NDUFA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LYR family of proteins that contain a highly conserved tripeptide (LYR) motif near the N-terminus. The encoded protein is an accessory subunit of NADH: ubiquinone oxidorerductase (Complex I), which is the largest enzyme of the mitochondrial membrane respiratory chain. Complex I functions in electron transfer from NADH to the respiratory chain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.33900401
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.89877321
3ATP synthesis coupled proton transport (GO:0015986)8.89877321
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.58287874
5* respiratory electron transport chain (GO:0022904)8.01518596
6* electron transport chain (GO:0022900)7.80973006
7oxidative phosphorylation (GO:0006119)5.43796484
8ATP biosynthetic process (GO:0006754)5.13994256
9protein complex biogenesis (GO:0070271)4.78286446
10purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.69073051
11hydrogen ion transmembrane transport (GO:1902600)4.67869768
12purine nucleoside triphosphate biosynthetic process (GO:0009145)4.67262431
13maturation of SSU-rRNA (GO:0030490)4.67056642
14inner mitochondrial membrane organization (GO:0007007)4.59652887
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.52678013
16NADH dehydrogenase complex assembly (GO:0010257)4.52678013
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.52678013
18proteasome assembly (GO:0043248)4.42400746
19mitochondrial respiratory chain complex assembly (GO:0033108)4.36989755
20proton transport (GO:0015992)4.12460491
21ribonucleoside triphosphate biosynthetic process (GO:0009201)4.10922118
22hydrogen transport (GO:0006818)4.06987014
23ribosomal small subunit biogenesis (GO:0042274)4.04307728
24cellular ketone body metabolic process (GO:0046950)4.01817588
25translational initiation (GO:0006413)4.01013583
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.96558493
27viral transcription (GO:0019083)3.95894638
28protein neddylation (GO:0045116)3.94912671
29tricarboxylic acid cycle (GO:0006099)3.92430266
30chaperone-mediated protein transport (GO:0072321)3.91862984
31ribosomal large subunit biogenesis (GO:0042273)3.86228336
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.86131206
33termination of RNA polymerase III transcription (GO:0006386)3.86131206
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.85904468
35chromatin remodeling at centromere (GO:0031055)3.82605978
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.77559618
37translational termination (GO:0006415)3.75386184
38CENP-A containing nucleosome assembly (GO:0034080)3.75085636
39L-phenylalanine catabolic process (GO:0006559)3.75051869
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.75051869
41aerobic respiration (GO:0009060)3.68311029
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.66460025
43L-phenylalanine metabolic process (GO:0006558)3.66460025
44cotranslational protein targeting to membrane (GO:0006613)3.64285870
45protein targeting to ER (GO:0045047)3.63724105
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63673550
47ribosomal small subunit assembly (GO:0000028)3.62965759
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.62464793
49regulation of oxidative phosphorylation (GO:0002082)3.60405379
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59584799
51aldehyde catabolic process (GO:0046185)3.54147602
52succinate metabolic process (GO:0006105)3.53646428
53respiratory chain complex IV assembly (GO:0008535)3.52030261
54protein localization to endoplasmic reticulum (GO:0070972)3.51305595
55nucleoside triphosphate biosynthetic process (GO:0009142)3.51288519
56ketone body metabolic process (GO:1902224)3.50988454
57cullin deneddylation (GO:0010388)3.47431979
58establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47402396
59protein complex disassembly (GO:0043241)3.46064307
60branched-chain amino acid catabolic process (GO:0009083)3.44302056
61water-soluble vitamin biosynthetic process (GO:0042364)3.38769148
62regulation of mitochondrial translation (GO:0070129)3.37994379
63NADH metabolic process (GO:0006734)3.37031814
64sequestering of actin monomers (GO:0042989)3.33508166
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32760368
66macromolecular complex disassembly (GO:0032984)3.32540064
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31407362
68DNA damage response, detection of DNA damage (GO:0042769)3.28079254
69cellular component biogenesis (GO:0044085)3.27223887
70cytochrome complex assembly (GO:0017004)3.27136160
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26584283
72negative regulation of ligase activity (GO:0051352)3.26584283
73protein targeting to membrane (GO:0006612)3.21424301
74mitochondrial transport (GO:0006839)3.18729517
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17626165
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17626165
77regulation of cellular amino acid metabolic process (GO:0006521)3.17331772
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15618984
79rRNA modification (GO:0000154)3.12443378
80GTP biosynthetic process (GO:0006183)3.11848834
81translational elongation (GO:0006414)3.11242437
82quinone biosynthetic process (GO:1901663)3.10813459
83ubiquinone biosynthetic process (GO:0006744)3.10813459
84cytidine metabolic process (GO:0046087)3.10374116
85cytidine catabolic process (GO:0006216)3.10374116
86cytidine deamination (GO:0009972)3.10374116
87protein deneddylation (GO:0000338)3.09095105
88nuclear-transcribed mRNA catabolic process (GO:0000956)3.07854752
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07722095
90glyoxylate metabolic process (GO:0046487)3.07644778
91* generation of precursor metabolites and energy (GO:0006091)3.05485967
92spliceosomal snRNP assembly (GO:0000387)3.04879534
93short-chain fatty acid metabolic process (GO:0046459)3.04040000
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03031574
95histone exchange (GO:0043486)3.03014044
96kinetochore assembly (GO:0051382)3.02938811
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00899703
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00899703
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00899703
100viral life cycle (GO:0019058)3.00640634
101purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.99736476
102purine nucleoside monophosphate biosynthetic process (GO:0009127)2.99736476
103fatty acid beta-oxidation (GO:0006635)2.98522518
104intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97725540
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97725540
106pseudouridine synthesis (GO:0001522)2.97604765
107branched-chain amino acid metabolic process (GO:0009081)2.97402387
108cellular respiration (GO:0045333)2.93348733
109fatty acid catabolic process (GO:0009062)2.92221973
110platelet dense granule organization (GO:0060155)2.92180788
111aromatic amino acid family catabolic process (GO:0009074)2.91923912
112mRNA catabolic process (GO:0006402)2.88701037
113cellular protein complex disassembly (GO:0043624)2.88589103
114signal transduction involved in DNA damage checkpoint (GO:0072422)2.88263068
115signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88263068
116signal transduction involved in cell cycle checkpoint (GO:0072395)2.86108035
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85976078
118rRNA processing (GO:0006364)2.84047314
119purine nucleoside biosynthetic process (GO:0042451)2.83658640
120purine ribonucleoside biosynthetic process (GO:0046129)2.83658640
121ubiquinone metabolic process (GO:0006743)2.80538387
122DNA replication checkpoint (GO:0000076)2.79872226
123ribonucleoprotein complex biogenesis (GO:0022613)2.78417503
124heart contraction (GO:0060047)2.75910085
125heart process (GO:0003015)2.75910085
126fatty acid oxidation (GO:0019395)2.74942264
127regulation of cellular respiration (GO:0043457)2.72692067
128lipid oxidation (GO:0034440)2.70489361
129monocarboxylic acid catabolic process (GO:0072329)2.68326317
130protein targeting to mitochondrion (GO:0006626)2.64818151
131intracellular protein transmembrane import (GO:0044743)2.62075015
132oxaloacetate metabolic process (GO:0006107)2.59399790
133translation (GO:0006412)2.58534379
134acetyl-CoA metabolic process (GO:0006084)2.58348534
135dopamine transport (GO:0015872)2.57573444
136aspartate family amino acid catabolic process (GO:0009068)2.55908478
137cofactor catabolic process (GO:0051187)2.55331087
138negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.55258912
139establishment of protein localization to mitochondrion (GO:0072655)2.55010293
140coenzyme catabolic process (GO:0009109)2.54961200
141lysine catabolic process (GO:0006554)2.53971761
142lysine metabolic process (GO:0006553)2.53971761
143regulation of acyl-CoA biosynthetic process (GO:0050812)2.52959494
144glutathione metabolic process (GO:0006749)2.50567179
145fatty acid elongation (GO:0030497)2.50512277
146alkaloid metabolic process (GO:0009820)2.50396798
147thioester metabolic process (GO:0035383)2.50003154
148acyl-CoA metabolic process (GO:0006637)2.50003154
149protein localization to mitochondrion (GO:0070585)2.47717932
150protein-cofactor linkage (GO:0018065)2.46657451
151ribonucleoside monophosphate biosynthetic process (GO:0009156)2.45241754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.44344891
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.29357307
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.21877711
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31183479
5* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.11763706
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.06864537
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04272220
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.81386234
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.77586137
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.68640797
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64396661
12* RXR_22158963_ChIP-Seq_LIVER_Mouse2.57671472
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55416758
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54356821
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54146226
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51234967
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.51222240
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30387661
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29120794
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.28644174
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28363402
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.22833484
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.20242768
24* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18842218
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.12104411
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.09898702
27VDR_22108803_ChIP-Seq_LS180_Human2.07893534
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05083622
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02699440
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02344896
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99495198
32* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98453553
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97959178
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93764730
35E2F7_22180533_ChIP-Seq_HELA_Human1.92526330
36* LXR_22158963_ChIP-Seq_LIVER_Mouse1.79537526
37EZH2_22144423_ChIP-Seq_EOC_Human1.77889443
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77351238
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73191871
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60209873
41EWS_26573619_Chip-Seq_HEK293_Human1.54797369
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46025435
43* GABP_19822575_ChIP-Seq_HepG2_Human1.45367096
44ZNF274_21170338_ChIP-Seq_K562_Hela1.43382933
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41192178
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39704773
47HTT_18923047_ChIP-ChIP_STHdh_Human1.38383826
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37491012
49FUS_26573619_Chip-Seq_HEK293_Human1.35720274
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33904772
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33798733
52* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31329653
53* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29964057
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29411299
55TAF15_26573619_Chip-Seq_HEK293_Human1.26908341
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24194600
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23577171
58* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22746348
59DCP1A_22483619_ChIP-Seq_HELA_Human1.21943772
60* YY1_21170310_ChIP-Seq_MESCs_Mouse1.21578139
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.21510004
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.21174568
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20339998
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.19539426
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.18066099
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17966179
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15977470
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13609029
69* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12461423
70IRF1_19129219_ChIP-ChIP_H3396_Human1.12405078
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12065279
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11579720
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11556479
74* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10019679
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09897026
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09886796
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08352369
78TP53_22573176_ChIP-Seq_HFKS_Human1.08290344
79BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08135791
80* VDR_23849224_ChIP-Seq_CD4+_Human1.07657007
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07022008
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06857381
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05729269
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05433050
85NANOG_20526341_ChIP-Seq_ESCs_Human1.04582639
86IGF1R_20145208_ChIP-Seq_DFB_Human1.03624736
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02186402
88ELK1_19687146_ChIP-ChIP_HELA_Human0.99579516
89* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99484486
90P300_19829295_ChIP-Seq_ESCs_Human0.97546089
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96707964
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96397898
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96312734
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95400494
95ERG_20517297_ChIP-Seq_VCAP_Human0.94786666
96MYC_18555785_ChIP-Seq_MESCs_Mouse0.93733527
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93320895
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92581087
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91627550
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89427101
101E2F1_21310950_ChIP-Seq_MCF-7_Human0.88824545
102PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88531893
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88282940
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87506944
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86862800
106NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86478274
107FOXP3_21729870_ChIP-Seq_TREG_Human0.86132400
108CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84773714
109MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83607344
110AR_20517297_ChIP-Seq_VCAP_Human0.83531762
111STAT1_20625510_ChIP-Seq_HELA_Human0.83151294
112KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82059289
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80437651
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80143079
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79972832
116* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79845795
117MYC_18940864_ChIP-ChIP_HL60_Human0.79763270
118FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79628686
119FOXA1_25329375_ChIP-Seq_VCAP_Human0.79628686
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78233094
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77941090
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77850018
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77587538
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77215409
125TAF2_19829295_ChIP-Seq_ESCs_Human0.77051033
126CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75681638
127* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.73836111
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.73772319
129NANOG_19829295_ChIP-Seq_ESCs_Human0.73066347
130SOX2_19829295_ChIP-Seq_ESCs_Human0.73066347
131NCOR_22424771_ChIP-Seq_293T_Human0.72079252
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71088883
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70455574
134TTF2_22483619_ChIP-Seq_HELA_Human0.69681903
135EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.66942000
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.66661575
137MYC_19829295_ChIP-Seq_ESCs_Human0.66636072
138* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.65554513
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.65414573
140XRN2_22483619_ChIP-Seq_HELA_Human0.63678109
141CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.63394948
142ER_23166858_ChIP-Seq_MCF-7_Human0.62980738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.43200538
2MP0002139_abnormal_hepatobiliary_system3.60981044
3MP0005360_urolithiasis3.45257828
4MP0006036_abnormal_mitochondrial_physio3.35513270
5MP0005085_abnormal_gallbladder_physiolo3.32931031
6MP0009379_abnormal_foot_pigmentation3.32008565
7MP0003806_abnormal_nucleotide_metabolis3.26262682
8MP0003646_muscle_fatigue3.25828754
9MP0006292_abnormal_olfactory_placode3.25468423
10MP0008875_abnormal_xenobiotic_pharmacok2.98857288
11MP0003195_calcinosis2.91169182
12MP0005365_abnormal_bile_salt2.52324068
13MP0002938_white_spotting2.33979586
14MP0005083_abnormal_biliary_tract2.33006668
15MP0006035_abnormal_mitochondrial_morpho2.30936337
16MP0003186_abnormal_redox_activity2.29382275
17MP0003718_maternal_effect2.28062495
18MP0001529_abnormal_vocalization2.26600183
19MP0008058_abnormal_DNA_repair2.22898835
20MP0004043_abnormal_pH_regulation2.22624148
21MP0005332_abnormal_amino_acid2.15981113
22MP0004036_abnormal_muscle_relaxation2.14209970
23MP0004215_abnormal_myocardial_fiber2.12983900
24MP0000751_myopathy2.11063543
25MP0000749_muscle_degeneration2.07843915
26MP0004957_abnormal_blastocyst_morpholog1.87306220
27MP0010030_abnormal_orbit_morphology1.86231129
28MP0002102_abnormal_ear_morphology1.84840973
29MP0004084_abnormal_cardiac_muscle1.83548539
30MP0005330_cardiomyopathy1.79374295
31MP0006072_abnormal_retinal_apoptosis1.78758282
32MP0003693_abnormal_embryo_hatching1.77489775
33MP0006276_abnormal_autonomic_nervous1.70996847
34MP0005636_abnormal_mineral_homeostasis1.67661307
35MP0005084_abnormal_gallbladder_morpholo1.66684951
36MP0008789_abnormal_olfactory_epithelium1.64305450
37MP0001666_abnormal_nutrient_absorption1.61885256
38MP0010094_abnormal_chromosome_stability1.61860492
39MP0001905_abnormal_dopamine_level1.59032213
40MP0001293_anophthalmia1.57844996
41MP0002277_abnormal_respiratory_mucosa1.54908519
42MP0001764_abnormal_homeostasis1.54583072
43MP0004142_abnormal_muscle_tone1.53244629
44MP0005451_abnormal_body_composition1.51875515
45MP0008877_abnormal_DNA_methylation1.51073635
46MP0005584_abnormal_enzyme/coenzyme_acti1.45371878
47MP0004019_abnormal_vitamin_homeostasis1.45286876
48MP0003137_abnormal_impulse_conducting1.44574003
49MP0001485_abnormal_pinna_reflex1.43376068
50MP0005535_abnormal_body_temperature1.42320953
51MP0008932_abnormal_embryonic_tissue1.41460832
52MP0002972_abnormal_cardiac_muscle1.40433317
53MP0005646_abnormal_pituitary_gland1.39624800
54MP0002234_abnormal_pharynx_morphology1.33915580
55MP0000631_abnormal_neuroendocrine_gland1.32412786
56MP0010329_abnormal_lipoprotein_level1.32079804
57MP0009643_abnormal_urine_homeostasis1.32025170
58MP0004147_increased_porphyrin_level1.30294102
59MP0003880_abnormal_central_pattern1.29835034
60MP0002638_abnormal_pupillary_reflex1.29179894
61MP0005394_taste/olfaction_phenotype1.29090369
62MP0005499_abnormal_olfactory_system1.29090369
63MP0005551_abnormal_eye_electrophysiolog1.28637551
64MP0002653_abnormal_ependyma_morphology1.27287622
65MP0004484_altered_response_of1.26933786
66MP0002876_abnormal_thyroid_physiology1.24984167
67MP0005620_abnormal_muscle_contractility1.22772058
68MP0002822_catalepsy1.22662254
69MP0002160_abnormal_reproductive_system1.21764601
70MP0002118_abnormal_lipid_homeostasis1.21427536
71MP0005253_abnormal_eye_physiology1.19863540
72MP0003077_abnormal_cell_cycle1.18429363
73MP0002332_abnormal_exercise_endurance1.17462576
74MP0003121_genomic_imprinting1.16974066
75MP0009046_muscle_twitch1.16804340
76MP0003890_abnormal_embryonic-extraembry1.16312696
77MP0003941_abnormal_skin_development1.15844246
78MP0002736_abnormal_nociception_after1.15663212
79MP0010386_abnormal_urinary_bladder1.14059154
80MP0000230_abnormal_systemic_arterial1.13861827
81MP0002138_abnormal_hepatobiliary_system1.13615024
82MP0005266_abnormal_metabolism1.11928161
83MP0008995_early_reproductive_senescence1.11895760
84MP0003252_abnormal_bile_duct1.10595193
85MP0005319_abnormal_enzyme/_coenzyme1.10449861
86MP0004145_abnormal_muscle_electrophysio1.10262366
87MP0005379_endocrine/exocrine_gland_phen1.10118291
88MP0009840_abnormal_foam_cell1.08979261
89MP0000049_abnormal_middle_ear1.07749965
90MP0004133_heterotaxia1.05917764
91MP0002210_abnormal_sex_determination1.05357595
92MP0004130_abnormal_muscle_cell1.03604150
93MP0005385_cardiovascular_system_phenoty1.03105926
94MP0001544_abnormal_cardiovascular_syste1.03105926
95MP0005389_reproductive_system_phenotype1.02751930
96MP0001765_abnormal_ion_homeostasis1.01949335
97MP0009745_abnormal_behavioral_response0.99062744
98MP0003787_abnormal_imprinting0.98973579
99MP0003111_abnormal_nucleus_morphology0.98932355
100MP0002106_abnormal_muscle_physiology0.97755241
101MP0008775_abnormal_heart_ventricle0.96451334
102MP0003786_premature_aging0.94862433
103MP0004085_abnormal_heartbeat0.94248119
104MP0003567_abnormal_fetal_cardiomyocyte0.93995064
105MP0005376_homeostasis/metabolism_phenot0.93664566
106MP0008872_abnormal_physiological_respon0.92482829
107MP0005645_abnormal_hypothalamus_physiol0.92467868
108MP0002090_abnormal_vision0.91493960
109MP0003123_paternal_imprinting0.90653713
110MP0005408_hypopigmentation0.90584023
111MP0003122_maternal_imprinting0.89984493
112MP0001986_abnormal_taste_sensitivity0.89976166
113MP0002132_abnormal_respiratory_system0.89809187
114MP0003937_abnormal_limbs/digits/tail_de0.89574363
115MP0002095_abnormal_skin_pigmentation0.89083725
116MP0005410_abnormal_fertilization0.88923502
117MP0005165_increased_susceptibility_to0.87534413
118MP0003938_abnormal_ear_development0.86472223
119MP0009697_abnormal_copulation0.86395244
120MP0003724_increased_susceptibility_to0.86287606
121MP0000013_abnormal_adipose_tissue0.85543868
122MP0003136_yellow_coat_color0.85535904
123MP0003656_abnormal_erythrocyte_physiolo0.85180390
124MP0000372_irregular_coat_pigmentation0.84643021
125MP0003315_abnormal_perineum_morphology0.84503017
126MP0000750_abnormal_muscle_regeneration0.83877380
127MP0002233_abnormal_nose_morphology0.82615454
128MP0002272_abnormal_nervous_system0.82463403
129MP0001756_abnormal_urination0.82060291
130MP0000026_abnormal_inner_ear0.81674388
131MP0002078_abnormal_glucose_homeostasis0.80950163
132MP0002163_abnormal_gland_morphology0.80898750
133MP0004087_abnormal_muscle_fiber0.80300885
134MP0001286_abnormal_eye_development0.80079826
135MP0001440_abnormal_grooming_behavior0.80013169
136MP0001664_abnormal_digestion0.79884441
137MP0000538_abnormal_urinary_bladder0.79338457
138MP0000653_abnormal_sex_gland0.78461132
139MP0001968_abnormal_touch/_nociception0.77822843
140MP0005195_abnormal_posterior_eye0.77410006
141MP0005369_muscle_phenotype0.76700844
142MP0000747_muscle_weakness0.76449580
143MP0002752_abnormal_somatic_nervous0.75972824
144MP0001929_abnormal_gametogenesis0.74745345
145MP0008007_abnormal_cellular_replicative0.74441154
146MP0001145_abnormal_male_reproductive0.72629132
147MP0001919_abnormal_reproductive_system0.71714645
148MP0002734_abnormal_mechanical_nocicepti0.70983416
149MP0004381_abnormal_hair_follicle0.70722620
150MP0003011_delayed_dark_adaptation0.68956636
151MP0002148_abnormal_hypersensitivity_rea0.68833614
152MP0001984_abnormal_olfaction0.67854245
153MP0001727_abnormal_embryo_implantation0.67630008
154MP0002735_abnormal_chemical_nociception0.67184432
155MP0004924_abnormal_behavior0.66791164
156MP0005386_behavior/neurological_phenoty0.66791164
157MP0003191_abnormal_cellular_cholesterol0.66414795
158MP0008469_abnormal_protein_level0.65559230
159MP0000609_abnormal_liver_physiology0.65290310
160MP0002971_abnormal_brown_adipose0.64549666

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.12150877
2Abnormal mitochondria in muscle tissue (HP:0008316)6.63828168
3Acute encephalopathy (HP:0006846)6.33024179
4Mitochondrial inheritance (HP:0001427)6.13914190
5Progressive macrocephaly (HP:0004481)5.96857374
6Increased CSF lactate (HP:0002490)5.36558139
7Hepatocellular necrosis (HP:0001404)5.34760215
8Hepatic necrosis (HP:0002605)5.32529468
9Cerebral edema (HP:0002181)5.12800224
10Increased hepatocellular lipid droplets (HP:0006565)4.70566597
11Lipid accumulation in hepatocytes (HP:0006561)4.66036952
12Increased intramyocellular lipid droplets (HP:0012240)4.31353018
13Renal Fanconi syndrome (HP:0001994)4.23334726
14Increased muscle lipid content (HP:0009058)4.13114566
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.10921591
16Lactic acidosis (HP:0003128)4.03609031
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.95053330
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.95053330
19Respiratory failure (HP:0002878)3.85209543
20Exercise intolerance (HP:0003546)3.75893436
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.51748494
22Optic disc pallor (HP:0000543)3.51018751
23Leukodystrophy (HP:0002415)3.45210098
243-Methylglutaconic aciduria (HP:0003535)3.32653479
25Abnormality of glycolysis (HP:0004366)3.31993162
26Increased serum pyruvate (HP:0003542)3.31993162
27Increased serum lactate (HP:0002151)3.28045524
28Lethargy (HP:0001254)3.25520048
29Abnormality of aromatic amino acid family metabolism (HP:0004338)3.23223538
30Abnormality of urine glucose concentration (HP:0011016)3.18966900
31Glycosuria (HP:0003076)3.18966900
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.13052871
33Dicarboxylic aciduria (HP:0003215)3.13052871
34Exertional dyspnea (HP:0002875)3.11505374
35Abnormality of renal resorption (HP:0011038)3.01596060
36Abnormality of cells of the erythroid lineage (HP:0012130)2.84688680
37Generalized aminoaciduria (HP:0002909)2.83290765
38Abnormality of fatty-acid metabolism (HP:0004359)2.81670333
39Septo-optic dysplasia (HP:0100842)2.78619913
40Respiratory difficulties (HP:0002880)2.74949857
41Hyperphosphaturia (HP:0003109)2.72940754
42Calf muscle hypertrophy (HP:0008981)2.67418184
43Congenital, generalized hypertrichosis (HP:0004540)2.67010140
44Palpitations (HP:0001962)2.64935870
45Muscle hypertrophy of the lower extremities (HP:0008968)2.63068933
46Hypoglycemic coma (HP:0001325)2.62030939
47Colon cancer (HP:0003003)2.60966467
48Vomiting (HP:0002013)2.55646072
49Sudden death (HP:0001699)2.53061699
50Pheochromocytoma (HP:0002666)2.51105123
51Ketoacidosis (HP:0001993)2.50919582
52Neuroendocrine neoplasm (HP:0100634)2.50687162
53Abnormality of the labia minora (HP:0012880)2.49133394
54Abnormal number of erythroid precursors (HP:0012131)2.46852750
55Pancreatic cysts (HP:0001737)2.46772901
56CNS demyelination (HP:0007305)2.45700758
57Pancreatic fibrosis (HP:0100732)2.45327069
58Ketosis (HP:0001946)2.42788634
59Myoglobinuria (HP:0002913)2.42056703
60Molar tooth sign on MRI (HP:0002419)2.38955676
61Abnormality of midbrain morphology (HP:0002418)2.38955676
62X-linked dominant inheritance (HP:0001423)2.36910213
63Methylmalonic aciduria (HP:0012120)2.36255610
64Pallor (HP:0000980)2.34486870
65Abnormal urine phosphate concentration (HP:0012599)2.32893949
66True hermaphroditism (HP:0010459)2.28785399
67Metabolic acidosis (HP:0001942)2.28607172
68Conjunctival hamartoma (HP:0100780)2.26040166
69Exercise-induced myalgia (HP:0003738)2.24504375
70Hyperammonemia (HP:0001987)2.20550754
71Hyperglycinuria (HP:0003108)2.20537094
72Proximal tubulopathy (HP:0000114)2.18052991
73Myokymia (HP:0002411)2.17408830
74Abnormality of the anterior horn cell (HP:0006802)2.16767624
75Degeneration of anterior horn cells (HP:0002398)2.16767624
76Rhabdomyolysis (HP:0003201)2.12510853
77Macrocytic anemia (HP:0001972)2.09317038
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08669023
79Renal tubular dysfunction (HP:0000124)2.06264161
80Absent septum pellucidum (HP:0001331)2.03329428
81Prolonged partial thromboplastin time (HP:0003645)2.03279238
82Methylmalonic acidemia (HP:0002912)2.02932941
83Ragged-red muscle fibers (HP:0003200)2.00438150
84Type I transferrin isoform profile (HP:0003642)2.00227463
85Sclerocornea (HP:0000647)1.98946087
86Abnormality of serine family amino acid metabolism (HP:0010894)1.98366016
87Abnormality of glycine metabolism (HP:0010895)1.98366016
88Megaloblastic anemia (HP:0001889)1.98363095
89Ventricular tachycardia (HP:0004756)1.98016261
90Intrahepatic cholestasis (HP:0001406)1.96758718
91Emotional lability (HP:0000712)1.96441588
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96364268
93Esophageal neoplasm (HP:0100751)1.95553728
94Neoplasm of head and neck (HP:0012288)1.95553728
95Muscle stiffness (HP:0003552)1.93441463
96Abnormality of alanine metabolism (HP:0010916)1.91320859
97Hyperalaninemia (HP:0003348)1.91320859
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91320859
99Absent thumb (HP:0009777)1.91214793
100Aplastic anemia (HP:0001915)1.90873694
101Medial flaring of the eyebrow (HP:0010747)1.88793631
102Hypoplasia of the pons (HP:0012110)1.88265982
103Abnormality of the pons (HP:0007361)1.87554406
104Nausea (HP:0002018)1.86761581
105Exercise-induced muscle cramps (HP:0003710)1.86703798
106Nephronophthisis (HP:0000090)1.86604532
107Cerebral hemorrhage (HP:0001342)1.86274589
108Renal cortical cysts (HP:0000803)1.85303869
109Hypothermia (HP:0002045)1.85031472
110Abnormality of serum amino acid levels (HP:0003112)1.85027257
111Abnormal hemoglobin (HP:0011902)1.82668074
112Oral leukoplakia (HP:0002745)1.81469362
113Optic nerve hypoplasia (HP:0000609)1.81302661
114Meckel diverticulum (HP:0002245)1.80014565
115Hyperglycinemia (HP:0002154)1.78512333
116Myotonia (HP:0002486)1.76438716
117Gliosis (HP:0002171)1.75830462
118Reticulocytopenia (HP:0001896)1.75668458
119Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75527764
120Maternal diabetes (HP:0009800)1.75291844
121Xanthomatosis (HP:0000991)1.74039829
122Hyperlipoproteinemia (HP:0010980)1.73534732
123Hypobetalipoproteinemia (HP:0003563)1.73484319
124Abnormality of the ileum (HP:0001549)1.72411837
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.70776875
126Microvesicular hepatic steatosis (HP:0001414)1.69002857
127Abnormality of the calf musculature (HP:0001430)1.68919533
128Abnormality of methionine metabolism (HP:0010901)1.68739538
129Lipoatrophy (HP:0100578)1.68577926
130Pendular nystagmus (HP:0012043)1.68421004
131Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68108230
132Dilated cardiomyopathy (HP:0001644)1.66517108
133Pancytopenia (HP:0001876)1.65512647
134Triphalangeal thumb (HP:0001199)1.65283663
135Male pseudohermaphroditism (HP:0000037)1.65231155
136Syncope (HP:0001279)1.64334685
137Aplasia/hypoplasia of the uterus (HP:0008684)1.63808223
138Stenosis of the external auditory canal (HP:0000402)1.63617818
139Abnormality of the septum pellucidum (HP:0007375)1.60246665
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.59943282
141Muscle fiber splitting (HP:0003555)1.57916307
142Blindness (HP:0000618)1.57495756
143Abnormal pupillary function (HP:0007686)1.55961389
144Anencephaly (HP:0002323)1.54359528
145Abnormality of placental membranes (HP:0011409)1.54056033
146Amniotic constriction ring (HP:0009775)1.54056033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.63573391
2NME23.93608556
3BCKDK3.79601209
4NME13.72369431
5MYLK3.43467539
6BUB13.14091700
7MAP3K122.80860725
8OBSCN2.74771406
9MUSK2.66061949
10STK162.54562384
11CDC72.53977125
12ARAF2.53114348
13WNK42.41511658
14GRK72.20145949
15STK392.14489720
16TAOK32.10310738
17MST42.04673642
18NUAK11.90765037
19TAF11.88828062
20MAP4K21.78617881
21PLK31.76367237
22EIF2AK11.74963638
23PBK1.73689355
24NEK11.71502602
25PDK41.70622654
26PDK31.70622654
27OXSR11.64045241
28CASK1.62040738
29PIK3CA1.61630811
30PINK11.60708245
31PLK41.58288759
32GRK51.57745963
33PHKG11.55885783
34PHKG21.55885783
35WNK31.46743886
36PIK3CG1.45396660
37SRPK11.45329581
38LMTK21.45192195
39MST1R1.44429341
40PDK21.43242636
41MAPK151.39980992
42PIM21.39550947
43WEE11.34942621
44ADRBK21.27870175
45TRIM281.25831890
46CAMK2D1.22772563
47MAPKAPK51.16360420
48PLK21.13937576
49TTK1.11573321
50ABL21.08830328
51PLK11.08409743
52VRK11.07064665
53ILK1.05871269
54CAMK2G1.05527188
55BMPR21.03833501
56TIE11.00402744
57BMPR1B0.98900322
58CSNK1G20.94705028
59BRAF0.92839242
60BRSK20.92776787
61DAPK30.90145790
62TLK10.89474617
63CAMK2B0.88884153
64CCNB10.87570078
65MAP3K40.85498375
66EPHB20.84744060
67CHEK20.82998587
68STK240.81590473
69CAMK2A0.81063879
70INSRR0.80096860
71PKN10.79887396
72TTN0.79606050
73CDK190.79423771
74MKNK20.79249287
75PRKCG0.79225703
76TNIK0.78704623
77LIMK10.78654935
78AURKB0.78115528
79BCR0.76633952
80MAP2K70.76028674
81DYRK30.75934602
82MKNK10.75334455
83MAP2K20.70876369
84AURKA0.70828262
85ADRBK10.70072167
86PRKACA0.68557938
87IRAK30.68031312
88CSNK2A20.65211363
89IRAK20.65192538
90KDR0.65150725
91PRKCE0.63906052
92PNCK0.63847306
93MAPK130.62930486
94MAP2K60.61288966
95CSNK1G30.60596887
96DYRK20.58609411
97ZAK0.58384288
98MAP3K110.57637213
99MINK10.57482448
100MAPK120.57009942
101PAK30.56506231
102FRK0.55713101
103MAP2K40.55166539
104CSNK1A1L0.53951396
105EIF2AK30.53867291
106GRK60.53188433
107ACVR1B0.52980329
108BRSK10.52695820
109ATR0.51809164
110STK40.51242269
111MAP3K30.50771969
112TEC0.50596657
113PASK0.49915431
114PRKG20.49309087
115CDK80.48375993
116PRKCQ0.47825734
117CSNK1E0.47324546
118CSNK1A10.46967884
119MAPK40.46654742
120DAPK10.45934671
121STK38L0.43135456
122TSSK60.42113237
123MAPKAPK30.40375813
124GRK10.39567158
125EIF2AK20.38663317
126PRKACG0.36473799
127UHMK10.36258695
128MARK10.35933698
129EPHA40.35744381
130PAK10.35566680
131ERBB30.35501820
132PRKCA0.34635775
133IRAK10.34133696
134CSNK1G10.34066813
135CSNK2A10.33079692
136CAMK10.31866876
137PRKCD0.29584473
138ROCK20.29396653
139PRKAA20.28159610
140IRAK40.26761453
141PRKD10.26534128
142RPS6KA50.26391973
143RPS6KC10.26204814
144RPS6KL10.26204814
145PRKG10.25707932
146TBK10.25287453
147PRKACB0.24327055
148ERBB40.24184812
149RPS6KA60.23376306

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.66084244
2Parkinsons disease_Homo sapiens_hsa050124.88042958
3Alzheimers disease_Homo sapiens_hsa050103.66128937
4* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.32007791
5Huntingtons disease_Homo sapiens_hsa050163.25520731
6Ribosome_Homo sapiens_hsa030102.97944208
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69442430
8Cardiac muscle contraction_Homo sapiens_hsa042602.67911095
9Propanoate metabolism_Homo sapiens_hsa006402.42401439
10Mismatch repair_Homo sapiens_hsa034302.41823671
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40345857
12Sulfur metabolism_Homo sapiens_hsa009202.31398475
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25822676
14DNA replication_Homo sapiens_hsa030302.16278248
15Homologous recombination_Homo sapiens_hsa034402.14225950
16Fatty acid elongation_Homo sapiens_hsa000622.06626182
17Protein export_Homo sapiens_hsa030601.95477148
18Pyruvate metabolism_Homo sapiens_hsa006201.87321046
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87030479
20Butanoate metabolism_Homo sapiens_hsa006501.82466667
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81877308
22Fatty acid degradation_Homo sapiens_hsa000711.79925213
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65438173
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63294653
25Proteasome_Homo sapiens_hsa030501.62519149
26Spliceosome_Homo sapiens_hsa030401.55532616
27Nucleotide excision repair_Homo sapiens_hsa034201.52444336
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50913500
29Peroxisome_Homo sapiens_hsa041461.50659899
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49560735
31Basal transcription factors_Homo sapiens_hsa030221.48622933
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43400406
33Base excision repair_Homo sapiens_hsa034101.42712577
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.42153672
35Carbon metabolism_Homo sapiens_hsa012001.39245108
36Fanconi anemia pathway_Homo sapiens_hsa034601.38224932
37RNA degradation_Homo sapiens_hsa030181.36720499
38Fatty acid metabolism_Homo sapiens_hsa012121.31657723
39One carbon pool by folate_Homo sapiens_hsa006701.30136333
40Tryptophan metabolism_Homo sapiens_hsa003801.26060831
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20960864
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16314408
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15714285
44Phenylalanine metabolism_Homo sapiens_hsa003601.15007207
45Histidine metabolism_Homo sapiens_hsa003401.14385052
46Chemical carcinogenesis_Homo sapiens_hsa052041.13496582
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12783471
48beta-Alanine metabolism_Homo sapiens_hsa004101.11366558
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09395942
50Collecting duct acid secretion_Homo sapiens_hsa049661.09262874
51Tyrosine metabolism_Homo sapiens_hsa003501.08776893
52RNA transport_Homo sapiens_hsa030131.08554803
53Folate biosynthesis_Homo sapiens_hsa007901.02911426
54* Metabolic pathways_Homo sapiens_hsa011000.99729360
55RNA polymerase_Homo sapiens_hsa030200.99475275
56Glutathione metabolism_Homo sapiens_hsa004800.98850268
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94622975
58PPAR signaling pathway_Homo sapiens_hsa033200.88832428
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.86629958
60Arginine and proline metabolism_Homo sapiens_hsa003300.85986710
61Non-homologous end-joining_Homo sapiens_hsa034500.85430944
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.85378985
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84905686
64Phototransduction_Homo sapiens_hsa047440.83398814
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80379700
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76638247
67Starch and sucrose metabolism_Homo sapiens_hsa005000.74900482
68Fat digestion and absorption_Homo sapiens_hsa049750.74478068
69Arginine biosynthesis_Homo sapiens_hsa002200.74115684
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.73448923
71Nitrogen metabolism_Homo sapiens_hsa009100.72318642
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68986091
73Steroid biosynthesis_Homo sapiens_hsa001000.67179907
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.66668534
75Linoleic acid metabolism_Homo sapiens_hsa005910.66611577
76Retinol metabolism_Homo sapiens_hsa008300.66592232
77Sulfur relay system_Homo sapiens_hsa041220.63983482
78Arachidonic acid metabolism_Homo sapiens_hsa005900.62407146
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61374220
80Pyrimidine metabolism_Homo sapiens_hsa002400.59147368
81Vibrio cholerae infection_Homo sapiens_hsa051100.56611471
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56287632
83Cell cycle_Homo sapiens_hsa041100.55966659
84Biosynthesis of amino acids_Homo sapiens_hsa012300.55857685
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46476908
86Complement and coagulation cascades_Homo sapiens_hsa046100.43221417
87Fructose and mannose metabolism_Homo sapiens_hsa000510.43143639
88Systemic lupus erythematosus_Homo sapiens_hsa053220.39790843
89Nicotine addiction_Homo sapiens_hsa050330.37992629
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37862322
91Pentose phosphate pathway_Homo sapiens_hsa000300.37083294
92Caffeine metabolism_Homo sapiens_hsa002320.35453998
93Basal cell carcinoma_Homo sapiens_hsa052170.35103548
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.34915472
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34334102
96Vitamin B6 metabolism_Homo sapiens_hsa007500.33641486
97Galactose metabolism_Homo sapiens_hsa000520.33625977
98Rheumatoid arthritis_Homo sapiens_hsa053230.33509709
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32170282
100Ether lipid metabolism_Homo sapiens_hsa005650.31121484
101Oocyte meiosis_Homo sapiens_hsa041140.31106945
102Bile secretion_Homo sapiens_hsa049760.30643689
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30625222
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29585236
105Purine metabolism_Homo sapiens_hsa002300.27964134
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27888559
107Regulation of autophagy_Homo sapiens_hsa041400.27739389
108Hedgehog signaling pathway_Homo sapiens_hsa043400.25985034
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24982096
110Olfactory transduction_Homo sapiens_hsa047400.24653830
111Glycerolipid metabolism_Homo sapiens_hsa005610.22184160
112Vitamin digestion and absorption_Homo sapiens_hsa049770.20814003
113Alcoholism_Homo sapiens_hsa050340.20557233
114ABC transporters_Homo sapiens_hsa020100.20311716
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17485440
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.15622590
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15018040
118Taste transduction_Homo sapiens_hsa047420.14077813
119Selenocompound metabolism_Homo sapiens_hsa004500.10653926
120Dilated cardiomyopathy_Homo sapiens_hsa054140.09797639
121Pancreatic secretion_Homo sapiens_hsa049720.09550204
122Mineral absorption_Homo sapiens_hsa049780.09349798
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07956716
124Phagosome_Homo sapiens_hsa041450.03705632
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.03358229
126Staphylococcus aureus infection_Homo sapiens_hsa051500.02833690
127Serotonergic synapse_Homo sapiens_hsa047260.02195255

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