_ChIP-Seq_K562_Human1.34258365
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34119233
71* KDM2B_26808549_Chip-Seq_DND41_Human1.31065123
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30428833
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28694299
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25517217
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25165713
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22720990
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22451784
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22422966
79LXR_22292898_ChIP-Seq_THP-1_Human1.21575527
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20343467
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18820237
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18449047
83KDM2B_26808549_Chip-Seq_K562_Human1.17907177
84PU_27001747_Chip-Seq_BMDM_Mouse1.17109665
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16443089
86RACK7_27058665_Chip-Seq_MCF-7_Human1.16264951
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16091882
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15573572
89NCOR1_26117541_ChIP-Seq_K562_Human1.14985710
90GATA2_19941826_ChIP-Seq_K562_Human1.12775662
91* MAF_26560356_Chip-Seq_TH2_Human1.11431554
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09863062
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09199006
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07800216
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06895159
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05377642
97TP63_17297297_ChIP-ChIP_HaCaT_Human1.02518965
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02437584
99CLOCK_20551151_ChIP-Seq_293T_Human1.01836890
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01797988
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.00716985
102NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99741505
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98572010
104BCOR_27268052_Chip-Seq_Bcells_Human0.98448799
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98216218
106* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97893279
107BCL6_27268052_Chip-Seq_Bcells_Human0.97231865
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97152861
109GATA3_27048872_Chip-Seq_THYMUS_Human0.96221979
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.95694020
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94928190
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.92935933
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92399727
114* SA1_27219007_Chip-Seq_ERYTHROID_Human0.91636173
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91535899
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91216772
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90667058
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90142473
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88177236
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86455707
121TFEB_21752829_ChIP-Seq_HELA_Human0.86081831
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84370355
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84173547
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83514518
125E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82429356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.96876963
2MP0002139_abnormal_hepatobiliary_system2.82859445
3MP0005075_abnormal_melanosome_morpholog2.54564159
4MP0002396_abnormal_hematopoietic_system2.52982869
5MP0005464_abnormal_platelet_physiology2.42465490
6MP0005360_urolithiasis2.31121996
7MP0009840_abnormal_foam_cell2.27979860
8MP0004510_myositis2.24869210
9* MP0003436_decreased_susceptibility_to2.21747815
10MP0003300_gastrointestinal_ulcer2.18213707
11MP0003191_abnormal_cellular_cholesterol2.05157914
12MP0001800_abnormal_humoral_immune2.04983565
13MP0005365_abnormal_bile_salt2.03738831
14* MP0005025_abnormal_response_to2.00071145
15MP0003303_peritoneal_inflammation1.98549501
16MP0003705_abnormal_hypodermis_morpholog1.97592479
17MP0000685_abnormal_immune_system1.95146887
18MP0002419_abnormal_innate_immunity1.94660438
19MP0005058_abnormal_lysosome_morphology1.94366459
20MP0004808_abnormal_hematopoietic_stem1.90001145
21MP0000465_gastrointestinal_hemorrhage1.89859313
22MP0005397_hematopoietic_system_phenotyp1.88269668
23MP0001545_abnormal_hematopoietic_system1.88269668
24MP0002452_abnormal_antigen_presenting1.88228126
25MP0005387_immune_system_phenotype1.87769748
26MP0001790_abnormal_immune_system1.87769748
27MP0003656_abnormal_erythrocyte_physiolo1.83579559
28MP0006054_spinal_hemorrhage1.83102680
29* MP0005000_abnormal_immune_tolerance1.78752981
30MP0009278_abnormal_bone_marrow1.77999456
31MP0005671_abnormal_response_to1.73996360
32MP0002398_abnormal_bone_marrow1.72119751
33MP0005085_abnormal_gallbladder_physiolo1.69869294
34MP0002723_abnormal_immune_serum1.69036043
35* MP0002420_abnormal_adaptive_immunity1.65482865
36* MP0001819_abnormal_immune_cell1.64170487
37MP0003172_abnormal_lysosome_physiology1.60729096
38MP0009785_altered_susceptibility_to1.60070390
39MP0005310_abnormal_salivary_gland1.59035219
40MP0008260_abnormal_autophagy1.56756221
41MP0006082_CNS_inflammation1.56648689
42MP0000689_abnormal_spleen_morphology1.55317110
43MP0002166_altered_tumor_susceptibility1.52788337
44MP0010352_gastrointestinal_tract_polyps1.52145274
45MP0002998_abnormal_bone_remodeling1.52056877
46MP0010368_abnormal_lymphatic_system1.51290696
47MP0003252_abnormal_bile_duct1.50396978
48MP0010329_abnormal_lipoprotein_level1.48628328
49MP0003075_altered_response_to1.48614342
50MP0002722_abnormal_immune_system1.46679937
51MP0002148_abnormal_hypersensitivity_rea1.45747765
52* MP0000716_abnormal_immune_system1.45510512
53MP0000490_abnormal_crypts_of1.44684106
54MP0008961_abnormal_basal_metabolism1.44314171
55MP0001853_heart_inflammation1.41709488
56MP0002405_respiratory_system_inflammati1.41559273
57MP0010155_abnormal_intestine_physiology1.39108727
58* MP0002429_abnormal_blood_cell1.39086473
59MP0000604_amyloidosis1.35407588
60MP0000609_abnormal_liver_physiology1.34236231
61MP0004947_skin_inflammation1.33587450
62MP0008469_abnormal_protein_level1.33049817
63MP0008004_abnormal_stomach_pH1.32816244
64MP0003828_pulmonary_edema1.31728446
65MP0001845_abnormal_inflammatory_respons1.28387609
66MP0008875_abnormal_xenobiotic_pharmacok1.27494015
67MP0009333_abnormal_splenocyte_physiolog1.25370156
68MP0003763_abnormal_thymus_physiology1.24979990
69MP0004264_abnormal_extraembryonic_tissu1.23482655
70MP0005174_abnormal_tail_pigmentation1.22198308
71MP0001873_stomach_inflammation1.21721119
72MP0005083_abnormal_biliary_tract1.21250909
73MP0002877_abnormal_melanocyte_morpholog1.21177699
74MP0003448_altered_tumor_morphology1.20798407
75MP0000343_altered_response_to1.19341474
76MP0001915_intracranial_hemorrhage1.18059842
77MP0003724_increased_susceptibility_to1.15208054
78MP0010307_abnormal_tumor_latency1.14596233
79MP0001851_eye_inflammation1.13732734
80MP0003091_abnormal_cell_migration1.13586745
81MP0003453_abnormal_keratinocyte_physiol1.13106879
82* MP0001533_abnormal_skeleton_physiology1.12412025
83MP0000598_abnormal_liver_morphology1.11082649
84MP0005166_decreased_susceptibility_to1.07258447
85MP0009763_increased_sensitivity_to1.06268330
86MP0009764_decreased_sensitivity_to1.06000859
87MP0003943_abnormal_hepatobiliary_system1.05104610
88MP0003566_abnormal_cell_adhesion1.04208384
89MP0004130_abnormal_muscle_cell1.01732762
90* MP0005390_skeleton_phenotype0.99598965
91MP0002006_tumorigenesis0.98432968
92MP0003690_abnormal_glial_cell0.97357134
93MP0002254_reproductive_system_inflammat0.96057960
94MP0004883_abnormal_blood_vessel0.95008603
95MP0005319_abnormal_enzyme/_coenzyme0.94507158
96MP0000858_altered_metastatic_potential0.93923627
97MP0000703_abnormal_thymus_morphology0.92065693
98MP0003866_abnormal_defecation0.91660869
99MP0002928_abnormal_bile_duct0.90979647
100MP0005164_abnormal_response_to0.90972260
101MP0005167_abnormal_blood-brain_barrier0.90946125
102MP0005451_abnormal_body_composition0.90907261
103MP0002138_abnormal_hepatobiliary_system0.85868959
104MP0001663_abnormal_digestive_system0.84756574
105MP0010234_abnormal_vibrissa_follicle0.84625949
106MP0003806_abnormal_nucleotide_metabolis0.84445166
107MP0004147_increased_porphyrin_level0.82775762
108MP0002332_abnormal_exercise_endurance0.81821999
109MP0000767_abnormal_smooth_muscle0.81671028
110MP0003795_abnormal_bone_structure0.81522764
111MP0003279_aneurysm0.80524718
112MP0000371_diluted_coat_color0.80291422
113MP0000569_abnormal_digit_pigmentation0.78563437
114MP0003183_abnormal_peptide_metabolism0.77142944
115MP0002132_abnormal_respiratory_system0.75756190
116MP0002019_abnormal_tumor_incidence0.72883398
117MP0000249_abnormal_blood_vessel0.71860360
118MP0005076_abnormal_cell_differentiation0.71856786
119MP0001348_abnormal_lacrimal_gland0.71478946
120MP0001666_abnormal_nutrient_absorption0.71448149
121MP0005023_abnormal_wound_healing0.69594977
122MP0008874_decreased_physiological_sensi0.69322332
123MP0008438_abnormal_cutaneous_collagen0.68834853
124MP0002933_joint_inflammation0.68566344
125MP0005584_abnormal_enzyme/coenzyme_acti0.68002539
126MP0009115_abnormal_fat_cell0.67794545
127MP0001542_abnormal_bone_strength0.67532160
128MP0003329_amyloid_beta_deposits0.66007960
129MP0004185_abnormal_adipocyte_glucose0.62295131
130MP0009765_abnormal_xenobiotic_induced0.60388439
131MP0000920_abnormal_myelination0.57449706
132MP0001849_ear_inflammation0.57108939

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.68618977
2Optic neuritis (HP:0100653)4.40371936
3Retrobulbar optic neuritis (HP:0100654)4.40371936
4Systemic lupus erythematosus (HP:0002725)4.19487712
5Petechiae (HP:0000967)3.97682880
6Abnormality of glycolipid metabolism (HP:0010969)3.95717796
7Abnormality of liposaccharide metabolism (HP:0010968)3.95717796
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.95717796
9Recurrent gram-negative bacterial infections (HP:0005420)3.63717318
10Loss of speech (HP:0002371)3.45457737
11Prolonged bleeding time (HP:0003010)3.43987336
12Gingival bleeding (HP:0000225)3.43751694
13Complement deficiency (HP:0004431)3.43719788
14IgM deficiency (HP:0002850)3.29146461
15Elevated erythrocyte sedimentation rate (HP:0003565)3.27207137
16Recurrent bacterial skin infections (HP:0005406)3.26105106
17Autoimmune thrombocytopenia (HP:0001973)3.19013894
18Abnormal platelet function (HP:0011869)3.17831043
19Impaired platelet aggregation (HP:0003540)3.17831043
20Recurrent abscess formation (HP:0002722)3.17761024
21Increased IgE level (HP:0003212)3.13467984
22Keratoconjunctivitis sicca (HP:0001097)3.09207433
23Deep venous thrombosis (HP:0002625)3.08211665
24Nasal polyposis (HP:0100582)3.03456651
25Epistaxis (HP:0000421)3.01374748
26Joint hemorrhage (HP:0005261)3.00287857
27Keratoconjunctivitis (HP:0001096)2.99648599
28Recurrent viral infections (HP:0004429)2.92648312
29Abnormality of complement system (HP:0005339)2.91577756
30Thrombocytosis (HP:0001894)2.89836666
31Abnormal platelet volume (HP:0011876)2.88933513
32Gingivitis (HP:0000230)2.88358805
33Abnormality of the nasal mucosa (HP:0000433)2.88109445
34Glomerulonephritis (HP:0000099)2.87832254
35Chronic obstructive pulmonary disease (HP:0006510)2.83790282
36Obstructive lung disease (HP:0006536)2.83790282
37Chronic otitis media (HP:0000389)2.83787948
38Myositis (HP:0100614)2.80254297
39Purpura (HP:0000979)2.80107706
40Gastrointestinal infarctions (HP:0005244)2.79894060
41Pulmonary infiltrates (HP:0002113)2.78773968
42Cellulitis (HP:0100658)2.78047750
43T lymphocytopenia (HP:0005403)2.77909777
44Abnormality of the fingertips (HP:0001211)2.74755227
45Chronic mucocutaneous candidiasis (HP:0002728)2.69874246
46Recurrent cutaneous fungal infections (HP:0011370)2.69874246
47Increased mean platelet volume (HP:0011877)2.69725104
48Eczematoid dermatitis (HP:0000976)2.65230929
49Menorrhagia (HP:0000132)2.63918166
50Myocardial infarction (HP:0001658)2.60110759
51Amyloidosis (HP:0011034)2.59311653
52Poikilocytosis (HP:0004447)2.57917337
53Encephalitis (HP:0002383)2.55347933
54Spontaneous hematomas (HP:0007420)2.53645050
55Abnormality of T cell number (HP:0011839)2.51846039
56Hemoptysis (HP:0002105)2.48628570
57Increased cerebral lipofuscin (HP:0011813)2.48421343
58Increased IgM level (HP:0003496)2.46882497
59Spastic diplegia (HP:0001264)2.46085093
60Hematochezia (HP:0002573)2.41840914
61Recurrent bronchitis (HP:0002837)2.36266494
62Colitis (HP:0002583)2.33153327
63Leukocytosis (HP:0001974)2.30910552
64Prolonged partial thromboplastin time (HP:0003645)2.28663162
65Cerebral aneurysm (HP:0004944)2.25750717
66Recurrent fungal infections (HP:0002841)2.24282110
67Hypergammaglobulinemia (HP:0010702)2.23788102
68Gastrointestinal inflammation (HP:0004386)2.23450606
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.21468926
70Nephritis (HP:0000123)2.21054731
71Abnormality of the common coagulation pathway (HP:0010990)2.21034769
72Inflammation of the large intestine (HP:0002037)2.19988871
73Abnormality of T cells (HP:0002843)2.19682165
74Mediastinal lymphadenopathy (HP:0100721)2.18665985
75Hypochromic anemia (HP:0001931)2.17389106
76Hypochromic microcytic anemia (HP:0004840)2.17145795
77Xanthomatosis (HP:0000991)2.16685307
78Abnormality of the intrinsic pathway (HP:0010989)2.15286678
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.13956154
80Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13789585
81Reduced antithrombin III activity (HP:0001976)2.13475565
82Recurrent skin infections (HP:0001581)2.11737343
83Gangrene (HP:0100758)2.10841681
84Abnormality of the heme biosynthetic pathway (HP:0010472)2.10248270
85Abnormality of the peritoneum (HP:0002585)2.08718916
86Episodic fever (HP:0001954)2.07966165
87Neuronal loss in central nervous system (HP:0002529)2.06814080
88Abnormality of iron homeostasis (HP:0011031)2.05606430
89Spondylolisthesis (HP:0003302)2.04999037
90Anorexia (HP:0002039)2.04744440
91Peritonitis (HP:0002586)2.04305140
92Interstitial pulmonary disease (HP:0006530)2.02585521
93Autoimmune hemolytic anemia (HP:0001890)2.01025442
94Disinhibition (HP:0000734)2.00405332
95Periodontitis (HP:0000704)1.99953174
96Acne (HP:0001061)1.99584143
97Microcytic anemia (HP:0001935)1.99493883
98Granulocytopenia (HP:0001913)1.99192954
99Polyneuropathy (HP:0001271)1.98408454
100Increased serum ferritin (HP:0003281)1.98241288
101Pulmonary embolism (HP:0002204)1.98193265
102Lymphopenia (HP:0001888)1.97952713
103Vacuolated lymphocytes (HP:0001922)1.97300526
104Acanthocytosis (HP:0001927)1.94969701
105Pustule (HP:0200039)1.94919130
106Osteomyelitis (HP:0002754)1.94880599
107Thoracic kyphosis (HP:0002942)1.94161281
108Orchitis (HP:0100796)1.94071945
109Hypercholesterolemia (HP:0003124)1.93831920
110Vasculitis (HP:0002633)1.93510128
111Intrahepatic cholestasis (HP:0001406)1.92178779
112Thin bony cortex (HP:0002753)1.92061329
113Hyperlipoproteinemia (HP:0010980)1.91725115
114Glomerulopathy (HP:0100820)1.91504762
115Polygenic inheritance (HP:0010982)1.91489192
116Joint swelling (HP:0001386)1.91294070
117Segmental peripheral demyelination/remyelination (HP:0003481)1.91274971
118Abnormality of T cell physiology (HP:0011840)1.90788912
119Chest pain (HP:0100749)1.90746558
120Panhypogammaglobulinemia (HP:0003139)1.90260045
121Emphysema (HP:0002097)1.89798218
122Aplastic anemia (HP:0001915)1.89192016
123Restrictive lung disease (HP:0002091)1.88349818
124High pitched voice (HP:0001620)1.87759326
125Urticaria (HP:0001025)1.87584421
126Mucopolysacchariduria (HP:0008155)1.87524834
127Urinary glycosaminoglycan excretion (HP:0003541)1.87524834
128Bruising susceptibility (HP:0000978)1.86688530
129Meningitis (HP:0001287)1.86613074
130Mutism (HP:0002300)1.86476367
131Prominent nose (HP:0000448)1.86374563
132Abnormal delayed hypersensitivity skin test (HP:0002963)1.85701544
133Abnormality of macrophages (HP:0004311)1.84659549
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.84098757
135Dysostosis multiplex (HP:0000943)1.84020573
136Abnormality of the prostate (HP:0008775)1.83997902
137Abnormality of the pleura (HP:0002103)1.83595136
138Neurofibrillary tangles (HP:0002185)1.83583929
139Slow saccadic eye movements (HP:0000514)1.83539760
140Arterial thrombosis (HP:0004420)1.82751904
141Hyperacusis (HP:0010780)1.79331835
142Reticulocytosis (HP:0001923)1.79303675
143Abnormality of transition element cation homeostasis (HP:0011030)1.79230395
144Abnormality of polysaccharide metabolism (HP:0011012)1.78315703
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78315703
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78315703
147Viral hepatitis (HP:0006562)1.77853508
148Hepatocellular carcinoma (HP:0001402)1.77831430
149Aortic aneurysm (HP:0004942)1.76857953
150Mitral stenosis (HP:0001718)1.76308849
151Hyperbilirubinemia (HP:0002904)1.75331780
152Gastrointestinal stroma tumor (HP:0100723)1.71607775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.70048274
2ERN13.40906083
3KIT3.23960300
4MAP4K13.18118418
5EEF2K3.09972477
6TRIB32.59494413
7TYK22.53544489
8TGFBR22.51861927
9PKN22.40928802
10CSF1R2.37021944
11TBK12.17494079
12CDK122.14383688
13SIK12.02903327
14TAOK31.97436587
15PTK61.92485436
16ZAP701.87929156
17MAP3K31.87188083
18TAOK21.81326561
19CLK11.78729819
20MAP2K31.72318693
21BTK1.61479552
22JAK31.61299829
23TAOK11.57838927
24BLK1.57725455
25MAP3K131.56976572
26MATK1.53501351
27IKBKE1.52613365
28GRK61.49952572
29FLT31.49051089
30MAP3K101.47739020
31SIK31.46435318
32PAK41.40437692
33CAMK1D1.39811374
34CDK61.35960624
35GRK71.34254118
36FGFR41.32766995
37TIE11.30757346
38CDC42BPA1.27215999
39KSR21.27018659
40TNK21.26319399
41IRAK41.23183707
42MAP3K11.20194678
43STK101.19939944
44SMG11.19875795
45FGR1.17463094
46JAK11.14413783
47LRRK21.12552686
48FGFR31.09983265
49RPS6KA41.08033571
50BCKDK1.07881353
51SYK1.05554643
52MAP3K141.04827043
53NME21.04348432
54RIPK11.03498960
55IKBKB1.03274061
56JAK21.01774527
57TEC1.00689008
58CAMK1G0.97188546
59NEK20.96404620
60PRKD20.95166225
61MARK20.95160819
62TTN0.92683306
63IRAK30.92464403
64TRPM70.89546194
65CHUK0.89530371
66MOS0.89529342
67DDR20.88646896
68CSK0.87684800
69TTK0.87563608
70BMPR20.86563942
71TXK0.86455177
72IRAK10.85063157
73CDK40.85035321
74SIK20.84658438
75FES0.82740760
76PIM10.82552200
77CAMKK20.81382194
78TGFBR10.79743640
79LYN0.79066446
80HCK0.78439362
81MAP3K70.78297248
82ITK0.76925267
83LCK0.76855272
84RIPK40.75752833
85CAMKK10.75004571
86PDK10.74120827
87EPHA30.73293524
88MAPK70.73176577
89EPHB10.73106192
90STK30.72271722
91IRAK20.71602515
92MAPK110.70881809
93PDPK10.68797896
94MAP3K110.68644733
95BMX0.66170343
96TYRO30.61096910
97ICK0.61012674
98STK40.60429992
99NEK90.58215279
100MAPKAPK30.53942887
101HIPK20.53821103
102CAMK40.53759910
103MTOR0.52676703
104DYRK30.52388666
105RPS6KB20.52327532
106SCYL20.52173189
107RPS6KA60.51286905
108MAP3K50.51008817
109ERBB20.49391308
110EGFR0.49354454
111MARK30.47394149
112MAP3K60.46926718
113DYRK1B0.46432385
114NEK10.46028004
115KDR0.45630012
116CDK70.45538538
117ATR0.42915234
118MAP3K20.42126157
119SGK30.42020188
120MAPK40.41480195
121PIM20.41006306
122PDGFRA0.40864230
123RET0.40355296
124GRK10.39507848
125PRKAA20.39473807
126TESK20.39254935
127PAK20.38601245
128YES10.37390693
129MAPKAPK20.37097262
130BRD40.35995999
131RPS6KA20.35668520
132MAPK120.33458841
133RPS6KL10.32967674
134RPS6KC10.32967674

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.13706572
2Complement and coagulation cascades_Homo sapiens_hsa046102.50321425
3Caffeine metabolism_Homo sapiens_hsa002322.46857345
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.15125880
5Allograft rejection_Homo sapiens_hsa053302.07063254
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.97410019
7Leishmaniasis_Homo sapiens_hsa051401.94597739
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88940031
9Graft-versus-host disease_Homo sapiens_hsa053321.83897067
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81781381
11B cell receptor signaling pathway_Homo sapiens_hsa046621.80341925
12Autoimmune thyroid disease_Homo sapiens_hsa053201.72921351
13Nitrogen metabolism_Homo sapiens_hsa009101.65568145
14Osteoclast differentiation_Homo sapiens_hsa043801.60631398
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58039199
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.50124070
17Tryptophan metabolism_Homo sapiens_hsa003801.48677893
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47242087
19ABC transporters_Homo sapiens_hsa020101.47210038
20Other glycan degradation_Homo sapiens_hsa005111.46040854
21Measles_Homo sapiens_hsa051621.45559739
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42703557
23Hematopoietic cell lineage_Homo sapiens_hsa046401.39964422
24Rheumatoid arthritis_Homo sapiens_hsa053231.39694770
25Acute myeloid leukemia_Homo sapiens_hsa052211.39216008
26Asthma_Homo sapiens_hsa053101.39204475
27Arginine biosynthesis_Homo sapiens_hsa002201.39165386
28Renin-angiotensin system_Homo sapiens_hsa046141.38585124
29Type I diabetes mellitus_Homo sapiens_hsa049401.34515650
30Toxoplasmosis_Homo sapiens_hsa051451.34474818
31Chemokine signaling pathway_Homo sapiens_hsa040621.33455011
32African trypanosomiasis_Homo sapiens_hsa051431.32287587
33One carbon pool by folate_Homo sapiens_hsa006701.30876408
34Pertussis_Homo sapiens_hsa051331.25390711
35Viral myocarditis_Homo sapiens_hsa054161.24642819
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24109377
37Herpes simplex infection_Homo sapiens_hsa051681.23699624
38Lysine degradation_Homo sapiens_hsa003101.21888671
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.21433727
40Selenocompound metabolism_Homo sapiens_hsa004501.21207482
41Influenza A_Homo sapiens_hsa051641.19138558
42Salmonella infection_Homo sapiens_hsa051321.19002651
43VEGF signaling pathway_Homo sapiens_hsa043701.18490745
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18461597
45Fatty acid degradation_Homo sapiens_hsa000711.15490061
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.14220566
47Chronic myeloid leukemia_Homo sapiens_hsa052201.12904923
48Antigen processing and presentation_Homo sapiens_hsa046121.12354969
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09383555
50PPAR signaling pathway_Homo sapiens_hsa033201.08460512
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.08320709
52Prolactin signaling pathway_Homo sapiens_hsa049171.07706600
53Hepatitis B_Homo sapiens_hsa051611.03892957
54Primary immunodeficiency_Homo sapiens_hsa053401.03319025
55Platelet activation_Homo sapiens_hsa046111.03160452
56Phagosome_Homo sapiens_hsa041451.02073200
57Malaria_Homo sapiens_hsa051441.01113642
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98290709
59Small cell lung cancer_Homo sapiens_hsa052220.97141825
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96094994
61Tuberculosis_Homo sapiens_hsa051520.95883779
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94869433
63Legionellosis_Homo sapiens_hsa051340.94813249
64Lysosome_Homo sapiens_hsa041420.93947357
65Apoptosis_Homo sapiens_hsa042100.92992410
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90808433
67Base excision repair_Homo sapiens_hsa034100.89772433
68Insulin resistance_Homo sapiens_hsa049310.89768936
69DNA replication_Homo sapiens_hsa030300.88859359
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87160159
71TNF signaling pathway_Homo sapiens_hsa046680.84754741
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83360611
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83290240
74Renal cell carcinoma_Homo sapiens_hsa052110.81319540
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.80256896
76Prion diseases_Homo sapiens_hsa050200.80170841
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79235247
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79080892
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77940631
80Bladder cancer_Homo sapiens_hsa052190.77578543
81Peroxisome_Homo sapiens_hsa041460.77306479
82Epstein-Barr virus infection_Homo sapiens_hsa051690.76883501
83Hepatitis C_Homo sapiens_hsa051600.76733720
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75216478
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.75197588
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74138454
87Non-small cell lung cancer_Homo sapiens_hsa052230.71901541
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71712778
89mTOR signaling pathway_Homo sapiens_hsa041500.70465950
90Pancreatic cancer_Homo sapiens_hsa052120.70089148
91Histidine metabolism_Homo sapiens_hsa003400.69826593
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68981860
93HTLV-I infection_Homo sapiens_hsa051660.68851511
94Type II diabetes mellitus_Homo sapiens_hsa049300.68275872
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.67003868
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.65007238
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64496521
98GnRH signaling pathway_Homo sapiens_hsa049120.61314025
99Endometrial cancer_Homo sapiens_hsa052130.61291413
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61109596
101Viral carcinogenesis_Homo sapiens_hsa052030.61014017
102FoxO signaling pathway_Homo sapiens_hsa040680.60210408
103Folate biosynthesis_Homo sapiens_hsa007900.59703295
104Bile secretion_Homo sapiens_hsa049760.59610357
105Starch and sucrose metabolism_Homo sapiens_hsa005000.59182143
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58287027
107Endocytosis_Homo sapiens_hsa041440.58100514
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57394054
109Notch signaling pathway_Homo sapiens_hsa043300.56552856
110Chemical carcinogenesis_Homo sapiens_hsa052040.56289294
111Pentose phosphate pathway_Homo sapiens_hsa000300.56217377
112HIF-1 signaling pathway_Homo sapiens_hsa040660.55537681
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54882415
114Retinol metabolism_Homo sapiens_hsa008300.53482656
115Prostate cancer_Homo sapiens_hsa052150.53059729
116Choline metabolism in cancer_Homo sapiens_hsa052310.52860457
117ErbB signaling pathway_Homo sapiens_hsa040120.52447891
118Systemic lupus erythematosus_Homo sapiens_hsa053220.52093023
119Inositol phosphate metabolism_Homo sapiens_hsa005620.51052463
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50838219
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50536653
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50002380
123Shigellosis_Homo sapiens_hsa051310.49363631
124MAPK signaling pathway_Homo sapiens_hsa040100.49265841
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49016167
126beta-Alanine metabolism_Homo sapiens_hsa004100.48083764
127Fat digestion and absorption_Homo sapiens_hsa049750.47098059
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44883617
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44722342
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.44100836
131Colorectal cancer_Homo sapiens_hsa052100.43820918
132MicroRNAs in cancer_Homo sapiens_hsa052060.43297587
133Amoebiasis_Homo sapiens_hsa051460.43110241
134Glioma_Homo sapiens_hsa052140.42924821
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42384306
136Proteoglycans in cancer_Homo sapiens_hsa052050.42213349
137Thyroid cancer_Homo sapiens_hsa052160.42157652
138Dorso-ventral axis formation_Homo sapiens_hsa043200.42156153
139Insulin signaling pathway_Homo sapiens_hsa049100.41946749
140N-Glycan biosynthesis_Homo sapiens_hsa005100.40997345
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40128084
142T cell receptor signaling pathway_Homo sapiens_hsa046600.39840664
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39250725
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.38810436
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38804425
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36627666

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