NDUFA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the 'hydrophobic protein' (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.49525865
2* respiratory electron transport chain (GO:0022904)8.65840187
3* electron transport chain (GO:0022900)8.44914488
4ATP biosynthetic process (GO:0006754)5.41773519
5hydrogen ion transmembrane transport (GO:1902600)5.33557191
6chaperone-mediated protein transport (GO:0072321)5.21790018
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.18900461
8protein complex biogenesis (GO:0070271)5.12030018
9purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.04050044
10inner mitochondrial membrane organization (GO:0007007)4.98728978
11protein neddylation (GO:0045116)4.98135327
12purine nucleoside triphosphate biosynthetic process (GO:0009145)4.94238886
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.75594596
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.75594596
15NADH dehydrogenase complex assembly (GO:0010257)4.75594596
16proton transport (GO:0015992)4.72149656
17hydrogen transport (GO:0006818)4.63687006
18oxidative phosphorylation (GO:0006119)4.61326181
19mitochondrial respiratory chain complex assembly (GO:0033108)4.53598646
20ribosomal small subunit assembly (GO:0000028)4.47246117
21ribonucleoside triphosphate biosynthetic process (GO:0009201)4.35183040
22regulation of oxidative phosphorylation (GO:0002082)4.18351822
23energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.86292125
24ATP hydrolysis coupled proton transport (GO:0015991)3.86292125
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76160735
26maturation of SSU-rRNA (GO:0030490)3.74200871
27GTP biosynthetic process (GO:0006183)3.72017879
28dopamine transport (GO:0015872)3.71289555
29termination of RNA polymerase III transcription (GO:0006386)3.68938232
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.68938232
31nucleoside triphosphate biosynthetic process (GO:0009142)3.68843628
32platelet dense granule organization (GO:0060155)3.66954913
33translational initiation (GO:0006413)3.58485275
34ribosomal large subunit biogenesis (GO:0042273)3.56827072
35regulation of mitochondrial translation (GO:0070129)3.55110786
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.53916203
37sequestering of actin monomers (GO:0042989)3.51627617
38aerobic respiration (GO:0009060)3.44895943
39cytochrome complex assembly (GO:0017004)3.44692672
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42114894
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41246919
42negative regulation of ligase activity (GO:0051352)3.41246919
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39902521
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37146282
45respiratory chain complex IV assembly (GO:0008535)3.35705430
46ribosomal small subunit biogenesis (GO:0042274)3.34305867
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30549692
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30549692
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30284585
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30284585
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30284585
52cotranslational protein targeting to membrane (GO:0006613)3.29674154
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29209942
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29209942
55protein targeting to ER (GO:0045047)3.23519425
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22566087
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19952855
58mitochondrial transport (GO:0006839)3.19679029
59signal transduction involved in DNA integrity checkpoint (GO:0072401)3.14973777
60signal transduction involved in DNA damage checkpoint (GO:0072422)3.14973777
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13753630
62* generation of precursor metabolites and energy (GO:0006091)3.12653551
63signal transduction involved in cell cycle checkpoint (GO:0072395)3.11302796
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10587019
65protein localization to endoplasmic reticulum (GO:0070972)3.10355999
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10330521
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09361052
68water-soluble vitamin biosynthetic process (GO:0042364)3.05242167
69cellular component biogenesis (GO:0044085)3.05191199
70viral transcription (GO:0019083)3.04415119
71rRNA modification (GO:0000154)3.03517158
72protein complex disassembly (GO:0043241)2.98813875
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98466158
74signal peptide processing (GO:0006465)2.97790894
75positive regulation of ligase activity (GO:0051351)2.95895055
76negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.91752780
77macromolecular complex disassembly (GO:0032984)2.91627369
78DNA deamination (GO:0045006)2.91088014
79translational termination (GO:0006415)2.90560930
80succinate metabolic process (GO:0006105)2.90345497
81UTP biosynthetic process (GO:0006228)2.90155005
82cullin deneddylation (GO:0010388)2.90056307
83regulation of cellular respiration (GO:0043457)2.88634006
84heart process (GO:0003015)2.88284575
85heart contraction (GO:0060047)2.88284575
86protein targeting to mitochondrion (GO:0006626)2.86669811
87establishment of protein localization to mitochondrion (GO:0072655)2.84244178
88calcium-mediated signaling using intracellular calcium source (GO:0035584)2.83486794
89dopamine biosynthetic process (GO:0042416)2.83267609
90tricarboxylic acid cycle (GO:0006099)2.82742364
91intracellular protein transmembrane import (GO:0044743)2.82034829
92ribonucleoside monophosphate biosynthetic process (GO:0009156)2.81193446
93detection of calcium ion (GO:0005513)2.79177816
94nucleoside monophosphate biosynthetic process (GO:0009124)2.78726664
95aldehyde catabolic process (GO:0046185)2.77055454
96regulation of cellular amine metabolic process (GO:0033238)2.75809448
97protein localization to mitochondrion (GO:0070585)2.75801447
98pseudouridine synthesis (GO:0001522)2.74610374
99purine nucleoside monophosphate biosynthetic process (GO:0009127)2.74409518
100purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.74409518
101regulation of dopamine metabolic process (GO:0042053)2.72836186
102regulation of catecholamine metabolic process (GO:0042069)2.72836186
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72680985
104protein-cofactor linkage (GO:0018065)2.70735645
105peptidyl-histidine modification (GO:0018202)2.69454423
106cellular respiration (GO:0045333)2.63126895
107quinone biosynthetic process (GO:1901663)2.62935600
108ubiquinone biosynthetic process (GO:0006744)2.62935600
109neuron cell-cell adhesion (GO:0007158)2.62737050
110guanosine-containing compound biosynthetic process (GO:1901070)2.61756597
111substantia nigra development (GO:0021762)2.60663468
112nucleoside diphosphate phosphorylation (GO:0006165)2.57906791
113phagosome maturation (GO:0090382)2.52410074
114UTP metabolic process (GO:0046051)2.52305900
115sarcoplasmic reticulum calcium ion transport (GO:0070296)2.52036688
116purine nucleoside biosynthetic process (GO:0042451)2.51600449
117purine ribonucleoside biosynthetic process (GO:0046129)2.51600449
118ubiquinone metabolic process (GO:0006743)2.46569443
119catecholamine transport (GO:0051937)2.44378885
120mitochondrion morphogenesis (GO:0070584)2.40915032
121regulation of protein kinase A signaling (GO:0010738)2.39998311
122proteasome assembly (GO:0043248)2.37968827
123regulation of cell communication by electrical coupling (GO:0010649)2.37948210
124translation (GO:0006412)2.37801039
125transferrin transport (GO:0033572)2.37645172
126CTP biosynthetic process (GO:0006241)2.37539467
127CTP metabolic process (GO:0046036)2.37539467
128viral life cycle (GO:0019058)2.32828932
129protein localization to cilium (GO:0061512)2.30375981
130cellular protein complex disassembly (GO:0043624)2.29382360
131regulation of relaxation of muscle (GO:1901077)2.25778673
132NADH metabolic process (GO:0006734)2.25490833
133intracellular protein transmembrane transport (GO:0065002)2.22670206
134regulation of cellular amino acid metabolic process (GO:0006521)2.21550466
135ferric iron transport (GO:0015682)2.21023315
136trivalent inorganic cation transport (GO:0072512)2.21023315
137translational elongation (GO:0006414)2.20793948
138negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.20503521
139negative regulation of calcium ion transmembrane transport (GO:1903170)2.20503521
140protein targeting to membrane (GO:0006612)2.19446225
141positive regulation of action potential (GO:0045760)2.18676851
142mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.5619891
143ATP synthesis coupled proton transport (GO:0015986)10.0931384
144energy coupled proton transport, down electrochemical gradient (GO:0015985)10.0931384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.74569001
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.45821030
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.96784077
4VDR_22108803_ChIP-Seq_LS180_Human2.94322756
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89280197
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.72445368
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.54191451
8TAF15_26573619_Chip-Seq_HEK293_Human2.49336702
9VDR_23849224_ChIP-Seq_CD4+_Human2.47362511
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.47002295
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31565972
12GBX2_23144817_ChIP-Seq_PC3_Human2.28871427
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.26146257
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24170064
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22669896
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21593892
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20014393
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10697544
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06801344
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.05510704
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04887103
22FOXP3_21729870_ChIP-Seq_TREG_Human1.99818714
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96959169
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94834115
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92431850
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89841117
27MYC_18940864_ChIP-ChIP_HL60_Human1.87581395
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87230080
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87053958
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85952784
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.77095410
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75382808
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74659185
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74141109
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72892295
36* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70116635
37TTF2_22483619_ChIP-Seq_HELA_Human1.69132806
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68309841
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68124753
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67880111
41DCP1A_22483619_ChIP-Seq_HELA_Human1.66335408
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.64406379
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63039754
44P300_19829295_ChIP-Seq_ESCs_Human1.60937111
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57454614
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.56166151
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55848963
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55738681
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54022641
50FUS_26573619_Chip-Seq_HEK293_Human1.52428546
51XRN2_22483619_ChIP-Seq_HELA_Human1.50534262
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48055295
53* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47407534
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46157785
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45765555
56EWS_26573619_Chip-Seq_HEK293_Human1.44898416
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.44855886
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44172345
59ER_23166858_ChIP-Seq_MCF-7_Human1.42944007
60IGF1R_20145208_ChIP-Seq_DFB_Human1.41976002
61GABP_19822575_ChIP-Seq_HepG2_Human1.41447465
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.41089718
63TP53_22573176_ChIP-Seq_HFKS_Human1.40169387
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37662211
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36597646
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36052805
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34990944
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34753998
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34074451
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33598586
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.33212011
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28796226
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28629509
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28212145
75EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28212145
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.27374425
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27246113
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26859145
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26323111
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25887249
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25299702
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.25156160
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24462668
84REST_21632747_ChIP-Seq_MESCs_Mouse1.23765671
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22935254
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19793007
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19672444
88HTT_18923047_ChIP-ChIP_STHdh_Human1.18106525
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.18000252
90E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15365668
91IRF1_19129219_ChIP-ChIP_H3396_Human1.15190211
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14442642
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13355667
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13083154
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11992604
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11245495
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.10839094
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09317696
99* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09022306
100* FOXA1_25329375_ChIP-Seq_VCAP_Human1.09022306
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08565957
102ELK1_19687146_ChIP-ChIP_HELA_Human1.07291095
103ZNF274_21170338_ChIP-Seq_K562_Hela1.05892580
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05456379
105RNF2_27304074_Chip-Seq_NSC_Mouse1.05359154
106SMAD4_21799915_ChIP-Seq_A2780_Human1.04390230
107AR_20517297_ChIP-Seq_VCAP_Human1.04291563
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03426325
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03189111
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01919114
111ERG_20517297_ChIP-Seq_VCAP_Human1.01247310
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.00584593
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99335656
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99195129
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99076216
116BCAT_22108803_ChIP-Seq_LS180_Human0.98260430
117REST_18959480_ChIP-ChIP_MESCs_Mouse0.98227835
118SOX2_19829295_ChIP-Seq_ESCs_Human0.97908365
119NANOG_19829295_ChIP-Seq_ESCs_Human0.97908365
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97556579
121ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97302586
122TAL1_26923725_Chip-Seq_HPCs_Mouse0.96521262
123REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94111408
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93856168
125NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93408412
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.92493526
127STAT3_18555785_Chip-Seq_ESCs_Mouse0.92303852
128P53_22387025_ChIP-Seq_ESCs_Mouse0.91908627
129YY1_21170310_ChIP-Seq_MESCs_Mouse0.91593068
130JUN_21703547_ChIP-Seq_K562_Human0.90948572
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90825132
132GATA3_21878914_ChIP-Seq_MCF-7_Human0.90759641
133CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90615911
134SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90441301
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90014437
136SOX2_16153702_ChIP-ChIP_HESCs_Human0.89741010
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88587951
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87689876
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87401084
140CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85027155
141SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84940747
142NCOR_22424771_ChIP-Seq_293T_Human0.84875627
143SOX2_18555785_Chip-Seq_ESCs_Mouse0.84672717
144NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84581739
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84581739
146CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84257037
147SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83985258
148CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82267663
149RBPJ_21746931_ChIP-Seq_IB4_Human0.82086479
150NANOG_16153702_ChIP-ChIP_HESCs_Human0.81872750
151PHF8_20622853_ChIP-Seq_HELA_Human0.79249028
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77777450
153MYC_19829295_ChIP-Seq_ESCs_Human0.77155317

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.51768979
2MP0003880_abnormal_central_pattern4.10571566
3MP0001529_abnormal_vocalization3.34182354
4MP0009379_abnormal_foot_pigmentation3.05962463
5MP0006276_abnormal_autonomic_nervous3.01162233
6MP0003806_abnormal_nucleotide_metabolis2.66646348
7MP0003646_muscle_fatigue2.62239023
8MP0004147_increased_porphyrin_level2.47383361
9MP0001905_abnormal_dopamine_level2.47061532
10MP0006036_abnormal_mitochondrial_physio2.41113226
11MP0010386_abnormal_urinary_bladder2.30208390
12MP0002638_abnormal_pupillary_reflex2.10204348
13MP0002938_white_spotting2.09425167
14MP0003011_delayed_dark_adaptation2.06086861
15MP0005379_endocrine/exocrine_gland_phen2.05666298
16MP0004215_abnormal_myocardial_fiber1.97824114
17MP0002736_abnormal_nociception_after1.96562553
18MP0001968_abnormal_touch/_nociception1.96048187
19MP0000751_myopathy1.91984087
20MP0006292_abnormal_olfactory_placode1.91037223
21MP0004142_abnormal_muscle_tone1.89952156
22MP0002163_abnormal_gland_morphology1.85689673
23MP0006035_abnormal_mitochondrial_morpho1.84256279
24MP0009745_abnormal_behavioral_response1.84061259
25MP0004043_abnormal_pH_regulation1.82760945
26MP0001440_abnormal_grooming_behavior1.80414625
27MP0002876_abnormal_thyroid_physiology1.78621570
28MP0000749_muscle_degeneration1.75983543
29MP0002272_abnormal_nervous_system1.74500356
30MP0009046_muscle_twitch1.72910545
31MP0004036_abnormal_muscle_relaxation1.70958107
32MP0002064_seizures1.70798262
33MP0008995_early_reproductive_senescence1.68481507
34MP0005645_abnormal_hypothalamus_physiol1.68053402
35MP0003195_calcinosis1.67781895
36MP0002735_abnormal_chemical_nociception1.67026767
37MP0002822_catalepsy1.64993706
38MP0001984_abnormal_olfaction1.64817768
39MP0001501_abnormal_sleep_pattern1.60844309
40MP0005535_abnormal_body_temperature1.60130040
41MP0008058_abnormal_DNA_repair1.58220656
42MP0000013_abnormal_adipose_tissue1.58039761
43MP0003136_yellow_coat_color1.57650219
44MP0008875_abnormal_xenobiotic_pharmacok1.56465927
45MP0002332_abnormal_exercise_endurance1.55968735
46MP0002734_abnormal_mechanical_nocicepti1.52067950
47MP0003635_abnormal_synaptic_transmissio1.51641149
48MP0002572_abnormal_emotion/affect_behav1.48818044
49MP0001485_abnormal_pinna_reflex1.48490096
50MP0004924_abnormal_behavior1.45860818
51MP0005386_behavior/neurological_phenoty1.45860818
52MP0001970_abnormal_pain_threshold1.45679661
53MP0005332_abnormal_amino_acid1.45591160
54MP0002234_abnormal_pharynx_morphology1.42251818
55MP0003786_premature_aging1.41407682
56MP0002102_abnormal_ear_morphology1.36543714
57MP0005423_abnormal_somatic_nervous1.35590464
58MP0005646_abnormal_pituitary_gland1.35221828
59MP0003122_maternal_imprinting1.34132073
60MP0008877_abnormal_DNA_methylation1.33984058
61MP0004145_abnormal_muscle_electrophysio1.33596858
62MP0003137_abnormal_impulse_conducting1.30870091
63MP0005330_cardiomyopathy1.30589521
64MP0006072_abnormal_retinal_apoptosis1.29889922
65MP0002733_abnormal_thermal_nociception1.29866468
66MP0004019_abnormal_vitamin_homeostasis1.28793567
67MP0001486_abnormal_startle_reflex1.25617032
68MP0002972_abnormal_cardiac_muscle1.24341553
69MP0002063_abnormal_learning/memory/cond1.24280306
70MP0002067_abnormal_sensory_capabilities1.23823355
71MP0000372_irregular_coat_pigmentation1.22494255
72MP0005409_darkened_coat_color1.21946488
73MP0004484_altered_response_of1.21621430
74MP0003186_abnormal_redox_activity1.20560001
75MP0002139_abnormal_hepatobiliary_system1.20218851
76MP0004084_abnormal_cardiac_muscle1.18335899
77MP0003718_maternal_effect1.14658694
78MP0005084_abnormal_gallbladder_morpholo1.14282779
79MP0004133_heterotaxia1.12819544
80MP0004085_abnormal_heartbeat1.12138960
81MP0003724_increased_susceptibility_to1.11836795
82MP0004885_abnormal_endolymph1.11073850
83MP0001188_hyperpigmentation1.10882295
84MP0000538_abnormal_urinary_bladder1.08121448
85MP0005075_abnormal_melanosome_morpholog1.04687355
86MP0004742_abnormal_vestibular_system1.04309698
87MP0008872_abnormal_physiological_respon1.03827761
88MP0000230_abnormal_systemic_arterial1.03441413
89MP0005636_abnormal_mineral_homeostasis1.03324527
90MP0008789_abnormal_olfactory_epithelium1.03288746
91MP0005620_abnormal_muscle_contractility1.02322197
92MP0003787_abnormal_imprinting1.01156590
93MP0004270_analgesia1.01127466
94MP0001727_abnormal_embryo_implantation0.99406038
95MP0001919_abnormal_reproductive_system0.96811750
96MP0002184_abnormal_innervation0.96672645
97MP0002095_abnormal_skin_pigmentation0.94923454
98MP0002693_abnormal_pancreas_physiology0.94803493
99MP0002557_abnormal_social/conspecific_i0.93715914
100MP0005389_reproductive_system_phenotype0.93051996
101MP0001986_abnormal_taste_sensitivity0.92565570
102MP0001756_abnormal_urination0.91769954
103MP0001664_abnormal_digestion0.90602760
104MP0002160_abnormal_reproductive_system0.89980994
105MP0005551_abnormal_eye_electrophysiolog0.89565095
106MP0002148_abnormal_hypersensitivity_rea0.88733858
107MP0002277_abnormal_respiratory_mucosa0.86027027
108MP0002090_abnormal_vision0.85909834
109MP0002653_abnormal_ependyma_morphology0.85247019
110MP0001502_abnormal_circadian_rhythm0.84670323
111MP0002106_abnormal_muscle_physiology0.84420479
112MP0005365_abnormal_bile_salt0.83323542
113MP0008775_abnormal_heart_ventricle0.81457537
114MP0003283_abnormal_digestive_organ0.81144378
115MP0005085_abnormal_gallbladder_physiolo0.78915928
116MP0005266_abnormal_metabolism0.78480751
117MP0000026_abnormal_inner_ear0.78333635
118MP0002909_abnormal_adrenal_gland0.78095732
119MP0005253_abnormal_eye_physiology0.76229992
120MP0003959_abnormal_lean_body0.76121670
121MP0005410_abnormal_fertilization0.75951357
122MP0000631_abnormal_neuroendocrine_gland0.75717989
123MP0005171_absent_coat_pigmentation0.75693347
124MP0001764_abnormal_homeostasis0.74778102
125MP0001944_abnormal_pancreas_morphology0.74668862
126MP0010030_abnormal_orbit_morphology0.74586274
127MP0003121_genomic_imprinting0.72892012
128MP0002066_abnormal_motor_capabilities/c0.72775571
129MP0001544_abnormal_cardiovascular_syste0.72524501
130MP0005385_cardiovascular_system_phenoty0.72524501
131MP0005174_abnormal_tail_pigmentation0.72220615
132MP0009697_abnormal_copulation0.71292622
133MP0005377_hearing/vestibular/ear_phenot0.71089004
134MP0003878_abnormal_ear_physiology0.71089004
135MP0002210_abnormal_sex_determination0.70475266
136MP0005369_muscle_phenotype0.69656113
137MP0000920_abnormal_myelination0.69507960
138MP0000778_abnormal_nervous_system0.68907023
139MP0005165_increased_susceptibility_to0.68609475
140MP0001963_abnormal_hearing_physiology0.68240141
141MP0005376_homeostasis/metabolism_phenot0.68097767
142MP0005408_hypopigmentation0.67266575

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)7.65123435
2* Abnormal mitochondria in muscle tissue (HP:0008316)6.96744091
3* Mitochondrial inheritance (HP:0001427)6.49871843
4* Progressive macrocephaly (HP:0004481)6.47780224
5* Acute encephalopathy (HP:0006846)6.31783501
6* Increased CSF lactate (HP:0002490)5.44021904
7Hepatocellular necrosis (HP:0001404)5.36380179
8Increased hepatocellular lipid droplets (HP:0006565)5.13074909
9Hepatic necrosis (HP:0002605)5.04750777
10Lipid accumulation in hepatocytes (HP:0006561)4.73307501
11Renal Fanconi syndrome (HP:0001994)4.63545942
12* Cerebral edema (HP:0002181)4.45444648
13Increased intramyocellular lipid droplets (HP:0012240)4.19248875
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.14425915
15* Optic disc pallor (HP:0000543)3.92655478
16* Exercise intolerance (HP:0003546)3.90881884
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.78754407
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.78754407
19* Lactic acidosis (HP:0003128)3.76460300
20* Respiratory failure (HP:0002878)3.73868861
21Increased muscle lipid content (HP:0009058)3.72346388
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.69998700
233-Methylglutaconic aciduria (HP:0003535)3.55825313
24Exertional dyspnea (HP:0002875)3.41105201
25* Leukodystrophy (HP:0002415)3.33476422
26Neuroendocrine neoplasm (HP:0100634)3.33289018
27Congenital, generalized hypertrichosis (HP:0004540)3.24684806
28Abnormality of renal resorption (HP:0011038)3.22627396
29Pheochromocytoma (HP:0002666)3.22449732
30Reticulocytopenia (HP:0001896)3.20484660
31Increased serum lactate (HP:0002151)3.08103576
32Respiratory difficulties (HP:0002880)2.97835953
33Increased serum pyruvate (HP:0003542)2.96163107
34Abnormality of glycolysis (HP:0004366)2.96163107
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.88387918
36Glycosuria (HP:0003076)2.80999030
37Abnormality of urine glucose concentration (HP:0011016)2.80999030
38Hypothermia (HP:0002045)2.77174941
39Muscle hypertrophy of the lower extremities (HP:0008968)2.76564359
40Calf muscle hypertrophy (HP:0008981)2.70809629
41* X-linked dominant inheritance (HP:0001423)2.67379379
42Hyperphosphaturia (HP:0003109)2.64803870
43Abnormality of cells of the erythroid lineage (HP:0012130)2.61651964
44Pancreatic fibrosis (HP:0100732)2.58384874
45Pancreatic cysts (HP:0001737)2.56745646
46True hermaphroditism (HP:0010459)2.43287152
47Type I transferrin isoform profile (HP:0003642)2.39669421
48Palpitations (HP:0001962)2.35870011
49Conjunctival hamartoma (HP:0100780)2.35672848
50Parakeratosis (HP:0001036)2.35467532
51Molar tooth sign on MRI (HP:0002419)2.34505795
52Abnormality of midbrain morphology (HP:0002418)2.34505795
53Abnormal pupillary function (HP:0007686)2.31627561
54* Lethargy (HP:0001254)2.28092978
55Abnormal number of erythroid precursors (HP:0012131)2.23879255
56Aplastic anemia (HP:0001915)2.21822517
57Abnormal urine phosphate concentration (HP:0012599)2.19125331
58CNS demyelination (HP:0007305)2.17291542
59Pallor (HP:0000980)2.16738497
60Sudden death (HP:0001699)2.15010372
61Focal motor seizures (HP:0011153)2.13281423
62Renal tubular dysfunction (HP:0000124)2.12167323
63Medial flaring of the eyebrow (HP:0010747)2.08676856
64Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08255107
65Cerebral hemorrhage (HP:0001342)2.07572110
66Sclerocornea (HP:0000647)2.05226479
67Limb dystonia (HP:0002451)1.98844627
68Abnormal ciliary motility (HP:0012262)1.98442615
69Generalized aminoaciduria (HP:0002909)1.98042298
70Methylmalonic aciduria (HP:0012120)1.95871812
71Nephronophthisis (HP:0000090)1.95175935
72Methylmalonic acidemia (HP:0002912)1.92686918
73Emotional lability (HP:0000712)1.92191390
74Congenital primary aphakia (HP:0007707)1.90217489
75Congenital ichthyosiform erythroderma (HP:0007431)1.90161846
76Gait imbalance (HP:0002141)1.87962583
77Ketoacidosis (HP:0001993)1.87402563
78* Vomiting (HP:0002013)1.83434009
79Anxiety (HP:0000739)1.80944451
80Degeneration of anterior horn cells (HP:0002398)1.80586260
81Abnormality of the anterior horn cell (HP:0006802)1.80586260
82Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79925181
83Dicarboxylic aciduria (HP:0003215)1.79925181
84Oral leukoplakia (HP:0002745)1.77481348
85Nuclear cataract (HP:0100018)1.77178935
86Pancytopenia (HP:0001876)1.76969895
87Abnormality of the calf musculature (HP:0001430)1.76943567
88Male pseudohermaphroditism (HP:0000037)1.75359162
89Nausea (HP:0002018)1.75338019
90Abnormal respiratory motile cilium morphology (HP:0005938)1.73765536
91Abnormal respiratory epithelium morphology (HP:0012253)1.73765536
92Progressive inability to walk (HP:0002505)1.73764444
93Abnormal hemoglobin (HP:0011902)1.73720702
94Large for gestational age (HP:0001520)1.72709931
95Myokymia (HP:0002411)1.72414455
96Nephrogenic diabetes insipidus (HP:0009806)1.71369848
97Abnormal protein N-linked glycosylation (HP:0012347)1.69503771
98Abnormal protein glycosylation (HP:0012346)1.69503771
99Abnormal glycosylation (HP:0012345)1.69503771
100Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69503771
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68428765
102Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67696310
103Prolonged QT interval (HP:0001657)1.67518998
104Macrocytic anemia (HP:0001972)1.67457361
105Poor suck (HP:0002033)1.67167985
106Gliosis (HP:0002171)1.66700936
107Aplasia/hypoplasia of the uterus (HP:0008684)1.66074689
108Renal cortical cysts (HP:0000803)1.64012158
109Neoplasm of head and neck (HP:0012288)1.62385614
110Esophageal neoplasm (HP:0100751)1.62385614
111Hyperventilation (HP:0002883)1.62230761
112Exercise-induced myalgia (HP:0003738)1.62022769
113Hyperglycinemia (HP:0002154)1.62018908
114Congenital stationary night blindness (HP:0007642)1.61935708
115Zonular cataract (HP:0010920)1.60142710
116Syncope (HP:0001279)1.59935507
117Tinnitus (HP:0000360)1.59780550
118Abnormality of the renal cortex (HP:0011035)1.59274719
119Left ventricular hypertrophy (HP:0001712)1.59177086
120Ragged-red muscle fibers (HP:0003200)1.58464468
121Type 2 muscle fiber atrophy (HP:0003554)1.58136313
122Metabolic acidosis (HP:0001942)1.57816860
123Abnormality of vitamin B metabolism (HP:0004340)1.56767914
124Atonic seizures (HP:0010819)1.55786357
125Abnormal respiratory motile cilium physiology (HP:0012261)1.54706464
126Abnormality of placental membranes (HP:0011409)1.54551111
127Amniotic constriction ring (HP:0009775)1.54551111
128Absence seizures (HP:0002121)1.53712990
129Furrowed tongue (HP:0000221)1.53634785
130Vaginal atresia (HP:0000148)1.53587514
131Delayed CNS myelination (HP:0002188)1.53232092
132Hyperalaninemia (HP:0003348)1.51725304
133Retinal dysplasia (HP:0007973)1.51634666
134Genital tract atresia (HP:0001827)1.50454532
135* Blindness (HP:0000618)1.50243045
136Delayed gross motor development (HP:0002194)1.49992850
137Abnormal hair whorl (HP:0010721)1.49319128
138Abnormality of the vocal cords (HP:0008777)1.49297971
139Hypoglycemic coma (HP:0001325)1.48868523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.83067960
2MAP3K123.56414913
3NME13.22381410
4MYLK3.16516717
5NME23.03854273
6CASK2.53603669
7ARAF2.48054757
8GRK72.45547966
9MST42.39025398
10STK162.20379387
11MUSK2.18425816
12BUB12.17076571
13ZAK2.15798122
14WNK42.04031114
15MAP2K71.99896393
16ADRBK21.90587218
17OBSCN1.86458193
18MAP4K21.86323968
19BMPR21.85080043
20PNCK1.81000366
21STK391.80014312
22GRK51.79512739
23RIPK41.72565966
24PBK1.72214669
25NUAK11.67039786
26TAF11.66542306
27BMPR1B1.62776059
28MAPK151.43579989
29OXSR11.40955134
30NTRK31.39521239
31BCKDK1.35123368
32WNK31.34029876
33TNIK1.32276592
34BCR1.32005334
35EIF2AK11.21474728
36NEK11.19066241
37INSRR1.18133125
38PIK3CG1.16937690
39MAP3K41.15976727
40IRAK31.15808322
41TESK11.15403671
42CAMK2D1.15200386
43CAMK2A1.14486515
44MAPK131.11869749
45CDK191.11037372
46TRIM281.10996721
47PLK31.09067438
48CSNK1G21.08673069
49ADRBK11.04624698
50CDC71.04356481
51PRKCE1.01512338
52CAMK2B1.01406948
53WEE10.98666058
54PIK3CA0.98172510
55PHKG10.97883048
56PHKG20.97883048
57PLK20.97214070
58EPHA40.95812168
59VRK10.95751034
60CSNK1G10.94226411
61MAPKAPK50.94026909
62UHMK10.93846105
63ABL20.93651332
64MARK10.93382519
65LIMK10.92790364
66IRAK40.91689477
67BRAF0.87734534
68EIF2AK30.87452242
69MAP2K40.87014099
70DYRK20.84919216
71CAMK2G0.83410065
72SRPK10.83394588
73PINK10.79806957
74PIM20.79537460
75DYRK30.79428505
76PKN10.79241419
77PRKACA0.74632022
78FGR0.74481399
79PAK30.72950290
80CSNK1A1L0.72887524
81CCNB10.71985846
82KDR0.71971939
83DAPK30.71629363
84STK240.71487044
85CDK80.67926020
86CSNK2A20.66712609
87MST1R0.66163437
88ERBB30.65657318
89RPS6KA50.64469649
90PLK40.64424594
91TAOK30.61447944
92IRAK20.60915196
93CSNK2A10.60430019
94IRAK10.57820957
95FRK0.56369502
96CSNK1G30.56247442
97TESK20.56153764
98ILK0.55737876
99PDK40.53809823
100PDK30.53809823
101MAP2K60.53371141
102PDK20.52717860
103PRKCG0.51227623
104PLK10.51162886
105CHEK20.50553106
106NTRK20.50524714
107MINK10.49639403
108AURKA0.48437251
109PRKCQ0.46931997
110PTK2B0.46590361
111AURKB0.46414149
112CSNK1A10.45967741
113IKBKB0.45620488
114MAPK120.45609449
115TSSK60.45276796
116MAPKAPK30.44807288
117MAP3K140.44460316
118TLK10.44019608
119CDK50.43944375
120SYK0.43616485
121CAMKK20.43176270
122NTRK10.42992799
123TXK0.42824390
124EPHB20.42180194
125PRKCI0.40929375
126EIF2AK20.40511833
127STK40.40202634
128PASK0.40181290
129TEC0.38261476
130ROCK20.38147097
131MAP3K90.37428382
132MOS0.37376422
133PRKG10.37177887
134DAPK10.37169543
135MAPK40.36329137
136GRK10.36187520
137PRKCD0.36114436
138MAP3K130.35861898
139PRKCA0.35802405
140TNK20.35188701
141FES0.34479292
142YES10.33469572
143MAP3K20.32108213

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.98880176
2Parkinsons disease_Homo sapiens_hsa050125.88419327
3Alzheimers disease_Homo sapiens_hsa050104.60260935
4Huntingtons disease_Homo sapiens_hsa050164.05821862
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.88296995
6Cardiac muscle contraction_Homo sapiens_hsa042603.27401509
7Protein export_Homo sapiens_hsa030603.08465723
8Ribosome_Homo sapiens_hsa030102.89831702
9Proteasome_Homo sapiens_hsa030502.28965911
10Collecting duct acid secretion_Homo sapiens_hsa049662.20873047
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07972654
12Sulfur metabolism_Homo sapiens_hsa009201.90245477
13Homologous recombination_Homo sapiens_hsa034401.61093492
14Vibrio cholerae infection_Homo sapiens_hsa051101.51994673
15Fatty acid elongation_Homo sapiens_hsa000621.48797256
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43684083
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42590900
18Mismatch repair_Homo sapiens_hsa034301.38554126
19Propanoate metabolism_Homo sapiens_hsa006401.30773211
20Nicotine addiction_Homo sapiens_hsa050331.26401613
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21992526
22RNA polymerase_Homo sapiens_hsa030201.16949633
23Rheumatoid arthritis_Homo sapiens_hsa053231.13661260
24Basal transcription factors_Homo sapiens_hsa030221.04700947
25Pyruvate metabolism_Homo sapiens_hsa006201.04431860
26Nitrogen metabolism_Homo sapiens_hsa009101.02779858
27Synaptic vesicle cycle_Homo sapiens_hsa047211.01271582
28DNA replication_Homo sapiens_hsa030300.98674625
29Maturity onset diabetes of the young_Homo sapiens_hsa049500.97485391
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97223547
31Spliceosome_Homo sapiens_hsa030400.95674987
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94733978
33Nucleotide excision repair_Homo sapiens_hsa034200.93289236
34SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93279166
35Serotonergic synapse_Homo sapiens_hsa047260.93039971
36RNA degradation_Homo sapiens_hsa030180.89849415
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87996285
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87680795
39Phenylalanine metabolism_Homo sapiens_hsa003600.87183278
40Tyrosine metabolism_Homo sapiens_hsa003500.84893862
41Sulfur relay system_Homo sapiens_hsa041220.84712568
42Graft-versus-host disease_Homo sapiens_hsa053320.84556715
43Butanoate metabolism_Homo sapiens_hsa006500.83752866
44One carbon pool by folate_Homo sapiens_hsa006700.82093252
45Taste transduction_Homo sapiens_hsa047420.81982813
46* Metabolic pathways_Homo sapiens_hsa011000.81242432
47Fanconi anemia pathway_Homo sapiens_hsa034600.80368762
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79257199
49Type I diabetes mellitus_Homo sapiens_hsa049400.77968130
50GABAergic synapse_Homo sapiens_hsa047270.74863608
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67777251
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64801880
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63960814
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.61856600
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.60940918
56Phagosome_Homo sapiens_hsa041450.60784114
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59380296
58Peroxisome_Homo sapiens_hsa041460.59283398
59Arachidonic acid metabolism_Homo sapiens_hsa005900.59113747
60Morphine addiction_Homo sapiens_hsa050320.58257723
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57690672
62Mineral absorption_Homo sapiens_hsa049780.57361038
63Base excision repair_Homo sapiens_hsa034100.52961687
64Linoleic acid metabolism_Homo sapiens_hsa005910.52104892
65Phototransduction_Homo sapiens_hsa047440.52049495
66Amphetamine addiction_Homo sapiens_hsa050310.51509432
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50680767
68Ether lipid metabolism_Homo sapiens_hsa005650.50268210
69Histidine metabolism_Homo sapiens_hsa003400.49631182
70Autoimmune thyroid disease_Homo sapiens_hsa053200.48760586
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48649196
72Allograft rejection_Homo sapiens_hsa053300.48104292
73Calcium signaling pathway_Homo sapiens_hsa040200.47781266
74Carbon metabolism_Homo sapiens_hsa012000.47614506
75RNA transport_Homo sapiens_hsa030130.47562612
76Insulin secretion_Homo sapiens_hsa049110.45519679
77Circadian entrainment_Homo sapiens_hsa047130.45152032
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43718286
79Caffeine metabolism_Homo sapiens_hsa002320.43539234
80Regulation of autophagy_Homo sapiens_hsa041400.43294275
81Retinol metabolism_Homo sapiens_hsa008300.43208435
82Cocaine addiction_Homo sapiens_hsa050300.42800786
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.41297507
84Pyrimidine metabolism_Homo sapiens_hsa002400.41068180
85Vitamin B6 metabolism_Homo sapiens_hsa007500.41011593
86Dopaminergic synapse_Homo sapiens_hsa047280.40915345
87African trypanosomiasis_Homo sapiens_hsa051430.40425812
88Asthma_Homo sapiens_hsa053100.40401717
89Renin secretion_Homo sapiens_hsa049240.40238643
90Glutathione metabolism_Homo sapiens_hsa004800.39778312
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39365730
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39054231
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39042627
94Glutamatergic synapse_Homo sapiens_hsa047240.38480524
95Steroid biosynthesis_Homo sapiens_hsa001000.38119457
96Fat digestion and absorption_Homo sapiens_hsa049750.37407204
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37276203
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37188582
99Dilated cardiomyopathy_Homo sapiens_hsa054140.36815496
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33773914
101beta-Alanine metabolism_Homo sapiens_hsa004100.33166939
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32728127
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32389876
104Fatty acid degradation_Homo sapiens_hsa000710.31896063
105Folate biosynthesis_Homo sapiens_hsa007900.31746778
106Pancreatic secretion_Homo sapiens_hsa049720.31313167
107Selenocompound metabolism_Homo sapiens_hsa004500.31260206
108Sphingolipid metabolism_Homo sapiens_hsa006000.30852719
109Arginine and proline metabolism_Homo sapiens_hsa003300.29359107
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.29197983
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.29102974
112Chemical carcinogenesis_Homo sapiens_hsa052040.28844741
113Cholinergic synapse_Homo sapiens_hsa047250.28516392
114Fatty acid metabolism_Homo sapiens_hsa012120.28435660
115Long-term depression_Homo sapiens_hsa047300.26765933
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26367733
117Purine metabolism_Homo sapiens_hsa002300.26326583
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25845735
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25808210
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25774616
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25747038
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25639841
123Arginine biosynthesis_Homo sapiens_hsa002200.24272777
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.23277999
125Salivary secretion_Homo sapiens_hsa049700.21489958
126Long-term potentiation_Homo sapiens_hsa047200.19540981
127Olfactory transduction_Homo sapiens_hsa047400.19312479
128Gastric acid secretion_Homo sapiens_hsa049710.18695185
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18016862
130Other glycan degradation_Homo sapiens_hsa005110.17279897
131Tryptophan metabolism_Homo sapiens_hsa003800.16927047
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.15950517
133Prion diseases_Homo sapiens_hsa050200.14442065

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