NDUFA13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.51620962
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.11530622
3ATP synthesis coupled proton transport (GO:0015986)8.97639683
4energy coupled proton transport, down electrochemical gradient (GO:0015985)8.97639683
5* respiratory electron transport chain (GO:0022904)8.13314710
6* electron transport chain (GO:0022900)7.93163111
7viral transcription (GO:0019083)6.35779489
8ribosomal small subunit assembly (GO:0000028)6.18440641
9translational termination (GO:0006415)6.09540229
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.71759959
11cotranslational protein targeting to membrane (GO:0006613)5.67264024
12protein targeting to ER (GO:0045047)5.63798281
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.38306468
14protein localization to endoplasmic reticulum (GO:0070972)5.33971819
15ATP biosynthetic process (GO:0006754)5.25435943
16translational elongation (GO:0006414)5.21733297
17ribosomal small subunit biogenesis (GO:0042274)5.10854979
18hydrogen ion transmembrane transport (GO:1902600)4.92309365
19oxidative phosphorylation (GO:0006119)4.92147009
20protein complex biogenesis (GO:0070271)4.77008219
21purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.73235233
22viral life cycle (GO:0019058)4.71335483
23cellular protein complex disassembly (GO:0043624)4.69526111
24maturation of SSU-rRNA (GO:0030490)4.69162178
25proteasome assembly (GO:0043248)4.68457683
26purine nucleoside triphosphate biosynthetic process (GO:0009145)4.67115932
27chaperone-mediated protein transport (GO:0072321)4.60392786
28mitochondrial respiratory chain complex I assembly (GO:0032981)4.50550610
29NADH dehydrogenase complex assembly (GO:0010257)4.50550610
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.50550610
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.45414968
32tricarboxylic acid cycle (GO:0006099)4.39575441
33translational initiation (GO:0006413)4.35542071
34proton transport (GO:0015992)4.34498399
35mitochondrial respiratory chain complex assembly (GO:0033108)4.33662916
36hydrogen transport (GO:0006818)4.28607877
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.25212441
38transcription elongation from RNA polymerase III promoter (GO:0006385)4.19679909
39termination of RNA polymerase III transcription (GO:0006386)4.19679909
40sequestering of actin monomers (GO:0042989)4.16084684
41translation (GO:0006412)4.12509636
42protein neddylation (GO:0045116)4.12005975
43ribonucleoside triphosphate biosynthetic process (GO:0009201)4.10094657
44regulation of cellular amino acid metabolic process (GO:0006521)3.98136106
45NADH metabolic process (GO:0006734)3.95328959
46protein complex disassembly (GO:0043241)3.93211176
47negative regulation of ligase activity (GO:0051352)3.89094321
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.89094321
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82999773
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.77197802
51protein targeting to membrane (GO:0006612)3.74153031
52macromolecular complex disassembly (GO:0032984)3.72972300
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.72763825
54succinate metabolic process (GO:0006105)3.70072479
55regulation of oxidative phosphorylation (GO:0002082)3.69829577
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.65335109
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.65335109
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.65335109
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.64935686
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.64935686
61ATP hydrolysis coupled proton transport (GO:0015991)3.59237160
62energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.59237160
63ribosomal large subunit biogenesis (GO:0042273)3.58158097
64aerobic respiration (GO:0009060)3.53582601
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.50548979
66signal transduction involved in DNA damage checkpoint (GO:0072422)3.50548979
67nucleoside triphosphate biosynthetic process (GO:0009142)3.49986859
68rRNA modification (GO:0000154)3.48518227
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48363633
70positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.46029480
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.44598039
72* inner mitochondrial membrane organization (GO:0007007)3.43428905
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.39873344
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.39873344
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34424218
76cellular component biogenesis (GO:0044085)3.33848037
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27551410
78platelet dense granule organization (GO:0060155)3.24714165
79pseudouridine synthesis (GO:0001522)3.22665484
80regulation of cell communication by electrical coupling (GO:0010649)3.22051142
81* protein localization to mitochondrion (GO:0070585)3.20438789
82sarcomere organization (GO:0045214)3.20341859
83DNA deamination (GO:0045006)3.19474955
84nuclear-transcribed mRNA catabolic process (GO:0000956)3.17168490
85* generation of precursor metabolites and energy (GO:0006091)3.16442870
86regulation of mitochondrial translation (GO:0070129)3.14962187
87spliceosomal snRNP assembly (GO:0000387)3.14611470
88positive regulation of ligase activity (GO:0051351)3.11755814
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11274377
90regulation of cellular respiration (GO:0043457)3.10431321
91muscle filament sliding (GO:0030049)3.09153588
92actin-myosin filament sliding (GO:0033275)3.09153588
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.07062152
94cytochrome complex assembly (GO:0017004)3.05405286
95regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.05212042
96heart process (GO:0003015)3.04340309
97heart contraction (GO:0060047)3.04340309
98regulation of cellular amine metabolic process (GO:0033238)3.03663737
99negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.03223381
100quinone biosynthetic process (GO:1901663)3.00874679
101ubiquinone biosynthetic process (GO:0006744)3.00874679
102* mitochondrial transport (GO:0006839)3.00379925
103regulation of acyl-CoA biosynthetic process (GO:0050812)2.99118425
104mRNA catabolic process (GO:0006402)2.98972831
105purine nucleoside monophosphate biosynthetic process (GO:0009127)2.97673031
106purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.97673031
107respiratory chain complex IV assembly (GO:0008535)2.97284794
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93654047
109regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92723607
110GTP biosynthetic process (GO:0006183)2.90532749
111cellular ketone body metabolic process (GO:0046950)2.90316298
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89163212
113regulation of ubiquitin-protein transferase activity (GO:0051438)2.86965969
114nucleoside monophosphate biosynthetic process (GO:0009124)2.84612279
115dopamine transport (GO:0015872)2.84238513
116fatty acid elongation (GO:0030497)2.83461950
117aldehyde catabolic process (GO:0046185)2.82590014
118regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.82470087
119sarcoplasmic reticulum calcium ion transport (GO:0070296)2.82386642
120antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81965219
121regulation of relaxation of muscle (GO:1901077)2.80884342
122positive regulation of cell cycle arrest (GO:0071158)2.80620546
123substantia nigra development (GO:0021762)2.77103213
124regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.73837893
125branched-chain amino acid catabolic process (GO:0009083)2.73644048
126negative regulation of protein localization to cell surface (GO:2000009)2.72352848
127oxaloacetate metabolic process (GO:0006107)2.71103383
128ubiquinone metabolic process (GO:0006743)2.70928738
129regulation of coenzyme metabolic process (GO:0051196)2.69706829
130regulation of cofactor metabolic process (GO:0051193)2.69706829
131purine ribonucleoside biosynthetic process (GO:0046129)2.69517387
132purine nucleoside biosynthetic process (GO:0042451)2.69517387
133protein targeting to mitochondrion (GO:0006626)2.63349431
134cellular respiration (GO:0045333)2.62578540
135calcium-mediated signaling using intracellular calcium source (GO:0035584)2.61794837
136regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.60723755
137creatine metabolic process (GO:0006600)2.59333476
138regulation of actin filament-based movement (GO:1903115)2.58110027
139ketone body metabolic process (GO:1902224)2.56248994
140myofibril assembly (GO:0030239)2.52724260
141detection of calcium ion (GO:0005513)2.49348760
142actin-mediated cell contraction (GO:0070252)2.49001928
143aspartate family amino acid catabolic process (GO:0009068)2.48483172
144cardiac muscle contraction (GO:0060048)2.48478203
145short-chain fatty acid metabolic process (GO:0046459)2.46598039
146regulation of skeletal muscle contraction (GO:0014819)2.44326399
147axon ensheathment in central nervous system (GO:0032291)2.43700073
148central nervous system myelination (GO:0022010)2.43700073
149response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.43418512
150positive regulation of action potential (GO:0045760)2.41689448
151cardiac myofibril assembly (GO:0055003)2.39853373
152negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.38590615
153negative regulation of calcium ion transmembrane transport (GO:1903170)2.38590615
154negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.36161880
155regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.35734311
156* establishment of protein localization to mitochondrial membrane (GO:0090151)2.35367439
157* establishment of protein localization to mitochondrion (GO:0072655)2.34170243
158regulation of striated muscle contraction (GO:0006942)2.30782659
159regulation of protein kinase A signaling (GO:0010738)2.29576019
160ribonucleoside monophosphate biosynthetic process (GO:0009156)2.29267670
161protein-cofactor linkage (GO:0018065)2.28704402
162branched-chain amino acid metabolic process (GO:0009081)2.27201329
163regulation of dopamine metabolic process (GO:0042053)2.26449613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.72823292
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.45922239
3EZH2_22144423_ChIP-Seq_EOC_Human3.26702709
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.24531030
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18844730
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82602664
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65853588
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59351004
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.39492189
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34092660
11VDR_22108803_ChIP-Seq_LS180_Human2.30490412
12* VDR_23849224_ChIP-Seq_CD4+_Human2.25480969
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17677798
14XRN2_22483619_ChIP-Seq_HELA_Human2.17481639
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12577312
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11205697
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10520506
18FOXP3_21729870_ChIP-Seq_TREG_Human2.09220555
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04673831
20E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04102306
21GBX2_23144817_ChIP-Seq_PC3_Human1.98059238
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.97602770
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97478498
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96676939
25ELK1_19687146_ChIP-ChIP_HELA_Human1.95935454
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91730498
27* TTF2_22483619_ChIP-Seq_HELA_Human1.91473025
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.91418309
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.89343861
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88222680
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84875718
32TAF15_26573619_Chip-Seq_HEK293_Human1.84264485
33DCP1A_22483619_ChIP-Seq_HELA_Human1.81787704
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.74257902
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73593499
36* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69549398
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69021795
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.68724049
39GABP_19822575_ChIP-Seq_HepG2_Human1.67879589
40MYC_18940864_ChIP-ChIP_HL60_Human1.65055616
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.61460708
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59854704
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57383795
44* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56045028
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54065362
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49866694
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.49355542
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48495401
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47017584
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44455147
51* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44026779
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40737576
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40131447
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37719851
55* ETS1_20019798_ChIP-Seq_JURKAT_Human1.36285649
56* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36213585
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.35869133
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34949344
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34949344
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34314698
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32911902
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31795137
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31205413
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30815800
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28400551
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27981697
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27315474
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27025008
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26590569
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24879261
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.22230820
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22100321
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21381614
74HTT_18923047_ChIP-ChIP_STHdh_Human1.20732473
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.20182993
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19746464
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19168588
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16508702
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15473144
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14754793
81ER_23166858_ChIP-Seq_MCF-7_Human1.14064480
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13155691
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12893096
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12820691
85* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11981026
86REST_21632747_ChIP-Seq_MESCs_Mouse1.11271787
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10447942
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10243883
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.10089794
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09396213
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08553997
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.07740325
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.07583263
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05930862
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05796794
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05718892
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04022132
98* FOXP1_21924763_ChIP-Seq_HESCs_Human1.03733032
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03654119
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03155093
101KDM5A_27292631_Chip-Seq_BREAST_Human1.02892915
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02778235
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02442674
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02162415
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02086527
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01980703
107PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01500388
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00222175
109CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99998588
110P300_19829295_ChIP-Seq_ESCs_Human0.99776194
111THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99132384
112ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99030166
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98326895
114PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97984920
115ZNF274_21170338_ChIP-Seq_K562_Hela0.97848975
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97528975
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96114873
118TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95442538
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94373234
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93647464
121IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92927877
122ERG_20517297_ChIP-Seq_VCAP_Human0.92901775
123TP53_22573176_ChIP-Seq_HFKS_Human0.92357034
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91372538
125* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91227083
126YY1_22570637_ChIP-Seq_MALME-3M_Human0.89495350
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89316137
128SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88807348
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88484786
130RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88227031
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.87778642
132CTCF_26484167_Chip-Seq_Bcells_Mouse0.87731527
133RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87537626
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87525830
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86857313
136* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86460541
137NANOG_20526341_ChIP-Seq_ESCs_Human0.85561666
138TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85410554
139STAT1_20625510_ChIP-Seq_HELA_Human0.85365093
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84560586
141NANOG_19829295_ChIP-Seq_ESCs_Human0.83494559
142SOX2_19829295_ChIP-Seq_ESCs_Human0.83494559
143SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82806090
144* ELK1_22589737_ChIP-Seq_MCF10A_Human0.82430338
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81880181
146SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81839465
147MYC_19829295_ChIP-Seq_ESCs_Human0.81617344
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81601728
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81397583
150RXR_22158963_ChIP-Seq_LIVER_Mouse0.80892268
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80789582
152TAF2_19829295_ChIP-Seq_ESCs_Human0.80003931
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79979162
154* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79821961
155NCOR_22424771_ChIP-Seq_293T_Human0.77117071
156SOX2_22085726_ChIP-Seq_NPCs_Mouse0.76407084
157EGR1_23403033_ChIP-Seq_LIVER_Mouse0.75618041
158POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75520044
159EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74579590
160CTCF_20526341_ChIP-Seq_ESCs_Human0.74514111
161ELF1_20517297_ChIP-Seq_JURKAT_Human0.74280406
162AR_20517297_ChIP-Seq_VCAP_Human0.73947042
163SA1_27219007_Chip-Seq_Bcells_Human0.73247652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.40983193
2MP0003646_muscle_fatigue3.70691847
3MP0000751_myopathy3.25163701
4MP0003880_abnormal_central_pattern3.05912803
5MP0000749_muscle_degeneration2.86852369
6MP0003011_delayed_dark_adaptation2.85106945
7MP0006292_abnormal_olfactory_placode2.76402335
8MP0004036_abnormal_muscle_relaxation2.74504214
9MP0001529_abnormal_vocalization2.72126621
10MP0006036_abnormal_mitochondrial_physio2.71737615
11MP0004215_abnormal_myocardial_fiber2.61041837
12MP0004084_abnormal_cardiac_muscle2.56566517
13MP0010030_abnormal_orbit_morphology2.50266027
14MP0002938_white_spotting2.42062040
15MP0002822_catalepsy2.36394432
16MP0006072_abnormal_retinal_apoptosis2.25521286
17MP0005330_cardiomyopathy2.23872216
18MP0001905_abnormal_dopamine_level2.10711378
19MP0004145_abnormal_muscle_electrophysio2.07594682
20MP0006276_abnormal_autonomic_nervous1.93584484
21MP0004142_abnormal_muscle_tone1.90007927
22MP0004043_abnormal_pH_regulation1.89359191
23MP0003137_abnormal_impulse_conducting1.88932706
24MP0009379_abnormal_foot_pigmentation1.88120508
25MP0002736_abnormal_nociception_after1.84288857
26MP0003806_abnormal_nucleotide_metabolis1.83125379
27MP0000566_synostosis1.83122058
28MP0002972_abnormal_cardiac_muscle1.77079796
29MP0008995_early_reproductive_senescence1.76309229
30MP0003195_calcinosis1.73675679
31MP0002277_abnormal_respiratory_mucosa1.73174788
32MP0008058_abnormal_DNA_repair1.69971056
33MP0009046_muscle_twitch1.67951800
34MP0002064_seizures1.67040194
35MP0009745_abnormal_behavioral_response1.66433991
36MP0005620_abnormal_muscle_contractility1.64369659
37MP0002272_abnormal_nervous_system1.63200366
38* MP0006035_abnormal_mitochondrial_morpho1.58918590
39MP0003786_premature_aging1.58788956
40MP0004484_altered_response_of1.58118853
41MP0005084_abnormal_gallbladder_morpholo1.57860035
42MP0002332_abnormal_exercise_endurance1.57330762
43MP0001440_abnormal_grooming_behavior1.55841352
44MP0003718_maternal_effect1.52984258
45MP0001968_abnormal_touch/_nociception1.52468487
46MP0004133_heterotaxia1.52430641
47MP0008875_abnormal_xenobiotic_pharmacok1.46611400
48MP0002106_abnormal_muscle_physiology1.43846525
49MP0004147_increased_porphyrin_level1.43635511
50MP0005332_abnormal_amino_acid1.41747121
51MP0000747_muscle_weakness1.37795478
52MP0005253_abnormal_eye_physiology1.36033973
53MP0001485_abnormal_pinna_reflex1.33342309
54MP0004085_abnormal_heartbeat1.33168021
55MP0000750_abnormal_muscle_regeneration1.32949612
56MP0003635_abnormal_synaptic_transmissio1.32716611
57MP0002653_abnormal_ependyma_morphology1.32491918
58MP0004087_abnormal_muscle_fiber1.30357790
59MP0003186_abnormal_redox_activity1.29660580
60MP0008775_abnormal_heart_ventricle1.28643826
61MP0002876_abnormal_thyroid_physiology1.28226051
62MP0002139_abnormal_hepatobiliary_system1.27442106
63MP0005386_behavior/neurological_phenoty1.24811399
64MP0004924_abnormal_behavior1.24811399
65MP0005385_cardiovascular_system_phenoty1.23712250
66MP0001544_abnormal_cardiovascular_syste1.23712250
67MP0005646_abnormal_pituitary_gland1.23631579
68MP0005360_urolithiasis1.21530189
69MP0005369_muscle_phenotype1.21137238
70MP0000920_abnormal_myelination1.20365629
71MP0005535_abnormal_body_temperature1.19719631
72MP0004019_abnormal_vitamin_homeostasis1.19694686
73MP0003329_amyloid_beta_deposits1.19590247
74MP0002163_abnormal_gland_morphology1.19503051
75MP0002572_abnormal_emotion/affect_behav1.18595925
76MP0004130_abnormal_muscle_cell1.17543950
77MP0001984_abnormal_olfaction1.16264040
78MP0000631_abnormal_neuroendocrine_gland1.15906710
79MP0005379_endocrine/exocrine_gland_phen1.15541014
80MP0002735_abnormal_chemical_nociception1.15246495
81MP0005085_abnormal_gallbladder_physiolo1.13300831
82MP0006138_congestive_heart_failure1.11675169
83MP0003938_abnormal_ear_development1.11563717
84MP0008789_abnormal_olfactory_epithelium1.11321945
85MP0005451_abnormal_body_composition1.11141198
86MP0003136_yellow_coat_color1.10517152
87MP0001501_abnormal_sleep_pattern1.09522594
88MP0005410_abnormal_fertilization1.08853506
89MP0000759_abnormal_skeletal_muscle1.07839035
90MP0002067_abnormal_sensory_capabilities1.06082967
91MP0001970_abnormal_pain_threshold1.05303150
92MP0003950_abnormal_plasma_membrane1.05130550
93MP0001727_abnormal_embryo_implantation1.04959963
94MP0001486_abnormal_startle_reflex1.04946070
95MP0005075_abnormal_melanosome_morpholog1.04422116
96MP0003878_abnormal_ear_physiology1.04386740
97MP0005377_hearing/vestibular/ear_phenot1.04386740
98MP0002269_muscular_atrophy1.03810363
99MP0002909_abnormal_adrenal_gland1.03605681
100MP0000230_abnormal_systemic_arterial1.03125378
101MP0002234_abnormal_pharynx_morphology1.02215985
102MP0003283_abnormal_digestive_organ1.02208443
103MP0002734_abnormal_mechanical_nocicepti1.02045766
104MP0005083_abnormal_biliary_tract1.01788171
105MP0000013_abnormal_adipose_tissue1.01154167
106MP0005165_increased_susceptibility_to0.99271932
107MP0005584_abnormal_enzyme/coenzyme_acti0.98844775
108MP0002063_abnormal_learning/memory/cond0.97884972
109MP0004270_analgesia0.97136583
110MP0001293_anophthalmia0.96879597
111MP0002102_abnormal_ear_morphology0.95591320
112MP0010386_abnormal_urinary_bladder0.95280657
113MP0005266_abnormal_metabolism0.94359251
114MP0003693_abnormal_embryo_hatching0.94092909
115MP0000026_abnormal_inner_ear0.93506897
116MP0002090_abnormal_vision0.92858517
117MP0009697_abnormal_copulation0.91103938
118MP0005636_abnormal_mineral_homeostasis0.91058879
119MP0005408_hypopigmentation0.90672002
120MP0002733_abnormal_thermal_nociception0.89832971
121MP0008872_abnormal_physiological_respon0.86964128
122MP0002095_abnormal_skin_pigmentation0.86503550
123MP0004859_abnormal_synaptic_plasticity0.84821796
124MP0005171_absent_coat_pigmentation0.81384926
125MP0001963_abnormal_hearing_physiology0.80262916
126MP0002638_abnormal_pupillary_reflex0.78735404
127MP0008932_abnormal_embryonic_tissue0.78266425
128MP0002557_abnormal_social/conspecific_i0.77464821
129MP0005394_taste/olfaction_phenotype0.77363284
130MP0005499_abnormal_olfactory_system0.77363284
131MP0001664_abnormal_digestion0.77047204
132MP0000372_irregular_coat_pigmentation0.76505198
133MP0002066_abnormal_motor_capabilities/c0.76300630
134MP0002229_neurodegeneration0.76259711
135MP0004510_myositis0.74113484
136MP0005423_abnormal_somatic_nervous0.71514360
137MP0005376_homeostasis/metabolism_phenot0.71429421
138MP0001765_abnormal_ion_homeostasis0.71356432
139MP0000343_altered_response_to0.70706332
140MP0001346_abnormal_lacrimal_gland0.70605850
141MP0001764_abnormal_homeostasis0.70269731
142MP0004885_abnormal_endolymph0.69956050
143MP0000049_abnormal_middle_ear0.69820279
144MP0002210_abnormal_sex_determination0.69804544
145MP0003690_abnormal_glial_cell0.69162305
146MP0001756_abnormal_urination0.68188178
147MP0002127_abnormal_cardiovascular_syste0.68161638
148MP0003638_abnormal_response/metabolism_0.66165966
149MP0005551_abnormal_eye_electrophysiolog0.65688792
150MP0002751_abnormal_autonomic_nervous0.65052928
151MP0004742_abnormal_vestibular_system0.64315766
152MP0005645_abnormal_hypothalamus_physiol0.62868754

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.36067796
2Abnormal mitochondria in muscle tissue (HP:0008316)6.83356571
3Acute encephalopathy (HP:0006846)6.35210663
4Mitochondrial inheritance (HP:0001427)6.32003432
5Progressive macrocephaly (HP:0004481)6.19931019
6Hepatocellular necrosis (HP:0001404)5.55593036
7Increased CSF lactate (HP:0002490)5.42801023
8Hepatic necrosis (HP:0002605)5.23335534
9Cerebral edema (HP:0002181)4.88498274
10Abnormal number of erythroid precursors (HP:0012131)4.62192418
11Abnormality of cells of the erythroid lineage (HP:0012130)4.36113811
12Increased hepatocellular lipid droplets (HP:0006565)4.33587720
13Lipid accumulation in hepatocytes (HP:0006561)4.18328336
14Increased intramyocellular lipid droplets (HP:0012240)4.10981238
15Respiratory failure (HP:0002878)4.05523238
16Lactic acidosis (HP:0003128)4.00343375
17Reticulocytopenia (HP:0001896)3.91225647
18Renal Fanconi syndrome (HP:0001994)3.90227862
19Exercise intolerance (HP:0003546)3.89083864
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.84312738
21Increased muscle lipid content (HP:0009058)3.83477630
22Optic disc pallor (HP:0000543)3.79253561
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.69527827
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.69527827
25Leukodystrophy (HP:0002415)3.65293123
26Muscle hypertrophy of the lower extremities (HP:0008968)3.64790211
27Increased serum pyruvate (HP:0003542)3.64105343
28Abnormality of glycolysis (HP:0004366)3.64105343
29Calf muscle hypertrophy (HP:0008981)3.61680170
30Sudden death (HP:0001699)3.59282859
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.36465013
32Macrocytic anemia (HP:0001972)3.32915711
33Increased serum lactate (HP:0002151)3.23515215
34Pheochromocytoma (HP:0002666)3.20732955
35Neuroendocrine neoplasm (HP:0100634)3.16807649
36Exercise-induced myalgia (HP:0003738)3.08548890
373-Methylglutaconic aciduria (HP:0003535)2.94860972
38Palpitations (HP:0001962)2.93574692
39Lethargy (HP:0001254)2.86033114
40Exercise-induced muscle cramps (HP:0003710)2.71255990
41Abnormality of renal resorption (HP:0011038)2.70064869
42Exertional dyspnea (HP:0002875)2.67666593
43Abnormality of urine glucose concentration (HP:0011016)2.66199216
44Glycosuria (HP:0003076)2.66199216
45Abnormality of the calf musculature (HP:0001430)2.63752569
46Muscle fiber splitting (HP:0003555)2.63589450
47Myoglobinuria (HP:0002913)2.62012552
48CNS demyelination (HP:0007305)2.58178985
49Respiratory difficulties (HP:0002880)2.56657615
50Ventricular tachycardia (HP:0004756)2.56460690
51Type I transferrin isoform profile (HP:0003642)2.55172200
52Aplastic anemia (HP:0001915)2.50451519
53X-linked dominant inheritance (HP:0001423)2.50315690
54Dicarboxylic aciduria (HP:0003215)2.47783513
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47783513
56Oral leukoplakia (HP:0002745)2.46734221
57Congenital, generalized hypertrichosis (HP:0004540)2.46422837
58Conjunctival hamartoma (HP:0100780)2.35027652
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31887049
60Esophageal neoplasm (HP:0100751)2.29830511
61Neoplasm of head and neck (HP:0012288)2.29830511
62Pancreatic fibrosis (HP:0100732)2.29587969
63Myokymia (HP:0002411)2.28064145
64Myotonia (HP:0002486)2.27546450
65Syncope (HP:0001279)2.26106746
66Vomiting (HP:0002013)2.25300075
67Atrial fibrillation (HP:0005110)2.24350566
68Hyperphosphaturia (HP:0003109)2.23885218
69Emotional lability (HP:0000712)2.23634315
70Methylmalonic aciduria (HP:0012120)2.23168953
71Abnormality of fatty-acid metabolism (HP:0004359)2.20622827
72Rhabdomyolysis (HP:0003201)2.19630021
73Lipoatrophy (HP:0100578)2.17517305
74Ketoacidosis (HP:0001993)2.17296015
75Pallor (HP:0000980)2.15359566
76Cerebral hemorrhage (HP:0001342)2.12324544
77Muscle stiffness (HP:0003552)2.12263002
78Primary atrial arrhythmia (HP:0001692)2.12010229
79Supraventricular tachycardia (HP:0004755)2.11998920
80Pancreatic cysts (HP:0001737)2.11026338
81True hermaphroditism (HP:0010459)2.09593732
82Generalized aminoaciduria (HP:0002909)2.08830288
83Prolonged QT interval (HP:0001657)2.07255104
84Septo-optic dysplasia (HP:0100842)2.05952428
85EMG: myopathic abnormalities (HP:0003458)2.05849736
86Colon cancer (HP:0003003)2.04840472
87Supraventricular arrhythmia (HP:0005115)2.04208580
88Focal motor seizures (HP:0011153)2.02869482
89Hyperglycinemia (HP:0002154)2.01290073
90Methylmalonic acidemia (HP:0002912)2.00966171
91Dilated cardiomyopathy (HP:0001644)1.98980423
92Testicular atrophy (HP:0000029)1.98753067
93Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92746764
94Microvesicular hepatic steatosis (HP:0001414)1.92243198
95Abnormal urine phosphate concentration (HP:0012599)1.90809972
96Ragged-red muscle fibers (HP:0003200)1.90468743
97Concave nail (HP:0001598)1.90208739
98Ketosis (HP:0001946)1.86034454
99Left ventricular hypertrophy (HP:0001712)1.84456716
100Degeneration of anterior horn cells (HP:0002398)1.83741330
101Abnormality of the anterior horn cell (HP:0006802)1.83741330
102Molar tooth sign on MRI (HP:0002419)1.83261926
103Abnormality of midbrain morphology (HP:0002418)1.83261926
104Sclerocornea (HP:0000647)1.83136947
105Metabolic acidosis (HP:0001942)1.80633847
106Abnormal protein glycosylation (HP:0012346)1.79021993
107Abnormal glycosylation (HP:0012345)1.79021993
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79021993
109Abnormal protein N-linked glycosylation (HP:0012347)1.79021993
110Pancytopenia (HP:0001876)1.78162858
111Hyperventilation (HP:0002883)1.76837954
112Gliosis (HP:0002171)1.76550540
113Renal tubular dysfunction (HP:0000124)1.75913487
114Proximal tubulopathy (HP:0000114)1.73476962
115Partial duplication of thumb phalanx (HP:0009944)1.73442320
116Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73397526
117Poor suck (HP:0002033)1.72489275
118Abnormal pupillary function (HP:0007686)1.71241875
119Hypoplastic left heart (HP:0004383)1.71093914
120Hyporeflexia of lower limbs (HP:0002600)1.71014649
121Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70849887
122Parakeratosis (HP:0001036)1.70645677
123Rough bone trabeculation (HP:0100670)1.68667957
124Blindness (HP:0000618)1.67427153
125Hypoglycemic coma (HP:0001325)1.66808229
126Medial flaring of the eyebrow (HP:0010747)1.65320446
127Absent septum pellucidum (HP:0001331)1.65272103
128Abnormality of placental membranes (HP:0011409)1.64461784
129Amniotic constriction ring (HP:0009775)1.64461784
130Nephronophthisis (HP:0000090)1.64024642
131Cerebral hypomyelination (HP:0006808)1.63753172
132Nausea (HP:0002018)1.62198570
133Hypothermia (HP:0002045)1.61322787
134Abnormality of the labia minora (HP:0012880)1.60879552
135Abnormal respiratory motile cilium physiology (HP:0012261)1.58423503
136Anxiety (HP:0000739)1.57614059
137Sparse eyelashes (HP:0000653)1.56799056
138Oligomenorrhea (HP:0000876)1.56174302
139Hyperglycinuria (HP:0003108)1.55777674
140Partial duplication of the phalanx of hand (HP:0009999)1.54615187
141Progressive external ophthalmoplegia (HP:0000590)1.53664257
142Reduced antithrombin III activity (HP:0001976)1.53314694
143Cholecystitis (HP:0001082)1.52775339
144Abnormal gallbladder physiology (HP:0012438)1.52775339
145Abnormality of the vocal cords (HP:0008777)1.52126414
146Hyperalaninemia (HP:0003348)1.52110939
147Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.52110939
148Abnormal ciliary motility (HP:0012262)1.49764081
149Delayed CNS myelination (HP:0002188)1.47424103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.53299258
2MYLK3.78525717
3MAP3K123.41892131
4NME13.32084888
5BUB13.14784352
6BCKDK2.88843706
7OBSCN2.82580492
8MUSK2.78542463
9STK392.68411362
10ZAK2.51401779
11NME22.42692669
12ARAF2.38452982
13CASK2.37618755
14WNK42.30133296
15OXSR12.27749245
16GRK72.20668831
17TESK22.17396251
18PHKG22.09827640
19PHKG12.09827640
20PDK31.88400532
21PDK41.88400532
22DYRK21.83784306
23PIK3CA1.79333585
24LMTK21.76163607
25TESK11.73438565
26TTN1.72820568
27MAP4K21.64745053
28MST41.64009544
29CDC71.63781212
30STK161.60296091
31GRK51.60156932
32PINK11.57899529
33PBK1.51249384
34CAMK2D1.50248697
35MAP2K71.48519933
36PDK21.42442263
37SRPK11.30387557
38MST1R1.29583779
39NUAK11.27737828
40PNCK1.27395730
41NEK11.26628674
42TAF11.24568572
43DAPK31.23155254
44MAPKAPK51.22179572
45EPHA41.20428506
46CAMK2A1.18980689
47INSRR1.18518245
48LIMK11.16820604
49CDK191.15164756
50CAMK2G1.14119866
51TNIK1.13276628
52BCR1.11681551
53MAP3K41.10344647
54ADRBK21.10024771
55GRK11.09426603
56PKN11.09235879
57CAMK2B1.08540948
58PLK31.03986545
59ABL20.98543612
60MAP2K40.96744899
61BMPR20.96589545
62ROCK20.95245839
63ILK0.92325014
64WNK30.90538247
65BRAF0.87850522
66TXK0.87709267
67PRKCE0.86939215
68LRRK20.85265818
69PIM20.85063231
70RIPK40.83487726
71RPS6KA50.81907278
72PLK20.81535244
73PASK0.81262049
74CCNB10.80740730
75AURKA0.80623346
76ADRBK10.79396253
77NTRK30.78102171
78MAPKAPK30.77637460
79MAPK120.76530646
80EPHB20.74774364
81PRKACA0.73959709
82TIE10.73557622
83PAK30.73075368
84PIK3CG0.71563538
85PTK2B0.70549779
86CSNK1G20.67778951
87CSNK2A20.66966421
88PRKCI0.66871974
89CSNK2A10.66541624
90CSNK1G10.66469956
91ROCK10.63130432
92AURKB0.62285359
93PLK10.61865643
94PLK40.61371953
95PRKCQ0.59247249
96DYRK30.58432900
97PRKCG0.57590349
98WNK10.53752677
99TTK0.53413148
100PRKG20.52859258
101FGR0.52480555
102STK40.51918555
103FGFR20.51260768
104BMPR1B0.50377205
105UHMK10.49938325
106CHEK20.49424424
107CDK80.48875668
108BRSK10.48328912
109NTRK10.47492070
110MET0.45530181
111STK240.45451637
112PAK10.43896890
113KDR0.43339306
114CSNK1A10.42760412
115MAP3K110.41384866
116VRK10.40524313
117CAMK10.40318626
118STK38L0.40210295
119PRKCA0.39727349
120PRKD10.39147675
121CDK50.37928489
122MINK10.37277883
123ERBB40.36858697
124PRKACB0.36790974
125CSNK1A1L0.36585925
126SGK2230.35440466
127SGK4940.35440466
128NEK60.34091534
129ATR0.33635012
130CSNK1G30.33548832
131PRKACG0.33381806
132MAPK150.32706742
133PDPK10.32466424
134IRAK20.32103897
135GRK60.31918708
136PRPF4B0.30991325
137MAPK130.30316840
138MAP2K60.30039103
139TRIM280.29773990
140WEE10.29029213
141PRKCD0.28570780
142PRKG10.28281940
143TLK10.27795601
144DAPK10.26035066
145MAP2K10.25683801

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.31500477
2Parkinsons disease_Homo sapiens_hsa050125.35181808
3Alzheimers disease_Homo sapiens_hsa050104.12690241
4Huntingtons disease_Homo sapiens_hsa050163.57442394
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.45755208
6Cardiac muscle contraction_Homo sapiens_hsa042603.31970373
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.11005194
8Propanoate metabolism_Homo sapiens_hsa006402.17977228
9Fatty acid elongation_Homo sapiens_hsa000622.17107802
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14605315
11Ribosome_Homo sapiens_hsa030102.03551565
12Collecting duct acid secretion_Homo sapiens_hsa049662.01488870
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91428456
14Proteasome_Homo sapiens_hsa030501.90295731
15Pyruvate metabolism_Homo sapiens_hsa006201.83768011
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78662547
17Sulfur metabolism_Homo sapiens_hsa009201.75327428
18DNA replication_Homo sapiens_hsa030301.72449088
19Mismatch repair_Homo sapiens_hsa034301.68304872
20Butanoate metabolism_Homo sapiens_hsa006501.63552436
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58890226
22Homologous recombination_Homo sapiens_hsa034401.57055807
23Protein export_Homo sapiens_hsa030601.50742195
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.45809197
25Carbon metabolism_Homo sapiens_hsa012001.38291025
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36563665
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34228135
28Fatty acid degradation_Homo sapiens_hsa000711.33027217
29Spliceosome_Homo sapiens_hsa030401.23236347
30Base excision repair_Homo sapiens_hsa034101.18482789
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17589633
32Fatty acid metabolism_Homo sapiens_hsa012121.17097887
33Vibrio cholerae infection_Homo sapiens_hsa051101.16232192
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11048354
35Peroxisome_Homo sapiens_hsa041461.08017735
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06771691
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01329087
38Phenylalanine metabolism_Homo sapiens_hsa003600.99547150
39Nucleotide excision repair_Homo sapiens_hsa034200.97372968
40Nicotine addiction_Homo sapiens_hsa050330.90147401
41Synaptic vesicle cycle_Homo sapiens_hsa047210.89719402
42Tyrosine metabolism_Homo sapiens_hsa003500.89307810
43RNA degradation_Homo sapiens_hsa030180.88942714
44* Metabolic pathways_Homo sapiens_hsa011000.88627427
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.84700080
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82893937
47One carbon pool by folate_Homo sapiens_hsa006700.81679070
48Dilated cardiomyopathy_Homo sapiens_hsa054140.78584271
49Arginine and proline metabolism_Homo sapiens_hsa003300.77135925
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76839762
51beta-Alanine metabolism_Homo sapiens_hsa004100.76699311
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75024220
53RNA polymerase_Homo sapiens_hsa030200.74674386
54Rheumatoid arthritis_Homo sapiens_hsa053230.72854208
55Phototransduction_Homo sapiens_hsa047440.72043108
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68956898
57Nitrogen metabolism_Homo sapiens_hsa009100.68776432
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67117943
59Fanconi anemia pathway_Homo sapiens_hsa034600.66894261
60Glutathione metabolism_Homo sapiens_hsa004800.66795421
61Tryptophan metabolism_Homo sapiens_hsa003800.66792605
62Basal transcription factors_Homo sapiens_hsa030220.65570418
63RNA transport_Homo sapiens_hsa030130.64305267
64GABAergic synapse_Homo sapiens_hsa047270.62588013
65Histidine metabolism_Homo sapiens_hsa003400.61505931
66Chemical carcinogenesis_Homo sapiens_hsa052040.61088464
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61038625
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58982598
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.58240804
70PPAR signaling pathway_Homo sapiens_hsa033200.57845651
71Taste transduction_Homo sapiens_hsa047420.53287986
72Steroid biosynthesis_Homo sapiens_hsa001000.53286690
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.52693115
74Biosynthesis of amino acids_Homo sapiens_hsa012300.51260617
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48978297
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48497798
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47972152
78Serotonergic synapse_Homo sapiens_hsa047260.47679460
79Linoleic acid metabolism_Homo sapiens_hsa005910.47675567
80Arachidonic acid metabolism_Homo sapiens_hsa005900.46323037
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45708471
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44838497
83Mineral absorption_Homo sapiens_hsa049780.42575524
84Calcium signaling pathway_Homo sapiens_hsa040200.41755089
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41270764
86Starch and sucrose metabolism_Homo sapiens_hsa005000.40667839
87Ether lipid metabolism_Homo sapiens_hsa005650.40100411
88Sulfur relay system_Homo sapiens_hsa041220.39314984
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39178594
90Morphine addiction_Homo sapiens_hsa050320.38615648
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38448132
92Fructose and mannose metabolism_Homo sapiens_hsa000510.36668855
93Vitamin B6 metabolism_Homo sapiens_hsa007500.36080951
94Arginine biosynthesis_Homo sapiens_hsa002200.35296095
95Systemic lupus erythematosus_Homo sapiens_hsa053220.35047131
96Selenocompound metabolism_Homo sapiens_hsa004500.33713067
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33479769
98Circadian entrainment_Homo sapiens_hsa047130.33197506
99N-Glycan biosynthesis_Homo sapiens_hsa005100.32759762
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32322699
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32022789
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31915205
103Vitamin digestion and absorption_Homo sapiens_hsa049770.30846939
104Phagosome_Homo sapiens_hsa041450.30080186
105Gastric acid secretion_Homo sapiens_hsa049710.29408932
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29343256
107Salivary secretion_Homo sapiens_hsa049700.28372087
108Glutamatergic synapse_Homo sapiens_hsa047240.27704101
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.26994198
110Folate biosynthesis_Homo sapiens_hsa007900.26056994
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25010608
112Pentose phosphate pathway_Homo sapiens_hsa000300.24096482
113Fat digestion and absorption_Homo sapiens_hsa049750.24043312
114Primary immunodeficiency_Homo sapiens_hsa053400.23800216
115Renin secretion_Homo sapiens_hsa049240.23471000
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23030653
117Olfactory transduction_Homo sapiens_hsa047400.22923630
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.22780445
119Pancreatic secretion_Homo sapiens_hsa049720.22762859
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20220591
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.20132115
122Retinol metabolism_Homo sapiens_hsa008300.18829585
123Amphetamine addiction_Homo sapiens_hsa050310.18823117
124Caffeine metabolism_Homo sapiens_hsa002320.18173748
125Pyrimidine metabolism_Homo sapiens_hsa002400.17508910
126Galactose metabolism_Homo sapiens_hsa000520.17470706
127Purine metabolism_Homo sapiens_hsa002300.16658150
128Regulation of autophagy_Homo sapiens_hsa041400.16319565
129Glycerolipid metabolism_Homo sapiens_hsa005610.16057790

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