NDST3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.73746604
2ionotropic glutamate receptor signaling pathway (GO:0035235)5.44709086
3vocalization behavior (GO:0071625)5.43560260
4glutamate receptor signaling pathway (GO:0007215)5.30846441
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30639083
6behavioral response to nicotine (GO:0035095)5.19939615
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.11744312
8synaptic vesicle exocytosis (GO:0016079)5.11014777
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.02343422
10neuronal action potential propagation (GO:0019227)4.95810677
11pyrimidine nucleobase catabolic process (GO:0006208)4.81122639
12locomotory exploration behavior (GO:0035641)4.78259406
13response to pheromone (GO:0019236)4.76540117
14synaptic transmission, glutamatergic (GO:0035249)4.74012731
15cerebellar granule cell differentiation (GO:0021707)4.73606904
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.69882244
17neuron cell-cell adhesion (GO:0007158)4.61768845
18positive regulation of synapse maturation (GO:0090129)4.60943287
19cerebellar Purkinje cell differentiation (GO:0021702)4.56759187
20regulation of synaptic vesicle exocytosis (GO:2000300)4.51653639
21glutamate secretion (GO:0014047)4.48819399
22protein localization to synapse (GO:0035418)4.48414609
23cellular potassium ion homeostasis (GO:0030007)4.40017034
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.38596327
25neuron-neuron synaptic transmission (GO:0007270)4.37012142
26synaptic vesicle maturation (GO:0016188)4.35470353
27regulation of glutamate receptor signaling pathway (GO:1900449)4.30934765
28neurotransmitter secretion (GO:0007269)4.29910627
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.25607681
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.19401873
31long-term memory (GO:0007616)4.16980166
32regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16928023
33nucleobase catabolic process (GO:0046113)4.08819182
34gamma-aminobutyric acid transport (GO:0015812)4.07400452
35regulation of synaptic vesicle transport (GO:1902803)4.00238481
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.99203649
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.95908973
38neurotransmitter-gated ion channel clustering (GO:0072578)3.89426465
39layer formation in cerebral cortex (GO:0021819)3.87991906
40exploration behavior (GO:0035640)3.86746176
41regulation of neuronal synaptic plasticity (GO:0048168)3.86181832
42regulation of postsynaptic membrane potential (GO:0060078)3.85308439
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85198711
44synaptic vesicle endocytosis (GO:0048488)3.84377657
45axonal fasciculation (GO:0007413)3.82291606
46neuron recognition (GO:0008038)3.78573491
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77204317
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75655033
49central nervous system projection neuron axonogenesis (GO:0021952)3.72200492
50cell differentiation in hindbrain (GO:0021533)3.70398844
51regulation of synapse maturation (GO:0090128)3.69655746
52regulation of synapse structural plasticity (GO:0051823)3.64460054
53transmission of nerve impulse (GO:0019226)3.62179654
54sodium ion export (GO:0071436)3.61676790
55dendritic spine morphogenesis (GO:0060997)3.61596921
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.61124813
57regulation of neurotransmitter secretion (GO:0046928)3.61055980
58innervation (GO:0060384)3.59560458
59membrane depolarization during action potential (GO:0086010)3.56260236
60dendrite morphogenesis (GO:0048813)3.56242159
61neurotransmitter transport (GO:0006836)3.55634989
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.54113724
63postsynaptic membrane organization (GO:0001941)3.52941918
64startle response (GO:0001964)3.51586954
65positive regulation of membrane potential (GO:0045838)3.51109668
66membrane hyperpolarization (GO:0060081)3.47813641
67auditory behavior (GO:0031223)3.45388655
68membrane depolarization (GO:0051899)3.41567936
69behavioral response to ethanol (GO:0048149)3.41546098
70neuronal action potential (GO:0019228)3.39388296
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.38659843
72long-term synaptic potentiation (GO:0060291)3.31809065
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29502335
74cell migration in hindbrain (GO:0021535)3.27711926
75regulation of neurotransmitter transport (GO:0051588)3.26065451
76regulation of vesicle fusion (GO:0031338)3.25693887
77synapse assembly (GO:0007416)3.25533274
78positive regulation of synapse assembly (GO:0051965)3.25485956
79retinal ganglion cell axon guidance (GO:0031290)3.24617612
80negative regulation of dendrite development (GO:2000171)3.24597453
81prepulse inhibition (GO:0060134)3.22729420
82regulation of neurotransmitter levels (GO:0001505)3.22198417
83cochlea development (GO:0090102)3.21740648
84regulation of dendritic spine morphogenesis (GO:0061001)3.21705469
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.20353125
86behavioral defense response (GO:0002209)3.20187872
87behavioral fear response (GO:0001662)3.20187872
88regulation of synaptic plasticity (GO:0048167)3.19224937
89learning (GO:0007612)3.19212518
90neuromuscular process controlling posture (GO:0050884)3.18609285
91serotonin metabolic process (GO:0042428)3.18214297
92mechanosensory behavior (GO:0007638)3.17090749
93regulation of action potential (GO:0098900)3.15979484
94establishment of mitochondrion localization (GO:0051654)3.11948113
95protein polyglutamylation (GO:0018095)3.11471139
96proline transport (GO:0015824)3.10694783
97negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10551248
98fear response (GO:0042596)3.09360441
99presynaptic membrane organization (GO:0097090)3.08575577
100adult walking behavior (GO:0007628)3.06721212
101positive regulation of neurotransmitter secretion (GO:0001956)3.06587479
102response to auditory stimulus (GO:0010996)3.06287413
103positive regulation of potassium ion transmembrane transport (GO:1901381)3.04812421
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04776381
105response to histamine (GO:0034776)3.04650372
106synaptic transmission, cholinergic (GO:0007271)3.04597900
107axon ensheathment in central nervous system (GO:0032291)3.04161090
108central nervous system myelination (GO:0022010)3.04161090
109primary amino compound metabolic process (GO:1901160)3.04139457
110presynaptic membrane assembly (GO:0097105)3.03990553
111cell communication by electrical coupling (GO:0010644)3.02755247
112synaptic transmission (GO:0007268)3.02033041
113positive regulation of dendritic spine development (GO:0060999)3.00486889
114central nervous system neuron axonogenesis (GO:0021955)3.00000025
115potassium ion homeostasis (GO:0055075)2.95937965
116establishment of nucleus localization (GO:0040023)2.93671688
117cerebral cortex radially oriented cell migration (GO:0021799)2.93533890
118neuromuscular synaptic transmission (GO:0007274)2.93022830
119synapse organization (GO:0050808)2.92353840
120mating behavior (GO:0007617)2.90959775
121epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79497044
122spinal cord development (GO:0021510)2.77042731
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.71913195
124mitochondrion transport along microtubule (GO:0047497)2.71913195
125limb bud formation (GO:0060174)2.69515277
126neural tube formation (GO:0001841)2.69284854
127adult behavior (GO:0030534)2.67925562
128positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.67469007
129action potential (GO:0001508)2.67106272
130L-fucose catabolic process (GO:0042355)2.65218481
131fucose catabolic process (GO:0019317)2.65218481
132L-fucose metabolic process (GO:0042354)2.65218481
133positive regulation of sodium ion transmembrane transport (GO:1902307)2.62211447
134detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61720064
135positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61021023
136negative regulation of axon extension (GO:0030517)2.60456353
137retinal cone cell development (GO:0046549)2.59305713
138glycosphingolipid biosynthetic process (GO:0006688)2.57345139
139regulation of neurotransmitter uptake (GO:0051580)2.55341025
140response to amphetamine (GO:0001975)2.54187911
141regulation of voltage-gated calcium channel activity (GO:1901385)2.53314805
142neuronal ion channel clustering (GO:0045161)2.52659648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88761030
2GBX2_23144817_ChIP-Seq_PC3_Human3.83143516
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03044415
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01859081
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99787266
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.69156531
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67863457
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57144643
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57144643
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55565290
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54493893
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52379541
13REST_21632747_ChIP-Seq_MESCs_Mouse2.51087661
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.43984497
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43711251
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39532299
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.35216066
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29842719
19DROSHA_22980978_ChIP-Seq_HELA_Human2.26155487
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.19187352
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.17290893
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13917031
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12740472
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01987578
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95301161
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91969590
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89781157
28TAF15_26573619_Chip-Seq_HEK293_Human1.88062860
29SMAD4_21799915_ChIP-Seq_A2780_Human1.87419840
30AR_21572438_ChIP-Seq_LNCaP_Human1.87389671
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.86843470
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.80118721
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79770672
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77360277
35EWS_26573619_Chip-Seq_HEK293_Human1.75985056
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72501355
37IGF1R_20145208_ChIP-Seq_DFB_Human1.68722255
38P300_19829295_ChIP-Seq_ESCs_Human1.68564804
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.61616990
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56403104
41ZNF274_21170338_ChIP-Seq_K562_Hela1.55506100
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52886889
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52422439
44* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51735392
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44199070
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42016349
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.41154403
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41065554
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40924240
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40812233
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.40526940
52AR_25329375_ChIP-Seq_VCAP_Human1.40217022
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.39983188
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37912941
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.35786149
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34732804
57CBP_20019798_ChIP-Seq_JUKART_Human1.34732804
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34706038
59STAT3_23295773_ChIP-Seq_U87_Human1.34612244
60* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34395150
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33685485
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32939801
63RNF2_27304074_Chip-Seq_NSC_Mouse1.31535092
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29742932
65FUS_26573619_Chip-Seq_HEK293_Human1.27645955
66VDR_22108803_ChIP-Seq_LS180_Human1.27206206
67* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26575089
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.25261948
69TCF4_23295773_ChIP-Seq_U87_Human1.24319398
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.23602984
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22562692
72AR_19668381_ChIP-Seq_PC3_Human1.21989595
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20143834
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19168531
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19168531
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19081661
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17913017
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.17409571
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16275518
80TCF4_22108803_ChIP-Seq_LS180_Human1.15809581
81* RUNX2_22187159_ChIP-Seq_PCA_Human1.14319515
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13994302
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13810768
84TP53_16413492_ChIP-PET_HCT116_Human1.13683977
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13583127
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11755914
87* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11202393
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09943571
89* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09748240
90AHR_22903824_ChIP-Seq_MCF-7_Human1.09189744
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.09076948
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08666720
93TP53_22573176_ChIP-Seq_HFKS_Human1.07752329
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07112735
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06927076
96TP53_18474530_ChIP-ChIP_U2OS_Human1.06890916
97* P53_22387025_ChIP-Seq_ESCs_Mouse1.06789452
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.05878922
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.05716761
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.05592571
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05438235
102* JUN_21703547_ChIP-Seq_K562_Human1.04243764
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03908660
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03900332
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.03829847
106ER_23166858_ChIP-Seq_MCF-7_Human1.01840138
107BCAT_22108803_ChIP-Seq_LS180_Human1.01641439
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00827685
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00449088
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00149411
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99887898
112SOX9_26525672_Chip-Seq_HEART_Mouse0.99350902
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98369029
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95479138
115* E2F1_18555785_Chip-Seq_ESCs_Mouse0.95173885
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94273831
117* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94244557
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.94138604
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.93160881
120* PRDM14_20953172_ChIP-Seq_ESCs_Human0.92832436
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92768668
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91572303
123* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89229581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.52712006
2MP0003880_abnormal_central_pattern4.15733452
3MP0003635_abnormal_synaptic_transmissio4.04613698
4MP0009046_muscle_twitch3.75685590
5MP0004270_analgesia3.34366625
6MP0009745_abnormal_behavioral_response3.30925041
7MP0002063_abnormal_learning/memory/cond3.21038011
8MP0001968_abnormal_touch/_nociception3.08553320
9MP0002064_seizures3.05815994
10MP0002272_abnormal_nervous_system2.87102688
11* MP0002572_abnormal_emotion/affect_behav2.83232925
12MP0002734_abnormal_mechanical_nocicepti2.73074319
13MP0005423_abnormal_somatic_nervous2.68698197
14MP0001486_abnormal_startle_reflex2.59992087
15MP0002736_abnormal_nociception_after2.57390006
16MP0001984_abnormal_olfaction2.44522150
17MP0002184_abnormal_innervation2.39829642
18MP0002067_abnormal_sensory_capabilities2.38014427
19MP0002735_abnormal_chemical_nociception2.34114845
20MP0001501_abnormal_sleep_pattern2.32738182
21MP0000778_abnormal_nervous_system2.25408234
22MP0001440_abnormal_grooming_behavior2.24345889
23MP0008569_lethality_at_weaning2.19570539
24MP0006276_abnormal_autonomic_nervous1.88348116
25MP0002557_abnormal_social/conspecific_i1.85539937
26MP0002733_abnormal_thermal_nociception1.84353506
27MP0001970_abnormal_pain_threshold1.81037601
28MP0004858_abnormal_nervous_system1.77416921
29MP0001188_hyperpigmentation1.76475363
30MP0010386_abnormal_urinary_bladder1.75363104
31MP0008877_abnormal_DNA_methylation1.70735084
32MP0004145_abnormal_muscle_electrophysio1.68603846
33MP0004924_abnormal_behavior1.64456645
34MP0005386_behavior/neurological_phenoty1.64456645
35MP0000955_abnormal_spinal_cord1.60654322
36MP0004133_heterotaxia1.58774862
37MP0004811_abnormal_neuron_physiology1.58566888
38MP0005646_abnormal_pituitary_gland1.54717124
39MP0003787_abnormal_imprinting1.52530105
40MP0005551_abnormal_eye_electrophysiolog1.52087684
41MP0002882_abnormal_neuron_morphology1.51242123
42MP0004142_abnormal_muscle_tone1.48104178
43MP0001502_abnormal_circadian_rhythm1.47598092
44MP0004742_abnormal_vestibular_system1.43580423
45MP0002066_abnormal_motor_capabilities/c1.40902155
46MP0003890_abnormal_embryonic-extraembry1.40759681
47MP0005645_abnormal_hypothalamus_physiol1.36658772
48MP0003121_genomic_imprinting1.28617706
49MP0003879_abnormal_hair_cell1.27544143
50MP0002653_abnormal_ependyma_morphology1.27499662
51MP0003329_amyloid_beta_deposits1.26991153
52MP0003136_yellow_coat_color1.25411565
53MP0004885_abnormal_endolymph1.24423510
54MP0002638_abnormal_pupillary_reflex1.23203406
55MP0004043_abnormal_pH_regulation1.22843130
56MP0006072_abnormal_retinal_apoptosis1.19499676
57MP0002152_abnormal_brain_morphology1.19400872
58MP0003122_maternal_imprinting1.16570772
59MP0000569_abnormal_digit_pigmentation1.16139897
60MP0003633_abnormal_nervous_system1.13618965
61MP0003632_abnormal_nervous_system1.11901708
62MP0002909_abnormal_adrenal_gland1.11352843
63MP0003631_nervous_system_phenotype1.10753970
64MP0004215_abnormal_myocardial_fiber1.08581059
65MP0002234_abnormal_pharynx_morphology1.07864005
66MP0005499_abnormal_olfactory_system1.07527736
67MP0005394_taste/olfaction_phenotype1.07527736
68MP0002837_dystrophic_cardiac_calcinosis1.01700249
69MP0003195_calcinosis1.01304877
70MP0002752_abnormal_somatic_nervous1.00639331
71MP0001177_atelectasis0.99567668
72MP0005195_abnormal_posterior_eye0.96231718
73MP0001529_abnormal_vocalization0.95233166
74MP0005187_abnormal_penis_morphology0.94106520
75MP0002229_neurodegeneration0.92594647
76MP0002938_white_spotting0.92154179
77MP0006292_abnormal_olfactory_placode0.91576805
78MP0000751_myopathy0.90944204
79MP0000427_abnormal_hair_cycle0.90598860
80MP0009780_abnormal_chondrocyte_physiolo0.89887589
81MP0005171_absent_coat_pigmentation0.87749648
82MP0001963_abnormal_hearing_physiology0.87529677
83MP0003119_abnormal_digestive_system0.86491766
84MP0002822_catalepsy0.85925311
85MP0001299_abnormal_eye_distance/0.85632183
86MP0001905_abnormal_dopamine_level0.85551282
87MP0002069_abnormal_eating/drinking_beha0.83698977
88MP0001986_abnormal_taste_sensitivity0.83478223
89MP0004085_abnormal_heartbeat0.82402363
90MP0000631_abnormal_neuroendocrine_gland0.81812560
91MP0005084_abnormal_gallbladder_morpholo0.81501918
92MP0002102_abnormal_ear_morphology0.81457233
93MP0008872_abnormal_physiological_respon0.80451555
94MP0005253_abnormal_eye_physiology0.79019419
95MP0000647_abnormal_sebaceous_gland0.78140020
96MP0001919_abnormal_reproductive_system0.77571660
97MP0003861_abnormal_nervous_system0.77335448
98MP0002090_abnormal_vision0.76872340
99MP0002876_abnormal_thyroid_physiology0.76457152
100MP0004484_altered_response_of0.75152200
101MP0000372_irregular_coat_pigmentation0.74673622
102MP0003634_abnormal_glial_cell0.74635207
103MP0003938_abnormal_ear_development0.73919897
104MP0005409_darkened_coat_color0.71658653
105MP0003137_abnormal_impulse_conducting0.69967565
106MP0000566_synostosis0.69582862
107MP0005174_abnormal_tail_pigmentation0.68696319
108MP0008875_abnormal_xenobiotic_pharmacok0.68497525
109MP0002928_abnormal_bile_duct0.67103691
110MP0000026_abnormal_inner_ear0.66924520
111MP0000920_abnormal_myelination0.66813440
112MP0003698_abnormal_male_reproductive0.66493557
113MP0002751_abnormal_autonomic_nervous0.64116302
114MP0001943_abnormal_respiration0.61157492
115MP0010769_abnormal_survival0.60340106
116MP0008874_decreased_physiological_sensi0.60070981
117MP0010770_preweaning_lethality0.59727610
118MP0002082_postnatal_lethality0.59727610
119MP0001485_abnormal_pinna_reflex0.59289249
120MP0005535_abnormal_body_temperature0.58061241
121MP0005623_abnormal_meninges_morphology0.57895881
122MP0004147_increased_porphyrin_level0.57819921
123MP0010768_mortality/aging0.57415506
124MP0004233_abnormal_muscle_weight0.56912185
125MP0003045_fibrosis0.56596636

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.41345479
2Febrile seizures (HP:0002373)5.71465005
3Focal seizures (HP:0007359)5.69370581
4Progressive cerebellar ataxia (HP:0002073)5.61476034
5Epileptic encephalopathy (HP:0200134)5.26784289
6Atonic seizures (HP:0010819)5.17580148
7Action tremor (HP:0002345)5.16433693
8Myokymia (HP:0002411)5.07713275
9Visual hallucinations (HP:0002367)4.91644255
10Absence seizures (HP:0002121)4.65989452
11Gaze-evoked nystagmus (HP:0000640)4.11921647
12Dialeptic seizures (HP:0011146)4.10996795
13Broad-based gait (HP:0002136)4.08702080
14Generalized tonic-clonic seizures (HP:0002069)3.78446948
15Pancreatic cysts (HP:0001737)3.75869478
16Hyperventilation (HP:0002883)3.64876186
17Pancreatic fibrosis (HP:0100732)3.61395779
18Dysdiadochokinesis (HP:0002075)3.60247491
19True hermaphroditism (HP:0010459)3.53550046
20Truncal ataxia (HP:0002078)3.44168562
21Genetic anticipation (HP:0003743)3.31895311
22Hemiparesis (HP:0001269)3.31111184
23Impaired smooth pursuit (HP:0007772)3.27483009
24Molar tooth sign on MRI (HP:0002419)3.20407647
25Abnormality of midbrain morphology (HP:0002418)3.20407647
26Nephronophthisis (HP:0000090)3.18636148
27Excessive salivation (HP:0003781)3.15290130
28Drooling (HP:0002307)3.15290130
29Dysmetria (HP:0001310)3.08141457
30Scanning speech (HP:0002168)3.02478780
31Diplopia (HP:0000651)3.00972100
32Abnormality of binocular vision (HP:0011514)3.00972100
33Medial flaring of the eyebrow (HP:0010747)2.97698007
34Poor eye contact (HP:0000817)2.89130553
35Dysmetric saccades (HP:0000641)2.87826071
36Amblyopia (HP:0000646)2.87538970
37Abnormality of ocular smooth pursuit (HP:0000617)2.87271643
38Lissencephaly (HP:0001339)2.86260135
39Limb dystonia (HP:0002451)2.78512669
40Abnormal eating behavior (HP:0100738)2.70101019
41Epileptiform EEG discharges (HP:0011182)2.68712303
42Type II lissencephaly (HP:0007260)2.67793587
43Pachygyria (HP:0001302)2.66395017
44Depression (HP:0000716)2.66335695
45Abnormal social behavior (HP:0012433)2.66314592
46Impaired social interactions (HP:0000735)2.66314592
47Abnormality of the renal medulla (HP:0100957)2.64810439
48Absent speech (HP:0001344)2.63208332
49Anxiety (HP:0000739)2.60898839
50Abnormality of the renal cortex (HP:0011035)2.60865873
51Hemiplegia (HP:0002301)2.58356151
52Status epilepticus (HP:0002133)2.55413963
53EEG with generalized epileptiform discharges (HP:0011198)2.53879064
54Cystic liver disease (HP:0006706)2.53505215
55Supranuclear gaze palsy (HP:0000605)2.52305601
56Stereotypic behavior (HP:0000733)2.45156548
57Optic nerve hypoplasia (HP:0000609)2.42667770
58Impaired vibration sensation in the lower limbs (HP:0002166)2.40562469
59Intention tremor (HP:0002080)2.37200425
60Sclerocornea (HP:0000647)2.34907407
61Protruding tongue (HP:0010808)2.31607144
62Congenital stationary night blindness (HP:0007642)2.31033359
63Nephrogenic diabetes insipidus (HP:0009806)2.30672004
64Agitation (HP:0000713)2.27760609
65Renal cortical cysts (HP:0000803)2.25865663
66Hypsarrhythmia (HP:0002521)2.25090313
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24988938
68Urinary bladder sphincter dysfunction (HP:0002839)2.24731888
69Fetal akinesia sequence (HP:0001989)2.23214700
70Progressive inability to walk (HP:0002505)2.22019284
71Anencephaly (HP:0002323)2.19418522
72Genital tract atresia (HP:0001827)2.18914103
73Horizontal nystagmus (HP:0000666)2.16432663
74Abnormality of salivation (HP:0100755)2.16246641
75Mutism (HP:0002300)2.15288392
76Vaginal atresia (HP:0000148)2.13273534
77Tubular atrophy (HP:0000092)2.12776641
78Abnormal drinking behavior (HP:0030082)2.12201236
79Polydipsia (HP:0001959)2.12201236
80Postural instability (HP:0002172)2.10641279
81Polyphagia (HP:0002591)2.08841150
82Incomplete penetrance (HP:0003829)2.08205638
83Blue irides (HP:0000635)2.06916705
84Abolished electroretinogram (ERG) (HP:0000550)2.04714657
85Chronic hepatic failure (HP:0100626)2.04620599
86Aqueductal stenosis (HP:0002410)2.01653713
87Esotropia (HP:0000565)2.00455350
88Central scotoma (HP:0000603)1.99355527
89Inability to walk (HP:0002540)1.98054868
90Abnormality of the corticospinal tract (HP:0002492)1.95482114
91Retinal dysplasia (HP:0007973)1.94609583
92Volvulus (HP:0002580)1.94334375
93Exotropia (HP:0000577)1.92060731
94Congenital hepatic fibrosis (HP:0002612)1.92055720
95Pendular nystagmus (HP:0012043)1.91387244
96Postural tremor (HP:0002174)1.91195791
97Abnormality of the lower motor neuron (HP:0002366)1.90672125
98Ankle clonus (HP:0011448)1.89624289
99Gait ataxia (HP:0002066)1.87758697
100Gait imbalance (HP:0002141)1.87112581
101Pointed chin (HP:0000307)1.86855069
102Abnormality of macular pigmentation (HP:0008002)1.86598223
103Hypothermia (HP:0002045)1.85826632
104Pheochromocytoma (HP:0002666)1.84333272
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.84308937
106Annular pancreas (HP:0001734)1.83913150
107Oligodactyly (hands) (HP:0001180)1.83594289
108Abnormality of saccadic eye movements (HP:0000570)1.82166613
109Attenuation of retinal blood vessels (HP:0007843)1.82053462
110Spastic gait (HP:0002064)1.81932014
111Intestinal atresia (HP:0011100)1.80673754
112Failure to thrive in infancy (HP:0001531)1.79930614
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.79755515
114Absent/shortened dynein arms (HP:0200106)1.79755515
115Bradykinesia (HP:0002067)1.78687351
116Insidious onset (HP:0003587)1.78135698
117Termporal pattern (HP:0011008)1.78135698
118Decreased central vision (HP:0007663)1.77709913
119Postaxial hand polydactyly (HP:0001162)1.77695060
120Abnormality of the labia minora (HP:0012880)1.77416427
121Papilledema (HP:0001085)1.77361367
122Specific learning disability (HP:0001328)1.77335278
123Abnormal respiratory epithelium morphology (HP:0012253)1.76272953
124Abnormal respiratory motile cilium morphology (HP:0005938)1.76272953
125Male pseudohermaphroditism (HP:0000037)1.76250476
126Narrow forehead (HP:0000341)1.75493797
127Methylmalonic acidemia (HP:0002912)1.75012629
128Abnormal ciliary motility (HP:0012262)1.74520947
129Megalencephaly (HP:0001355)1.74302309
130Limb ataxia (HP:0002070)1.73665952
131Narrow nasal bridge (HP:0000446)1.72862451
132Poor coordination (HP:0002370)1.72023501
133Hypoventilation (HP:0002791)1.71927663
134Furrowed tongue (HP:0000221)1.71356525
135Autism (HP:0000717)1.71179783
136Impaired vibratory sensation (HP:0002495)1.71073409
137Morphological abnormality of the pyramidal tract (HP:0002062)1.70922923
138Spastic tetraplegia (HP:0002510)1.69988360
139Lower limb asymmetry (HP:0100559)1.68205109
140Generalized myoclonic seizures (HP:0002123)1.68189474
141Postaxial foot polydactyly (HP:0001830)1.67283690
142Psychosis (HP:0000709)1.67184731
143Inappropriate behavior (HP:0000719)1.67116454
144Bony spicule pigmentary retinopathy (HP:0007737)1.66604887
145Intellectual disability, severe (HP:0010864)1.65454649
146Abnormal rod and cone electroretinograms (HP:0008323)1.64346877
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.64216903
148Hypoplasia of the brainstem (HP:0002365)1.64216903
149Open mouth (HP:0000194)1.62974795
150Poor suck (HP:0002033)1.62361443
151Widely spaced teeth (HP:0000687)1.62307185
152Abnormal hair whorl (HP:0010721)1.61795928
153Neoplasm of the heart (HP:0100544)1.59746474
154Cerebral inclusion bodies (HP:0100314)1.57716920
155Congenital primary aphakia (HP:0007707)1.57212061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.01771642
2MAP3K43.20042568
3FRK3.19508394
4MAP3K92.92711815
5MARK12.89600694
6EPHA42.83415212
7CASK2.78588878
8MINK12.72309894
9MAP2K72.70880977
10RIPK42.38978411
11MAP3K122.25273279
12TNIK2.23445665
13NTRK22.18499995
14PRPF4B2.17917570
15PNCK2.11361339
16KSR12.00259394
17MAP2K41.95387600
18MAP4K21.86112340
19BMPR1B1.82533615
20DYRK21.81076137
21CAMKK21.79609162
22PAK61.75186445
23DAPK21.75172231
24TLK11.65768433
25PLK21.57579645
26MAPK131.54532312
27STK381.49575161
28CAMKK11.49118727
29GRK11.49032834
30PRKCG1.46645544
31NUAK11.45944852
32CDK51.40840910
33SIK21.35004769
34SGK21.34737552
35TRIM281.28720042
36GRK51.27780919
37KSR21.25935295
38SGK2231.20817768
39SGK4941.20817768
40DAPK11.19458418
41CAMK1G1.19137449
42BMPR21.18063209
43WNK41.17619095
44CDK191.15108719
45INSRR1.11975197
46WNK11.11207117
47STK391.09838608
48CAMK2A1.08872011
49NTRK11.04258506
50DYRK1A1.03223547
51MKNK21.01860375
52SIK30.99086498
53ADRBK20.98391776
54PTK2B0.96821502
55ZAK0.93580038
56FES0.92686987
57RIPK10.91871617
58WNK30.91736008
59CAMK2B0.88510846
60CAMK10.87119266
61SGK30.85753011
62TAOK30.85008731
63CSNK1G10.83661893
64CSNK1G30.83257464
65NME10.83175528
66CDK180.81944145
67STK110.81911888
68PRKD30.79708847
69SGK10.79035495
70CDK150.77959239
71CSNK1A1L0.77942637
72MAPK150.77514182
73CDK140.74497253
74PKN10.74202799
75UHMK10.73550526
76AKT30.72742083
77OXSR10.72392776
78PRKCH0.71093751
79BCR0.71055328
80TYRO30.69692927
81PRKCE0.69262681
82PHKG10.69038847
83PHKG20.69038847
84CAMK2D0.68792986
85MAP3K20.66388931
86ROCK20.65596776
87CDK11A0.65401064
88MAP3K130.64909789
89RET0.64222569
90CDC42BPA0.63343318
91FGFR20.61821090
92TAOK20.59680533
93ERBB30.57129990
94CAMK40.56582427
95DYRK30.56256454
96NEK60.56113629
97FGR0.55907010
98EPHB20.55723487
99MARK20.55403643
100EPHA30.54748451
101PRKG10.53879433
102PIK3CA0.53607349
103MUSK0.53434903
104FER0.52969592
105RAF10.52330503
106RPS6KA30.51018964
107ACVR1B0.48692222
108CSNK1A10.46996508
109PINK10.46858062
110CAMK2G0.46064871
111VRK10.45548886
112PRKCB0.44412379
113NLK0.43996273
114PAK30.43936883
115FYN0.43753968
116PRKACA0.43385032
117MAPKAPK50.42358513
118MAPK100.42339492
119PRKCZ0.41991936
120ARAF0.41468597
121CSNK1G20.40277022
122CDK30.40033316
123MAP2K60.39794683
124CSNK1D0.38551729
125TNK20.38352710
126MKNK10.37360537
127CSNK1E0.37040245
128ERBB20.36838923
129ADRBK10.36042870
130LIMK10.35579530
131MAPK80.35000633
132PRKCA0.34582212
133MAP2K10.33898396
134YES10.33379917
135RPS6KA40.32926370
136TXK0.31310432
137LATS10.29109235
138PRKACB0.28738875

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.68833777
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.07795211
3Synaptic vesicle cycle_Homo sapiens_hsa047213.01609933
4Glutamatergic synapse_Homo sapiens_hsa047242.94614566
5GABAergic synapse_Homo sapiens_hsa047272.83769304
6Circadian entrainment_Homo sapiens_hsa047132.81667012
7Long-term potentiation_Homo sapiens_hsa047202.80177596
8Morphine addiction_Homo sapiens_hsa050322.69948376
9Taste transduction_Homo sapiens_hsa047422.47440849
10Olfactory transduction_Homo sapiens_hsa047402.31554052
11Amphetamine addiction_Homo sapiens_hsa050312.31323625
12Salivary secretion_Homo sapiens_hsa049702.25930826
13Long-term depression_Homo sapiens_hsa047302.11312394
14Dopaminergic synapse_Homo sapiens_hsa047282.10100959
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94619266
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91041138
17Insulin secretion_Homo sapiens_hsa049111.89757680
18Renin secretion_Homo sapiens_hsa049241.81915198
19Cholinergic synapse_Homo sapiens_hsa047251.80835233
20Serotonergic synapse_Homo sapiens_hsa047261.80067909
21Calcium signaling pathway_Homo sapiens_hsa040201.77446680
22Gastric acid secretion_Homo sapiens_hsa049711.75517528
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73221985
24Oxytocin signaling pathway_Homo sapiens_hsa049211.58700486
25Butanoate metabolism_Homo sapiens_hsa006501.56540546
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53684486
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51675058
28Collecting duct acid secretion_Homo sapiens_hsa049661.44681819
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37923780
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34174187
31cAMP signaling pathway_Homo sapiens_hsa040241.33115623
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33031804
33Gap junction_Homo sapiens_hsa045401.32333471
34Linoleic acid metabolism_Homo sapiens_hsa005911.31806785
35Axon guidance_Homo sapiens_hsa043601.29012452
36Nitrogen metabolism_Homo sapiens_hsa009101.28527708
37GnRH signaling pathway_Homo sapiens_hsa049121.26341478
38Cocaine addiction_Homo sapiens_hsa050301.25650025
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23698856
40* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22960223
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22741072
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22263668
43Type II diabetes mellitus_Homo sapiens_hsa049301.16432543
44Parkinsons disease_Homo sapiens_hsa050121.15012781
45Cardiac muscle contraction_Homo sapiens_hsa042601.13708722
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12272198
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09103582
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.06388273
49Estrogen signaling pathway_Homo sapiens_hsa049151.05491781
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04171971
51Phototransduction_Homo sapiens_hsa047441.01958173
52Pancreatic secretion_Homo sapiens_hsa049720.98841790
53Ether lipid metabolism_Homo sapiens_hsa005650.98518849
54Melanogenesis_Homo sapiens_hsa049160.95722688
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92248320
56Tryptophan metabolism_Homo sapiens_hsa003800.89844084
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89709786
58ErbB signaling pathway_Homo sapiens_hsa040120.89586079
59Protein export_Homo sapiens_hsa030600.88038203
60Propanoate metabolism_Homo sapiens_hsa006400.86748000
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.86593215
62Glioma_Homo sapiens_hsa052140.85980224
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85393844
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.83308442
65Oocyte meiosis_Homo sapiens_hsa041140.80015277
66Dilated cardiomyopathy_Homo sapiens_hsa054140.78387261
67Basal transcription factors_Homo sapiens_hsa030220.77954400
68Choline metabolism in cancer_Homo sapiens_hsa052310.76551591
69Thyroid hormone synthesis_Homo sapiens_hsa049180.76440990
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.75626029
71Huntingtons disease_Homo sapiens_hsa050160.74568939
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74276233
73Vibrio cholerae infection_Homo sapiens_hsa051100.72985478
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72620147
75MAPK signaling pathway_Homo sapiens_hsa040100.71198769
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.71160396
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71075434
78Fanconi anemia pathway_Homo sapiens_hsa034600.70043225
79Steroid biosynthesis_Homo sapiens_hsa001000.67261342
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64677920
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62210915
82Circadian rhythm_Homo sapiens_hsa047100.62189454
83Alzheimers disease_Homo sapiens_hsa050100.62071680
84Basal cell carcinoma_Homo sapiens_hsa052170.61676872
85Dorso-ventral axis formation_Homo sapiens_hsa043200.61082761
86Inositol phosphate metabolism_Homo sapiens_hsa005620.60702896
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60408580
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59604143
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58314463
90Regulation of autophagy_Homo sapiens_hsa041400.56526702
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53066520
92Ras signaling pathway_Homo sapiens_hsa040140.52148208
93Rap1 signaling pathway_Homo sapiens_hsa040150.52116052
94Wnt signaling pathway_Homo sapiens_hsa043100.52053897
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51487818
96Caffeine metabolism_Homo sapiens_hsa002320.50524143
97Selenocompound metabolism_Homo sapiens_hsa004500.49982508
98Colorectal cancer_Homo sapiens_hsa052100.49965814
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48317021
100African trypanosomiasis_Homo sapiens_hsa051430.47001396
101Glucagon signaling pathway_Homo sapiens_hsa049220.46384598
102Chemical carcinogenesis_Homo sapiens_hsa052040.46377055
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45083354
104Peroxisome_Homo sapiens_hsa041460.44602912
105Endometrial cancer_Homo sapiens_hsa052130.44327467
106Mineral absorption_Homo sapiens_hsa049780.43668103
107Glycerolipid metabolism_Homo sapiens_hsa005610.43465505
108Hippo signaling pathway_Homo sapiens_hsa043900.43367769
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.42617736
110VEGF signaling pathway_Homo sapiens_hsa043700.42144045
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.40794968
112ABC transporters_Homo sapiens_hsa020100.38720929
113Retinol metabolism_Homo sapiens_hsa008300.37253990
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37243978
115Bile secretion_Homo sapiens_hsa049760.36650970
116Hedgehog signaling pathway_Homo sapiens_hsa043400.36275090
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35429517
118Alcoholism_Homo sapiens_hsa050340.35404907
119Type I diabetes mellitus_Homo sapiens_hsa049400.34627930
120mTOR signaling pathway_Homo sapiens_hsa041500.34156241
121Oxidative phosphorylation_Homo sapiens_hsa001900.32206474
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31488271
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30929439
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30451352
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27781510
126Rheumatoid arthritis_Homo sapiens_hsa053230.27512770
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26896278
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26277095
129Melanoma_Homo sapiens_hsa052180.25188213
130Endocytosis_Homo sapiens_hsa041440.22192390
131Chemokine signaling pathway_Homo sapiens_hsa040620.20837166
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20244981
133Prion diseases_Homo sapiens_hsa050200.18826803
134Ovarian steroidogenesis_Homo sapiens_hsa049130.18350080
135Renal cell carcinoma_Homo sapiens_hsa052110.18010743

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