

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 9.57419972 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 9.02986345 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 9.02986345 |
| 4 | * mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 8.15381940 |
| 5 | * respiratory electron transport chain (GO:0022904) | 7.39314962 |
| 6 | * electron transport chain (GO:0022900) | 7.21110601 |
| 7 | ribosomal small subunit biogenesis (GO:0042274) | 6.33211601 |
| 8 | viral transcription (GO:0019083) | 6.08275975 |
| 9 | translational termination (GO:0006415) | 5.75860852 |
| 10 | chaperone-mediated protein transport (GO:0072321) | 5.72137002 |
| 11 | protein neddylation (GO:0045116) | 5.53927849 |
| 12 | cotranslational protein targeting to membrane (GO:0006613) | 5.50662145 |
| 13 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.43762092 |
| 14 | protein targeting to ER (GO:0045047) | 5.41740226 |
| 15 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.17388377 |
| 16 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 5.17372566 |
| 17 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 5.17372566 |
| 18 | NADH dehydrogenase complex assembly (GO:0010257) | 5.17372566 |
| 19 | protein localization to endoplasmic reticulum (GO:0070972) | 5.17228612 |
| 20 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.16835414 |
| 21 | protein complex biogenesis (GO:0070271) | 5.16335049 |
| 22 | ribosomal small subunit assembly (GO:0000028) | 5.06866377 |
| 23 | translational elongation (GO:0006414) | 4.76601795 |
| 24 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.76264557 |
| 25 | ATP biosynthetic process (GO:0006754) | 4.69033740 |
| 26 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 4.66558112 |
| 27 | viral life cycle (GO:0019058) | 4.60198044 |
| 28 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.59574485 |
| 29 | cellular protein complex disassembly (GO:0043624) | 4.58350627 |
| 30 | proteasome assembly (GO:0043248) | 4.57940263 |
| 31 | GTP biosynthetic process (GO:0006183) | 4.57893414 |
| 32 | hydrogen ion transmembrane transport (GO:1902600) | 4.48704464 |
| 33 | central nervous system myelination (GO:0022010) | 4.45288188 |
| 34 | axon ensheathment in central nervous system (GO:0032291) | 4.45288188 |
| 35 | oxidative phosphorylation (GO:0006119) | 4.13490776 |
| 36 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.13272923 |
| 37 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 4.12579188 |
| 38 | translation (GO:0006412) | 4.03736930 |
| 39 | maturation of SSU-rRNA (GO:0030490) | 4.02238880 |
| 40 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.01150056 |
| 41 | termination of RNA polymerase III transcription (GO:0006386) | 4.01150056 |
| 42 | proton transport (GO:0015992) | 3.97833002 |
| 43 | inner mitochondrial membrane organization (GO:0007007) | 3.97342834 |
| 44 | translational initiation (GO:0006413) | 3.95586451 |
| 45 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.94463105 |
| 46 | hydrogen transport (GO:0006818) | 3.89240722 |
| 47 | UTP biosynthetic process (GO:0006228) | 3.86270200 |
| 48 | protein targeting to mitochondrion (GO:0006626) | 3.82274862 |
| 49 | establishment of protein localization to mitochondrion (GO:0072655) | 3.81060545 |
| 50 | fatty acid elongation (GO:0030497) | 3.79172215 |
| 51 | regulation of mitochondrial translation (GO:0070129) | 3.77080340 |
| 52 | respiratory chain complex IV assembly (GO:0008535) | 3.76123161 |
| 53 | protein complex disassembly (GO:0043241) | 3.73191270 |
| 54 | ribosomal large subunit biogenesis (GO:0042273) | 3.65865847 |
| 55 | protein targeting to membrane (GO:0006612) | 3.60316417 |
| 56 | macromolecular complex disassembly (GO:0032984) | 3.56488547 |
| 57 | behavioral response to nicotine (GO:0035095) | 3.56048394 |
| 58 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.54521541 |
| 59 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.46363297 |
| 60 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.46363297 |
| 61 | protein localization to mitochondrion (GO:0070585) | 3.44945000 |
| 62 | establishment of integrated proviral latency (GO:0075713) | 3.43646946 |
| 63 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.41810380 |
| 64 | mitochondrial transport (GO:0006839) | 3.40641632 |
| 65 | UTP metabolic process (GO:0046051) | 3.39886841 |
| 66 | aerobic respiration (GO:0009060) | 3.39668557 |
| 67 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.37322885 |
| 68 | pseudouridine synthesis (GO:0001522) | 3.33392146 |
| 69 | protein-cofactor linkage (GO:0018065) | 3.32760234 |
| 70 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.28904735 |
| 71 | cytochrome complex assembly (GO:0017004) | 3.27173599 |
| 72 | 7-methylguanosine mRNA capping (GO:0006370) | 3.26018478 |
| 73 | CTP metabolic process (GO:0046036) | 3.24481459 |
| 74 | CTP biosynthetic process (GO:0006241) | 3.24481459 |
| 75 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.24471853 |
| 76 | intracellular protein transmembrane import (GO:0044743) | 3.23285660 |
| 77 | establishment of viral latency (GO:0019043) | 3.20923210 |
| 78 | RNA capping (GO:0036260) | 3.20760210 |
| 79 | 7-methylguanosine RNA capping (GO:0009452) | 3.20760210 |
| 80 | rRNA modification (GO:0000154) | 3.18119348 |
| 81 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.10894699 |
| 82 | cellular component biogenesis (GO:0044085) | 3.10806753 |
| 83 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.07608024 |
| 84 | negative regulation of ligase activity (GO:0051352) | 3.07413217 |
| 85 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.07413217 |
| 86 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.05241402 |
| 87 | substantia nigra development (GO:0021762) | 3.03463987 |
| 88 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.02002399 |
| 89 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.02002399 |
| 90 | dopamine transport (GO:0015872) | 3.01364416 |
| 91 | DNA deamination (GO:0045006) | 2.99513732 |
| 92 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.98556402 |
| 93 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.98556402 |
| 94 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.98556402 |
| 95 | platelet dense granule organization (GO:0060155) | 2.97163366 |
| 96 | mitochondrion morphogenesis (GO:0070584) | 2.95905617 |
| 97 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.95820919 |
| 98 | cullin deneddylation (GO:0010388) | 2.94571827 |
| 99 | ribonucleoprotein complex biogenesis (GO:0022613) | 2.93448716 |
| 100 | regulation of oxidative phosphorylation (GO:0002082) | 2.90260023 |
| 101 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.89441102 |
| 102 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.89441102 |
| 103 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.89027605 |
| 104 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.89027605 |
| 105 | mannosylation (GO:0097502) | 2.88233483 |
| 106 | GPI anchor biosynthetic process (GO:0006506) | 2.87388125 |
| 107 | aldehyde catabolic process (GO:0046185) | 2.87194641 |
| 108 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.86236090 |
| 109 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.86110310 |
| 110 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.85195893 |
| 111 | mRNA catabolic process (GO:0006402) | 2.81674246 |
| 112 | peptidyl-histidine modification (GO:0018202) | 2.81580437 |
| 113 | DNA damage response, detection of DNA damage (GO:0042769) | 2.81389599 |
| 114 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.80886101 |
| 115 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.80851900 |
| 116 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.80067810 |
| 117 | rRNA processing (GO:0006364) | 2.75760177 |
| 118 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.71738888 |
| 119 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.68530176 |
| 120 | rRNA metabolic process (GO:0016072) | 2.67400508 |
| 121 | protein deneddylation (GO:0000338) | 2.67279994 |
| 122 | tRNA processing (GO:0008033) | 2.65930969 |
| 123 | spliceosomal snRNP assembly (GO:0000387) | 2.64878696 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.82634017 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.50596452 |
| 3 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.43126315 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.94680960 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.83632100 |
| 6 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.73430032 |
| 7 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.66597720 |
| 8 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.32931345 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.31092619 |
| 10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.31021688 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.16185405 |
| 12 | * HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.14992966 |
| 13 | * CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.99721699 |
| 14 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.90271208 |
| 15 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.54706361 |
| 16 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.39579921 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.37915148 |
| 18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.30847387 |
| 19 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.28313702 |
| 20 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.21981650 |
| 21 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.18223603 |
| 22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.12442770 |
| 23 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.01807604 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.99984716 |
| 25 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.94305277 |
| 26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.93748795 |
| 27 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.93116827 |
| 28 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.85805818 |
| 29 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.85329881 |
| 30 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.84020026 |
| 31 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.83388373 |
| 32 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.74475556 |
| 33 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.69932787 |
| 34 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.66325804 |
| 35 | VDR_22108803_ChIP-Seq_LS180_Human | 1.65456655 |
| 36 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.58781471 |
| 37 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.52381063 |
| 38 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.52282993 |
| 39 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.47090797 |
| 40 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.44354630 |
| 41 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.43945812 |
| 42 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.39971772 |
| 43 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.39524155 |
| 44 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.28418161 |
| 45 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.26595024 |
| 46 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.25241529 |
| 47 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.24609081 |
| 48 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.23484455 |
| 49 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.22983721 |
| 50 | EWS_26573619_Chip-Seq_HEK293_Human | 1.22876139 |
| 51 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.22355375 |
| 52 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.22202346 |
| 53 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.22183568 |
| 54 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.22161321 |
| 55 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.19841602 |
| 56 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.19159661 |
| 57 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.18225247 |
| 58 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.14190238 |
| 59 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.12830950 |
| 60 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.12614818 |
| 61 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.12554371 |
| 62 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.11806626 |
| 63 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.09919986 |
| 64 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.09141473 |
| 65 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.08114657 |
| 66 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.07808139 |
| 67 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06958988 |
| 68 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.06664099 |
| 69 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.05488986 |
| 70 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.03320383 |
| 71 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.03219396 |
| 72 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.02286579 |
| 73 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.02078730 |
| 74 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.01798149 |
| 75 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.99455900 |
| 76 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.98737201 |
| 77 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.97777597 |
| 78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.97317000 |
| 79 | FUS_26573619_Chip-Seq_HEK293_Human | 0.96308731 |
| 80 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94809625 |
| 81 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.94140777 |
| 82 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.94072161 |
| 83 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.93180795 |
| 84 | NCOR_22424771_ChIP-Seq_293T_Human | 0.93114719 |
| 85 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.92780907 |
| 86 | AR_20517297_ChIP-Seq_VCAP_Human | 0.91420825 |
| 87 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.89774794 |
| 88 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88899656 |
| 89 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.88357737 |
| 90 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.88208266 |
| 91 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.86430416 |
| 92 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.86430416 |
| 93 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.85924192 |
| 94 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.85828862 |
| 95 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.85279700 |
| 96 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.84901105 |
| 97 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.84643058 |
| 98 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.84063291 |
| 99 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.83938257 |
| 100 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.82933851 |
| 101 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.82924158 |
| 102 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.82544556 |
| 103 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.81827926 |
| 104 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.81827926 |
| 105 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.81770382 |
| 106 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.80530442 |
| 107 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.80412969 |
| 108 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.79714942 |
| 109 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.79367661 |
| 110 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.79199876 |
| 111 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.78841633 |
| 112 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.78233511 |
| 113 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.78180007 |
| 114 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.78138461 |
| 115 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.78114896 |
| 116 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.78037551 |
| 117 | * SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.77150561 |
| 118 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.77100684 |
| 119 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.75141933 |
| 120 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.74739624 |
| 121 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.74739624 |
| 122 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.74739624 |
| 123 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.74042269 |
| 124 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.73265235 |
| 125 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.72316391 |
| 126 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.72297469 |
| 127 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.72112545 |
| 128 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.72006568 |
| 129 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.71879759 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 5.49301732 |
| 2 | MP0001529_abnormal_vocalization | 3.97197811 |
| 3 | MP0003136_yellow_coat_color | 3.46280552 |
| 4 | MP0003880_abnormal_central_pattern | 3.26841372 |
| 5 | MP0001905_abnormal_dopamine_level | 3.05276251 |
| 6 | MP0002837_dystrophic_cardiac_calcinosis | 2.70967051 |
| 7 | MP0003806_abnormal_nucleotide_metabolis | 2.63782208 |
| 8 | MP0006036_abnormal_mitochondrial_physio | 2.54050763 |
| 9 | MP0006276_abnormal_autonomic_nervous | 2.40404168 |
| 10 | MP0004142_abnormal_muscle_tone | 2.21056207 |
| 11 | MP0003186_abnormal_redox_activity | 2.09515741 |
| 12 | MP0005409_darkened_coat_color | 2.06562342 |
| 13 | MP0002638_abnormal_pupillary_reflex | 1.96896605 |
| 14 | MP0005171_absent_coat_pigmentation | 1.90596044 |
| 15 | MP0002736_abnormal_nociception_after | 1.88356332 |
| 16 | MP0004381_abnormal_hair_follicle | 1.85640502 |
| 17 | MP0008058_abnormal_DNA_repair | 1.83873661 |
| 18 | MP0000920_abnormal_myelination | 1.82279664 |
| 19 | MP0006035_abnormal_mitochondrial_morpho | 1.78976992 |
| 20 | MP0002938_white_spotting | 1.75878459 |
| 21 | MP0004133_heterotaxia | 1.74336129 |
| 22 | MP0005646_abnormal_pituitary_gland | 1.70350430 |
| 23 | MP0005451_abnormal_body_composition | 1.69438252 |
| 24 | MP0005499_abnormal_olfactory_system | 1.64668686 |
| 25 | MP0005394_taste/olfaction_phenotype | 1.64668686 |
| 26 | MP0002653_abnormal_ependyma_morphology | 1.61915852 |
| 27 | MP0001188_hyperpigmentation | 1.60341613 |
| 28 | MP0005408_hypopigmentation | 1.59983249 |
| 29 | MP0008877_abnormal_DNA_methylation | 1.56741712 |
| 30 | MP0005379_endocrine/exocrine_gland_phen | 1.54501277 |
| 31 | MP0006072_abnormal_retinal_apoptosis | 1.53680561 |
| 32 | MP0000372_irregular_coat_pigmentation | 1.52948111 |
| 33 | MP0003011_delayed_dark_adaptation | 1.51756571 |
| 34 | MP0001727_abnormal_embryo_implantation | 1.51208169 |
| 35 | MP0003787_abnormal_imprinting | 1.48998428 |
| 36 | MP0002163_abnormal_gland_morphology | 1.48254730 |
| 37 | MP0010030_abnormal_orbit_morphology | 1.47272805 |
| 38 | MP0006292_abnormal_olfactory_placode | 1.46916630 |
| 39 | MP0002160_abnormal_reproductive_system | 1.43516588 |
| 40 | MP0001968_abnormal_touch/_nociception | 1.43163318 |
| 41 | MP0002272_abnormal_nervous_system | 1.41486769 |
| 42 | MP0005423_abnormal_somatic_nervous | 1.36728847 |
| 43 | MP0002822_catalepsy | 1.36198922 |
| 44 | MP0003718_maternal_effect | 1.35146298 |
| 45 | MP0008875_abnormal_xenobiotic_pharmacok | 1.34051907 |
| 46 | MP0001986_abnormal_taste_sensitivity | 1.29137898 |
| 47 | MP0001485_abnormal_pinna_reflex | 1.26680373 |
| 48 | MP0004145_abnormal_muscle_electrophysio | 1.25673097 |
| 49 | MP0005410_abnormal_fertilization | 1.24435978 |
| 50 | MP0002102_abnormal_ear_morphology | 1.23856166 |
| 51 | MP0005389_reproductive_system_phenotype | 1.23533972 |
| 52 | MP0003123_paternal_imprinting | 1.23213158 |
| 53 | MP0002734_abnormal_mechanical_nocicepti | 1.21473374 |
| 54 | MP0003122_maternal_imprinting | 1.19551113 |
| 55 | MP0004742_abnormal_vestibular_system | 1.18702133 |
| 56 | MP0002234_abnormal_pharynx_morphology | 1.18655699 |
| 57 | MP0004270_analgesia | 1.18514110 |
| 58 | MP0005332_abnormal_amino_acid | 1.17762575 |
| 59 | MP0001440_abnormal_grooming_behavior | 1.17752749 |
| 60 | MP0004043_abnormal_pH_regulation | 1.16753787 |
| 61 | MP0000749_muscle_degeneration | 1.15993985 |
| 62 | MP0010386_abnormal_urinary_bladder | 1.15885471 |
| 63 | MP0003121_genomic_imprinting | 1.15847164 |
| 64 | MP0000751_myopathy | 1.13087234 |
| 65 | MP0003137_abnormal_impulse_conducting | 1.12448496 |
| 66 | MP0003786_premature_aging | 1.11835998 |
| 67 | MP0008872_abnormal_physiological_respon | 1.11336318 |
| 68 | MP0008932_abnormal_embryonic_tissue | 1.09910516 |
| 69 | MP0003646_muscle_fatigue | 1.08739607 |
| 70 | MP0004147_increased_porphyrin_level | 1.08207221 |
| 71 | MP0003950_abnormal_plasma_membrane | 1.07764998 |
| 72 | MP0002132_abnormal_respiratory_system | 1.07335063 |
| 73 | MP0002735_abnormal_chemical_nociception | 1.06129721 |
| 74 | MP0001293_anophthalmia | 1.06125841 |
| 75 | MP0001970_abnormal_pain_threshold | 1.06008622 |
| 76 | MP0005084_abnormal_gallbladder_morpholo | 1.05970160 |
| 77 | MP0002751_abnormal_autonomic_nervous | 1.04998780 |
| 78 | MP0000462_abnormal_digestive_system | 1.04973922 |
| 79 | MP0001919_abnormal_reproductive_system | 1.02842204 |
| 80 | MP0002277_abnormal_respiratory_mucosa | 1.02822121 |
| 81 | MP0002557_abnormal_social/conspecific_i | 1.01645064 |
| 82 | MP0003315_abnormal_perineum_morphology | 1.00406471 |
| 83 | MP0001984_abnormal_olfaction | 0.99786335 |
| 84 | MP0002095_abnormal_skin_pigmentation | 0.98927093 |
| 85 | MP0002876_abnormal_thyroid_physiology | 0.97637309 |
| 86 | MP0004215_abnormal_myocardial_fiber | 0.97029142 |
| 87 | MP0002332_abnormal_exercise_endurance | 0.96888074 |
| 88 | MP0004036_abnormal_muscle_relaxation | 0.96422946 |
| 89 | MP0005551_abnormal_eye_electrophysiolog | 0.95870808 |
| 90 | MP0000026_abnormal_inner_ear | 0.95831446 |
| 91 | MP0002064_seizures | 0.95610058 |
| 92 | MP0008789_abnormal_olfactory_epithelium | 0.93742596 |
| 93 | MP0002752_abnormal_somatic_nervous | 0.92031765 |
| 94 | MP0000778_abnormal_nervous_system | 0.91904881 |
| 95 | MP0000566_synostosis | 0.91854239 |
| 96 | MP0005253_abnormal_eye_physiology | 0.91429414 |
| 97 | MP0002210_abnormal_sex_determination | 0.90864050 |
| 98 | MP0002733_abnormal_thermal_nociception | 0.90856209 |
| 99 | MP0005645_abnormal_hypothalamus_physiol | 0.88155575 |
| 100 | MP0000762_abnormal_tongue_morphology | 0.87615492 |
| 101 | MP0009697_abnormal_copulation | 0.86568873 |
| 102 | MP0005195_abnormal_posterior_eye | 0.86163310 |
| 103 | MP0001764_abnormal_homeostasis | 0.86091633 |
| 104 | MP0004885_abnormal_endolymph | 0.85997157 |
| 105 | MP0005330_cardiomyopathy | 0.85881602 |
| 106 | MP0005266_abnormal_metabolism | 0.85815205 |
| 107 | MP0000538_abnormal_urinary_bladder | 0.85094893 |
| 108 | MP0003693_abnormal_embryo_hatching | 0.85050108 |
| 109 | MP0009745_abnormal_behavioral_response | 0.83914299 |
| 110 | MP0002184_abnormal_innervation | 0.83210407 |
| 111 | MP0005636_abnormal_mineral_homeostasis | 0.83099091 |
| 112 | MP0008995_early_reproductive_senescence | 0.82764151 |
| 113 | MP0000750_abnormal_muscle_regeneration | 0.81459663 |
| 114 | MP0001486_abnormal_startle_reflex | 0.80992317 |
| 115 | MP0005386_behavior/neurological_phenoty | 0.79374743 |
| 116 | MP0004924_abnormal_behavior | 0.79374743 |
| 117 | MP0001661_extended_life_span | 0.79293957 |
| 118 | MP0002229_neurodegeneration | 0.79040094 |
| 119 | MP0003195_calcinosis | 0.77910041 |
| 120 | MP0000631_abnormal_neuroendocrine_gland | 0.77809864 |
| 121 | MP0000049_abnormal_middle_ear | 0.76203795 |
| 122 | MP0002572_abnormal_emotion/affect_behav | 0.75266280 |
| 123 | MP0001963_abnormal_hearing_physiology | 0.74732478 |
| 124 | MP0005075_abnormal_melanosome_morpholog | 0.74662403 |
| 125 | MP0001664_abnormal_digestion | 0.73833255 |
| 126 | MP0005376_homeostasis/metabolism_phenot | 0.72684204 |
| 127 | MP0000653_abnormal_sex_gland | 0.72280656 |
| 128 | MP0002067_abnormal_sensory_capabilities | 0.72089027 |
| 129 | MP0009046_muscle_twitch | 0.71289319 |
| 130 | MP0010094_abnormal_chromosome_stability | 0.71027955 |
| 131 | MP0003634_abnormal_glial_cell | 0.70765064 |
| 132 | MP0003938_abnormal_ear_development | 0.70351836 |
| 133 | MP0005083_abnormal_biliary_tract | 0.70173672 |
| 134 | MP0003283_abnormal_digestive_organ | 0.69836021 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 7.23530249 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 6.48606193 |
| 3 | Mitochondrial inheritance (HP:0001427) | 6.35809580 |
| 4 | Acute encephalopathy (HP:0006846) | 6.01852802 |
| 5 | Progressive macrocephaly (HP:0004481) | 5.93151408 |
| 6 | Hepatocellular necrosis (HP:0001404) | 5.38100414 |
| 7 | Increased CSF lactate (HP:0002490) | 5.37478898 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 5.34016538 |
| 9 | Lipid accumulation in hepatocytes (HP:0006561) | 4.86736871 |
| 10 | Hepatic necrosis (HP:0002605) | 4.85515883 |
| 11 | Renal Fanconi syndrome (HP:0001994) | 4.82423097 |
| 12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.39941632 |
| 13 | Cerebral edema (HP:0002181) | 4.39344738 |
| 14 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.19939433 |
| 15 | 3-Methylglutaconic aciduria (HP:0003535) | 4.15651217 |
| 16 | Increased intramyocellular lipid droplets (HP:0012240) | 4.08847891 |
| 17 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 4.00895390 |
| 18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.96583156 |
| 19 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.96583156 |
| 20 | Leukodystrophy (HP:0002415) | 3.87582362 |
| 21 | Exercise intolerance (HP:0003546) | 3.83511042 |
| 22 | Respiratory failure (HP:0002878) | 3.78375352 |
| 23 | Optic disc pallor (HP:0000543) | 3.74162198 |
| 24 | Abnormal number of erythroid precursors (HP:0012131) | 3.69537372 |
| 25 | Abnormality of glycolysis (HP:0004366) | 3.68968986 |
| 26 | Increased serum pyruvate (HP:0003542) | 3.68968986 |
| 27 | Lactic acidosis (HP:0003128) | 3.61170124 |
| 28 | Increased muscle lipid content (HP:0009058) | 3.56682930 |
| 29 | Exertional dyspnea (HP:0002875) | 3.56571944 |
| 30 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.46764172 |
| 31 | Increased serum lactate (HP:0002151) | 3.38106690 |
| 32 | Parakeratosis (HP:0001036) | 3.28110032 |
| 33 | Reticulocytopenia (HP:0001896) | 3.25778822 |
| 34 | Abnormality of renal resorption (HP:0011038) | 3.19472756 |
| 35 | Macrocytic anemia (HP:0001972) | 3.10969365 |
| 36 | Pancreatic fibrosis (HP:0100732) | 2.99407823 |
| 37 | Pancreatic cysts (HP:0001737) | 2.95756371 |
| 38 | Respiratory difficulties (HP:0002880) | 2.93579882 |
| 39 | Molar tooth sign on MRI (HP:0002419) | 2.90003552 |
| 40 | Abnormality of midbrain morphology (HP:0002418) | 2.90003552 |
| 41 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.89908528 |
| 42 | True hermaphroditism (HP:0010459) | 2.71947166 |
| 43 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.50037011 |
| 44 | Abnormality of urine glucose concentration (HP:0011016) | 2.46612643 |
| 45 | Glycosuria (HP:0003076) | 2.46612643 |
| 46 | Sensory axonal neuropathy (HP:0003390) | 2.46138633 |
| 47 | Pallor (HP:0000980) | 2.45741242 |
| 48 | Nephronophthisis (HP:0000090) | 2.44826516 |
| 49 | Hyperphosphaturia (HP:0003109) | 2.42752252 |
| 50 | Lethargy (HP:0001254) | 2.37420467 |
| 51 | CNS demyelination (HP:0007305) | 2.37124920 |
| 52 | Hyperglycinemia (HP:0002154) | 2.33951422 |
| 53 | X-linked dominant inheritance (HP:0001423) | 2.32940965 |
| 54 | Neuroendocrine neoplasm (HP:0100634) | 2.32569734 |
| 55 | Cerebral hypomyelination (HP:0006808) | 2.29431884 |
| 56 | Sclerocornea (HP:0000647) | 2.22841951 |
| 57 | Congenital stationary night blindness (HP:0007642) | 2.21160865 |
| 58 | Pheochromocytoma (HP:0002666) | 2.18316009 |
| 59 | Microvesicular hepatic steatosis (HP:0001414) | 2.15130111 |
| 60 | Abnormal hemoglobin (HP:0011902) | 2.11865906 |
| 61 | Abnormal urine phosphate concentration (HP:0012599) | 2.11439218 |
| 62 | Emotional lability (HP:0000712) | 2.06201399 |
| 63 | Renal tubular dysfunction (HP:0000124) | 2.05572410 |
| 64 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.05404654 |
| 65 | Abnormality of placental membranes (HP:0011409) | 2.04491341 |
| 66 | Amniotic constriction ring (HP:0009775) | 2.04491341 |
| 67 | Concave nail (HP:0001598) | 1.97790410 |
| 68 | Type II lissencephaly (HP:0007260) | 1.96312995 |
| 69 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.95473082 |
| 70 | Congenital, generalized hypertrichosis (HP:0004540) | 1.94159637 |
| 71 | Septo-optic dysplasia (HP:0100842) | 1.93628387 |
| 72 | Abnormality of the renal cortex (HP:0011035) | 1.93137199 |
| 73 | Nephrogenic diabetes insipidus (HP:0009806) | 1.92749818 |
| 74 | Hypothermia (HP:0002045) | 1.92011711 |
| 75 | Abnormality of the renal medulla (HP:0100957) | 1.91557691 |
| 76 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.86920584 |
| 77 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.86920584 |
| 78 | Type 2 muscle fiber atrophy (HP:0003554) | 1.86666890 |
| 79 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.85583550 |
| 80 | Abnormality of the labia minora (HP:0012880) | 1.85575847 |
| 81 | Blindness (HP:0000618) | 1.83372534 |
| 82 | Abnormality of the axillary hair (HP:0100134) | 1.82308500 |
| 83 | Abnormality of secondary sexual hair (HP:0009888) | 1.82308500 |
| 84 | Aplastic anemia (HP:0001915) | 1.82043820 |
| 85 | Absent thumb (HP:0009777) | 1.81959635 |
| 86 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.81764039 |
| 87 | Abnormality of alanine metabolism (HP:0010916) | 1.81764039 |
| 88 | Hyperalaninemia (HP:0003348) | 1.81764039 |
| 89 | Abnormal pupillary function (HP:0007686) | 1.80811818 |
| 90 | Type I transferrin isoform profile (HP:0003642) | 1.80324280 |
| 91 | Methylmalonic aciduria (HP:0012120) | 1.80206565 |
| 92 | Abnormal protein glycosylation (HP:0012346) | 1.78816793 |
| 93 | Abnormal glycosylation (HP:0012345) | 1.78816793 |
| 94 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.78816793 |
| 95 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.78816793 |
| 96 | Hypoplasia of the pons (HP:0012110) | 1.78618677 |
| 97 | Abnormal ciliary motility (HP:0012262) | 1.77235345 |
| 98 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.76978750 |
| 99 | Retinal dysplasia (HP:0007973) | 1.76823747 |
| 100 | Hyperglycinuria (HP:0003108) | 1.76451551 |
| 101 | Pendular nystagmus (HP:0012043) | 1.75577231 |
| 102 | Medial flaring of the eyebrow (HP:0010747) | 1.74382851 |
| 103 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.74178099 |
| 104 | Dicarboxylic aciduria (HP:0003215) | 1.74178099 |
| 105 | Abnormality of the pons (HP:0007361) | 1.71343904 |
| 106 | Vomiting (HP:0002013) | 1.70037612 |
| 107 | Male pseudohermaphroditism (HP:0000037) | 1.70000067 |
| 108 | Anencephaly (HP:0002323) | 1.69662590 |
| 109 | Renal cortical cysts (HP:0000803) | 1.68825824 |
| 110 | Hypoplasia of the uterus (HP:0000013) | 1.68406917 |
| 111 | Muscle fiber atrophy (HP:0100295) | 1.66974676 |
| 112 | Colon cancer (HP:0003003) | 1.66734062 |
| 113 | Limb dystonia (HP:0002451) | 1.65997651 |
| 114 | Cystic liver disease (HP:0006706) | 1.64860785 |
| 115 | Abnormality of glycine metabolism (HP:0010895) | 1.64752082 |
| 116 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.64752082 |
| 117 | Abnormality of serum amino acid levels (HP:0003112) | 1.64098771 |
| 118 | Stenosis of the external auditory canal (HP:0000402) | 1.63114138 |
| 119 | Methylmalonic acidemia (HP:0002912) | 1.62491586 |
| 120 | Calf muscle hypertrophy (HP:0008981) | 1.62299964 |
| 121 | Pancytopenia (HP:0001876) | 1.61696360 |
| 122 | Partial duplication of thumb phalanx (HP:0009944) | 1.61376526 |
| 123 | Patchy hypopigmentation of hair (HP:0011365) | 1.59490841 |
| 124 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.58598721 |
| 125 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.58598721 |
| 126 | Cerebral hemorrhage (HP:0001342) | 1.57608034 |
| 127 | Palpitations (HP:0001962) | 1.56308936 |
| 128 | Myokymia (HP:0002411) | 1.55935970 |
| 129 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.55773416 |
| 130 | Progressive external ophthalmoplegia (HP:0000590) | 1.55653859 |
| 131 | Hypoplastic left heart (HP:0004383) | 1.52732280 |
| 132 | CNS hypomyelination (HP:0003429) | 1.49878859 |
| 133 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.46515910 |
| 134 | Generalized aminoaciduria (HP:0002909) | 1.42953074 |
| 135 | Spastic paraparesis (HP:0002313) | 1.41701759 |
| 136 | Gliosis (HP:0002171) | 1.41233782 |
| 137 | Absent/shortened dynein arms (HP:0200106) | 1.40496047 |
| 138 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.40496047 |
| 139 | Adrenal hypoplasia (HP:0000835) | 1.40424188 |
| 140 | Vaginal atresia (HP:0000148) | 1.36648521 |
| 141 | Gait imbalance (HP:0002141) | 1.36496583 |
| 142 | Poor suck (HP:0002033) | 1.35924504 |
| 143 | Congenital primary aphakia (HP:0007707) | 1.35425103 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.58364504 |
| 2 | STK16 | 4.09151272 |
| 3 | NME2 | 3.49165321 |
| 4 | STK39 | 3.22948899 |
| 5 | NME1 | 2.75611382 |
| 6 | PBK | 2.63066255 |
| 7 | MAP3K12 | 2.32366530 |
| 8 | MYLK | 2.30960101 |
| 9 | MAP4K2 | 2.30693446 |
| 10 | BUB1 | 2.30239164 |
| 11 | TLK1 | 2.29039043 |
| 12 | VRK1 | 2.14019130 |
| 13 | OXSR1 | 2.13281097 |
| 14 | MST4 | 2.13264150 |
| 15 | MUSK | 2.10028152 |
| 16 | NUAK1 | 2.09991705 |
| 17 | WNK4 | 2.06161785 |
| 18 | GRK7 | 1.98780882 |
| 19 | ARAF | 1.90733099 |
| 20 | NEK1 | 1.86281908 |
| 21 | CASK | 1.86181048 |
| 22 | BCKDK | 1.79659729 |
| 23 | FRK | 1.77987848 |
| 24 | LIMK1 | 1.73220613 |
| 25 | BCR | 1.72808946 |
| 26 | CDK19 | 1.65088532 |
| 27 | PNCK | 1.59817776 |
| 28 | TNIK | 1.59199775 |
| 29 | CDC7 | 1.58176187 |
| 30 | OBSCN | 1.56687244 |
| 31 | BMPR1B | 1.54989319 |
| 32 | PIM2 | 1.51580370 |
| 33 | MAPKAPK5 | 1.48203711 |
| 34 | DYRK2 | 1.46840798 |
| 35 | ADRBK2 | 1.39125577 |
| 36 | SRPK1 | 1.38265488 |
| 37 | CSNK1G3 | 1.32973527 |
| 38 | GRK5 | 1.21631218 |
| 39 | MAPK15 | 1.20769226 |
| 40 | TESK2 | 1.20529546 |
| 41 | INSRR | 1.20247892 |
| 42 | EIF2AK1 | 1.19023634 |
| 43 | UHMK1 | 1.18815638 |
| 44 | CAMK2B | 1.15321809 |
| 45 | EIF2AK3 | 1.13086660 |
| 46 | TAF1 | 1.11193498 |
| 47 | CAMK2D | 1.08879550 |
| 48 | PLK3 | 1.06642476 |
| 49 | WEE1 | 1.04450941 |
| 50 | MAP3K4 | 1.03684836 |
| 51 | PKN1 | 1.02184921 |
| 52 | BRAF | 1.02010090 |
| 53 | MAP2K7 | 0.97216797 |
| 54 | ABL2 | 0.96373933 |
| 55 | CCNB1 | 0.93862669 |
| 56 | MAP2K2 | 0.92541349 |
| 57 | CAMK2G | 0.88143277 |
| 58 | CSNK1G1 | 0.87715288 |
| 59 | PRKCG | 0.85637178 |
| 60 | ILK | 0.84758914 |
| 61 | KDR | 0.81203751 |
| 62 | PLK1 | 0.80379459 |
| 63 | IRAK2 | 0.80053854 |
| 64 | DAPK3 | 0.79685402 |
| 65 | TRIM28 | 0.79128491 |
| 66 | ROCK2 | 0.77369910 |
| 67 | PINK1 | 0.76449653 |
| 68 | ADRBK1 | 0.75673363 |
| 69 | WNK3 | 0.73454091 |
| 70 | RPS6KA5 | 0.73025629 |
| 71 | PLK2 | 0.71218458 |
| 72 | EPHA4 | 0.69387462 |
| 73 | AURKB | 0.68693436 |
| 74 | CAMK2A | 0.68638287 |
| 75 | PHKG2 | 0.68601135 |
| 76 | PHKG1 | 0.68601135 |
| 77 | AURKA | 0.68523536 |
| 78 | IRAK1 | 0.68225560 |
| 79 | CSNK1A1L | 0.65007500 |
| 80 | NEK6 | 0.64385831 |
| 81 | TESK1 | 0.64017953 |
| 82 | MAPK13 | 0.63483477 |
| 83 | BRSK2 | 0.63149044 |
| 84 | ZAK | 0.62461422 |
| 85 | MKNK1 | 0.62225809 |
| 86 | IRAK3 | 0.61978461 |
| 87 | CHEK2 | 0.61164750 |
| 88 | CDK8 | 0.59775255 |
| 89 | GRK1 | 0.59728161 |
| 90 | CSNK1G2 | 0.59096112 |
| 91 | CSNK2A1 | 0.57298470 |
| 92 | FGR | 0.56276646 |
| 93 | MET | 0.55128325 |
| 94 | PRKACA | 0.54532629 |
| 95 | TAOK3 | 0.53367121 |
| 96 | PASK | 0.53227942 |
| 97 | CSNK2A2 | 0.53021900 |
| 98 | BRSK1 | 0.52712793 |
| 99 | ATR | 0.51836958 |
| 100 | PLK4 | 0.51188632 |
| 101 | TIE1 | 0.50402267 |
| 102 | CSNK1A1 | 0.49370195 |
| 103 | PIK3CG | 0.48709073 |
| 104 | EPHA2 | 0.48011151 |
| 105 | PRKCE | 0.48005435 |
| 106 | IRAK4 | 0.47339211 |
| 107 | MAP3K11 | 0.46444994 |
| 108 | YES1 | 0.45855425 |
| 109 | BMPR2 | 0.45030215 |
| 110 | DAPK2 | 0.44269069 |
| 111 | PAK1 | 0.43842671 |
| 112 | DYRK3 | 0.43396513 |
| 113 | PRKCI | 0.42639819 |
| 114 | MARK1 | 0.42033448 |
| 115 | DAPK1 | 0.41709317 |
| 116 | PDK2 | 0.40552703 |
| 117 | CDK14 | 0.39853390 |
| 118 | PRKCQ | 0.39683123 |
| 119 | EIF2AK2 | 0.39254964 |
| 120 | MINK1 | 0.38899771 |
| 121 | MKNK2 | 0.36888458 |
| 122 | PIK3CA | 0.36724900 |
| 123 | LRRK2 | 0.36212232 |
| 124 | CSNK1E | 0.34758623 |
| 125 | PAK3 | 0.34174871 |
| 126 | PRKG2 | 0.33544806 |
| 127 | MAPK4 | 0.32769314 |
| 128 | CAMK1 | 0.32354749 |
| 129 | CDK11A | 0.31983059 |
| 130 | PRKG1 | 0.31296152 |
| 131 | PDK4 | 0.28793622 |
| 132 | PDK3 | 0.28793622 |
| 133 | CDK7 | 0.28499576 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Oxidative phosphorylation_Homo sapiens_hsa00190 | 6.10143574 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 5.17803263 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 4.98102974 |
| 4 | Alzheimers disease_Homo sapiens_hsa05010 | 3.87450944 |
| 5 | Huntingtons disease_Homo sapiens_hsa05016 | 3.72160959 |
| 6 | Proteasome_Homo sapiens_hsa03050 | 3.62307231 |
| 7 | * Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 3.24881787 |
| 8 | Protein export_Homo sapiens_hsa03060 | 3.11190935 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.84619683 |
| 10 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.56377224 |
| 11 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.31001490 |
| 12 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.11391086 |
| 13 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.74690424 |
| 14 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.59354982 |
| 15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.50920154 |
| 16 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.48438835 |
| 17 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.39964689 |
| 18 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.38797116 |
| 19 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.37557840 |
| 20 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.33663511 |
| 21 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.10857939 |
| 22 | Spliceosome_Homo sapiens_hsa03040 | 1.07283692 |
| 23 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.01278899 |
| 24 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.00883682 |
| 25 | Homologous recombination_Homo sapiens_hsa03440 | 0.99320585 |
| 26 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.97463493 |
| 27 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.95388397 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.94863357 |
| 29 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.94524178 |
| 30 | Mismatch repair_Homo sapiens_hsa03430 | 0.93664440 |
| 31 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.92421790 |
| 32 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.92045926 |
| 33 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.91785391 |
| 34 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.90855210 |
| 35 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.89500007 |
| 36 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.87977898 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 0.87741216 |
| 38 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.87238922 |
| 39 | DNA replication_Homo sapiens_hsa03030 | 0.86866424 |
| 40 | Basal transcription factors_Homo sapiens_hsa03022 | 0.86470742 |
| 41 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.85808945 |
| 42 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.84563890 |
| 43 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84547038 |
| 44 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.83652980 |
| 45 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.83219068 |
| 46 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.78893217 |
| 47 | Histidine metabolism_Homo sapiens_hsa00340 | 0.78378821 |
| 48 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.78234989 |
| 49 | Sulfur relay system_Homo sapiens_hsa04122 | 0.77178814 |
| 50 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.74411760 |
| 51 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.73810186 |
| 52 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.71881977 |
| 53 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.70332659 |
| 54 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.69004097 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.67741475 |
| 56 | Peroxisome_Homo sapiens_hsa04146 | 0.67574884 |
| 57 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.66950974 |
| 58 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.66883607 |
| 59 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.62853750 |
| 60 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.62566341 |
| 61 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.61881272 |
| 62 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.56228103 |
| 63 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.55493453 |
| 64 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.55447017 |
| 65 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.54167363 |
| 66 | Carbon metabolism_Homo sapiens_hsa01200 | 0.53746348 |
| 67 | RNA degradation_Homo sapiens_hsa03018 | 0.52415747 |
| 68 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.51765016 |
| 69 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.49331977 |
| 70 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.43701326 |
| 71 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.40403872 |
| 72 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.40174072 |
| 73 | Phototransduction_Homo sapiens_hsa04744 | 0.40070290 |
| 74 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.38618179 |
| 75 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.36687356 |
| 76 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.35490887 |
| 77 | Base excision repair_Homo sapiens_hsa03410 | 0.35376259 |
| 78 | Olfactory transduction_Homo sapiens_hsa04740 | 0.35307567 |
| 79 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.33892973 |
| 80 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.32236936 |
| 81 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.30587966 |
| 82 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.29845536 |
| 83 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.29716309 |
| 84 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.29352186 |
| 85 | Retinol metabolism_Homo sapiens_hsa00830 | 0.29263481 |
| 86 | Phagosome_Homo sapiens_hsa04145 | 0.28971695 |
| 87 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.28275722 |
| 88 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.28268660 |
| 89 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.27687033 |
| 90 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.27407573 |
| 91 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.27151360 |
| 92 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.26172734 |
| 93 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.25907547 |
| 94 | RNA transport_Homo sapiens_hsa03013 | 0.25789981 |
| 95 | GABAergic synapse_Homo sapiens_hsa04727 | 0.24743295 |
| 96 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.24545548 |
| 97 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.23613867 |
| 98 | Nicotine addiction_Homo sapiens_hsa05033 | 0.22956516 |
| 99 | Alcoholism_Homo sapiens_hsa05034 | 0.21179081 |
| 100 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.21032440 |
| 101 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.20970837 |
| 102 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.20632111 |
| 103 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.20586082 |
| 104 | Morphine addiction_Homo sapiens_hsa05032 | 0.19134726 |
| 105 | Asthma_Homo sapiens_hsa05310 | 0.17852576 |
| 106 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.16806042 |
| 107 | Taste transduction_Homo sapiens_hsa04742 | 0.15922805 |
| 108 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.15638229 |
| 109 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.14757981 |
| 110 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.14529249 |
| 111 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.13342864 |
| 112 | Allograft rejection_Homo sapiens_hsa05330 | 0.12155123 |
| 113 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.11010272 |
| 114 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.10521260 |
| 115 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.09476690 |
| 116 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.09097824 |
| 117 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.08054585 |
| 118 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.07979256 |

