NDUFA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.76534076
2energy coupled proton transport, down electrochemical gradient (GO:0015985)9.27579040
3ATP synthesis coupled proton transport (GO:0015986)9.27579040
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.40384756
5* respiratory electron transport chain (GO:0022904)7.91857134
6* electron transport chain (GO:0022900)7.71734842
7oxidative phosphorylation (GO:0006119)5.69574747
8ATP biosynthetic process (GO:0006754)5.48392973
9tricarboxylic acid cycle (GO:0006099)5.27722062
10protein complex biogenesis (GO:0070271)4.93415395
11inner mitochondrial membrane organization (GO:0007007)4.86817990
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.86267576
13NADH dehydrogenase complex assembly (GO:0010257)4.86267576
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.86267576
15purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.85135930
16purine nucleoside triphosphate biosynthetic process (GO:0009145)4.79848580
17hydrogen ion transmembrane transport (GO:1902600)4.77157236
18chaperone-mediated protein transport (GO:0072321)4.67393114
19mitochondrial respiratory chain complex assembly (GO:0033108)4.57628912
20NADH metabolic process (GO:0006734)4.43617074
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.37368474
22ribonucleoside triphosphate biosynthetic process (GO:0009201)4.26427316
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.22115711
24proton transport (GO:0015992)4.17087862
25hydrogen transport (GO:0006818)4.10605718
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.09887487
27sarcomere organization (GO:0045214)4.07967562
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.04531246
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.02622223
30negative regulation of ligase activity (GO:0051352)4.02622223
31succinate metabolic process (GO:0006105)4.00560156
32regulation of oxidative phosphorylation (GO:0002082)3.99008861
33protein deneddylation (GO:0000338)3.99006774
34protein neddylation (GO:0045116)3.92376170
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.89710553
36aerobic respiration (GO:0009060)3.88160496
37establishment of integrated proviral latency (GO:0075713)3.88001867
38ubiquinone biosynthetic process (GO:0006744)3.76345629
39quinone biosynthetic process (GO:1901663)3.76345629
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.75669533
41regulation of acyl-CoA biosynthetic process (GO:0050812)3.72846111
42positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.70490471
43ribosomal small subunit assembly (GO:0000028)3.67842704
44nucleoside triphosphate biosynthetic process (GO:0009142)3.67614091
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.66568505
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.66568505
47signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.65055221
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.65055221
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.65055221
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.62762847
51regulation of coenzyme metabolic process (GO:0051196)3.61637818
52regulation of cofactor metabolic process (GO:0051193)3.61637818
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.60304829
54termination of RNA polymerase III transcription (GO:0006386)3.57218875
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.57218875
56negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.55869731
57mitochondrial transport (GO:0006839)3.55116451
58regulation of cellular respiration (GO:0043457)3.54900528
59signal transduction involved in DNA damage checkpoint (GO:0072422)3.54569079
60signal transduction involved in DNA integrity checkpoint (GO:0072401)3.54569079
61muscle filament sliding (GO:0030049)3.54416111
62actin-myosin filament sliding (GO:0033275)3.54416111
63viral transcription (GO:0019083)3.53599720
64heart process (GO:0003015)3.53268371
65heart contraction (GO:0060047)3.53268371
66signal transduction involved in cell cycle checkpoint (GO:0072395)3.51923015
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47854500
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.46710787
69cotranslational protein targeting to membrane (GO:0006613)3.46434459
70ubiquinone metabolic process (GO:0006743)3.45657256
71translational termination (GO:0006415)3.45136915
72positive regulation of ligase activity (GO:0051351)3.43548248
73protein targeting to ER (GO:0045047)3.41420372
74purine nucleoside monophosphate biosynthetic process (GO:0009127)3.40964499
75purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.40964499
76regulation of mitochondrial translation (GO:0070129)3.40326671
77establishment of viral latency (GO:0019043)3.35959724
78translation (GO:0006412)3.33672856
79DNA damage response, detection of DNA damage (GO:0042769)3.31941442
80respiratory chain complex IV assembly (GO:0008535)3.30752323
81protein targeting to mitochondrion (GO:0006626)3.30121444
82protein localization to endoplasmic reticulum (GO:0070972)3.29669134
83establishment of protein localization to endoplasmic reticulum (GO:0072599)3.28584398
84regulation of relaxation of muscle (GO:1901077)3.26861931
85ATP hydrolysis coupled proton transport (GO:0015991)3.26606077
86energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.26606077
87rRNA modification (GO:0000154)3.25966492
88ribosomal large subunit biogenesis (GO:0042273)3.25675089
89regulation of ubiquitin-protein transferase activity (GO:0051438)3.24004284
90establishment of protein localization to mitochondrion (GO:0072655)3.23212419
91protein maturation by protein folding (GO:0022417)3.22699704
92cytochrome complex assembly (GO:0017004)3.21771571
93maturation of SSU-rRNA (GO:0030490)3.20597294
94regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.20179405
95* generation of precursor metabolites and energy (GO:0006091)3.18292049
96oxaloacetate metabolic process (GO:0006107)3.16769003
97pseudouridine synthesis (GO:0001522)3.13985550
98translational elongation (GO:0006414)3.13849080
99proteasome assembly (GO:0043248)3.12926080
100negative regulation of protein localization to cell surface (GO:2000009)3.12425365
101regulation of ligase activity (GO:0051340)3.11449646
102spliceosomal snRNP assembly (GO:0000387)3.11333898
103cardiac myofibril assembly (GO:0055003)3.10611156
104RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09795499
105tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09795499
106regulation of cellular amine metabolic process (GO:0033238)3.09286917
107cellular ketone body metabolic process (GO:0046950)3.08448874
108cellular respiration (GO:0045333)3.06733693
109protein localization to mitochondrion (GO:0070585)3.06587511
110regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05306195
111regulation of cell communication by electrical coupling (GO:0010649)3.04218684
112cardiac muscle contraction (GO:0060048)3.03677272
113negative regulation of potassium ion transmembrane transport (GO:1901380)3.02650720
114cellular component biogenesis (GO:0044085)2.96539398
115negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95448853
116purine ribonucleoside biosynthetic process (GO:0046129)2.95190730
117purine nucleoside biosynthetic process (GO:0042451)2.95190730
118chromatin remodeling at centromere (GO:0031055)2.94895355
119CENP-A containing nucleosome assembly (GO:0034080)2.94855328
120translational initiation (GO:0006413)2.94047948
121sequestering of actin monomers (GO:0042989)2.93591340
122myofibril assembly (GO:0030239)2.92338872
123regulation of cellular amino acid metabolic process (GO:0006521)2.87578814
124viral life cycle (GO:0019058)2.86524348
125regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.85652608
126pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85313651
127branched-chain amino acid catabolic process (GO:0009083)2.84354600
128ribosomal small subunit biogenesis (GO:0042274)2.81459383
129actin-mediated cell contraction (GO:0070252)2.81366581
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79979856
131guanosine-containing compound biosynthetic process (GO:1901070)2.79426155
132nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79287206
133cardiac muscle tissue morphogenesis (GO:0055008)2.78968953
134regulation of actin filament-based movement (GO:1903115)2.78787626
135regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.78382816
136cellular protein complex disassembly (GO:0043624)2.78321558
137positive regulation of cell cycle arrest (GO:0071158)2.78125771
138heme biosynthetic process (GO:0006783)2.75496006
139protoporphyrinogen IX biosynthetic process (GO:0006782)2.73551141
140substantia nigra development (GO:0021762)2.71284772
141cullin deneddylation (GO:0010388)2.70777173
142intracellular protein transmembrane import (GO:0044743)2.70572558
143ribonucleoside monophosphate biosynthetic process (GO:0009156)2.69903489
144dopamine transport (GO:0015872)2.67637465
145ketone body metabolic process (GO:1902224)2.67217202
146aldehyde catabolic process (GO:0046185)2.66179676
147ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.65648951
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65008418
149GTP biosynthetic process (GO:0006183)2.63736280
150quinone metabolic process (GO:1901661)2.60784240
151positive regulation of mitochondrial fission (GO:0090141)2.59369849
152regulation of sulfur metabolic process (GO:0042762)2.58735479
153negative regulation of response to food (GO:0032096)2.57943954
154negative regulation of appetite (GO:0032099)2.57943954
155aspartate family amino acid catabolic process (GO:0009068)2.56963001
156regulation of skeletal muscle contraction (GO:0014819)2.56825798
157protein-cofactor linkage (GO:0018065)2.56334701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.73407115
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.08622666
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.94809382
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.88274237
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.31761995
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17292526
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.12758892
8EZH2_22144423_ChIP-Seq_EOC_Human2.97989705
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.89570594
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83209701
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.73656486
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66579853
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.65719600
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63014518
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.62170882
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.58835400
17E2F7_22180533_ChIP-Seq_HELA_Human2.57020975
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42938705
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40683127
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.34097819
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22368549
22ELK1_19687146_ChIP-ChIP_HELA_Human2.15389215
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14504677
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11744289
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.08146777
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.07359474
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04194043
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02786852
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.96259156
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93945893
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93486829
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83326000
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71066932
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69115333
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67810131
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63153562
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57242250
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56450612
39* YY1_21170310_ChIP-Seq_MESCs_Mouse1.55941070
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55147641
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51268096
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49318584
43DCP1A_22483619_ChIP-Seq_HELA_Human1.49265149
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48812136
45VDR_22108803_ChIP-Seq_LS180_Human1.48448999
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45391166
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43983049
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42303343
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.41816592
50ZNF263_19887448_ChIP-Seq_K562_Human1.39601654
51TAF15_26573619_Chip-Seq_HEK293_Human1.39512243
52CTCF_18555785_ChIP-Seq_MESCs_Mouse1.39491557
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39251648
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39021439
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38719704
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38645320
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35839348
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.35322459
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32765643
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31364068
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28181241
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27315900
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26835772
64CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.26704549
65AR_21909140_ChIP-Seq_LNCAP_Human1.22392093
66VDR_23849224_ChIP-Seq_CD4+_Human1.20650837
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20257450
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17702488
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15856973
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.15473575
71* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14687757
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14013932
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13915600
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13067737
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12062363
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.10632975
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09852792
78KDM5A_27292631_Chip-Seq_BREAST_Human1.06558260
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06486679
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06033753
81GBX2_23144817_ChIP-Seq_PC3_Human1.05377530
82XRN2_22483619_ChIP-Seq_HELA_Human1.03808250
83MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01734725
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00609469
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00234165
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99539015
87HTT_18923047_ChIP-ChIP_STHdh_Human0.98442204
88FOXM1_23109430_ChIP-Seq_U2OS_Human0.98355717
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96522739
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95883045
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95459824
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.95339372
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94528281
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94058469
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94041567
96JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93817464
97GABP_19822575_ChIP-Seq_HepG2_Human0.93559843
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93259985
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92605090
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92538529
101REST_18959480_ChIP-ChIP_MESCs_Mouse0.92228723
102ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91570672
103E2F1_21310950_ChIP-Seq_MCF-7_Human0.90729924
104FOXP3_21729870_ChIP-Seq_TREG_Human0.90710101
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90552736
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.90514482
107CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89118934
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88548305
109MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88134481
110MYC_18940864_ChIP-ChIP_HL60_Human0.87871052
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.87738417
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87545612
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87520423
114FOXP1_21924763_ChIP-Seq_HESCs_Human0.87312959
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87017609
116SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86754469
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86699146
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86664625
119TTF2_22483619_ChIP-Seq_HELA_Human0.86662238
120EOMES_21245162_ChIP-Seq_HESCs_Human0.85801907
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85703683
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85355351
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85183582
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85054063
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84655338
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84464536
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.84235030
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84085561
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83831401
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83140432
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82687174
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82611613
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.82278951
134EED_16625203_ChIP-ChIP_MESCs_Mouse0.82183437
135STAT1_20625510_ChIP-Seq_HELA_Human0.82017543
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81578389
137GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80537295
138RXR_22158963_ChIP-Seq_LIVER_Mouse0.80146174
139MYC_19030024_ChIP-ChIP_MESCs_Mouse0.79704032
140NANOG_20526341_ChIP-Seq_ESCs_Human0.79189928
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78674294
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.77987802
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77885463
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77488747
145NCOR_22424771_ChIP-Seq_293T_Human0.76660196
146PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76024157
147EZH2_18974828_ChIP-Seq_MESCs_Mouse0.75975886
148RNF2_18974828_ChIP-Seq_MESCs_Mouse0.75975886
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75559273
150MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74398062
151NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73027031
152PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.69197082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.92689239
2MP0003646_muscle_fatigue4.32373160
3MP0000751_myopathy3.72788938
4MP0004084_abnormal_cardiac_muscle3.44263618
5MP0004215_abnormal_myocardial_fiber3.29007659
6MP0000749_muscle_degeneration3.23504912
7MP0006036_abnormal_mitochondrial_physio3.13678470
8MP0004036_abnormal_muscle_relaxation3.10565736
9MP0005330_cardiomyopathy2.78387921
10MP0008058_abnormal_DNA_repair2.75302387
11MP0001529_abnormal_vocalization2.66370939
12MP0003806_abnormal_nucleotide_metabolis2.47667839
13MP0009379_abnormal_foot_pigmentation2.32235255
14MP0003137_abnormal_impulse_conducting2.20552656
15MP0003880_abnormal_central_pattern2.18800273
16MP0002972_abnormal_cardiac_muscle2.17634687
17MP0006035_abnormal_mitochondrial_morpho2.14765318
18MP0004957_abnormal_blastocyst_morpholog2.11756318
19MP0003693_abnormal_embryo_hatching2.03844326
20MP0005620_abnormal_muscle_contractility1.96672513
21MP0010094_abnormal_chromosome_stability1.95637003
22MP0004484_altered_response_of1.92318635
23MP0001905_abnormal_dopamine_level1.90951719
24MP0006276_abnormal_autonomic_nervous1.89204105
25MP0004145_abnormal_muscle_electrophysio1.87792817
26MP0008932_abnormal_embryonic_tissue1.86577369
27MP0002332_abnormal_exercise_endurance1.85713687
28MP0003718_maternal_effect1.83234015
29MP0008775_abnormal_heart_ventricle1.81144279
30MP0000750_abnormal_muscle_regeneration1.78983467
31MP0010030_abnormal_orbit_morphology1.78408350
32MP0002106_abnormal_muscle_physiology1.72847429
33MP0003786_premature_aging1.71768737
34MP0008789_abnormal_olfactory_epithelium1.71227364
35MP0001544_abnormal_cardiovascular_syste1.68929154
36MP0005385_cardiovascular_system_phenoty1.68929154
37MP0004087_abnormal_muscle_fiber1.66039305
38MP0004085_abnormal_heartbeat1.63603138
39MP0002822_catalepsy1.62705198
40MP0002938_white_spotting1.60557746
41MP0003111_abnormal_nucleus_morphology1.56444307
42MP0004142_abnormal_muscle_tone1.55810875
43MP0006292_abnormal_olfactory_placode1.55680558
44MP0006138_congestive_heart_failure1.55679411
45MP0003136_yellow_coat_color1.54365354
46MP0002102_abnormal_ear_morphology1.52533910
47MP0002736_abnormal_nociception_after1.51843729
48MP0003077_abnormal_cell_cycle1.49281552
49MP0000747_muscle_weakness1.47434256
50MP0005369_muscle_phenotype1.41377858
51MP0003195_calcinosis1.39611023
52MP0009046_muscle_twitch1.39427058
53MP0002269_muscular_atrophy1.39142181
54MP0003221_abnormal_cardiomyocyte_apopto1.38455040
55MP0003186_abnormal_redox_activity1.38273556
56MP0005670_abnormal_white_adipose1.37572850
57MP0000759_abnormal_skeletal_muscle1.35946800
58MP0009745_abnormal_behavioral_response1.35446897
59MP0002064_seizures1.35438122
60MP0003011_delayed_dark_adaptation1.35039052
61MP0002272_abnormal_nervous_system1.34777517
62MP0006072_abnormal_retinal_apoptosis1.33951253
63MP0001968_abnormal_touch/_nociception1.28564556
64MP0004147_increased_porphyrin_level1.28167342
65MP0005332_abnormal_amino_acid1.26001013
66MP0008875_abnormal_xenobiotic_pharmacok1.25989552
67MP0005451_abnormal_body_composition1.25942060
68MP0004130_abnormal_muscle_cell1.24907893
69MP0002234_abnormal_pharynx_morphology1.24082960
70MP0005266_abnormal_metabolism1.23938722
71MP0002735_abnormal_chemical_nociception1.20006672
72MP0000358_abnormal_cell_content/1.19606580
73MP0001440_abnormal_grooming_behavior1.19283606
74MP0004924_abnormal_behavior1.15059397
75MP0005386_behavior/neurological_phenoty1.15059397
76MP0005083_abnormal_biliary_tract1.15043624
77MP0005499_abnormal_olfactory_system1.14586419
78MP0005394_taste/olfaction_phenotype1.14586419
79MP0000230_abnormal_systemic_arterial1.13382131
80MP0003123_paternal_imprinting1.13138470
81MP0005085_abnormal_gallbladder_physiolo1.12842485
82MP0005535_abnormal_body_temperature1.12601151
83MP0004043_abnormal_pH_regulation1.12252843
84MP0008007_abnormal_cellular_replicative1.10175801
85MP0005360_urolithiasis1.08714721
86MP0008995_early_reproductive_senescence1.06450713
87MP0004510_myositis1.04462081
88MP0002139_abnormal_hepatobiliary_system1.03350373
89MP0002734_abnormal_mechanical_nocicepti1.03311915
90MP0003635_abnormal_synaptic_transmissio1.02629722
91MP0001984_abnormal_olfaction1.01390300
92MP0001970_abnormal_pain_threshold1.01313847
93MP0002572_abnormal_emotion/affect_behav1.00317288
94MP0003950_abnormal_plasma_membrane0.99755264
95MP0005584_abnormal_enzyme/coenzyme_acti0.99653251
96MP0002160_abnormal_reproductive_system0.98037214
97MP0005423_abnormal_somatic_nervous0.97255602
98MP0005165_increased_susceptibility_to0.97225080
99MP0002127_abnormal_cardiovascular_syste0.96628253
100MP0004270_analgesia0.95697051
101MP0009697_abnormal_copulation0.95427294
102MP0010630_abnormal_cardiac_muscle0.95390785
103MP0002090_abnormal_vision0.95019718
104MP0003567_abnormal_fetal_cardiomyocyte0.94240290
105MP0000343_altered_response_to0.92713223
106MP0003315_abnormal_perineum_morphology0.90977239
107MP0002067_abnormal_sensory_capabilities0.90893504
108MP0005253_abnormal_eye_physiology0.90260431
109MP0003329_amyloid_beta_deposits0.89573756
110MP0005408_hypopigmentation0.87970541
111MP0002876_abnormal_thyroid_physiology0.87885421
112MP0002733_abnormal_thermal_nociception0.87135933
113MP0002210_abnormal_sex_determination0.86298982
114MP0001485_abnormal_pinna_reflex0.84194801
115MP0005636_abnormal_mineral_homeostasis0.83703257
116MP0002063_abnormal_learning/memory/cond0.82438460
117MP0003656_abnormal_erythrocyte_physiolo0.81786061
118MP0003941_abnormal_skin_development0.81704390
119MP0003122_maternal_imprinting0.80768132
120MP0005376_homeostasis/metabolism_phenot0.80139495
121MP0008877_abnormal_DNA_methylation0.79337498
122MP0001986_abnormal_taste_sensitivity0.79322346
123MP0003828_pulmonary_edema0.78306936
124MP0001486_abnormal_startle_reflex0.76911324
125MP0002653_abnormal_ependyma_morphology0.76798511
126MP0001293_anophthalmia0.76271923
127MP0001727_abnormal_embryo_implantation0.76107541
128MP0004233_abnormal_muscle_weight0.75544193
129MP0003121_genomic_imprinting0.75113215
130MP0008872_abnormal_physiological_respon0.74672985
131MP0005551_abnormal_eye_electrophysiolog0.74594175
132MP0005084_abnormal_gallbladder_morpholo0.74565252
133MP0000049_abnormal_middle_ear0.74503114
134MP0000920_abnormal_myelination0.73277183
135MP0001764_abnormal_homeostasis0.71644613
136MP0001929_abnormal_gametogenesis0.70289474
137MP0004859_abnormal_synaptic_plasticity0.70049474
138MP0000013_abnormal_adipose_tissue0.69101116
139MP0005319_abnormal_enzyme/_coenzyme0.69028100
140MP0000372_irregular_coat_pigmentation0.68545659
141MP0002638_abnormal_pupillary_reflex0.68498419
142MP0001188_hyperpigmentation0.65569258
143MP0002095_abnormal_skin_pigmentation0.65051057
144MP0002066_abnormal_motor_capabilities/c0.64707609
145MP0003879_abnormal_hair_cell0.62362959

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.01767243
2Abnormal mitochondria in muscle tissue (HP:0008316)6.60172800
3Mitochondrial inheritance (HP:0001427)6.11018055
4Acute encephalopathy (HP:0006846)6.01597341
5Progressive macrocephaly (HP:0004481)5.83272434
6Hepatocellular necrosis (HP:0001404)5.77558775
7Hepatic necrosis (HP:0002605)5.51857134
8Increased CSF lactate (HP:0002490)5.37305677
9Cerebral edema (HP:0002181)4.83753621
10Abnormality of glycolysis (HP:0004366)4.23984488
11Increased serum pyruvate (HP:0003542)4.23984488
12Sudden death (HP:0001699)4.16966228
13Lactic acidosis (HP:0003128)4.16217634
14Increased hepatocellular lipid droplets (HP:0006565)4.12112540
15Lipid accumulation in hepatocytes (HP:0006561)4.05958402
16Increased intramyocellular lipid droplets (HP:0012240)4.05763690
17Exercise intolerance (HP:0003546)4.01922197
18Respiratory failure (HP:0002878)4.00128370
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.87255322
20Increased muscle lipid content (HP:0009058)3.87133215
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.77931878
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.77931878
23Calf muscle hypertrophy (HP:0008981)3.70002220
24Muscle hypertrophy of the lower extremities (HP:0008968)3.66066932
25Increased serum lactate (HP:0002151)3.55042242
26Renal Fanconi syndrome (HP:0001994)3.53219304
27Optic disc pallor (HP:0000543)3.46582136
28Leukodystrophy (HP:0002415)3.42042881
29Pheochromocytoma (HP:0002666)3.40004491
30Palpitations (HP:0001962)3.39162680
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.38013110
32Neuroendocrine neoplasm (HP:0100634)3.33977762
33Exercise-induced myalgia (HP:0003738)3.17623558
34Ventricular tachycardia (HP:0004756)3.08974875
35Myoglobinuria (HP:0002913)3.08915040
363-Methylglutaconic aciduria (HP:0003535)3.08539762
37Exercise-induced muscle cramps (HP:0003710)3.07903989
38Abnormal number of erythroid precursors (HP:0012131)2.93914630
39Lethargy (HP:0001254)2.78957998
40Muscle fiber splitting (HP:0003555)2.78398579
41Atrial fibrillation (HP:0005110)2.74912641
42Type I transferrin isoform profile (HP:0003642)2.74751507
43Rhabdomyolysis (HP:0003201)2.74706768
44Abnormality of the calf musculature (HP:0001430)2.73766762
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71525319
46Dicarboxylic aciduria (HP:0003215)2.71525319
47CNS demyelination (HP:0007305)2.66790042
48Myotonia (HP:0002486)2.63981321
49Lipoatrophy (HP:0100578)2.63792081
50Supraventricular tachycardia (HP:0004755)2.60542900
51Primary atrial arrhythmia (HP:0001692)2.57614320
52Exertional dyspnea (HP:0002875)2.56025973
53Macrocytic anemia (HP:0001972)2.55118483
54Ragged-red muscle fibers (HP:0003200)2.54167150
55Supraventricular arrhythmia (HP:0005115)2.52835353
56Respiratory difficulties (HP:0002880)2.52156793
57Conjunctival hamartoma (HP:0100780)2.51404587
58Dilated cardiomyopathy (HP:0001644)2.45212601
59Nemaline bodies (HP:0003798)2.44027563
60X-linked dominant inheritance (HP:0001423)2.42010784
61Glycosuria (HP:0003076)2.40607205
62Abnormality of urine glucose concentration (HP:0011016)2.40607205
63Abnormality of fatty-acid metabolism (HP:0004359)2.39800597
64Syncope (HP:0001279)2.36265793
65Emotional lability (HP:0000712)2.35590084
66Muscle fiber inclusion bodies (HP:0100299)2.32860797
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32501212
68Abnormality of alanine metabolism (HP:0010916)2.32501212
69Hyperalaninemia (HP:0003348)2.32501212
70Reticulocytopenia (HP:0001896)2.32112923
71Cerebral hypomyelination (HP:0006808)2.31816455
72Vomiting (HP:0002013)2.31355499
73Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.30248526
74Cerebral hemorrhage (HP:0001342)2.25785583
75EMG: myopathic abnormalities (HP:0003458)2.25572314
76Abnormality of renal resorption (HP:0011038)2.23407798
77Reduced antithrombin III activity (HP:0001976)2.22449699
78Abnormality of the anterior horn cell (HP:0006802)2.17915381
79Degeneration of anterior horn cells (HP:0002398)2.17915381
80Prolonged QT interval (HP:0001657)2.17781444
81Generalized aminoaciduria (HP:0002909)2.17553166
82Hyperglycinemia (HP:0002154)2.16964667
83Ketoacidosis (HP:0001993)2.15761638
84Muscle stiffness (HP:0003552)2.14721490
85Cerebral palsy (HP:0100021)2.13923278
86Aplastic anemia (HP:0001915)2.13733978
87Abnormal protein glycosylation (HP:0012346)2.08164331
88Abnormal glycosylation (HP:0012345)2.08164331
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08164331
90Abnormal protein N-linked glycosylation (HP:0012347)2.08164331
91Methylmalonic aciduria (HP:0012120)2.07401102
92Esophageal neoplasm (HP:0100751)2.05348333
93Neoplasm of head and neck (HP:0012288)2.05348333
94Abnormality of the heme biosynthetic pathway (HP:0010472)2.04417859
95Progressive external ophthalmoplegia (HP:0000590)2.02642194
96Myokymia (HP:0002411)2.01397345
97Abnormality of placental membranes (HP:0011409)2.00517794
98Amniotic constriction ring (HP:0009775)2.00517794
99Gliosis (HP:0002171)1.97243540
100Left ventricular hypertrophy (HP:0001712)1.97156500
101Testicular atrophy (HP:0000029)1.97105796
102Hyperphosphaturia (HP:0003109)1.95396761
103Hyporeflexia of lower limbs (HP:0002600)1.94409372
104Asymmetric septal hypertrophy (HP:0001670)1.91116186
105Congenital, generalized hypertrichosis (HP:0004540)1.89745529
106Ketosis (HP:0001946)1.89439900
107Paralysis (HP:0003470)1.89127804
108Metabolic acidosis (HP:0001942)1.86767332
109Cholecystitis (HP:0001082)1.86696519
110Abnormal gallbladder physiology (HP:0012438)1.86696519
111Abnormality of the vocal cords (HP:0008777)1.86664291
112Oral leukoplakia (HP:0002745)1.85769433
113Abnormality of cells of the erythroid lineage (HP:0012130)1.84868479
114Ventricular arrhythmia (HP:0004308)1.84575316
115Sparse eyelashes (HP:0000653)1.83318329
116Abnormality of serum amino acid levels (HP:0003112)1.82568996
117Gout (HP:0001997)1.82184006
118Progressive muscle weakness (HP:0003323)1.82136451
119Methylmalonic acidemia (HP:0002912)1.81818517
120Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79673306
121Athetosis (HP:0002305)1.78114373
122Poor suck (HP:0002033)1.77122887
123Neoplasm of the peripheral nervous system (HP:0100007)1.76409143
124Pancytopenia (HP:0001876)1.76125889
125Hyperammonemia (HP:0001987)1.74119650
126Hypoplastic left heart (HP:0004383)1.73547638
127Rimmed vacuoles (HP:0003805)1.73193978
128Ventricular fibrillation (HP:0001663)1.70163611
129Abnormality of methionine metabolism (HP:0010901)1.70140331
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69998624
131Neoplasm of the adrenal gland (HP:0100631)1.69778580
132Abnormal EKG (HP:0003115)1.68742105
133Microvesicular hepatic steatosis (HP:0001414)1.68569218
134Hyperglycinuria (HP:0003108)1.68479001
135Hypoglycemic coma (HP:0001325)1.67524974
136Nausea (HP:0002018)1.66956531
137Blindness (HP:0000618)1.66944777
138Rough bone trabeculation (HP:0100670)1.66536308
139CNS hypomyelination (HP:0003429)1.61769305
140Multiple enchondromatosis (HP:0005701)1.60859099
141Abnormality of the labia minora (HP:0012880)1.60610968
142Unsteady gait (HP:0002317)1.60030163
143Delayed CNS myelination (HP:0002188)1.57860149
144Pallor (HP:0000980)1.56182750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.43112935
2MYLK3.89897356
3MAP3K123.31088805
4BCKDK3.15919058
5NME13.01856739
6NME22.97914534
7OBSCN2.96531985
8MUSK2.62760795
9ARAF2.36889176
10PDK32.29823377
11PDK42.29823377
12STK162.18628434
13GRK72.11220547
14PHKG22.10710085
15PHKG12.10710085
16LIMK12.06687620
17STK392.03611214
18CDC71.99242342
19MAP2K71.98623007
20TTN1.96923195
21WNK41.94005346
22TIE11.80536928
23CASK1.75924810
24CDK191.59301586
25KDR1.55071557
26BUB11.54894280
27GRK51.53363399
28OXSR11.52495356
29PINK11.51992560
30LMTK21.42748717
31TTK1.41667511
32TSSK61.38605881
33PLK31.34202719
34PDK21.31746007
35EIF2AK11.28006916
36CCNB11.26678695
37CAMK2D1.25794471
38MAP2K41.25527259
39MAP3K41.23900807
40CSNK1G21.22854111
41PIK3CA1.21392361
42WEE11.21124015
43TRIM281.20885258
44ZAK1.20624373
45DAPK31.18817793
46PLK41.16420566
47CSNK1G11.14380219
48ILK1.14308788
49PLK11.09408861
50CSNK1A1L1.07367632
51TNIK1.06346354
52CAMK2A1.06004433
53MAPKAPK51.03793359
54PIM21.03424132
55MAP3K111.00373397
56CAMK2G0.96449911
57ABL20.96402770
58BRSK10.95440838
59MAP4K20.92845089
60ADRBK20.91168713
61BMPR1B0.85445276
62PAK40.85281808
63NEK10.84294985
64MAPK120.83879144
65CAMK2B0.82871586
66EIF2AK30.82744917
67PTK2B0.82229123
68TLK10.80689009
69AURKB0.79385553
70ROCK20.79117725
71NTRK30.78691120
72BCR0.78443216
73PBK0.77061977
74PKN10.76031031
75STK240.73377697
76BRAF0.73364831
77MINK10.72696004
78PAK30.71938951
79CAMKK20.71762427
80MST40.70811695
81MARK10.70679221
82SCYL20.70575050
83DYRK30.69814851
84STK40.69605207
85PLK20.69131735
86VRK10.69098489
87UHMK10.68027467
88NUAK10.67165897
89PRKCE0.67057732
90ADRBK10.66729680
91CSNK2A20.66526810
92TESK10.64173231
93PRKACA0.63737329
94CSNK2A10.62406504
95PRKCG0.59736728
96ROCK10.56347695
97MAPK130.56042565
98CAMK10.55826398
99ATR0.55689464
100BMPR20.54875302
101PAK10.53260916
102CHEK20.52359845
103INSRR0.51085189
104RPS6KA50.50657657
105CDK11A0.50508359
106CDK80.50067914
107CDK150.49324540
108GRK10.48651434
109DAPK10.44797704
110ERBB30.42730164
111MAPKAPK30.41962007
112MAP2K60.41597862
113PRKCI0.41374772
114AKT20.41132125
115PNCK0.40966761
116CSNK1G30.40683766
117PRKACB0.40428036
118DYRK20.39987063
119CSNK1A10.39759978
120CSNK1E0.39341416
121TESK20.38616345
122CDK140.38005575
123SRPK10.36561323
124MAPK40.36112889
125CDK50.36018318
126PRKD10.35518904
127LRRK20.35186383
128MAP3K50.33654086
129EPHA40.33306505
130AURKA0.32836431
131SGK2230.32545132
132SGK4940.32545132
133WNK30.31966692
134PRKCD0.31848218
135CDK180.29816619
136PRKACG0.29554032
137MAP2K10.28140613

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.07771029
2Parkinsons disease_Homo sapiens_hsa050125.37131994
3Alzheimers disease_Homo sapiens_hsa050103.98488651
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.82885407
5Huntingtons disease_Homo sapiens_hsa050163.57971162
6Cardiac muscle contraction_Homo sapiens_hsa042603.37844886
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.34052621
8Proteasome_Homo sapiens_hsa030502.76769270
9Ribosome_Homo sapiens_hsa030102.51730841
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.46692033
11Propanoate metabolism_Homo sapiens_hsa006402.34599673
12DNA replication_Homo sapiens_hsa030302.31108045
13Mismatch repair_Homo sapiens_hsa034302.25034581
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23100589
15Fatty acid elongation_Homo sapiens_hsa000622.12100204
16Pyruvate metabolism_Homo sapiens_hsa006202.07811253
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83644952
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82698929
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81601194
20Carbon metabolism_Homo sapiens_hsa012001.77342618
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74613663
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74323399
23Butanoate metabolism_Homo sapiens_hsa006501.68247662
24Base excision repair_Homo sapiens_hsa034101.66259017
25Collecting duct acid secretion_Homo sapiens_hsa049661.62347441
26Fatty acid degradation_Homo sapiens_hsa000711.53066507
27Homologous recombination_Homo sapiens_hsa034401.50809528
28Spliceosome_Homo sapiens_hsa030401.43138452
29Nucleotide excision repair_Homo sapiens_hsa034201.38635832
30Protein export_Homo sapiens_hsa030601.35219012
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28996249
32Sulfur metabolism_Homo sapiens_hsa009201.25783436
33Fatty acid metabolism_Homo sapiens_hsa012121.24143518
34One carbon pool by folate_Homo sapiens_hsa006701.19115449
35RNA polymerase_Homo sapiens_hsa030201.15012586
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11768119
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11517787
38Peroxisome_Homo sapiens_hsa041461.07790459
39RNA transport_Homo sapiens_hsa030131.07656147
40Basal transcription factors_Homo sapiens_hsa030221.06484381
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99678098
42Fanconi anemia pathway_Homo sapiens_hsa034600.98473427
43RNA degradation_Homo sapiens_hsa030180.97933008
44Phenylalanine metabolism_Homo sapiens_hsa003600.97257090
45Non-homologous end-joining_Homo sapiens_hsa034500.94470065
46Dilated cardiomyopathy_Homo sapiens_hsa054140.90549888
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89774191
48* Metabolic pathways_Homo sapiens_hsa011000.87747050
49Biosynthesis of amino acids_Homo sapiens_hsa012300.86898422
50Vibrio cholerae infection_Homo sapiens_hsa051100.86780489
51Tyrosine metabolism_Homo sapiens_hsa003500.85324358
52Vitamin B6 metabolism_Homo sapiens_hsa007500.80891974
53beta-Alanine metabolism_Homo sapiens_hsa004100.79106522
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.76073340
55Arginine and proline metabolism_Homo sapiens_hsa003300.71853521
56Synaptic vesicle cycle_Homo sapiens_hsa047210.71619840
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71572067
58Glutathione metabolism_Homo sapiens_hsa004800.69373703
59Tryptophan metabolism_Homo sapiens_hsa003800.68369239
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66035812
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63801359
62Cell cycle_Homo sapiens_hsa041100.62130675
63Fructose and mannose metabolism_Homo sapiens_hsa000510.55904668
64Oocyte meiosis_Homo sapiens_hsa041140.55615403
65Sulfur relay system_Homo sapiens_hsa041220.54962007
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54430748
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53859219
68PPAR signaling pathway_Homo sapiens_hsa033200.50716102
69Pyrimidine metabolism_Homo sapiens_hsa002400.49761763
70Chemical carcinogenesis_Homo sapiens_hsa052040.49708256
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.48211982
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47743291
73Nicotine addiction_Homo sapiens_hsa050330.45945415
74Pentose phosphate pathway_Homo sapiens_hsa000300.43809594
75Starch and sucrose metabolism_Homo sapiens_hsa005000.43480381
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42061148
77Selenocompound metabolism_Homo sapiens_hsa004500.40794565
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40173170
79N-Glycan biosynthesis_Homo sapiens_hsa005100.39353293
80Histidine metabolism_Homo sapiens_hsa003400.39143626
81Rheumatoid arthritis_Homo sapiens_hsa053230.38522872
82GABAergic synapse_Homo sapiens_hsa047270.38114882
83Arginine biosynthesis_Homo sapiens_hsa002200.37872396
84Purine metabolism_Homo sapiens_hsa002300.37724414
85Taste transduction_Homo sapiens_hsa047420.37596162
86Phototransduction_Homo sapiens_hsa047440.37397834
87Serotonergic synapse_Homo sapiens_hsa047260.37370601
88Nitrogen metabolism_Homo sapiens_hsa009100.36444524
89Galactose metabolism_Homo sapiens_hsa000520.35772677
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35770174
91Folate biosynthesis_Homo sapiens_hsa007900.33313447
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31696802
93Calcium signaling pathway_Homo sapiens_hsa040200.30798526
94Steroid biosynthesis_Homo sapiens_hsa001000.28913731
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28693739
96Arachidonic acid metabolism_Homo sapiens_hsa005900.28188538
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26682125
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24108113
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23054630
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22927349
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22205786
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21981203
103mRNA surveillance pathway_Homo sapiens_hsa030150.21472125
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20275831
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20085899
106Morphine addiction_Homo sapiens_hsa050320.18593380
107Circadian entrainment_Homo sapiens_hsa047130.18028615
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16932272
109Ether lipid metabolism_Homo sapiens_hsa005650.16923060
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16775263
111Fat digestion and absorption_Homo sapiens_hsa049750.16436016
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15930819
113Phagosome_Homo sapiens_hsa041450.14970896
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.14755256
115Regulation of autophagy_Homo sapiens_hsa041400.14295261
116Dopaminergic synapse_Homo sapiens_hsa047280.14204831
117Linoleic acid metabolism_Homo sapiens_hsa005910.13610598
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.13541482
119Glucagon signaling pathway_Homo sapiens_hsa049220.13482795
120Renin secretion_Homo sapiens_hsa049240.12940768
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12777282
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.12711128
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11387496
124Mineral absorption_Homo sapiens_hsa049780.10425834
125Glutamatergic synapse_Homo sapiens_hsa047240.09968186
126Amphetamine addiction_Homo sapiens_hsa050310.09914275
127Gastric acid secretion_Homo sapiens_hsa049710.09115628
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08629186

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