NDUFA4L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to parathyroid hormone (GO:0071107)9.07945663
2keratinization (GO:0031424)7.22895345
3cellular response to prostaglandin stimulus (GO:0071379)7.04843195
4sympathetic nervous system development (GO:0048485)7.03811197
5body morphogenesis (GO:0010171)6.93206885
6ganglion development (GO:0061548)6.87951694
7diacylglycerol metabolic process (GO:0046339)6.68565694
8dopaminergic neuron differentiation (GO:0071542)6.27318822
9enteric nervous system development (GO:0048484)6.22284557
10adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.22216648
11endothelial cell chemotaxis (GO:0035767)5.53194520
12response to prostaglandin E (GO:0034695)5.33833383
13cellular response to zinc ion (GO:0071294)5.33781121
14post-embryonic morphogenesis (GO:0009886)5.33227536
15negative regulation of multicellular organism growth (GO:0040015)5.30183627
16cAMP biosynthetic process (GO:0006171)5.26765309
17regulation of non-canonical Wnt signaling pathway (GO:2000050)5.25195402
18adrenergic receptor signaling pathway (GO:0071875)5.24603244
19ectodermal placode formation (GO:0060788)5.24108327
20positive regulation of cAMP-mediated signaling (GO:0043950)5.03360682
21response to BMP (GO:0071772)4.99824424
22cellular response to BMP stimulus (GO:0071773)4.99824424
23cell migration in hindbrain (GO:0021535)4.96381732
24metanephric mesenchyme development (GO:0072075)4.80795552
25vascular endothelial growth factor signaling pathway (GO:0038084)4.71348491
26cell migration involved in heart development (GO:0060973)4.57330216
27positive regulation of protein kinase C signaling (GO:0090037)4.53285332
28kidney mesenchyme development (GO:0072074)4.51817180
29positive regulation of vascular permeability (GO:0043117)4.49955932
30surfactant homeostasis (GO:0043129)4.39641615
31negative regulation of calcium ion transport into cytosol (GO:0010523)4.35524766
32establishment of skin barrier (GO:0061436)4.33849263
33endochondral ossification (GO:0001958)4.25286069
34replacement ossification (GO:0036075)4.25286069
35cell differentiation involved in metanephros development (GO:0072202)4.18604672
36venous blood vessel morphogenesis (GO:0048845)4.17899456
37metanephric tubule development (GO:0072170)4.17813422
38metanephric nephron tubule development (GO:0072234)4.17813422
39regulation of secondary heart field cardioblast proliferation (GO:0003266)4.16692772
40regulation of cardioblast proliferation (GO:0003264)4.16692772
41coronary vasculature morphogenesis (GO:0060977)4.16683010
42regulation of endothelial cell chemotaxis (GO:2001026)4.12502678
43peptide cross-linking (GO:0018149)4.10414505
44protein heterotrimerization (GO:0070208)4.07272880
45metanephric nephron epithelium development (GO:0072243)4.05298721
46response to prostaglandin (GO:0034694)3.97592483
47gamma-aminobutyric acid transport (GO:0015812)3.97551949
48atrioventricular valve morphogenesis (GO:0003181)3.94526070
49negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.87160989
50peptidyl-proline hydroxylation (GO:0019511)3.86649063
51protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)3.86228081
52heart valve formation (GO:0003188)3.85308951
53regulation of apoptotic process involved in morphogenesis (GO:1902337)3.81720460
54behavioral response to nicotine (GO:0035095)3.81579908
55keratan sulfate catabolic process (GO:0042340)3.79063317
56apoptotic process involved in morphogenesis (GO:0060561)3.77393153
57cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.74367213
58positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.72792508
59regulation of water loss via skin (GO:0033561)3.72348410
60positive regulation of p38MAPK cascade (GO:1900745)3.70491880
61metanephric epithelium development (GO:0072207)3.68892324
624-hydroxyproline metabolic process (GO:0019471)3.67939809
63nephron tubule development (GO:0072080)3.67745660
64collagen fibril organization (GO:0030199)3.64306893
65negative regulation of cytosolic calcium ion concentration (GO:0051481)3.64238699
66regulation of respiratory gaseous exchange (GO:0043576)3.62905983
67negative regulation of cell cycle arrest (GO:0071157)3.60089179
68tongue development (GO:0043586)3.58573572
69sarcoplasmic reticulum calcium ion transport (GO:0070296)3.56955879
70neural crest cell migration (GO:0001755)3.56657858
71regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.55625596
72hemidesmosome assembly (GO:0031581)3.54335056
73mesenchymal cell proliferation (GO:0010463)3.53895660
74endocardial cushion morphogenesis (GO:0003203)3.53821912
75regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.52152634
76negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.47748107
77keratinocyte differentiation (GO:0030216)3.46403829
78negative regulation of heart growth (GO:0061117)3.42767730
79negative regulation of cardiac muscle tissue growth (GO:0055022)3.42767730
80nephron epithelium development (GO:0072009)3.41107511
81chemical homeostasis within a tissue (GO:0048875)3.29930354
82cellular response to catecholamine stimulus (GO:0071870)3.29101256
83cellular response to monoamine stimulus (GO:0071868)3.29101256
84mesenchymal cell differentiation involved in kidney development (GO:0072161)3.29092403
85mesenchymal cell differentiation involved in renal system development (GO:2001012)3.29092403
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28680625
87bone development (GO:0060348)3.28625975
88regulation of p38MAPK cascade (GO:1900744)3.26336580
89negative regulation of striated muscle cell apoptotic process (GO:0010664)3.25626145
90protein maturation by protein folding (GO:0022417)3.25349247
91cochlea morphogenesis (GO:0090103)3.24551043
92renal tubule development (GO:0061326)3.23891650
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22965605
94pattern specification involved in kidney development (GO:0061004)3.21499533
95phosphate ion transmembrane transport (GO:0035435)3.17692763
96cardiac myofibril assembly (GO:0055003)3.17197064
97regulation of axon extension involved in axon guidance (GO:0048841)3.15227671
98regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.14353569
99positive regulation of cell cycle G2/M phase transition (GO:1902751)3.13383585
100positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.13383585
101negative regulation of catenin import into nucleus (GO:0035414)3.12606211
102planar cell polarity pathway involved in neural tube closure (GO:0090179)3.09219438
103genetic imprinting (GO:0071514)3.09108379
104regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.08908833
105ectoderm development (GO:0007398)3.04911956
106bone trabecula formation (GO:0060346)3.04838041
107camera-type eye morphogenesis (GO:0048593)3.04297922
108type B pancreatic cell proliferation (GO:0044342)3.02944137
109cellular response to ketone (GO:1901655)3.01233387
110mesenchyme morphogenesis (GO:0072132)2.99831837
111regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.99723311
112cyclic purine nucleotide metabolic process (GO:0052652)2.99553595
113basement membrane organization (GO:0071711)2.99369241
114cellular zinc ion homeostasis (GO:0006882)2.99064292
115protein hydroxylation (GO:0018126)2.98460898
116lung vasculature development (GO:0060426)2.97591813
117vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.97300896
118desmosome organization (GO:0002934)2.96759373
119positive regulation of transcription regulatory region DNA binding (GO:2000679)2.96323465
120skin development (GO:0043588)2.95614140
121regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94474567
122cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.92834707
123SMAD protein complex assembly (GO:0007183)2.92386651
124apoptotic process involved in development (GO:1902742)2.91424273
125peripheral nervous system axon ensheathment (GO:0032292)2.91258266
126myelination in peripheral nervous system (GO:0022011)2.91258266
127protein retention in ER lumen (GO:0006621)2.90718343
128heart valve morphogenesis (GO:0003179)2.89639429
129regulation of cAMP-mediated signaling (GO:0043949)2.88436263
130norepinephrine metabolic process (GO:0042415)2.86877036
131embryo implantation (GO:0007566)2.86194809
132nephron tubule formation (GO:0072079)2.85598806
133cartilage condensation (GO:0001502)2.85504525
134cell aggregation (GO:0098743)2.85504525
135positive regulation of glomerulus development (GO:0090193)2.85010981
136negative regulation of metanephros development (GO:0072217)2.84901487
137protein targeting to plasma membrane (GO:0072661)2.84408143
138cell communication by electrical coupling (GO:0010644)2.83592757
139adult heart development (GO:0007512)2.81104275
140skin morphogenesis (GO:0043589)2.80130156
141cyclic nucleotide biosynthetic process (GO:0009190)2.78957201
142regulation of neuron projection regeneration (GO:0070570)2.78045680
143regulation of axon regeneration (GO:0048679)2.78045680
144epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.77972120
145response to monoamine (GO:0071867)2.77391322
146response to catecholamine (GO:0071869)2.77391322
147mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.76999828
148cartilage morphogenesis (GO:0060536)2.75886038
149embryonic cranial skeleton morphogenesis (GO:0048701)2.75816172
150regulation of axon guidance (GO:1902667)2.74414086
151organic cation transport (GO:0015695)2.74261328
152embryonic hindlimb morphogenesis (GO:0035116)2.74160226
153sarcomere organization (GO:0045214)2.73415420
154regulation of cardiac muscle cell apoptotic process (GO:0010665)2.71982402
155cranial nerve morphogenesis (GO:0021602)2.71827866
156multicellular organismal water homeostasis (GO:0050891)2.70885482
157positive regulation of metanephros development (GO:0072216)2.69500806
158negative regulation of protein localization to cell surface (GO:2000009)2.65939243
159peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.65552440
160epidermal cell differentiation (GO:0009913)2.64874134
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61299821
162hair cycle (GO:0042633)2.58648340
163molting cycle (GO:0042303)2.58648340
164phosphate ion transport (GO:0006817)2.56507461
165myelin maintenance (GO:0043217)2.53594441
166epidermis development (GO:0008544)2.53251265
167dermatan sulfate biosynthetic process (GO:0030208)2.52928110
168glomerular filtration (GO:0003094)2.52911945
169retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51355511
170regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.47615199
171dermatan sulfate metabolic process (GO:0030205)2.47335466
172positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.46064094
173peptidyl-glutamic acid carboxylation (GO:0017187)2.43692801
174protein carboxylation (GO:0018214)2.43692801
175water homeostasis (GO:0030104)2.43047993
176cranial nerve structural organization (GO:0021604)2.43023988
177renal filtration (GO:0097205)2.42042639
178linoleic acid metabolic process (GO:0043651)2.40020085
179establishment of tissue polarity (GO:0007164)2.37298856
180establishment of planar polarity (GO:0001736)2.37298856
181Notch signaling involved in heart development (GO:0061314)2.37134489
182regulation of protein kinase C signaling (GO:0090036)2.36166513
183glomerular basement membrane development (GO:0032836)2.35191519
184collecting duct development (GO:0072044)2.34097352
185regulation of vascular permeability (GO:0043114)2.31827755
186chondroitin sulfate catabolic process (GO:0030207)2.31760157
187aorta morphogenesis (GO:0035909)2.25739998
188positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.24556434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.64523871
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.44732373
3ZNF263_19887448_ChIP-Seq_K562_Human3.93239998
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.69806002
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08348595
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.88821048
7CLOCK_20551151_ChIP-Seq_293T_Human2.69767506
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.69315103
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.24822999
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13381560
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13381560
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13267333
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.08544808
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.07082388
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04995974
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00482857
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99320123
18* KDM2B_26808549_Chip-Seq_K562_Human1.98421027
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.88340677
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86700975
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86607682
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86234085
23* LXR_22292898_ChIP-Seq_THP-1_Human1.84774571
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83352809
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78860677
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72140953
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.71681938
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70312899
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70236766
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69853665
31* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65654457
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.64741894
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64115911
34DROSHA_22980978_ChIP-Seq_HELA_Human1.61767308
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61235095
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60909301
37EZH2_22144423_ChIP-Seq_EOC_Human1.59416528
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.59210653
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58779912
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.58245858
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.58245858
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.58218752
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.57840310
44* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56083655
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55605084
46GATA1_19941826_ChIP-Seq_K562_Human1.55304401
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.53289917
48* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52317647
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49511195
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48831725
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43274756
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41357876
53SMC4_20622854_ChIP-Seq_HELA_Human1.40999239
54ATF3_27146783_Chip-Seq_COLON_Human1.40934164
55P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40508264
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40326488
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39371725
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.39135030
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36551298
60CTCF_20526341_ChIP-Seq_ESCs_Human1.36147075
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35852943
62* KDM2B_26808549_Chip-Seq_DND41_Human1.35825380
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34355682
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.33165925
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32946733
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.31301261
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30599392
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29713080
69* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29047019
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27228864
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26598629
72* RACK7_27058665_Chip-Seq_MCF-7_Human1.25895035
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25826404
74* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20345319
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20151471
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18842702
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17567580
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17404458
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16987182
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16771148
81* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15948887
82* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15732097
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15554764
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13351518
85TP53_22127205_ChIP-Seq_IMR90_Human1.13317143
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13155201
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12377105
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10866853
89* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09942644
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08044433
91* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06887272
92RXR_22158963_ChIP-Seq_LIVER_Mouse1.05858806
93* CREB1_26743006_Chip-Seq_LNCaP_Human1.05318698
94TET1_21490601_ChIP-Seq_MESCs_Mouse1.03979139
95CJUN_26792858_Chip-Seq_BT549_Human1.03873945
96CTCF_27219007_Chip-Seq_Bcells_Human1.02896854
97* TET1_21451524_ChIP-Seq_MESCs_Mouse1.02588234
98STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02304716
99* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01796016
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01008247
101* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00138907
102NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99920909
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99318108
104ISL1_27105846_Chip-Seq_CPCs_Mouse0.98557701
105WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98215598
106TP53_23651856_ChIP-Seq_MEFs_Mouse0.97693325
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97550921
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97541814
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97222037
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97202926
111SA1_27219007_Chip-Seq_Bcells_Human0.95797456
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95366654
113* TP63_22573176_ChIP-Seq_HFKS_Human0.95097014
114PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94969966
115CSB_26484114_Chip-Seq_FIBROBLAST_Human0.94718791
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94165284
117* RING1B_27294783_Chip-Seq_NPCs_Mouse0.93686524
118* KDM2B_26808549_Chip-Seq_JURKAT_Human0.93330110
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93040002
120P68_20966046_ChIP-Seq_HELA_Human0.92906434
121* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92713256
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.92539550
123EGR1_19032775_ChIP-ChIP_M12_Human0.91623732
124* SA1_27219007_Chip-Seq_ERYTHROID_Human0.90840515
125* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90647890
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90429787
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.90327309
128* CTCF_21964334_Chip-Seq_Bcells_Human0.90226952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting6.24648774
2MP0002638_abnormal_pupillary_reflex4.86765417
3MP0003787_abnormal_imprinting4.83911856
4MP0003122_maternal_imprinting4.22360844
5MP0005503_abnormal_tendon_morphology4.21833233
6MP0005275_abnormal_skin_tensile3.92277524
7MP0005645_abnormal_hypothalamus_physiol3.25465663
8MP0008438_abnormal_cutaneous_collagen3.21669998
9MP0008877_abnormal_DNA_methylation2.76574797
10MP0000751_myopathy2.64917298
11MP0005409_darkened_coat_color2.51507088
12MP0005377_hearing/vestibular/ear_phenot2.48826154
13MP0003878_abnormal_ear_physiology2.48826154
14MP0000003_abnormal_adipose_tissue2.46054455
15MP0003705_abnormal_hypodermis_morpholog2.41813574
16MP0004130_abnormal_muscle_cell2.30087497
17MP0000013_abnormal_adipose_tissue2.07289460
18MP0002060_abnormal_skin_morphology2.07113275
19MP0003646_muscle_fatigue2.03835340
20MP0005501_abnormal_skin_physiology2.03798087
21MP0003279_aneurysm2.01664742
22MP0000762_abnormal_tongue_morphology1.98805419
23MP0002909_abnormal_adrenal_gland1.95938975
24MP0003879_abnormal_hair_cell1.84352946
25MP0000749_muscle_degeneration1.82238690
26MP0006054_spinal_hemorrhage1.81331530
27MP0003121_genomic_imprinting1.76282169
28MP0004272_abnormal_basement_membrane1.74847096
29MP0003011_delayed_dark_adaptation1.73821632
30MP0000579_abnormal_nail_morphology1.73631134
31MP0004134_abnormal_chest_morphology1.73227913
32MP0009384_cardiac_valve_regurgitation1.71471978
33MP0001270_distended_abdomen1.68572512
34MP0010386_abnormal_urinary_bladder1.65169652
35MP0001958_emphysema1.64568482
36MP0006138_congestive_heart_failure1.63803726
37MP0009379_abnormal_foot_pigmentation1.63424915
38MP0000467_abnormal_esophagus_morphology1.60114731
39MP0004858_abnormal_nervous_system1.58371801
40MP0003453_abnormal_keratinocyte_physiol1.58085295
41MP0005257_abnormal_intraocular_pressure1.54175942
42MP0002127_abnormal_cardiovascular_syste1.52698550
43MP0003566_abnormal_cell_adhesion1.52593821
44MP0005375_adipose_tissue_phenotype1.45723840
45MP0002822_catalepsy1.40091079
46MP0009053_abnormal_anal_canal1.38622548
47MP0002282_abnormal_trachea_morphology1.36055920
48MP0005023_abnormal_wound_healing1.35420406
49MP0000767_abnormal_smooth_muscle1.34845275
50MP0005623_abnormal_meninges_morphology1.34327798
51MP0003942_abnormal_urinary_system1.33581683
52MP0000678_abnormal_parathyroid_gland1.33372703
53MP0002009_preneoplasia1.31028377
54MP0005423_abnormal_somatic_nervous1.29973849
55MP0010030_abnormal_orbit_morphology1.28879915
56MP0004084_abnormal_cardiac_muscle1.28691753
57MP0000163_abnormal_cartilage_morphology1.27867483
58MP0000049_abnormal_middle_ear1.26254709
59MP0001502_abnormal_circadian_rhythm1.25973384
60MP0002837_dystrophic_cardiac_calcinosis1.25559047
61MP0004085_abnormal_heartbeat1.25443948
62MP0000230_abnormal_systemic_arterial1.23893367
63MP0005508_abnormal_skeleton_morphology1.23667194
64MP0000534_abnormal_ureter_morphology1.23360521
65MP0003959_abnormal_lean_body1.20893534
66MP0002108_abnormal_muscle_morphology1.19858374
67MP0005670_abnormal_white_adipose1.18649707
68MP0001727_abnormal_embryo_implantation1.16219641
69MP0002796_impaired_skin_barrier1.15242806
70MP0005171_absent_coat_pigmentation1.13472008
71MP0003567_abnormal_fetal_cardiomyocyte1.07066697
72MP0010368_abnormal_lymphatic_system1.06051676
73MP0002249_abnormal_larynx_morphology1.03650692
74MP0004036_abnormal_muscle_relaxation1.03059164
75MP0003091_abnormal_cell_migration1.02933887
76MP0009250_abnormal_appendicular_skeleto1.01055618
77MP0004484_altered_response_of0.98961532
78MP0002933_joint_inflammation0.98805508
79MP0005666_abnormal_adipose_tissue0.97017947
80MP0004087_abnormal_muscle_fiber0.96634277
81MP0002115_abnormal_skeleton_extremities0.95961680
82MP0001756_abnormal_urination0.95334601
83MP0009672_abnormal_birth_weight0.94444587
84MP0005385_cardiovascular_system_phenoty0.94279118
85MP0001544_abnormal_cardiovascular_syste0.94279118
86MP0003941_abnormal_skin_development0.93167742
87MP0005330_cardiomyopathy0.92779013
88MP0002972_abnormal_cardiac_muscle0.92656167
89MP0008569_lethality_at_weaning0.92213958
90MP0005369_muscle_phenotype0.91550180
91MP0005647_abnormal_sex_gland0.91304424
92MP0001216_abnormal_epidermal_layer0.91303993
93MP0003385_abnormal_body_wall0.90233747
94MP0002751_abnormal_autonomic_nervous0.89838951
95MP0002106_abnormal_muscle_physiology0.86809691
96MP0009780_abnormal_chondrocyte_physiolo0.86760554
97MP0004885_abnormal_endolymph0.85823363
98MP0004381_abnormal_hair_follicle0.83977809
99MP0001348_abnormal_lacrimal_gland0.81906987
100MP0008775_abnormal_heart_ventricle0.81674077
101MP0010771_integument_phenotype0.81251184
102MP0001986_abnormal_taste_sensitivity0.81008500
103MP0005167_abnormal_blood-brain_barrier0.80607008
104MP0000566_synostosis0.80210864
105MP0003283_abnormal_digestive_organ0.78922345
106MP0000377_abnormal_hair_follicle0.78213379
107MP0001243_abnormal_dermal_layer0.78061109
108MP0000759_abnormal_skeletal_muscle0.75958221
109MP0001879_abnormal_lymphatic_vessel0.75398540
110MP0003137_abnormal_impulse_conducting0.75071862
111MP0010234_abnormal_vibrissa_follicle0.74522371
112MP0000266_abnormal_heart_morphology0.74264304
113MP0004233_abnormal_muscle_weight0.73434981
114MP0002295_abnormal_pulmonary_circulatio0.73047725
115MP0005197_abnormal_uvea_morphology0.71979181
116MP0002735_abnormal_chemical_nociception0.71887970
117MP0009703_decreased_birth_body0.71849870
118MP0000750_abnormal_muscle_regeneration0.71598680
119MP0005319_abnormal_enzyme/_coenzyme0.70834292
120MP0004859_abnormal_synaptic_plasticity0.70470466
121MP0005620_abnormal_muscle_contractility0.69072216
122MP0005595_abnormal_vascular_smooth0.66742747
123MP0002971_abnormal_brown_adipose0.65941073
124MP0004185_abnormal_adipocyte_glucose0.65417902
125MP0009931_abnormal_skin_appearance0.65318182
126MP0003136_yellow_coat_color0.65082353
127MP0000747_muscle_weakness0.65057012
128MP0010630_abnormal_cardiac_muscle0.64617142
129MP0002269_muscular_atrophy0.64073416
130MP0002109_abnormal_limb_morphology0.63896479
131MP0000538_abnormal_urinary_bladder0.63403742
132MP0002128_abnormal_blood_circulation0.62969902
133MP0003935_abnormal_craniofacial_develop0.62884748
134MP0002113_abnormal_skeleton_development0.62744359
135MP0002896_abnormal_bone_mineralization0.62434213
136MP0002098_abnormal_vibrissa_morphology0.62238143
137MP0002138_abnormal_hepatobiliary_system0.61655451
138MP0000026_abnormal_inner_ear0.61441308
139MP0002089_abnormal_postnatal_growth/wei0.61013364
140MP0002925_abnormal_cardiovascular_devel0.60509973
141MP0000249_abnormal_blood_vessel0.59476365
142MP0003638_abnormal_response/metabolism_0.59217805
143MP0001542_abnormal_bone_strength0.59208705
144MP0005164_abnormal_response_to0.58553649
145MP0002111_abnormal_tail_morphology0.57989242
146MP0001614_abnormal_blood_vessel0.55799174
147MP0003948_abnormal_gas_homeostasis0.55665271
148MP0003755_abnormal_palate_morphology0.55518231
149MP0000920_abnormal_myelination0.53636569
150MP0008770_decreased_survivor_rate0.53198632

Predicted human phenotypes

RankGene SetZ-score
1Malnutrition (HP:0004395)8.77082418
2Enlarged penis (HP:0000040)7.30317582
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.35060315
4Abnormality of nail color (HP:0100643)5.32331223
5Menstrual irregularities (HP:0000858)5.29172348
6Hyperthyroidism (HP:0000836)4.55219130
7Rhinitis (HP:0012384)4.53963168
8Hypercortisolism (HP:0001578)4.35569787
9Growth hormone excess (HP:0000845)4.23232895
10Steatorrhea (HP:0002570)4.21856050
11Macroorchidism (HP:0000053)4.21644009
12Agitation (HP:0000713)4.15538230
13Axonal loss (HP:0003447)4.11243352
14Soft skin (HP:0000977)4.04837296
15Striae distensae (HP:0001065)3.99740271
16Cranial hyperostosis (HP:0004437)3.99141550
17Thin bony cortex (HP:0002753)3.68475384
18Epiphyseal dysplasia (HP:0002656)3.67314057
19Testicular neoplasm (HP:0010788)3.60300079
20Hyperphosphatemia (HP:0002905)3.57763712
21Alopecia of scalp (HP:0002293)3.54979285
22Protrusio acetabuli (HP:0003179)3.52517675
23Palmoplantar hyperkeratosis (HP:0000972)3.49958109
24Polycythemia (HP:0001901)3.42538432
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.42508904
26Hyperparathyroidism (HP:0000843)3.41061548
27Nuclear cataract (HP:0100018)3.36873132
28Osteoarthritis (HP:0002758)3.36648264
29Premature rupture of membranes (HP:0001788)3.34823029
30Hypoplastic ischia (HP:0003175)3.29829428
31Hypoventilation (HP:0002791)3.26451131
32Fat malabsorption (HP:0002630)3.22411796
33Palmar hyperkeratosis (HP:0010765)3.18250599
34Broad metatarsal (HP:0001783)3.12882428
35Abnormality of calcium-phosphate metabolism (HP:0100530)3.08492618
36Restlessness (HP:0000711)2.93386241
37Mesomelia (HP:0003027)2.83745992
38Increased IgE level (HP:0003212)2.83722276
39Abnormality of the ischium (HP:0003174)2.83250771
40Ectopia lentis (HP:0001083)2.82419823
41Facial shape deformation (HP:0011334)2.80808543
42Potter facies (HP:0002009)2.80808543
43Osteopenia (HP:0000938)2.78658314
44Neonatal short-limb short stature (HP:0008921)2.78552839
45Type 1 muscle fiber predominance (HP:0003803)2.78210509
46Coronal craniosynostosis (HP:0004440)2.73456427
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72314913
48Thickened calvaria (HP:0002684)2.70612343
49Congenital ichthyosiform erythroderma (HP:0007431)2.69345449
50Plantar hyperkeratosis (HP:0007556)2.68183596
51Spinal rigidity (HP:0003306)2.66246070
52Irregular epiphyses (HP:0010582)2.60824191
53Flat capital femoral epiphysis (HP:0003370)2.59382207
54Segmental peripheral demyelination/remyelination (HP:0003481)2.57654028
55Thick nail (HP:0001805)2.56026748
56Hypotrichosis (HP:0001006)2.54500210
57Aortic aneurysm (HP:0004942)2.54225909
58Vitreoretinal degeneration (HP:0000655)2.51272831
59Joint stiffness (HP:0001387)2.49581589
60Popliteal pterygium (HP:0009756)2.49522670
61Increased connective tissue (HP:0009025)2.48809039
62Exercise-induced muscle cramps (HP:0003710)2.48414864
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.48194782
64Fragile skin (HP:0001030)2.47413338
65Wormian bones (HP:0002645)2.46272652
66Turricephaly (HP:0000262)2.46042106
67Atrophic scars (HP:0001075)2.45538183
68Ankle contracture (HP:0006466)2.42920040
69Exercise-induced myalgia (HP:0003738)2.39301278
70Small epiphyses (HP:0010585)2.33046819
71Hypoplasia of the iris (HP:0007676)2.31899918
72Abnormality of the anterior chamber (HP:0000593)2.31441560
73Erythroderma (HP:0001019)2.31074436
74Cholecystitis (HP:0001082)2.30306385
75Abnormal gallbladder physiology (HP:0012438)2.30306385
76Bladder diverticulum (HP:0000015)2.29192460
77Short metatarsal (HP:0010743)2.29084561
78Hyperextensible skin (HP:0000974)2.29003461
79Adrenal overactivity (HP:0002717)2.28823427
80Basal ganglia calcification (HP:0002135)2.28271563
81Vascular tortuosity (HP:0004948)2.28016698
82Cupped ribs (HP:0000887)2.27234369
83Erythema (HP:0010783)2.26633516
84Right ventricular cardiomyopathy (HP:0011663)2.22861877
85Hyporeflexia of lower limbs (HP:0002600)2.22654481
86Round ear (HP:0100830)2.21391371
87Overgrowth (HP:0001548)2.19154894
88Craniofacial hyperostosis (HP:0004493)2.18145757
89Arterial tortuosity (HP:0005116)2.17265192
90Distal lower limb muscle weakness (HP:0009053)2.16740635
91Increased variability in muscle fiber diameter (HP:0003557)2.16118072
92Pterygium (HP:0001059)2.16012110
93Focal segmental glomerulosclerosis (HP:0000097)2.15824333
94Abnormality of dentin (HP:0010299)2.15043912
95Short hallux (HP:0010109)2.13737134
96Venous insufficiency (HP:0005293)2.13524753
97Lip pit (HP:0100267)2.13088722
98Corneal erosion (HP:0200020)2.12745069
99Vertebral compression fractures (HP:0002953)2.11120013
100Chorioretinal atrophy (HP:0000533)2.10753600
101Muscle fiber splitting (HP:0003555)2.10381438
102Obstructive sleep apnea (HP:0002870)2.07352263
103Joint laxity (HP:0001388)2.06033354
104Rib fusion (HP:0000902)2.02795186
105Biconcave vertebral bodies (HP:0004586)2.02789295
106Mesangial abnormality (HP:0001966)2.01572789
107Slender build (HP:0001533)2.01411332
108Palmoplantar keratoderma (HP:0000982)2.00990438
109Blue sclerae (HP:0000592)2.00883951
110Asymmetric septal hypertrophy (HP:0001670)2.00832859
111Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.99921489
112Oral leukoplakia (HP:0002745)1.98900439
113Aplasia/Hypoplasia of the hallux (HP:0008362)1.98751876
114Limb-girdle muscle atrophy (HP:0003797)1.98718808
115Pulmonary artery stenosis (HP:0004415)1.97847751
116Genu recurvatum (HP:0002816)1.96897947
117Sudden death (HP:0001699)1.96455496
118Abnormality of the calf musculature (HP:0001430)1.94654720
119Lack of skin elasticity (HP:0100679)1.94026474
120Hemorrhage of the eye (HP:0011885)1.93988629
121Myotonia (HP:0002486)1.92706890
122Peritonitis (HP:0002586)1.90569324
123Pathologic fracture (HP:0002756)1.90568048
124Truncal obesity (HP:0001956)1.89931740
125Mitral regurgitation (HP:0001653)1.89027623
126Myoglobinuria (HP:0002913)1.88612507
127Precocious puberty (HP:0000826)1.88368449
128Intestinal polyposis (HP:0200008)1.87919202
129Neonatal onset (HP:0003623)1.86727796
130Exotropia (HP:0000577)1.86722231
131Follicular hyperkeratosis (HP:0007502)1.86226065
132Intestinal polyp (HP:0005266)1.84714783
133Abnormality of skeletal muscle fiber size (HP:0012084)1.84113019
134Mildly elevated creatine phosphokinase (HP:0008180)1.84041632
135Venous abnormality (HP:0002624)1.83939358
136Zonular cataract (HP:0010920)1.83200155
137Laryngomalacia (HP:0001601)1.81842710
138Abnormality of the phalanges of the 2nd finger (HP:0009541)1.81696611
139Annular pancreas (HP:0001734)1.80977734
140Decreased circulating renin level (HP:0003351)1.78764810
141Mitral stenosis (HP:0001718)1.78701413
142Absent eyelashes (HP:0000561)1.77734088
143Atrioventricular block (HP:0001678)1.77523698
144Infantile muscular hypotonia (HP:0008947)1.77103553
145Aortic regurgitation (HP:0001659)1.76275225
146Redundant skin (HP:0001582)1.75756047
147Ventricular tachycardia (HP:0004756)1.75721628
148Limited elbow extension (HP:0001377)1.75720747
149Patent foramen ovale (HP:0001655)1.75369395
150Bowel diverticulosis (HP:0005222)1.75188655
151Mitral valve prolapse (HP:0001634)1.75105953
152Abnormality of the intrinsic pathway (HP:0010989)1.74485262
153Mild short stature (HP:0003502)1.74229639
154Absent toe (HP:0010760)1.73152635
155Systemic lupus erythematosus (HP:0002725)1.72950108
156Round face (HP:0000311)1.72709898
157Abnormality of the axillary hair (HP:0100134)1.71820381
158Abnormality of secondary sexual hair (HP:0009888)1.71820381
159Aortic dissection (HP:0002647)1.71647936
160Flat acetabular roof (HP:0003180)1.71569496
161Delayed epiphyseal ossification (HP:0002663)1.69269180
162Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.68894048
163Goiter (HP:0000853)1.67232589
164Shallow orbits (HP:0000586)1.65271473
165Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.62548036
166Abnormality of femoral epiphyses (HP:0006499)1.62548036
167Metaphyseal cupping (HP:0003021)1.62508053
168Hip contracture (HP:0003273)1.60719478
169Short 1st metacarpal (HP:0010034)1.60176537
170Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.60176537
171Platyspondyly (HP:0000926)1.58389374
172Limited hip movement (HP:0008800)1.58020084
173Ulnar deviation of the wrist (HP:0003049)1.57626237
174Deviation of the hallux (HP:0010051)1.57349189
175Cerebral aneurysm (HP:0004944)1.57296574
176Waddling gait (HP:0002515)1.56595411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.21417248
2TRIB33.82771249
3PDGFRA3.57542876
4TGFBR13.01186897
5MAPK152.91063039
6EPHB22.89244238
7MAP3K32.72695534
8TTN2.72299754
9BMPR1B2.69321632
10PKN22.58302479
11PHKG22.26151472
12PHKG12.26151472
13ERN12.19183011
14DYRK32.16303111
15BUB12.06423539
16TESK12.03745132
17CDK82.00463035
18MAPKAPK31.92992237
19MAP2K61.92685793
20NLK1.89553096
21MAP3K61.74144013
22FER1.72959513
23MARK11.62759608
24LATS21.59780458
25STK241.58659266
26ICK1.57608363
27DMPK1.56382578
28FLT31.53777836
29CSNK1G31.51328727
30EEF2K1.48266957
31MAPK71.47681544
32INSRR1.44173393
33KIT1.38361462
34MET1.36880483
35CSNK1G21.35344433
36ARAF1.35177434
37NME11.34237205
38MYLK1.33837547
39OBSCN1.32915498
40MAP3K21.32049999
41ILK1.24218628
42LIMK11.22807742
43CSNK1G11.22371522
44EPHB11.19249194
45SIK21.18359247
46PRKD21.17734376
47STK381.16041500
48UHMK11.15187968
49ERBB31.14432482
50NTRK31.12730932
51MARK21.08493015
52PTK61.04332621
53MAP3K71.02082573
54PRKD11.00781911
55PRPF4B1.00089662
56TAOK10.98370668
57MAPKAPK50.97264175
58STK38L0.97219438
59RIPK10.97214139
60PAK30.95465363
61ABL20.93680847
62PKN10.93244328
63MTOR0.92381497
64PDGFRB0.92094137
65TGFBR20.91525858
66FGFR40.91207922
67RPS6KA20.90426218
68FGFR10.90291298
69GRK10.89723467
70PAK60.89575820
71MOS0.89267795
72PRKG20.88571208
73EPHA20.88550184
74LMTK20.88084446
75BMX0.87881179
76TIE10.87655854
77MAP3K90.83815664
78CASK0.83453558
79PAK20.82933025
80PINK10.81528476
81CSNK1A1L0.80431426
82NEK90.79543398
83PDPK10.76899292
84PLK20.76355997
85GSK3A0.75008267
86PTK2B0.73421272
87ROCK10.70628039
88AKT20.70388910
89KDR0.69645683
90EPHA30.68766762
91DYRK1B0.67513152
92WNK40.67253960
93DAPK30.65507661
94STK160.65446908
95SGK2230.64863866
96SGK4940.64863866
97WNK10.64343373
98PRKAA10.60027875
99MAP2K10.58834048
100MAP2K30.58699943
101CDC42BPA0.58307655
102BCKDK0.58305750
103CDK60.57953439
104GRK50.57252223
105ERBB40.57167566
106IRAK20.56952371
107PIM20.56597793
108SIK10.56494307
109ROCK20.54546731
110PTK20.54436512
111PAK10.52288752
112MAP2K20.52181184
113MAPK110.51441550
114MAPK40.51372130
115KSR20.50345617
116CDK50.49740468
117MAP3K100.49355691
118MAP3K110.48412917
119EPHA40.47647911
120PRKAA20.46709770
121MAPKAPK20.46554315
122MAP3K10.45299267
123RET0.45156094
124NTRK10.43655809
125PRKCI0.41478923
126LRRK20.41155848
127PRKCG0.40897027
128TRPM70.40838453
129PRKCH0.40821829
130HIPK20.40219772
131PDK40.40148939
132PDK30.40148939
133PIK3CG0.40083986
134ALK0.39199263
135RPS6KA40.38245081
136NEK10.37477842
137MST1R0.37179025
138PDK20.36534058
139PIK3CA0.36345607
140ADRBK10.36304534
141MAPK120.33833620
142TYRO30.31925839
143AKT30.31214234
144CAMK2G0.29241242
145PRKD30.28585088

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042602.91584025
2Dilated cardiomyopathy_Homo sapiens_hsa054142.81224080
3Vibrio cholerae infection_Homo sapiens_hsa051102.63519709
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.49682792
5Cocaine addiction_Homo sapiens_hsa050302.43117936
6Glycerolipid metabolism_Homo sapiens_hsa005612.42990033
7ECM-receptor interaction_Homo sapiens_hsa045122.41097331
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.23729912
9Renin secretion_Homo sapiens_hsa049242.08968290
10Ovarian steroidogenesis_Homo sapiens_hsa049132.02928098
11Amphetamine addiction_Homo sapiens_hsa050311.88674249
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.88528013
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85936219
14Sulfur relay system_Homo sapiens_hsa041221.80222139
15Phospholipase D signaling pathway_Homo sapiens_hsa040721.79778507
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.78590540
17Amoebiasis_Homo sapiens_hsa051461.72553261
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.71019513
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67848387
20Bile secretion_Homo sapiens_hsa049761.67259128
21Protein digestion and absorption_Homo sapiens_hsa049741.63196305
22Circadian rhythm_Homo sapiens_hsa047101.56761418
23Histidine metabolism_Homo sapiens_hsa003401.49743281
24Melanogenesis_Homo sapiens_hsa049161.47699450
25Basal cell carcinoma_Homo sapiens_hsa052171.46215987
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36135956
27Focal adhesion_Homo sapiens_hsa045101.35040893
28Thyroid hormone synthesis_Homo sapiens_hsa049181.33123250
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32808836
30Glucagon signaling pathway_Homo sapiens_hsa049221.32384386
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.32370081
32Gap junction_Homo sapiens_hsa045401.31523493
33Choline metabolism in cancer_Homo sapiens_hsa052311.31464589
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.30535015
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30449257
36Long-term depression_Homo sapiens_hsa047301.29875524
37Circadian entrainment_Homo sapiens_hsa047131.29086092
38Parkinsons disease_Homo sapiens_hsa050121.27752551
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27705407
40TGF-beta signaling pathway_Homo sapiens_hsa043501.26651873
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25913492
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25366745
43Arginine and proline metabolism_Homo sapiens_hsa003301.23279468
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.23093800
45Salivary secretion_Homo sapiens_hsa049701.21817816
46* Oxidative phosphorylation_Homo sapiens_hsa001901.17867735
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15003685
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12227726
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.12142582
50Biosynthesis of amino acids_Homo sapiens_hsa012301.09059362
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08865036
52Hippo signaling pathway_Homo sapiens_hsa043901.05405634
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04436799
54Insulin secretion_Homo sapiens_hsa049111.03139225
55Linoleic acid metabolism_Homo sapiens_hsa005911.01793404
56GnRH signaling pathway_Homo sapiens_hsa049121.00566593
57Arachidonic acid metabolism_Homo sapiens_hsa005901.00213754
58GABAergic synapse_Homo sapiens_hsa047270.99574023
59Gastric acid secretion_Homo sapiens_hsa049710.98038672
60Dopaminergic synapse_Homo sapiens_hsa047280.97454376
61Estrogen signaling pathway_Homo sapiens_hsa049150.97032272
62VEGF signaling pathway_Homo sapiens_hsa043700.96174070
63Axon guidance_Homo sapiens_hsa043600.95182257
64Alzheimers disease_Homo sapiens_hsa050100.91887272
65Notch signaling pathway_Homo sapiens_hsa043300.86792776
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86350157
67* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84912355
68Prion diseases_Homo sapiens_hsa050200.84672653
69Carbon metabolism_Homo sapiens_hsa012000.84663773
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84125431
71Arginine biosynthesis_Homo sapiens_hsa002200.83199942
72Glutamatergic synapse_Homo sapiens_hsa047240.81787164
73Oxytocin signaling pathway_Homo sapiens_hsa049210.81471071
74Folate biosynthesis_Homo sapiens_hsa007900.81385420
75Lysine degradation_Homo sapiens_hsa003100.81226159
76Hedgehog signaling pathway_Homo sapiens_hsa043400.80935207
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80304225
78Pentose phosphate pathway_Homo sapiens_hsa000300.78384395
79Alcoholism_Homo sapiens_hsa050340.78033301
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77818116
81Sphingolipid metabolism_Homo sapiens_hsa006000.77787929
82Adherens junction_Homo sapiens_hsa045200.76617002
83Thyroid cancer_Homo sapiens_hsa052160.76160694
84Platelet activation_Homo sapiens_hsa046110.75785101
85Proteoglycans in cancer_Homo sapiens_hsa052050.74661598
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72728927
87Nitrogen metabolism_Homo sapiens_hsa009100.72646696
88Ras signaling pathway_Homo sapiens_hsa040140.71902567
89Serotonergic synapse_Homo sapiens_hsa047260.71280331
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71262644
91Phenylalanine metabolism_Homo sapiens_hsa003600.70508711
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69608514
93Renal cell carcinoma_Homo sapiens_hsa052110.67595921
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67451201
95Galactose metabolism_Homo sapiens_hsa000520.67289184
96Calcium signaling pathway_Homo sapiens_hsa040200.66891923
97Synaptic vesicle cycle_Homo sapiens_hsa047210.65212567
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64732423
99Pathways in cancer_Homo sapiens_hsa052000.63908293
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63309667
101PPAR signaling pathway_Homo sapiens_hsa033200.63238516
102HIF-1 signaling pathway_Homo sapiens_hsa040660.62439211
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61667989
104Complement and coagulation cascades_Homo sapiens_hsa046100.61397085
105Ether lipid metabolism_Homo sapiens_hsa005650.60770164
106Taste transduction_Homo sapiens_hsa047420.60132899
107mTOR signaling pathway_Homo sapiens_hsa041500.59972137
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.58960395
109Morphine addiction_Homo sapiens_hsa050320.57397472
110AMPK signaling pathway_Homo sapiens_hsa041520.56584195
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56014132
112Huntingtons disease_Homo sapiens_hsa050160.53404413
113Rap1 signaling pathway_Homo sapiens_hsa040150.51656993
114cAMP signaling pathway_Homo sapiens_hsa040240.50949692
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50642276
116Glioma_Homo sapiens_hsa052140.50506059
117Cholinergic synapse_Homo sapiens_hsa047250.49617263
118Wnt signaling pathway_Homo sapiens_hsa043100.46995790
119Tyrosine metabolism_Homo sapiens_hsa003500.45500720
120Propanoate metabolism_Homo sapiens_hsa006400.45011498
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44837778
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44569359
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43176160
124Pancreatic secretion_Homo sapiens_hsa049720.38798981
125Starch and sucrose metabolism_Homo sapiens_hsa005000.38076210
126Insulin signaling pathway_Homo sapiens_hsa049100.37115114
127Dorso-ventral axis formation_Homo sapiens_hsa043200.35356141
128Tight junction_Homo sapiens_hsa045300.35254849
129Fructose and mannose metabolism_Homo sapiens_hsa000510.34192315
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34008331
131Bladder cancer_Homo sapiens_hsa052190.33723755

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