ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	9.08506830
2	ADP metabolic process (GO:0046031)	7.50633171
3	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	6.55264823
4	regulation of activation of Janus kinase activity (GO:0010533)	6.51875264
5	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	5.91116684
6	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	5.03368425
7	positive regulation of cell fate commitment (GO:0010455)	4.86158950
8	hair cycle (GO:0042633)	4.82005649
9	molting cycle (GO:0042303)	4.82005649
10	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	4.60210404
11	positive regulation of T-helper 1 type immune response (GO:0002827)	4.56831620
12	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.56575797
13	negative regulation of interleukin-10 production (GO:0032693)	4.54330721
14	purine ribonucleoside diphosphate metabolic process (GO:0009179)	4.46607615
15	purine nucleoside diphosphate metabolic process (GO:0009135)	4.46607615
16	positive regulation of interleukin-17 production (GO:0032740)	4.43919768
17	AMP metabolic process (GO:0046033)	4.41962117
18	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	4.36380658
19	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.22793625
20	glycerophospholipid catabolic process (GO:0046475)	3.97586588
21	cellular response to zinc ion (GO:0071294)	3.84857735
22	positive regulation of defense response to virus by host (GO:0002230)	3.83226268
23	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.80040868
24	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.75757829
25	purine deoxyribonucleotide metabolic process (GO:0009151)	3.75045343
26	respiratory chain complex IV assembly (GO:0008535)	3.71771102
27	negative regulation of mast cell activation (GO:0033004)	3.67309862
28	prenylation (GO:0097354)	3.66511547
29	protein prenylation (GO:0018342)	3.66511547
30	trivalent inorganic anion homeostasis (GO:0072506)	3.63376785
31	phosphate ion homeostasis (GO:0055062)	3.63376785
32	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.57617762
33	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.57611975
34	cellular response to nicotine (GO:0071316)	3.53676073
35	protein complex biogenesis (GO:0070271)	3.52747429
36	cytochrome complex assembly (GO:0017004)	3.51013034
37	platelet dense granule organization (GO:0060155)	3.43570915
38	ribonucleoside diphosphate metabolic process (GO:0009185)	3.42215721
39	pantothenate metabolic process (GO:0015939)	3.41927754
40	regulation of vitamin D biosynthetic process (GO:0060556)	3.32573452
41	fucose catabolic process (GO:0019317)	3.25334790
42	L-fucose metabolic process (GO:0042354)	3.25334790
43	L-fucose catabolic process (GO:0042355)	3.25334790
44	lipid particle organization (GO:0034389)	3.24660936
45	prostate gland growth (GO:0060736)	3.19800025
46	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.17631618
47	protein K6-linked ubiquitination (GO:0085020)	3.16274557
48	anterograde synaptic vesicle transport (GO:0048490)	3.14476371
49	DNA deamination (GO:0045006)	3.14312483
50	regulation of T-helper 1 type immune response (GO:0002825)	3.13921635
51	multicellular organism reproduction (GO:0032504)	3.12909662
52	negative regulation of protein autophosphorylation (GO:0031953)	3.05400278
53	positive regulation of T-helper cell differentiation (GO:0045624)	3.04174091
54	mitochondrial respiratory chain complex assembly (GO:0033108)	3.03767449
55	reciprocal meiotic recombination (GO:0007131)	3.02029852
56	reciprocal DNA recombination (GO:0035825)	3.02029852
57	regulation of B cell apoptotic process (GO:0002902)	2.94258096
58	regulation of cilium movement (GO:0003352)	2.93381415
59	negative regulation of membrane potential (GO:0045837)	2.93123884
60	protein polyglutamylation (GO:0018095)	2.90122174
61	magnesium ion transport (GO:0015693)	2.89731492
62	cullin deneddylation (GO:0010388)	2.83155556
63	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.83051315
64	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.82849677
65	plasma membrane fusion (GO:0045026)	2.82593083
66	DNA double-strand break processing (GO:0000729)	2.82403366
67	proline transport (GO:0015824)	2.81171187
68	protein peptidyl-prolyl isomerization (GO:0000413)	2.80746865
69	cellular anion homeostasis (GO:0030002)	2.76879429
70	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.76688272
71	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.76688272
72	branched-chain amino acid catabolic process (GO:0009083)	2.75705882
73	replication fork processing (GO:0031297)	2.71904697
74	heart contraction (GO:0060047)	2.71115681
75	heart process (GO:0003015)	2.71115681
76	regulation of helicase activity (GO:0051095)	2.67943119
77	single strand break repair (GO:0000012)	2.67495803
78	male meiosis (GO:0007140)	2.66856433
79	cell wall macromolecule catabolic process (GO:0016998)	2.63385328
80	preassembly of GPI anchor in ER membrane (GO:0016254)	2.62108705
81	valine metabolic process (GO:0006573)	2.61656276
82	limb bud formation (GO:0060174)	2.59899802
83	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.59757635
84	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.58982241
85	cellular response to cadmium ion (GO:0071276)	2.57132185
86	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.56626414
87	NADH dehydrogenase complex assembly (GO:0010257)	2.56626414
88	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.56626414
89	mannosylation (GO:0097502)	2.55211109
90	nucleoside diphosphate phosphorylation (GO:0006165)	2.55067682
91	neuronal action potential propagation (GO:0019227)	2.54198980
92	regulation of T-helper cell differentiation (GO:0045622)	2.53216541
93	negative regulation of neurological system process (GO:0031645)	2.53014983
94	dendritic spine morphogenesis (GO:0060997)	2.53007828
95	peptidyl-proline modification (GO:0018208)	2.50985399
96	regulation of translational termination (GO:0006449)	2.48159078
97	dopamine transport (GO:0015872)	2.46460346
98	regulation of interleukin-17 production (GO:0032660)	2.44824838
99	protein targeting to vacuole (GO:0006623)	2.43577213
100	establishment of protein localization to vacuole (GO:0072666)	2.43577213

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA1_22025678_ChIP-Seq_K562_Human	2.98818717
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.89562189
3	VDR_22108803_ChIP-Seq_LS180_Human	2.83181765
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.64809249
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.64007867
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.62021945
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.56370556
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.47425534
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.33536595
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.30060819
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18001798
12	FUS_26573619_Chip-Seq_HEK293_Human	2.15573626
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.04726723
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.02065712
15	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.91794367
16	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.91794367
17	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.85655686
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.81452896
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80855161
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78252048
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.78188067
22	P300_19829295_ChIP-Seq_ESCs_Human	1.75709858
23	EWS_26573619_Chip-Seq_HEK293_Human	1.73887129
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.73130022
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.70125482
26	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.70014822
27	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.69415431
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.68760379
29	NANOG_19829295_ChIP-Seq_ESCs_Human	1.68506449
30	SOX2_19829295_ChIP-Seq_ESCs_Human	1.68506449
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65438559
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64874085
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.63542275
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.61258163
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57993409
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.56633080
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51178819
38	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.49852413
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.49335826
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46939704
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46789144
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46443895
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45845931
44	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.45285867
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43136760
46	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.42386039
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42312061
48	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.40513947
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38854435
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.38854435
51	DCP1A_22483619_ChIP-Seq_HELA_Human	1.35140102
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.32655118
53	CDX2_22108803_ChIP-Seq_LS180_Human	1.32114539
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.30814623
55	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.30501795
56	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30433141
57	AR_20517297_ChIP-Seq_VCAP_Human	1.28950971
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27633478
59	GATA3_26560356_Chip-Seq_TH2_Human	1.26691196
60	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25610307
61	HOXB7_26014856_ChIP-Seq_BT474_Human	1.25063951
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24771727
63	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23516414
64	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23347191
65	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.22246697
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22005752
67	SCL_19346495_ChIP-Seq_HPC-7_Human	1.21692394
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21072462
69	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21043106
70	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20867876
71	NCOR_22424771_ChIP-Seq_293T_Human	1.17511049
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17095983
73	JUN_21703547_ChIP-Seq_K562_Human	1.17052097
74	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.15295561
75	TAF15_26573619_Chip-Seq_HEK293_Human	1.15222998
76	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.15164410
77	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14451379
78	HTT_18923047_ChIP-ChIP_STHdh_Human	1.13596030
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.13550078
80	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13366404
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.13256590
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.13113778
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11964108
84	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.11535771
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09972838
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09542821
87	STAT3_23295773_ChIP-Seq_U87_Human	1.08404445
88	MYC_19829295_ChIP-Seq_ESCs_Human	1.08179170
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.07076239
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03875376
91	AR_25329375_ChIP-Seq_VCAP_Human	1.03811556
92	TCF4_23295773_ChIP-Seq_U87_Human	1.03117465
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02044132
94	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.00867930
95	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.00368097
96	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.99909670
97	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99351593
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99244337
99	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.98293188
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98152083

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.48375352
2	MP0003011_delayed_dark_adaptation	3.91589348
3	MP0002102_abnormal_ear_morphology	3.81374621
4	MP0003950_abnormal_plasma_membrane	3.68546035
5	MP0002837_dystrophic_cardiac_calcinosis	3.63523676
6	MP0005075_abnormal_melanosome_morpholog	3.08953522
7	MP0005645_abnormal_hypothalamus_physiol	2.67225894
8	MP0002139_abnormal_hepatobiliary_system	2.59851943
9	MP0000372_irregular_coat_pigmentation	2.42935465
10	MP0006054_spinal_hemorrhage	2.40290196
11	MP0003880_abnormal_central_pattern	2.37247977
12	MP0004147_increased_porphyrin_level	2.20039352
13	MP0005367_renal/urinary_system_phenotyp	2.17111989
14	MP0000516_abnormal_urinary_system	2.17111989
15	MP0001879_abnormal_lymphatic_vessel	2.11104740
16	MP0005551_abnormal_eye_electrophysiolog	2.09531810
17	MP0003283_abnormal_digestive_organ	1.90531076
18	MP0001188_hyperpigmentation	1.89462919
19	MP0002254_reproductive_system_inflammat	1.85324729
20	MP0002638_abnormal_pupillary_reflex	1.79599393
21	MP0005410_abnormal_fertilization	1.72492180
22	MP0005379_endocrine/exocrine_gland_phen	1.67403809
23	MP0006072_abnormal_retinal_apoptosis	1.67374651
24	MP0009046_muscle_twitch	1.64528037
25	MP0001984_abnormal_olfaction	1.63509537
26	MP0001968_abnormal_touch/_nociception	1.62067993
27	MP0003136_yellow_coat_color	1.60197761
28	MP0009697_abnormal_copulation	1.58335943
29	MP0001986_abnormal_taste_sensitivity	1.57286939
30	MP0002295_abnormal_pulmonary_circulatio	1.52357280
31	MP0002282_abnormal_trachea_morphology	1.50760429
32	MP0004215_abnormal_myocardial_fiber	1.50207984
33	MP0008260_abnormal_autophagy	1.50008655
34	MP0003718_maternal_effect	1.48439975
35	MP0002938_white_spotting	1.48325259
36	MP0001502_abnormal_circadian_rhythm	1.48040514
37	MP0005167_abnormal_blood-brain_barrier	1.44756232
38	MP0008877_abnormal_DNA_methylation	1.41152522
39	MP0010368_abnormal_lymphatic_system	1.38241055
40	MP0000613_abnormal_salivary_gland	1.32818630
41	MP0008775_abnormal_heart_ventricle	1.32043493
42	MP0004885_abnormal_endolymph	1.29921194
43	MP0003186_abnormal_redox_activity	1.29323435
44	MP0008995_early_reproductive_senescence	1.28863267
45	MP0008872_abnormal_physiological_respon	1.28056613
46	MP0001764_abnormal_homeostasis	1.27623927
47	MP0003787_abnormal_imprinting	1.25649865
48	MP0005253_abnormal_eye_physiology	1.23656626
49	MP0010234_abnormal_vibrissa_follicle	1.21854813
50	MP0002736_abnormal_nociception_after	1.21500054
51	MP0000678_abnormal_parathyroid_gland	1.20790972
52	MP0005636_abnormal_mineral_homeostasis	1.15363849
53	MP0010678_abnormal_skin_adnexa	1.15286720
54	MP0004484_altered_response_of	1.14113606
55	MP0001501_abnormal_sleep_pattern	1.09959905
56	MP0002751_abnormal_autonomic_nervous	1.09180547
57	MP0000383_abnormal_hair_follicle	1.07499927
58	MP0005647_abnormal_sex_gland	1.04809423
59	MP0000639_abnormal_adrenal_gland	1.02409673
60	MP0009780_abnormal_chondrocyte_physiolo	1.01653295
61	MP0005248_abnormal_Harderian_gland	1.00069589
62	MP0010352_gastrointestinal_tract_polyps	0.98844403
63	MP0002272_abnormal_nervous_system	0.98237363
64	MP0008875_abnormal_xenobiotic_pharmacok	0.95915739
65	MP0005389_reproductive_system_phenotype	0.95109798
66	MP0001765_abnormal_ion_homeostasis	0.93423089
67	MP0000538_abnormal_urinary_bladder	0.91835851
68	MP0010329_abnormal_lipoprotein_level	0.89579513
69	MP0003638_abnormal_response/metabolism_	0.89063034
70	MP0005408_hypopigmentation	0.87837240
71	MP0008058_abnormal_DNA_repair	0.87632001
72	MP0009745_abnormal_behavioral_response	0.85459609
73	MP0001119_abnormal_female_reproductive	0.84818175
74	MP0002234_abnormal_pharynx_morphology	0.84028153
75	MP0004142_abnormal_muscle_tone	0.82638858
76	MP0004019_abnormal_vitamin_homeostasis	0.82613403
77	MP0004084_abnormal_cardiac_muscle	0.81998348
78	MP0000653_abnormal_sex_gland	0.80514174
79	MP0002653_abnormal_ependyma_morphology	0.77695970
80	MP0009053_abnormal_anal_canal	0.77647027
81	MP0002277_abnormal_respiratory_mucosa	0.77215404
82	MP0002160_abnormal_reproductive_system	0.75602336
83	MP0006036_abnormal_mitochondrial_physio	0.74257177
84	MP0005084_abnormal_gallbladder_morpholo	0.74139196
85	MP0005332_abnormal_amino_acid	0.74028268
86	MP0003303_peritoneal_inflammation	0.71393995
87	MP0002933_joint_inflammation	0.70986495
88	MP0005395_other_phenotype	0.70770912
89	MP0001929_abnormal_gametogenesis	0.69331114
90	MP0005386_behavior/neurological_phenoty	0.68953558
91	MP0004924_abnormal_behavior	0.68953558
92	MP0000462_abnormal_digestive_system	0.68575202
93	MP0001145_abnormal_male_reproductive	0.68130944
94	MP0002876_abnormal_thyroid_physiology	0.67949759
95	MP0000230_abnormal_systemic_arterial	0.64748803
96	MP0004782_abnormal_surfactant_physiolog	0.64606860
97	MP0002138_abnormal_hepatobiliary_system	0.63111543
98	MP0000631_abnormal_neuroendocrine_gland	0.61855364
99	MP0002733_abnormal_thermal_nociception	0.61486579
100	MP0005535_abnormal_body_temperature	0.60988200

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retrobulbar optic neuritis (HP:0100654)	5.41008687
2	Optic neuritis (HP:0100653)	5.41008687
3	Orchitis (HP:0100796)	4.44641390
4	Hypophosphatemic rickets (HP:0004912)	3.66843962
5	Type 2 muscle fiber atrophy (HP:0003554)	3.54898806
6	Popliteal pterygium (HP:0009756)	3.47979360
7	Myositis (HP:0100614)	3.38080436
8	Abnormality of placental membranes (HP:0011409)	3.29252627
9	Amniotic constriction ring (HP:0009775)	3.29252627
10	Keratoconjunctivitis sicca (HP:0001097)	3.27346710
11	Medial flaring of the eyebrow (HP:0010747)	3.26629624
12	Nephronophthisis (HP:0000090)	3.17813367
13	Hypoplasia of the pons (HP:0012110)	3.16021836
14	Keratoconjunctivitis (HP:0001096)	3.06134538
15	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.02350185
16	Abnormality of the pons (HP:0007361)	2.94166507
17	Cone-rod dystrophy (HP:0000548)	2.93843443
18	Cerebellar dysplasia (HP:0007033)	2.93717698
19	Type II lissencephaly (HP:0007260)	2.92779936
20	Decreased central vision (HP:0007663)	2.89440951
21	Muscle fiber atrophy (HP:0100295)	2.87372568
22	Delayed gross motor development (HP:0002194)	2.83956133
23	Hepatocellular necrosis (HP:0001404)	2.77208034
24	Generalized aminoaciduria (HP:0002909)	2.73489041
25	Pancreatic cysts (HP:0001737)	2.68806262
26	Intestinal atresia (HP:0011100)	2.67890252
27	Thyroid-stimulating hormone excess (HP:0002925)	2.63403151
28	Hepatic necrosis (HP:0002605)	2.59966448
29	Congenital primary aphakia (HP:0007707)	2.52857023
30	Keratoconus (HP:0000563)	2.50882475
31	Increased corneal curvature (HP:0100692)	2.50882475
32	Volvulus (HP:0002580)	2.48698664
33	Gait imbalance (HP:0002141)	2.43100743
34	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.39174875
35	Abnormality of the renal medulla (HP:0100957)	2.38171457
36	Pancreatic fibrosis (HP:0100732)	2.34388710
37	Nephrogenic diabetes insipidus (HP:0009806)	2.33629239
38	Genital tract atresia (HP:0001827)	2.30880646
39	Pendular nystagmus (HP:0012043)	2.28931630
40	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.27574674
41	Abnormality of midbrain morphology (HP:0002418)	2.23019054
42	Molar tooth sign on MRI (HP:0002419)	2.23019054
43	Thyroiditis (HP:0100646)	2.21230450
44	Hypothermia (HP:0002045)	2.18158449
45	Focal motor seizures (HP:0011153)	2.17597669
46	Vaginal atresia (HP:0000148)	2.14558278
47	Akinesia (HP:0002304)	2.14457406
48	Optic nerve hypoplasia (HP:0000609)	2.12116732
49	Neoplasm of the adrenal cortex (HP:0100641)	2.09062817
50	Progressive macrocephaly (HP:0004481)	2.07914518
51	Esophageal neoplasm (HP:0100751)	2.07265270
52	Neoplasm of head and neck (HP:0012288)	2.07265270
53	Congenital stationary night blindness (HP:0007642)	2.06043367
54	Methylmalonic acidemia (HP:0002912)	2.05968007
55	Distal arthrogryposis (HP:0005684)	2.05712742
56	True hermaphroditism (HP:0010459)	2.05170750
57	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.03388716
58	Abnormal mitochondria in muscle tissue (HP:0008316)	2.03264718
59	Hyperthyroidism (HP:0000836)	2.03106950
60	Increased CSF lactate (HP:0002490)	2.02229949
61	Adactyly (HP:0009776)	2.01278047
62	Renal Fanconi syndrome (HP:0001994)	1.98739433
63	Arterial thrombosis (HP:0004420)	1.97341675
64	Petechiae (HP:0000967)	1.94910343
65	Brittle hair (HP:0002299)	1.94484208
66	Areflexia of lower limbs (HP:0002522)	1.93827268
67	Tetany (HP:0001281)	1.92897569
68	Abnormality of the renal cortex (HP:0011035)	1.92686047
69	Renal cortical cysts (HP:0000803)	1.91140771
70	Increased serum lactate (HP:0002151)	1.90667475
71	Mitochondrial inheritance (HP:0001427)	1.88277052
72	Increased intramyocellular lipid droplets (HP:0012240)	1.86006336
73	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.84855345
74	Abnormal spermatogenesis (HP:0008669)	1.83776888
75	Fetal akinesia sequence (HP:0001989)	1.80994520
76	Hyporeflexia of lower limbs (HP:0002600)	1.79626220
77	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.79014708
78	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.79014708
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.78443410
80	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.78392634
81	Methylmalonic aciduria (HP:0012120)	1.77084869
82	Hyperglycinuria (HP:0003108)	1.74751047
83	Encephalitis (HP:0002383)	1.74638133
84	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.74154679
85	Acute necrotizing encephalopathy (HP:0006965)	1.73922294
86	Abnormal protein glycosylation (HP:0012346)	1.72468725
87	Abnormal glycosylation (HP:0012345)	1.72468725
88	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.72468725
89	Abnormal protein N-linked glycosylation (HP:0012347)	1.72468725
90	Severe visual impairment (HP:0001141)	1.71609881
91	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.71230640
92	Disproportionate short-trunk short stature (HP:0003521)	1.70886725
93	Abnormality of methionine metabolism (HP:0010901)	1.70737245
94	Visual hallucinations (HP:0002367)	1.70241002
95	Decreased muscle mass (HP:0003199)	1.70197678
96	Abnormality of the labia minora (HP:0012880)	1.69562036
97	Poor head control (HP:0002421)	1.68750757
98	Abnormal rod and cone electroretinograms (HP:0008323)	1.68359869
99	Gastrointestinal atresia (HP:0002589)	1.67241911
100	Unilateral renal agenesis (HP:0000122)	1.66618233

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	9.70615068
2	FRK	4.88505408
3	NUAK1	2.63785805
4	BCKDK	2.44242565
5	STK24	2.41375751
6	MKNK2	2.38401783
7	FGFR2	2.03357716
8	MKNK1	1.96360682
9	ZAK	1.93952964
10	GRK1	1.92921285
11	EPHA3	1.87208324
12	CASK	1.81061706
13	CSNK1G3	1.48668165
14	PLK2	1.48539788
15	WNK3	1.45446548
16	FER	1.38521735
17	WNK4	1.36015380
18	ARAF	1.34040748
19	CSNK1A1L	1.30562438
20	EIF2AK1	1.29894471
21	EPHA4	1.27621795
22	ADRBK2	1.26590439
23	CSNK1G2	1.25553476
24	PHKG1	1.20084982
25	PHKG2	1.20084982
26	CSNK1G1	1.17887944
27	STK3	1.17697540
28	BCR	1.14586992
29	PLK3	1.11424337
30	ACVR1B	1.06710039
31	PIM2	1.03972836
32	PAK3	1.00223629
33	PRKCE	0.95533557
34	BMPR1B	0.94649315
35	IKBKB	0.93231540
36	TLK1	0.86875118
37	TAOK1	0.85477128
38	PINK1	0.82119728
39	SIK3	0.81483154
40	VRK1	0.80872839
41	TNIK	0.79196678
42	NLK	0.78739230
43	INSRR	0.73295016
44	STK39	0.71854540
45	CHUK	0.71029235
46	LATS1	0.70328268
47	OBSCN	0.69443608
48	DYRK2	0.69333178
49	BUB1	0.69240847
50	RPS6KA5	0.67385420
51	RAF1	0.66395381
52	TIE1	0.63175418
53	MAPK13	0.62814748
54	EIF2AK3	0.57097943
55	PRKCQ	0.56141204
56	DAPK2	0.55304248
57	ERBB3	0.55142106
58	MARK3	0.51388984
59	CAMK2A	0.51144084
60	FGFR3	0.50560305
61	SRPK1	0.50546804
62	TRIM28	0.47724179
63	VRK2	0.47636585
64	PRKCI	0.47158134
65	PIK3CG	0.45805695
66	MAPK11	0.43971652
67	TTK	0.43668338
68	PRKCG	0.43538310
69	TRPM7	0.43323643
70	MAPKAPK5	0.43080098
71	AKT3	0.42944054
72	ATM	0.42211045
73	PRKG1	0.42118572
74	PLK1	0.42084805
75	CSNK1A1	0.40312983
76	STK16	0.40178625
77	MATK	0.40057802
78	STK38L	0.38214271
79	KIT	0.38062514
80	LATS2	0.37649353
81	OXSR1	0.37612705
82	LIMK1	0.37069317
83	BRAF	0.36929390
84	ADRBK1	0.35634761
85	CSNK1D	0.34151956
86	RPS6KB2	0.33758098
87	MAP3K13	0.33393182
88	IRAK1	0.31561416
89	MAP3K3	0.30006305
90	RPS6KA4	0.29471867
91	PRKCH	0.28917436
92	TSSK6	0.28769711
93	TEC	0.28734637
94	PLK4	0.28187106
95	MINK1	0.28154100
96	EPHB1	0.27995444
97	CAMK2D	0.26820849
98	DYRK3	0.26642843
99	ATR	0.26222651
100	KDR	0.24055601

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	4.27520264
2	Phototransduction_Homo sapiens_hsa04744	3.90431100
3	Protein export_Homo sapiens_hsa03060	3.84940126
4	Mismatch repair_Homo sapiens_hsa03430	3.26143535
5	Propanoate metabolism_Homo sapiens_hsa00640	2.84342971
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.51004123
7	Homologous recombination_Homo sapiens_hsa03440	2.17690852
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98420682
9	Selenocompound metabolism_Homo sapiens_hsa00450	1.89975144
10	Oxidative phosphorylation_Homo sapiens_hsa00190	1.88358888
11	Regulation of autophagy_Homo sapiens_hsa04140	1.84098811
12	Proteasome_Homo sapiens_hsa03050	1.76351125
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.75189765
14	RNA degradation_Homo sapiens_hsa03018	1.63729360
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.61925706
16	Mineral absorption_Homo sapiens_hsa04978	1.57726626
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.56817354
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.53779695
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.53020590
20	Parkinsons disease_Homo sapiens_hsa05012	1.52839102
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52158005
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.42822527
23	Fatty acid elongation_Homo sapiens_hsa00062	1.35818957
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.35562669
25	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.33182102
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.32640988
27	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.32141733
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30821815
29	Purine metabolism_Homo sapiens_hsa00230	1.29068483
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28321987
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.27938866
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.27667926
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.24612149
34	Olfactory transduction_Homo sapiens_hsa04740	1.18984457
35	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.13207424
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13170762
37	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.12709829
38	Glutathione metabolism_Homo sapiens_hsa00480	1.12297779
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.06292388
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05740276
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03889907
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03558888
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01946200
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01695510
45	Sulfur metabolism_Homo sapiens_hsa00920	1.01184454
46	Taste transduction_Homo sapiens_hsa04742	0.99926359
47	Butanoate metabolism_Homo sapiens_hsa00650	0.98120343
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96387552
49	One carbon pool by folate_Homo sapiens_hsa00670	0.95772103
50	Caffeine metabolism_Homo sapiens_hsa00232	0.95334588
51	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92639546
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89870749
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.87331536
54	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.87193119
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86299605
56	Peroxisome_Homo sapiens_hsa04146	0.84270985
57	RNA polymerase_Homo sapiens_hsa03020	0.83427024
58	Legionellosis_Homo sapiens_hsa05134	0.82198172
59	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.81176065
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78240436
61	Nicotine addiction_Homo sapiens_hsa05033	0.77672234
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.77415423
63	Folate biosynthesis_Homo sapiens_hsa00790	0.75166128
64	Basal transcription factors_Homo sapiens_hsa03022	0.74202155
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.73598912
66	Cardiac muscle contraction_Homo sapiens_hsa04260	0.72868207
67	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.72517351
68	Pyruvate metabolism_Homo sapiens_hsa00620	0.70701078
69	GABAergic synapse_Homo sapiens_hsa04727	0.70643693
70	Metabolic pathways_Homo sapiens_hsa01100	0.70580698
71	DNA replication_Homo sapiens_hsa03030	0.70264769
72	Circadian rhythm_Homo sapiens_hsa04710	0.66212420
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66022214
74	Huntingtons disease_Homo sapiens_hsa05016	0.63515602
75	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.62303973
76	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.60515021
77	Retinol metabolism_Homo sapiens_hsa00830	0.60051452
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59668728
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.58029159
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56756718
81	p53 signaling pathway_Homo sapiens_hsa04115	0.52434475
82	RNA transport_Homo sapiens_hsa03013	0.51594175
83	Alzheimers disease_Homo sapiens_hsa05010	0.51269840
84	Oocyte meiosis_Homo sapiens_hsa04114	0.50028370
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.49277755
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.47604791
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47439501
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45016129
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43185485
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.42847361
91	Cocaine addiction_Homo sapiens_hsa05030	0.42668959
92	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.40141387
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36424686
94	Salivary secretion_Homo sapiens_hsa04970	0.35124138
95	Vibrio cholerae infection_Homo sapiens_hsa05110	0.34034576
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.32974327
97	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.32944127
98	Serotonergic synapse_Homo sapiens_hsa04726	0.32845527
99	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.31915007
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.30602157

NDUFA5P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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