NDUFA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the complex I 9kDa subunit family. Mammalian complex I of mitochondrial respiratory chain is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)9.38374722
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.38374722
3* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.05869161
4* respiratory electron transport chain (GO:0022904)7.66905554
5* electron transport chain (GO:0022900)7.48048730
6viral transcription (GO:0019083)5.53916897
7translational termination (GO:0006415)5.37589822
8chaperone-mediated protein transport (GO:0072321)5.27009084
9ATP biosynthetic process (GO:0006754)5.24463120
10ribosomal small subunit assembly (GO:0000028)5.11432747
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.96257844
12cotranslational protein targeting to membrane (GO:0006613)4.95459128
13protein targeting to ER (GO:0045047)4.87362067
14purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.77139314
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.75951991
16* hydrogen ion transmembrane transport (GO:1902600)4.74075595
17protein complex biogenesis (GO:0070271)4.72225939
18purine nucleoside triphosphate biosynthetic process (GO:0009145)4.70749574
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.69695412
20inner mitochondrial membrane organization (GO:0007007)4.68871019
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.68464579
22NADH dehydrogenase complex assembly (GO:0010257)4.68464579
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.68464579
24oxidative phosphorylation (GO:0006119)4.62955582
25protein localization to endoplasmic reticulum (GO:0070972)4.62933898
26proteasome assembly (GO:0043248)4.60332684
27translational elongation (GO:0006414)4.51405228
28mitochondrial respiratory chain complex assembly (GO:0033108)4.33616505
29ribosomal small subunit biogenesis (GO:0042274)4.24937319
30cellular protein complex disassembly (GO:0043624)4.22813081
31ribosomal large subunit biogenesis (GO:0042273)4.21945964
32ribonucleoside triphosphate biosynthetic process (GO:0009201)4.16538348
33* proton transport (GO:0015992)4.15902676
34tricarboxylic acid cycle (GO:0006099)4.11735468
35viral life cycle (GO:0019058)4.09886001
36* hydrogen transport (GO:0006818)4.09636765
37maturation of SSU-rRNA (GO:0030490)4.02677919
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.99456153
39translational initiation (GO:0006413)3.93055600
40sequestering of actin monomers (GO:0042989)3.90514158
41protein neddylation (GO:0045116)3.82639313
42NADH metabolic process (GO:0006734)3.78699837
43energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.77838554
44ATP hydrolysis coupled proton transport (GO:0015991)3.77838554
45regulation of oxidative phosphorylation (GO:0002082)3.74226499
46translation (GO:0006412)3.70914525
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70474812
48succinate metabolic process (GO:0006105)3.69048294
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.58842567
50termination of RNA polymerase III transcription (GO:0006386)3.58842567
51nucleoside triphosphate biosynthetic process (GO:0009142)3.58188605
52protein complex disassembly (GO:0043241)3.54169076
53regulation of acyl-CoA biosynthetic process (GO:0050812)3.52727265
54macromolecular complex disassembly (GO:0032984)3.43097607
55neuron cell-cell adhesion (GO:0007158)3.42959009
56aerobic respiration (GO:0009060)3.41815326
57dopamine transport (GO:0015872)3.41028011
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37971779
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33713858
60protein targeting to membrane (GO:0006612)3.32854259
61positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.32242890
62negative regulation of ligase activity (GO:0051352)3.32111418
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32111418
64regulation of cellular amino acid metabolic process (GO:0006521)3.27637724
65regulation of cofactor metabolic process (GO:0051193)3.26939769
66regulation of coenzyme metabolic process (GO:0051196)3.26939769
67regulation of cellular respiration (GO:0043457)3.21814998
68calcium-mediated signaling using intracellular calcium source (GO:0035584)3.21117244
69mitochondrial transport (GO:0006839)3.19413450
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19206601
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18738783
72neuronal action potential propagation (GO:0019227)3.12345933
73GTP biosynthetic process (GO:0006183)3.11505992
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09640652
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08693905
76purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.06114050
77purine nucleoside monophosphate biosynthetic process (GO:0009127)3.06114050
78cellular component biogenesis (GO:0044085)3.05041882
79* generation of precursor metabolites and energy (GO:0006091)3.04153498
80substantia nigra development (GO:0021762)3.03049231
81cullin deneddylation (GO:0010388)3.01119435
82regulation of mitochondrial translation (GO:0070129)3.00184728
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00080732
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00080732
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00080732
86regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.00038265
87regulation of cell communication by electrical coupling (GO:0010649)2.99897883
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99116862
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99116862
90establishment of integrated proviral latency (GO:0075713)2.96496032
91spliceosomal snRNP assembly (GO:0000387)2.96180041
92DNA damage response, detection of DNA damage (GO:0042769)2.96125694
93chromatin remodeling at centromere (GO:0031055)2.94653518
94nuclear-transcribed mRNA catabolic process (GO:0000956)2.94385919
95respiratory chain complex IV assembly (GO:0008535)2.94111812
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89611890
97CENP-A containing nucleosome assembly (GO:0034080)2.88379977
98regulation of protein kinase A signaling (GO:0010738)2.87854337
99tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87334776
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87334776
101protein targeting to mitochondrion (GO:0006626)2.86866602
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86684947
103signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86673794
104signal transduction involved in DNA damage checkpoint (GO:0072422)2.86673794
105negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.86200656
106signal transduction involved in cell cycle checkpoint (GO:0072395)2.85663504
107establishment of protein localization to mitochondrion (GO:0072655)2.84887705
108detection of calcium ion (GO:0005513)2.81146713
109cellular respiration (GO:0045333)2.80353568
110vocalization behavior (GO:0071625)2.77826106
111regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.77716390
112synaptic vesicle exocytosis (GO:0016079)2.77694504
113protein localization to mitochondrion (GO:0070585)2.77545351
114mRNA catabolic process (GO:0006402)2.76310311
115protein deneddylation (GO:0000338)2.74974812
116cellular ketone body metabolic process (GO:0046950)2.73734514
117purine ribonucleoside biosynthetic process (GO:0046129)2.72140372
118purine nucleoside biosynthetic process (GO:0042451)2.72140372
119positive regulation of ligase activity (GO:0051351)2.72053370
120oxaloacetate metabolic process (GO:0006107)2.71723107
121rRNA modification (GO:0000154)2.68317519
122regulation of dopamine metabolic process (GO:0042053)2.68257145
123regulation of catecholamine metabolic process (GO:0042069)2.68257145
124behavioral response to cocaine (GO:0048148)2.67707405
125ubiquinone biosynthetic process (GO:0006744)2.65730977
126quinone biosynthetic process (GO:1901663)2.65730977
127behavioral response to nicotine (GO:0035095)2.65724425
128regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.65528201
129fatty acid elongation (GO:0030497)2.65448527
130cytochrome complex assembly (GO:0017004)2.64583607
131intracellular protein transmembrane import (GO:0044743)2.62736187
132spliceosomal complex assembly (GO:0000245)2.60220435
133presynaptic membrane assembly (GO:0097105)2.58999377
134negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58156557
135nucleoside monophosphate biosynthetic process (GO:0009124)2.57627216
136protein-cofactor linkage (GO:0018065)2.56009948
137regulation of sulfur metabolic process (GO:0042762)2.55628219
138regulation of glutamate secretion (GO:0014048)2.55331958
139regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.54274499
140regulation of ubiquitin-protein transferase activity (GO:0051438)2.53839099
141response to epinephrine (GO:0071871)2.52003668
142transferrin transport (GO:0033572)2.51593596
143protein localization to synapse (GO:0035418)2.50479619
144positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47880530
145UTP biosynthetic process (GO:0006228)2.47478328
146ubiquinone metabolic process (GO:0006743)2.47352456
147presynaptic membrane organization (GO:0097090)2.46193869
148ketone body metabolic process (GO:1902224)2.45608152
149gamma-aminobutyric acid signaling pathway (GO:0007214)2.44895203
150protein localization to cilium (GO:0061512)2.42216833
151cellular response to epinephrine stimulus (GO:0071872)2.41735337
152ribonucleoside monophosphate biosynthetic process (GO:0009156)2.39897054
153neuron recognition (GO:0008038)2.36851617
154ferric iron transport (GO:0015682)2.36637755
155trivalent inorganic cation transport (GO:0072512)2.36637755
156UTP metabolic process (GO:0046051)2.35769080
157catecholamine transport (GO:0051937)2.35603753
158regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.35103541
159negative regulation of microtubule polymerization (GO:0031115)2.32598719
160positive regulation of synapse assembly (GO:0051965)2.32246930
161mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.0679655

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04049856
2TAF15_26573619_Chip-Seq_HEK293_Human3.23853199
3GBX2_23144817_ChIP-Seq_PC3_Human3.23722730
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.14424528
5* MYC_18555785_ChIP-Seq_MESCs_Mouse2.92933695
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.79501764
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66024683
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53367253
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48413931
10* ELK1_19687146_ChIP-ChIP_HELA_Human2.44366236
11VDR_22108803_ChIP-Seq_LS180_Human2.39089606
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.38028794
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34167673
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33126656
15* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18492944
16* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06814663
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.04393792
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.03524981
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00213505
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96247604
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94827993
22VDR_23849224_ChIP-Seq_CD4+_Human1.94352375
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93044246
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92529773
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92405051
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91270102
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91144843
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89376556
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86882062
30FUS_26573619_Chip-Seq_HEK293_Human1.84471577
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.81126222
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80502924
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79172702
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79172702
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.79117387
36REST_21632747_ChIP-Seq_MESCs_Mouse1.78007678
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77498098
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77337839
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76832501
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76827763
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76120542
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.73946999
43MYC_18940864_ChIP-ChIP_HL60_Human1.73850927
44XRN2_22483619_ChIP-Seq_HELA_Human1.73117378
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72969034
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72689443
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69108992
48* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68981649
49* TTF2_22483619_ChIP-Seq_HELA_Human1.68374689
50* FOXP3_21729870_ChIP-Seq_TREG_Human1.65638186
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64010628
52P300_19829295_ChIP-Seq_ESCs_Human1.62726123
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60576521
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60154444
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59329980
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57875503
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.57109890
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55699632
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47457192
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47193270
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45685308
62ZNF274_21170338_ChIP-Seq_K562_Hela1.44708069
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.44618418
64* DCP1A_22483619_ChIP-Seq_HELA_Human1.41896672
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.41835191
66* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40921633
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38801937
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.37890580
69ER_23166858_ChIP-Seq_MCF-7_Human1.35991855
70* ETS1_20019798_ChIP-Seq_JURKAT_Human1.35678435
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35486203
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34883499
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34612317
74* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34116603
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31714034
76HTT_18923047_ChIP-ChIP_STHdh_Human1.28753993
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.28235329
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27288942
79GABP_19822575_ChIP-Seq_HepG2_Human1.26348280
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26239872
81SMAD4_21799915_ChIP-Seq_A2780_Human1.25791834
82* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25616814
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24389766
84* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23499933
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.23127223
86IGF1R_20145208_ChIP-Seq_DFB_Human1.20930678
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.17563601
88* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17172807
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16398006
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.15835519
91* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15704864
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13959944
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.13024577
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12647201
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.12518857
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12276563
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12115686
98BCAT_22108803_ChIP-Seq_LS180_Human1.10821527
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08600613
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07435868
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.05602872
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05267566
103AR_21572438_ChIP-Seq_LNCaP_Human1.05058107
104TP53_22573176_ChIP-Seq_HFKS_Human1.03238375
105CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02757932
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.02400045
107IRF1_19129219_ChIP-ChIP_H3396_Human1.02319006
108* JUN_21703547_ChIP-Seq_K562_Human1.01922758
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01454230
110RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00475528
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.00220801
112RNF2_27304074_Chip-Seq_NSC_Mouse0.97765804
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97377708
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97304008
115* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96915009
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96842959
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96105399
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95758114
119* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95508026
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95238763
121ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94951860
122REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94258521
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94074754
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93042837
125SOX2_19829295_ChIP-Seq_ESCs_Human0.91819259
126NANOG_19829295_ChIP-Seq_ESCs_Human0.91819259
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91237718
128EWS_26573619_Chip-Seq_HEK293_Human0.91095105
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.91036545
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90741663
131YY1_21170310_ChIP-Seq_MESCs_Mouse0.90011865
132* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88466384
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.87858659
134AR_25329375_ChIP-Seq_VCAP_Human0.87366151
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85622740
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84863121
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82346494
138CBP_20019798_ChIP-Seq_JUKART_Human0.82346494
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82178693
140KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81414110
141RUNX2_22187159_ChIP-Seq_PCA_Human0.80528292
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79339560
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77491789
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76648528
145NANOG_18555785_ChIP-Seq_MESCs_Mouse0.72252938
146CTCF_18555785_ChIP-Seq_MESCs_Mouse0.72142912
147LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69090214
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68891834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.66498720
2MP0002837_dystrophic_cardiac_calcinosis4.45630810
3MP0001529_abnormal_vocalization3.24625806
4MP0006276_abnormal_autonomic_nervous2.77635252
5MP0006292_abnormal_olfactory_placode2.75822068
6MP0003136_yellow_coat_color2.67476852
7MP0000751_myopathy2.59403869
8MP0009379_abnormal_foot_pigmentation2.53216630
9MP0001968_abnormal_touch/_nociception2.52758428
10MP0002736_abnormal_nociception_after2.48404103
11MP0009745_abnormal_behavioral_response2.47176915
12MP0003635_abnormal_synaptic_transmissio2.42533250
13MP0006036_abnormal_mitochondrial_physio2.39522062
14MP0003646_muscle_fatigue2.38340070
15MP0004215_abnormal_myocardial_fiber2.37350542
16MP0009046_muscle_twitch2.34701797
17MP0002064_seizures2.31455681
18MP0004859_abnormal_synaptic_plasticity2.27265015
19MP0002272_abnormal_nervous_system2.22719595
20MP0001905_abnormal_dopamine_level2.22659743
21MP0002735_abnormal_chemical_nociception2.15860332
22MP0004270_analgesia2.07605870
23MP0001440_abnormal_grooming_behavior2.06513019
24MP0006035_abnormal_mitochondrial_morpho2.00657018
25MP0002572_abnormal_emotion/affect_behav1.93833619
26MP0004142_abnormal_muscle_tone1.93362067
27MP0004036_abnormal_muscle_relaxation1.91007994
28MP0002734_abnormal_mechanical_nocicepti1.90035696
29MP0002938_white_spotting1.87436040
30MP0002063_abnormal_learning/memory/cond1.87212701
31MP0001984_abnormal_olfaction1.84320647
32MP0003186_abnormal_redox_activity1.79756642
33MP0001486_abnormal_startle_reflex1.77814139
34MP0003011_delayed_dark_adaptation1.71926554
35MP0002822_catalepsy1.71855391
36MP0008789_abnormal_olfactory_epithelium1.66679489
37MP0002067_abnormal_sensory_capabilities1.65446025
38MP0005386_behavior/neurological_phenoty1.64287297
39MP0004924_abnormal_behavior1.64287297
40MP0001501_abnormal_sleep_pattern1.63798536
41MP0002733_abnormal_thermal_nociception1.63688799
42MP0000749_muscle_degeneration1.63340504
43MP0004145_abnormal_muscle_electrophysio1.63178265
44MP0001970_abnormal_pain_threshold1.62840026
45MP0008058_abnormal_DNA_repair1.59815955
46MP0010030_abnormal_orbit_morphology1.57876554
47MP0004084_abnormal_cardiac_muscle1.57513395
48MP0005330_cardiomyopathy1.48216492
49MP0003137_abnormal_impulse_conducting1.47086251
50MP0003329_amyloid_beta_deposits1.43859112
51MP0005423_abnormal_somatic_nervous1.42479301
52MP0001293_anophthalmia1.41392837
53MP0002653_abnormal_ependyma_morphology1.40367774
54MP0004484_altered_response_of1.38827366
55MP0005499_abnormal_olfactory_system1.38071754
56MP0005394_taste/olfaction_phenotype1.38071754
57MP0002102_abnormal_ear_morphology1.34883649
58MP0002184_abnormal_innervation1.34715933
59MP0008877_abnormal_DNA_methylation1.33010927
60MP0004085_abnormal_heartbeat1.29337690
61MP0002876_abnormal_thyroid_physiology1.29064266
62MP0003718_maternal_effect1.27553402
63MP0008875_abnormal_xenobiotic_pharmacok1.27274323
64MP0005535_abnormal_body_temperature1.27063185
65MP0000631_abnormal_neuroendocrine_gland1.26939831
66MP0003941_abnormal_skin_development1.25959640
67MP0008995_early_reproductive_senescence1.24448129
68MP0005084_abnormal_gallbladder_morpholo1.23928441
69MP0002234_abnormal_pharynx_morphology1.23136945
70MP0004043_abnormal_pH_regulation1.21961362
71MP0005620_abnormal_muscle_contractility1.21761761
72MP0003121_genomic_imprinting1.21532941
73MP0002972_abnormal_cardiac_muscle1.20867449
74MP0000566_synostosis1.18360510
75MP0002332_abnormal_exercise_endurance1.17733405
76MP0004133_heterotaxia1.16968413
77MP0002557_abnormal_social/conspecific_i1.13142185
78MP0001188_hyperpigmentation1.13119508
79MP0004147_increased_porphyrin_level1.13019524
80MP0003938_abnormal_ear_development1.10897565
81MP0000778_abnormal_nervous_system1.10773596
82MP0005253_abnormal_eye_physiology1.09409061
83MP0009697_abnormal_copulation1.09282448
84MP0002139_abnormal_hepatobiliary_system1.08207274
85MP0003787_abnormal_imprinting1.07901488
86MP0000747_muscle_weakness1.07794726
87MP0004957_abnormal_blastocyst_morpholog1.07483739
88MP0005551_abnormal_eye_electrophysiolog1.07167181
89MP0002066_abnormal_motor_capabilities/c1.06522820
90MP0001485_abnormal_pinna_reflex1.05719881
91MP0005360_urolithiasis1.05512687
92MP0005085_abnormal_gallbladder_physiolo1.03735499
93MP0008872_abnormal_physiological_respon1.02900320
94MP0002638_abnormal_pupillary_reflex1.02391747
95MP0003123_paternal_imprinting1.02244411
96MP0003806_abnormal_nucleotide_metabolis1.02074171
97MP0002106_abnormal_muscle_physiology0.98569629
98MP0002229_neurodegeneration0.98004701
99MP0000049_abnormal_middle_ear0.97882020
100MP0000026_abnormal_inner_ear0.97391705
101MP0000013_abnormal_adipose_tissue0.97289374
102MP0005332_abnormal_amino_acid0.95712186
103MP0008932_abnormal_embryonic_tissue0.95221478
104MP0003122_maternal_imprinting0.94392090
105MP0002277_abnormal_respiratory_mucosa0.93871157
106MP0010386_abnormal_urinary_bladder0.93716556
107MP0003890_abnormal_embryonic-extraembry0.92810224
108MP0002090_abnormal_vision0.92417525
109MP0001346_abnormal_lacrimal_gland0.92255673
110MP0005409_darkened_coat_color0.91667762
111MP0005379_endocrine/exocrine_gland_phen0.90696067
112MP0002751_abnormal_autonomic_nervous0.90554974
113MP0003567_abnormal_fetal_cardiomyocyte0.89145844
114MP0002882_abnormal_neuron_morphology0.88397174
115MP0004742_abnormal_vestibular_system0.87338717
116MP0003879_abnormal_hair_cell0.87276691
117MP0008775_abnormal_heart_ventricle0.86876035
118MP0003195_calcinosis0.86713548
119MP0005369_muscle_phenotype0.85641143
120MP0008569_lethality_at_weaning0.84772832
121MP0005646_abnormal_pituitary_gland0.83799283
122MP0006072_abnormal_retinal_apoptosis0.83464799
123MP0006138_congestive_heart_failure0.83008504
124MP0004130_abnormal_muscle_cell0.81862563
125MP0000230_abnormal_systemic_arterial0.81534357
126MP0005266_abnormal_metabolism0.81485454
127MP0003693_abnormal_embryo_hatching0.80444264
128MP0001286_abnormal_eye_development0.80129116
129MP0001963_abnormal_hearing_physiology0.79814694
130MP0000955_abnormal_spinal_cord0.79473478
131MP0005636_abnormal_mineral_homeostasis0.78850375
132MP0001502_abnormal_circadian_rhythm0.77772716
133MP0005195_abnormal_posterior_eye0.77086017
134MP0003315_abnormal_perineum_morphology0.77031179
135MP0002752_abnormal_somatic_nervous0.74980130
136MP0005385_cardiovascular_system_phenoty0.74972082
137MP0001544_abnormal_cardiovascular_syste0.74972082
138MP0001664_abnormal_digestion0.74207519
139MP0004087_abnormal_muscle_fiber0.74162245
140MP0001727_abnormal_embryo_implantation0.74031525
141MP0000372_irregular_coat_pigmentation0.73200698
142MP0000920_abnormal_myelination0.72410671

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.29196388
2Abnormal mitochondria in muscle tissue (HP:0008316)6.78885349
3Mitochondrial inheritance (HP:0001427)6.27056713
4Progressive macrocephaly (HP:0004481)6.25945526
5Acute encephalopathy (HP:0006846)6.25311299
6Increased CSF lactate (HP:0002490)5.46687589
7Hepatocellular necrosis (HP:0001404)5.40474421
8Hepatic necrosis (HP:0002605)4.89095165
9Cerebral edema (HP:0002181)4.78249374
10Increased hepatocellular lipid droplets (HP:0006565)4.70788950
11Lipid accumulation in hepatocytes (HP:0006561)4.44264090
12Increased intramyocellular lipid droplets (HP:0012240)4.19488842
13Abnormality of glycolysis (HP:0004366)4.10195898
14Increased serum pyruvate (HP:0003542)4.10195898
15Renal Fanconi syndrome (HP:0001994)3.98835203
16Lactic acidosis (HP:0003128)3.90278004
17Optic disc pallor (HP:0000543)3.83702379
18Exercise intolerance (HP:0003546)3.83493233
19Increased muscle lipid content (HP:0009058)3.81263758
20Respiratory failure (HP:0002878)3.80780732
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.80664856
22Abnormal number of erythroid precursors (HP:0012131)3.72451502
23Focal motor seizures (HP:0011153)3.59873612
24Leukodystrophy (HP:0002415)3.58005056
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.47662921
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.47662921
27Macrocytic anemia (HP:0001972)3.46524117
28Reticulocytopenia (HP:0001896)3.41877766
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.37662542
30Pheochromocytoma (HP:0002666)3.34208318
31Neuroendocrine neoplasm (HP:0100634)3.28492663
32Increased serum lactate (HP:0002151)3.26786142
33Muscle hypertrophy of the lower extremities (HP:0008968)2.99036148
34Myokymia (HP:0002411)2.97722589
353-Methylglutaconic aciduria (HP:0003535)2.95833924
36Calf muscle hypertrophy (HP:0008981)2.86822393
37Septo-optic dysplasia (HP:0100842)2.83617610
38Congenital, generalized hypertrichosis (HP:0004540)2.80734057
39Atonic seizures (HP:0010819)2.77925402
40Sudden death (HP:0001699)2.77415834
41Respiratory difficulties (HP:0002880)2.73852010
42X-linked dominant inheritance (HP:0001423)2.73170606
43Exertional dyspnea (HP:0002875)2.71758346
44Abnormality of renal resorption (HP:0011038)2.66313880
45Lethargy (HP:0001254)2.56797154
46Hyperventilation (HP:0002883)2.50149282
47CNS demyelination (HP:0007305)2.47967624
48Abnormality of urine glucose concentration (HP:0011016)2.41967284
49Glycosuria (HP:0003076)2.41967284
50Emotional lability (HP:0000712)2.41495610
51Conjunctival hamartoma (HP:0100780)2.41107589
52Abnormality of the labia minora (HP:0012880)2.37769777
53Hyperphosphaturia (HP:0003109)2.37766240
54Palpitations (HP:0001962)2.37680762
55Absence seizures (HP:0002121)2.32237159
56Pallor (HP:0000980)2.30368784
57Cerebral hemorrhage (HP:0001342)2.26685903
58Visual hallucinations (HP:0002367)2.24038111
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23880013
60Abnormality of alanine metabolism (HP:0010916)2.23880013
61Hyperalaninemia (HP:0003348)2.23880013
62Exercise-induced myalgia (HP:0003738)2.23411215
63Colon cancer (HP:0003003)2.22377666
64Absent septum pellucidum (HP:0001331)2.21696135
65Hyperglycinemia (HP:0002154)2.18598760
66Pancreatic fibrosis (HP:0100732)2.15901548
67Myotonia (HP:0002486)2.13744093
68Focal seizures (HP:0007359)2.12819467
69Molar tooth sign on MRI (HP:0002419)2.11404629
70Abnormality of midbrain morphology (HP:0002418)2.11404629
71Dialeptic seizures (HP:0011146)2.10779604
72Pancreatic cysts (HP:0001737)2.10608225
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.10354526
74Ragged-red muscle fibers (HP:0003200)2.05810476
75Vomiting (HP:0002013)2.04230007
76Cerebral hypomyelination (HP:0006808)2.02027748
77Anxiety (HP:0000739)2.00504391
78True hermaphroditism (HP:0010459)1.99362460
79Abnormal urine phosphate concentration (HP:0012599)1.98668918
80Aplastic anemia (HP:0001915)1.98163662
81Ketoacidosis (HP:0001993)1.98134119
82Epileptic encephalopathy (HP:0200134)1.97370499
83Myoglobinuria (HP:0002913)1.95981171
84Generalized aminoaciduria (HP:0002909)1.93275050
85Congenital primary aphakia (HP:0007707)1.92655312
86Abnormality of serum amino acid levels (HP:0003112)1.92227199
87Methylmalonic aciduria (HP:0012120)1.91732855
88Type I transferrin isoform profile (HP:0003642)1.91501577
89Abnormality of the calf musculature (HP:0001430)1.91173257
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90227375
91Dicarboxylic aciduria (HP:0003215)1.90227375
92Degeneration of anterior horn cells (HP:0002398)1.88451960
93Abnormality of the anterior horn cell (HP:0006802)1.88451960
94Stenosis of the external auditory canal (HP:0000402)1.87756100
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86155678
96Cholecystitis (HP:0001082)1.86045790
97Abnormal gallbladder physiology (HP:0012438)1.86045790
98Generalized tonic-clonic seizures (HP:0002069)1.85414882
99Abnormality of cells of the erythroid lineage (HP:0012130)1.85296221
100Optic nerve hypoplasia (HP:0000609)1.85107558
101Nephrogenic diabetes insipidus (HP:0009806)1.84303713
102Febrile seizures (HP:0002373)1.84258627
103Amniotic constriction ring (HP:0009775)1.82544266
104Abnormality of placental membranes (HP:0011409)1.82544266
105Abnormality of the septum pellucidum (HP:0007375)1.82399763
106Gliosis (HP:0002171)1.82256003
107Vaginal atresia (HP:0000148)1.82249834
108Hypothermia (HP:0002045)1.81429077
109Hyperglycinuria (HP:0003108)1.80514242
110Syncope (HP:0001279)1.79845976
111Delusions (HP:0000746)1.79282977
112Maternal diabetes (HP:0009800)1.78863133
113Limb dystonia (HP:0002451)1.78854172
114Genital tract atresia (HP:0001827)1.78010687
115Muscle stiffness (HP:0003552)1.77756244
116Methylmalonic acidemia (HP:0002912)1.76267008
117Exercise-induced muscle cramps (HP:0003710)1.76191158
118Renal tubular dysfunction (HP:0000124)1.75791932
119Progressive inability to walk (HP:0002505)1.75290483
120Abnormal pupillary function (HP:0007686)1.74538361
121Oral leukoplakia (HP:0002745)1.73876806
122Ketosis (HP:0001946)1.73844785
123Nephronophthisis (HP:0000090)1.73685466
124Sclerocornea (HP:0000647)1.71502887
125Retinal dysplasia (HP:0007973)1.70370118
126Progressive external ophthalmoplegia (HP:0000590)1.68579059
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67267132
128Degeneration of the lateral corticospinal tracts (HP:0002314)1.67267132
129Medial flaring of the eyebrow (HP:0010747)1.65967480
130Metabolic acidosis (HP:0001942)1.64060727
131Parakeratosis (HP:0001036)1.63877277
132Poor suck (HP:0002033)1.63386768
133CNS hypomyelination (HP:0003429)1.63301086
134Gait imbalance (HP:0002141)1.63201911
135Sensory axonal neuropathy (HP:0003390)1.62471806
136Nemaline bodies (HP:0003798)1.61322507
137Concave nail (HP:0001598)1.61308896
138Neoplasm of the peripheral nervous system (HP:0100007)1.61013548
139Blindness (HP:0000618)1.58884121
140Rhabdomyolysis (HP:0003201)1.58874925
141Partial duplication of thumb phalanx (HP:0009944)1.58840857
142Bilateral microphthalmos (HP:0007633)1.58555602
143Abnormality of methionine metabolism (HP:0010901)1.56340425
144Abnormality of serine family amino acid metabolism (HP:0010894)1.55724554
145Abnormality of glycine metabolism (HP:0010895)1.55724554
146Aplasia/Hypoplasia of the sacrum (HP:0008517)1.54870295
147Muscle fiber inclusion bodies (HP:0100299)1.54281446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.11036176
2VRK23.85555015
3NME13.21099370
4MYLK2.70998536
5CASK2.69562745
6MAP2K72.63496213
7MAP3K42.62484568
8PNCK2.52262165
9BUB12.44028852
10STK392.27132230
11EPHA42.27113267
12GRK52.21056495
13NTRK32.20131659
14ARAF2.19873824
15OXSR12.16146575
16CDC72.06191330
17STK162.02287177
18GRK72.02058281
19OBSCN2.00006086
20MAP2K41.99046131
21SRPK11.95020489
22WNK41.93989609
23ZAK1.92230160
24CDK191.82722925
25TNIK1.82479439
26PHKG21.76414370
27PHKG11.76414370
28MUSK1.68558457
29BCKDK1.66614311
30MINK11.62927601
31PDK41.62501103
32PDK31.62501103
33MAP4K21.54039374
34MARK11.45635113
35PLK21.44506646
36TLK11.34904702
37EIF2AK11.32763060
38NME21.30604884
39TRIM281.29103184
40CAMK2A1.27971814
41PLK31.27595874
42MAPK131.25856434
43MST41.25593575
44CAMK2B1.21407031
45WEE11.21026244
46RIPK41.19876058
47LIMK11.18257365
48CAMK2D1.17090868
49NUAK11.15193952
50MAP3K91.13162855
51DYRK31.06800490
52UHMK11.03719167
53DAPK11.03470660
54WNK31.02818214
55ADRBK21.02300103
56PLK41.02176366
57BCR1.00631100
58LMTK21.00101367
59BMPR20.97131944
60ADRBK10.96217554
61CAMK2G0.94900172
62PRKCG0.93128350
63BMPR1B0.92646293
64GRK10.90699412
65TTK0.89023346
66INSRR0.88715027
67TESK10.88284724
68PLK10.88063558
69PINK10.86998235
70PTK2B0.86500967
71MKNK10.85373015
72FGR0.85113022
73NTRK10.82623835
74PDK20.82573670
75TAF10.82307887
76CSNK1G30.80164121
77VRK10.79974978
78NTRK20.79311136
79EIF2AK30.78001290
80CDK50.77256094
81ROCK20.77127212
82TSSK60.76973527
83MAPKAPK50.76277014
84PRKCE0.76230569
85PAK30.72679690
86DAPK20.71713236
87AURKB0.70449229
88EPHB20.70133004
89PRKACA0.69733128
90GRK60.68583469
91CSNK1G20.68554389
92MAPK120.67961163
93DAPK30.66111556
94BRAF0.65818848
95MKNK20.64056531
96CSNK1A1L0.63900440
97MAP3K60.62448334
98TESK20.61935231
99AURKA0.61812140
100ILK0.61761724
101CSNK2A20.61373769
102CAMKK20.60692043
103FES0.57611600
104CSNK2A10.56961212
105CCNB10.56814795
106ABL20.56771937
107PIK3CA0.56756240
108CDK140.56473244
109BRSK10.55500215
110NEK10.55246105
111ERBB30.51907456
112KSR20.51834189
113PKN10.50944607
114RAF10.49648672
115PBK0.49305029
116CDK180.48758955
117DYRK20.48444747
118PIM20.48234492
119CHEK20.47243643
120CDK150.46101075
121TTN0.42467314
122CDK11A0.40967524
123STK240.40960860
124CAMK10.40571197
125MAPK40.39123060
126DYRK1A0.37802748
127CDK80.35906987
128KSR10.35537666
129CSNK1G10.35414842
130PRKACB0.35008333
131PAK60.34619053
132MAP2K10.32648889
133PRKCA0.31808436
134PRKG10.30798685
135WNK10.29111696

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.13149195
2Parkinsons disease_Homo sapiens_hsa050125.19558145
3Alzheimers disease_Homo sapiens_hsa050104.07017805
4Huntingtons disease_Homo sapiens_hsa050163.56975662
5Cardiac muscle contraction_Homo sapiens_hsa042603.21618761
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.16027847
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.08069499
8Collecting duct acid secretion_Homo sapiens_hsa049662.23104794
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08137574
10Mismatch repair_Homo sapiens_hsa034302.04344728
11Ribosome_Homo sapiens_hsa030102.00128586
12Proteasome_Homo sapiens_hsa030501.99906188
13Nicotine addiction_Homo sapiens_hsa050331.99499608
14Pyruvate metabolism_Homo sapiens_hsa006201.90317779
15Propanoate metabolism_Homo sapiens_hsa006401.88130860
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77008331
17Fatty acid elongation_Homo sapiens_hsa000621.75184280
18Homologous recombination_Homo sapiens_hsa034401.64477168
19Butanoate metabolism_Homo sapiens_hsa006501.59594713
20Synaptic vesicle cycle_Homo sapiens_hsa047211.58013199
21DNA replication_Homo sapiens_hsa030301.53752365
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41032205
23Spliceosome_Homo sapiens_hsa030401.38981953
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38094809
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38021361
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36235494
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33149448
28Protein export_Homo sapiens_hsa030601.32912552
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28312593
30Vibrio cholerae infection_Homo sapiens_hsa051101.27069984
31Sulfur metabolism_Homo sapiens_hsa009201.26180910
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26018278
33Nucleotide excision repair_Homo sapiens_hsa034201.23638613
34Carbon metabolism_Homo sapiens_hsa012001.22023668
35Folate biosynthesis_Homo sapiens_hsa007901.19777627
36GABAergic synapse_Homo sapiens_hsa047271.19161780
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13745701
38Taste transduction_Homo sapiens_hsa047421.13181969
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12070998
40RNA degradation_Homo sapiens_hsa030181.08849948
41Basal transcription factors_Homo sapiens_hsa030221.08069961
42Serotonergic synapse_Homo sapiens_hsa047261.00057823
43Fanconi anemia pathway_Homo sapiens_hsa034600.98837494
44Olfactory transduction_Homo sapiens_hsa047400.94326647
45Fatty acid degradation_Homo sapiens_hsa000710.93849904
46Morphine addiction_Homo sapiens_hsa050320.91925591
47Base excision repair_Homo sapiens_hsa034100.91610114
48Circadian entrainment_Homo sapiens_hsa047130.89333598
49Phenylalanine metabolism_Homo sapiens_hsa003600.88689769
50Amphetamine addiction_Homo sapiens_hsa050310.88283622
51Fatty acid metabolism_Homo sapiens_hsa012120.87884993
52Tyrosine metabolism_Homo sapiens_hsa003500.87462607
53RNA polymerase_Homo sapiens_hsa030200.85891907
54Glutamatergic synapse_Homo sapiens_hsa047240.85759749
55RNA transport_Homo sapiens_hsa030130.85337974
56Dopaminergic synapse_Homo sapiens_hsa047280.83247659
57Phototransduction_Homo sapiens_hsa047440.82627553
58Long-term potentiation_Homo sapiens_hsa047200.82254041
59* Metabolic pathways_Homo sapiens_hsa011000.80732442
60Peroxisome_Homo sapiens_hsa041460.80192815
61One carbon pool by folate_Homo sapiens_hsa006700.77207679
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76231320
63Calcium signaling pathway_Homo sapiens_hsa040200.74168488
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72654834
65Renin secretion_Homo sapiens_hsa049240.72292849
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68722186
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66204571
68Salivary secretion_Homo sapiens_hsa049700.65124370
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62565058
70Nitrogen metabolism_Homo sapiens_hsa009100.62228387
71beta-Alanine metabolism_Homo sapiens_hsa004100.62066480
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61929027
73Gastric acid secretion_Homo sapiens_hsa049710.59592509
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.58773090
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53863217
76Long-term depression_Homo sapiens_hsa047300.53554112
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50877316
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.50333794
79Oocyte meiosis_Homo sapiens_hsa041140.49249948
80Tryptophan metabolism_Homo sapiens_hsa003800.48829673
81Cholinergic synapse_Homo sapiens_hsa047250.48334430
82Dilated cardiomyopathy_Homo sapiens_hsa054140.48101662
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48075837
84Arginine and proline metabolism_Homo sapiens_hsa003300.48038191
85Biosynthesis of amino acids_Homo sapiens_hsa012300.47831955
86Insulin secretion_Homo sapiens_hsa049110.47245182
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47177821
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46691618
89Glutathione metabolism_Homo sapiens_hsa004800.46142550
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43750903
91Oxytocin signaling pathway_Homo sapiens_hsa049210.43215488
92Histidine metabolism_Homo sapiens_hsa003400.42982183
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42869933
94Non-homologous end-joining_Homo sapiens_hsa034500.39803342
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38670596
96Linoleic acid metabolism_Homo sapiens_hsa005910.38141336
97Regulation of autophagy_Homo sapiens_hsa041400.38028056
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37708808
99Chemical carcinogenesis_Homo sapiens_hsa052040.37288141
100Cocaine addiction_Homo sapiens_hsa050300.37042214
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36724826
102Retinol metabolism_Homo sapiens_hsa008300.35801788
103Cell cycle_Homo sapiens_hsa041100.33703897
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33174360
105Rheumatoid arthritis_Homo sapiens_hsa053230.32774309
106Arginine biosynthesis_Homo sapiens_hsa002200.32478145
107PPAR signaling pathway_Homo sapiens_hsa033200.32294652
108Steroid biosynthesis_Homo sapiens_hsa001000.30985649
109Vitamin digestion and absorption_Homo sapiens_hsa049770.30485984
110Selenocompound metabolism_Homo sapiens_hsa004500.30402712
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.29883172
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29648783
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29012679
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28972634
115Caffeine metabolism_Homo sapiens_hsa002320.28521790
116Pyrimidine metabolism_Homo sapiens_hsa002400.28128291
117Basal cell carcinoma_Homo sapiens_hsa052170.27881982
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.27333044
119Glucagon signaling pathway_Homo sapiens_hsa049220.27206762
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26762202
121Purine metabolism_Homo sapiens_hsa002300.24767125
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24408053
123Gap junction_Homo sapiens_hsa045400.24260274
124Alcoholism_Homo sapiens_hsa050340.24258705
125GnRH signaling pathway_Homo sapiens_hsa049120.19203486
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18196765
127Ether lipid metabolism_Homo sapiens_hsa005650.18175102
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14924909
129Phagosome_Homo sapiens_hsa041450.14788138
130Sulfur relay system_Homo sapiens_hsa041220.14434751
131Starch and sucrose metabolism_Homo sapiens_hsa005000.12983343

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