NDUFA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.62215994
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.51977806
3ATP synthesis coupled proton transport (GO:0015986)9.51977806
4* respiratory electron transport chain (GO:0022904)8.51991749
5* electron transport chain (GO:0022900)8.30612074
6chaperone-mediated protein transport (GO:0072321)5.83982453
7protein neddylation (GO:0045116)5.69249645
8ribosomal small subunit biogenesis (GO:0042274)5.28040598
9viral transcription (GO:0019083)5.12433345
10ATP biosynthetic process (GO:0006754)5.00970864
11hydrogen ion transmembrane transport (GO:1902600)4.95183743
12protein complex biogenesis (GO:0070271)4.95176888
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.93839916
14translational termination (GO:0006415)4.85981186
15purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.84944331
16purine nucleoside triphosphate biosynthetic process (GO:0009145)4.75884089
17cotranslational protein targeting to membrane (GO:0006613)4.67434343
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.66095141
19NADH dehydrogenase complex assembly (GO:0010257)4.66095141
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.66095141
21inner mitochondrial membrane organization (GO:0007007)4.65818270
22protein targeting to ER (GO:0045047)4.65787089
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.57580475
24protein localization to endoplasmic reticulum (GO:0070972)4.47428808
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.45907768
26mitochondrial respiratory chain complex assembly (GO:0033108)4.43600069
27proton transport (GO:0015992)4.35845385
28GTP biosynthetic process (GO:0006183)4.28851466
29hydrogen transport (GO:0006818)4.27334814
30ribonucleoside triphosphate biosynthetic process (GO:0009201)4.15678774
31axon ensheathment in central nervous system (GO:0032291)4.09770274
32central nervous system myelination (GO:0022010)4.09770274
33viral life cycle (GO:0019058)3.86467766
34translational elongation (GO:0006414)3.85272321
35oxidative phosphorylation (GO:0006119)3.80949663
36cellular protein complex disassembly (GO:0043624)3.79551117
37cellular component biogenesis (GO:0044085)3.65965457
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60768292
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.60732161
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.60732161
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59680723
42rRNA modification (GO:0000154)3.57931939
43nuclear-transcribed mRNA catabolic process (GO:0000956)3.52546845
44nucleoside triphosphate biosynthetic process (GO:0009142)3.52209790
45ribosomal small subunit assembly (GO:0000028)3.50458961
46UTP biosynthetic process (GO:0006228)3.45363577
47regulation of mitochondrial translation (GO:0070129)3.42789932
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40805798
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35522313
50protein targeting to mitochondrion (GO:0006626)3.35238651
51DNA deamination (GO:0045006)3.33935694
52mRNA catabolic process (GO:0006402)3.33556686
53translation (GO:0006412)3.32391277
54ribosomal large subunit biogenesis (GO:0042273)3.30631956
55respiratory chain complex IV assembly (GO:0008535)3.30037513
56mitochondrial transport (GO:0006839)3.27269994
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27262526
58negative regulation of ligase activity (GO:0051352)3.27262526
59establishment of protein localization to mitochondrion (GO:0072655)3.27071664
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23129711
61regulation of oxidative phosphorylation (GO:0002082)3.22898549
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21682092
63protein complex disassembly (GO:0043241)3.20126843
64fatty acid elongation (GO:0030497)3.19658288
65ubiquinone biosynthetic process (GO:0006744)3.19393075
66quinone biosynthetic process (GO:1901663)3.19393075
67ribonucleoprotein complex biogenesis (GO:0022613)3.19076899
68water-soluble vitamin biosynthetic process (GO:0042364)3.17886566
69pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17568689
70sequestering of actin monomers (GO:0042989)3.16638887
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15984996
72pseudouridine synthesis (GO:0001522)3.12337314
73protein targeting to membrane (GO:0006612)3.11330531
74cardiac ventricle formation (GO:0003211)3.10748203
75negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.10635207
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10183022
77protein localization to mitochondrion (GO:0070585)3.09926009
78translational initiation (GO:0006413)3.08252674
79UTP metabolic process (GO:0046051)3.07054480
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06317816
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06317816
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06317816
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06173996
84RNA catabolic process (GO:0006401)3.04958052
85substantia nigra development (GO:0021762)3.04733546
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04672465
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04672465
88macromolecular complex disassembly (GO:0032984)3.04628140
89proteasome assembly (GO:0043248)3.04275253
90cytochrome complex assembly (GO:0017004)3.00929885
91rRNA processing (GO:0006364)3.00116343
92ubiquinone metabolic process (GO:0006743)2.98728836
93intracellular protein transmembrane import (GO:0044743)2.97335103
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94222683
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.94222683
96spliceosomal snRNP assembly (GO:0000387)2.93542308
977-methylguanosine mRNA capping (GO:0006370)2.93415267
98* generation of precursor metabolites and energy (GO:0006091)2.90863327
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90626113
100cardiac chamber formation (GO:0003207)2.90384008
101rRNA metabolic process (GO:0016072)2.90348045
102signal transduction involved in cell cycle checkpoint (GO:0072395)2.89794774
103aerobic respiration (GO:0009060)2.87346627
104RNA capping (GO:0036260)2.85212596
1057-methylguanosine RNA capping (GO:0009452)2.85212596
106dopamine transport (GO:0015872)2.84342472
107guanosine-containing compound biosynthetic process (GO:1901070)2.79468061
108aldehyde catabolic process (GO:0046185)2.76069030
109maturation of SSU-rRNA (GO:0030490)2.69971871
110energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.69190483
111ATP hydrolysis coupled proton transport (GO:0015991)2.69190483
112purine ribonucleoside biosynthetic process (GO:0046129)2.69157773
113purine nucleoside biosynthetic process (GO:0042451)2.69157773
114nucleoside diphosphate phosphorylation (GO:0006165)2.68326698
115CTP biosynthetic process (GO:0006241)2.67105270
116CTP metabolic process (GO:0046036)2.67105270
117protein-cofactor linkage (GO:0018065)2.66146553
118dopamine biosynthetic process (GO:0042416)2.61945707
119regulation of catecholamine metabolic process (GO:0042069)2.61208345
120regulation of dopamine metabolic process (GO:0042053)2.61208345
121purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.53517308
122purine nucleoside monophosphate biosynthetic process (GO:0009127)2.53517308
123iron-sulfur cluster assembly (GO:0016226)2.53314133
124metallo-sulfur cluster assembly (GO:0031163)2.53314133
125cytidine deamination (GO:0009972)2.47251546
126cytidine metabolic process (GO:0046087)2.47251546
127cytidine catabolic process (GO:0006216)2.47251546
128regulation of cellular respiration (GO:0043457)2.46936416
129transcription elongation from RNA polymerase III promoter (GO:0006385)2.46768549
130termination of RNA polymerase III transcription (GO:0006386)2.46768549
131mitochondrion morphogenesis (GO:0070584)2.46561157
132negative regulation of protein localization to cell surface (GO:2000009)2.46114936
133secondary heart field specification (GO:0003139)2.44997847
134heart field specification (GO:0003128)2.44997847
135regulation of cell communication by electrical coupling (GO:0010649)2.44836573
136protein targeting (GO:0006605)2.43882831
137regulation of cellular amino acid metabolic process (GO:0006521)2.39818136
138mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.2129485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.74424599
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.33314443
3EZH2_22144423_ChIP-Seq_EOC_Human3.40647033
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31190481
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07111603
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.90547369
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.73617263
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53251291
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46483872
10VDR_22108803_ChIP-Seq_LS180_Human2.41709521
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40543718
12FOXP3_21729870_ChIP-Seq_TREG_Human2.32993485
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31984235
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27634692
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24660694
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23285737
17* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.16708318
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14796490
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.12257506
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.10776192
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09002794
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01255316
23* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.00339779
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97741022
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93104036
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.92777806
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88222070
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.84162757
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.82384364
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82182251
31GABP_19822575_ChIP-Seq_HepG2_Human1.80240848
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76305105
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73673911
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73518501
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71925201
36TAF15_26573619_Chip-Seq_HEK293_Human1.68035508
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63488289
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62096210
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60878889
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.59708929
41IGF1R_20145208_ChIP-Seq_DFB_Human1.59540434
42* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52386898
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52262178
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49881048
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49452382
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47873614
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47698194
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47583424
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.45864593
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44541307
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41918863
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41887081
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40388848
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40388848
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38090169
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.35260874
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35073889
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35027577
59GBX2_23144817_ChIP-Seq_PC3_Human1.33837361
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29403781
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.26873570
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26255542
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26010852
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.25330612
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22692474
66ZNF274_21170338_ChIP-Seq_K562_Hela1.21863560
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19706590
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19567774
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19417805
70* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18942663
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.18384625
72* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17496815
73MYC_18940864_ChIP-ChIP_HL60_Human1.16824786
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16666795
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16663602
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.14846203
77MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14733465
78DCP1A_22483619_ChIP-Seq_HELA_Human1.14637222
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12368791
80TP53_22573176_ChIP-Seq_HFKS_Human1.11778623
81* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11595438
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10336283
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09078929
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08280189
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06731370
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06230953
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04394277
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03986752
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03523710
90KDM5A_27292631_Chip-Seq_BREAST_Human1.02852950
91* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02842533
92STAT1_20625510_ChIP-Seq_HELA_Human1.02129145
93ER_23166858_ChIP-Seq_MCF-7_Human1.01089772
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00972296
95ELK1_19687146_ChIP-ChIP_HELA_Human1.00537749
96* SOX2_16153702_ChIP-ChIP_HESCs_Human0.99872735
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98783394
98ERG_20517297_ChIP-Seq_VCAP_Human0.98155652
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95269706
100* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94821972
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94384757
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94110215
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93781912
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93540994
105IRF1_19129219_ChIP-ChIP_H3396_Human0.93538485
106EWS_26573619_Chip-Seq_HEK293_Human0.92275255
107NANOG_20526341_ChIP-Seq_ESCs_Human0.91451106
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91349614
109* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90950551
110KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90015792
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89928535
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89699493
113FUS_26573619_Chip-Seq_HEK293_Human0.89496353
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89054537
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88494434
116TTF2_22483619_ChIP-Seq_HELA_Human0.88150510
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87353017
118VDR_23849224_ChIP-Seq_CD4+_Human0.87164813
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86410822
120RNF2_27304074_Chip-Seq_NSC_Mouse0.85999775
121NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84092068
122AR_20517297_ChIP-Seq_VCAP_Human0.83970521
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83884897
124* FOXP1_21924763_ChIP-Seq_HESCs_Human0.83866191
125PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83791905
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83782988
127* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83582492
128EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83334239
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82943327
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82912624
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82784904
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82730640
133P300_19829295_ChIP-Seq_ESCs_Human0.82193458
134REST_18959480_ChIP-ChIP_MESCs_Mouse0.82147513
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81291320
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81213888
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80855510
138* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80512721
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80506891
140NANOG_16153702_ChIP-ChIP_HESCs_Human0.80180964
141FOXA1_25329375_ChIP-Seq_VCAP_Human0.79039869
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79039869
143* YY1_22570637_ChIP-Seq_MALME-3M_Human0.78972932
144CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78229899
145* XRN2_22483619_ChIP-Seq_HELA_Human0.77299400
146* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77215152
147POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77148386
148RNF2_27304074_Chip-Seq_ESCs_Mouse0.77134792
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75078247
150MYCN_18555785_ChIP-Seq_MESCs_Mouse0.73098771
151EGR1_23403033_ChIP-Seq_LIVER_Mouse0.71163055
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.71106962
153E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.69993818
154NCOR_22424771_ChIP-Seq_293T_Human0.69980920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.08525522
2MP0003880_abnormal_central_pattern3.98558495
3MP0002837_dystrophic_cardiac_calcinosis3.67247496
4MP0001529_abnormal_vocalization3.47765271
5MP0006276_abnormal_autonomic_nervous2.83908222
6MP0001905_abnormal_dopamine_level2.72109738
7MP0004142_abnormal_muscle_tone2.48935967
8MP0008058_abnormal_DNA_repair2.35815628
9MP0006036_abnormal_mitochondrial_physio2.25106360
10MP0003136_yellow_coat_color2.14064635
11MP0000751_myopathy2.06031549
12MP0004145_abnormal_muscle_electrophysio2.01594409
13MP0001968_abnormal_touch/_nociception1.92859858
14MP0003646_muscle_fatigue1.89570319
15MP0002736_abnormal_nociception_after1.88774459
16MP0003137_abnormal_impulse_conducting1.88382271
17MP0002822_catalepsy1.80805715
18MP0002653_abnormal_ependyma_morphology1.80033274
19MP0002272_abnormal_nervous_system1.78652854
20MP0000920_abnormal_myelination1.74905888
21MP0010030_abnormal_orbit_morphology1.71488004
22MP0004742_abnormal_vestibular_system1.71371032
23MP0004043_abnormal_pH_regulation1.70086395
24MP0005423_abnormal_somatic_nervous1.69750829
25MP0001485_abnormal_pinna_reflex1.69189674
26MP0002064_seizures1.68526678
27MP0006035_abnormal_mitochondrial_morpho1.66941636
28MP0000749_muscle_degeneration1.64300949
29MP0002638_abnormal_pupillary_reflex1.62822103
30MP0009745_abnormal_behavioral_response1.61302141
31MP0005409_darkened_coat_color1.61203054
32MP0005645_abnormal_hypothalamus_physiol1.60768435
33MP0004215_abnormal_myocardial_fiber1.59606962
34MP0008789_abnormal_olfactory_epithelium1.57403654
35MP0008995_early_reproductive_senescence1.55645341
36MP0004036_abnormal_muscle_relaxation1.51859302
37MP0001984_abnormal_olfaction1.50121214
38MP0003786_premature_aging1.49839721
39MP0001440_abnormal_grooming_behavior1.49813033
40MP0005379_endocrine/exocrine_gland_phen1.48144377
41MP0006072_abnormal_retinal_apoptosis1.43386418
42MP0001764_abnormal_homeostasis1.42753783
43MP0004147_increased_porphyrin_level1.40382544
44MP0004957_abnormal_blastocyst_morpholog1.37481821
45MP0001970_abnormal_pain_threshold1.36030303
46MP0002163_abnormal_gland_morphology1.35990988
47MP0001486_abnormal_startle_reflex1.35867845
48MP0003693_abnormal_embryo_hatching1.34374869
49MP0000631_abnormal_neuroendocrine_gland1.33954070
50MP0002572_abnormal_emotion/affect_behav1.28518829
51MP0005330_cardiomyopathy1.27202958
52MP0003011_delayed_dark_adaptation1.27115886
53MP0002067_abnormal_sensory_capabilities1.27044911
54MP0003195_calcinosis1.26439982
55MP0001727_abnormal_embryo_implantation1.26265928
56MP0005408_hypopigmentation1.25100471
57MP0002734_abnormal_mechanical_nocicepti1.22238552
58MP0009046_muscle_twitch1.21296268
59MP0005386_behavior/neurological_phenoty1.20106928
60MP0004924_abnormal_behavior1.20106928
61MP0002733_abnormal_thermal_nociception1.19872524
62MP0003635_abnormal_synaptic_transmissio1.15767507
63MP0005075_abnormal_melanosome_morpholog1.14730136
64MP0003806_abnormal_nucleotide_metabolis1.13143933
65MP0001293_anophthalmia1.11453000
66MP0005551_abnormal_eye_electrophysiolog1.10431611
67MP0008877_abnormal_DNA_methylation1.10150282
68MP0002102_abnormal_ear_morphology1.09974178
69MP0002095_abnormal_skin_pigmentation1.09546103
70MP0002876_abnormal_thyroid_physiology1.09265248
71MP0005171_absent_coat_pigmentation1.08387017
72MP0003186_abnormal_redox_activity1.08180841
73MP0002735_abnormal_chemical_nociception1.08088643
74MP0000026_abnormal_inner_ear1.07335564
75MP0005646_abnormal_pituitary_gland1.06974445
76MP0005636_abnormal_mineral_homeostasis1.06842493
77MP0005499_abnormal_olfactory_system1.05667353
78MP0005394_taste/olfaction_phenotype1.05667353
79MP0004085_abnormal_heartbeat1.05523958
80MP0003878_abnormal_ear_physiology1.05327907
81MP0005377_hearing/vestibular/ear_phenot1.05327907
82MP0002160_abnormal_reproductive_system1.04275646
83MP0004270_analgesia1.03797670
84MP0004133_heterotaxia1.03409593
85MP0005389_reproductive_system_phenotype1.02594657
86MP0001501_abnormal_sleep_pattern1.01580218
87MP0000462_abnormal_digestive_system1.01493589
88MP0002210_abnormal_sex_determination1.00652148
89MP0001986_abnormal_taste_sensitivity1.00216002
90MP0000778_abnormal_nervous_system0.99995031
91MP0002972_abnormal_cardiac_muscle0.98974429
92MP0000372_irregular_coat_pigmentation0.98662348
93MP0002332_abnormal_exercise_endurance0.98615429
94MP0001919_abnormal_reproductive_system0.98609147
95MP0010094_abnormal_chromosome_stability0.98357935
96MP0004381_abnormal_hair_follicle0.98279083
97MP0006292_abnormal_olfactory_placode0.97759753
98MP0000230_abnormal_systemic_arterial0.97244008
99MP0002277_abnormal_respiratory_mucosa0.96626259
100MP0003938_abnormal_ear_development0.95888250
101MP0004084_abnormal_cardiac_muscle0.94595108
102MP0001963_abnormal_hearing_physiology0.94365043
103MP0010386_abnormal_urinary_bladder0.94163543
104MP0005332_abnormal_amino_acid0.94155709
105MP0003718_maternal_effect0.92912974
106MP0005535_abnormal_body_temperature0.92491636
107MP0005620_abnormal_muscle_contractility0.92472548
108MP0002751_abnormal_autonomic_nervous0.92047247
109MP0004019_abnormal_vitamin_homeostasis0.91710172
110MP0005451_abnormal_body_composition0.91098107
111MP0004885_abnormal_endolymph0.90482270
112MP0002229_neurodegeneration0.90390543
113MP0002557_abnormal_social/conspecific_i0.88960797
114MP0002063_abnormal_learning/memory/cond0.88640972
115MP0001664_abnormal_digestion0.88317616
116MP0002106_abnormal_muscle_physiology0.87810693
117MP0003315_abnormal_perineum_morphology0.87706674
118MP0008875_abnormal_xenobiotic_pharmacok0.87403258
119MP0005410_abnormal_fertilization0.86362278
120MP0002752_abnormal_somatic_nervous0.85354904
121MP0005174_abnormal_tail_pigmentation0.84632957
122MP0005084_abnormal_gallbladder_morpholo0.84273712
123MP0002066_abnormal_motor_capabilities/c0.84027169
124MP0003123_paternal_imprinting0.83523814
125MP0004484_altered_response_of0.83172974
126MP0001324_abnormal_eye_pigmentation0.81000156
127MP0003283_abnormal_digestive_organ0.80607793
128MP0002938_white_spotting0.80302474
129MP0005253_abnormal_eye_physiology0.80015178
130MP0005195_abnormal_posterior_eye0.79875212
131MP0000750_abnormal_muscle_regeneration0.79324021
132MP0003634_abnormal_glial_cell0.78859197
133MP0003950_abnormal_plasma_membrane0.78802872
134MP0008872_abnormal_physiological_respon0.78461945
135MP0001346_abnormal_lacrimal_gland0.78333204
136MP0000653_abnormal_sex_gland0.78118700
137MP0001929_abnormal_gametogenesis0.78000371
138MP0002234_abnormal_pharynx_morphology0.77034015
139MP0003121_genomic_imprinting0.76883562
140MP0002295_abnormal_pulmonary_circulatio0.76690856
141MP0002090_abnormal_vision0.76534437
142MP0001145_abnormal_male_reproductive0.76330127
143MP0000566_synostosis0.74343525
144MP0003077_abnormal_cell_cycle0.73285863
145MP0000049_abnormal_middle_ear0.72030514
146MP0003787_abnormal_imprinting0.71981131
147MP0009697_abnormal_copulation0.70120815

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.59682355
2Abnormal mitochondria in muscle tissue (HP:0008316)6.83765976
3* Mitochondrial inheritance (HP:0001427)6.55887984
4Acute encephalopathy (HP:0006846)6.38921693
5Progressive macrocephaly (HP:0004481)6.33513237
6Increased hepatocellular lipid droplets (HP:0006565)5.57072200
7* Increased CSF lactate (HP:0002490)5.37325829
8Lipid accumulation in hepatocytes (HP:0006561)5.09997449
9* Hepatocellular necrosis (HP:0001404)5.07183154
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.97588550
11Renal Fanconi syndrome (HP:0001994)4.94185576
12Cerebral edema (HP:0002181)4.65181384
13* Hepatic necrosis (HP:0002605)4.61178488
14Increased intramyocellular lipid droplets (HP:0012240)4.56621277
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.39610953
16Optic disc pallor (HP:0000543)4.11465343
17Increased muscle lipid content (HP:0009058)4.09630111
18Decreased activity of mitochondrial respiratory chain (HP:0008972)4.08509579
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.08509579
20Exercise intolerance (HP:0003546)4.06880357
21* Respiratory failure (HP:0002878)3.85895364
22Leukodystrophy (HP:0002415)3.81779011
23* Lactic acidosis (HP:0003128)3.72458076
243-Methylglutaconic aciduria (HP:0003535)3.67203899
25Exertional dyspnea (HP:0002875)3.60331780
26Abnormality of cells of the erythroid lineage (HP:0012130)3.45262352
27Abnormality of glycolysis (HP:0004366)3.36453467
28Increased serum pyruvate (HP:0003542)3.36453467
29Abnormality of renal resorption (HP:0011038)3.22889400
30Neuroendocrine neoplasm (HP:0100634)3.21471403
31* Increased serum lactate (HP:0002151)3.14068940
32Pheochromocytoma (HP:0002666)3.07847463
33Respiratory difficulties (HP:0002880)2.98065653
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.94991316
35Abnormal number of erythroid precursors (HP:0012131)2.89223561
36Hyperphosphaturia (HP:0003109)2.77365489
37Parakeratosis (HP:0001036)2.75110190
38Congenital, generalized hypertrichosis (HP:0004540)2.73366306
39X-linked dominant inheritance (HP:0001423)2.72700023
40Abnormality of urine glucose concentration (HP:0011016)2.71916815
41Glycosuria (HP:0003076)2.71916815
42Macrocytic anemia (HP:0001972)2.71876399
43Abnormality of midbrain morphology (HP:0002418)2.68158395
44Molar tooth sign on MRI (HP:0002419)2.68158395
45Pancreatic fibrosis (HP:0100732)2.67951574
46Pancreatic cysts (HP:0001737)2.66297528
47Type I transferrin isoform profile (HP:0003642)2.61552478
48Muscle hypertrophy of the lower extremities (HP:0008968)2.53537893
49Generalized aminoaciduria (HP:0002909)2.50357500
50Lethargy (HP:0001254)2.46923875
51True hermaphroditism (HP:0010459)2.43625128
52Aplastic anemia (HP:0001915)2.40545484
53Abnormal urine phosphate concentration (HP:0012599)2.35855375
54Abnormal pupillary function (HP:0007686)2.27758988
55Cerebral hemorrhage (HP:0001342)2.22109898
56Calf muscle hypertrophy (HP:0008981)2.21949181
57Reticulocytopenia (HP:0001896)2.17727613
58Sudden death (HP:0001699)2.17689664
59Hyperglycinemia (HP:0002154)2.15000419
60Nephronophthisis (HP:0000090)2.14449655
61Hypothermia (HP:0002045)2.14064823
62Sensory axonal neuropathy (HP:0003390)2.12705550
63Congenital ichthyosiform erythroderma (HP:0007431)2.08494891
64Limb dystonia (HP:0002451)2.08460511
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07351775
66Sclerocornea (HP:0000647)2.07209044
67Methylmalonic aciduria (HP:0012120)2.05442555
68Abnormal protein glycosylation (HP:0012346)2.05151529
69Abnormal glycosylation (HP:0012345)2.05151529
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05151529
71Abnormal protein N-linked glycosylation (HP:0012347)2.05151529
72* CNS demyelination (HP:0007305)2.01680920
73Pallor (HP:0000980)2.01256510
74Dicarboxylic aciduria (HP:0003215)1.99167131
75Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99167131
76Colon cancer (HP:0003003)1.98879644
77Renal tubular dysfunction (HP:0000124)1.96814008
78* Emotional lability (HP:0000712)1.95972914
79Oral leukoplakia (HP:0002745)1.94658681
80Progressive external ophthalmoplegia (HP:0000590)1.91551282
81Vomiting (HP:0002013)1.89203478
82Absent thumb (HP:0009777)1.88232472
83Abnormal ciliary motility (HP:0012262)1.87231025
84Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87170207
85Methylmalonic acidemia (HP:0002912)1.85698651
86Myokymia (HP:0002411)1.81421139
87Pancytopenia (HP:0001876)1.81220655
88Amniotic constriction ring (HP:0009775)1.79753900
89Abnormality of placental membranes (HP:0011409)1.79753900
90Abnormality of the labia minora (HP:0012880)1.78445211
91Abnormal respiratory motile cilium morphology (HP:0005938)1.76594593
92Abnormal respiratory epithelium morphology (HP:0012253)1.76594593
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76073483
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.76073483
95Rimmed vacuoles (HP:0003805)1.74230974
96Abnormality of the anterior horn cell (HP:0006802)1.73596662
97Degeneration of anterior horn cells (HP:0002398)1.73596662
98Palpitations (HP:0001962)1.73552569
99Abnormal hemoglobin (HP:0011902)1.71849359
100Septo-optic dysplasia (HP:0100842)1.70567316
101Reduced antithrombin III activity (HP:0001976)1.70248312
102Congenital primary aphakia (HP:0007707)1.68209143
103Blindness (HP:0000618)1.67813935
104Gait imbalance (HP:0002141)1.64616406
105Male pseudohermaphroditism (HP:0000037)1.63343790
106Rib fusion (HP:0000902)1.63330333
107Hyperalaninemia (HP:0003348)1.62932715
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62932715
109Abnormality of alanine metabolism (HP:0010916)1.62932715
110Retinal dysplasia (HP:0007973)1.62721346
111Abnormality of serum amino acid levels (HP:0003112)1.62637877
112Anencephaly (HP:0002323)1.61927521
113Nausea (HP:0002018)1.61448428
114Aplasia/hypoplasia of the uterus (HP:0008684)1.61288149
115Prolonged QT interval (HP:0001657)1.60788091
116Nephrogenic diabetes insipidus (HP:0009806)1.60616106
117Rhinitis (HP:0012384)1.58584483
118Hypoplastic left heart (HP:0004383)1.58271053
119Abnormality of the renal medulla (HP:0100957)1.57382154
120Hyperventilation (HP:0002883)1.57212141
121Concave nail (HP:0001598)1.54715103
122Congenital stationary night blindness (HP:0007642)1.53620816
123Cleft eyelid (HP:0000625)1.53511863
124Muscle stiffness (HP:0003552)1.52270864
125Abnormality of the calf musculature (HP:0001430)1.51763110
126Abnormality of aromatic amino acid family metabolism (HP:0004338)1.50953326
127Medial flaring of the eyebrow (HP:0010747)1.50047304
128Myotonia (HP:0002486)1.48930046
129Microvesicular hepatic steatosis (HP:0001414)1.48216631
130Abnormal respiratory motile cilium physiology (HP:0012261)1.47441290
131Neurofibrillary tangles (HP:0002185)1.47218863
132Exercise-induced myalgia (HP:0003738)1.45604893
133Absent/shortened dynein arms (HP:0200106)1.45573123
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.45573123
135Focal motor seizures (HP:0011153)1.45517610
136Ventricular tachycardia (HP:0004756)1.45149540
137Abnormality of secondary sexual hair (HP:0009888)1.42480255
138Abnormality of the axillary hair (HP:0100134)1.42480255
139Hypomagnesemia (HP:0002917)1.40858521
140Abnormality of magnesium homeostasis (HP:0004921)1.40658674
141Muscle fiber splitting (HP:0003555)1.40195475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.24620021
2NME23.57924817
3STK393.43614212
4NME13.02433036
5MAP3K122.85633003
6TLK12.85410467
7ZAK2.80574958
8PBK2.59211661
9PNCK2.58952770
10STK162.57429164
11CASK2.53734475
12WNK42.45455883
13MYLK2.31610645
14OXSR12.16771791
15MUSK2.04423972
16ARAF1.96251046
17TNIK1.91472274
18NUAK11.88537052
19BMPR1B1.85211973
20LIMK11.80472838
21GRK71.80242297
22CDC71.78484017
23CDK191.77270999
24OBSCN1.73580989
25MST41.63666828
26NEK11.62424539
27TAOK31.54282370
28PINK11.51357672
29BCKDK1.48518810
30TAF11.37393931
31EPHB21.35556394
32MAPKAPK51.34696862
33WNK11.33025576
34CAMK2D1.30188307
35GRK51.30075928
36PKN11.30059221
37BCR1.28609091
38MAP4K21.28089499
39BRAF1.27756566
40MAP3K111.25080043
41UHMK11.20501127
42IRAK21.20094354
43VRK11.17961655
44FRK1.16256685
45CAMK2B1.16137785
46ADRBK21.15657926
47PHKG21.15467692
48PHKG11.15467692
49ABL21.15140317
50PDK21.15043393
51PLK31.14005653
52MAP2K71.06419416
53ADRBK11.06214920
54MAPK151.03018201
55DYRK20.99134888
56PLK40.98577508
57CAMK2A0.96851300
58CAMK2G0.96693520
59MAP2K20.96011286
60TESK10.95899303
61EIF2AK30.94078609
62DAPK30.93581375
63FGR0.92691767
64SRPK10.89380561
65PIK3CA0.88518680
66BUB10.88417137
67PLK10.88132368
68ROCK20.87410342
69AURKB0.86419865
70CCNB10.84382002
71PASK0.82209136
72ILK0.80510335
73IRAK30.79533376
74CSNK1G30.78952721
75MST1R0.76519314
76TESK20.74220194
77BRSK20.73171206
78PIM20.72872029
79BMPR20.71725129
80PIK3CG0.71443433
81DYRK30.70450040
82BRSK10.67063357
83TRIM280.67041086
84TTK0.64186047
85STK40.63813271
86MAPK130.63494790
87CHEK20.62284453
88MARK10.62134884
89EIF2AK10.61989931
90LRRK20.61917079
91PRKACA0.61812699
92RIPK40.60290446
93PRKCE0.59275506
94TXK0.59262511
95INSRR0.58059601
96IRAK10.57534748
97CDK80.55456451
98PRKCI0.54507929
99DAPK10.53144007
100PTK2B0.52114467
101ACVR1B0.51683832
102ATR0.51304057
103MAP3K40.50016064
104IRAK40.49687518
105RPS6KA50.49200595
106IKBKB0.47799466
107AURKA0.47698550
108WNK30.47456605
109KDR0.47094154
110MAP2K40.46890950
111CSNK1G10.45733250
112PRKCQ0.45331759
113EPHA40.45017330
114PAK30.43250639
115LMTK20.41568607
116CSNK1A1L0.41102380
117CDK140.40044257
118CSNK2A10.39404758
119MOS0.38879257
120CSNK1A10.38758836
121CSNK2A20.37095216
122CAMK10.37043974
123PRKCG0.34476787
124CDK11A0.34014068
125PLK20.33375770
126NEK20.32263667
127WEE10.31113952
128CSNK1G20.30228480
129PRKG10.29995880
130CDK150.29515089
131TGFBR10.29387441
132GRK10.29314128
133MINK10.29274671
134NTRK10.29133125
135PAK10.28865406
136MAPK40.28697842
137GRK60.28399428
138ROCK10.28019994
139PRKCA0.27462282

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.82337388
2Parkinsons disease_Homo sapiens_hsa050125.76990684
3Alzheimers disease_Homo sapiens_hsa050104.45057965
4Ribosome_Homo sapiens_hsa030104.18003159
5Huntingtons disease_Homo sapiens_hsa050163.98087010
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.81466159
7Cardiac muscle contraction_Homo sapiens_hsa042603.21638879
8Protein export_Homo sapiens_hsa030602.91726055
9Proteasome_Homo sapiens_hsa030502.52531992
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33592567
11Fatty acid elongation_Homo sapiens_hsa000622.25015727
12Sulfur metabolism_Homo sapiens_hsa009202.10693844
13Mismatch repair_Homo sapiens_hsa034301.99700063
14DNA replication_Homo sapiens_hsa030301.81557689
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71810838
16RNA polymerase_Homo sapiens_hsa030201.57642582
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57346356
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47720376
19Collecting duct acid secretion_Homo sapiens_hsa049661.46803469
20Nucleotide excision repair_Homo sapiens_hsa034201.39420437
21Sulfur relay system_Homo sapiens_hsa041221.37296908
22Propanoate metabolism_Homo sapiens_hsa006401.36151249
23Fanconi anemia pathway_Homo sapiens_hsa034601.25359790
24Base excision repair_Homo sapiens_hsa034101.25118167
25Butanoate metabolism_Homo sapiens_hsa006501.24042370
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19763013
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11262397
28RNA degradation_Homo sapiens_hsa030181.10042241
29Vibrio cholerae infection_Homo sapiens_hsa051101.09875180
30Pyruvate metabolism_Homo sapiens_hsa006201.08530408
31One carbon pool by folate_Homo sapiens_hsa006701.07630041
32Steroid biosynthesis_Homo sapiens_hsa001000.92944448
33* Metabolic pathways_Homo sapiens_hsa011000.91441736
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90191137
35Tyrosine metabolism_Homo sapiens_hsa003500.86650839
36Linoleic acid metabolism_Homo sapiens_hsa005910.85056709
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84459820
38Arachidonic acid metabolism_Homo sapiens_hsa005900.83589250
39Ether lipid metabolism_Homo sapiens_hsa005650.83318623
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82149322
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76784730
42Histidine metabolism_Homo sapiens_hsa003400.75836888
43Glutathione metabolism_Homo sapiens_hsa004800.75575153
44RNA transport_Homo sapiens_hsa030130.71784680
45Pyrimidine metabolism_Homo sapiens_hsa002400.71588327
46Arginine and proline metabolism_Homo sapiens_hsa003300.71576024
47Folate biosynthesis_Homo sapiens_hsa007900.70942488
48Phenylalanine metabolism_Homo sapiens_hsa003600.70600581
49Peroxisome_Homo sapiens_hsa041460.70032449
50Nicotine addiction_Homo sapiens_hsa050330.68899391
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.66490477
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65439289
53Serotonergic synapse_Homo sapiens_hsa047260.64728781
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64650235
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63542895
56Rheumatoid arthritis_Homo sapiens_hsa053230.63209217
57Phototransduction_Homo sapiens_hsa047440.62269157
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62116368
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61694265
60Carbon metabolism_Homo sapiens_hsa012000.54619280
61Chemical carcinogenesis_Homo sapiens_hsa052040.53666373
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53606467
63Nitrogen metabolism_Homo sapiens_hsa009100.53533675
64Fatty acid degradation_Homo sapiens_hsa000710.50750426
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49712333
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49021609
67beta-Alanine metabolism_Homo sapiens_hsa004100.48941106
68Non-homologous end-joining_Homo sapiens_hsa034500.47995581
69Fatty acid metabolism_Homo sapiens_hsa012120.47873222
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46873945
71Taste transduction_Homo sapiens_hsa047420.46408977
72GABAergic synapse_Homo sapiens_hsa047270.45808408
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45615295
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.44845888
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44276940
76Regulation of autophagy_Homo sapiens_hsa041400.44077339
77Purine metabolism_Homo sapiens_hsa002300.41352323
78Selenocompound metabolism_Homo sapiens_hsa004500.41168688
79Vitamin digestion and absorption_Homo sapiens_hsa049770.41056263
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41008859
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.40837415
82Mineral absorption_Homo sapiens_hsa049780.39328022
83Caffeine metabolism_Homo sapiens_hsa002320.39055869
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.37453452
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37179293
86Sphingolipid metabolism_Homo sapiens_hsa006000.36841867
87Graft-versus-host disease_Homo sapiens_hsa053320.34239436
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32937698
89Synaptic vesicle cycle_Homo sapiens_hsa047210.32487641
90Homologous recombination_Homo sapiens_hsa034400.31052870
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28908032
92Phagosome_Homo sapiens_hsa041450.28595904
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27491341
94Retinol metabolism_Homo sapiens_hsa008300.27478334
95Morphine addiction_Homo sapiens_hsa050320.26600101
96Autoimmune thyroid disease_Homo sapiens_hsa053200.26277010
97Type I diabetes mellitus_Homo sapiens_hsa049400.26238510
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.25649375
99Fat digestion and absorption_Homo sapiens_hsa049750.25557342
100N-Glycan biosynthesis_Homo sapiens_hsa005100.25365190
101Tryptophan metabolism_Homo sapiens_hsa003800.24335488
102Biosynthesis of amino acids_Homo sapiens_hsa012300.24280167
103Primary immunodeficiency_Homo sapiens_hsa053400.23124887
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21181603
105Asthma_Homo sapiens_hsa053100.21019483
106Dilated cardiomyopathy_Homo sapiens_hsa054140.20684313
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19872129
108Spliceosome_Homo sapiens_hsa030400.19822253
109Glutamatergic synapse_Homo sapiens_hsa047240.19750974
110Calcium signaling pathway_Homo sapiens_hsa040200.19282294
111Long-term depression_Homo sapiens_hsa047300.18880709
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18265468
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17324900
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17208179
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16201792
116Cocaine addiction_Homo sapiens_hsa050300.16091444
117Basal transcription factors_Homo sapiens_hsa030220.16022360
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.15100192
119Pancreatic secretion_Homo sapiens_hsa049720.14173746
120Renin secretion_Homo sapiens_hsa049240.12949758
121Alcoholism_Homo sapiens_hsa050340.12613015
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.12194460
123Allograft rejection_Homo sapiens_hsa053300.12055071
124Salivary secretion_Homo sapiens_hsa049700.11536140
125Dopaminergic synapse_Homo sapiens_hsa047280.11445352
126Systemic lupus erythematosus_Homo sapiens_hsa053220.10952284
127Circadian entrainment_Homo sapiens_hsa047130.10365292
128Amphetamine addiction_Homo sapiens_hsa050310.09515762
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09216115

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