NDUFA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. A pseudogene has been identified on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.73664521
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.32919812
3NADH metabolic process (GO:0006734)6.81496556
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.59854852
5ATP synthesis coupled proton transport (GO:0015986)6.59854852
6* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.05702894
7* respiratory electron transport chain (GO:0022904)6.03902240
8oxidative phosphorylation (GO:0006119)5.87695994
9* electron transport chain (GO:0022900)5.87265985
10oxaloacetate metabolic process (GO:0006107)5.53699492
11regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.51440707
12succinate metabolic process (GO:0006105)5.42681681
13regulation of acyl-CoA biosynthetic process (GO:0050812)5.24111937
14regulation of cofactor metabolic process (GO:0051193)4.93325013
15regulation of coenzyme metabolic process (GO:0051196)4.93325013
16lysine metabolic process (GO:0006553)4.85675286
17lysine catabolic process (GO:0006554)4.85675286
18proteasome assembly (GO:0043248)4.63576652
19aspartate family amino acid catabolic process (GO:0009068)4.59496342
202-oxoglutarate metabolic process (GO:0006103)4.55457365
21respiratory chain complex IV assembly (GO:0008535)4.46836720
22branched-chain amino acid catabolic process (GO:0009083)4.40163176
23ATP biosynthetic process (GO:0006754)4.28293586
24fatty acid beta-oxidation (GO:0006635)4.13894481
25cytochrome complex assembly (GO:0017004)4.13390998
26sarcomere organization (GO:0045214)4.04632243
27aerobic respiration (GO:0009060)4.02066498
28protein complex biogenesis (GO:0070271)3.94380862
29cellular ketone body metabolic process (GO:0046950)3.93871599
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.90658477
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.90658477
32NADH dehydrogenase complex assembly (GO:0010257)3.90658477
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.87555388
34branched-chain amino acid metabolic process (GO:0009081)3.87162799
35regulation of sulfur metabolic process (GO:0042762)3.86785219
36carnitine shuttle (GO:0006853)3.86694888
37pseudouridine synthesis (GO:0001522)3.79889764
38regulation of mitochondrial translation (GO:0070129)3.77798769
39ubiquinone biosynthetic process (GO:0006744)3.76207224
40quinone biosynthetic process (GO:1901663)3.76207224
41mitochondrial respiratory chain complex assembly (GO:0033108)3.73953514
42purine nucleoside triphosphate biosynthetic process (GO:0009145)3.69879792
43fatty acid transmembrane transport (GO:1902001)3.67802689
44fatty acid catabolic process (GO:0009062)3.66648752
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.65460930
46DNA deamination (GO:0045006)3.62459829
47acetyl-CoA metabolic process (GO:0006084)3.59885033
48actin-myosin filament sliding (GO:0033275)3.59781813
49muscle filament sliding (GO:0030049)3.59781813
50tricarboxylic acid metabolic process (GO:0072350)3.59517083
51kynurenine metabolic process (GO:0070189)3.56580087
52fatty acid oxidation (GO:0019395)3.55626528
53short-chain fatty acid metabolic process (GO:0046459)3.52793808
54cardiac myofibril assembly (GO:0055003)3.52685540
55cellular respiration (GO:0045333)3.51447364
56cullin deneddylation (GO:0010388)3.51201014
57lipid oxidation (GO:0034440)3.49368776
58biotin metabolic process (GO:0006768)3.48622610
59ketone body metabolic process (GO:1902224)3.47541000
60inner mitochondrial membrane organization (GO:0007007)3.44525500
61positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.44429058
62hydrogen ion transmembrane transport (GO:1902600)3.39025917
63signal peptide processing (GO:0006465)3.38584944
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37568596
65regulation of sequestering of triglyceride (GO:0010889)3.37209397
66glyoxylate metabolic process (GO:0046487)3.36827588
67transcription elongation from RNA polymerase III promoter (GO:0006385)3.36611176
68termination of RNA polymerase III transcription (GO:0006386)3.36611176
69purine nucleoside monophosphate biosynthetic process (GO:0009127)3.35937368
70purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.35937368
71NAD metabolic process (GO:0019674)3.34910168
72indole-containing compound catabolic process (GO:0042436)3.34823205
73indolalkylamine catabolic process (GO:0046218)3.34823205
74tryptophan catabolic process (GO:0006569)3.34823205
75regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.33537750
76water-soluble vitamin biosynthetic process (GO:0042364)3.33474203
77rRNA modification (GO:0000154)3.32000974
78ubiquinone metabolic process (GO:0006743)3.31021542
79regulation of oxidative phosphorylation (GO:0002082)3.29537482
80regulation of cellular amino acid metabolic process (GO:0006521)3.29163248
81L-phenylalanine metabolic process (GO:0006558)3.28702809
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.28702809
83heart contraction (GO:0060047)3.27089682
84heart process (GO:0003015)3.27089682
85gluconeogenesis (GO:0006094)3.26549696
86peptidyl-histidine modification (GO:0018202)3.26537820
87ribonucleoside triphosphate biosynthetic process (GO:0009201)3.26398500
88monocarboxylic acid catabolic process (GO:0072329)3.25026657
89cardiac muscle contraction (GO:0060048)3.23928409
90protein deneddylation (GO:0000338)3.23370563
91negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.22430137
92carnitine metabolic process (GO:0009437)3.21587250
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20065268
94myofibril assembly (GO:0030239)3.20040126
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.17953226
96hexose biosynthetic process (GO:0019319)3.16886470
97amino-acid betaine metabolic process (GO:0006577)3.16815480
98regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.16753791
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15376506
100valine metabolic process (GO:0006573)3.15331708
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12025385
102L-methionine salvage (GO:0071267)3.11510768
103L-methionine biosynthetic process (GO:0071265)3.11510768
104amino acid salvage (GO:0043102)3.11510768
105DNA double-strand break processing (GO:0000729)3.11378354
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10734678
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10734678
108signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10734678
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.10147405
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10127178
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07498506
112intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07498506
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.07308465
114L-phenylalanine catabolic process (GO:0006559)3.07308465
115indolalkylamine metabolic process (GO:0006586)3.07077634
116mitochondrial transport (GO:0006839)3.06582739
117mannosylation (GO:0097502)3.03510809
118tryptophan metabolic process (GO:0006568)2.99610421
119protein targeting to mitochondrion (GO:0006626)2.99420332
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98547815
121negative regulation of ligase activity (GO:0051352)2.98547815
122nucleoside triphosphate biosynthetic process (GO:0009142)2.98476499
123regulation of cellular respiration (GO:0043457)2.97634473
124proton transport (GO:0015992)2.97250057
125carnitine transmembrane transport (GO:1902603)2.96710396
126chaperone-mediated protein transport (GO:0072321)2.96349105
127monosaccharide biosynthetic process (GO:0046364)2.96022706
128hydrogen transport (GO:0006818)2.95330563
129carnitine transport (GO:0015879)2.94416519
130amino-acid betaine transport (GO:0015838)2.94416519
131signal transduction involved in DNA damage checkpoint (GO:0072422)2.94217658
132signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94217658
133regulation of fatty acid oxidation (GO:0046320)2.94136843
134regulation of skeletal muscle contraction (GO:0014819)2.93087565
135tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92976924
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92976924
137signal transduction involved in cell cycle checkpoint (GO:0072395)2.92102211
138methionine biosynthetic process (GO:0009086)2.91840039
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91343208
140protein neddylation (GO:0045116)2.89913145
141cardiac muscle cell development (GO:0055013)2.89883591
142regulation of glucokinase activity (GO:0033131)2.87623911
143regulation of hexokinase activity (GO:1903299)2.87623911
144ribonucleoside monophosphate biosynthetic process (GO:0009156)2.87339326
145regulation of relaxation of muscle (GO:1901077)2.86930678
146aspartate family amino acid metabolic process (GO:0009066)2.86383271
147maturation of 5.8S rRNA (GO:0000460)2.86350875
148intracellular protein transmembrane import (GO:0044743)2.83546813
149rRNA methylation (GO:0031167)2.83308564
150tRNA processing (GO:0008033)2.82046470
151protein localization to mitochondrion (GO:0070585)2.78377477
152mitochondrial RNA metabolic process (GO:0000959)2.77718663
153establishment of protein localization to mitochondrion (GO:0072655)2.75533399
154protein K6-linked ubiquitination (GO:0085020)2.73214954
155positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69030503
156detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69001566
157aldehyde catabolic process (GO:0046185)2.66181481
158methionine metabolic process (GO:0006555)2.64799221
159response to pheromone (GO:0019236)2.61296683
160positive regulation of ligase activity (GO:0051351)2.57563977
161recombinational repair (GO:0000725)2.56586883
162double-strand break repair via homologous recombination (GO:0000724)2.56050607
163DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.54123043
164DNA catabolic process, exonucleolytic (GO:0000738)2.54003700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.52870523
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.08529551
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.69798971
4* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.10343057
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71895762
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62994316
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42407962
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.32099024
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.30824328
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22184372
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.18423740
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.16056729
13* ETS1_20019798_ChIP-Seq_JURKAT_Human3.03963852
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.89043410
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.86529822
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.83161679
17ZNF274_21170338_ChIP-Seq_K562_Hela2.76131053
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.69104344
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.63908881
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.60216565
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54835227
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47328360
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41753749
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31527619
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.28250005
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.25129035
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25045812
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16650169
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15691685
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09687891
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.05894604
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04971241
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01781098
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96286520
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.94616707
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.92471093
37DCP1A_22483619_ChIP-Seq_HELA_Human1.91041439
38* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79453183
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75068078
40BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.74380918
41EWS_26573619_Chip-Seq_HEK293_Human1.74134136
42IGF1R_20145208_ChIP-Seq_DFB_Human1.73774710
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73665583
44FUS_26573619_Chip-Seq_HEK293_Human1.72082569
45* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71206281
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67643196
47* VDR_23849224_ChIP-Seq_CD4+_Human1.63661998
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62962338
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59891594
50GBX2_23144817_ChIP-Seq_PC3_Human1.56125213
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54455258
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54072217
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53464699
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52583483
55GABP_19822575_ChIP-Seq_HepG2_Human1.51613266
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49444901
57* FOXP3_21729870_ChIP-Seq_TREG_Human1.48765794
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44751154
59XRN2_22483619_ChIP-Seq_HELA_Human1.43292664
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.42892554
61GATA1_22025678_ChIP-Seq_K562_Human1.42695749
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42081795
63P300_19829295_ChIP-Seq_ESCs_Human1.39073863
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39043460
65TP53_22573176_ChIP-Seq_HFKS_Human1.38151317
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37734746
67* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36826111
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34244683
69TAF15_26573619_Chip-Seq_HEK293_Human1.33899151
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33196818
71SOX2_19829295_ChIP-Seq_ESCs_Human1.26447997
72NANOG_19829295_ChIP-Seq_ESCs_Human1.26447997
73* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.26111961
74ER_23166858_ChIP-Seq_MCF-7_Human1.25869417
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25798999
76SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25147673
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25067070
78ZNF263_19887448_ChIP-Seq_K562_Human1.24752780
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24532711
80* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24007370
81CBP_20019798_ChIP-Seq_JUKART_Human1.21150044
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21150044
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20118989
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.19430854
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18453649
86* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18323390
87* FOXA1_25329375_ChIP-Seq_VCAP_Human1.18323390
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16220444
89E2F7_22180533_ChIP-Seq_HELA_Human1.15180876
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15003120
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14644761
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.14572297
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13517047
94AR_20517297_ChIP-Seq_VCAP_Human1.13280560
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12596924
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.11741759
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11457621
98IRF1_19129219_ChIP-ChIP_H3396_Human1.10628931
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.10293120
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08090096
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07896077
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06007965
103TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02802821
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02557100
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01039161
106NCOR_22424771_ChIP-Seq_293T_Human1.00908052
107* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00013895
108ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99958025
109* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98266228
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95573419
111ELK1_19687146_ChIP-ChIP_HELA_Human0.95548559
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94735090
113VDR_22108803_ChIP-Seq_LS180_Human0.94647271
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94571721
115MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93764638
116SALL1_21062744_ChIP-ChIP_HESCs_Human0.93631908
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93376077
118TTF2_22483619_ChIP-Seq_HELA_Human0.93340819
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92466667
120BCAT_22108803_ChIP-Seq_LS180_Human0.92292565
121GATA3_21878914_ChIP-Seq_MCF-7_Human0.92028605
122TCF4_22108803_ChIP-Seq_LS180_Human0.91074358
123HTT_18923047_ChIP-ChIP_STHdh_Human0.90953404
124PHF8_20622853_ChIP-Seq_HELA_Human0.90861928
125MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90516812
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90349964
127RBPJ_21746931_ChIP-Seq_IB4_Human0.89892367
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89672607
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.89650540
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89480070
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89377258
132FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.89166834
133HOXB7_26014856_ChIP-Seq_BT474_Human0.88664824
134TCF4_23295773_ChIP-Seq_U87_Human0.87975480
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87675008
136AR_21909140_ChIP-Seq_LNCAP_Human0.86031905
137TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85436116
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85105470
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.85059034
140ELK1_22589737_ChIP-Seq_MCF10A_Human0.84859766
141SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82933044
142FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81402377
143PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81312283
144CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80215890
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.79915869
146OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79726624
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77489712
148* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76858574
149CLOCK_20551151_ChIP-Seq_293T_Human0.76856009
150SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76616347
151SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76034411
152MYC_18940864_ChIP-ChIP_HL60_Human0.73680230
153FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73355254
154POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73298905
155EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73295055
156* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72437089
157* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71193143
158TBX20_22080862_ChIP-Seq_HEART_Mouse0.70431523
159TBX20_22328084_ChIP-Seq_HEART_Mouse0.70431523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.25980933
2MP0003646_muscle_fatigue4.98344359
3MP0004084_abnormal_cardiac_muscle3.95834193
4MP0003806_abnormal_nucleotide_metabolis3.87965889
5MP0004215_abnormal_myocardial_fiber3.65552019
6MP0006036_abnormal_mitochondrial_physio3.55023521
7MP0000751_myopathy3.52377609
8MP0000372_irregular_coat_pigmentation3.43836107
9MP0005360_urolithiasis3.34050238
10MP0004036_abnormal_muscle_relaxation3.21531536
11MP0002139_abnormal_hepatobiliary_system3.21365598
12MP0000749_muscle_degeneration3.14666832
13MP0005330_cardiomyopathy3.07057561
14MP0005085_abnormal_gallbladder_physiolo2.94544030
15MP0006035_abnormal_mitochondrial_morpho2.51312725
16MP0008058_abnormal_DNA_repair2.48560853
17MP0008057_abnormal_DNA_replication2.48237206
18MP0004130_abnormal_muscle_cell2.37466229
19MP0005365_abnormal_bile_salt2.37281050
20MP0005332_abnormal_amino_acid2.29887218
21MP0008875_abnormal_xenobiotic_pharmacok2.26174207
22MP0002972_abnormal_cardiac_muscle2.22393134
23MP0002102_abnormal_ear_morphology2.15547177
24MP0008775_abnormal_heart_ventricle2.14441102
25MP0005620_abnormal_muscle_contractility2.04179755
26MP0004087_abnormal_muscle_fiber1.99284089
27MP0002269_muscular_atrophy1.98670668
28MP0010094_abnormal_chromosome_stability1.97815598
29MP0003221_abnormal_cardiomyocyte_apopto1.94906735
30MP0003195_calcinosis1.93482583
31MP0003137_abnormal_impulse_conducting1.91286649
32MP0005385_cardiovascular_system_phenoty1.88646568
33MP0001544_abnormal_cardiovascular_syste1.88646568
34MP0008877_abnormal_DNA_methylation1.83461997
35MP0004484_altered_response_of1.82117153
36MP0003186_abnormal_redox_activity1.78670485
37MP0004043_abnormal_pH_regulation1.77904365
38MP0005551_abnormal_eye_electrophysiolog1.77738697
39MP0000569_abnormal_digit_pigmentation1.76265765
40MP0006138_congestive_heart_failure1.70380560
41MP0001764_abnormal_homeostasis1.69629586
42MP0000750_abnormal_muscle_regeneration1.68637486
43MP0002938_white_spotting1.63392169
44MP0000747_muscle_weakness1.61582130
45MP0004147_increased_porphyrin_level1.61254544
46MP0005670_abnormal_white_adipose1.61150005
47MP0002332_abnormal_exercise_endurance1.60789762
48MP0010329_abnormal_lipoprotein_level1.60142033
49MP0002106_abnormal_muscle_physiology1.59729711
50MP0005253_abnormal_eye_physiology1.56879596
51MP0003693_abnormal_embryo_hatching1.53152109
52MP0005075_abnormal_melanosome_morpholog1.47390196
53MP0005266_abnormal_metabolism1.47045352
54MP0004145_abnormal_muscle_electrophysio1.46941060
55MP0006072_abnormal_retinal_apoptosis1.46432218
56MP0005319_abnormal_enzyme/_coenzyme1.46169300
57MP0003786_premature_aging1.42138361
58MP0010630_abnormal_cardiac_muscle1.42101943
59MP0002638_abnormal_pupillary_reflex1.39625216
60MP0000013_abnormal_adipose_tissue1.39561245
61MP0001968_abnormal_touch/_nociception1.34114689
62MP0005584_abnormal_enzyme/coenzyme_acti1.33953893
63MP0005408_hypopigmentation1.33513555
64MP0004085_abnormal_heartbeat1.32971630
65MP0004233_abnormal_muscle_weight1.32801062
66MP0005666_abnormal_adipose_tissue1.32438819
67MP0009840_abnormal_foam_cell1.32414679
68MP0000759_abnormal_skeletal_muscle1.31072316
69MP0005083_abnormal_biliary_tract1.30339462
70MP0001501_abnormal_sleep_pattern1.29169053
71MP0005369_muscle_phenotype1.28067828
72MP0009697_abnormal_copulation1.26476156
73MP0003136_yellow_coat_color1.25015666
74MP0002118_abnormal_lipid_homeostasis1.17831034
75MP0005410_abnormal_fertilization1.17634530
76MP0004957_abnormal_blastocyst_morpholog1.17141633
77MP0003656_abnormal_erythrocyte_physiolo1.15788553
78MP0005535_abnormal_body_temperature1.11224216
79MP0002234_abnormal_pharynx_morphology1.10016522
80MP0002127_abnormal_cardiovascular_syste1.09409821
81MP0002876_abnormal_thyroid_physiology1.09336555
82MP0009745_abnormal_behavioral_response1.07515237
83MP0001986_abnormal_taste_sensitivity1.06899728
84MP0005645_abnormal_hypothalamus_physiol1.05953696
85MP0009643_abnormal_urine_homeostasis1.05168014
86MP0002272_abnormal_nervous_system1.04080838
87MP0002971_abnormal_brown_adipose1.03584028
88MP0001666_abnormal_nutrient_absorption1.03161258
89MP0002095_abnormal_skin_pigmentation1.02522597
90MP0001485_abnormal_pinna_reflex1.02480279
91MP0000427_abnormal_hair_cycle1.01823526
92MP0000230_abnormal_systemic_arterial1.01475611
93MP0001529_abnormal_vocalization0.98845235
94MP0002090_abnormal_vision0.97352316
95MP0006276_abnormal_autonomic_nervous0.96978543
96MP0005376_homeostasis/metabolism_phenot0.94937876
97MP0003252_abnormal_bile_duct0.94592142
98MP0003950_abnormal_plasma_membrane0.93371900
99MP0005636_abnormal_mineral_homeostasis0.91968542
100MP0001756_abnormal_urination0.90719735
101MP0005174_abnormal_tail_pigmentation0.89789458
102MP0002735_abnormal_chemical_nociception0.89497161
103MP0003077_abnormal_cell_cycle0.89285091
104MP0000609_abnormal_liver_physiology0.89243799
105MP0002078_abnormal_glucose_homeostasis0.88908088
106MP0005165_increased_susceptibility_to0.88798105
107MP0004019_abnormal_vitamin_homeostasis0.88364269
108MP0002138_abnormal_hepatobiliary_system0.86772152
109MP0003111_abnormal_nucleus_morphology0.85397403
110MP0002163_abnormal_gland_morphology0.85044687
111MP0002822_catalepsy0.83298425
112MP0002160_abnormal_reproductive_system0.82328722
113MP0003191_abnormal_cellular_cholesterol0.82181262
114MP0001984_abnormal_olfaction0.81976893
115MP0000358_abnormal_cell_content/0.78301394
116MP0005395_other_phenotype0.77814360
117MP0000343_altered_response_to0.77702544
118MP0001929_abnormal_gametogenesis0.77528193
119MP0008007_abnormal_cellular_replicative0.77161908
120MP0005375_adipose_tissue_phenotype0.76878889
121MP0005084_abnormal_gallbladder_morpholo0.75996714
122MP0005451_abnormal_body_composition0.75715813
123MP0005646_abnormal_pituitary_gland0.71317779
124MP0010386_abnormal_urinary_bladder0.69607402
125MP0008004_abnormal_stomach_pH0.69187603
126MP0002064_seizures0.68994650
127MP0003698_abnormal_male_reproductive0.68353162
128MP0002210_abnormal_sex_determination0.68002891
129MP0002067_abnormal_sensory_capabilities0.67800561
130MP0005379_endocrine/exocrine_gland_phen0.67437681
131MP0003718_maternal_effect0.66282142
132MP0008872_abnormal_physiological_respon0.65468579
133MP0004142_abnormal_muscle_tone0.62330122
134MP0002736_abnormal_nociception_after0.61668019
135MP0003828_pulmonary_edema0.61488549
136MP0001661_extended_life_span0.57056171
137MP0004185_abnormal_adipocyte_glucose0.55312649
138MP0003567_abnormal_fetal_cardiomyocyte0.54852896
139MP0003880_abnormal_central_pattern0.54653568
140MP0000003_abnormal_adipose_tissue0.54568838
141MP0009046_muscle_twitch0.52337890
142MP0005386_behavior/neurological_phenoty0.51221637
143MP0004924_abnormal_behavior0.51221637
144MP0003011_delayed_dark_adaptation0.50857324
145MP0001905_abnormal_dopamine_level0.49511955
146MP0001727_abnormal_embryo_implantation0.48284736
147MP0000598_abnormal_liver_morphology0.48213445
148MP0005334_abnormal_fat_pad0.48084674
149MP0009642_abnormal_blood_homeostasis0.47739502

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.51773163
2Acute necrotizing encephalopathy (HP:0006965)5.48555858
3Acute encephalopathy (HP:0006846)5.16639406
4* Hepatic necrosis (HP:0002605)5.01582960
5* Mitochondrial inheritance (HP:0001427)4.71074834
6* Hepatocellular necrosis (HP:0001404)4.69746190
7* Increased CSF lactate (HP:0002490)4.55611988
8Cerebral edema (HP:0002181)4.51846314
9Progressive macrocephaly (HP:0004481)4.51646098
10Abnormality of glycolysis (HP:0004366)4.43298519
11Increased serum pyruvate (HP:0003542)4.43298519
12Myoglobinuria (HP:0002913)4.22268599
13Sudden death (HP:0001699)3.96412908
14* Lactic acidosis (HP:0003128)3.92940264
15Exercise-induced muscle cramps (HP:0003710)3.87705357
16Exercise-induced myalgia (HP:0003738)3.85641056
17Increased muscle lipid content (HP:0009058)3.85615981
18Abnormality of fatty-acid metabolism (HP:0004359)3.77368164
19Rhabdomyolysis (HP:0003201)3.65450061
20Hyperglycinuria (HP:0003108)3.65409439
21Increased intramyocellular lipid droplets (HP:0012240)3.64507741
22Palpitations (HP:0001962)3.64407867
23Abnormality of alanine metabolism (HP:0010916)3.63088643
24Hyperalaninemia (HP:0003348)3.63088643
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.63088643
26Abnormality of dicarboxylic acid metabolism (HP:0010995)3.57604650
27Dicarboxylic aciduria (HP:0003215)3.57604650
28Ketoacidosis (HP:0001993)3.54573904
29Calf muscle hypertrophy (HP:0008981)3.47340017
30Exercise intolerance (HP:0003546)3.43698218
31Lipid accumulation in hepatocytes (HP:0006561)3.41626146
32Hyperammonemia (HP:0001987)3.41509006
33* Respiratory failure (HP:0002878)3.41040475
34Lethargy (HP:0001254)3.36487397
35* Increased serum lactate (HP:0002151)3.32954250
36Hypoglycemic coma (HP:0001325)3.31766988
37Muscle hypertrophy of the lower extremities (HP:0008968)3.30595341
38Ventricular tachycardia (HP:0004756)3.28567307
39Pancreatic cysts (HP:0001737)3.25846559
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.25660259
41Decreased activity of mitochondrial respiratory chain (HP:0008972)3.25660259
42Ketosis (HP:0001946)3.24465188
43Abnormality of glycine metabolism (HP:0010895)3.22512235
44Abnormality of serine family amino acid metabolism (HP:0010894)3.22512235
45Pheochromocytoma (HP:0002666)3.15705358
46Increased hepatocellular lipid droplets (HP:0006565)3.09713909
47Nemaline bodies (HP:0003798)3.09073368
48Neuroendocrine neoplasm (HP:0100634)3.06839333
49Birth length less than 3rd percentile (HP:0003561)3.06830723
50Hyperglycinemia (HP:0002154)3.02140183
51Muscle fiber inclusion bodies (HP:0100299)2.94157394
52Ragged-red muscle fibers (HP:0003200)2.92508632
53Generalized aminoaciduria (HP:0002909)2.86544884
54Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.85740191
55* CNS demyelination (HP:0007305)2.84082350
56Type I transferrin isoform profile (HP:0003642)2.82273704
573-Methylglutaconic aciduria (HP:0003535)2.81063679
58Lipoatrophy (HP:0100578)2.78537394
59Conjunctival hamartoma (HP:0100780)2.77964419
60Pancreatic fibrosis (HP:0100732)2.75996167
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74472244
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69385031
63Metabolic acidosis (HP:0001942)2.68939522
64Atrial fibrillation (HP:0005110)2.66919303
65Muscle fiber splitting (HP:0003555)2.63639745
66Abnormality of the calf musculature (HP:0001430)2.62504574
67Abnormality of serum amino acid levels (HP:0003112)2.61711249
68Proximal tubulopathy (HP:0000114)2.59873768
69Leukodystrophy (HP:0002415)2.59046473
70Vomiting (HP:0002013)2.54890889
71Gout (HP:0001997)2.54614316
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.53497106
73Abnormal protein N-linked glycosylation (HP:0012347)2.53497106
74Abnormal protein glycosylation (HP:0012346)2.53497106
75Abnormal glycosylation (HP:0012345)2.53497106
76Syncope (HP:0001279)2.52578231
77Congenital stationary night blindness (HP:0007642)2.51600938
78Nausea (HP:0002018)2.50643107
79Supraventricular tachycardia (HP:0004755)2.46904413
80Optic disc pallor (HP:0000543)2.46372657
81Abnormality of midbrain morphology (HP:0002418)2.45815094
82Molar tooth sign on MRI (HP:0002419)2.45815094
83Dilated cardiomyopathy (HP:0001644)2.45664932
84Abnormality of urine glucose concentration (HP:0011016)2.44768108
85Glycosuria (HP:0003076)2.44768108
86Primary atrial arrhythmia (HP:0001692)2.44268566
87Neoplasm of the adrenal gland (HP:0100631)2.43874421
88Methylmalonic aciduria (HP:0012120)2.43623270
89Neoplasm of head and neck (HP:0012288)2.39239186
90Esophageal neoplasm (HP:0100751)2.39239186
91Supraventricular arrhythmia (HP:0005115)2.38755161
92Renal Fanconi syndrome (HP:0001994)2.35483392
93Abnormality of the renal cortex (HP:0011035)2.32832541
94True hermaphroditism (HP:0010459)2.32107111
95Abnormality of aromatic amino acid family metabolism (HP:0004338)2.26921761
96Right ventricular cardiomyopathy (HP:0011663)2.26252053
97Large for gestational age (HP:0001520)2.25894513
98Muscle stiffness (HP:0003552)2.24305464
99Cholelithiasis (HP:0001081)2.20822448
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18526248
101Respiratory difficulties (HP:0002880)2.17694096
102EMG: myopathic abnormalities (HP:0003458)2.15548643
103Ventricular fibrillation (HP:0001663)2.15417140
104Hypobetalipoproteinemia (HP:0003563)2.14960114
105Myotonia (HP:0002486)2.14630498
106Ventricular arrhythmia (HP:0004308)2.12000974
107Methylmalonic acidemia (HP:0002912)2.11605400
108* Emotional lability (HP:0000712)2.11072892
109Hyperventilation (HP:0002883)2.09598633
110Renal cortical cysts (HP:0000803)2.08895505
111Abnormal gallbladder morphology (HP:0012437)2.07629209
112Congenital, generalized hypertrichosis (HP:0004540)2.06536986
113Hyporeflexia of lower limbs (HP:0002600)2.06278593
114Nephronophthisis (HP:0000090)2.04986169
115Hypolipoproteinemia (HP:0010981)2.02759268
116Reduced antithrombin III activity (HP:0001976)2.01453492
117Hyperuricemia (HP:0002149)2.00443914
118Increased purine levels (HP:0004368)2.00443914
119Inability to walk (HP:0002540)2.00442581
120Athetosis (HP:0002305)1.98630758
121Bundle branch block (HP:0011710)1.97944290
122Hypoalphalipoproteinemia (HP:0003233)1.97396322
123Prolonged QT interval (HP:0001657)1.97322529
124Gaze-evoked nystagmus (HP:0000640)1.96882866
125* Gliosis (HP:0002171)1.95494259
126Exertional dyspnea (HP:0002875)1.93331456
127Progressive inability to walk (HP:0002505)1.90250628
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.90247546
129Medial flaring of the eyebrow (HP:0010747)1.89144093
130X-linked dominant inheritance (HP:0001423)1.86027930
131Microvesicular hepatic steatosis (HP:0001414)1.85643666
132Attenuation of retinal blood vessels (HP:0007843)1.83572926
133Abnormality of the pons (HP:0007361)1.81378371
134Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81042085
135Sclerocornea (HP:0000647)1.80376279
136Hypoplasia of the pons (HP:0012110)1.79799022
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78673231
138Type II lissencephaly (HP:0007260)1.77130457
139Hypoplasia of the fovea (HP:0007750)1.76636175
140Aplasia/Hypoplasia of the fovea (HP:0008060)1.76636175
141Abnormality of the renal medulla (HP:0100957)1.76294834
142Hypothermia (HP:0002045)1.75990363
143Abnormality of methionine metabolism (HP:0010901)1.75899923
144Opisthotonus (HP:0002179)1.73632972
145Abnormality of renal resorption (HP:0011038)1.72303550
146Broad-based gait (HP:0002136)1.69577547
147Pendular nystagmus (HP:0012043)1.68134130
148Aplasia/Hypoplasia involving the musculature (HP:0001460)1.68122400
149Amniotic constriction ring (HP:0009775)1.67674833
150Abnormality of placental membranes (HP:0011409)1.67674833
151Abnormality of macular pigmentation (HP:0008002)1.65297295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.89050300
2PDK34.89050300
3BCKDK4.83072385
4FRK4.75751269
5NEK13.85918150
6OBSCN3.48156640
7PDK23.25376674
8MYLK3.22241925
9BMPR1B3.13756480
10VRK22.92754487
11ACVR1B2.91365548
12EIF2AK12.73269834
13BUB12.68590609
14NME12.57317024
15TTN2.56821761
16LMTK22.41468805
17NUAK12.28285128
18PHKG22.16653288
19PHKG12.16653288
20TRIM282.02771463
21STK161.91200678
22STK38L1.84480718
23MAP4K21.81572720
24PINK11.79653229
25ADRBK21.76616953
26TSSK61.76444109
27NME21.62564647
28MAP3K121.62285798
29GRK11.51092573
30STK241.48651174
31SRPK11.46476786
32ZAK1.34250858
33CCNB11.33945182
34WNK41.30549598
35MKNK21.25123497
36EIF2AK31.16966539
37PKN21.15061128
38WEE11.15031676
39OXSR11.10887433
40PIK3CA1.09773954
41CASK1.06273827
42ILK1.03465160
43CDC70.97688329
44TGFBR10.96711779
45DAPK30.95769022
46TLK10.94413910
47CDK190.92395750
48GRK70.88637818
49KDR0.87654380
50NEK90.87533434
51TIE10.83559491
52CAMK2D0.81948845
53MAP2K40.81891139
54ERBB30.81679980
55LIMK10.81212122
56CSNK1G10.80234309
57PLK20.80092707
58CSNK1G30.78882453
59MUSK0.78482560
60TRIB30.77674651
61CDK80.77590471
62CAMK2G0.76690326
63TAF10.76567039
64FLT30.75266074
65AKT30.73948471
66DAPK10.70420688
67BRSK20.69928749
68MAP3K40.69786104
69MAP3K110.69120470
70TNIK0.69023979
71MAP2K70.67723103
72CSNK1A1L0.67640441
73MKNK10.66454260
74BRAF0.66022094
75MAPK130.64337099
76MAPK120.63724256
77MAPKAPK30.62979895
78ADRBK10.62596780
79CSNK1G20.62192162
80ARAF0.62117861
81WNK30.61192128
82TTK0.60958206
83MST1R0.60803451
84STK390.60329658
85CAMKK20.60171175
86BRSK10.58115927
87EIF2AK20.57310705
88EPHA40.54700416
89ATR0.54650662
90TXK0.52247604
91AURKA0.51979136
92RPS6KA50.51891971
93MAPKAPK50.50923218
94MAP3K50.50408364
95CAMK2A0.49933889
96PBK0.49613861
97PIM20.48931605
98CHEK20.48784012
99TAOK30.47668847
100ABL20.47309368
101PRKCG0.45586473
102PLK30.45024642
103PLK40.44894440
104MAP2K60.44643373
105PIK3CG0.44585386
106PDPK10.42521706
107PRKACA0.42107602
108MAP3K30.42058722
109MAP2K30.41576148
110MAPK110.41321178
111PRKAA10.39993045
112AURKB0.38579648
113CAMK2B0.38497946
114PLK10.38114099
115CSNK1A10.36577524
116PRKACB0.36231150
117PAK30.32870208
118PRKACG0.32664178
119TEC0.32472788
120PDK10.32205252
121NTRK30.32165900
122DAPK20.31984630
123PRKAA20.30679941
124ROCK10.30535868
125VRK10.30494605
126STK30.29979735
127DYRK20.29819381
128ERBB40.29731593
129IKBKB0.29616132
130MST40.28772768
131CSNK2A10.27754053
132INSRR0.26536579
133TESK10.25986520
134BCR0.24604136
135MAP2K10.24213320
136STK40.23812107
137GRK50.23627422
138PRKCE0.23158351
139CSNK2A20.22121798
140RPS6KC10.22111692
141RPS6KL10.22111692
142PTK2B0.22030048

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.25322457
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.95517986
3* Oxidative phosphorylation_Homo sapiens_hsa001903.72693641
4Parkinsons disease_Homo sapiens_hsa050123.35909387
5Propanoate metabolism_Homo sapiens_hsa006403.27392012
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23974353
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99728365
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.73714104
9Fatty acid degradation_Homo sapiens_hsa000712.71596276
10Carbon metabolism_Homo sapiens_hsa012002.66360349
11Pyruvate metabolism_Homo sapiens_hsa006202.59464740
12Alzheimers disease_Homo sapiens_hsa050102.30957730
13Proteasome_Homo sapiens_hsa030502.29131753
14Homologous recombination_Homo sapiens_hsa034402.27735721
15Huntingtons disease_Homo sapiens_hsa050162.20806634
16Cardiac muscle contraction_Homo sapiens_hsa042602.14237029
17Fatty acid metabolism_Homo sapiens_hsa012122.13936740
18* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07879616
19Butanoate metabolism_Homo sapiens_hsa006502.01635393
20Fatty acid elongation_Homo sapiens_hsa000621.85677624
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81041652
22Biosynthesis of amino acids_Homo sapiens_hsa012301.76954105
23Non-homologous end-joining_Homo sapiens_hsa034501.59519438
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58742650
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58380020
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56757816
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56533342
28Tryptophan metabolism_Homo sapiens_hsa003801.47342609
29Peroxisome_Homo sapiens_hsa041461.45911022
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.41730207
31Fanconi anemia pathway_Homo sapiens_hsa034601.40801317
32Arginine biosynthesis_Homo sapiens_hsa002201.39737076
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.36409105
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34383912
35beta-Alanine metabolism_Homo sapiens_hsa004101.30586270
36Basal transcription factors_Homo sapiens_hsa030221.25770873
37RNA degradation_Homo sapiens_hsa030181.25043534
38PPAR signaling pathway_Homo sapiens_hsa033201.21176808
39Phenylalanine metabolism_Homo sapiens_hsa003601.12205518
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08918188
41Phototransduction_Homo sapiens_hsa047441.07502596
42Vitamin B6 metabolism_Homo sapiens_hsa007501.01722887
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00651265
44Linoleic acid metabolism_Homo sapiens_hsa005910.98709939
45Fructose and mannose metabolism_Homo sapiens_hsa000510.96470528
46Pentose phosphate pathway_Homo sapiens_hsa000300.94195577
47Collecting duct acid secretion_Homo sapiens_hsa049660.93112253
48Sulfur metabolism_Homo sapiens_hsa009200.91881098
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90362664
50Tyrosine metabolism_Homo sapiens_hsa003500.90320153
51Arginine and proline metabolism_Homo sapiens_hsa003300.87639357
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85136479
53Base excision repair_Homo sapiens_hsa034100.83883875
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83483112
55* Metabolic pathways_Homo sapiens_hsa011000.83291282
56Ribosome_Homo sapiens_hsa030100.82348420
57Starch and sucrose metabolism_Homo sapiens_hsa005000.82127703
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79825166
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79341469
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78600493
61RNA polymerase_Homo sapiens_hsa030200.78340477
62Folate biosynthesis_Homo sapiens_hsa007900.76125985
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70382739
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69908517
65Glutathione metabolism_Homo sapiens_hsa004800.69237574
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.67383967
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.67021643
68Galactose metabolism_Homo sapiens_hsa000520.65446626
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65332082
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64768988
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.64273190
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62053566
73Dilated cardiomyopathy_Homo sapiens_hsa054140.61633516
74Selenocompound metabolism_Homo sapiens_hsa004500.60674819
75Fat digestion and absorption_Homo sapiens_hsa049750.59214803
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57869345
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57271109
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57188811
79Spliceosome_Homo sapiens_hsa030400.56626724
80Sulfur relay system_Homo sapiens_hsa041220.54431171
81Glycerolipid metabolism_Homo sapiens_hsa005610.53248022
82Mineral absorption_Homo sapiens_hsa049780.53057566
83Pyrimidine metabolism_Homo sapiens_hsa002400.52754349
84Ether lipid metabolism_Homo sapiens_hsa005650.52336955
85Chemical carcinogenesis_Homo sapiens_hsa052040.51574366
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50190245
87Histidine metabolism_Homo sapiens_hsa003400.45136833
88Nitrogen metabolism_Homo sapiens_hsa009100.44364899
89Vibrio cholerae infection_Homo sapiens_hsa051100.44214686
90Nicotine addiction_Homo sapiens_hsa050330.40745392
91Asthma_Homo sapiens_hsa053100.40632800
92Retinol metabolism_Homo sapiens_hsa008300.38750767
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.38345570
94One carbon pool by folate_Homo sapiens_hsa006700.37718772
95Systemic lupus erythematosus_Homo sapiens_hsa053220.37316766
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35685712
97Glucagon signaling pathway_Homo sapiens_hsa049220.35249688
98Olfactory transduction_Homo sapiens_hsa047400.34767668
99Arachidonic acid metabolism_Homo sapiens_hsa005900.34731457
100Purine metabolism_Homo sapiens_hsa002300.33845044
101Bile secretion_Homo sapiens_hsa049760.33045494
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32919874
103Taste transduction_Homo sapiens_hsa047420.31348879
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30058807
105Protein export_Homo sapiens_hsa030600.29075653
106Complement and coagulation cascades_Homo sapiens_hsa046100.28239607
107Synaptic vesicle cycle_Homo sapiens_hsa047210.27471492
108Fatty acid biosynthesis_Homo sapiens_hsa000610.27168143
109Mismatch repair_Homo sapiens_hsa034300.26613021
110Vitamin digestion and absorption_Homo sapiens_hsa049770.26371188
111Regulation of autophagy_Homo sapiens_hsa041400.26116432
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.25393614
113DNA replication_Homo sapiens_hsa030300.22493368
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.15044365
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.13811554
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.10951996
117Caffeine metabolism_Homo sapiens_hsa002320.10895119
118AMPK signaling pathway_Homo sapiens_hsa041520.10112256
119Nucleotide excision repair_Homo sapiens_hsa034200.09664662
120Insulin signaling pathway_Homo sapiens_hsa049100.09392601
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08608340
122Steroid biosynthesis_Homo sapiens_hsa001000.07188614
123Insulin resistance_Homo sapiens_hsa049310.06521479
124RNA transport_Homo sapiens_hsa030130.06303992
125ABC transporters_Homo sapiens_hsa020100.05015638

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