NDUFA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.26523283
2* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.74259029
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.60815282
4ATP synthesis coupled proton transport (GO:0015986)8.60815282
5* respiratory electron transport chain (GO:0022904)7.96982439
6* electron transport chain (GO:0022900)7.75971290
7central nervous system myelination (GO:0022010)6.12317477
8axon ensheathment in central nervous system (GO:0032291)6.12317477
9maturation of 5.8S rRNA (GO:0000460)5.94201512
10chaperone-mediated protein transport (GO:0072321)5.15298036
11protein complex biogenesis (GO:0070271)4.92095556
12protein-cofactor linkage (GO:0018065)4.80941960
13protein neddylation (GO:0045116)4.79541287
14hydrogen ion transmembrane transport (GO:1902600)4.78267401
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.71682995
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.71682995
17NADH dehydrogenase complex assembly (GO:0010257)4.71682995
18fatty acid elongation (GO:0030497)4.66977354
19ATP biosynthetic process (GO:0006754)4.62313796
20DNA deamination (GO:0045006)4.60114769
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.45317227
22termination of RNA polymerase III transcription (GO:0006386)4.41748255
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.41748255
24purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.40434634
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.35962129
26mitochondrial respiratory chain complex assembly (GO:0033108)4.35124573
27purine nucleoside triphosphate biosynthetic process (GO:0009145)4.30866219
28inner mitochondrial membrane organization (GO:0007007)4.29967372
29proton transport (GO:0015992)4.26881110
30nucleotide transmembrane transport (GO:1901679)4.24809731
31protein complex disassembly (GO:0043241)4.18076055
32hydrogen transport (GO:0006818)4.17936093
33protein import into peroxisome matrix (GO:0016558)4.15744079
34maturation of SSU-rRNA (GO:0030490)4.14977623
35ribosomal small subunit biogenesis (GO:0042274)4.12015630
36translational initiation (GO:0006413)4.08051120
37viral transcription (GO:0019083)3.97213463
38negative regulation of protein oligomerization (GO:0032460)3.96673712
39platelet dense granule organization (GO:0060155)3.94475962
40macromolecular complex disassembly (GO:0032984)3.94028423
41spliceosomal snRNP assembly (GO:0000387)3.82889750
42ribonucleoside triphosphate biosynthetic process (GO:0009201)3.77868390
43translational termination (GO:0006415)3.74925914
44sequestering of actin monomers (GO:0042989)3.69253209
45long-chain fatty acid biosynthetic process (GO:0042759)3.65479619
46GTP biosynthetic process (GO:0006183)3.63857568
47cotranslational protein targeting to membrane (GO:0006613)3.61831976
48substantia nigra development (GO:0021762)3.58075616
49protein targeting to ER (GO:0045047)3.53690903
50intracellular protein transmembrane transport (GO:0065002)3.47381391
51SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47325050
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45087215
53establishment of protein localization to endoplasmic reticulum (GO:0072599)3.42540968
54oxidative phosphorylation (GO:0006119)3.41176769
55protein localization to endoplasmic reticulum (GO:0070972)3.39635500
56behavioral response to nicotine (GO:0035095)3.36749176
57cellular component biogenesis (GO:0044085)3.36085972
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35797513
59myelination (GO:0042552)3.35066974
60axon ensheathment (GO:0008366)3.34196029
61ensheathment of neurons (GO:0007272)3.34196029
62negative regulation of telomere maintenance (GO:0032205)3.32235521
63regulation of mitochondrial translation (GO:0070129)3.32060659
64nuclear-transcribed mRNA catabolic process (GO:0000956)3.27748156
65respiratory chain complex IV assembly (GO:0008535)3.26641074
66creatine metabolic process (GO:0006600)3.22853887
67protein targeting to mitochondrion (GO:0006626)3.22388072
68negative regulation of protein localization to cell surface (GO:2000009)3.19396817
69aerobic respiration (GO:0009060)3.18566296
70protein transmembrane transport (GO:0071806)3.18457065
71positive regulation of action potential (GO:0045760)3.18083970
72cellular response to epinephrine stimulus (GO:0071872)3.17529910
73mitochondrial transport (GO:0006839)3.13272200
74cytochrome complex assembly (GO:0017004)3.11507327
75nucleoside triphosphate biosynthetic process (GO:0009142)3.09673264
76mRNA catabolic process (GO:0006402)3.07880552
77establishment of protein localization to mitochondrion (GO:0072655)3.06047159
78RNA capping (GO:0036260)3.05745883
797-methylguanosine RNA capping (GO:0009452)3.05745883
80ribosomal small subunit assembly (GO:0000028)3.00900763
81GPI anchor biosynthetic process (GO:0006506)3.00462498
82cellular protein complex disassembly (GO:0043624)2.98703376
83rRNA modification (GO:0000154)2.98641091
84water-soluble vitamin biosynthetic process (GO:0042364)2.98482197
85pseudouridine synthesis (GO:0001522)2.96981877
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96800441
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96800441
88response to epinephrine (GO:0071871)2.96215980
89viral life cycle (GO:0019058)2.94775320
90ribonucleoprotein complex biogenesis (GO:0022613)2.94584504
91purine nucleoside monophosphate biosynthetic process (GO:0009127)2.92632491
92purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.92632491
93translational elongation (GO:0006414)2.88232944
94quinone biosynthetic process (GO:1901663)2.87002149
95ubiquinone biosynthetic process (GO:0006744)2.87002149
96protein localization to mitochondrion (GO:0070585)2.85367620
97presynaptic membrane assembly (GO:0097105)2.83546056
98proteasome assembly (GO:0043248)2.81912079
99RNA catabolic process (GO:0006401)2.81571405
100UTP biosynthetic process (GO:0006228)2.78299620
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76918252
102presynaptic membrane organization (GO:0097090)2.74675103
103rRNA metabolic process (GO:0016072)2.74156993
104regulation of cell communication by electrical coupling (GO:0010649)2.72267567
105energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.70978332
106ATP hydrolysis coupled proton transport (GO:0015991)2.70978332
107rRNA processing (GO:0006364)2.70155228
108mitochondrion morphogenesis (GO:0070584)2.69707040
109short-term memory (GO:0007614)2.67880234
110protein targeting (GO:0006605)2.67666578
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67245973
112protein targeting to peroxisome (GO:0006625)2.67022478
113establishment of protein localization to peroxisome (GO:0072663)2.67022478
114protein localization to peroxisome (GO:0072662)2.67022478
115GPI anchor metabolic process (GO:0006505)2.66990806
116ubiquinone metabolic process (GO:0006743)2.65172508
117spliceosomal complex assembly (GO:0000245)2.64157636
118mannosylation (GO:0097502)2.64027891
119response to redox state (GO:0051775)2.63557236
120* generation of precursor metabolites and energy (GO:0006091)2.63505992
121regulation of relaxation of muscle (GO:1901077)2.63483222
122amyloid precursor protein metabolic process (GO:0042982)2.61449359
123regulation of dopamine metabolic process (GO:0042053)2.60208360
124regulation of catecholamine metabolic process (GO:0042069)2.60208360
125ribosomal large subunit biogenesis (GO:0042273)2.59319202
126translation (GO:0006412)2.59039362
127deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57376658
128negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.53952901
129intracellular protein transmembrane import (GO:0044743)2.53732424
130regulation of protein homooligomerization (GO:0032462)2.53571158
131positive regulation of prostaglandin secretion (GO:0032308)2.53229822
132cholesterol biosynthetic process (GO:0006695)2.51949457
133nucleoside diphosphate phosphorylation (GO:0006165)2.51191674
134neuron cell-cell adhesion (GO:0007158)2.50895471
135base-excision repair, AP site formation (GO:0006285)2.49721762
136UTP metabolic process (GO:0046051)2.49122227
137establishment of protein localization to membrane (GO:0090150)2.48461531
138aldehyde catabolic process (GO:0046185)2.48280708
139regulation of actin filament-based movement (GO:1903115)2.47614114
140oligodendrocyte differentiation (GO:0048709)2.45187546
141neural nucleus development (GO:0048857)2.44265949
142sarcomere organization (GO:0045214)2.42892965
143protein targeting to membrane (GO:0006612)2.39841458
144neurotransmitter catabolic process (GO:0042135)2.37063867
145dopamine transport (GO:0015872)2.36802763
146CTP metabolic process (GO:0046036)2.34979747
147CTP biosynthetic process (GO:0006241)2.34979747
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.34909473
149adhesion of symbiont to host cell (GO:0044650)2.33607825
150virion attachment to host cell (GO:0019062)2.33607825
151positive regulation of cellular amine metabolic process (GO:0033240)2.33385555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.54974376
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92504800
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.46731411
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19411164
5EZH2_22144423_ChIP-Seq_EOC_Human3.17815239
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03456040
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92199440
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70866395
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.55010617
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.38376717
11TAF15_26573619_Chip-Seq_HEK293_Human2.36170937
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33718791
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31933672
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.20996640
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.17645612
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11721939
17VDR_23849224_ChIP-Seq_CD4+_Human2.10881892
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08539661
19ZNF274_21170338_ChIP-Seq_K562_Hela2.05119923
20GBX2_23144817_ChIP-Seq_PC3_Human2.02582492
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97876913
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94810492
23* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.91467102
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89871271
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88523035
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.88498251
27VDR_22108803_ChIP-Seq_LS180_Human1.87312870
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86618803
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85649128
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85052135
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84074574
32FOXP3_21729870_ChIP-Seq_TREG_Human1.83749861
33ELK1_19687146_ChIP-ChIP_HELA_Human1.83307739
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.82137833
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81878403
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80169573
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76610097
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75669763
39* ETS1_20019798_ChIP-Seq_JURKAT_Human1.72579674
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.61757483
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59341992
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.57784053
43TTF2_22483619_ChIP-Seq_HELA_Human1.57194953
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56506619
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.54905445
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53704396
47ER_23166858_ChIP-Seq_MCF-7_Human1.51318100
48XRN2_22483619_ChIP-Seq_HELA_Human1.50713582
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47066510
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46827970
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46080771
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46062183
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45683416
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42921926
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40166015
56* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37673466
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.37401178
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37268662
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35739349
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34853057
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34467072
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33788518
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33788518
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32049010
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30918030
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25531839
67* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25113327
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23767327
69* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23227493
70TP53_22573176_ChIP-Seq_HFKS_Human1.23060109
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23004468
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20700609
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20468393
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20214957
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18368156
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.18307923
77TAF2_19829295_ChIP-Seq_ESCs_Human1.17959323
78GABP_19822575_ChIP-Seq_HepG2_Human1.17709778
79IRF1_19129219_ChIP-ChIP_H3396_Human1.16252645
80EWS_26573619_Chip-Seq_HEK293_Human1.16073021
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.15598371
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15317055
83STAT1_20625510_ChIP-Seq_HELA_Human1.14526080
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13991665
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.13991665
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13115486
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12786842
88IGF1R_20145208_ChIP-Seq_DFB_Human1.12385197
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.11615628
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11196080
91ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11171321
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11151486
93* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.10550744
94AR_20517297_ChIP-Seq_VCAP_Human1.10464079
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08054581
96* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07826969
97* YY1_21170310_ChIP-Seq_MESCs_Mouse1.06971329
98HTT_18923047_ChIP-ChIP_STHdh_Human1.05306085
99MYC_19829295_ChIP-Seq_ESCs_Human1.04769810
100NANOG_20526341_ChIP-Seq_ESCs_Human1.04575183
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.03552472
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02952084
103FUS_26573619_Chip-Seq_HEK293_Human1.02840327
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02830655
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01576529
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01385498
107TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01187041
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01152113
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.00432660
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00081347
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99960157
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98136621
113YY1_22570637_ChIP-Seq_MALME-3M_Human0.97773373
114ERA_21632823_ChIP-Seq_H3396_Human0.97414260
115P300_19829295_ChIP-Seq_ESCs_Human0.95395632
116TAL1_26923725_Chip-Seq_HPCs_Mouse0.93165551
117P53_21459846_ChIP-Seq_SAOS-2_Human0.92794585
118NCOR_22424771_ChIP-Seq_293T_Human0.91018638
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91006956
120* CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90971142
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88554532
122* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88554311
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87520351
124REST_21632747_ChIP-Seq_MESCs_Mouse0.87283068
125HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86811769
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85656598
127SOX2_19829295_ChIP-Seq_ESCs_Human0.85506724
128NANOG_19829295_ChIP-Seq_ESCs_Human0.85506724
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84454946
130ERG_20517297_ChIP-Seq_VCAP_Human0.84451110
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84119517
132DCP1A_22483619_ChIP-Seq_HELA_Human0.83889432
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.83516455
134SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81865802
135E2F1_20622854_ChIP-Seq_HELA_Human0.81803556
136* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81396623
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80623112
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.80607813
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.79117035
140CTCF_20526341_ChIP-Seq_ESCs_Human0.79109378
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79096283
142HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78522805
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.78010324
144CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.77679997
145MYC_18940864_ChIP-ChIP_HL60_Human0.77652449
146* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77566300
147EOMES_21245162_ChIP-Seq_HESCs_Human0.76951384
148PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76445321
149* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76428416
150TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76112138
151RNF2_27304074_Chip-Seq_NSC_Mouse0.75798153
152IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75528370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.33178879
2MP0003880_abnormal_central_pattern4.19300394
3MP0001529_abnormal_vocalization3.70903141
4MP0002837_dystrophic_cardiac_calcinosis3.50047377
5MP0006082_CNS_inflammation3.34687807
6MP0009379_abnormal_foot_pigmentation3.27539070
7MP0003136_yellow_coat_color3.22201858
8MP0006292_abnormal_olfactory_placode2.87269551
9MP0001905_abnormal_dopamine_level2.83970627
10MP0000920_abnormal_myelination2.75760672
11MP0003646_muscle_fatigue2.48166630
12MP0000751_myopathy2.46322166
13MP0006276_abnormal_autonomic_nervous2.36480607
14MP0004142_abnormal_muscle_tone2.35914276
15MP0006036_abnormal_mitochondrial_physio2.16499735
16MP0004381_abnormal_hair_follicle2.13621506
17MP0004215_abnormal_myocardial_fiber2.12128545
18MP0004036_abnormal_muscle_relaxation2.09820589
19MP0000749_muscle_degeneration2.05435010
20MP0001346_abnormal_lacrimal_gland2.00526865
21MP0002132_abnormal_respiratory_system1.97008660
22MP0003137_abnormal_impulse_conducting1.89700370
23MP0001984_abnormal_olfaction1.87216284
24MP0002653_abnormal_ependyma_morphology1.87145436
25MP0002272_abnormal_nervous_system1.85477258
26MP0005409_darkened_coat_color1.77442546
27MP0001873_stomach_inflammation1.77239809
28MP0003950_abnormal_plasma_membrane1.72644610
29MP0004084_abnormal_cardiac_muscle1.71582810
30MP0005330_cardiomyopathy1.68761872
31MP0003011_delayed_dark_adaptation1.68153158
32MP0002064_seizures1.63145765
33MP0005451_abnormal_body_composition1.62249872
34MP0001485_abnormal_pinna_reflex1.60157214
35MP0004742_abnormal_vestibular_system1.59961279
36MP0005171_absent_coat_pigmentation1.59585826
37MP0005671_abnormal_response_to1.57092211
38MP0000631_abnormal_neuroendocrine_gland1.56657890
39MP0009046_muscle_twitch1.56656215
40MP0005084_abnormal_gallbladder_morpholo1.55175879
41MP0002736_abnormal_nociception_after1.52192843
42MP0001486_abnormal_startle_reflex1.50075812
43MP0004043_abnormal_pH_regulation1.48713170
44MP0002938_white_spotting1.46168946
45MP0001440_abnormal_grooming_behavior1.46055378
46MP0009745_abnormal_behavioral_response1.45793435
47MP0003724_increased_susceptibility_to1.43414544
48MP0003690_abnormal_glial_cell1.42420090
49MP0004145_abnormal_muscle_electrophysio1.41635782
50MP0006035_abnormal_mitochondrial_morpho1.40866337
51MP0004885_abnormal_endolymph1.40383916
52MP0001968_abnormal_touch/_nociception1.39406130
53MP0004270_analgesia1.33677792
54MP0002163_abnormal_gland_morphology1.33229648
55MP0008875_abnormal_xenobiotic_pharmacok1.27587886
56MP0002972_abnormal_cardiac_muscle1.27163403
57MP0004133_heterotaxia1.26576949
58MP0005386_behavior/neurological_phenoty1.24264793
59MP0004924_abnormal_behavior1.24264793
60MP0002734_abnormal_mechanical_nocicepti1.21491785
61MP0005646_abnormal_pituitary_gland1.21329454
62MP0002277_abnormal_respiratory_mucosa1.20130956
63MP0002638_abnormal_pupillary_reflex1.17957185
64MP0010030_abnormal_orbit_morphology1.16828233
65MP0005379_endocrine/exocrine_gland_phen1.16817833
66MP0003878_abnormal_ear_physiology1.16437001
67MP0005377_hearing/vestibular/ear_phenot1.16437001
68MP0001919_abnormal_reproductive_system1.15819931
69MP0003718_maternal_effect1.15575927
70MP0008877_abnormal_DNA_methylation1.15551211
71MP0003938_abnormal_ear_development1.14853837
72MP0000747_muscle_weakness1.14035658
73MP0004147_increased_porphyrin_level1.12873216
74MP0002067_abnormal_sensory_capabilities1.12732251
75MP0001727_abnormal_embryo_implantation1.11899557
76MP0004484_altered_response_of1.11006958
77MP0005423_abnormal_somatic_nervous1.11000318
78MP0008995_early_reproductive_senescence1.10522372
79MP0002229_neurodegeneration1.08819987
80MP0005551_abnormal_eye_electrophysiolog1.08687134
81MP0008004_abnormal_stomach_pH1.06826393
82MP0005389_reproductive_system_phenotype1.06618619
83MP0002332_abnormal_exercise_endurance1.06240193
84MP0000372_irregular_coat_pigmentation1.06161786
85MP0001970_abnormal_pain_threshold1.05674974
86MP0002102_abnormal_ear_morphology1.05426957
87MP0005620_abnormal_muscle_contractility1.05116767
88MP0004085_abnormal_heartbeat1.04898674
89MP0003283_abnormal_digestive_organ1.01479224
90MP0001501_abnormal_sleep_pattern0.99229039
91MP0003634_abnormal_glial_cell0.98611203
92MP0002572_abnormal_emotion/affect_behav0.97801854
93MP0003186_abnormal_redox_activity0.96949180
94MP0003329_amyloid_beta_deposits0.96701834
95MP0003786_premature_aging0.95770959
96MP0002106_abnormal_muscle_physiology0.95680499
97MP0006072_abnormal_retinal_apoptosis0.95547576
98MP0005410_abnormal_fertilization0.95142678
99MP0002148_abnormal_hypersensitivity_rea0.94514528
100MP0000566_synostosis0.94001032
101MP0008872_abnormal_physiological_respon0.92241600
102MP0001293_anophthalmia0.91378973
103MP0000778_abnormal_nervous_system0.91238909
104MP0003195_calcinosis0.90482871
105MP0002822_catalepsy0.90411532
106MP0000230_abnormal_systemic_arterial0.89036199
107MP0001664_abnormal_digestion0.88991897
108MP0005645_abnormal_hypothalamus_physiol0.88797607
109MP0002160_abnormal_reproductive_system0.88566498
110MP0003635_abnormal_synaptic_transmissio0.88338213
111MP0002234_abnormal_pharynx_morphology0.87111569
112MP0008789_abnormal_olfactory_epithelium0.87080680
113MP0000049_abnormal_middle_ear0.85285209
114MP0001986_abnormal_taste_sensitivity0.85283355
115MP0002557_abnormal_social/conspecific_i0.85123253
116MP0008775_abnormal_heart_ventricle0.84284674
117MP0000750_abnormal_muscle_regeneration0.84200081
118MP0005369_muscle_phenotype0.83692833
119MP0000762_abnormal_tongue_morphology0.82677828
120MP0000462_abnormal_digestive_system0.82416595
121MP0001963_abnormal_hearing_physiology0.82117485
122MP0008058_abnormal_DNA_repair0.81606380
123MP0003693_abnormal_embryo_hatching0.81342855
124MP0000026_abnormal_inner_ear0.81332055
125MP0010386_abnormal_urinary_bladder0.80820051
126MP0003806_abnormal_nucleotide_metabolis0.80663893
127MP0005385_cardiovascular_system_phenoty0.80455236
128MP0001544_abnormal_cardiovascular_syste0.80455236
129MP0002876_abnormal_thyroid_physiology0.80171903
130MP0003787_abnormal_imprinting0.79760009
131MP0002693_abnormal_pancreas_physiology0.79173370
132MP0004087_abnormal_muscle_fiber0.79147622
133MP0002733_abnormal_thermal_nociception0.78789710
134MP0006138_congestive_heart_failure0.78560552
135MP0002066_abnormal_motor_capabilities/c0.78091597
136MP0001348_abnormal_lacrimal_gland0.76795547
137MP0005195_abnormal_posterior_eye0.76568895
138MP0004019_abnormal_vitamin_homeostasis0.74655418
139MP0005253_abnormal_eye_physiology0.74474048
140MP0009785_altered_susceptibility_to0.73564668
141MP0002752_abnormal_somatic_nervous0.73348992
142MP0001663_abnormal_digestive_system0.72516824
143MP0009333_abnormal_splenocyte_physiolog0.72281412
144MP0001764_abnormal_homeostasis0.72249653
145MP0002138_abnormal_hepatobiliary_system0.71518706
146MP0008569_lethality_at_weaning0.71116245
147MP0001188_hyperpigmentation0.71031254
148MP0002735_abnormal_chemical_nociception0.70556922
149MP0005636_abnormal_mineral_homeostasis0.69669950

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.83824038
2Mitochondrial inheritance (HP:0001427)6.35048177
3Abnormal mitochondria in muscle tissue (HP:0008316)6.20436352
4Hepatocellular necrosis (HP:0001404)5.82492993
5Progressive macrocephaly (HP:0004481)5.77653085
6Acute encephalopathy (HP:0006846)5.74986580
7Increased CSF lactate (HP:0002490)5.33680721
8Hepatic necrosis (HP:0002605)5.21078132
9Increased hepatocellular lipid droplets (HP:0006565)5.15507549
10Renal Fanconi syndrome (HP:0001994)4.76714004
11Lipid accumulation in hepatocytes (HP:0006561)4.69698960
12Increased intramyocellular lipid droplets (HP:0012240)4.33365113
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.29737286
14Cerebral edema (HP:0002181)4.13422611
15Respiratory failure (HP:0002878)3.91834133
16Leukodystrophy (HP:0002415)3.88093027
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.86417891
18Increased muscle lipid content (HP:0009058)3.85885941
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.74282967
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.74282967
213-Methylglutaconic aciduria (HP:0003535)3.72627590
22Optic disc pallor (HP:0000543)3.66224561
23Exercise intolerance (HP:0003546)3.65248518
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.58288826
25Lactic acidosis (HP:0003128)3.55592816
26Increased serum pyruvate (HP:0003542)3.44874331
27Abnormality of glycolysis (HP:0004366)3.44874331
28Exertional dyspnea (HP:0002875)3.35255516
29Increased serum lactate (HP:0002151)3.34806244
30Parakeratosis (HP:0001036)3.17244652
31Muscle hypertrophy of the lower extremities (HP:0008968)3.09821519
32Aplastic anemia (HP:0001915)3.06279863
33Congenital, generalized hypertrichosis (HP:0004540)3.02396345
34Abnormality of renal resorption (HP:0011038)3.01376699
35Sensory axonal neuropathy (HP:0003390)2.91508935
36Pheochromocytoma (HP:0002666)2.86760556
37Brushfield spots (HP:0001088)2.86505647
38Neuroendocrine neoplasm (HP:0100634)2.85822160
39Calf muscle hypertrophy (HP:0008981)2.80545542
40Respiratory difficulties (HP:0002880)2.77517385
41Pancreatic fibrosis (HP:0100732)2.69389898
42Pancreatic cysts (HP:0001737)2.69377049
43Sudden death (HP:0001699)2.62756375
44Oral leukoplakia (HP:0002745)2.60252600
45Molar tooth sign on MRI (HP:0002419)2.56827350
46Abnormality of midbrain morphology (HP:0002418)2.56827350
47True hermaphroditism (HP:0010459)2.52601732
48Abnormality of urine glucose concentration (HP:0011016)2.52182467
49Glycosuria (HP:0003076)2.52182467
50CNS demyelination (HP:0007305)2.50462146
51Congenital ichthyosiform erythroderma (HP:0007431)2.44370142
52Abnormality of cells of the erythroid lineage (HP:0012130)2.41339425
53Hyperphosphaturia (HP:0003109)2.34225291
54Polyphagia (HP:0002591)2.28766262
55Macrocytic anemia (HP:0001972)2.28048495
56Lethargy (HP:0001254)2.25308194
57Abnormal number of erythroid precursors (HP:0012131)2.25167352
58Muscle fiber splitting (HP:0003555)2.25009228
59Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21787668
60Generalized aminoaciduria (HP:0002909)2.21751112
61X-linked dominant inheritance (HP:0001423)2.19425095
62Abnormal pupillary function (HP:0007686)2.18327155
63Congenital stationary night blindness (HP:0007642)2.17907960
64Cerebral hemorrhage (HP:0001342)2.16987988
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.16389526
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16389526
67Methylmalonic acidemia (HP:0002912)2.14777534
68Septo-optic dysplasia (HP:0100842)2.14286372
69Congenital sensorineural hearing impairment (HP:0008527)2.12555310
70Cerebral hypomyelination (HP:0006808)2.12470727
71Asplenia (HP:0001746)2.12298390
72Emotional lability (HP:0000712)2.12231030
73Nephronophthisis (HP:0000090)2.08318578
74Palpitations (HP:0001962)2.07751858
75Aplasia/Hypoplasia of the spleen (HP:0010451)2.06823203
76Prolonged QT interval (HP:0001657)2.06286348
77Abnormal hemoglobin (HP:0011902)2.06178236
78Ventricular fibrillation (HP:0001663)2.05731932
79Pendular nystagmus (HP:0012043)2.04924548
80Exercise-induced myalgia (HP:0003738)2.04148303
81Pancytopenia (HP:0001876)2.01805989
82Abnormal urine phosphate concentration (HP:0012599)2.01111849
83Sclerocornea (HP:0000647)2.01055395
84Neurofibrillary tangles (HP:0002185)1.99836341
85Type II lissencephaly (HP:0007260)1.98729064
86Abnormal drinking behavior (HP:0030082)1.98441248
87Polydipsia (HP:0001959)1.98441248
88Ventricular tachycardia (HP:0004756)1.98432639
89Reticulocytopenia (HP:0001896)1.97225292
90Type I transferrin isoform profile (HP:0003642)1.96370920
91Abnormal respiratory motile cilium physiology (HP:0012261)1.95883338
92Microvesicular hepatic steatosis (HP:0001414)1.92913186
93Abnormality of the calf musculature (HP:0001430)1.92213158
94Medial flaring of the eyebrow (HP:0010747)1.89359751
95Methylmalonic aciduria (HP:0012120)1.88936616
96Renal tubular dysfunction (HP:0000124)1.88045719
97Flat occiput (HP:0005469)1.86514322
98Dicarboxylic aciduria (HP:0003215)1.84703724
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84703724
100Myokymia (HP:0002411)1.81260649
101Conjunctival hamartoma (HP:0100780)1.80373571
102Atrial fibrillation (HP:0005110)1.79901082
103Abnormality of placental membranes (HP:0011409)1.79622731
104Amniotic constriction ring (HP:0009775)1.79622731
105Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77234418
106Supraventricular tachycardia (HP:0004755)1.75537511
107Female pseudohermaphroditism (HP:0010458)1.74553103
108Hypoplasia of the pons (HP:0012110)1.72499733
109Abnormal rod and cone electroretinograms (HP:0008323)1.72184804
110Primary atrial arrhythmia (HP:0001692)1.72093794
111Abnormality of vitamin B metabolism (HP:0004340)1.71651478
112Syncope (HP:0001279)1.71167756
113Absent thumb (HP:0009777)1.70357530
114Homocystinuria (HP:0002156)1.70278715
115Abnormality of homocysteine metabolism (HP:0010919)1.70278715
116Dilated cardiomyopathy (HP:0001644)1.69926713
117Lipoatrophy (HP:0100578)1.69092157
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68702427
119Abnormal respiratory epithelium morphology (HP:0012253)1.68470519
120Abnormal respiratory motile cilium morphology (HP:0005938)1.68470519
121Male pseudohermaphroditism (HP:0000037)1.68354848
122Retinal dysplasia (HP:0007973)1.68035141
123Spastic paraparesis (HP:0002313)1.67665987
124Aplasia/hypoplasia of the uterus (HP:0008684)1.67440986
125Supraventricular arrhythmia (HP:0005115)1.67187948
126Stomatitis (HP:0010280)1.66570681
127Hypothermia (HP:0002045)1.66021280
128Agnosia (HP:0010524)1.65826050
129Hypoplastic left heart (HP:0004383)1.65503693
130Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65464314
131Progressive external ophthalmoplegia (HP:0000590)1.65421903
132Gliosis (HP:0002171)1.65337614
133Concave nail (HP:0001598)1.65316423
134Respiratory distress (HP:0002098)1.64834078
135Colon cancer (HP:0003003)1.64180793
136Abnormal EKG (HP:0003115)1.64039634
137Abnormality of the vitamin B12 metabolism (HP:0004341)1.63723646
138Vomiting (HP:0002013)1.63333900
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.62682817
140Hypomagnesemia (HP:0002917)1.62441815
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.62233090
142Furrowed tongue (HP:0000221)1.60876758
143Abnormal ciliary motility (HP:0012262)1.60241811
144Abnormality of the renal medulla (HP:0100957)1.60195857
145Optic nerve hypoplasia (HP:0000609)1.59878961
146Polyuria (HP:0000103)1.59838043
147Ileus (HP:0002595)1.59348402
148EMG: myopathic abnormalities (HP:0003458)1.58684741
149Pallor (HP:0000980)1.57591286
150Peripheral hypomyelination (HP:0007182)1.57121516
151Muscle stiffness (HP:0003552)1.55447274
152Neoplasm of head and neck (HP:0012288)1.54779192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.81831739
2VRK24.78275838
3PASK4.05538769
4TLK13.45429376
5OXSR13.15146890
6PBK3.06314885
7NME12.70653487
8WNK42.56976216
9STK162.49245570
10CASK2.49152567
11MYLK2.39019676
12CDK192.37283353
13NME22.36986245
14TNIK2.36092917
15ZAK2.32120792
16MST42.15676566
17WNK32.05266935
18GRK71.98173866
19MUSK1.97890358
20MAP3K121.94975747
21BCR1.93949336
22PKN11.89611191
23MAPKAPK51.79670155
24MAP4K21.71555242
25LMTK21.70495036
26NUAK11.69981455
27OBSCN1.67802477
28LIMK11.66377680
29PHKG21.56709146
30PHKG11.56709146
31BCKDK1.51031388
32INSRR1.40504672
33CAMK2D1.37897731
34CDC71.37388371
35IRAK21.35615041
36ARAF1.28616512
37ADRBK21.21305270
38CAMK2B1.18270279
39ITK1.16857148
40TESK21.16617837
41FRK1.15283539
42MAP3K131.13205005
43IRAK11.12647658
44CSNK1G31.12169582
45IRAK31.11538516
46PRPF4B1.11420581
47ROCK21.11181253
48BMPR1B1.09229848
49IRAK41.06694378
50UHMK11.04031592
51TAF11.03823442
52PNCK1.01604442
53CAMKK11.00583118
54CAMK2G0.99726651
55VRK10.96959473
56DAPK30.95105162
57PIK3CA0.94331316
58WNK10.94080913
59IKBKB0.90640598
60CAMK2A0.90290325
61MAP3K40.89053392
62NEK60.88151283
63PINK10.86119114
64DYRK30.85162920
65PRKCG0.84710479
66MAPK150.84706646
67MET0.83888756
68BUB10.81053711
69ABL20.77734381
70CSNK1G10.75702815
71TESK10.73888320
72MAP2K70.69796988
73PRKCE0.69293162
74EPHB10.68281680
75AURKA0.66063924
76MAP2K20.64187289
77FES0.64162463
78PLK40.63554113
79PLK30.63442436
80EPHA40.62992577
81EIF2AK10.62530973
82ADRBK10.62366477
83DYRK20.62185891
84GRK50.62057690
85FGR0.61288369
86MAP3K110.60437426
87TAOK30.60307685
88LRRK20.59238140
89ILK0.58764905
90PRKCQ0.57207998
91BMPR20.57206094
92CSNK2A10.55946613
93CSNK2A20.55877700
94PLK10.55276215
95BRAF0.54167667
96PRKACA0.53510499
97PIK3CG0.53010011
98PAK30.51756728
99RPS6KA50.50957020
100CSNK1A10.50886330
101CSNK1G20.49879638
102CSNK1A1L0.48421781
103CHEK20.47235968
104ROCK10.46901829
105MAP2K60.46753806
106MAPKAPK30.46473518
107DAPK20.45816729
108PIM20.44882692
109BLK0.44215796
110NTRK20.42400240
111MAP2K40.41933990
112MARK10.41309077
113TTN0.40719377
114CDK140.40632131
115PRKCA0.40165071
116GRK10.39998575
117PRKD10.39665767
118NTRK10.39219915
119PRKG10.37132719
120PDK20.36503992
121MST1R0.36252352
122TIE10.35856439
123NEK10.35273032
124TRPM70.35254880
125CCNB10.34395486
126CDK11A0.33808646
127PRKCI0.33626616
128AURKB0.33616970
129CLK10.32578650
130PRKG20.31797460
131MAPK130.31743562
132CDK150.30911585
133FGFR10.30909053
134SYK0.30653078
135CDK180.29723806
136TXK0.29418793
137MAPK40.28067294
138SRPK10.27947095
139CAMK10.27828495
140EPHB20.27661683
141KDR0.27300981

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.72153385
2Parkinsons disease_Homo sapiens_hsa050125.68371254
3Alzheimers disease_Homo sapiens_hsa050104.32017732
4Huntingtons disease_Homo sapiens_hsa050163.84926062
5Ribosome_Homo sapiens_hsa030103.71599830
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.68640290
7Cardiac muscle contraction_Homo sapiens_hsa042603.30335983
8Fatty acid elongation_Homo sapiens_hsa000622.74504887
9Protein export_Homo sapiens_hsa030602.60159268
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43956188
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18822317
12Proteasome_Homo sapiens_hsa030502.08887969
13Collecting duct acid secretion_Homo sapiens_hsa049661.54580224
14Sulfur metabolism_Homo sapiens_hsa009201.52718932
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51022096
16Steroid biosynthesis_Homo sapiens_hsa001001.48143228
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47747474
18RNA polymerase_Homo sapiens_hsa030201.46584660
19Propanoate metabolism_Homo sapiens_hsa006401.39172450
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23164914
21Ether lipid metabolism_Homo sapiens_hsa005651.23061721
22RNA degradation_Homo sapiens_hsa030181.21143105
23Nitrogen metabolism_Homo sapiens_hsa009101.17899175
24Butanoate metabolism_Homo sapiens_hsa006501.17766207
25Fanconi anemia pathway_Homo sapiens_hsa034601.17340197
26Vibrio cholerae infection_Homo sapiens_hsa051101.16020590
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.13002996
28Mismatch repair_Homo sapiens_hsa034301.09681600
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07547587
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05391945
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03810681
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03152276
33Pyruvate metabolism_Homo sapiens_hsa006200.98058630
34Primary immunodeficiency_Homo sapiens_hsa053400.96985325
35DNA replication_Homo sapiens_hsa030300.96436902
36One carbon pool by folate_Homo sapiens_hsa006700.95727644
37Spliceosome_Homo sapiens_hsa030400.95099162
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94604108
39Arachidonic acid metabolism_Homo sapiens_hsa005900.92458951
40Rheumatoid arthritis_Homo sapiens_hsa053230.91035798
41* Metabolic pathways_Homo sapiens_hsa011000.89693221
42Linoleic acid metabolism_Homo sapiens_hsa005910.89337071
43Glutathione metabolism_Homo sapiens_hsa004800.88435416
44Histidine metabolism_Homo sapiens_hsa003400.83313804
45Sphingolipid metabolism_Homo sapiens_hsa006000.82185466
46Arginine and proline metabolism_Homo sapiens_hsa003300.80805318
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77208780
48Vitamin digestion and absorption_Homo sapiens_hsa049770.73483465
49Base excision repair_Homo sapiens_hsa034100.71160823
50Peroxisome_Homo sapiens_hsa041460.70297857
51Type I diabetes mellitus_Homo sapiens_hsa049400.69882927
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69108691
53Tyrosine metabolism_Homo sapiens_hsa003500.68612238
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67641496
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66470847
56Carbon metabolism_Homo sapiens_hsa012000.63674364
57Serotonergic synapse_Homo sapiens_hsa047260.61923882
58Caffeine metabolism_Homo sapiens_hsa002320.61186853
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60896615
60Sulfur relay system_Homo sapiens_hsa041220.60795697
61RNA transport_Homo sapiens_hsa030130.60343843
62Graft-versus-host disease_Homo sapiens_hsa053320.59952107
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58851504
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.58680727
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58564280
66Nicotine addiction_Homo sapiens_hsa050330.58115544
67Autoimmune thyroid disease_Homo sapiens_hsa053200.56941996
68Fatty acid metabolism_Homo sapiens_hsa012120.56757123
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55356029
70Phenylalanine metabolism_Homo sapiens_hsa003600.54019209
71Olfactory transduction_Homo sapiens_hsa047400.53294177
72Pyrimidine metabolism_Homo sapiens_hsa002400.52447619
73Fatty acid degradation_Homo sapiens_hsa000710.51362715
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50384621
75Folate biosynthesis_Homo sapiens_hsa007900.49999148
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48256700
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.47337456
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47138641
79Dilated cardiomyopathy_Homo sapiens_hsa054140.47131557
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46388169
81Chemical carcinogenesis_Homo sapiens_hsa052040.46235209
82Homologous recombination_Homo sapiens_hsa034400.45387760
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45116219
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44936671
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44669241
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44470884
87Allograft rejection_Homo sapiens_hsa053300.44243478
88GABAergic synapse_Homo sapiens_hsa047270.41669393
89Selenocompound metabolism_Homo sapiens_hsa004500.39686601
90Systemic lupus erythematosus_Homo sapiens_hsa053220.39204458
91Asthma_Homo sapiens_hsa053100.37816264
92Phototransduction_Homo sapiens_hsa047440.37580496
93beta-Alanine metabolism_Homo sapiens_hsa004100.37371308
94Purine metabolism_Homo sapiens_hsa002300.36566795
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.36429591
96Retinol metabolism_Homo sapiens_hsa008300.35629893
97Synaptic vesicle cycle_Homo sapiens_hsa047210.35300016
98Phagosome_Homo sapiens_hsa041450.34473476
99Morphine addiction_Homo sapiens_hsa050320.33849593
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30109291
101Taste transduction_Homo sapiens_hsa047420.29952843
102Antigen processing and presentation_Homo sapiens_hsa046120.28271118
103Fat digestion and absorption_Homo sapiens_hsa049750.27899747
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26486586
105Malaria_Homo sapiens_hsa051440.25889876
106Insulin secretion_Homo sapiens_hsa049110.25857057
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24929478
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.22442513
109Basal transcription factors_Homo sapiens_hsa030220.22343628
110Epstein-Barr virus infection_Homo sapiens_hsa051690.19663292
111Other glycan degradation_Homo sapiens_hsa005110.18018840
112Calcium signaling pathway_Homo sapiens_hsa040200.17514408
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.17130512
114Axon guidance_Homo sapiens_hsa043600.16540880
115Long-term depression_Homo sapiens_hsa047300.16204291
116Pancreatic secretion_Homo sapiens_hsa049720.16032804
117Vitamin B6 metabolism_Homo sapiens_hsa007500.14783022
118Tryptophan metabolism_Homo sapiens_hsa003800.14338492
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13658916
120Glutamatergic synapse_Homo sapiens_hsa047240.12968743
121Cholinergic synapse_Homo sapiens_hsa047250.10550987
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.10536780
123Nucleotide excision repair_Homo sapiens_hsa034200.09930142
124Cocaine addiction_Homo sapiens_hsa050300.09823694
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09042663
126Pentose phosphate pathway_Homo sapiens_hsa000300.08856516
127Regulation of autophagy_Homo sapiens_hsa041400.08798329
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08297366
129Gastric acid secretion_Homo sapiens_hsa049710.06377058
130Mineral absorption_Homo sapiens_hsa049780.06255341

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