Rank | Gene Set | Z-score |
---|---|---|
1 | ATP synthesis coupled proton transport (GO:0015986) | 9.87429162 |
2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 9.87429162 |
3 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 9.32668109 |
4 | * respiratory electron transport chain (GO:0022904) | 8.30837701 |
5 | * electron transport chain (GO:0022900) | 8.09686132 |
6 | protein complex biogenesis (GO:0070271) | 5.67587412 |
7 | chaperone-mediated protein transport (GO:0072321) | 5.53342891 |
8 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.52163469 |
9 | maturation of SSU-rRNA (GO:0030490) | 5.46910938 |
10 | ATP biosynthetic process (GO:0006754) | 5.43986422 |
11 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 5.34632566 |
12 | NADH dehydrogenase complex assembly (GO:0010257) | 5.34632566 |
13 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 5.34632566 |
14 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 5.30759918 |
15 | protein neddylation (GO:0045116) | 5.23254500 |
16 | hydrogen ion transmembrane transport (GO:1902600) | 5.14383056 |
17 | mitochondrial respiratory chain complex assembly (GO:0033108) | 5.14042879 |
18 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 5.09051744 |
19 | translational initiation (GO:0006413) | 5.03551101 |
20 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.99133708 |
21 | oxidative phosphorylation (GO:0006119) | 4.88787069 |
22 | inner mitochondrial membrane organization (GO:0007007) | 4.78774050 |
23 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.74340213 |
24 | protein complex disassembly (GO:0043241) | 4.70442465 |
25 | proton transport (GO:0015992) | 4.47663237 |
26 | ribosomal large subunit biogenesis (GO:0042273) | 4.44091236 |
27 | macromolecular complex disassembly (GO:0032984) | 4.43878481 |
28 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 4.42476192 |
29 | hydrogen transport (GO:0006818) | 4.38771781 |
30 | protein targeting to membrane (GO:0006612) | 4.34292998 |
31 | regulation of mitochondrial translation (GO:0070129) | 4.29738418 |
32 | regulation of oxidative phosphorylation (GO:0002082) | 3.90391994 |
33 | cellular component biogenesis (GO:0044085) | 3.90180260 |
34 | ribosomal small subunit biogenesis (GO:0042274) | 3.87488542 |
35 | GTP biosynthetic process (GO:0006183) | 3.86780368 |
36 | respiratory chain complex IV assembly (GO:0008535) | 3.83025478 |
37 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.81579650 |
38 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.80634564 |
39 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.76116872 |
40 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.76116872 |
41 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.75666946 |
42 | cytochrome complex assembly (GO:0017004) | 3.72089349 |
43 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.69933035 |
44 | sequestering of actin monomers (GO:0042989) | 3.63387586 |
45 | mRNA catabolic process (GO:0006402) | 3.55703006 |
46 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.53167156 |
47 | viral transcription (GO:0019083) | 3.52920734 |
48 | establishment of protein localization to mitochondrion (GO:0072655) | 3.48129578 |
49 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.47081519 |
50 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.46372301 |
51 | negative regulation of ligase activity (GO:0051352) | 3.46372301 |
52 | tricarboxylic acid cycle (GO:0006099) | 3.45662456 |
53 | cullin deneddylation (GO:0010388) | 3.45543159 |
54 | peptidyl-histidine modification (GO:0018202) | 3.45448237 |
55 | protein targeting to mitochondrion (GO:0006626) | 3.45297138 |
56 | proteasome assembly (GO:0043248) | 3.41455449 |
57 | CTP biosynthetic process (GO:0006241) | 3.40518505 |
58 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.40467290 |
59 | aerobic respiration (GO:0009060) | 3.38957102 |
60 | mitochondrial transport (GO:0006839) | 3.38554452 |
61 | translational termination (GO:0006415) | 3.38489375 |
62 | dopamine transport (GO:0015872) | 3.38027251 |
63 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.31932596 |
64 | protein-cofactor linkage (GO:0018065) | 3.31459562 |
65 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.29656466 |
66 | cotranslational protein targeting to membrane (GO:0006613) | 3.28488976 |
67 | protein localization to mitochondrion (GO:0070585) | 3.27731199 |
68 | pseudouridine synthesis (GO:0001522) | 3.25477089 |
69 | base-excision repair, AP site formation (GO:0006285) | 3.24104485 |
70 | RNA catabolic process (GO:0006401) | 3.23263991 |
71 | rRNA modification (GO:0000154) | 3.23208423 |
72 | protein targeting to ER (GO:0045047) | 3.20505737 |
73 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.19507427 |
74 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.18972028 |
75 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.18211989 |
76 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.17849359 |
77 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.17677900 |
78 | establishment of protein localization to membrane (GO:0090150) | 3.17326334 |
79 | UTP biosynthetic process (GO:0006228) | 3.14757122 |
80 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.14643570 |
81 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.14193858 |
82 | spliceosomal snRNP assembly (GO:0000387) | 3.13778762 |
83 | protein targeting (GO:0006605) | 3.11976504 |
84 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.11035685 |
85 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.11035685 |
86 | protein maturation by protein folding (GO:0022417) | 3.08384477 |
87 | protein localization to endoplasmic reticulum (GO:0070972) | 3.08169290 |
88 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.08075930 |
89 | regulation of cellular respiration (GO:0043457) | 3.08019819 |
90 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.07476532 |
91 | protein deneddylation (GO:0000338) | 3.06781632 |
92 | deoxyribonucleotide catabolic process (GO:0009264) | 3.06742530 |
93 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.06461793 |
94 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.06379993 |
95 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.06379993 |
96 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.06379993 |
97 | NADH metabolic process (GO:0006734) | 3.06350794 |
98 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.06054144 |
99 | * generation of precursor metabolites and energy (GO:0006091) | 3.02649805 |
100 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 2.98600534 |
101 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 2.96265395 |
102 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.92168244 |
103 | sarcomere organization (GO:0045214) | 2.88719845 |
104 | intracellular protein transmembrane import (GO:0044743) | 2.87157848 |
105 | heart contraction (GO:0060047) | 2.86675314 |
106 | heart process (GO:0003015) | 2.86675314 |
107 | substantia nigra development (GO:0021762) | 2.85073351 |
108 | regulation of cell communication by electrical coupling (GO:0010649) | 2.84191667 |
109 | cellular protein complex disassembly (GO:0043624) | 2.82016200 |
110 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.81158455 |
111 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.80148201 |
112 | termination of RNA polymerase III transcription (GO:0006386) | 2.80148201 |
113 | translational elongation (GO:0006414) | 2.79404338 |
114 | translation (GO:0006412) | 2.76746445 |
115 | quinone biosynthetic process (GO:1901663) | 2.74081025 |
116 | ubiquinone biosynthetic process (GO:0006744) | 2.74081025 |
117 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.73773299 |
118 | mitochondrion morphogenesis (GO:0070584) | 2.72080162 |
119 | viral life cycle (GO:0019058) | 2.71369747 |
120 | UTP metabolic process (GO:0046051) | 2.70390109 |
121 | purine nucleoside biosynthetic process (GO:0042451) | 2.69279637 |
122 | purine ribonucleoside biosynthetic process (GO:0046129) | 2.69279637 |
123 | succinate metabolic process (GO:0006105) | 2.69030507 |
124 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 2.68349378 |
125 | regulation of protein kinase A signaling (GO:0010738) | 2.65911225 |
126 | detection of calcium ion (GO:0005513) | 2.65228837 |
127 | ribosomal small subunit assembly (GO:0000028) | 2.64932587 |
128 | cellular respiration (GO:0045333) | 2.64761261 |
129 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.64468323 |
130 | regulation of dopamine metabolic process (GO:0042053) | 2.63360994 |
131 | regulation of catecholamine metabolic process (GO:0042069) | 2.63360994 |
132 | positive regulation of action potential (GO:0045760) | 2.59664444 |
133 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.57186939 |
134 | neuronal action potential propagation (GO:0019227) | 2.56121534 |
135 | short-term memory (GO:0007614) | 2.52943829 |
136 | regulation of relaxation of muscle (GO:1901077) | 2.52421887 |
137 | ubiquinone metabolic process (GO:0006743) | 2.51189764 |
138 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.50320554 |
139 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 2.49679999 |
140 | muscle filament sliding (GO:0030049) | 2.49390781 |
141 | actin-myosin filament sliding (GO:0033275) | 2.49390781 |
142 | CTP metabolic process (GO:0046036) | 2.49268583 |
143 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 10.5642374 |
Rank | Gene Set | Z-score |
---|---|---|
1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.96902606 |
2 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.91166617 |
3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.72261739 |
4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.54463510 |
5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.18433798 |
6 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.15638377 |
7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.85411278 |
8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.81476757 |
9 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.80237731 |
10 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.62066007 |
11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.59156903 |
12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.52177345 |
13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.49849094 |
14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.39356490 |
15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.21723978 |
16 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.21708079 |
17 | VDR_22108803_ChIP-Seq_LS180_Human | 2.20428305 |
18 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.16375780 |
19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.16179529 |
20 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.14739185 |
21 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 2.11269715 |
22 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.07399564 |
23 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.06883979 |
24 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.86816677 |
25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.86453716 |
26 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.86038040 |
27 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.84532762 |
28 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.83212513 |
29 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.78233853 |
30 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.71030686 |
31 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.64268466 |
32 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.63784158 |
33 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.63306320 |
34 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.62366593 |
35 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.60404818 |
36 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.59633197 |
37 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.59421750 |
38 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.59252003 |
39 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.59084018 |
40 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.56606467 |
41 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.54919764 |
42 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.54166984 |
43 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.51248122 |
44 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.51186781 |
45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.50000921 |
46 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.48822055 |
47 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48661875 |
48 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.47850169 |
49 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.46632065 |
50 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.46451961 |
51 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.45841284 |
52 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.42066523 |
53 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.39590745 |
54 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.38310225 |
55 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.34997963 |
56 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.33877811 |
57 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.33862409 |
58 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.32785301 |
59 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.31831196 |
60 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.31683252 |
61 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.31027087 |
62 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.31027087 |
63 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.31023096 |
64 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.30942122 |
65 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.29774447 |
66 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.29658406 |
67 | FUS_26573619_Chip-Seq_HEK293_Human | 1.27622007 |
68 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.25270433 |
69 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.23573130 |
70 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.23181841 |
71 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.22583574 |
72 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.22212307 |
73 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.20797230 |
74 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.19659614 |
75 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.19438192 |
76 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.19229953 |
77 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.17672902 |
78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.17667177 |
79 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.17474805 |
80 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.17278394 |
81 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.17259976 |
82 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.17226720 |
83 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.17043853 |
84 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.16402710 |
85 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.16178149 |
86 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.15964638 |
87 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.15607406 |
88 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.14393240 |
89 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.13954881 |
90 | * BCL6_27268052_Chip-Seq_Bcells_Human | 1.11464782 |
91 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.11180226 |
92 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.10725828 |
93 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.09744241 |
94 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.09319098 |
95 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.07396601 |
96 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.06808906 |
97 | P300_19829295_ChIP-Seq_ESCs_Human | 1.06181655 |
98 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.05864642 |
99 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.04700995 |
100 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.04494386 |
101 | P68_20966046_ChIP-Seq_HELA_Human | 1.04386945 |
102 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.02268393 |
103 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.01805567 |
104 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.01241283 |
105 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.01055380 |
106 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.00799544 |
107 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.00685097 |
108 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.99646989 |
109 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.99114493 |
110 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.98661213 |
111 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.98298203 |
112 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.97887443 |
113 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.97659844 |
114 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.96674578 |
115 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.95118208 |
116 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.93888974 |
117 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.93175811 |
118 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.92971022 |
119 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.92902354 |
120 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.91450120 |
121 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.91311830 |
122 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.91266424 |
123 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.91037555 |
124 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.90966627 |
125 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.90478216 |
126 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.90428591 |
127 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.90109958 |
128 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.89381551 |
129 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.88623998 |
130 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.88590517 |
131 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.87428207 |
132 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.87423068 |
133 | * BCOR_27268052_Chip-Seq_Bcells_Human | 0.86744293 |
134 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.86287252 |
135 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.86089369 |
136 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.85904225 |
137 | SA1_27219007_Chip-Seq_Bcells_Human | 0.85250346 |
138 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.84533077 |
139 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.83527417 |
140 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.82919873 |
141 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.82734904 |
142 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.82496468 |
143 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.82046028 |
144 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.81739591 |
145 | * XRN2_22483619_ChIP-Seq_HELA_Human | 0.81185548 |
146 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 0.81159000 |
147 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.80950358 |
148 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.80882216 |
149 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.80048950 |
150 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.79912469 |
151 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.79585624 |
152 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.79321679 |
153 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.79162259 |
154 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.79078113 |
155 | JUN_21703547_ChIP-Seq_K562_Human | 0.78548242 |
156 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.77880223 |
157 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.77106730 |
158 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.75871607 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002837_dystrophic_cardiac_calcinosis | 4.92608957 |
2 | MP0003880_abnormal_central_pattern | 4.26022221 |
3 | MP0003806_abnormal_nucleotide_metabolis | 3.62872558 |
4 | MP0001529_abnormal_vocalization | 3.42374958 |
5 | MP0003186_abnormal_redox_activity | 3.35904210 |
6 | MP0009379_abnormal_foot_pigmentation | 3.13793621 |
7 | MP0006276_abnormal_autonomic_nervous | 2.92832998 |
8 | MP0003646_muscle_fatigue | 2.91975890 |
9 | MP0006292_abnormal_olfactory_placode | 2.89168510 |
10 | MP0000751_myopathy | 2.83831512 |
11 | MP0004215_abnormal_myocardial_fiber | 2.59661696 |
12 | MP0001905_abnormal_dopamine_level | 2.49290522 |
13 | MP0010030_abnormal_orbit_morphology | 2.46502195 |
14 | MP0006036_abnormal_mitochondrial_physio | 2.26364992 |
15 | MP0004084_abnormal_cardiac_muscle | 2.20846027 |
16 | MP0004036_abnormal_muscle_relaxation | 2.20733265 |
17 | MP0001968_abnormal_touch/_nociception | 2.19796894 |
18 | MP0002938_white_spotting | 2.16598328 |
19 | MP0002736_abnormal_nociception_after | 2.16346894 |
20 | MP0000749_muscle_degeneration | 2.15906140 |
21 | MP0003786_premature_aging | 2.06538412 |
22 | MP0003136_yellow_coat_color | 2.03373881 |
23 | MP0002653_abnormal_ependyma_morphology | 2.02001547 |
24 | MP0008058_abnormal_DNA_repair | 1.99968939 |
25 | MP0009046_muscle_twitch | 1.96067609 |
26 | MP0003693_abnormal_embryo_hatching | 1.94516132 |
27 | MP0004142_abnormal_muscle_tone | 1.94197158 |
28 | MP0003137_abnormal_impulse_conducting | 1.92363349 |
29 | MP0002272_abnormal_nervous_system | 1.92009053 |
30 | MP0009745_abnormal_behavioral_response | 1.91701807 |
31 | MP0006035_abnormal_mitochondrial_morpho | 1.89644074 |
32 | MP0002064_seizures | 1.87851595 |
33 | MP0003011_delayed_dark_adaptation | 1.86581547 |
34 | MP0005330_cardiomyopathy | 1.79152823 |
35 | MP0001440_abnormal_grooming_behavior | 1.77167009 |
36 | MP0003635_abnormal_synaptic_transmissio | 1.76908059 |
37 | MP0002735_abnormal_chemical_nociception | 1.76213364 |
38 | MP0004145_abnormal_muscle_electrophysio | 1.71386259 |
39 | MP0002822_catalepsy | 1.68186321 |
40 | MP0002734_abnormal_mechanical_nocicepti | 1.63652763 |
41 | MP0002572_abnormal_emotion/affect_behav | 1.56958945 |
42 | MP0008875_abnormal_xenobiotic_pharmacok | 1.54260947 |
43 | MP0008995_early_reproductive_senescence | 1.52399188 |
44 | MP0001188_hyperpigmentation | 1.52186398 |
45 | MP0005084_abnormal_gallbladder_morpholo | 1.50445840 |
46 | MP0002972_abnormal_cardiac_muscle | 1.49420472 |
47 | MP0003123_paternal_imprinting | 1.48749937 |
48 | MP0001970_abnormal_pain_threshold | 1.43696266 |
49 | MP0004085_abnormal_heartbeat | 1.43005523 |
50 | MP0002332_abnormal_exercise_endurance | 1.42792187 |
51 | MP0008932_abnormal_embryonic_tissue | 1.40876930 |
52 | MP0001764_abnormal_homeostasis | 1.40129956 |
53 | MP0004924_abnormal_behavior | 1.39915156 |
54 | MP0005386_behavior/neurological_phenoty | 1.39915156 |
55 | MP0002638_abnormal_pupillary_reflex | 1.39226358 |
56 | MP0002067_abnormal_sensory_capabilities | 1.37539897 |
57 | MP0002163_abnormal_gland_morphology | 1.34436945 |
58 | MP0003122_maternal_imprinting | 1.33980225 |
59 | MP0001486_abnormal_startle_reflex | 1.33712597 |
60 | MP0010386_abnormal_urinary_bladder | 1.32637440 |
61 | MP0002063_abnormal_learning/memory/cond | 1.32560582 |
62 | MP0005620_abnormal_muscle_contractility | 1.31756508 |
63 | MP0004484_altered_response_of | 1.30944845 |
64 | MP0004957_abnormal_blastocyst_morpholog | 1.30697500 |
65 | MP0004270_analgesia | 1.30167687 |
66 | MP0000049_abnormal_middle_ear | 1.29516219 |
67 | MP0005670_abnormal_white_adipose | 1.28022541 |
68 | MP0001501_abnormal_sleep_pattern | 1.27956024 |
69 | MP0002733_abnormal_thermal_nociception | 1.27881866 |
70 | MP0005409_darkened_coat_color | 1.25726503 |
71 | MP0004859_abnormal_synaptic_plasticity | 1.24168479 |
72 | MP0003718_maternal_effect | 1.22323534 |
73 | MP0000750_abnormal_muscle_regeneration | 1.18971583 |
74 | MP0005499_abnormal_olfactory_system | 1.18170494 |
75 | MP0005394_taste/olfaction_phenotype | 1.18170494 |
76 | MP0002876_abnormal_thyroid_physiology | 1.16908650 |
77 | MP0002106_abnormal_muscle_physiology | 1.16319099 |
78 | MP0004043_abnormal_pH_regulation | 1.15374002 |
79 | MP0005332_abnormal_amino_acid | 1.15052811 |
80 | MP0001293_anophthalmia | 1.14870755 |
81 | MP0005379_endocrine/exocrine_gland_phen | 1.14346549 |
82 | MP0005423_abnormal_somatic_nervous | 1.13852137 |
83 | MP0002184_abnormal_innervation | 1.12461234 |
84 | MP0006072_abnormal_retinal_apoptosis | 1.12154717 |
85 | MP0005377_hearing/vestibular/ear_phenot | 1.11595078 |
86 | MP0003878_abnormal_ear_physiology | 1.11595078 |
87 | MP0000358_abnormal_cell_content/ | 1.11032631 |
88 | MP0001984_abnormal_olfaction | 1.10031827 |
89 | MP0002234_abnormal_pharynx_morphology | 1.09507144 |
90 | MP0001986_abnormal_taste_sensitivity | 1.07834318 |
91 | MP0000013_abnormal_adipose_tissue | 1.06386363 |
92 | MP0005075_abnormal_melanosome_morpholog | 1.06130526 |
93 | MP0005171_absent_coat_pigmentation | 1.05669988 |
94 | MP0003077_abnormal_cell_cycle | 1.04964389 |
95 | MP0002095_abnormal_skin_pigmentation | 1.03166044 |
96 | MP0002127_abnormal_cardiovascular_syste | 1.02579913 |
97 | MP0005369_muscle_phenotype | 1.02521060 |
98 | MP0008775_abnormal_heart_ventricle | 1.01188486 |
99 | MP0005385_cardiovascular_system_phenoty | 1.01122939 |
100 | MP0001544_abnormal_cardiovascular_syste | 1.01122939 |
101 | MP0000372_irregular_coat_pigmentation | 1.00433475 |
102 | MP0001485_abnormal_pinna_reflex | 0.99887523 |
103 | MP0006138_congestive_heart_failure | 0.99815437 |
104 | MP0002557_abnormal_social/conspecific_i | 0.99798874 |
105 | MP0003111_abnormal_nucleus_morphology | 0.99264108 |
106 | MP0001727_abnormal_embryo_implantation | 0.99237289 |
107 | MP0002282_abnormal_trachea_morphology | 0.98911897 |
108 | MP0000778_abnormal_nervous_system | 0.98317535 |
109 | MP0005408_hypopigmentation | 0.97938473 |
110 | MP0002160_abnormal_reproductive_system | 0.97706395 |
111 | MP0002102_abnormal_ear_morphology | 0.94912097 |
112 | MP0005174_abnormal_tail_pigmentation | 0.94448992 |
113 | MP0000747_muscle_weakness | 0.90726165 |
114 | MP0008007_abnormal_cellular_replicative | 0.90528783 |
115 | MP0004133_heterotaxia | 0.90057394 |
116 | MP0005645_abnormal_hypothalamus_physiol | 0.89690511 |
117 | MP0010094_abnormal_chromosome_stability | 0.89223672 |
118 | MP0003938_abnormal_ear_development | 0.87852796 |
119 | MP0004742_abnormal_vestibular_system | 0.87501932 |
120 | MP0002066_abnormal_motor_capabilities/c | 0.87284515 |
121 | MP0001664_abnormal_digestion | 0.87027688 |
122 | MP0004087_abnormal_muscle_fiber | 0.85096031 |
123 | MP0005266_abnormal_metabolism | 0.85012016 |
124 | MP0005410_abnormal_fertilization | 0.84088251 |
125 | MP0000230_abnormal_systemic_arterial | 0.83921686 |
126 | MP0000759_abnormal_skeletal_muscle | 0.83157246 |
127 | MP0005551_abnormal_eye_electrophysiolog | 0.83043401 |
128 | MP0005253_abnormal_eye_physiology | 0.81424714 |
129 | MP0001756_abnormal_urination | 0.80509929 |
130 | MP0001963_abnormal_hearing_physiology | 0.80228429 |
131 | MP0000026_abnormal_inner_ear | 0.79896230 |
132 | MP0002751_abnormal_autonomic_nervous | 0.78289498 |
133 | MP0001919_abnormal_reproductive_system | 0.78266513 |
134 | MP0002752_abnormal_somatic_nervous | 0.77807279 |
135 | MP0002229_neurodegeneration | 0.77473035 |
136 | MP0009333_abnormal_splenocyte_physiolog | 0.77242282 |
137 | MP0005636_abnormal_mineral_homeostasis | 0.77182775 |
138 | MP0005535_abnormal_body_temperature | 0.76938180 |
139 | MP0003315_abnormal_perineum_morphology | 0.76861505 |
140 | MP0001346_abnormal_lacrimal_gland | 0.76580559 |
141 | MP0000631_abnormal_neuroendocrine_gland | 0.76444366 |
142 | MP0002132_abnormal_respiratory_system | 0.76422287 |
143 | MP0000538_abnormal_urinary_bladder | 0.75343153 |
144 | MP0005389_reproductive_system_phenotype | 0.75292277 |
145 | MP0002210_abnormal_sex_determination | 0.75287243 |
146 | MP0002882_abnormal_neuron_morphology | 0.74206481 |
147 | MP0004147_increased_porphyrin_level | 0.73078148 |
148 | MP0002277_abnormal_respiratory_mucosa | 0.72676591 |
149 | MP0008872_abnormal_physiological_respon | 0.71406302 |
150 | MP0003941_abnormal_skin_development | 0.71283242 |
151 | MP0003638_abnormal_response/metabolism_ | 0.70719456 |
152 | MP0005646_abnormal_pituitary_gland | 0.69546714 |
153 | MP0008789_abnormal_olfactory_epithelium | 0.69186557 |
154 | MP0003950_abnormal_plasma_membrane | 0.69078349 |
155 | MP0000566_synostosis | 0.64757259 |
156 | MP0000343_altered_response_to | 0.64565512 |
157 | MP0001324_abnormal_eye_pigmentation | 0.64084259 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Acute necrotizing encephalopathy (HP:0006965) | 7.65728207 |
2 | * Abnormal mitochondria in muscle tissue (HP:0008316) | 6.95248458 |
3 | * Mitochondrial inheritance (HP:0001427) | 6.72918729 |
4 | * Progressive macrocephaly (HP:0004481) | 6.36906838 |
5 | * Acute encephalopathy (HP:0006846) | 6.17580689 |
6 | Hepatocellular necrosis (HP:0001404) | 6.02648170 |
7 | * Increased CSF lactate (HP:0002490) | 5.73064096 |
8 | Hepatic necrosis (HP:0002605) | 5.33317074 |
9 | Increased hepatocellular lipid droplets (HP:0006565) | 4.92601134 |
10 | Reticulocytopenia (HP:0001896) | 4.82764007 |
11 | Lipid accumulation in hepatocytes (HP:0006561) | 4.52201041 |
12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.29473093 |
13 | * Cerebral edema (HP:0002181) | 4.28832818 |
14 | Renal Fanconi syndrome (HP:0001994) | 4.18404470 |
15 | * Respiratory failure (HP:0002878) | 4.04458042 |
16 | * Exercise intolerance (HP:0003546) | 4.01366261 |
17 | Increased intramyocellular lipid droplets (HP:0012240) | 3.97359741 |
18 | * Lactic acidosis (HP:0003128) | 3.91942038 |
19 | * Optic disc pallor (HP:0000543) | 3.90932731 |
20 | Increased serum pyruvate (HP:0003542) | 3.85303172 |
21 | Abnormality of glycolysis (HP:0004366) | 3.85303172 |
22 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.82155607 |
23 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.66450116 |
24 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.66450116 |
25 | Increased serum lactate (HP:0002151) | 3.55994408 |
26 | Increased muscle lipid content (HP:0009058) | 3.48292069 |
27 | * Leukodystrophy (HP:0002415) | 3.46557005 |
28 | 3-Methylglutaconic aciduria (HP:0003535) | 3.35468457 |
29 | Sudden death (HP:0001699) | 3.34607239 |
30 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.33883419 |
31 | Pheochromocytoma (HP:0002666) | 3.22101139 |
32 | Neuroendocrine neoplasm (HP:0100634) | 3.19670292 |
33 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.13822923 |
34 | Exertional dyspnea (HP:0002875) | 3.13349879 |
35 | Calf muscle hypertrophy (HP:0008981) | 3.03767808 |
36 | Pallor (HP:0000980) | 3.03573471 |
37 | Testicular atrophy (HP:0000029) | 3.02904582 |
38 | Respiratory difficulties (HP:0002880) | 2.85115629 |
39 | Type I transferrin isoform profile (HP:0003642) | 2.78487886 |
40 | Abnormality of renal resorption (HP:0011038) | 2.77921013 |
41 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.76509630 |
42 | Focal motor seizures (HP:0011153) | 2.69675500 |
43 | CNS demyelination (HP:0007305) | 2.61080541 |
44 | Palpitations (HP:0001962) | 2.59989816 |
45 | Generalized aminoaciduria (HP:0002909) | 2.58951494 |
46 | Emotional lability (HP:0000712) | 2.58325296 |
47 | * X-linked dominant inheritance (HP:0001423) | 2.54070954 |
48 | Myokymia (HP:0002411) | 2.46989325 |
49 | Parakeratosis (HP:0001036) | 2.46010567 |
50 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.45146365 |
51 | Dicarboxylic aciduria (HP:0003215) | 2.34726590 |
52 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.34726590 |
53 | Hyperphosphaturia (HP:0003109) | 2.33310120 |
54 | Congenital, generalized hypertrichosis (HP:0004540) | 2.25888199 |
55 | Abnormality of the calf musculature (HP:0001430) | 2.25390817 |
56 | Aplastic anemia (HP:0001915) | 2.21882393 |
57 | Abnormality of urine glucose concentration (HP:0011016) | 2.20775351 |
58 | Glycosuria (HP:0003076) | 2.20775351 |
59 | Ventricular tachycardia (HP:0004756) | 2.18600127 |
60 | * Lethargy (HP:0001254) | 2.17543760 |
61 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.15151566 |
62 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.15151566 |
63 | Abnormal protein glycosylation (HP:0012346) | 2.15151566 |
64 | Abnormal glycosylation (HP:0012345) | 2.15151566 |
65 | Syncope (HP:0001279) | 2.14210821 |
66 | Myotonia (HP:0002486) | 2.12524903 |
67 | Atonic seizures (HP:0010819) | 2.12262792 |
68 | Amniotic constriction ring (HP:0009775) | 2.07751772 |
69 | Abnormality of placental membranes (HP:0011409) | 2.07751772 |
70 | Abnormal number of erythroid precursors (HP:0012131) | 2.07545804 |
71 | Progressive external ophthalmoplegia (HP:0000590) | 2.06663433 |
72 | Conjunctival hamartoma (HP:0100780) | 2.05902341 |
73 | Prolonged QT interval (HP:0001657) | 2.01974022 |
74 | Pancytopenia (HP:0001876) | 2.00782111 |
75 | Atrial fibrillation (HP:0005110) | 2.00049479 |
76 | Abnormal pupillary function (HP:0007686) | 1.96256373 |
77 | Supraventricular tachycardia (HP:0004755) | 1.95970224 |
78 | Exercise-induced myalgia (HP:0003738) | 1.95120814 |
79 | Hyperglycinemia (HP:0002154) | 1.94034122 |
80 | Rib fusion (HP:0000902) | 1.92751817 |
81 | Primary atrial arrhythmia (HP:0001692) | 1.92306304 |
82 | Absent thumb (HP:0009777) | 1.92258012 |
83 | Microvesicular hepatic steatosis (HP:0001414) | 1.92252262 |
84 | Abnormal urine phosphate concentration (HP:0012599) | 1.91580079 |
85 | Microretrognathia (HP:0000308) | 1.91528100 |
86 | Pancreatic fibrosis (HP:0100732) | 1.91315825 |
87 | Hypoplastic left heart (HP:0004383) | 1.89390232 |
88 | Macrocytic anemia (HP:0001972) | 1.89007679 |
89 | Muscle fiber splitting (HP:0003555) | 1.88991433 |
90 | Supraventricular arrhythmia (HP:0005115) | 1.87546347 |
91 | Limb dystonia (HP:0002451) | 1.86460545 |
92 | Colon cancer (HP:0003003) | 1.86179805 |
93 | Hypothermia (HP:0002045) | 1.85192789 |
94 | Opisthotonus (HP:0002179) | 1.84854532 |
95 | Sclerocornea (HP:0000647) | 1.84363153 |
96 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.82962871 |
97 | Lipoatrophy (HP:0100578) | 1.82612369 |
98 | Cerebral hemorrhage (HP:0001342) | 1.81848343 |
99 | Abnormality of midbrain morphology (HP:0002418) | 1.81251898 |
100 | Molar tooth sign on MRI (HP:0002419) | 1.81251898 |
101 | Pancreatic cysts (HP:0001737) | 1.80986709 |
102 | Progressive microcephaly (HP:0000253) | 1.80859375 |
103 | Cerebral hypomyelination (HP:0006808) | 1.79163547 |
104 | Medial flaring of the eyebrow (HP:0010747) | 1.78724010 |
105 | Muscle fiber atrophy (HP:0100295) | 1.77889559 |
106 | Rough bone trabeculation (HP:0100670) | 1.77634163 |
107 | Gliosis (HP:0002171) | 1.77068060 |
108 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.76484263 |
109 | Septo-optic dysplasia (HP:0100842) | 1.74777907 |
110 | Partial duplication of thumb phalanx (HP:0009944) | 1.74709816 |
111 | Poor suck (HP:0002033) | 1.74088582 |
112 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.74010968 |
113 | Abnormality of alanine metabolism (HP:0010916) | 1.74010968 |
114 | Hyperalaninemia (HP:0003348) | 1.74010968 |
115 | Congenital malformation of the right heart (HP:0011723) | 1.72993840 |
116 | Double outlet right ventricle (HP:0001719) | 1.72993840 |
117 | Methylmalonic aciduria (HP:0012120) | 1.72307593 |
118 | Renal tubular dysfunction (HP:0000124) | 1.71922914 |
119 | Oral leukoplakia (HP:0002745) | 1.70931271 |
120 | Left ventricular hypertrophy (HP:0001712) | 1.69439049 |
121 | Hyperventilation (HP:0002883) | 1.69127560 |
122 | Ragged-red muscle fibers (HP:0003200) | 1.68989384 |
123 | Progressive muscle weakness (HP:0003323) | 1.68481115 |
124 | * Vomiting (HP:0002013) | 1.67140431 |
125 | Cleft eyelid (HP:0000625) | 1.66341292 |
126 | Reduced antithrombin III activity (HP:0001976) | 1.66141708 |
127 | Abnormality of the vocal cords (HP:0008777) | 1.65305932 |
128 | Neoplasm of head and neck (HP:0012288) | 1.64259565 |
129 | Esophageal neoplasm (HP:0100751) | 1.64259565 |
130 | * Blindness (HP:0000618) | 1.63096256 |
131 | Anxiety (HP:0000739) | 1.62406796 |
132 | Exercise-induced muscle cramps (HP:0003710) | 1.62376044 |
133 | Absence seizures (HP:0002121) | 1.62210979 |
134 | Severe visual impairment (HP:0001141) | 1.61515015 |
135 | Partial duplication of the phalanx of hand (HP:0009999) | 1.61443741 |
136 | Degeneration of anterior horn cells (HP:0002398) | 1.60611446 |
137 | Abnormality of the anterior horn cell (HP:0006802) | 1.60611446 |
138 | Gait imbalance (HP:0002141) | 1.60564225 |
139 | True hermaphroditism (HP:0010459) | 1.60311553 |
140 | Methylmalonic acidemia (HP:0002912) | 1.60227346 |
141 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.60051321 |
142 | Muscle stiffness (HP:0003552) | 1.59237904 |
143 | Type 2 muscle fiber atrophy (HP:0003554) | 1.59028639 |
144 | Hypoplastic heart (HP:0001961) | 1.58881450 |
145 | Unsteady gait (HP:0002317) | 1.58640693 |
146 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.58061915 |
147 | Retinal dysplasia (HP:0007973) | 1.57859941 |
148 | Maternal diabetes (HP:0009800) | 1.57680399 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 6.58398245 |
2 | NME1 | 3.75762934 |
3 | MAP3K12 | 3.41984546 |
4 | MYLK | 3.23749275 |
5 | CASK | 3.10474138 |
6 | STK16 | 2.44832779 |
7 | NME2 | 2.39157775 |
8 | TESK2 | 2.37618313 |
9 | GRK7 | 2.29080189 |
10 | ARAF | 2.23026073 |
11 | OBSCN | 2.22610587 |
12 | TLK1 | 2.12745013 |
13 | STK39 | 2.05054229 |
14 | CDK19 | 2.03568669 |
15 | PNCK | 2.01211797 |
16 | MST4 | 2.00267240 |
17 | MAP2K7 | 1.90372952 |
18 | TESK1 | 1.87840235 |
19 | GRK5 | 1.86577346 |
20 | CDC7 | 1.86055889 |
21 | MUSK | 1.83762198 |
22 | LIMK1 | 1.79068108 |
23 | KDR | 1.78111168 |
24 | WNK4 | 1.66398257 |
25 | MAP4K2 | 1.57721469 |
26 | OXSR1 | 1.52397955 |
27 | PHKG2 | 1.49307674 |
28 | PHKG1 | 1.49307674 |
29 | BRAF | 1.49297291 |
30 | BCR | 1.47021344 |
31 | MAP3K4 | 1.40834166 |
32 | INSRR | 1.39581970 |
33 | PDK4 | 1.38691489 |
34 | PDK3 | 1.38691489 |
35 | CAMK2D | 1.34149614 |
36 | BCKDK | 1.26616056 |
37 | LRRK2 | 1.26542717 |
38 | BUB1 | 1.26540474 |
39 | BMPR1B | 1.25876955 |
40 | ADRBK2 | 1.23254917 |
41 | LMTK2 | 1.18883181 |
42 | CAMK2A | 1.15744513 |
43 | VRK1 | 1.15642657 |
44 | PBK | 1.15538139 |
45 | MARK1 | 1.13767689 |
46 | NTRK3 | 1.13693834 |
47 | TNIK | 1.12957424 |
48 | CAMK2B | 1.12417124 |
49 | DAPK3 | 1.11272073 |
50 | NUAK1 | 1.09606561 |
51 | TAF1 | 1.08755298 |
52 | PLK2 | 1.07868911 |
53 | EPHA4 | 1.07576008 |
54 | BRSK1 | 1.06412315 |
55 | EIF2AK1 | 1.05094691 |
56 | BMPR2 | 1.01758243 |
57 | MAPK13 | 1.00801594 |
58 | MINK1 | 0.98068477 |
59 | DYRK3 | 0.97698460 |
60 | ADRBK1 | 0.94988797 |
61 | NEK1 | 0.94728000 |
62 | CAMK2G | 0.94178160 |
63 | UHMK1 | 0.93841579 |
64 | PINK1 | 0.93117141 |
65 | RPS6KA5 | 0.91208666 |
66 | PRKCE | 0.90247471 |
67 | DYRK2 | 0.89947642 |
68 | WNK3 | 0.89559946 |
69 | PDK2 | 0.87321050 |
70 | PKN1 | 0.87054158 |
71 | ROCK2 | 0.86695134 |
72 | STK24 | 0.86496300 |
73 | PIM2 | 0.85929582 |
74 | MAP2K4 | 0.85925765 |
75 | MAPKAPK5 | 0.83155634 |
76 | PIK3CA | 0.82710348 |
77 | AURKB | 0.81526087 |
78 | ILK | 0.81249207 |
79 | SRPK1 | 0.74952709 |
80 | CHEK2 | 0.74091138 |
81 | CCNB1 | 0.72576778 |
82 | GRK1 | 0.72486377 |
83 | PLK1 | 0.71933641 |
84 | ABL2 | 0.70708653 |
85 | PRKCG | 0.70026014 |
86 | PAK1 | 0.69998338 |
87 | PRKACA | 0.68240562 |
88 | CSNK1G3 | 0.67818747 |
89 | CDK8 | 0.66777321 |
90 | ZAK | 0.64674776 |
91 | TSSK6 | 0.62483660 |
92 | STK4 | 0.61314774 |
93 | WEE1 | 0.60243109 |
94 | CSNK1G2 | 0.58671025 |
95 | PLK3 | 0.58001677 |
96 | STK38L | 0.57649314 |
97 | EIF2AK3 | 0.57390165 |
98 | PLK4 | 0.56505483 |
99 | CDK14 | 0.55168371 |
100 | TAOK2 | 0.53709281 |
101 | AKT3 | 0.53443791 |
102 | CSNK1G1 | 0.53286483 |
103 | MAPKAPK3 | 0.52981341 |
104 | FGR | 0.52470763 |
105 | CDC42BPA | 0.50484732 |
106 | ATR | 0.49202257 |
107 | ROCK1 | 0.48574648 |
108 | PAK3 | 0.48290322 |
109 | PTK2B | 0.47384580 |
110 | CDK18 | 0.47276449 |
111 | AURKA | 0.47128950 |
112 | FES | 0.46551940 |
113 | CDK11A | 0.46512140 |
114 | EPHB2 | 0.46087382 |
115 | MAPK15 | 0.45033548 |
116 | NTRK2 | 0.44959173 |
117 | CDK5 | 0.44228727 |
118 | CDK15 | 0.43569777 |
119 | CSNK1A1L | 0.43204886 |
120 | PRKCI | 0.43019822 |
121 | DAPK1 | 0.41700343 |
122 | TTN | 0.41633364 |
123 | CDK7 | 0.39020840 |
124 | SCYL2 | 0.38948923 |
125 | IRAK2 | 0.38564417 |
126 | PRPF4B | 0.37742830 |
127 | IRAK3 | 0.35891547 |
128 | CSNK2A1 | 0.34976873 |
129 | WNK1 | 0.34755117 |
130 | GRK6 | 0.33706142 |
131 | IKBKB | 0.33109445 |
132 | PAK4 | 0.32904244 |
133 | MAPK12 | 0.32741157 |
134 | MAP3K11 | 0.32489709 |
135 | AKT2 | 0.32377211 |
136 | TIE1 | 0.32146289 |
137 | CSNK2A2 | 0.31434840 |
138 | BMX | 0.25705652 |
139 | CSNK1A1 | 0.25027627 |
140 | BRSK2 | 0.24113016 |
141 | PASK | 0.21496581 |
142 | CAMK1 | 0.20820600 |
143 | PRKCD | 0.18727422 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Oxidative phosphorylation_Homo sapiens_hsa00190 | 6.88308082 |
2 | Parkinsons disease_Homo sapiens_hsa05012 | 5.88135130 |
3 | Alzheimers disease_Homo sapiens_hsa05010 | 4.48327264 |
4 | Huntingtons disease_Homo sapiens_hsa05016 | 4.12974402 |
5 | * Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 3.61703076 |
6 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.57054416 |
7 | Ribosome_Homo sapiens_hsa03010 | 3.38625473 |
8 | Proteasome_Homo sapiens_hsa03050 | 2.95361014 |
9 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.52421964 |
10 | DNA replication_Homo sapiens_hsa03030 | 2.49209158 |
11 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.23377281 |
12 | Protein export_Homo sapiens_hsa03060 | 2.21285359 |
13 | Mismatch repair_Homo sapiens_hsa03430 | 2.11751449 |
14 | RNA polymerase_Homo sapiens_hsa03020 | 1.95537126 |
15 | Base excision repair_Homo sapiens_hsa03410 | 1.85757057 |
16 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.63657511 |
17 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.59664899 |
18 | Nicotine addiction_Homo sapiens_hsa05033 | 1.50246589 |
19 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.43918571 |
20 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.42960149 |
21 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.39821229 |
22 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.34116447 |
23 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.31117138 |
24 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.27391720 |
25 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.22172364 |
26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.10076397 |
27 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.09838151 |
28 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.09102191 |
29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.08259884 |
30 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.08201420 |
31 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.97767291 |
32 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.96917123 |
33 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.96590486 |
34 | Taste transduction_Homo sapiens_hsa04742 | 0.93333985 |
35 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.88434369 |
36 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.86028755 |
37 | Carbon metabolism_Homo sapiens_hsa01200 | 0.84893224 |
38 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.84456692 |
39 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.81260703 |
40 | GABAergic synapse_Homo sapiens_hsa04727 | 0.80972345 |
41 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.74807685 |
42 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.74410003 |
43 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.73021859 |
44 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.72859533 |
45 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.70874965 |
46 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.70389086 |
47 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.70317366 |
48 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.69235452 |
49 | RNA transport_Homo sapiens_hsa03013 | 0.68338329 |
50 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.66445081 |
51 | Phototransduction_Homo sapiens_hsa04744 | 0.62370582 |
52 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.62282099 |
53 | Morphine addiction_Homo sapiens_hsa05032 | 0.59815991 |
54 | Purine metabolism_Homo sapiens_hsa00230 | 0.59292313 |
55 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.58588691 |
56 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.58012895 |
57 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.55416332 |
58 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54659548 |
59 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.54087670 |
60 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.53975521 |
61 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.53400096 |
62 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.52041564 |
63 | Circadian entrainment_Homo sapiens_hsa04713 | 0.50961336 |
64 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.49586995 |
65 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.48986040 |
66 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.48396616 |
67 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.48377422 |
68 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.48187096 |
69 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.47961198 |
70 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.46613519 |
71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.45883559 |
72 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.45453805 |
73 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.44926303 |
74 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.44374565 |
75 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.44006779 |
76 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.42424268 |
77 | Sulfur relay system_Homo sapiens_hsa04122 | 0.41678571 |
78 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.41095016 |
79 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.40076656 |
80 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.39337172 |
81 | Long-term depression_Homo sapiens_hsa04730 | 0.38694008 |
82 | Long-term potentiation_Homo sapiens_hsa04720 | 0.38187348 |
83 | Olfactory transduction_Homo sapiens_hsa04740 | 0.37442603 |
84 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.36253089 |
85 | Insulin secretion_Homo sapiens_hsa04911 | 0.36039087 |
86 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.35895610 |
87 | Basal transcription factors_Homo sapiens_hsa03022 | 0.34809583 |
88 | Cocaine addiction_Homo sapiens_hsa05030 | 0.34606650 |
89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.33951713 |
90 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.33907452 |
91 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.33606861 |
92 | Renin secretion_Homo sapiens_hsa04924 | 0.32990075 |
93 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.32382330 |
94 | Phagosome_Homo sapiens_hsa04145 | 0.31123467 |
95 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.29777056 |
96 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.29274251 |
97 | Cell cycle_Homo sapiens_hsa04110 | 0.28354918 |
98 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.28303793 |
99 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.27977160 |
100 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.27518769 |
101 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.27454361 |
102 | Salivary secretion_Homo sapiens_hsa04970 | 0.27000970 |
103 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.26255536 |
104 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.25679261 |
105 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.25525212 |
106 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.25221412 |
107 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.24842989 |
108 | Peroxisome_Homo sapiens_hsa04146 | 0.23569364 |
109 | Spliceosome_Homo sapiens_hsa03040 | 0.23459080 |
110 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.23037337 |
111 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.22390219 |
112 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.22266831 |
113 | Alcoholism_Homo sapiens_hsa05034 | 0.21847184 |
114 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.21768809 |
115 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.20993876 |
116 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.19810929 |
117 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.19055717 |
118 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.18969203 |
119 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.18708882 |
120 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.18457513 |
121 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.18414542 |
122 | Galactose metabolism_Homo sapiens_hsa00052 | 0.17636794 |
123 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.17530980 |
124 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.17428442 |
125 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.17279705 |
126 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.16800688 |
127 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.16060098 |
128 | Homologous recombination_Homo sapiens_hsa03440 | 0.15879697 |
129 | Gap junction_Homo sapiens_hsa04540 | 0.15507566 |
130 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.13633375 |
131 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.13618554 |
132 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.12554226 |
133 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.11940514 |
134 | RNA degradation_Homo sapiens_hsa03018 | 0.11154680 |
135 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.11091903 |