NDUFA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.83062398
2tricarboxylic acid cycle (GO:0006099)7.14962877
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.11721461
4ATP synthesis coupled proton transport (GO:0015986)7.11721461
5* respiratory electron transport chain (GO:0022904)6.66164929
6* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.54603241
7* electron transport chain (GO:0022900)6.48387915
8oxidative phosphorylation (GO:0006119)6.07980432
9NADH metabolic process (GO:0006734)5.54556416
10regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.46947317
11regulation of acyl-CoA biosynthetic process (GO:0050812)5.24670920
12sarcomere organization (GO:0045214)5.16172503
13regulation of cofactor metabolic process (GO:0051193)4.96072471
14regulation of coenzyme metabolic process (GO:0051196)4.96072471
15lysine metabolic process (GO:0006553)4.81670250
16lysine catabolic process (GO:0006554)4.81670250
17succinate metabolic process (GO:0006105)4.74086127
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.62812758
19carnitine shuttle (GO:0006853)4.54198910
20cardiac myofibril assembly (GO:0055003)4.50586495
21ATP biosynthetic process (GO:0006754)4.43685022
22creatine metabolic process (GO:0006600)4.40629954
23fatty acid beta-oxidation (GO:0006635)4.30669293
24muscle filament sliding (GO:0030049)4.26603544
25actin-myosin filament sliding (GO:0033275)4.26603544
26aspartate family amino acid catabolic process (GO:0009068)4.25744338
27gluconeogenesis (GO:0006094)4.25173199
28ubiquinone biosynthetic process (GO:0006744)4.25006274
29quinone biosynthetic process (GO:1901663)4.25006274
302-oxoglutarate metabolic process (GO:0006103)4.24719293
31oxaloacetate metabolic process (GO:0006107)4.23952324
32negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.22611000
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.21679004
34fatty acid transmembrane transport (GO:1902001)4.18932504
35branched-chain amino acid catabolic process (GO:0009083)4.17435328
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.15792719
37cardiac muscle contraction (GO:0060048)4.15700527
38cellular ketone body metabolic process (GO:0046950)4.11256748
39inner mitochondrial membrane organization (GO:0007007)4.09002865
40myofibril assembly (GO:0030239)4.00765827
41aerobic respiration (GO:0009060)3.97315748
42regulation of sequestering of triglyceride (GO:0010889)3.90255509
43regulation of sulfur metabolic process (GO:0042762)3.85984627
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.85692404
45NADH dehydrogenase complex assembly (GO:0010257)3.85692404
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.85692404
47hexose biosynthetic process (GO:0019319)3.85453675
48regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.85033713
49protein complex biogenesis (GO:0070271)3.83797801
50dicarboxylic acid biosynthetic process (GO:0043650)3.82457124
51fatty acid catabolic process (GO:0009062)3.81414968
52ubiquinone metabolic process (GO:0006743)3.77120462
53heart process (GO:0003015)3.75260600
54heart contraction (GO:0060047)3.75260600
55acetyl-CoA metabolic process (GO:0006084)3.73883275
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.71972034
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.71410770
58negative regulation of potassium ion transmembrane transport (GO:1901380)3.70883293
59regulation of relaxation of muscle (GO:1901077)3.70354641
60mitochondrial respiratory chain complex assembly (GO:0033108)3.69722018
61tricarboxylic acid metabolic process (GO:0072350)3.69620367
62short-chain fatty acid metabolic process (GO:0046459)3.69446678
63branched-chain amino acid metabolic process (GO:0009081)3.68842351
64fatty acid oxidation (GO:0019395)3.66345150
65regulation of mitochondrial translation (GO:0070129)3.62176754
66monosaccharide biosynthetic process (GO:0046364)3.60669349
67ketone body metabolic process (GO:1902224)3.58617090
68lipid oxidation (GO:0034440)3.58357118
69cardiac muscle cell development (GO:0055013)3.52942726
70regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.51309127
71nucleoside diphosphate biosynthetic process (GO:0009133)3.50123950
72aldehyde catabolic process (GO:0046185)3.48802006
73regulation of cell communication by electrical coupling (GO:0010649)3.47638814
74carnitine transmembrane transport (GO:1902603)3.46891040
75hydrogen ion transmembrane transport (GO:1902600)3.43691387
76carnitine transport (GO:0015879)3.41921847
77amino-acid betaine transport (GO:0015838)3.41921847
78regulation of actin filament-based movement (GO:1903115)3.41422296
79actin-mediated cell contraction (GO:0070252)3.39589051
80regulation of fatty acid oxidation (GO:0046320)3.39164112
81dicarboxylic acid catabolic process (GO:0043649)3.38903150
82negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.37692999
83ventricular cardiac muscle cell action potential (GO:0086005)3.37058571
84glyoxylate metabolic process (GO:0046487)3.36079216
85cellular respiration (GO:0045333)3.34758922
86ribonucleoside triphosphate biosynthetic process (GO:0009201)3.34686729
87regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.33661805
88monocarboxylic acid catabolic process (GO:0072329)3.33360083
89regulation of skeletal muscle contraction (GO:0014819)3.32800443
90cardiac muscle tissue morphogenesis (GO:0055008)3.32251695
91purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.30663348
92purine nucleoside monophosphate biosynthetic process (GO:0009127)3.30663348
93bundle of His cell to Purkinje myocyte communication (GO:0086069)3.29055808
94L-phenylalanine metabolic process (GO:0006558)3.25173233
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.25173233
96carnitine metabolic process (GO:0009437)3.22821211
97cardiac cell development (GO:0055006)3.21091524
98regulation of oxidative phosphorylation (GO:0002082)3.20859922
99mitochondrial transport (GO:0006839)3.17641351
100striated muscle contraction (GO:0006941)3.17307826
101ADP metabolic process (GO:0046031)3.16915868
102ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.13525380
103erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.11863056
104L-phenylalanine catabolic process (GO:0006559)3.11863056
105COPI coating of Golgi vesicle (GO:0048205)3.10428792
106Golgi transport vesicle coating (GO:0048200)3.10428792
107glycolytic process (GO:0006096)3.09956160
108proline biosynthetic process (GO:0006561)3.07069491
109skeletal muscle contraction (GO:0003009)3.05388720
110heart trabecula formation (GO:0060347)3.04892974
111valine metabolic process (GO:0006573)3.04863691
112regulation of cellular respiration (GO:0043457)3.04453078
113* generation of precursor metabolites and energy (GO:0006091)3.01408226
114plasma membrane repair (GO:0001778)3.00189319
115fructose metabolic process (GO:0006000)2.99667652
116cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98697799
117sarcoplasmic reticulum calcium ion transport (GO:0070296)2.98486560
118muscle tissue morphogenesis (GO:0060415)2.97957655
119biotin metabolic process (GO:0006768)2.95525489
120nucleoside triphosphate biosynthetic process (GO:0009142)2.94872953
121glycogen catabolic process (GO:0005980)2.89958493
122negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.89140607
123negative regulation of calcium ion transmembrane transport (GO:1903170)2.89140607
124retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87805806
125AMP metabolic process (GO:0046033)2.86682828
126fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.86149893
127response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.78212924
128cell communication involved in cardiac conduction (GO:0086065)2.77327835
129cullin deneddylation (GO:0010388)2.77054040
130pyruvate metabolic process (GO:0006090)2.75843032
131regulation of cardiac muscle cell contraction (GO:0086004)2.75186720
132muscle cell cellular homeostasis (GO:0046716)2.69567575
133glutamate metabolic process (GO:0006536)2.68393229
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68134084
135proline metabolic process (GO:0006560)2.62736309
136glucan catabolic process (GO:0009251)2.58924610
137positive regulation of mitochondrial fission (GO:0090141)2.57218185
138cardiac muscle hypertrophy (GO:0003300)2.55904358
139striated muscle hypertrophy (GO:0014897)2.55189616
140positive regulation of cellular amine metabolic process (GO:0033240)2.54795473
141regulation of cholesterol esterification (GO:0010872)2.53743113
142glucan biosynthetic process (GO:0009250)2.53549198
143glycogen biosynthetic process (GO:0005978)2.53549198
144cell communication by electrical coupling (GO:0010644)2.51755390
145detection of calcium ion (GO:0005513)2.51706810
146positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.50723710
147glutamine family amino acid biosynthetic process (GO:0009084)2.49731064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.14900067
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.27039125
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.96397857
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.04536154
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.99137173
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47774356
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.01346745
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95690487
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92068802
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.91159496
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84015168
12ZNF263_19887448_ChIP-Seq_K562_Human2.72040935
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.65973508
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.65784090
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.45105965
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.35249236
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.30771226
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24893580
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18871070
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17258284
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17246217
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12921808
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.11377595
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10700615
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01222552
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.00111437
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93538077
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91083086
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.87478877
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82593374
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81063990
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79925109
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.76091891
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70455396
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63683499
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63365622
37BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.61449896
38MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.58445263
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58408059
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57970068
41* DCP1A_22483619_ChIP-Seq_HELA_Human1.57328434
42GATA4_21415370_ChIP-Seq_HL-1_Mouse1.56056979
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55871407
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54862050
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54583949
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.53293716
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52105859
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.47503002
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46661119
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44127036
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43045234
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42278934
53SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.40727440
54XRN2_22483619_ChIP-Seq_HELA_Human1.38970549
55* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38293072
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37303852
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36316166
58TBX20_22328084_ChIP-Seq_HEART_Mouse1.34652430
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.34652430
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33528059
61* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30156715
62CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.27016925
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26765181
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26560720
65GABP_19822575_ChIP-Seq_HepG2_Human1.26415177
66CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23408899
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22484920
68RARB_27405468_Chip-Seq_BRAIN_Mouse1.21154516
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18623385
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17600264
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16596877
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16460325
73TBX5_21415370_ChIP-Seq_HL-1_Mouse1.13775087
74FOXP3_21729870_ChIP-Seq_TREG_Human1.13770581
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13342558
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12011157
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10361046
78VDR_23849224_ChIP-Seq_CD4+_Human1.10332128
79CLOCK_20551151_ChIP-Seq_293T_Human1.07926675
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.06221878
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04243156
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01654404
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00085323
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99346375
85KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99341917
86* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99276323
87TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98934904
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98525529
89TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98368736
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97500917
91TFEB_21752829_ChIP-Seq_HELA_Human0.96833002
92TTF2_22483619_ChIP-Seq_HELA_Human0.96078532
93OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93043621
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92817456
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91402674
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.90889157
97BCL6_27268052_Chip-Seq_Bcells_Human0.90239506
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89966209
99NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88128957
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87635797
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86766875
102ELF1_20517297_ChIP-Seq_JURKAT_Human0.85185373
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84900928
104KDM5A_27292631_Chip-Seq_BREAST_Human0.84119750
105SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.83098024
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83088654
107REST_18959480_ChIP-ChIP_MESCs_Mouse0.82105040
108MYC_18940864_ChIP-ChIP_HL60_Human0.82094467
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81211534
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80526075
111FOXP1_21924763_ChIP-Seq_HESCs_Human0.79713987
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.79568139
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79159537
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77284459
115* TAF2_19829295_ChIP-Seq_ESCs_Human0.76379091
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76341724
117BCOR_27268052_Chip-Seq_Bcells_Human0.74728670
118* P68_20966046_ChIP-Seq_HELA_Human0.74611086
119ERA_21632823_ChIP-Seq_H3396_Human0.74497079
120CIITA_25753668_ChIP-Seq_RAJI_Human0.74172160
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73984628
122* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73386122
123RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.73250115
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72630676
125SPI1_20517297_ChIP-Seq_HL60_Human0.72542915
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71884529
127* ATF3_27146783_Chip-Seq_COLON_Human0.70882136
128TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69584739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.06555523
2MP0003646_muscle_fatigue5.22568067
3MP0004084_abnormal_cardiac_muscle4.20232493
4MP0000751_myopathy4.14149542
5MP0004215_abnormal_myocardial_fiber4.00602519
6MP0005330_cardiomyopathy3.46669692
7MP0000749_muscle_degeneration3.42184435
8MP0004036_abnormal_muscle_relaxation3.40416713
9MP0006036_abnormal_mitochondrial_physio3.29354922
10MP0003806_abnormal_nucleotide_metabolis2.91388082
11MP0005360_urolithiasis2.73200814
12MP0004270_analgesia2.60167647
13MP0004859_abnormal_synaptic_plasticity2.58501141
14MP0002139_abnormal_hepatobiliary_system2.51085353
15MP0002972_abnormal_cardiac_muscle2.48862623
16MP0008775_abnormal_heart_ventricle2.43953361
17MP0004087_abnormal_muscle_fiber2.40064857
18MP0003137_abnormal_impulse_conducting2.34807719
19MP0004130_abnormal_muscle_cell2.31650642
20MP0003880_abnormal_central_pattern2.31021282
21MP0005085_abnormal_gallbladder_physiolo2.29436117
22MP0005620_abnormal_muscle_contractility2.25567600
23MP0006035_abnormal_mitochondrial_morpho2.14187647
24MP0005385_cardiovascular_system_phenoty2.12430363
25MP0001544_abnormal_cardiovascular_syste2.12430363
26MP0002269_muscular_atrophy2.09854927
27MP0003221_abnormal_cardiomyocyte_apopto2.07114658
28MP0000750_abnormal_muscle_regeneration2.03800616
29MP0004484_altered_response_of1.97252122
30MP0004145_abnormal_muscle_electrophysio1.94152131
31MP0002106_abnormal_muscle_physiology1.93938243
32MP0000747_muscle_weakness1.91935294
33MP0006138_congestive_heart_failure1.90285847
34MP0001984_abnormal_olfaction1.89384441
35MP0005332_abnormal_amino_acid1.87568435
36MP0005058_abnormal_lysosome_morphology1.82750631
37MP0010630_abnormal_cardiac_muscle1.77250991
38MP0005670_abnormal_white_adipose1.72092475
39MP0001661_extended_life_span1.70348467
40MP0005365_abnormal_bile_salt1.70253487
41MP0008260_abnormal_autophagy1.66760535
42MP0004085_abnormal_heartbeat1.66484698
43MP0005666_abnormal_adipose_tissue1.64776665
44MP0008875_abnormal_xenobiotic_pharmacok1.63601902
45MP0000759_abnormal_skeletal_muscle1.60905344
46MP0000003_abnormal_adipose_tissue1.58990194
47MP0005423_abnormal_somatic_nervous1.54238253
48MP0005369_muscle_phenotype1.53039611
49MP0002064_seizures1.43881121
50MP0009046_muscle_twitch1.41684519
51MP0004043_abnormal_pH_regulation1.39559243
52MP0002332_abnormal_exercise_endurance1.39195376
53MP0003195_calcinosis1.37939514
54MP0004147_increased_porphyrin_level1.37772692
55MP0009840_abnormal_foam_cell1.37444659
56MP0004233_abnormal_muscle_weight1.33807321
57MP0003186_abnormal_redox_activity1.33116709
58MP0002822_catalepsy1.29424552
59MP0005266_abnormal_metabolism1.28678858
60MP0002127_abnormal_cardiovascular_syste1.27582894
61MP0005083_abnormal_biliary_tract1.27462810
62MP0003828_pulmonary_edema1.24190554
63MP0003635_abnormal_synaptic_transmissio1.21823627
64MP0008569_lethality_at_weaning1.21597492
65MP0005584_abnormal_enzyme/coenzyme_acti1.21367314
66MP0009780_abnormal_chondrocyte_physiolo1.21343725
67MP0009379_abnormal_foot_pigmentation1.20775181
68MP0005319_abnormal_enzyme/_coenzyme1.20458678
69MP0002090_abnormal_vision1.18474926
70MP0010329_abnormal_lipoprotein_level1.17257293
71MP0005451_abnormal_body_composition1.16883494
72MP0005535_abnormal_body_temperature1.12608290
73MP0002272_abnormal_nervous_system1.09240449
74MP0002971_abnormal_brown_adipose1.07946717
75MP0004185_abnormal_adipocyte_glucose1.04942593
76MP0003879_abnormal_hair_cell1.03504297
77MP0002734_abnormal_mechanical_nocicepti1.02241860
78MP0001529_abnormal_vocalization1.02048323
79MP0002118_abnormal_lipid_homeostasis1.01693557
80MP0001764_abnormal_homeostasis1.00540941
81MP0000230_abnormal_systemic_arterial0.99021979
82MP0008058_abnormal_DNA_repair0.96850582
83MP0003656_abnormal_erythrocyte_physiolo0.95747035
84MP0003567_abnormal_fetal_cardiomyocyte0.94716815
85MP0009745_abnormal_behavioral_response0.94183478
86MP0005165_increased_susceptibility_to0.94071989
87MP0005646_abnormal_pituitary_gland0.90656559
88MP0005375_adipose_tissue_phenotype0.90315666
89MP0009643_abnormal_urine_homeostasis0.86902291
90MP0005636_abnormal_mineral_homeostasis0.80838039
91MP0002063_abnormal_learning/memory/cond0.80629940
92MP0003868_abnormal_feces_composition0.80049608
93MP0002066_abnormal_motor_capabilities/c0.79077296
94MP0001346_abnormal_lacrimal_gland0.78058448
95MP0002078_abnormal_glucose_homeostasis0.77870115
96MP0003111_abnormal_nucleus_morphology0.76130165
97MP0003786_premature_aging0.75952902
98MP0003690_abnormal_glial_cell0.75889435
99MP0000343_altered_response_to0.75101712
100MP0008007_abnormal_cellular_replicative0.72599892
101MP0000920_abnormal_myelination0.72372834
102MP0005187_abnormal_penis_morphology0.71664313
103MP0008995_early_reproductive_senescence0.71589559
104MP0005376_homeostasis/metabolism_phenot0.71291175
105MP0001666_abnormal_nutrient_absorption0.71077001
106MP0000604_amyloidosis0.70217387
107MP0001486_abnormal_startle_reflex0.70170146
108MP0003950_abnormal_plasma_membrane0.70164371
109MP0004510_myositis0.70094954
110MP0001501_abnormal_sleep_pattern0.70076095
111MP0002876_abnormal_thyroid_physiology0.69947295
112MP0002229_neurodegeneration0.69810272
113MP0006276_abnormal_autonomic_nervous0.69460560
114MP0003191_abnormal_cellular_cholesterol0.68953624
115MP0000013_abnormal_adipose_tissue0.68103428
116MP0000266_abnormal_heart_morphology0.66800446
117MP0000609_abnormal_liver_physiology0.66554766
118MP0003329_amyloid_beta_deposits0.64613625
119MP0002736_abnormal_nociception_after0.64363298
120MP0005386_behavior/neurological_phenoty0.62899070
121MP0004924_abnormal_behavior0.62899070
122MP0003252_abnormal_bile_duct0.62270992
123MP0000358_abnormal_cell_content/0.60410883
124MP0004142_abnormal_muscle_tone0.58756617
125MP0001756_abnormal_urination0.54238788
126MP0003011_delayed_dark_adaptation0.53415746
127MP0005334_abnormal_fat_pad0.51953850
128MP0002970_abnormal_white_adipose0.51887010
129MP0002735_abnormal_chemical_nociception0.50796071
130MP0001765_abnormal_ion_homeostasis0.48816569
131MP0005452_abnormal_adipose_tissue0.47985702
132MP0009697_abnormal_copulation0.47599749
133MP0008872_abnormal_physiological_respon0.47447184
134MP0005448_abnormal_energy_balance0.45854473
135MP0002909_abnormal_adrenal_gland0.45267692
136MP0001968_abnormal_touch/_nociception0.43202701
137MP0004019_abnormal_vitamin_homeostasis0.42188852

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.25293353
2Acute necrotizing encephalopathy (HP:0006965)5.24976135
3Sudden death (HP:0001699)5.21703908
4* Hepatic necrosis (HP:0002605)5.03213297
5Acute encephalopathy (HP:0006846)4.88693642
6Nemaline bodies (HP:0003798)4.88267519
7Muscle fiber inclusion bodies (HP:0100299)4.85889869
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.75242047
9* Hepatocellular necrosis (HP:0001404)4.70133780
10* Mitochondrial inheritance (HP:0001427)4.65058007
11Myoglobinuria (HP:0002913)4.57674983
12* Increased CSF lactate (HP:0002490)4.41002075
13Progressive macrocephaly (HP:0004481)4.37908888
14Increased muscle lipid content (HP:0009058)4.33499830
15Cerebral edema (HP:0002181)4.31505586
16Exercise-induced myalgia (HP:0003738)4.16754302
17Calf muscle hypertrophy (HP:0008981)4.13672626
18Ventricular tachycardia (HP:0004756)4.05417799
19Increased intramyocellular lipid droplets (HP:0012240)4.04050766
20Rhabdomyolysis (HP:0003201)3.98962082
21Abnormality of glycolysis (HP:0004366)3.93463935
22Increased serum pyruvate (HP:0003542)3.93463935
23Muscle hypertrophy of the lower extremities (HP:0008968)3.89073882
24Exercise-induced muscle cramps (HP:0003710)3.87125983
25* Lactic acidosis (HP:0003128)3.82943728
26Palpitations (HP:0001962)3.77409166
27Lipid accumulation in hepatocytes (HP:0006561)3.70083258
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.68167877
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.68167877
30Dicarboxylic aciduria (HP:0003215)3.62868381
31Abnormality of dicarboxylic acid metabolism (HP:0010995)3.62868381
32Abnormality of fatty-acid metabolism (HP:0004359)3.61646564
33Centrally nucleated skeletal muscle fibers (HP:0003687)3.41590663
34Lipoatrophy (HP:0100578)3.40768045
35Exercise intolerance (HP:0003546)3.39607687
36Atrial fibrillation (HP:0005110)3.38639799
37* Respiratory failure (HP:0002878)3.36927414
38Increased hepatocellular lipid droplets (HP:0006565)3.33452407
39Rimmed vacuoles (HP:0003805)3.32910507
40Ketoacidosis (HP:0001993)3.30260116
41Abnormality of the calf musculature (HP:0001430)3.22098141
42Hypoglycemic coma (HP:0001325)3.21643446
43Hyperglycinuria (HP:0003108)3.19738351
44Hyperammonemia (HP:0001987)3.18499985
45* Increased serum lactate (HP:0002151)3.17956755
46Supraventricular tachycardia (HP:0004755)3.17891784
47Primary atrial arrhythmia (HP:0001692)3.17612761
48Myopathic facies (HP:0002058)3.14816497
49Ragged-red muscle fibers (HP:0003200)3.14293717
50Abnormality of alanine metabolism (HP:0010916)3.14275272
51Hyperalaninemia (HP:0003348)3.14275272
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14275272
53Muscle fiber splitting (HP:0003555)3.12099480
54Supraventricular arrhythmia (HP:0005115)3.09551742
55Type 1 muscle fiber predominance (HP:0003803)3.06148946
56Ketosis (HP:0001946)3.05267005
57Dilated cardiomyopathy (HP:0001644)3.03893877
58Lethargy (HP:0001254)3.02146285
59Abnormal gallbladder physiology (HP:0012438)3.01483569
60Cholecystitis (HP:0001082)3.01483569
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.97560416
62Syncope (HP:0001279)2.94280523
63Conjunctival hamartoma (HP:0100780)2.85757201
64Abnormality of glycine metabolism (HP:0010895)2.84571501
65Abnormality of serine family amino acid metabolism (HP:0010894)2.84571501
66Microvesicular hepatic steatosis (HP:0001414)2.84450246
67Pheochromocytoma (HP:0002666)2.81991476
68Right ventricular cardiomyopathy (HP:0011663)2.79048666
69Generalized aminoaciduria (HP:0002909)2.77826271
70Neck muscle weakness (HP:0000467)2.77580342
71Myokymia (HP:0002411)2.74625520
72Neuroendocrine neoplasm (HP:0100634)2.67293277
73Distal arthrogryposis (HP:0005684)2.63293999
74EMG: myopathic abnormalities (HP:0003458)2.61373511
75Prolonged QT interval (HP:0001657)2.59971161
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.59576689
77Optic disc pallor (HP:0000543)2.58633830
78Muscle stiffness (HP:0003552)2.57757715
79Distal lower limb muscle weakness (HP:0009053)2.56471075
80Hyporeflexia of lower limbs (HP:0002600)2.54485505
81Ventricular fibrillation (HP:0001663)2.51061609
82Subaortic stenosis (HP:0001682)2.50766185
83Abnormality of the left ventricular outflow tract (HP:0011103)2.50766185
84Glycosuria (HP:0003076)2.50325978
85Abnormality of urine glucose concentration (HP:0011016)2.50325978
86Ventricular arrhythmia (HP:0004308)2.46414230
87Cerebral hypomyelination (HP:0006808)2.44824864
88Metabolic acidosis (HP:0001942)2.44573945
89Myotonia (HP:0002486)2.43703765
90* CNS demyelination (HP:0007305)2.43188924
91Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41817210
92Leukodystrophy (HP:0002415)2.41094944
93Renal Fanconi syndrome (HP:0001994)2.40871077
94Bundle branch block (HP:0011710)2.40870668
95Proximal tubulopathy (HP:0000114)2.39534506
96Vomiting (HP:0002013)2.39379795
97Hyperglycinemia (HP:0002154)2.38341850
98Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37442098
99Nausea (HP:0002018)2.36750006
100Asymmetric septal hypertrophy (HP:0001670)2.34253869
101Abnormality of skeletal muscle fiber size (HP:0012084)2.26917330
102Methylmalonic aciduria (HP:0012120)2.24576531
103Respiratory difficulties (HP:0002880)2.22500157
104Neoplasm of head and neck (HP:0012288)2.21414887
105Esophageal neoplasm (HP:0100751)2.21414887
106Cholelithiasis (HP:0001081)2.19576609
107Increased connective tissue (HP:0009025)2.19316094
108Abnormality of serum amino acid levels (HP:0003112)2.17447559
109EMG: neuropathic changes (HP:0003445)2.17388396
110Progressive external ophthalmoplegia (HP:0000590)2.15314689
111Neoplasm of the adrenal gland (HP:0100631)2.14628976
112Heart block (HP:0012722)2.14568827
113Gout (HP:0001997)2.07190332
114Abnormal gallbladder morphology (HP:0012437)2.06019689
115Cerebral palsy (HP:0100021)2.05985184
116* Emotional lability (HP:0000712)2.05515355
117Multiple enchondromatosis (HP:0005701)2.05191907
118Atrioventricular block (HP:0001678)2.03772309
119Abnormal atrioventricular conduction (HP:0005150)2.01060433
120Athetosis (HP:0002305)2.00860710
121Abnormal EKG (HP:0003115)2.00168151
122Difficulty running (HP:0009046)1.98404551
123Testicular atrophy (HP:0000029)1.98024893
124Progressive muscle weakness (HP:0003323)1.93161127
125Abnormality of the foot musculature (HP:0001436)1.91325751
126Fetal akinesia sequence (HP:0001989)1.90813225
127Increased variability in muscle fiber diameter (HP:0003557)1.86906439
128Limb-girdle muscle atrophy (HP:0003797)1.86601404
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86536345
130Malignant hyperthermia (HP:0002047)1.84936939
131Resting tremor (HP:0002322)1.83531857
132Type I transferrin isoform profile (HP:0003642)1.77861066
133Tetraplegia (HP:0002445)1.77339822
134Ankle clonus (HP:0011448)1.74096310
135Deep venous thrombosis (HP:0002625)1.72473658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.22946930
2OBSCN4.01311697
3LMTK24.01194891
4PDK33.76447699
5PDK43.76447699
6MYLK3.68934771
7TTN3.33354786
8NEK13.28129713
9PHKG23.16376700
10PHKG13.16376700
11NME22.47611977
12NME12.47102704
13PKN22.45981495
14PBK1.97582869
15PINK11.94536946
16PDK21.90214203
17TESK11.88915610
18WNK41.84527692
19TRIB31.79644211
20MAP3K121.69244896
21VRK21.65328422
22EIF2AK11.62357516
23TLK11.60652043
24TIE11.49888229
25PAK61.48897506
26ILK1.48557557
27MUSK1.43173440
28PRKD31.42913853
29UHMK11.42753204
30PIK3CA1.40471072
31GRK71.40455129
32STK161.30839881
33MAP3K111.29156400
34STK241.29150628
35CCNB11.28797094
36EIF2AK31.26401132
37KDR1.26138088
38CSNK1G31.26079860
39MAP2K41.23707919
40MARK11.21024506
41DAPK31.20477021
42DMPK1.17145537
43CAMK2D1.15144714
44FGFR41.08417987
45PRPF4B1.07789240
46STK38L1.02837963
47CDK190.97783876
48STK390.96416909
49CSNK1A1L0.92462014
50CSNK1G20.90744340
51ABL20.90453595
52MAP2K30.83703301
53CSNK1G10.83651126
54FLT30.83320494
55MINK10.80867710
56CAMK2G0.80559669
57MAPKAPK30.77091906
58MAP3K50.77044802
59MAPK120.73309394
60RPS6KB20.72605047
61CDK180.72503561
62MAP2K60.72460622
63EPHA30.71994960
64NEK90.70406082
65CDK11A0.70003818
66CDK150.69142152
67PAK30.68989185
68ERBB30.68533585
69BUB10.67881577
70CAMK2A0.67105691
71MAP3K40.66218307
72CDK140.64852880
73RIPK10.62121961
74LIMK10.61358194
75DYRK1B0.59845309
76ROCK10.59553138
77DYRK1A0.57590774
78PRKD10.56655344
79ZAK0.55236706
80DAPK20.54696424
81ROCK20.53723202
82FGFR30.53680052
83WEE10.52926332
84CDK50.52816768
85ARAF0.52669286
86CAMKK10.52350778
87ALK0.51703415
88CAMK10.51317913
89BRAF0.51000517
90MAPKAPK50.50734589
91PRKACA0.50067446
92OXSR10.48843110
93MAP3K70.48709980
94PRKAA10.48418631
95RPS6KB10.47028807
96SRPK10.46886604
97CSNK1E0.43096521
98PIM20.42983866
99PRKAA20.42630926
100PRKACG0.42567876
101CAMK40.42502155
102PRKACB0.42352514
103PRKG20.41814979
104MST1R0.40513942
105SIK30.38126627
106ADRBK10.37477485
107RPS6KA30.37140840
108TRIM280.36296624
109MAPK100.35937453
110CAMK2B0.35647231
111PDK10.35572867
112AKT20.35345766
113NEK60.35291019
114CSNK1A10.34941935
115STK40.34673649
116MAP2K10.34269008
117PTK2B0.33667172
118GRK50.32149242
119PDPK10.31832243
120CDK90.31425922
121EPHA40.30874239
122PIK3CG0.30757299
123EIF2AK20.30425682
124FER0.29437281
125RPS6KL10.28920391
126RPS6KC10.28920391
127CASK0.28518994
128MAPK110.28425547
129AURKA0.28419927
130SMG10.28216363
131VRK10.28196487
132MAP2K70.27972156
133MAPK40.27890322
134SCYL20.24656008
135CSNK2A20.23959095
136PRKCG0.22968909
137TTK0.22412394
138CSNK2A10.21574382
139LRRK20.20611504
140NTRK30.20504516
141PRKCE0.20167441
142RPS6KA60.19890620
143DAPK10.19874133
144STK380.18991023
145TESK20.18327789
146PRKCA0.16108989

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.14132500
2* Oxidative phosphorylation_Homo sapiens_hsa001904.12021083
3Parkinsons disease_Homo sapiens_hsa050123.84310778
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.77200608
5Propanoate metabolism_Homo sapiens_hsa006403.46577849
6Cardiac muscle contraction_Homo sapiens_hsa042602.93663208
7Fatty acid degradation_Homo sapiens_hsa000712.91196757
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.86731580
9Alzheimers disease_Homo sapiens_hsa050102.74809541
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73057863
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68795663
12Carbon metabolism_Homo sapiens_hsa012002.63240067
13Huntingtons disease_Homo sapiens_hsa050162.52249978
14Pyruvate metabolism_Homo sapiens_hsa006202.48251197
15* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.45647305
16Fatty acid metabolism_Homo sapiens_hsa012122.23061229
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12637026
18Butanoate metabolism_Homo sapiens_hsa006502.08677638
19Fatty acid elongation_Homo sapiens_hsa000621.78639762
20Biosynthesis of amino acids_Homo sapiens_hsa012301.60140340
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59957778
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52211052
23Ribosome_Homo sapiens_hsa030101.52147360
24Proteasome_Homo sapiens_hsa030501.49074881
25Peroxisome_Homo sapiens_hsa041461.43110112
26Tryptophan metabolism_Homo sapiens_hsa003801.38038381
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35867870
28PPAR signaling pathway_Homo sapiens_hsa033201.33652875
29Arginine biosynthesis_Homo sapiens_hsa002201.32143081
30Synaptic vesicle cycle_Homo sapiens_hsa047211.29681414
31beta-Alanine metabolism_Homo sapiens_hsa004101.27432259
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.20720796
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10199072
34Dilated cardiomyopathy_Homo sapiens_hsa054141.09588613
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.08334676
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06445739
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99477879
38Phenylalanine metabolism_Homo sapiens_hsa003600.91574876
39Vibrio cholerae infection_Homo sapiens_hsa051100.89588577
40Starch and sucrose metabolism_Homo sapiens_hsa005000.88427155
41Arginine and proline metabolism_Homo sapiens_hsa003300.86292635
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84795912
43Sulfur metabolism_Homo sapiens_hsa009200.82344527
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79274034
45* Metabolic pathways_Homo sapiens_hsa011000.78476324
46Sulfur relay system_Homo sapiens_hsa041220.78069773
47Fructose and mannose metabolism_Homo sapiens_hsa000510.77233694
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.76690865
49Tyrosine metabolism_Homo sapiens_hsa003500.75388719
50Pentose phosphate pathway_Homo sapiens_hsa000300.73472279
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71739578
52Galactose metabolism_Homo sapiens_hsa000520.67713904
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67541806
54Folate biosynthesis_Homo sapiens_hsa007900.66984702
55Glutathione metabolism_Homo sapiens_hsa004800.66346784
56Base excision repair_Homo sapiens_hsa034100.63363586
57Nitrogen metabolism_Homo sapiens_hsa009100.60498553
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58655017
59Fat digestion and absorption_Homo sapiens_hsa049750.57596312
60Other glycan degradation_Homo sapiens_hsa005110.56535237
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.55915188
62Amphetamine addiction_Homo sapiens_hsa050310.53463387
63GABAergic synapse_Homo sapiens_hsa047270.52196756
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51826538
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51798796
66Glucagon signaling pathway_Homo sapiens_hsa049220.50587671
67Chemical carcinogenesis_Homo sapiens_hsa052040.49430030
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48154580
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48029133
70Non-homologous end-joining_Homo sapiens_hsa034500.47286143
71RNA polymerase_Homo sapiens_hsa030200.46670747
72Glycerolipid metabolism_Homo sapiens_hsa005610.45680652
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44895220
74Circadian rhythm_Homo sapiens_hsa047100.44867145
75Fatty acid biosynthesis_Homo sapiens_hsa000610.43789133
76Pyrimidine metabolism_Homo sapiens_hsa002400.43384752
77Oocyte meiosis_Homo sapiens_hsa041140.43163500
78Bile secretion_Homo sapiens_hsa049760.41547769
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38453252
80Histidine metabolism_Homo sapiens_hsa003400.35649442
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33507540
82Selenocompound metabolism_Homo sapiens_hsa004500.33137191
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32010975
84Insulin secretion_Homo sapiens_hsa049110.31885633
85One carbon pool by folate_Homo sapiens_hsa006700.31696631
86Steroid biosynthesis_Homo sapiens_hsa001000.31675985
87Caffeine metabolism_Homo sapiens_hsa002320.31416947
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.30271651
89Insulin signaling pathway_Homo sapiens_hsa049100.29402720
90Long-term potentiation_Homo sapiens_hsa047200.27669342
91Dopaminergic synapse_Homo sapiens_hsa047280.26374449
92Purine metabolism_Homo sapiens_hsa002300.26271816
93Collecting duct acid secretion_Homo sapiens_hsa049660.26037756
94Nicotine addiction_Homo sapiens_hsa050330.25072006
95DNA replication_Homo sapiens_hsa030300.23994858
96Spliceosome_Homo sapiens_hsa030400.22751478
97Renin secretion_Homo sapiens_hsa049240.22421699
98Retinol metabolism_Homo sapiens_hsa008300.22007383
99Insulin resistance_Homo sapiens_hsa049310.21255588
100AMPK signaling pathway_Homo sapiens_hsa041520.21089402
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20972855
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.18686055
103Lysine degradation_Homo sapiens_hsa003100.16816874
104Calcium signaling pathway_Homo sapiens_hsa040200.13862697
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13664945
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.11076264
107Protein export_Homo sapiens_hsa030600.10426278
108HIF-1 signaling pathway_Homo sapiens_hsa040660.09043101
109Viral myocarditis_Homo sapiens_hsa054160.08243916
110Mismatch repair_Homo sapiens_hsa034300.08154468
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.06509572
112Complement and coagulation cascades_Homo sapiens_hsa046100.05654960
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.05259675
114Vitamin B6 metabolism_Homo sapiens_hsa007500.01015712
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0071648
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0014547

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