NDUFA11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.87429162
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.87429162
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.32668109
4* respiratory electron transport chain (GO:0022904)8.30837701
5* electron transport chain (GO:0022900)8.09686132
6protein complex biogenesis (GO:0070271)5.67587412
7chaperone-mediated protein transport (GO:0072321)5.53342891
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.52163469
9maturation of SSU-rRNA (GO:0030490)5.46910938
10ATP biosynthetic process (GO:0006754)5.43986422
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.34632566
12NADH dehydrogenase complex assembly (GO:0010257)5.34632566
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.34632566
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.30759918
15protein neddylation (GO:0045116)5.23254500
16hydrogen ion transmembrane transport (GO:1902600)5.14383056
17mitochondrial respiratory chain complex assembly (GO:0033108)5.14042879
18purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.09051744
19translational initiation (GO:0006413)5.03551101
20purine nucleoside triphosphate biosynthetic process (GO:0009145)4.99133708
21oxidative phosphorylation (GO:0006119)4.88787069
22inner mitochondrial membrane organization (GO:0007007)4.78774050
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.74340213
24protein complex disassembly (GO:0043241)4.70442465
25proton transport (GO:0015992)4.47663237
26ribosomal large subunit biogenesis (GO:0042273)4.44091236
27macromolecular complex disassembly (GO:0032984)4.43878481
28ribonucleoside triphosphate biosynthetic process (GO:0009201)4.42476192
29hydrogen transport (GO:0006818)4.38771781
30protein targeting to membrane (GO:0006612)4.34292998
31regulation of mitochondrial translation (GO:0070129)4.29738418
32regulation of oxidative phosphorylation (GO:0002082)3.90391994
33cellular component biogenesis (GO:0044085)3.90180260
34ribosomal small subunit biogenesis (GO:0042274)3.87488542
35GTP biosynthetic process (GO:0006183)3.86780368
36respiratory chain complex IV assembly (GO:0008535)3.83025478
37nucleoside triphosphate biosynthetic process (GO:0009142)3.81579650
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.80634564
39ATP hydrolysis coupled proton transport (GO:0015991)3.76116872
40energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.76116872
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.75666946
42cytochrome complex assembly (GO:0017004)3.72089349
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69933035
44sequestering of actin monomers (GO:0042989)3.63387586
45mRNA catabolic process (GO:0006402)3.55703006
46ribonucleoprotein complex biogenesis (GO:0022613)3.53167156
47viral transcription (GO:0019083)3.52920734
48establishment of protein localization to mitochondrion (GO:0072655)3.48129578
49pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.47081519
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46372301
51negative regulation of ligase activity (GO:0051352)3.46372301
52tricarboxylic acid cycle (GO:0006099)3.45662456
53cullin deneddylation (GO:0010388)3.45543159
54peptidyl-histidine modification (GO:0018202)3.45448237
55protein targeting to mitochondrion (GO:0006626)3.45297138
56proteasome assembly (GO:0043248)3.41455449
57CTP biosynthetic process (GO:0006241)3.40518505
58pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.40467290
59aerobic respiration (GO:0009060)3.38957102
60mitochondrial transport (GO:0006839)3.38554452
61translational termination (GO:0006415)3.38489375
62dopamine transport (GO:0015872)3.38027251
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31932596
64protein-cofactor linkage (GO:0018065)3.31459562
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29656466
66cotranslational protein targeting to membrane (GO:0006613)3.28488976
67protein localization to mitochondrion (GO:0070585)3.27731199
68pseudouridine synthesis (GO:0001522)3.25477089
69base-excision repair, AP site formation (GO:0006285)3.24104485
70RNA catabolic process (GO:0006401)3.23263991
71rRNA modification (GO:0000154)3.23208423
72protein targeting to ER (GO:0045047)3.20505737
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19507427
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18972028
75pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.18211989
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17849359
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17677900
78establishment of protein localization to membrane (GO:0090150)3.17326334
79UTP biosynthetic process (GO:0006228)3.14757122
80negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.14643570
81pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.14193858
82spliceosomal snRNP assembly (GO:0000387)3.13778762
83protein targeting (GO:0006605)3.11976504
84purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.11035685
85purine nucleoside monophosphate biosynthetic process (GO:0009127)3.11035685
86protein maturation by protein folding (GO:0022417)3.08384477
87protein localization to endoplasmic reticulum (GO:0070972)3.08169290
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08075930
89regulation of cellular respiration (GO:0043457)3.08019819
90establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07476532
91protein deneddylation (GO:0000338)3.06781632
92deoxyribonucleotide catabolic process (GO:0009264)3.06742530
93deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.06461793
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06379993
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06379993
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06379993
97NADH metabolic process (GO:0006734)3.06350794
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06054144
99* generation of precursor metabolites and energy (GO:0006091)3.02649805
100positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.98600534
101calcium-mediated signaling using intracellular calcium source (GO:0035584)2.96265395
102guanosine-containing compound biosynthetic process (GO:1901070)2.92168244
103sarcomere organization (GO:0045214)2.88719845
104intracellular protein transmembrane import (GO:0044743)2.87157848
105heart contraction (GO:0060047)2.86675314
106heart process (GO:0003015)2.86675314
107substantia nigra development (GO:0021762)2.85073351
108regulation of cell communication by electrical coupling (GO:0010649)2.84191667
109cellular protein complex disassembly (GO:0043624)2.82016200
110regulation of cellular amino acid metabolic process (GO:0006521)2.81158455
111transcription elongation from RNA polymerase III promoter (GO:0006385)2.80148201
112termination of RNA polymerase III transcription (GO:0006386)2.80148201
113translational elongation (GO:0006414)2.79404338
114translation (GO:0006412)2.76746445
115quinone biosynthetic process (GO:1901663)2.74081025
116ubiquinone biosynthetic process (GO:0006744)2.74081025
117nucleoside diphosphate phosphorylation (GO:0006165)2.73773299
118mitochondrion morphogenesis (GO:0070584)2.72080162
119viral life cycle (GO:0019058)2.71369747
120UTP metabolic process (GO:0046051)2.70390109
121purine nucleoside biosynthetic process (GO:0042451)2.69279637
122purine ribonucleoside biosynthetic process (GO:0046129)2.69279637
123succinate metabolic process (GO:0006105)2.69030507
124regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.68349378
125regulation of protein kinase A signaling (GO:0010738)2.65911225
126detection of calcium ion (GO:0005513)2.65228837
127ribosomal small subunit assembly (GO:0000028)2.64932587
128cellular respiration (GO:0045333)2.64761261
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.64468323
130regulation of dopamine metabolic process (GO:0042053)2.63360994
131regulation of catecholamine metabolic process (GO:0042069)2.63360994
132positive regulation of action potential (GO:0045760)2.59664444
133regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57186939
134neuronal action potential propagation (GO:0019227)2.56121534
135short-term memory (GO:0007614)2.52943829
136regulation of relaxation of muscle (GO:1901077)2.52421887
137ubiquinone metabolic process (GO:0006743)2.51189764
138L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.50320554
139regulation of acyl-CoA biosynthetic process (GO:0050812)2.49679999
140muscle filament sliding (GO:0030049)2.49390781
141actin-myosin filament sliding (GO:0033275)2.49390781
142CTP metabolic process (GO:0046036)2.49268583
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.5642374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.96902606
2EZH2_22144423_ChIP-Seq_EOC_Human3.91166617
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.72261739
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54463510
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.18433798
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.15638377
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85411278
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.81476757
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.80237731
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62066007
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59156903
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52177345
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.49849094
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39356490
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21723978
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21708079
17VDR_22108803_ChIP-Seq_LS180_Human2.20428305
18GBX2_23144817_ChIP-Seq_PC3_Human2.16375780
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16179529
20TAF15_26573619_Chip-Seq_HEK293_Human2.14739185
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11269715
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07399564
23GABP_19822575_ChIP-Seq_HepG2_Human2.06883979
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.86816677
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.86453716
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86038040
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84532762
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83212513
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78233853
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.71030686
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64268466
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63784158
33* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63306320
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62366593
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60404818
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59633197
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59421750
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59252003
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59084018
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56606467
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.54919764
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54166984
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51248122
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51186781
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50000921
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48822055
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48661875
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.47850169
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46632065
50* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46451961
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45841284
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.42066523
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39590745
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.38310225
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.34997963
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33877811
57FOXP1_21924763_ChIP-Seq_HESCs_Human1.33862409
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.32785301
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31831196
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31683252
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31027087
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31027087
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31023096
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30942122
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29774447
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29658406
67FUS_26573619_Chip-Seq_HEK293_Human1.27622007
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25270433
69* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23573130
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.23181841
71REST_21632747_ChIP-Seq_MESCs_Mouse1.22583574
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22212307
73DCP1A_22483619_ChIP-Seq_HELA_Human1.20797230
74E2F7_22180533_ChIP-Seq_HELA_Human1.19659614
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19438192
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19229953
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17672902
78KDM5A_27292631_Chip-Seq_BREAST_Human1.17667177
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.17474805
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17278394
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.17259976
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17226720
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17043853
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16402710
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16178149
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15964638
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15607406
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14393240
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.13954881
90* BCL6_27268052_Chip-Seq_Bcells_Human1.11464782
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11180226
92CTCF_26484167_Chip-Seq_Bcells_Mouse1.10725828
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09744241
94ER_23166858_ChIP-Seq_MCF-7_Human1.09319098
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07396601
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06808906
97P300_19829295_ChIP-Seq_ESCs_Human1.06181655
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05864642
99* VDR_23849224_ChIP-Seq_CD4+_Human1.04700995
100TTF2_22483619_ChIP-Seq_HELA_Human1.04494386
101P68_20966046_ChIP-Seq_HELA_Human1.04386945
102ELK1_19687146_ChIP-ChIP_HELA_Human1.02268393
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01805567
104RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01241283
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01055380
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00799544
107IRF1_19129219_ChIP-ChIP_H3396_Human1.00685097
108CTCF_20526341_ChIP-Seq_ESCs_Human0.99646989
109RNF2_27304074_Chip-Seq_NSC_Mouse0.99114493
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98661213
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98298203
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97887443
113BP1_19119308_ChIP-ChIP_Hs578T_Human0.97659844
114CIITA_25753668_ChIP-Seq_RAJI_Human0.96674578
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95118208
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93888974
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93175811
118* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92971022
119VDR_21846776_ChIP-Seq_THP-1_Human0.92902354
120E2F1_20622854_ChIP-Seq_HELA_Human0.91450120
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91311830
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91266424
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91037555
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90966627
125ZNF274_21170338_ChIP-Seq_K562_Hela0.90478216
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90428591
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90109958
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89381551
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88623998
130MYC_18940864_ChIP-ChIP_HL60_Human0.88590517
131PHF8_20622854_ChIP-Seq_HELA_Human0.87428207
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87423068
133* BCOR_27268052_Chip-Seq_Bcells_Human0.86744293
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86287252
135CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86089369
136MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85904225
137SA1_27219007_Chip-Seq_Bcells_Human0.85250346
138MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84533077
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83527417
140ZNF263_19887448_ChIP-Seq_K562_Human0.82919873
141ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82734904
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82496468
143MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82046028
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81739591
145* XRN2_22483619_ChIP-Seq_HELA_Human0.81185548
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.81159000
147PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80950358
148* SA1_27219007_Chip-Seq_ERYTHROID_Human0.80882216
149SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80048950
150REST_19997604_ChIP-ChIP_NEURONS_Mouse0.79912469
151SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79585624
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79321679
153IGF1R_20145208_ChIP-Seq_DFB_Human0.79162259
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79078113
155JUN_21703547_ChIP-Seq_K562_Human0.78548242
156PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77880223
157FOXP3_21729870_ChIP-Seq_TREG_Human0.77106730
158PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.75871607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.92608957
2MP0003880_abnormal_central_pattern4.26022221
3MP0003806_abnormal_nucleotide_metabolis3.62872558
4MP0001529_abnormal_vocalization3.42374958
5MP0003186_abnormal_redox_activity3.35904210
6MP0009379_abnormal_foot_pigmentation3.13793621
7MP0006276_abnormal_autonomic_nervous2.92832998
8MP0003646_muscle_fatigue2.91975890
9MP0006292_abnormal_olfactory_placode2.89168510
10MP0000751_myopathy2.83831512
11MP0004215_abnormal_myocardial_fiber2.59661696
12MP0001905_abnormal_dopamine_level2.49290522
13MP0010030_abnormal_orbit_morphology2.46502195
14MP0006036_abnormal_mitochondrial_physio2.26364992
15MP0004084_abnormal_cardiac_muscle2.20846027
16MP0004036_abnormal_muscle_relaxation2.20733265
17MP0001968_abnormal_touch/_nociception2.19796894
18MP0002938_white_spotting2.16598328
19MP0002736_abnormal_nociception_after2.16346894
20MP0000749_muscle_degeneration2.15906140
21MP0003786_premature_aging2.06538412
22MP0003136_yellow_coat_color2.03373881
23MP0002653_abnormal_ependyma_morphology2.02001547
24MP0008058_abnormal_DNA_repair1.99968939
25MP0009046_muscle_twitch1.96067609
26MP0003693_abnormal_embryo_hatching1.94516132
27MP0004142_abnormal_muscle_tone1.94197158
28MP0003137_abnormal_impulse_conducting1.92363349
29MP0002272_abnormal_nervous_system1.92009053
30MP0009745_abnormal_behavioral_response1.91701807
31MP0006035_abnormal_mitochondrial_morpho1.89644074
32MP0002064_seizures1.87851595
33MP0003011_delayed_dark_adaptation1.86581547
34MP0005330_cardiomyopathy1.79152823
35MP0001440_abnormal_grooming_behavior1.77167009
36MP0003635_abnormal_synaptic_transmissio1.76908059
37MP0002735_abnormal_chemical_nociception1.76213364
38MP0004145_abnormal_muscle_electrophysio1.71386259
39MP0002822_catalepsy1.68186321
40MP0002734_abnormal_mechanical_nocicepti1.63652763
41MP0002572_abnormal_emotion/affect_behav1.56958945
42MP0008875_abnormal_xenobiotic_pharmacok1.54260947
43MP0008995_early_reproductive_senescence1.52399188
44MP0001188_hyperpigmentation1.52186398
45MP0005084_abnormal_gallbladder_morpholo1.50445840
46MP0002972_abnormal_cardiac_muscle1.49420472
47MP0003123_paternal_imprinting1.48749937
48MP0001970_abnormal_pain_threshold1.43696266
49MP0004085_abnormal_heartbeat1.43005523
50MP0002332_abnormal_exercise_endurance1.42792187
51MP0008932_abnormal_embryonic_tissue1.40876930
52MP0001764_abnormal_homeostasis1.40129956
53MP0005386_behavior/neurological_phenoty1.39915156
54MP0004924_abnormal_behavior1.39915156
55MP0002638_abnormal_pupillary_reflex1.39226358
56MP0002067_abnormal_sensory_capabilities1.37539897
57MP0002163_abnormal_gland_morphology1.34436945
58MP0003122_maternal_imprinting1.33980225
59MP0001486_abnormal_startle_reflex1.33712597
60MP0010386_abnormal_urinary_bladder1.32637440
61MP0002063_abnormal_learning/memory/cond1.32560582
62MP0005620_abnormal_muscle_contractility1.31756508
63MP0004484_altered_response_of1.30944845
64MP0004957_abnormal_blastocyst_morpholog1.30697500
65MP0004270_analgesia1.30167687
66MP0000049_abnormal_middle_ear1.29516219
67MP0005670_abnormal_white_adipose1.28022541
68MP0001501_abnormal_sleep_pattern1.27956024
69MP0002733_abnormal_thermal_nociception1.27881866
70MP0005409_darkened_coat_color1.25726503
71MP0004859_abnormal_synaptic_plasticity1.24168479
72MP0003718_maternal_effect1.22323534
73MP0000750_abnormal_muscle_regeneration1.18971583
74MP0005394_taste/olfaction_phenotype1.18170494
75MP0005499_abnormal_olfactory_system1.18170494
76MP0002876_abnormal_thyroid_physiology1.16908650
77MP0002106_abnormal_muscle_physiology1.16319099
78MP0004043_abnormal_pH_regulation1.15374002
79MP0005332_abnormal_amino_acid1.15052811
80MP0001293_anophthalmia1.14870755
81MP0005379_endocrine/exocrine_gland_phen1.14346549
82MP0005423_abnormal_somatic_nervous1.13852137
83MP0002184_abnormal_innervation1.12461234
84MP0006072_abnormal_retinal_apoptosis1.12154717
85MP0005377_hearing/vestibular/ear_phenot1.11595078
86MP0003878_abnormal_ear_physiology1.11595078
87MP0000358_abnormal_cell_content/1.11032631
88MP0001984_abnormal_olfaction1.10031827
89MP0002234_abnormal_pharynx_morphology1.09507144
90MP0001986_abnormal_taste_sensitivity1.07834318
91MP0000013_abnormal_adipose_tissue1.06386363
92MP0005075_abnormal_melanosome_morpholog1.06130526
93MP0005171_absent_coat_pigmentation1.05669988
94MP0003077_abnormal_cell_cycle1.04964389
95MP0002095_abnormal_skin_pigmentation1.03166044
96MP0002127_abnormal_cardiovascular_syste1.02579913
97MP0005369_muscle_phenotype1.02521060
98MP0008775_abnormal_heart_ventricle1.01188486
99MP0001544_abnormal_cardiovascular_syste1.01122939
100MP0005385_cardiovascular_system_phenoty1.01122939
101MP0000372_irregular_coat_pigmentation1.00433475
102MP0001485_abnormal_pinna_reflex0.99887523
103MP0006138_congestive_heart_failure0.99815437
104MP0002557_abnormal_social/conspecific_i0.99798874
105MP0003111_abnormal_nucleus_morphology0.99264108
106MP0001727_abnormal_embryo_implantation0.99237289
107MP0002282_abnormal_trachea_morphology0.98911897
108MP0000778_abnormal_nervous_system0.98317535
109MP0005408_hypopigmentation0.97938473
110MP0002160_abnormal_reproductive_system0.97706395
111MP0002102_abnormal_ear_morphology0.94912097
112MP0005174_abnormal_tail_pigmentation0.94448992
113MP0000747_muscle_weakness0.90726165
114MP0008007_abnormal_cellular_replicative0.90528783
115MP0004133_heterotaxia0.90057394
116MP0005645_abnormal_hypothalamus_physiol0.89690511
117MP0010094_abnormal_chromosome_stability0.89223672
118MP0003938_abnormal_ear_development0.87852796
119MP0004742_abnormal_vestibular_system0.87501932
120MP0002066_abnormal_motor_capabilities/c0.87284515
121MP0001664_abnormal_digestion0.87027688
122MP0004087_abnormal_muscle_fiber0.85096031
123MP0005266_abnormal_metabolism0.85012016
124MP0005410_abnormal_fertilization0.84088251
125MP0000230_abnormal_systemic_arterial0.83921686
126MP0000759_abnormal_skeletal_muscle0.83157246
127MP0005551_abnormal_eye_electrophysiolog0.83043401
128MP0005253_abnormal_eye_physiology0.81424714
129MP0001756_abnormal_urination0.80509929
130MP0001963_abnormal_hearing_physiology0.80228429
131MP0000026_abnormal_inner_ear0.79896230
132MP0002751_abnormal_autonomic_nervous0.78289498
133MP0001919_abnormal_reproductive_system0.78266513
134MP0002752_abnormal_somatic_nervous0.77807279
135MP0002229_neurodegeneration0.77473035
136MP0009333_abnormal_splenocyte_physiolog0.77242282
137MP0005636_abnormal_mineral_homeostasis0.77182775
138MP0005535_abnormal_body_temperature0.76938180
139MP0003315_abnormal_perineum_morphology0.76861505
140MP0001346_abnormal_lacrimal_gland0.76580559
141MP0000631_abnormal_neuroendocrine_gland0.76444366
142MP0002132_abnormal_respiratory_system0.76422287
143MP0000538_abnormal_urinary_bladder0.75343153
144MP0005389_reproductive_system_phenotype0.75292277
145MP0002210_abnormal_sex_determination0.75287243
146MP0002882_abnormal_neuron_morphology0.74206481
147MP0004147_increased_porphyrin_level0.73078148
148MP0002277_abnormal_respiratory_mucosa0.72676591
149MP0008872_abnormal_physiological_respon0.71406302
150MP0003941_abnormal_skin_development0.71283242
151MP0003638_abnormal_response/metabolism_0.70719456
152MP0005646_abnormal_pituitary_gland0.69546714
153MP0008789_abnormal_olfactory_epithelium0.69186557
154MP0003950_abnormal_plasma_membrane0.69078349
155MP0000566_synostosis0.64757259
156MP0000343_altered_response_to0.64565512
157MP0001324_abnormal_eye_pigmentation0.64084259

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)7.65728207
2* Abnormal mitochondria in muscle tissue (HP:0008316)6.95248458
3* Mitochondrial inheritance (HP:0001427)6.72918729
4* Progressive macrocephaly (HP:0004481)6.36906838
5* Acute encephalopathy (HP:0006846)6.17580689
6Hepatocellular necrosis (HP:0001404)6.02648170
7* Increased CSF lactate (HP:0002490)5.73064096
8Hepatic necrosis (HP:0002605)5.33317074
9Increased hepatocellular lipid droplets (HP:0006565)4.92601134
10Reticulocytopenia (HP:0001896)4.82764007
11Lipid accumulation in hepatocytes (HP:0006561)4.52201041
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.29473093
13* Cerebral edema (HP:0002181)4.28832818
14Renal Fanconi syndrome (HP:0001994)4.18404470
15* Respiratory failure (HP:0002878)4.04458042
16* Exercise intolerance (HP:0003546)4.01366261
17Increased intramyocellular lipid droplets (HP:0012240)3.97359741
18* Lactic acidosis (HP:0003128)3.91942038
19* Optic disc pallor (HP:0000543)3.90932731
20Increased serum pyruvate (HP:0003542)3.85303172
21Abnormality of glycolysis (HP:0004366)3.85303172
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.82155607
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.66450116
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.66450116
25Increased serum lactate (HP:0002151)3.55994408
26Increased muscle lipid content (HP:0009058)3.48292069
27* Leukodystrophy (HP:0002415)3.46557005
283-Methylglutaconic aciduria (HP:0003535)3.35468457
29Sudden death (HP:0001699)3.34607239
30Aplasia/Hypoplasia of the sacrum (HP:0008517)3.33883419
31Pheochromocytoma (HP:0002666)3.22101139
32Neuroendocrine neoplasm (HP:0100634)3.19670292
33Muscle hypertrophy of the lower extremities (HP:0008968)3.13822923
34Exertional dyspnea (HP:0002875)3.13349879
35Calf muscle hypertrophy (HP:0008981)3.03767808
36Pallor (HP:0000980)3.03573471
37Testicular atrophy (HP:0000029)3.02904582
38Respiratory difficulties (HP:0002880)2.85115629
39Type I transferrin isoform profile (HP:0003642)2.78487886
40Abnormality of renal resorption (HP:0011038)2.77921013
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.76509630
42Focal motor seizures (HP:0011153)2.69675500
43CNS demyelination (HP:0007305)2.61080541
44Palpitations (HP:0001962)2.59989816
45Generalized aminoaciduria (HP:0002909)2.58951494
46Emotional lability (HP:0000712)2.58325296
47* X-linked dominant inheritance (HP:0001423)2.54070954
48Myokymia (HP:0002411)2.46989325
49Parakeratosis (HP:0001036)2.46010567
50Abnormality of cells of the erythroid lineage (HP:0012130)2.45146365
51Dicarboxylic aciduria (HP:0003215)2.34726590
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34726590
53Hyperphosphaturia (HP:0003109)2.33310120
54Congenital, generalized hypertrichosis (HP:0004540)2.25888199
55Abnormality of the calf musculature (HP:0001430)2.25390817
56Aplastic anemia (HP:0001915)2.21882393
57Abnormality of urine glucose concentration (HP:0011016)2.20775351
58Glycosuria (HP:0003076)2.20775351
59Ventricular tachycardia (HP:0004756)2.18600127
60* Lethargy (HP:0001254)2.17543760
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15151566
62Abnormal protein N-linked glycosylation (HP:0012347)2.15151566
63Abnormal protein glycosylation (HP:0012346)2.15151566
64Abnormal glycosylation (HP:0012345)2.15151566
65Syncope (HP:0001279)2.14210821
66Myotonia (HP:0002486)2.12524903
67Atonic seizures (HP:0010819)2.12262792
68Amniotic constriction ring (HP:0009775)2.07751772
69Abnormality of placental membranes (HP:0011409)2.07751772
70Abnormal number of erythroid precursors (HP:0012131)2.07545804
71Progressive external ophthalmoplegia (HP:0000590)2.06663433
72Conjunctival hamartoma (HP:0100780)2.05902341
73Prolonged QT interval (HP:0001657)2.01974022
74Pancytopenia (HP:0001876)2.00782111
75Atrial fibrillation (HP:0005110)2.00049479
76Abnormal pupillary function (HP:0007686)1.96256373
77Supraventricular tachycardia (HP:0004755)1.95970224
78Exercise-induced myalgia (HP:0003738)1.95120814
79Hyperglycinemia (HP:0002154)1.94034122
80Rib fusion (HP:0000902)1.92751817
81Primary atrial arrhythmia (HP:0001692)1.92306304
82Absent thumb (HP:0009777)1.92258012
83Microvesicular hepatic steatosis (HP:0001414)1.92252262
84Abnormal urine phosphate concentration (HP:0012599)1.91580079
85Microretrognathia (HP:0000308)1.91528100
86Pancreatic fibrosis (HP:0100732)1.91315825
87Hypoplastic left heart (HP:0004383)1.89390232
88Macrocytic anemia (HP:0001972)1.89007679
89Muscle fiber splitting (HP:0003555)1.88991433
90Supraventricular arrhythmia (HP:0005115)1.87546347
91Limb dystonia (HP:0002451)1.86460545
92Colon cancer (HP:0003003)1.86179805
93Hypothermia (HP:0002045)1.85192789
94Opisthotonus (HP:0002179)1.84854532
95Sclerocornea (HP:0000647)1.84363153
96Congenital ichthyosiform erythroderma (HP:0007431)1.82962871
97Lipoatrophy (HP:0100578)1.82612369
98Cerebral hemorrhage (HP:0001342)1.81848343
99Abnormality of midbrain morphology (HP:0002418)1.81251898
100Molar tooth sign on MRI (HP:0002419)1.81251898
101Pancreatic cysts (HP:0001737)1.80986709
102Progressive microcephaly (HP:0000253)1.80859375
103Cerebral hypomyelination (HP:0006808)1.79163547
104Medial flaring of the eyebrow (HP:0010747)1.78724010
105Muscle fiber atrophy (HP:0100295)1.77889559
106Rough bone trabeculation (HP:0100670)1.77634163
107Gliosis (HP:0002171)1.77068060
108Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76484263
109Septo-optic dysplasia (HP:0100842)1.74777907
110Partial duplication of thumb phalanx (HP:0009944)1.74709816
111Poor suck (HP:0002033)1.74088582
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.74010968
113Abnormality of alanine metabolism (HP:0010916)1.74010968
114Hyperalaninemia (HP:0003348)1.74010968
115Congenital malformation of the right heart (HP:0011723)1.72993840
116Double outlet right ventricle (HP:0001719)1.72993840
117Methylmalonic aciduria (HP:0012120)1.72307593
118Renal tubular dysfunction (HP:0000124)1.71922914
119Oral leukoplakia (HP:0002745)1.70931271
120Left ventricular hypertrophy (HP:0001712)1.69439049
121Hyperventilation (HP:0002883)1.69127560
122Ragged-red muscle fibers (HP:0003200)1.68989384
123Progressive muscle weakness (HP:0003323)1.68481115
124* Vomiting (HP:0002013)1.67140431
125Cleft eyelid (HP:0000625)1.66341292
126Reduced antithrombin III activity (HP:0001976)1.66141708
127Abnormality of the vocal cords (HP:0008777)1.65305932
128Neoplasm of head and neck (HP:0012288)1.64259565
129Esophageal neoplasm (HP:0100751)1.64259565
130* Blindness (HP:0000618)1.63096256
131Anxiety (HP:0000739)1.62406796
132Exercise-induced muscle cramps (HP:0003710)1.62376044
133Absence seizures (HP:0002121)1.62210979
134Severe visual impairment (HP:0001141)1.61515015
135Partial duplication of the phalanx of hand (HP:0009999)1.61443741
136Degeneration of anterior horn cells (HP:0002398)1.60611446
137Abnormality of the anterior horn cell (HP:0006802)1.60611446
138Gait imbalance (HP:0002141)1.60564225
139True hermaphroditism (HP:0010459)1.60311553
140Methylmalonic acidemia (HP:0002912)1.60227346
141Aplasia/hypoplasia of the uterus (HP:0008684)1.60051321
142Muscle stiffness (HP:0003552)1.59237904
143Type 2 muscle fiber atrophy (HP:0003554)1.59028639
144Hypoplastic heart (HP:0001961)1.58881450
145Unsteady gait (HP:0002317)1.58640693
146Decreased electroretinogram (ERG) amplitude (HP:0000654)1.58061915
147Retinal dysplasia (HP:0007973)1.57859941
148Maternal diabetes (HP:0009800)1.57680399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.58398245
2NME13.75762934
3MAP3K123.41984546
4MYLK3.23749275
5CASK3.10474138
6STK162.44832779
7NME22.39157775
8TESK22.37618313
9GRK72.29080189
10ARAF2.23026073
11OBSCN2.22610587
12TLK12.12745013
13STK392.05054229
14CDK192.03568669
15PNCK2.01211797
16MST42.00267240
17MAP2K71.90372952
18TESK11.87840235
19GRK51.86577346
20CDC71.86055889
21MUSK1.83762198
22LIMK11.79068108
23KDR1.78111168
24WNK41.66398257
25MAP4K21.57721469
26OXSR11.52397955
27PHKG21.49307674
28PHKG11.49307674
29BRAF1.49297291
30BCR1.47021344
31MAP3K41.40834166
32INSRR1.39581970
33PDK41.38691489
34PDK31.38691489
35CAMK2D1.34149614
36BCKDK1.26616056
37LRRK21.26542717
38BUB11.26540474
39BMPR1B1.25876955
40ADRBK21.23254917
41LMTK21.18883181
42CAMK2A1.15744513
43VRK11.15642657
44PBK1.15538139
45MARK11.13767689
46NTRK31.13693834
47TNIK1.12957424
48CAMK2B1.12417124
49DAPK31.11272073
50NUAK11.09606561
51TAF11.08755298
52PLK21.07868911
53EPHA41.07576008
54BRSK11.06412315
55EIF2AK11.05094691
56BMPR21.01758243
57MAPK131.00801594
58MINK10.98068477
59DYRK30.97698460
60ADRBK10.94988797
61NEK10.94728000
62CAMK2G0.94178160
63UHMK10.93841579
64PINK10.93117141
65RPS6KA50.91208666
66PRKCE0.90247471
67DYRK20.89947642
68WNK30.89559946
69PDK20.87321050
70PKN10.87054158
71ROCK20.86695134
72STK240.86496300
73PIM20.85929582
74MAP2K40.85925765
75MAPKAPK50.83155634
76PIK3CA0.82710348
77AURKB0.81526087
78ILK0.81249207
79SRPK10.74952709
80CHEK20.74091138
81CCNB10.72576778
82GRK10.72486377
83PLK10.71933641
84ABL20.70708653
85PRKCG0.70026014
86PAK10.69998338
87PRKACA0.68240562
88CSNK1G30.67818747
89CDK80.66777321
90ZAK0.64674776
91TSSK60.62483660
92STK40.61314774
93WEE10.60243109
94CSNK1G20.58671025
95PLK30.58001677
96STK38L0.57649314
97EIF2AK30.57390165
98PLK40.56505483
99CDK140.55168371
100TAOK20.53709281
101AKT30.53443791
102CSNK1G10.53286483
103MAPKAPK30.52981341
104FGR0.52470763
105CDC42BPA0.50484732
106ATR0.49202257
107ROCK10.48574648
108PAK30.48290322
109PTK2B0.47384580
110CDK180.47276449
111AURKA0.47128950
112FES0.46551940
113CDK11A0.46512140
114EPHB20.46087382
115MAPK150.45033548
116NTRK20.44959173
117CDK50.44228727
118CDK150.43569777
119CSNK1A1L0.43204886
120PRKCI0.43019822
121DAPK10.41700343
122TTN0.41633364
123CDK70.39020840
124SCYL20.38948923
125IRAK20.38564417
126PRPF4B0.37742830
127IRAK30.35891547
128CSNK2A10.34976873
129WNK10.34755117
130GRK60.33706142
131IKBKB0.33109445
132PAK40.32904244
133MAPK120.32741157
134MAP3K110.32489709
135AKT20.32377211
136TIE10.32146289
137CSNK2A20.31434840
138BMX0.25705652
139CSNK1A10.25027627
140BRSK20.24113016
141PASK0.21496581
142CAMK10.20820600
143PRKCD0.18727422

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.88308082
2Parkinsons disease_Homo sapiens_hsa050125.88135130
3Alzheimers disease_Homo sapiens_hsa050104.48327264
4Huntingtons disease_Homo sapiens_hsa050164.12974402
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.61703076
6Cardiac muscle contraction_Homo sapiens_hsa042603.57054416
7Ribosome_Homo sapiens_hsa030103.38625473
8Proteasome_Homo sapiens_hsa030502.95361014
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.52421964
10DNA replication_Homo sapiens_hsa030302.49209158
11Collecting duct acid secretion_Homo sapiens_hsa049662.23377281
12Protein export_Homo sapiens_hsa030602.21285359
13Mismatch repair_Homo sapiens_hsa034302.11751449
14RNA polymerase_Homo sapiens_hsa030201.95537126
15Base excision repair_Homo sapiens_hsa034101.85757057
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63657511
17Fatty acid elongation_Homo sapiens_hsa000621.59664899
18Nicotine addiction_Homo sapiens_hsa050331.50246589
19Folate biosynthesis_Homo sapiens_hsa007901.43918571
20Vibrio cholerae infection_Homo sapiens_hsa051101.42960149
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39821229
22Synaptic vesicle cycle_Homo sapiens_hsa047211.34116447
23Pyruvate metabolism_Homo sapiens_hsa006201.31117138
24Sulfur metabolism_Homo sapiens_hsa009201.27391720
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22172364
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10076397
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09838151
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09102191
29One carbon pool by folate_Homo sapiens_hsa006701.08259884
30Propanoate metabolism_Homo sapiens_hsa006401.08201420
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97767291
32Fanconi anemia pathway_Homo sapiens_hsa034600.96917123
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96590486
34Taste transduction_Homo sapiens_hsa047420.93333985
35Butanoate metabolism_Homo sapiens_hsa006500.88434369
36Pyrimidine metabolism_Homo sapiens_hsa002400.86028755
37Carbon metabolism_Homo sapiens_hsa012000.84893224
38Serotonergic synapse_Homo sapiens_hsa047260.84456692
39* Metabolic pathways_Homo sapiens_hsa011000.81260703
40GABAergic synapse_Homo sapiens_hsa047270.80972345
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74807685
42Biosynthesis of amino acids_Homo sapiens_hsa012300.74410003
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73021859
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72859533
45Rheumatoid arthritis_Homo sapiens_hsa053230.70874965
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70389086
47Dilated cardiomyopathy_Homo sapiens_hsa054140.70317366
48Phenylalanine metabolism_Homo sapiens_hsa003600.69235452
49RNA transport_Homo sapiens_hsa030130.68338329
50Tyrosine metabolism_Homo sapiens_hsa003500.66445081
51Phototransduction_Homo sapiens_hsa047440.62370582
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62282099
53Morphine addiction_Homo sapiens_hsa050320.59815991
54Purine metabolism_Homo sapiens_hsa002300.59292313
55Amphetamine addiction_Homo sapiens_hsa050310.58588691
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58012895
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.55416332
58Glutathione metabolism_Homo sapiens_hsa004800.54659548
59Systemic lupus erythematosus_Homo sapiens_hsa053220.54087670
60Vitamin B6 metabolism_Homo sapiens_hsa007500.53975521
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53400096
62Calcium signaling pathway_Homo sapiens_hsa040200.52041564
63Circadian entrainment_Homo sapiens_hsa047130.50961336
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.49586995
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.48986040
66Arachidonic acid metabolism_Homo sapiens_hsa005900.48396616
67Chemical carcinogenesis_Homo sapiens_hsa052040.48377422
68Dopaminergic synapse_Homo sapiens_hsa047280.48187096
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47961198
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.46613519
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45883559
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45453805
73Tryptophan metabolism_Homo sapiens_hsa003800.44926303
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44374565
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44006779
76Glutamatergic synapse_Homo sapiens_hsa047240.42424268
77Sulfur relay system_Homo sapiens_hsa041220.41678571
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41095016
79Pentose phosphate pathway_Homo sapiens_hsa000300.40076656
80N-Glycan biosynthesis_Homo sapiens_hsa005100.39337172
81Long-term depression_Homo sapiens_hsa047300.38694008
82Long-term potentiation_Homo sapiens_hsa047200.38187348
83Olfactory transduction_Homo sapiens_hsa047400.37442603
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36253089
85Insulin secretion_Homo sapiens_hsa049110.36039087
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35895610
87Basal transcription factors_Homo sapiens_hsa030220.34809583
88Cocaine addiction_Homo sapiens_hsa050300.34606650
89Arginine and proline metabolism_Homo sapiens_hsa003300.33951713
90Ether lipid metabolism_Homo sapiens_hsa005650.33907452
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33606861
92Renin secretion_Homo sapiens_hsa049240.32990075
93Linoleic acid metabolism_Homo sapiens_hsa005910.32382330
94Phagosome_Homo sapiens_hsa041450.31123467
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29777056
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29274251
97Cell cycle_Homo sapiens_hsa041100.28354918
98Fructose and mannose metabolism_Homo sapiens_hsa000510.28303793
99Fat digestion and absorption_Homo sapiens_hsa049750.27977160
100Cholinergic synapse_Homo sapiens_hsa047250.27518769
101Nucleotide excision repair_Homo sapiens_hsa034200.27454361
102Salivary secretion_Homo sapiens_hsa049700.27000970
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.26255536
104Regulation of autophagy_Homo sapiens_hsa041400.25679261
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25525212
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25221412
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.24842989
108Peroxisome_Homo sapiens_hsa041460.23569364
109Spliceosome_Homo sapiens_hsa030400.23459080
110Gastric acid secretion_Homo sapiens_hsa049710.23037337
111Basal cell carcinoma_Homo sapiens_hsa052170.22390219
112Vitamin digestion and absorption_Homo sapiens_hsa049770.22266831
113Alcoholism_Homo sapiens_hsa050340.21847184
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21768809
115Fatty acid metabolism_Homo sapiens_hsa012120.20993876
116beta-Alanine metabolism_Homo sapiens_hsa004100.19810929
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.19055717
118Epstein-Barr virus infection_Homo sapiens_hsa051690.18969203
119Sphingolipid metabolism_Homo sapiens_hsa006000.18708882
120Selenocompound metabolism_Homo sapiens_hsa004500.18457513
121Oxytocin signaling pathway_Homo sapiens_hsa049210.18414542
122Galactose metabolism_Homo sapiens_hsa000520.17636794
123Steroid biosynthesis_Homo sapiens_hsa001000.17530980
124Nitrogen metabolism_Homo sapiens_hsa009100.17428442
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17279705
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.16800688
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16060098
128Homologous recombination_Homo sapiens_hsa034400.15879697
129Gap junction_Homo sapiens_hsa045400.15507566
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.13633375
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13618554
132Type I diabetes mellitus_Homo sapiens_hsa049400.12554226
133Fatty acid degradation_Homo sapiens_hsa000710.11940514
134RNA degradation_Homo sapiens_hsa030180.11154680
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11091903

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