NDUFA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)9.88165017
2ATP synthesis coupled proton transport (GO:0015986)9.88165017
3* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.41925945
4* respiratory electron transport chain (GO:0022904)8.61307514
5* electron transport chain (GO:0022900)8.38983724
6ATP biosynthetic process (GO:0006754)5.57835665
7oxidative phosphorylation (GO:0006119)5.46492504
8protein complex biogenesis (GO:0070271)5.18388666
9hydrogen ion transmembrane transport (GO:1902600)5.11985694
10purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.04242443
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.01747930
12NADH dehydrogenase complex assembly (GO:0010257)5.01747930
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.01747930
14purine nucleoside triphosphate biosynthetic process (GO:0009145)4.96144144
15inner mitochondrial membrane organization (GO:0007007)4.90481312
16mitochondrial respiratory chain complex assembly (GO:0033108)4.76515962
17chaperone-mediated protein transport (GO:0072321)4.69089975
18tricarboxylic acid cycle (GO:0006099)4.67148157
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.57875467
20protein K11-linked deubiquitination (GO:0035871)4.46742363
21proton transport (GO:0015992)4.42600410
22ribonucleoside triphosphate biosynthetic process (GO:0009201)4.38965281
23positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.38532120
24hydrogen transport (GO:0006818)4.35301497
25regulation of oxidative phosphorylation (GO:0002082)4.06292719
26protein neddylation (GO:0045116)4.00819102
27aerobic respiration (GO:0009060)3.89882893
28regulation of acyl-CoA biosynthetic process (GO:0050812)3.89565471
29regulation of mitochondrial translation (GO:0070129)3.80726702
30regulation of cell communication by electrical coupling (GO:0010649)3.80195398
31nucleoside triphosphate biosynthetic process (GO:0009142)3.78527072
32NADH metabolic process (GO:0006734)3.70675971
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.70029671
34regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.69492573
35negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.63068184
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.61602324
37DNA double-strand break processing (GO:0000729)3.60321965
38regulation of coenzyme metabolic process (GO:0051196)3.57988148
39regulation of cofactor metabolic process (GO:0051193)3.57988148
40sarcomere organization (GO:0045214)3.54797762
41quinone biosynthetic process (GO:1901663)3.52127660
42ubiquinone biosynthetic process (GO:0006744)3.52127660
43ATP hydrolysis coupled proton transport (GO:0015991)3.49008552
44energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.49008552
45dopamine transport (GO:0015872)3.45582384
46synaptic vesicle maturation (GO:0016188)3.40940717
47regulation of cellular respiration (GO:0043457)3.38151901
48regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.35004395
49mitochondrial transport (GO:0006839)3.34538339
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.33957679
51succinate metabolic process (GO:0006105)3.31087662
52* generation of precursor metabolites and energy (GO:0006091)3.30965504
53purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.27260818
54purine nucleoside monophosphate biosynthetic process (GO:0009127)3.27260818
55serotonin receptor signaling pathway (GO:0007210)3.26627813
56respiratory chain complex IV assembly (GO:0008535)3.24368499
57neuronal action potential propagation (GO:0019227)3.22725969
58ubiquinone metabolic process (GO:0006743)3.18516919
59cytochrome complex assembly (GO:0017004)3.17478982
60GTP biosynthetic process (GO:0006183)3.16666164
61regulation of relaxation of muscle (GO:1901077)3.15833741
62heart contraction (GO:0060047)3.14408034
63heart process (GO:0003015)3.14408034
64positive regulation of mitochondrial fission (GO:0090141)3.12700038
65water-soluble vitamin biosynthetic process (GO:0042364)3.09867289
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08032152
67sarcoplasmic reticulum calcium ion transport (GO:0070296)3.07807364
68negative regulation of heart rate (GO:0010459)3.06431987
69cellular respiration (GO:0045333)3.06315968
70detection of calcium ion (GO:0005513)3.04908911
71muscle filament sliding (GO:0030049)3.02369915
72actin-myosin filament sliding (GO:0033275)3.02369915
73cardiac muscle contraction (GO:0060048)2.99351398
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97625335
75regulation of short-term neuronal synaptic plasticity (GO:0048172)2.95673716
76cardiac myofibril assembly (GO:0055003)2.95352376
77ketone body metabolic process (GO:1902224)2.94797049
78establishment of protein localization to mitochondrion (GO:0072655)2.94773071
79protein targeting to mitochondrion (GO:0006626)2.94405101
80negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.94192778
81negative regulation of calcium ion transmembrane transport (GO:1903170)2.94192778
82regulation of actin filament-based movement (GO:1903115)2.89705926
83negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.89369851
84glycerophospholipid catabolic process (GO:0046475)2.88533064
85regulation of appetite (GO:0032098)2.88501910
86calcium-mediated signaling using intracellular calcium source (GO:0035584)2.87491083
87cullin deneddylation (GO:0010388)2.86626412
88protein localization to mitochondrion (GO:0070585)2.86003507
89regulation of catecholamine metabolic process (GO:0042069)2.83347281
90regulation of dopamine metabolic process (GO:0042053)2.83347281
91righting reflex (GO:0060013)2.82456389
92myofibril assembly (GO:0030239)2.79634584
93purine nucleoside biosynthetic process (GO:0042451)2.79380986
94purine ribonucleoside biosynthetic process (GO:0046129)2.79380986
95cellular ketone body metabolic process (GO:0046950)2.77034082
96protein localization to cilium (GO:0061512)2.71318597
97protein-cofactor linkage (GO:0018065)2.70618575
98negative regulation of protein localization to cell surface (GO:2000009)2.69780213
99response to epinephrine (GO:0071871)2.66904547
100regulation of sulfur metabolic process (GO:0042762)2.66853999
101regulation of glucokinase activity (GO:0033131)2.63399723
102regulation of hexokinase activity (GO:1903299)2.63399723
103regulation of protein kinase A signaling (GO:0010738)2.62391977
104positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62053082
105proline transport (GO:0015824)2.61219200
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.60610117
107regulation of membrane repolarization (GO:0060306)2.60249279
108protein deneddylation (GO:0000338)2.59704517
109synaptic transmission, glutamatergic (GO:0035249)2.59682992
110regulation of striated muscle contraction (GO:0006942)2.59480368
111neuron-neuron synaptic transmission (GO:0007270)2.59068047
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58990875
113neuron cell-cell adhesion (GO:0007158)2.58679476
114cellular response to epinephrine stimulus (GO:0071872)2.58345681
115amino acid salvage (GO:0043102)2.57463840
116L-methionine salvage (GO:0071267)2.57463840
117L-methionine biosynthetic process (GO:0071265)2.57463840
118substantia nigra development (GO:0021762)2.57175451
119gamma-aminobutyric acid transport (GO:0015812)2.54311407
120negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54149286
121ribosomal small subunit biogenesis (GO:0042274)2.52930686
122ribonucleoprotein complex disassembly (GO:0032988)2.52709888
123ribonucleoside monophosphate biosynthetic process (GO:0009156)2.52414003
124positive regulation of heart rate (GO:0010460)2.52169406
125ventricular cardiac muscle cell action potential (GO:0086005)2.51439407
126cardiac muscle tissue morphogenesis (GO:0055008)2.51328867
127regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48848374
128regulation of sarcomere organization (GO:0060297)2.48398109
129UTP biosynthetic process (GO:0006228)2.48355283
130branched-chain amino acid catabolic process (GO:0009083)2.47522147
131reflex (GO:0060004)2.47469578
132striated muscle contraction (GO:0006941)2.47194901
133proteasome assembly (GO:0043248)2.46485982
134neurotransmitter uptake (GO:0001504)2.45020486
135protein K6-linked ubiquitination (GO:0085020)2.44085879
136startle response (GO:0001964)2.43913252
137glycosphingolipid biosynthetic process (GO:0006688)2.40909205
138presynaptic membrane assembly (GO:0097105)2.39115386
139detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39041800
140pyrimidine nucleobase catabolic process (GO:0006208)2.38991765
141presynaptic membrane organization (GO:0097090)2.38617358
142C4-dicarboxylate transport (GO:0015740)2.38236879
143aspartate family amino acid catabolic process (GO:0009068)2.36567011
144behavioral response to nicotine (GO:0035095)2.36222780
145platelet dense granule organization (GO:0060155)2.36080637
146synaptic vesicle exocytosis (GO:0016079)2.33068650
147organelle disassembly (GO:1903008)2.32388372
148G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30406896
149maturation of 5.8S rRNA (GO:0000460)2.27419035
150regulation of cilium movement (GO:0003352)2.26459945
151regulation of action potential (GO:0098900)2.25772140
152nucleobase catabolic process (GO:0046113)2.25755861
153neurotransmitter secretion (GO:0007269)2.25266905
154regulation of synaptic vesicle exocytosis (GO:2000300)2.25254715
155anterograde synaptic vesicle transport (GO:0048490)2.24120319
156positive regulation of potassium ion transmembrane transport (GO:1901381)2.24080862
157nonmotile primary cilium assembly (GO:0035058)2.22494339
158gamma-aminobutyric acid signaling pathway (GO:0007214)2.21412092
159negative regulation of cation channel activity (GO:2001258)2.20984044
160retinal cone cell development (GO:0046549)2.20833072
161glutamate secretion (GO:0014047)2.20617770
162mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.4642947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.36331524
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.45220602
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.23492702
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01128443
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94315344
6GBX2_23144817_ChIP-Seq_PC3_Human2.80388532
7VDR_22108803_ChIP-Seq_LS180_Human2.79255143
8TAF15_26573619_Chip-Seq_HEK293_Human2.50413555
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43826004
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.25586829
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.13481769
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09003597
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09001288
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06697932
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02334762
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01784708
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01163458
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96377912
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94105403
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.85436254
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81630949
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81024142
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79867128
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77926153
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77599193
26FUS_26573619_Chip-Seq_HEK293_Human1.73783956
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72901090
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72060442
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71766529
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.69270445
31ZNF274_21170338_ChIP-Seq_K562_Hela1.61741893
32* SRF_21415370_ChIP-Seq_HL-1_Mouse1.61228756
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60683386
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.60142295
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59079579
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58918479
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58711249
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58554015
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56995697
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56402548
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55836306
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.51384622
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.49785921
44FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.48475914
45* REST_21632747_ChIP-Seq_MESCs_Mouse1.47858859
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46673732
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45905250
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45905250
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.45527392
50P300_19829295_ChIP-Seq_ESCs_Human1.44556667
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43739599
52* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42467548
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41907166
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.35838561
55RNF2_27304074_Chip-Seq_NSC_Mouse1.35413405
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35121537
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34017690
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33714798
59* TP53_22573176_ChIP-Seq_HFKS_Human1.33438670
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33178517
61STAT3_23295773_ChIP-Seq_U87_Human1.32781168
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32575171
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.32446947
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32320998
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30086998
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29425358
67ER_23166858_ChIP-Seq_MCF-7_Human1.28094000
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27621324
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.27606210
70P53_22387025_ChIP-Seq_ESCs_Mouse1.26950144
71TCF4_23295773_ChIP-Seq_U87_Human1.26817346
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26156022
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.25645185
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.25595856
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24036158
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.23515021
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23221763
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.22473076
79MYC_18940864_ChIP-ChIP_HL60_Human1.22449615
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22094373
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.21377572
82VDR_23849224_ChIP-Seq_CD4+_Human1.21144315
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18879169
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18032867
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17996102
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17327568
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11933690
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.11337075
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.11156064
90TCF4_22108803_ChIP-Seq_LS180_Human1.11086797
91TAL1_26923725_Chip-Seq_HPCs_Mouse1.09728766
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09375408
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09229779
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.08990940
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08942254
96* SMAD4_21799915_ChIP-Seq_A2780_Human1.08490867
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07995826
98IGF1R_20145208_ChIP-Seq_DFB_Human1.07416522
99JUN_21703547_ChIP-Seq_K562_Human1.07202939
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07180055
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05821265
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05318586
103SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04794953
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04369684
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04365713
106* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04207815
107* RUNX2_22187159_ChIP-Seq_PCA_Human1.04202315
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.04196429
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.03545468
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.03504337
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02069157
112* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01201540
113HTT_18923047_ChIP-ChIP_STHdh_Human0.98963850
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.96989540
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.92606931
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92239089
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91977985
118BCAT_22108803_ChIP-Seq_LS180_Human0.91350364
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89081500
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.88659810
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88475406
122FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88460567
123RNF2_27304074_Chip-Seq_ESCs_Mouse0.87324096
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85939766
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85715797
126NANOG_19829295_ChIP-Seq_ESCs_Human0.85170021
127SOX2_19829295_ChIP-Seq_ESCs_Human0.85170021
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84575679
129ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83248862
130AR_25329375_ChIP-Seq_VCAP_Human0.82781092
131DCP1A_22483619_ChIP-Seq_HELA_Human0.80919054
132EWS_26573619_Chip-Seq_HEK293_Human0.80235495
133CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80094686
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.79204055
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78889568
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78499904
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78346123
138CBP_20019798_ChIP-Seq_JUKART_Human0.78346123
139ELK1_19687146_ChIP-ChIP_HELA_Human0.78003112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.45459300
2MP0003880_abnormal_central_pattern4.21651528
3MP0003646_muscle_fatigue4.03507699
4MP0000751_myopathy3.39285324
5MP0004215_abnormal_myocardial_fiber3.32861716
6MP0001529_abnormal_vocalization3.07156630
7MP0004084_abnormal_cardiac_muscle2.99803203
8MP0004036_abnormal_muscle_relaxation2.72200076
9MP0002822_catalepsy2.60186289
10MP0006276_abnormal_autonomic_nervous2.56535121
11MP0000749_muscle_degeneration2.55789893
12MP0006036_abnormal_mitochondrial_physio2.52788631
13MP0009379_abnormal_foot_pigmentation2.44962832
14MP0005330_cardiomyopathy2.27663181
15MP0004484_altered_response_of2.26359195
16MP0002736_abnormal_nociception_after2.18301223
17MP0001905_abnormal_dopamine_level2.12231262
18MP0003787_abnormal_imprinting2.12145945
19MP0008877_abnormal_DNA_methylation2.11245432
20MP0009745_abnormal_behavioral_response2.03418670
21MP0003137_abnormal_impulse_conducting2.01667910
22MP0004145_abnormal_muscle_electrophysio2.01250064
23MP0001968_abnormal_touch/_nociception2.00472545
24MP0006035_abnormal_mitochondrial_morpho1.99189246
25MP0002972_abnormal_cardiac_muscle1.90665269
26MP0001440_abnormal_grooming_behavior1.90150671
27MP0004147_increased_porphyrin_level1.88295422
28MP0003635_abnormal_synaptic_transmissio1.88224692
29MP0002102_abnormal_ear_morphology1.84679573
30MP0004859_abnormal_synaptic_plasticity1.78579613
31MP0002272_abnormal_nervous_system1.77026731
32MP0005620_abnormal_muscle_contractility1.74972823
33MP0002064_seizures1.70886079
34MP0005253_abnormal_eye_physiology1.62293406
35MP0004085_abnormal_heartbeat1.61405130
36MP0002572_abnormal_emotion/affect_behav1.59608398
37MP0001501_abnormal_sleep_pattern1.58620487
38MP0009046_muscle_twitch1.56908957
39MP0004924_abnormal_behavior1.56858544
40MP0005386_behavior/neurological_phenoty1.56858544
41MP0002063_abnormal_learning/memory/cond1.56697083
42MP0004270_analgesia1.49501220
43MP0002106_abnormal_muscle_physiology1.49038944
44MP0002735_abnormal_chemical_nociception1.48108631
45MP0008775_abnormal_heart_ventricle1.46471697
46MP0004043_abnormal_pH_regulation1.45918377
47MP0005187_abnormal_penis_morphology1.43559467
48MP0004142_abnormal_muscle_tone1.42349841
49MP0002332_abnormal_exercise_endurance1.40263173
50MP0002734_abnormal_mechanical_nocicepti1.38867437
51MP0006138_congestive_heart_failure1.33595430
52MP0005385_cardiovascular_system_phenoty1.32955283
53MP0001544_abnormal_cardiovascular_syste1.32955283
54MP0002067_abnormal_sensory_capabilities1.30931247
55MP0004087_abnormal_muscle_fiber1.29319605
56MP0001486_abnormal_startle_reflex1.29196466
57MP0009780_abnormal_chondrocyte_physiolo1.29136013
58MP0003011_delayed_dark_adaptation1.28486873
59MP0001984_abnormal_olfaction1.27678879
60MP0005084_abnormal_gallbladder_morpholo1.27174239
61MP0000750_abnormal_muscle_regeneration1.24947340
62MP0005369_muscle_phenotype1.23702941
63MP0002638_abnormal_pupillary_reflex1.20207723
64MP0004130_abnormal_muscle_cell1.17574649
65MP0001970_abnormal_pain_threshold1.15308339
66MP0003121_genomic_imprinting1.12385721
67MP0000747_muscle_weakness1.12240903
68MP0005423_abnormal_somatic_nervous1.12075183
69MP0000631_abnormal_neuroendocrine_gland1.09905492
70MP0003718_maternal_effect1.09367438
71MP0002163_abnormal_gland_morphology1.08025596
72MP0008058_abnormal_DNA_repair1.06571590
73MP0008569_lethality_at_weaning1.05802639
74MP0005535_abnormal_body_temperature1.05491751
75MP0000759_abnormal_skeletal_muscle1.05187956
76MP0010386_abnormal_urinary_bladder1.05128194
77MP0002876_abnormal_thyroid_physiology1.04983115
78MP0001188_hyperpigmentation1.04391225
79MP0002229_neurodegeneration1.03374664
80MP0005332_abnormal_amino_acid1.01271582
81MP0004885_abnormal_endolymph1.00317063
82MP0002090_abnormal_vision0.99489373
83MP0002269_muscular_atrophy0.98746958
84MP0002733_abnormal_thermal_nociception0.98375639
85MP0002234_abnormal_pharynx_morphology0.96949024
86MP0000230_abnormal_systemic_arterial0.96424672
87MP0002909_abnormal_adrenal_gland0.96310354
88MP0004811_abnormal_neuron_physiology0.96273019
89MP0002127_abnormal_cardiovascular_syste0.95939155
90MP0003136_yellow_coat_color0.94549504
91MP0005409_darkened_coat_color0.93342074
92MP0009697_abnormal_copulation0.92966333
93MP0003221_abnormal_cardiomyocyte_apopto0.90950086
94MP0002184_abnormal_innervation0.89494939
95MP0002882_abnormal_neuron_morphology0.89353854
96MP0001764_abnormal_homeostasis0.89310906
97MP0008872_abnormal_physiological_respon0.88528369
98MP0003806_abnormal_nucleotide_metabolis0.88502904
99MP0005266_abnormal_metabolism0.88181846
100MP0002160_abnormal_reproductive_system0.86957589
101MP0002139_abnormal_hepatobiliary_system0.86891356
102MP0002557_abnormal_social/conspecific_i0.86265407
103MP0000013_abnormal_adipose_tissue0.83838357
104MP0005171_absent_coat_pigmentation0.83112992
105MP0001485_abnormal_pinna_reflex0.82942863
106MP0001986_abnormal_taste_sensitivity0.82615413
107MP0005389_reproductive_system_phenotype0.82408745
108MP0003633_abnormal_nervous_system0.82291242
109MP0002066_abnormal_motor_capabilities/c0.81271250
110MP0000569_abnormal_digit_pigmentation0.81202140
111MP0005551_abnormal_eye_electrophysiolog0.79895924
112MP0006072_abnormal_retinal_apoptosis0.79648391
113MP0003183_abnormal_peptide_metabolism0.79129915
114MP0002069_abnormal_eating/drinking_beha0.78711913
115MP0008995_early_reproductive_senescence0.77614502
116MP0005379_endocrine/exocrine_gland_phen0.77072010
117MP0004510_myositis0.76950427
118MP0000955_abnormal_spinal_cord0.76307452
119MP0000778_abnormal_nervous_system0.76265725
120MP0003122_maternal_imprinting0.75933424
121MP0003950_abnormal_plasma_membrane0.74614829
122MP0005165_increased_susceptibility_to0.74571273
123MP0008789_abnormal_olfactory_epithelium0.74533026
124MP0003195_calcinosis0.74357144
125MP0003828_pulmonary_edema0.74301224
126MP0001664_abnormal_digestion0.74062267
127MP0005646_abnormal_pituitary_gland0.73355423
128MP0008875_abnormal_xenobiotic_pharmacok0.72685467
129MP0001727_abnormal_embryo_implantation0.72560342
130MP0005645_abnormal_hypothalamus_physiol0.71977100
131MP0010630_abnormal_cardiac_muscle0.70642828
132MP0004233_abnormal_muscle_weight0.70382387
133MP0000372_irregular_coat_pigmentation0.69192643
134MP0003329_amyloid_beta_deposits0.68732157
135MP0003879_abnormal_hair_cell0.68510461

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.75590898
2Abnormal mitochondria in muscle tissue (HP:0008316)7.21065169
3Mitochondrial inheritance (HP:0001427)6.63816627
4Progressive macrocephaly (HP:0004481)6.57209451
5Acute encephalopathy (HP:0006846)6.47591445
6Increased CSF lactate (HP:0002490)5.77005511
7Hepatocellular necrosis (HP:0001404)5.70705516
8Hepatic necrosis (HP:0002605)5.28802586
9Cerebral edema (HP:0002181)4.84321681
10Increased hepatocellular lipid droplets (HP:0006565)4.81865498
11Lipid accumulation in hepatocytes (HP:0006561)4.53474447
12Increased intramyocellular lipid droplets (HP:0012240)4.27009725
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.25602810
14Exercise intolerance (HP:0003546)4.20753646
15Respiratory failure (HP:0002878)4.17441702
16Lactic acidosis (HP:0003128)4.12955591
17Sudden death (HP:0001699)4.00103401
18Optic disc pallor (HP:0000543)3.91724364
19Increased muscle lipid content (HP:0009058)3.90414169
20Renal Fanconi syndrome (HP:0001994)3.89399225
21Abnormality of glycolysis (HP:0004366)3.80985037
22Increased serum pyruvate (HP:0003542)3.80985037
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.73810696
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.73810696
25Calf muscle hypertrophy (HP:0008981)3.70915926
26Muscle hypertrophy of the lower extremities (HP:0008968)3.70306367
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.65845287
28Leukodystrophy (HP:0002415)3.51355104
29Increased serum lactate (HP:0002151)3.48357952
303-Methylglutaconic aciduria (HP:0003535)3.27048866
31Pheochromocytoma (HP:0002666)3.08740606
32Palpitations (HP:0001962)3.03575497
33Neuroendocrine neoplasm (HP:0100634)3.02814210
34Febrile seizures (HP:0002373)2.99188947
35Exercise-induced myalgia (HP:0003738)2.96635271
36Exertional dyspnea (HP:0002875)2.93838484
37Medial flaring of the eyebrow (HP:0010747)2.92274778
38Ventricular tachycardia (HP:0004756)2.90311367
39Respiratory difficulties (HP:0002880)2.86767800
40Abnormality of the calf musculature (HP:0001430)2.83448733
41X-linked dominant inheritance (HP:0001423)2.78559969
42Focal motor seizures (HP:0011153)2.76362298
43Atrial fibrillation (HP:0005110)2.74402989
44Gait imbalance (HP:0002141)2.71953008
45Pancreatic cysts (HP:0001737)2.68867821
46Exercise-induced muscle cramps (HP:0003710)2.68586039
47Renal cortical cysts (HP:0000803)2.64953487
48Primary atrial arrhythmia (HP:0001692)2.64662275
49Supraventricular tachycardia (HP:0004755)2.63141260
50Abnormality of the labia minora (HP:0012880)2.58042802
51Syncope (HP:0001279)2.56484477
52Lethargy (HP:0001254)2.55359398
53Congenital primary aphakia (HP:0007707)2.55143859
54Abnormality of renal resorption (HP:0011038)2.54723313
55Supraventricular arrhythmia (HP:0005115)2.53897902
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53077327
57Abnormality of alanine metabolism (HP:0010916)2.53077327
58Hyperalaninemia (HP:0003348)2.53077327
59CNS demyelination (HP:0007305)2.52914297
60Pancreatic fibrosis (HP:0100732)2.52345460
61True hermaphroditism (HP:0010459)2.52250285
62Emotional lability (HP:0000712)2.41593269
63Muscle fiber splitting (HP:0003555)2.40688567
64Nephrogenic diabetes insipidus (HP:0009806)2.39186155
65Focal seizures (HP:0007359)2.38445025
66Myoglobinuria (HP:0002913)2.37272536
67Lipoatrophy (HP:0100578)2.36540484
68Glycosuria (HP:0003076)2.35736334
69Abnormality of urine glucose concentration (HP:0011016)2.35736334
70Dialeptic seizures (HP:0011146)2.34122564
71Poor suck (HP:0002033)2.33256220
72Dicarboxylic aciduria (HP:0003215)2.31998823
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31998823
74Nephronophthisis (HP:0000090)2.29775655
75Hyperventilation (HP:0002883)2.25613761
76Polyphagia (HP:0002591)2.23793938
77Prolonged QT interval (HP:0001657)2.22096373
78Abnormality of the renal cortex (HP:0011035)2.21445185
79Conjunctival hamartoma (HP:0100780)2.21380582
80Myokymia (HP:0002411)2.20589904
81Abnormality of midbrain morphology (HP:0002418)2.20367160
82Molar tooth sign on MRI (HP:0002419)2.20367160
83Epileptic encephalopathy (HP:0200134)2.20065138
84Ragged-red muscle fibers (HP:0003200)2.16273695
85Myotonia (HP:0002486)2.12960074
86Generalized tonic-clonic seizures (HP:0002069)2.11414644
87Hypoglycemic coma (HP:0001325)2.10432877
88Methylmalonic aciduria (HP:0012120)2.08705899
89Genital tract atresia (HP:0001827)2.08544329
90Hyperphosphaturia (HP:0003109)2.07831965
91Dilated cardiomyopathy (HP:0001644)2.04766183
92Hyperglycinuria (HP:0003108)2.04332646
93Hyperglycinemia (HP:0002154)2.04108491
94Vomiting (HP:0002013)2.02651236
95Rhabdomyolysis (HP:0003201)1.99656696
96Testicular atrophy (HP:0000029)1.97401468
97Left ventricular hypertrophy (HP:0001712)1.97379775
98Vaginal atresia (HP:0000148)1.96604431
99Abnormality of vitamin B metabolism (HP:0004340)1.96128741
100Gaze-evoked nystagmus (HP:0000640)1.95994870
101Congenital malformation of the right heart (HP:0011723)1.94897812
102Double outlet right ventricle (HP:0001719)1.94897812
103EMG: myopathic abnormalities (HP:0003458)1.94122371
104Methylmalonic acidemia (HP:0002912)1.94054537
105Abolished electroretinogram (ERG) (HP:0000550)1.93039960
106Congenital stationary night blindness (HP:0007642)1.91082959
107Abnormality of serine family amino acid metabolism (HP:0010894)1.89683251
108Abnormality of glycine metabolism (HP:0010895)1.89683251
109Broad-based gait (HP:0002136)1.89021529
110Progressive external ophthalmoplegia (HP:0000590)1.87211036
111Progressive cerebellar ataxia (HP:0002073)1.86757673
112Abnormality of serum amino acid levels (HP:0003112)1.85942134
113Hemiparesis (HP:0001269)1.85425711
114Epileptiform EEG discharges (HP:0011182)1.84413584
115Gliosis (HP:0002171)1.84186782
116Ketoacidosis (HP:0001993)1.83621641
117Congenital sensorineural hearing impairment (HP:0008527)1.82971873
118Hypsarrhythmia (HP:0002521)1.82193055
119Muscular hypotonia of the trunk (HP:0008936)1.82030807
120EEG with generalized epileptiform discharges (HP:0011198)1.81673273
121Atonic seizures (HP:0010819)1.81464689
122Muscle stiffness (HP:0003552)1.81150219
123Anxiety (HP:0000739)1.81124164
124Abnormal EKG (HP:0003115)1.81026268
125Bundle branch block (HP:0011710)1.80588061
126Ventricular fibrillation (HP:0001663)1.80562581
127Cerebral hemorrhage (HP:0001342)1.78166007
128Action tremor (HP:0002345)1.77123333
129Abnormal eating behavior (HP:0100738)1.75813940
130Male pseudohermaphroditism (HP:0000037)1.75446263
131Abnormality of the renal medulla (HP:0100957)1.75030276
132Abnormal urine phosphate concentration (HP:0012599)1.74319665
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.73628085
134Hypothermia (HP:0002045)1.73352527
135Ventricular arrhythmia (HP:0004308)1.71695030
136Absence seizures (HP:0002121)1.71193812
137Generalized aminoaciduria (HP:0002909)1.71112729
138Aplasia/hypoplasia of the uterus (HP:0008684)1.70551271
139Neoplasm of head and neck (HP:0012288)1.70534923
140Esophageal neoplasm (HP:0100751)1.70534923
141Microvesicular hepatic steatosis (HP:0001414)1.70475073
142Hypomagnesemia (HP:0002917)1.70444743
143Hypoplastic left heart (HP:0004383)1.68088405
144Visual hallucinations (HP:0002367)1.67282005
145Abnormality of cells of the erythroid lineage (HP:0012130)1.67008334
146Neoplasm of the adrenal gland (HP:0100631)1.66924693
147Limb dystonia (HP:0002451)1.65887880
148Blindness (HP:0000618)1.65533112
149Rimmed vacuoles (HP:0003805)1.63876416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.24929461
2NME14.04824934
3MAP3K123.56647502
4MYLK3.36998192
5MAP4K22.83932901
6CASK2.68379574
7TRIM282.57708875
8OBSCN2.54409564
9EPHA42.48659669
10STK162.45564988
11GRK72.39425880
12MUSK2.26742939
13PDK32.20508743
14PDK42.20508743
15ARAF2.16906360
16ERBB32.16896078
17LMTK22.11367693
18NME22.09310179
19MAP2K72.02724094
20PHKG11.98295230
21PHKG21.98295230
22NTRK31.83756958
23STK391.81097508
24GRK51.75998149
25MAP3K41.75785286
26RIPK41.74278138
27WNK41.71435716
28PNCK1.64605074
29CAMK2D1.54269485
30BCKDK1.53451289
31BMPR21.50531542
32PIK3CA1.47091636
33OXSR11.44041943
34PLK21.42127129
35PDK21.39656873
36TTN1.39235802
37MST1R1.38933910
38CSNK1G21.38068935
39PINK11.37852851
40CAMK2A1.37080179
41CAMK2B1.28877442
42MAP2K41.28639435
43CSNK1G31.27262316
44GRK11.20170819
45PTK2B1.18140774
46PLK31.15957906
47DAPK21.15868866
48CSNK1G11.14822718
49MKNK21.13661815
50CAMKK21.10834650
51MARK11.08118887
52MINK11.06032054
53CDK191.03193474
54CSNK1A1L1.00803552
55CAMK2G0.95925286
56TNIK0.95668663
57DYRK20.92669686
58BRAF0.90453896
59FER0.89335635
60SRPK10.89056729
61MST40.88370817
62PLK40.85326322
63DAPK30.81091080
64NUAK10.81052791
65PRKCE0.80585638
66TSSK60.80554895
67ADRBK10.80418427
68ADRBK20.80112752
69ILK0.78172215
70BCR0.78097599
71MAPKAPK50.76840794
72MKNK10.76736193
73PBK0.76565810
74MAPKAPK30.74576047
75FGR0.73385334
76MAPK130.73079863
77PAK30.72968711
78PRKCG0.71304802
79PRKACA0.70543501
80VRK10.68809083
81ABL20.68776632
82STK240.68519233
83INSRR0.68354202
84ROCK20.68277476
85UHMK10.64044220
86DAPK10.63567237
87PAK60.62373020
88EPHA30.59482189
89GRK60.59275861
90ZAK0.58432202
91CAMK10.57653573
92PKN10.57331353
93TTK0.57019489
94TLK10.56296288
95MAPK120.55878895
96TIE10.55421916
97TXK0.54780656
98STK38L0.53631151
99TAOK30.52793108
100FGFR20.51469737
101LIMK10.50065144
102ACVR1B0.49481940
103CDK50.49381467
104BUB10.49308205
105BMPR1B0.48779822
106CSNK1A10.46214304
107PLK10.45115816
108BRSK20.44696960
109RPS6KA40.43987283
110WNK30.43836682
111NEK10.43180486
112ROCK10.42230988
113MAP2K60.37988653
114WEE10.37917883
115MAP3K110.37439159
116RPS6KA50.36963637
117CSNK1E0.36365039
118EIF2AK20.35870062
119FES0.35666355
120PRKACB0.35377704
121RAF10.34972211
122STK30.34861007
123NTRK20.34800699
124CDK30.34361687
125PRKG10.33623407
126PRKCA0.32484130
127AKT30.31803872
128WNK10.31427462
129EIF2AK10.29571472
130CCNB10.29298393
131DYRK1A0.28685359
132PRKACG0.28062313
133MAP2K10.27859138
134MAP3K90.27444632
135EIF2AK30.26874116
136PRKCQ0.26783862
137CSNK2A10.26257902
138CDK140.25863347

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.61706458
2Parkinsons disease_Homo sapiens_hsa050125.75540925
3Alzheimers disease_Homo sapiens_hsa050104.50516877
4Huntingtons disease_Homo sapiens_hsa050164.01313717
5Cardiac muscle contraction_Homo sapiens_hsa042603.76505936
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.58635978
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.35554733
8Ribosome_Homo sapiens_hsa030102.22343190
9Proteasome_Homo sapiens_hsa030502.13502906
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93847851
11Propanoate metabolism_Homo sapiens_hsa006401.89999084
12Collecting duct acid secretion_Homo sapiens_hsa049661.86836427
13Nicotine addiction_Homo sapiens_hsa050331.75964811
14Sulfur metabolism_Homo sapiens_hsa009201.68679797
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65041806
16Pyruvate metabolism_Homo sapiens_hsa006201.61124663
17Fatty acid elongation_Homo sapiens_hsa000621.41647929
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41167232
19Nitrogen metabolism_Homo sapiens_hsa009101.39531944
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.36114961
21Carbon metabolism_Homo sapiens_hsa012001.28206096
22Protein export_Homo sapiens_hsa030601.25573872
23Basal transcription factors_Homo sapiens_hsa030221.23244696
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18810934
25Butanoate metabolism_Homo sapiens_hsa006501.18009528
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14526935
27RNA polymerase_Homo sapiens_hsa030201.13600290
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13575457
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09633398
30Circadian rhythm_Homo sapiens_hsa047101.06533883
31Selenocompound metabolism_Homo sapiens_hsa004501.05906554
32Taste transduction_Homo sapiens_hsa047421.04642394
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03880152
34Synaptic vesicle cycle_Homo sapiens_hsa047211.02951362
35Vibrio cholerae infection_Homo sapiens_hsa051101.01563286
36Dilated cardiomyopathy_Homo sapiens_hsa054140.98384169
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97435189
38Vitamin B6 metabolism_Homo sapiens_hsa007500.96937704
39Steroid biosynthesis_Homo sapiens_hsa001000.93599320
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92917250
41RNA degradation_Homo sapiens_hsa030180.87602768
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86711830
43Calcium signaling pathway_Homo sapiens_hsa040200.84963401
44Serotonergic synapse_Homo sapiens_hsa047260.84236637
45Amphetamine addiction_Homo sapiens_hsa050310.84163810
46Fatty acid degradation_Homo sapiens_hsa000710.83536524
47Circadian entrainment_Homo sapiens_hsa047130.81406100
48GABAergic synapse_Homo sapiens_hsa047270.81276518
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.80421839
50Homologous recombination_Homo sapiens_hsa034400.80061158
51* Metabolic pathways_Homo sapiens_hsa011000.79727343
52Caffeine metabolism_Homo sapiens_hsa002320.77300341
53Oocyte meiosis_Homo sapiens_hsa041140.76413300
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76054079
55Long-term potentiation_Homo sapiens_hsa047200.75629401
56Morphine addiction_Homo sapiens_hsa050320.75589184
57Phenylalanine metabolism_Homo sapiens_hsa003600.74064888
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71030982
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70003981
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69687994
61Salivary secretion_Homo sapiens_hsa049700.69174710
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68114627
63Renin secretion_Homo sapiens_hsa049240.68097411
64Mismatch repair_Homo sapiens_hsa034300.68094822
65Glutamatergic synapse_Homo sapiens_hsa047240.67523941
66Tyrosine metabolism_Homo sapiens_hsa003500.67195795
67Olfactory transduction_Homo sapiens_hsa047400.66998297
68Fatty acid metabolism_Homo sapiens_hsa012120.66923994
69Phototransduction_Homo sapiens_hsa047440.66505448
70Dopaminergic synapse_Homo sapiens_hsa047280.64738382
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62742835
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62525843
73Fanconi anemia pathway_Homo sapiens_hsa034600.62005469
74Folate biosynthesis_Homo sapiens_hsa007900.61831282
75Non-homologous end-joining_Homo sapiens_hsa034500.61051824
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.60091529
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57869083
78Arginine biosynthesis_Homo sapiens_hsa002200.56932455
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56223289
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55661903
81Peroxisome_Homo sapiens_hsa041460.53576690
82Gastric acid secretion_Homo sapiens_hsa049710.52597449
83Retinol metabolism_Homo sapiens_hsa008300.51967913
84Histidine metabolism_Homo sapiens_hsa003400.51373357
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49865983
86Oxytocin signaling pathway_Homo sapiens_hsa049210.47703158
87Nucleotide excision repair_Homo sapiens_hsa034200.45602919
88Insulin secretion_Homo sapiens_hsa049110.44519900
89Pyrimidine metabolism_Homo sapiens_hsa002400.43726192
90Long-term depression_Homo sapiens_hsa047300.43556953
91Rheumatoid arthritis_Homo sapiens_hsa053230.43212517
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42037408
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41749235
94Purine metabolism_Homo sapiens_hsa002300.40561487
95Fructose and mannose metabolism_Homo sapiens_hsa000510.39742950
96Cholinergic synapse_Homo sapiens_hsa047250.39600187
97Arginine and proline metabolism_Homo sapiens_hsa003300.38868454
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.38294194
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38254425
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.37971474
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35916840
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35312778
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35062629
104Glutathione metabolism_Homo sapiens_hsa004800.35059589
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34010676
106Cocaine addiction_Homo sapiens_hsa050300.33749315
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33448948
108Glucagon signaling pathway_Homo sapiens_hsa049220.32970838
109Linoleic acid metabolism_Homo sapiens_hsa005910.32725688
110Arachidonic acid metabolism_Homo sapiens_hsa005900.30940320
111Sulfur relay system_Homo sapiens_hsa041220.28376452
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28186342
113Biosynthesis of amino acids_Homo sapiens_hsa012300.27884998
114beta-Alanine metabolism_Homo sapiens_hsa004100.26676300
115Pancreatic secretion_Homo sapiens_hsa049720.25606568
116Chemical carcinogenesis_Homo sapiens_hsa052040.24551219
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23969355
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23844370
119Starch and sucrose metabolism_Homo sapiens_hsa005000.22050881
120Tryptophan metabolism_Homo sapiens_hsa003800.20876625
121Ether lipid metabolism_Homo sapiens_hsa005650.20828890
122Galactose metabolism_Homo sapiens_hsa000520.18297789
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17602760
124Gap junction_Homo sapiens_hsa045400.17358931
125Regulation of autophagy_Homo sapiens_hsa041400.15696189
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14405828
127African trypanosomiasis_Homo sapiens_hsa051430.14231515
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13822869
129cAMP signaling pathway_Homo sapiens_hsa040240.13219471

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