NDUFA12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is part of mitochondrial complex 1, part of the oxidative phosphorylation system in mitochondria. Complex 1 transfers electrons to ubiquinone from NADH which establishes a proton gradient for the generation of ATP. Mutations in this gene are associated with Leigh syndrome due to mitochondrial complex 1 deficiency. Pseudogenes of this gene are located on chromosomes 5 and 13. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.54006718
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.54006718
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.19148387
4* respiratory electron transport chain (GO:0022904)8.11558496
5* electron transport chain (GO:0022900)7.91080322
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.41264668
7protein complex biogenesis (GO:0070271)5.27922390
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.20103526
9mitochondrial respiratory chain complex I assembly (GO:0032981)5.20103526
10NADH dehydrogenase complex assembly (GO:0010257)5.20103526
11ATP biosynthetic process (GO:0006754)5.18714909
12chaperone-mediated protein transport (GO:0072321)5.17576950
13purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.97639065
14hydrogen ion transmembrane transport (GO:1902600)4.95123938
15ribosomal small subunit assembly (GO:0000028)4.92062641
16purine nucleoside triphosphate biosynthetic process (GO:0009145)4.87448592
17mitochondrial respiratory chain complex assembly (GO:0033108)4.82883665
18inner mitochondrial membrane organization (GO:0007007)4.80914364
19protein neddylation (GO:0045116)4.62093460
20proton transport (GO:0015992)4.36447642
21ribonucleoside triphosphate biosynthetic process (GO:0009201)4.32755715
22hydrogen transport (GO:0006818)4.28359561
23GTP biosynthetic process (GO:0006183)4.23873611
24oxidative phosphorylation (GO:0006119)4.11862617
25maturation of SSU-rRNA (GO:0030490)4.08311923
26ribosomal large subunit biogenesis (GO:0042273)3.97049118
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.96912850
28dopamine transport (GO:0015872)3.88523179
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.86130060
30viral life cycle (GO:0019058)3.83044438
31translational initiation (GO:0006413)3.82890433
32regulation of mitochondrial translation (GO:0070129)3.81094105
33cullin deneddylation (GO:0010388)3.76197995
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.75125001
35DNA damage response, detection of DNA damage (GO:0042769)3.73347817
36ribosomal small subunit biogenesis (GO:0042274)3.71916235
37nucleoside triphosphate biosynthetic process (GO:0009142)3.70921730
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68307376
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.65401412
40regulation of oxidative phosphorylation (GO:0002082)3.62047067
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61563867
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57508825
43negative regulation of ligase activity (GO:0051352)3.57508825
44sequestering of actin monomers (GO:0042989)3.57270214
45regulation of cellular amino acid metabolic process (GO:0006521)3.56505849
46protein deneddylation (GO:0000338)3.53969147
47ATP hydrolysis coupled proton transport (GO:0015991)3.52651308
48energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.52651308
49neuron cell-cell adhesion (GO:0007158)3.52028876
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.50969474
51UTP biosynthetic process (GO:0006228)3.48113071
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45015477
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45015477
54signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.42891823
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.42891823
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.42891823
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40346862
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40346862
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39822256
60chromatin remodeling at centromere (GO:0031055)3.32019020
61viral transcription (GO:0019083)3.31705781
62CENP-A containing nucleosome assembly (GO:0034080)3.28506653
63substantia nigra development (GO:0021762)3.26367478
64signal transduction involved in DNA integrity checkpoint (GO:0072401)3.26306680
65signal transduction involved in DNA damage checkpoint (GO:0072422)3.26306680
66respiratory chain complex IV assembly (GO:0008535)3.25723384
67cellular component biogenesis (GO:0044085)3.25312376
68protein targeting to mitochondrion (GO:0006626)3.23768010
69establishment of protein localization to mitochondrion (GO:0072655)3.23767188
70signal transduction involved in cell cycle checkpoint (GO:0072395)3.23706797
71protein complex disassembly (GO:0043241)3.22819079
72tricarboxylic acid cycle (GO:0006099)3.21015917
73mitochondrial transport (GO:0006839)3.20749493
74aerobic respiration (GO:0009060)3.19790610
75translational termination (GO:0006415)3.17477487
76spliceosomal snRNP assembly (GO:0000387)3.17063295
77DNA deamination (GO:0045006)3.16538662
78positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.15173583
79axon ensheathment in central nervous system (GO:0032291)3.15167942
80central nervous system myelination (GO:0022010)3.15167942
81proteasome assembly (GO:0043248)3.14848117
82protein targeting to membrane (GO:0006612)3.14794027
83macromolecular complex disassembly (GO:0032984)3.14251571
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13655092
85rRNA modification (GO:0000154)3.12730432
86regulation of cellular respiration (GO:0043457)3.12582703
87dopamine biosynthetic process (GO:0042416)3.12221305
88platelet dense granule organization (GO:0060155)3.11221943
89peptidyl-histidine modification (GO:0018202)3.09443617
90regulation of cell communication by electrical coupling (GO:0010649)3.07928443
91cotranslational protein targeting to membrane (GO:0006613)3.06763931
92protein localization to mitochondrion (GO:0070585)3.05740002
93regulation of catecholamine metabolic process (GO:0042069)3.03457282
94regulation of dopamine metabolic process (GO:0042053)3.03457282
95UTP metabolic process (GO:0046051)3.02313934
96negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.00917490
97cytochrome complex assembly (GO:0017004)3.00622906
98water-soluble vitamin biosynthetic process (GO:0042364)3.00401054
99guanosine-containing compound biosynthetic process (GO:1901070)2.99248295
100positive regulation of ligase activity (GO:0051351)2.98659881
101establishment of integrated proviral latency (GO:0075713)2.98642557
102protein targeting to ER (GO:0045047)2.96613536
103histone mRNA metabolic process (GO:0008334)2.96602631
104quinone biosynthetic process (GO:1901663)2.96216881
105ubiquinone biosynthetic process (GO:0006744)2.96216881
106pseudouridine synthesis (GO:0001522)2.94536507
107nuclear-transcribed mRNA catabolic process (GO:0000956)2.92441749
108SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91858075
109regulation of acyl-CoA biosynthetic process (GO:0050812)2.91741464
110nucleoside diphosphate phosphorylation (GO:0006165)2.91694859
111* generation of precursor metabolites and energy (GO:0006091)2.91356560
112regulation of protein kinase A signaling (GO:0010738)2.87741456
113purine nucleoside monophosphate biosynthetic process (GO:0009127)2.87510738
114purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.87510738
115establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86794056
116protein localization to endoplasmic reticulum (GO:0070972)2.85611452
117response to epinephrine (GO:0071871)2.83835280
118ubiquinone metabolic process (GO:0006743)2.82628269
119intracellular protein transmembrane import (GO:0044743)2.81557433
120fatty acid elongation (GO:0030497)2.81188723
121NADH metabolic process (GO:0006734)2.81085781
122regulation of helicase activity (GO:0051095)2.78793765
123long-chain fatty acid biosynthetic process (GO:0042759)2.78166007
124CTP metabolic process (GO:0046036)2.78018304
125CTP biosynthetic process (GO:0006241)2.78018304
126calcium-mediated signaling using intracellular calcium source (GO:0035584)2.77862262
127cellular response to epinephrine stimulus (GO:0071872)2.77827377
128protein-cofactor linkage (GO:0018065)2.76029760
129succinate metabolic process (GO:0006105)2.75777463
130presynaptic membrane assembly (GO:0097105)2.75050163
131negative regulation of protein localization to cell surface (GO:2000009)2.64598702
132regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63913940
133presynaptic membrane organization (GO:0097090)2.63581086
134regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.63033914
135cellular protein complex disassembly (GO:0043624)2.62479003
136termination of RNA polymerase III transcription (GO:0006386)2.62248488
137transcription elongation from RNA polymerase III promoter (GO:0006385)2.62248488
138detection of calcium ion (GO:0005513)2.61611085
139regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.59963302
140regulation of cofactor metabolic process (GO:0051193)2.58746822
141regulation of coenzyme metabolic process (GO:0051196)2.58746822
142purine nucleoside biosynthetic process (GO:0042451)2.57622984
143purine ribonucleoside biosynthetic process (GO:0046129)2.57622984
144positive regulation of action potential (GO:0045760)2.56718352
145mitochondrion morphogenesis (GO:0070584)2.56476535
146translation (GO:0006412)2.56107317
147neurotransmitter uptake (GO:0001504)2.52590872
148translational elongation (GO:0006414)2.52535685
149mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.2086293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63409951
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.48760219
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.63793363
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.36149313
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30601021
6GBX2_23144817_ChIP-Seq_PC3_Human2.77999118
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.71696883
8TAF15_26573619_Chip-Seq_HEK293_Human2.70768458
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.59261853
10VDR_22108803_ChIP-Seq_LS180_Human2.48011971
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33413406
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.31045017
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29399392
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23160346
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21450216
16FOXP3_21729870_ChIP-Seq_TREG_Human2.21133527
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20824636
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10157530
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09952584
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.08062930
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06451984
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02203526
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96474353
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96116138
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95084484
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93779509
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.92925443
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88008038
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86084810
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85867363
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85104559
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82693185
33FUS_26573619_Chip-Seq_HEK293_Human1.79966897
34* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75176484
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71085132
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69547231
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69215743
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67080946
39* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66826683
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.66280680
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64836401
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.64727054
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60477171
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59356371
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59132052
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58956735
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55482993
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54609145
49ER_23166858_ChIP-Seq_MCF-7_Human1.52207564
50* SRF_21415370_ChIP-Seq_HL-1_Mouse1.52140119
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51916097
52XRN2_22483619_ChIP-Seq_HELA_Human1.51661998
53P300_19829295_ChIP-Seq_ESCs_Human1.46150760
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43434507
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42045137
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42045137
57REST_21632747_ChIP-Seq_MESCs_Mouse1.41591194
58* GABP_19822575_ChIP-Seq_HepG2_Human1.39594629
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39573031
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39487166
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.37870957
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36534101
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36314880
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.34216751
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34192168
66IGF1R_20145208_ChIP-Seq_DFB_Human1.33715113
67ZNF274_21170338_ChIP-Seq_K562_Hela1.33591545
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28977320
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27767774
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27566208
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27451451
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.26968188
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26686710
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.26141889
75TP53_22573176_ChIP-Seq_HFKS_Human1.26104343
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26081454
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25999467
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25885420
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25171171
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24411067
81* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21340285
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19351767
83* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19099260
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16434125
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.14617162
86* REST_18959480_ChIP-ChIP_MESCs_Mouse1.13567798
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11163768
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.10239490
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10220988
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10008533
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08268945
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.07569915
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.06552008
94DCP1A_22483619_ChIP-Seq_HELA_Human1.04936249
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04455588
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.03914290
97JUN_21703547_ChIP-Seq_K562_Human1.01577531
98EWS_26573619_Chip-Seq_HEK293_Human1.00393044
99IRF1_19129219_ChIP-ChIP_H3396_Human1.00333700
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99899078
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99359176
102SMAD4_21799915_ChIP-Seq_A2780_Human0.98787531
103ELK1_19687146_ChIP-ChIP_HELA_Human0.98633404
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.98480323
105* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97952924
106HTT_18923047_ChIP-ChIP_STHdh_Human0.97949185
107RNF2_27304074_Chip-Seq_NSC_Mouse0.97462454
108E2F7_22180533_ChIP-Seq_HELA_Human0.96457849
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95656776
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94855188
111* VDR_23849224_ChIP-Seq_CD4+_Human0.94537963
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94255156
113FOXA1_25329375_ChIP-Seq_VCAP_Human0.94255156
114RNF2_27304074_Chip-Seq_ESCs_Mouse0.93874926
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92057297
116* AR_20517297_ChIP-Seq_VCAP_Human0.91780531
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91260171
118TTF2_22483619_ChIP-Seq_HELA_Human0.90952684
119MYC_18555785_ChIP-Seq_MESCs_Mouse0.90163412
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90052742
121MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89229714
122MYC_18940864_ChIP-ChIP_HL60_Human0.87700706
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87587562
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.87213254
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87105942
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85682486
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84998465
128CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84424395
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84366029
130TAL1_26923725_Chip-Seq_HPCs_Mouse0.82306945
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.82176622
132SOX2_19829295_ChIP-Seq_ESCs_Human0.81686381
133NANOG_19829295_ChIP-Seq_ESCs_Human0.81686381
134REST_19997604_ChIP-ChIP_NEURONS_Mouse0.81302794
135SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80308938
136NCOR_22424771_ChIP-Seq_293T_Human0.78787960
137PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78542646
138* ERG_20517297_ChIP-Seq_VCAP_Human0.77525986
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76686134
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.76117480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.68877645
2MP0002837_dystrophic_cardiac_calcinosis4.49852181
3MP0001529_abnormal_vocalization3.78680917
4MP0009379_abnormal_foot_pigmentation3.31063211
5MP0001905_abnormal_dopamine_level2.91439271
6MP0006276_abnormal_autonomic_nervous2.82071588
7MP0003806_abnormal_nucleotide_metabolis2.73799624
8MP0000751_myopathy2.68177421
9MP0003646_muscle_fatigue2.61792260
10MP0004215_abnormal_myocardial_fiber2.57246035
11MP0006292_abnormal_olfactory_placode2.47987139
12MP0008058_abnormal_DNA_repair2.33321105
13MP0003186_abnormal_redox_activity2.30142800
14MP0002736_abnormal_nociception_after2.26084518
15MP0009745_abnormal_behavioral_response2.25210957
16MP0009046_muscle_twitch2.21527779
17MP0002064_seizures2.17450583
18MP0001968_abnormal_touch/_nociception2.16626055
19MP0002272_abnormal_nervous_system2.12608784
20MP0006036_abnormal_mitochondrial_physio2.08655035
21MP0003635_abnormal_synaptic_transmissio2.08187861
22MP0001440_abnormal_grooming_behavior2.08099787
23MP0002938_white_spotting2.00054667
24MP0004036_abnormal_muscle_relaxation1.98596562
25MP0004142_abnormal_muscle_tone1.95486466
26MP0002572_abnormal_emotion/affect_behav1.86446097
27MP0004084_abnormal_cardiac_muscle1.85141150
28MP0009697_abnormal_copulation1.82235934
29MP0000749_muscle_degeneration1.82124715
30MP0008877_abnormal_DNA_methylation1.81835583
31MP0006035_abnormal_mitochondrial_morpho1.79772663
32MP0005423_abnormal_somatic_nervous1.75787960
33MP0003137_abnormal_impulse_conducting1.75266872
34MP0003011_delayed_dark_adaptation1.72826409
35MP0004957_abnormal_blastocyst_morpholog1.72704131
36MP0005409_darkened_coat_color1.72341550
37MP0008995_early_reproductive_senescence1.72211631
38MP0001486_abnormal_startle_reflex1.71647254
39MP0005084_abnormal_gallbladder_morpholo1.71156864
40MP0002735_abnormal_chemical_nociception1.69112133
41MP0003136_yellow_coat_color1.67568581
42MP0004859_abnormal_synaptic_plasticity1.66436969
43MP0004145_abnormal_muscle_electrophysio1.66271665
44MP0005330_cardiomyopathy1.66200700
45MP0002063_abnormal_learning/memory/cond1.66065803
46MP0002822_catalepsy1.65186566
47MP0005386_behavior/neurological_phenoty1.63377271
48MP0004924_abnormal_behavior1.63377271
49MP0003786_premature_aging1.62496623
50MP0002734_abnormal_mechanical_nocicepti1.59708652
51MP0010094_abnormal_chromosome_stability1.59453561
52MP0004270_analgesia1.55634831
53MP0002067_abnormal_sensory_capabilities1.55035877
54MP0003718_maternal_effect1.53129507
55MP0008875_abnormal_xenobiotic_pharmacok1.51786684
56MP0001188_hyperpigmentation1.51366049
57MP0003195_calcinosis1.49484243
58MP0001501_abnormal_sleep_pattern1.47244297
59MP0005253_abnormal_eye_physiology1.47100109
60MP0002277_abnormal_respiratory_mucosa1.46637287
61MP0004484_altered_response_of1.44485454
62MP0001970_abnormal_pain_threshold1.40830700
63MP0002234_abnormal_pharynx_morphology1.38597863
64MP0003693_abnormal_embryo_hatching1.38027007
65MP0008789_abnormal_olfactory_epithelium1.33753769
66MP0004133_heterotaxia1.32197147
67MP0002972_abnormal_cardiac_muscle1.30335683
68MP0005075_abnormal_melanosome_morpholog1.29153824
69MP0004085_abnormal_heartbeat1.27181411
70MP0001984_abnormal_olfaction1.25847111
71MP0002733_abnormal_thermal_nociception1.25433011
72MP0006072_abnormal_retinal_apoptosis1.24620292
73MP0002638_abnormal_pupillary_reflex1.24358739
74MP0005620_abnormal_muscle_contractility1.20657423
75MP0000778_abnormal_nervous_system1.20459186
76MP0005171_absent_coat_pigmentation1.20327930
77MP0002163_abnormal_gland_morphology1.19918267
78MP0002332_abnormal_exercise_endurance1.18510315
79MP0005379_endocrine/exocrine_gland_phen1.18338177
80MP0005408_hypopigmentation1.17225562
81MP0005551_abnormal_eye_electrophysiolog1.16878385
82MP0004742_abnormal_vestibular_system1.16805982
83MP0004043_abnormal_pH_regulation1.15884275
84MP0001293_anophthalmia1.14785413
85MP0001485_abnormal_pinna_reflex1.13936312
86MP0003122_maternal_imprinting1.13837134
87MP0001764_abnormal_homeostasis1.11863542
88MP0002106_abnormal_muscle_physiology1.11722133
89MP0002557_abnormal_social/conspecific_i1.10930516
90MP0002184_abnormal_innervation1.09456896
91MP0002090_abnormal_vision1.09089710
92MP0003077_abnormal_cell_cycle1.08388268
93MP0000920_abnormal_myelination1.08385243
94MP0000750_abnormal_muscle_regeneration1.04848260
95MP0003329_amyloid_beta_deposits1.04407287
96MP0005645_abnormal_hypothalamus_physiol1.04163614
97MP0008872_abnormal_physiological_respon1.03945162
98MP0002066_abnormal_motor_capabilities/c1.02382362
99MP0004147_increased_porphyrin_level1.01917483
100MP0008932_abnormal_embryonic_tissue1.01286287
101MP0003567_abnormal_fetal_cardiomyocyte1.01220061
102MP0002095_abnormal_skin_pigmentation1.00430855
103MP0005389_reproductive_system_phenotype1.00043837
104MP0003121_genomic_imprinting0.98411055
105MP0001727_abnormal_embryo_implantation0.98341293
106MP0000747_muscle_weakness0.98136964
107MP0002160_abnormal_reproductive_system0.97991760
108MP0005369_muscle_phenotype0.96545587
109MP0000516_abnormal_urinary_system0.95121562
110MP0005367_renal/urinary_system_phenotyp0.95121562
111MP0002751_abnormal_autonomic_nervous0.95113105
112MP0002876_abnormal_thyroid_physiology0.94429746
113MP0000372_irregular_coat_pigmentation0.94034865
114MP0006138_congestive_heart_failure0.93836368
115MP0005535_abnormal_body_temperature0.93480639
116MP0002102_abnormal_ear_morphology0.93243017
117MP0002210_abnormal_sex_determination0.90779162
118MP0003950_abnormal_plasma_membrane0.89926101
119MP0002229_neurodegeneration0.89749653
120MP0005646_abnormal_pituitary_gland0.87785662
121MP0001919_abnormal_reproductive_system0.87745166
122MP0005332_abnormal_amino_acid0.87486055
123MP0002882_abnormal_neuron_morphology0.86698751
124MP0001664_abnormal_digestion0.86302885
125MP0005385_cardiovascular_system_phenoty0.85916895
126MP0001544_abnormal_cardiovascular_syste0.85916895
127MP0005195_abnormal_posterior_eye0.85617785
128MP0008775_abnormal_heart_ventricle0.84404814
129MP0010386_abnormal_urinary_bladder0.82803629
130MP0003111_abnormal_nucleus_morphology0.82610339
131MP0001963_abnormal_hearing_physiology0.82372881
132MP0008007_abnormal_cellular_replicative0.79504489
133MP0000026_abnormal_inner_ear0.79419199
134MP0008569_lethality_at_weaning0.79207874
135MP0002752_abnormal_somatic_nervous0.79170653
136MP0005410_abnormal_fertilization0.77147313
137MP0002282_abnormal_trachea_morphology0.76457870
138MP0000230_abnormal_systemic_arterial0.76274933
139MP0000631_abnormal_neuroendocrine_gland0.76268846
140MP0001346_abnormal_lacrimal_gland0.76003113
141MP0000759_abnormal_skeletal_muscle0.75831881
142MP0003787_abnormal_imprinting0.75577132
143MP0005266_abnormal_metabolism0.75361471
144MP0004087_abnormal_muscle_fiber0.75204778
145MP0005636_abnormal_mineral_homeostasis0.74094061
146MP0001929_abnormal_gametogenesis0.73292017
147MP0005394_taste/olfaction_phenotype0.72658970
148MP0005499_abnormal_olfactory_system0.72658970
149MP0003937_abnormal_limbs/digits/tail_de0.72265420
150MP0003283_abnormal_digestive_organ0.72199164
151MP0000013_abnormal_adipose_tissue0.71573046
152MP0001986_abnormal_taste_sensitivity0.71116977
153MP0002127_abnormal_cardiovascular_syste0.69982676
154MP0000647_abnormal_sebaceous_gland0.69863437
155MP0000653_abnormal_sex_gland0.69821486

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.77648086
2Abnormal mitochondria in muscle tissue (HP:0008316)7.13763358
3Progressive macrocephaly (HP:0004481)6.66579963
4* Mitochondrial inheritance (HP:0001427)6.48347918
5Acute encephalopathy (HP:0006846)6.39373486
6* Increased CSF lactate (HP:0002490)5.51815551
7Increased hepatocellular lipid droplets (HP:0006565)5.19784850
8* Hepatocellular necrosis (HP:0001404)5.06602269
9Lipid accumulation in hepatocytes (HP:0006561)4.69710326
10Cerebral edema (HP:0002181)4.50873041
11* Hepatic necrosis (HP:0002605)4.43011236
12Renal Fanconi syndrome (HP:0001994)4.36473961
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.30905326
14Increased intramyocellular lipid droplets (HP:0012240)4.23015800
15Optic disc pallor (HP:0000543)4.15557436
16Exercise intolerance (HP:0003546)4.10723731
17Abnormality of glycolysis (HP:0004366)3.97058632
18Increased serum pyruvate (HP:0003542)3.97058632
19* Respiratory failure (HP:0002878)3.84281655
20Leukodystrophy (HP:0002415)3.83152369
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.81650452
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.77933110
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.77933110
24* Lactic acidosis (HP:0003128)3.75573256
25Increased muscle lipid content (HP:0009058)3.69415173
263-Methylglutaconic aciduria (HP:0003535)3.49628366
27Congenital, generalized hypertrichosis (HP:0004540)3.32935001
28* Increased serum lactate (HP:0002151)3.26008640
29Exertional dyspnea (HP:0002875)3.15294630
30Muscle hypertrophy of the lower extremities (HP:0008968)3.06832581
31Calf muscle hypertrophy (HP:0008981)2.94975310
32Respiratory difficulties (HP:0002880)2.94735382
33Abnormality of renal resorption (HP:0011038)2.94425566
34Neuroendocrine neoplasm (HP:0100634)2.94232854
35Pheochromocytoma (HP:0002666)2.93987697
36Sudden death (HP:0001699)2.87602222
37Reticulocytopenia (HP:0001896)2.82332524
38Focal motor seizures (HP:0011153)2.80912463
39X-linked dominant inheritance (HP:0001423)2.71269908
40Aplastic anemia (HP:0001915)2.70318634
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64550868
42Pancreatic cysts (HP:0001737)2.48609855
43Abnormality of midbrain morphology (HP:0002418)2.47366991
44Molar tooth sign on MRI (HP:0002419)2.47366991
45Colon cancer (HP:0003003)2.41801886
46Generalized aminoaciduria (HP:0002909)2.37131606
47Limb dystonia (HP:0002451)2.35881737
48Pancreatic fibrosis (HP:0100732)2.30352874
49Parakeratosis (HP:0001036)2.29804395
50Abnormal ciliary motility (HP:0012262)2.26955591
51Lethargy (HP:0001254)2.25092013
52Abnormality of cells of the erythroid lineage (HP:0012130)2.24209937
53Abnormal pupillary function (HP:0007686)2.23639601
54True hermaphroditism (HP:0010459)2.23512899
55Glycosuria (HP:0003076)2.21994471
56Abnormality of urine glucose concentration (HP:0011016)2.21994471
57Hyperphosphaturia (HP:0003109)2.21883582
58Type I transferrin isoform profile (HP:0003642)2.17777927
59Abnormality of the calf musculature (HP:0001430)2.13569161
60Oral leukoplakia (HP:0002745)2.13062223
61* Emotional lability (HP:0000712)2.12890176
62Myokymia (HP:0002411)2.12166255
63Medial flaring of the eyebrow (HP:0010747)2.12113833
64* CNS demyelination (HP:0007305)2.10468789
65Hyperventilation (HP:0002883)2.06282020
66Abnormal number of erythroid precursors (HP:0012131)2.05802531
67Hypothermia (HP:0002045)2.04849764
68Palpitations (HP:0001962)2.03610472
69Progressive external ophthalmoplegia (HP:0000590)2.01452176
70Methylmalonic acidemia (HP:0002912)2.00573315
71Abnormality of the labia minora (HP:0012880)2.00300707
72Abnormal respiratory motile cilium morphology (HP:0005938)1.99329056
73Abnormal respiratory epithelium morphology (HP:0012253)1.99329056
74Methylmalonic aciduria (HP:0012120)1.99290152
75Nephronophthisis (HP:0000090)1.97758292
76Cerebral hemorrhage (HP:0001342)1.96396586
77Atonic seizures (HP:0010819)1.94914288
78Macrocytic anemia (HP:0001972)1.92519494
79Pallor (HP:0000980)1.92457346
80Abnormal urine phosphate concentration (HP:0012599)1.90346651
81Exercise-induced myalgia (HP:0003738)1.87410483
82Hyperglycinemia (HP:0002154)1.87403905
83Abnormal respiratory motile cilium physiology (HP:0012261)1.86536350
84Gait imbalance (HP:0002141)1.85438647
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.85118276
86Absent/shortened dynein arms (HP:0200106)1.85118276
87Ventricular tachycardia (HP:0004756)1.84579597
88Hypoplastic left heart (HP:0004383)1.83727622
89Muscle fiber splitting (HP:0003555)1.83248837
90Sclerocornea (HP:0000647)1.81564031
91Conjunctival hamartoma (HP:0100780)1.81403829
92Abnormality of alanine metabolism (HP:0010916)1.81364118
93Hyperalaninemia (HP:0003348)1.81364118
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81364118
95Syncope (HP:0001279)1.80573534
96Retinal dysplasia (HP:0007973)1.79946680
97Atrial fibrillation (HP:0005110)1.79658854
98Septo-optic dysplasia (HP:0100842)1.79406848
99Supraventricular tachycardia (HP:0004755)1.79127384
100Delusions (HP:0000746)1.79115888
101Congenital primary aphakia (HP:0007707)1.78140140
102Pancytopenia (HP:0001876)1.77462520
103Abnormality of the anterior horn cell (HP:0006802)1.76906200
104Degeneration of anterior horn cells (HP:0002398)1.76906200
105Abnormality of serum amino acid levels (HP:0003112)1.76425705
106Primary atrial arrhythmia (HP:0001692)1.75762261
107Prolonged QT interval (HP:0001657)1.75387666
108Renal tubular dysfunction (HP:0000124)1.75095684
109Meckel diverticulum (HP:0002245)1.74732148
110Blindness (HP:0000618)1.73971122
111Aplasia/hypoplasia of the uterus (HP:0008684)1.73312558
112Myotonia (HP:0002486)1.72835488
113Abnormality of placental membranes (HP:0011409)1.72351472
114Amniotic constriction ring (HP:0009775)1.72351472
115Microvesicular hepatic steatosis (HP:0001414)1.71673080
116Abnormality of the ileum (HP:0001549)1.71557962
117Supraventricular arrhythmia (HP:0005115)1.70688266
118Renal cortical cysts (HP:0000803)1.70660122
119Ragged-red muscle fibers (HP:0003200)1.70116615
120Absence seizures (HP:0002121)1.69651252
121Anxiety (HP:0000739)1.69584725
122Congenital stationary night blindness (HP:0007642)1.68751787
123Epileptic encephalopathy (HP:0200134)1.68708047
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68635964
125Vomiting (HP:0002013)1.68584951
126Left ventricular hypertrophy (HP:0001712)1.68120530
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.67540553
128Congenital ichthyosiform erythroderma (HP:0007431)1.66164623
129Dicarboxylic aciduria (HP:0003215)1.65546848
130Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65546848
131Dialeptic seizures (HP:0011146)1.64749886
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.63316898
133Type 2 muscle fiber atrophy (HP:0003554)1.61124257
134Absent thumb (HP:0009777)1.60936130
135Abnormality of methionine metabolism (HP:0010901)1.58805985
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.58781150
137Abnormal protein N-linked glycosylation (HP:0012347)1.58781150
138Abnormal protein glycosylation (HP:0012346)1.58781150
139Abnormal glycosylation (HP:0012345)1.58781150
140Absent septum pellucidum (HP:0001331)1.58636821
141Abnormality of the renal cortex (HP:0011035)1.55965537
142Male pseudohermaphroditism (HP:0000037)1.55090662
143Stenosis of the external auditory canal (HP:0000402)1.53028064
144Abnormality of the renal medulla (HP:0100957)1.52594614
145Short tibia (HP:0005736)1.50980846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.42909641
2NME13.84935878
3MAP3K123.19599831
4CASK2.87809535
5PNCK2.83078160
6STK392.77813292
7STK162.68125364
8MYLK2.61401717
9ZAK2.54357211
10MAP4K22.36594582
11MUSK2.06323795
12OXSR12.06005550
13GRK72.05180797
14MAP2K72.00872631
15MAPKAPK52.00265366
16NUAK11.99787543
17TNIK1.98467241
18CDC71.95199389
19WNK41.91316666
20NEK11.91270025
21TLK11.79337073
22NME21.76712091
23MST41.75639791
24EPHA41.72634325
25PBK1.67649693
26GRK51.62787083
27ARAF1.62750679
28NTRK31.60289722
29TAF11.59776783
30MAP3K41.59756126
31OBSCN1.58232215
32CDK191.56149804
33BCR1.48613202
34TAOK21.47932038
35PLK31.46679303
36PHKG11.44512649
37PHKG21.44512649
38PLK21.38705604
39TRIM281.36999255
40PDK31.35982613
41PDK41.35982613
42PLK41.34857506
43VRK11.33987197
44CAMK2D1.32791900
45ADRBK21.32321812
46CAMK2A1.30774084
47CCNB11.28672215
48FRK1.22430834
49CAMK2B1.22299221
50LMTK21.21949785
51GRK11.21726173
52BMPR1B1.19286295
53PKN11.18260999
54MARK11.14609494
55MAP2K61.13035841
56BUB11.02860843
57ERBB31.01743931
58FGR1.01509941
59UHMK10.99551906
60MAPK130.97953960
61BMPR20.97597926
62ROCK20.96282764
63MINK10.95631750
64MKNK20.94590528
65FES0.93822534
66KDR0.93110757
67CSNK1G30.93040915
68PLK10.91846894
69PIK3CA0.91038650
70TTK0.90597225
71INSRR0.90312275
72LIMK10.89269025
73ADRBK10.88719453
74MAP2K40.87857282
75EIF2AK10.87190523
76CAMK2G0.86964411
77RIPK40.86065029
78PASK0.85114358
79MKNK10.84923404
80PRKCE0.84478325
81TXK0.82786209
82PTK2B0.81955671
83IRAK20.79491445
84BCKDK0.78332593
85TSSK60.77622036
86AURKB0.77356328
87PDK20.75514176
88DAPK30.74831416
89PAK30.72047243
90SRPK10.71413898
91BRAF0.70085525
92PRKACA0.68392611
93PRKCG0.67379523
94CSNK1A1L0.65098099
95TESK20.63577569
96BRSK20.63126712
97ABL20.61524132
98CSNK1G20.60840615
99TESK10.60186909
100WNK30.60117650
101ILK0.58593301
102EIF2AK30.58584701
103TIE10.57264088
104PINK10.56062447
105GRK60.55903486
106ATR0.55786697
107CHEK20.55607015
108CDK50.55225737
109CDK140.54795800
110DYRK20.54398653
111NTRK20.51481390
112MAP3K50.50237516
113TAOK30.50020127
114CSNK1G10.49231224
115TTN0.47555320
116CDK180.46002278
117CDK150.44399516
118EIF2AK20.43960018
119CDK11A0.43937531
120ROCK10.43013456
121CDK80.42546685
122DYRK1A0.42418656
123STK40.42225901
124NTRK10.41394173
125CSNK1A10.40530362
126CSNK2A20.39839804
127DYRK30.39202019
128WEE10.39080026
129RPS6KA50.37976008
130RPS6KA40.37660882
131PRKACB0.36952939
132DAPK10.35480023
133PRKCQ0.35199210
134PRKG10.34591748
135CSNK2A10.34516177
136AURKA0.34155199
137MAPK120.33204359
138CAMK10.32203499
139MAPK150.31402762

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.75937231
2Parkinsons disease_Homo sapiens_hsa050125.81232629
3Alzheimers disease_Homo sapiens_hsa050104.48169622
4Huntingtons disease_Homo sapiens_hsa050164.06062126
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.52364944
6Cardiac muscle contraction_Homo sapiens_hsa042603.47760299
7Ribosome_Homo sapiens_hsa030103.21801984
8Proteasome_Homo sapiens_hsa030502.63496873
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.30836275
10Protein export_Homo sapiens_hsa030602.20269764
11Collecting duct acid secretion_Homo sapiens_hsa049662.11055258
12Mismatch repair_Homo sapiens_hsa034302.01241026
13Nicotine addiction_Homo sapiens_hsa050331.90220497
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89035322
15Fatty acid elongation_Homo sapiens_hsa000621.83123301
16DNA replication_Homo sapiens_hsa030301.79847371
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78435291
18RNA polymerase_Homo sapiens_hsa030201.77938687
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52127306
20Propanoate metabolism_Homo sapiens_hsa006401.40188389
21RNA degradation_Homo sapiens_hsa030181.39392503
22Pyruvate metabolism_Homo sapiens_hsa006201.35108890
23Vibrio cholerae infection_Homo sapiens_hsa051101.29729845
24Fanconi anemia pathway_Homo sapiens_hsa034601.26645547
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25909504
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23498306
27Synaptic vesicle cycle_Homo sapiens_hsa047211.19962447
28One carbon pool by folate_Homo sapiens_hsa006701.19748669
29Folate biosynthesis_Homo sapiens_hsa007901.17055196
30Serotonergic synapse_Homo sapiens_hsa047261.10940605
31Base excision repair_Homo sapiens_hsa034101.06459434
32RNA transport_Homo sapiens_hsa030131.05783553
33GABAergic synapse_Homo sapiens_hsa047271.02417130
34Sulfur metabolism_Homo sapiens_hsa009200.98652790
35Butanoate metabolism_Homo sapiens_hsa006500.95109657
36Taste transduction_Homo sapiens_hsa047420.92605716
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89767651
38Non-homologous end-joining_Homo sapiens_hsa034500.88247910
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87012897
40Morphine addiction_Homo sapiens_hsa050320.85695807
41Phototransduction_Homo sapiens_hsa047440.84544873
42Amphetamine addiction_Homo sapiens_hsa050310.83933263
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82418316
44* Metabolic pathways_Homo sapiens_hsa011000.80263222
45Asthma_Homo sapiens_hsa053100.79225261
46Glutamatergic synapse_Homo sapiens_hsa047240.79032568
47Nitrogen metabolism_Homo sapiens_hsa009100.77738577
48Carbon metabolism_Homo sapiens_hsa012000.77492031
49Circadian entrainment_Homo sapiens_hsa047130.77181518
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.74740473
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74650033
52Dopaminergic synapse_Homo sapiens_hsa047280.73275130
53Pyrimidine metabolism_Homo sapiens_hsa002400.73148839
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72022445
55Calcium signaling pathway_Homo sapiens_hsa040200.71043462
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70807829
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67824404
58Ether lipid metabolism_Homo sapiens_hsa005650.67072553
59Renin secretion_Homo sapiens_hsa049240.65799420
60Dilated cardiomyopathy_Homo sapiens_hsa054140.65272934
61Tryptophan metabolism_Homo sapiens_hsa003800.65141403
62Rheumatoid arthritis_Homo sapiens_hsa053230.64164890
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64124552
64Long-term depression_Homo sapiens_hsa047300.63694090
65Tyrosine metabolism_Homo sapiens_hsa003500.62411341
66Steroid biosynthesis_Homo sapiens_hsa001000.62358766
67Long-term potentiation_Homo sapiens_hsa047200.62342667
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61513907
69Caffeine metabolism_Homo sapiens_hsa002320.61268494
70Cocaine addiction_Homo sapiens_hsa050300.60345887
71Regulation of autophagy_Homo sapiens_hsa041400.59615108
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59138369
73Chemical carcinogenesis_Homo sapiens_hsa052040.58332014
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57807888
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57628529
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57284323
77Salivary secretion_Homo sapiens_hsa049700.56225309
78Purine metabolism_Homo sapiens_hsa002300.56167356
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54867437
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54132651
81Selenocompound metabolism_Homo sapiens_hsa004500.51124048
82Gastric acid secretion_Homo sapiens_hsa049710.49941049
83Phenylalanine metabolism_Homo sapiens_hsa003600.49783483
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49376890
85Olfactory transduction_Homo sapiens_hsa047400.47997031
86Cholinergic synapse_Homo sapiens_hsa047250.46341061
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46111881
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44815534
89Systemic lupus erythematosus_Homo sapiens_hsa053220.43577007
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.43349114
91Arginine and proline metabolism_Homo sapiens_hsa003300.42885565
92Sulfur relay system_Homo sapiens_hsa041220.42820262
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.42011514
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40250984
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39445855
96Glutathione metabolism_Homo sapiens_hsa004800.38124444
97Type I diabetes mellitus_Homo sapiens_hsa049400.38051388
98Linoleic acid metabolism_Homo sapiens_hsa005910.37825598
99Autoimmune thyroid disease_Homo sapiens_hsa053200.37433796
100Arachidonic acid metabolism_Homo sapiens_hsa005900.37306254
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36996855
102Retinol metabolism_Homo sapiens_hsa008300.36657674
103Cell cycle_Homo sapiens_hsa041100.36640624
104beta-Alanine metabolism_Homo sapiens_hsa004100.36396252
105Fatty acid metabolism_Homo sapiens_hsa012120.35732026
106Allograft rejection_Homo sapiens_hsa053300.34287063
107Insulin secretion_Homo sapiens_hsa049110.34262071
108Oxytocin signaling pathway_Homo sapiens_hsa049210.34185059
109Spliceosome_Homo sapiens_hsa030400.33481341
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.33015359
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32505418
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.32453288
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.32165887
114Oocyte meiosis_Homo sapiens_hsa041140.31252287
115Graft-versus-host disease_Homo sapiens_hsa053320.30616449
116Vitamin B6 metabolism_Homo sapiens_hsa007500.30204507
117Peroxisome_Homo sapiens_hsa041460.29486930
118Basal transcription factors_Homo sapiens_hsa030220.29407737
119Sphingolipid metabolism_Homo sapiens_hsa006000.27998030
120Phagosome_Homo sapiens_hsa041450.27466464
121Primary immunodeficiency_Homo sapiens_hsa053400.27205117
122Gap junction_Homo sapiens_hsa045400.26156975
123Alcoholism_Homo sapiens_hsa050340.25702516
124Fatty acid degradation_Homo sapiens_hsa000710.23265532
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21516714
126Pancreatic secretion_Homo sapiens_hsa049720.20231281
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.20057157
128Axon guidance_Homo sapiens_hsa043600.19582366
129Mineral absorption_Homo sapiens_hsa049780.18939236
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18666207
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18585126
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17799477
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17518835
134Epstein-Barr virus infection_Homo sapiens_hsa051690.17444497
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16534556
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15277184
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15107888
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14491590
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13980650
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13856379
141Histidine metabolism_Homo sapiens_hsa003400.13740875
142Nucleotide excision repair_Homo sapiens_hsa034200.12986291
143Homologous recombination_Homo sapiens_hsa034400.11870547
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11580620
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10856372

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