ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	7.86047023
2	regulation of mitotic spindle organization (GO:0060236)	5.49304799
3	hindbrain development (GO:0030902)	5.28757826
4	mitochondrial DNA replication (GO:0006264)	5.16240583
5	neuron remodeling (GO:0016322)	5.09523246
6	S-adenosylmethionine metabolic process (GO:0046500)	4.72891606
7	DNA replication checkpoint (GO:0000076)	4.43973594
8	atrial cardiac muscle cell action potential (GO:0086014)	4.14611689
9	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.07666434
10	regulation of spindle organization (GO:0090224)	3.92267990
11	lateral sprouting from an epithelium (GO:0060601)	3.89351701
12	regulation of translation, ncRNA-mediated (GO:0045974)	3.85707001
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.85707001
14	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.85707001
15	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.81804942
16	limb bud formation (GO:0060174)	3.70165839
17	substrate-dependent cell migration (GO:0006929)	3.62454153
18	left/right axis specification (GO:0070986)	3.60832683
19	pituitary gland development (GO:0021983)	3.59209977
20	replication fork processing (GO:0031297)	3.55275385
21	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.53778885
22	regulation of mitotic spindle checkpoint (GO:1903504)	3.53778885
23	regulation of transforming growth factor beta2 production (GO:0032909)	3.51657237
24	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.51407941
25	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.50913001
26	L-fucose catabolic process (GO:0042355)	3.43051523
27	fucose catabolic process (GO:0019317)	3.43051523
28	L-fucose metabolic process (GO:0042354)	3.43051523
29	DNA-dependent DNA replication (GO:0006261)	3.42266311
30	regulation of hippo signaling (GO:0035330)	3.41772345
31	generation of neurons (GO:0048699)	3.41420422
32	sulfation (GO:0051923)	3.41312362
33	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.40715718
34	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.39531640
35	regulation of timing of cell differentiation (GO:0048505)	3.38050559
36	DNA catabolic process, exonucleolytic (GO:0000738)	3.35172881
37	nonmotile primary cilium assembly (GO:0035058)	3.29721461
38	genitalia morphogenesis (GO:0035112)	3.29159239
39	otic vesicle formation (GO:0030916)	3.24995424
40	positive regulation of receptor activity (GO:2000273)	3.22766200
41	regulation of cilium movement (GO:0003352)	3.19466174
42	mitochondrial DNA metabolic process (GO:0032042)	3.19143971
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.17923821
44	chromatin remodeling at centromere (GO:0031055)	3.14875545
45	centriole replication (GO:0007099)	3.11950113
46	nephron epithelium morphogenesis (GO:0072088)	3.11597286
47	nephron tubule morphogenesis (GO:0072078)	3.11597286
48	head development (GO:0060322)	3.08531268
49	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.06578071
50	retinal cone cell development (GO:0046549)	3.06151470
51	telomere maintenance via semi-conservative replication (GO:0032201)	3.05731231
52	regulation of meiosis I (GO:0060631)	3.00993012
53	renal tubule morphogenesis (GO:0061333)	2.96111898
54	ephrin receptor signaling pathway (GO:0048013)	2.95477454
55	organ formation (GO:0048645)	2.93515029
56	central nervous system projection neuron axonogenesis (GO:0021952)	2.92817479
57	microtubule depolymerization (GO:0007019)	2.92114664
58	recombinational repair (GO:0000725)	2.88158731
59	double-strand break repair via homologous recombination (GO:0000724)	2.87488867
60	presynaptic membrane assembly (GO:0097105)	2.87347676
61	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.87238645
62	somite development (GO:0061053)	2.87217175
63	olfactory bulb development (GO:0021772)	2.86681084
64	central nervous system neuron axonogenesis (GO:0021955)	2.86419256
65	regulation of development, heterochronic (GO:0040034)	2.86408335
66	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.86156855
67	presynaptic membrane organization (GO:0097090)	2.85881086
68	flavonoid metabolic process (GO:0009812)	2.83633187
69	neuron maturation (GO:0042551)	2.81993626
70	protein K11-linked deubiquitination (GO:0035871)	2.81548656
71	protein K6-linked ubiquitination (GO:0085020)	2.80452666
72	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	2.78338349
73	tryptophan catabolic process (GO:0006569)	2.77931297
74	indole-containing compound catabolic process (GO:0042436)	2.77931297
75	indolalkylamine catabolic process (GO:0046218)	2.77931297
76	telomere maintenance via recombination (GO:0000722)	2.77327602
77	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.76705526
78	heart field specification (GO:0003128)	2.75684027
79	secondary heart field specification (GO:0003139)	2.75684027
80	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.75613433
81	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.74397914
82	regulation of centriole replication (GO:0046599)	2.72177673
83	mitotic recombination (GO:0006312)	2.71968175
84	histone H2A acetylation (GO:0043968)	2.70193010
85	pancreas development (GO:0031016)	2.68552294
86	negative regulation of dendrite development (GO:2000171)	2.66521562
87	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.65899705
88	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.65899705
89	tryptophan metabolic process (GO:0006568)	2.65324791
90	axoneme assembly (GO:0035082)	2.64793329
91	negative regulation of translational initiation (GO:0045947)	2.64549458
92	cilium morphogenesis (GO:0060271)	2.63068611
93	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.62189629
94	regulation of triglyceride biosynthetic process (GO:0010866)	2.61960573
95	keratinocyte development (GO:0003334)	2.60376648
96	epithelial cilium movement (GO:0003351)	2.59057160
97	positive regulation of gluconeogenesis (GO:0045722)	2.57337271
98	indolalkylamine metabolic process (GO:0006586)	2.55206581
99	polyol catabolic process (GO:0046174)	2.52791859
100	adenosine metabolic process (GO:0046085)	2.52006677

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.59728873
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23504753
3	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.11774125
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.09825478
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.96795767
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.93715186
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.88048824
8	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.64195568
9	VDR_22108803_ChIP-Seq_LS180_Human	2.59287449
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53466166
11	FUS_26573619_Chip-Seq_HEK293_Human	2.51195173
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.41028491
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.40816612
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.34475466
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.32535703
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.11905126
17	P300_19829295_ChIP-Seq_ESCs_Human	2.10774849
18	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.10306589
19	EWS_26573619_Chip-Seq_HEK293_Human	2.09744401
20	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.00566565
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.98966871
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.98225864
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98205839
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.92643666
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.86599021
26	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.75084945
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.74964369
28	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.72166924
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.69307522
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67914754
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67484918
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.62453558
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.61815330
34	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.61147577
35	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.59122965
36	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58259352
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.55280943
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.55280943
39	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54595040
40	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.53780718
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.51462980
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.51273388
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50877358
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.49662818
45	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.49549987
46	AR_25329375_ChIP-Seq_VCAP_Human	1.48203165
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.46149665
48	STAT3_23295773_ChIP-Seq_U87_Human	1.44252587
49	P53_22387025_ChIP-Seq_ESCs_Mouse	1.43636585
50	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.41439425
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41313521
52	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.41035703
53	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.40319575
54	TCF4_23295773_ChIP-Seq_U87_Human	1.38389508
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.38016633
56	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37407903
57	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.34570570
58	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.34367345
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31685480
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31592345
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31133243
62	P300_18555785_Chip-Seq_ESCs_Mouse	1.29205148
63	EZH2_22144423_ChIP-Seq_EOC_Human	1.29065345
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.27627644
65	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.27378995
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.26712336
67	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.25677975
68	ER_23166858_ChIP-Seq_MCF-7_Human	1.24224373
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23788968
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22875065
71	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.20388217
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20152794
73	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.19023999
74	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.17546619
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16087879
76	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.14683683
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14605672
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14605672
79	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14016405
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14016405
81	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.13954322
82	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.13088575
83	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.12873781
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12315954
85	AHR_22903824_ChIP-Seq_MCF-7_Human	1.11506427
86	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10332993
87	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.09684053
88	E2F7_22180533_ChIP-Seq_HELA_Human	1.08358855
89	TP53_22573176_ChIP-Seq_HFKS_Human	1.07606555
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07371934
91	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05010809
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03347182
93	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03065461
94	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02678177
95	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.02298706
96	ELK1_19687146_ChIP-ChIP_HELA_Human	1.00812682
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97909165
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.96569098
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.95982395
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95761685

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.80645511
2	MP0002160_abnormal_reproductive_system	3.13109842
3	MP0008877_abnormal_DNA_methylation	3.04296147
4	MP0001919_abnormal_reproductive_system	2.91971130
5	MP0003950_abnormal_plasma_membrane	2.62041188
6	MP0005551_abnormal_eye_electrophysiolog	2.55179621
7	MP0004147_increased_porphyrin_level	2.41149177
8	MP0000569_abnormal_digit_pigmentation	2.33927462
9	MP0003787_abnormal_imprinting	2.32233414
10	MP0006072_abnormal_retinal_apoptosis	2.30295086
11	MP0001727_abnormal_embryo_implantation	2.16289217
12	MP0002102_abnormal_ear_morphology	2.00410723
13	MP0005389_reproductive_system_phenotype	1.95068501
14	MP0003195_calcinosis	1.93443764
15	MP0008058_abnormal_DNA_repair	1.90048319
16	MP0008789_abnormal_olfactory_epithelium	1.84019964
17	MP0001529_abnormal_vocalization	1.74990074
18	MP0003567_abnormal_fetal_cardiomyocyte	1.71681392
19	MP0002736_abnormal_nociception_after	1.69712586
20	MP0000631_abnormal_neuroendocrine_gland	1.67737638
21	MP0000778_abnormal_nervous_system	1.62974272
22	MP0005248_abnormal_Harderian_gland	1.61572333
23	MP0004885_abnormal_endolymph	1.58228752
24	MP0001486_abnormal_startle_reflex	1.56362029
25	MP0000516_abnormal_urinary_system	1.55564450
26	MP0005367_renal/urinary_system_phenotyp	1.55564450
27	MP0005253_abnormal_eye_physiology	1.55139948
28	MP0001188_hyperpigmentation	1.54520572
29	MP0009697_abnormal_copulation	1.49540831
30	MP0000427_abnormal_hair_cycle	1.49217522
31	MP0003121_genomic_imprinting	1.47163147
32	MP0003718_maternal_effect	1.45321649
33	MP0003880_abnormal_central_pattern	1.42747097
34	MP0001968_abnormal_touch/_nociception	1.40308538
35	MP0002234_abnormal_pharynx_morphology	1.39885039
36	MP0002837_dystrophic_cardiac_calcinosis	1.39204322
37	MP0001984_abnormal_olfaction	1.37710677
38	MP0000049_abnormal_middle_ear	1.36530677
39	MP0004133_heterotaxia	1.34631100
40	MP0000613_abnormal_salivary_gland	1.33265707
41	MP0005386_behavior/neurological_phenoty	1.32673988
42	MP0004924_abnormal_behavior	1.32673988
43	MP0002254_reproductive_system_inflammat	1.32337607
44	MP0004134_abnormal_chest_morphology	1.31263511
45	MP0003693_abnormal_embryo_hatching	1.28565954
46	MP0001299_abnormal_eye_distance/	1.27799099
47	MP0010094_abnormal_chromosome_stability	1.26221664
48	MP0003119_abnormal_digestive_system	1.25858968
49	MP0003755_abnormal_palate_morphology	1.25594923
50	MP0003890_abnormal_embryonic-extraembry	1.24270048
51	MP0004270_analgesia	1.23450790
52	MP0002272_abnormal_nervous_system	1.22939640
53	MP0001293_anophthalmia	1.22406348
54	MP0001346_abnormal_lacrimal_gland	1.21003727
55	MP0005395_other_phenotype	1.14848512
56	MP0002638_abnormal_pupillary_reflex	1.14204030
57	MP0003937_abnormal_limbs/digits/tail_de	1.13882898
58	MP0002938_white_spotting	1.11691048
59	MP0003137_abnormal_impulse_conducting	1.09883723
60	MP0003938_abnormal_ear_development	1.06621513
61	MP0002168_other_aberrant_phenotype	1.05292811
62	MP0002282_abnormal_trachea_morphology	1.04841393
63	MP0005394_taste/olfaction_phenotype	1.02920401
64	MP0005499_abnormal_olfactory_system	1.02920401
65	MP0000647_abnormal_sebaceous_gland	1.02516840
66	MP0002090_abnormal_vision	1.00902217
67	MP0009745_abnormal_behavioral_response	1.00694278
68	MP0002572_abnormal_emotion/affect_behav	0.97373175
69	MP0003045_fibrosis	0.96361031
70	MP0002751_abnormal_autonomic_nervous	0.95419286
71	MP0003283_abnormal_digestive_organ	0.95193745
72	MP0005379_endocrine/exocrine_gland_phen	0.94997960
73	MP0002752_abnormal_somatic_nervous	0.92477278
74	MP0008057_abnormal_DNA_replication	0.92376141
75	MP0002557_abnormal_social/conspecific_i	0.92163717
76	MP0001929_abnormal_gametogenesis	0.92145920
77	MP0001286_abnormal_eye_development	0.92071794
78	MP0005195_abnormal_posterior_eye	0.91643035
79	MP0004043_abnormal_pH_regulation	0.91247468
80	MP0004085_abnormal_heartbeat	0.90286643
81	MP0003011_delayed_dark_adaptation	0.89052323
82	MP0003698_abnormal_male_reproductive	0.88903145
83	MP0002233_abnormal_nose_morphology	0.87779087
84	MP0002653_abnormal_ependyma_morphology	0.87736789
85	MP0002876_abnormal_thyroid_physiology	0.87233119
86	MP0003122_maternal_imprinting	0.85199905
87	MP0002733_abnormal_thermal_nociception	0.85082843
88	MP0006276_abnormal_autonomic_nervous	0.83907903
89	MP0009046_muscle_twitch	0.82749744
90	MP0003646_muscle_fatigue	0.82436689
91	MP0003936_abnormal_reproductive_system	0.82422382
92	MP0000383_abnormal_hair_follicle	0.82194097
93	MP0001485_abnormal_pinna_reflex	0.80716010
94	MP0001501_abnormal_sleep_pattern	0.80663231
95	MP0002063_abnormal_learning/memory/cond	0.79865330
96	MP0002734_abnormal_mechanical_nocicepti	0.79735938
97	MP0000372_irregular_coat_pigmentation	0.78234107
98	MP0000653_abnormal_sex_gland	0.77328623
99	MP0005360_urolithiasis	0.77320532
100	MP0003861_abnormal_nervous_system	0.76529242

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperinsulinemic hypoglycemia (HP:0000825)	4.54833698
2	Molar tooth sign on MRI (HP:0002419)	4.32436536
3	Abnormality of midbrain morphology (HP:0002418)	4.32436536
4	Exertional dyspnea (HP:0002875)	4.26126838
5	Colon cancer (HP:0003003)	3.72682018
6	Nephronophthisis (HP:0000090)	3.43040610
7	Ectopic kidney (HP:0000086)	3.34083967
8	Pancreatic fibrosis (HP:0100732)	3.08604000
9	Intestinal atresia (HP:0011100)	3.05911907
10	Abnormality of chromosome stability (HP:0003220)	2.95606798
11	Gonadotropin excess (HP:0000837)	2.91530935
12	Abnormality of the renal medulla (HP:0100957)	2.89786221
13	Volvulus (HP:0002580)	2.87126240
14	Pancreatic cysts (HP:0001737)	2.86699783
15	True hermaphroditism (HP:0010459)	2.84587436
16	Hematochezia (HP:0002573)	2.75223656
17	Abnormality of the labia minora (HP:0012880)	2.70942167
18	Abnormal number of incisors (HP:0011064)	2.65670384
19	Hyperventilation (HP:0002883)	2.63619263
20	Slender build (HP:0001533)	2.57397579
21	Action tremor (HP:0002345)	2.52628970
22	Tented upper lip vermilion (HP:0010804)	2.50669077
23	Optic nerve hypoplasia (HP:0000609)	2.44012134
24	Abnormality of the renal cortex (HP:0011035)	2.43977359
25	Hypothermia (HP:0002045)	2.37919441
26	Increased circulating renin level (HP:0000848)	2.27793670
27	Congenital stationary night blindness (HP:0007642)	2.26866673
28	Decreased circulating renin level (HP:0003351)	2.26716820
29	Dysdiadochokinesis (HP:0002075)	2.25935822
30	Neoplasm of the adrenal cortex (HP:0100641)	2.25652393
31	Anophthalmia (HP:0000528)	2.25644276
32	Narrow forehead (HP:0000341)	2.23274943
33	Medial flaring of the eyebrow (HP:0010747)	2.23094563
34	Abnormality of the antihelix (HP:0009738)	2.21025940
35	Microretrognathia (HP:0000308)	2.17980890
36	Lissencephaly (HP:0001339)	2.17635924
37	Asplenia (HP:0001746)	2.15328208
38	Drooling (HP:0002307)	2.12906972
39	Inappropriate behavior (HP:0000719)	2.11003133
40	Abnormality of chromosome segregation (HP:0002916)	2.10827272
41	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.10707940
42	Pachygyria (HP:0001302)	2.09167484
43	Tubular atrophy (HP:0000092)	2.07929585
44	Adactyly (HP:0009776)	2.06761373
45	Hyperactive renin-angiotensin system (HP:0000841)	2.05678486
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.02391126
47	Thickened helices (HP:0000391)	2.01773912
48	Partial agenesis of the corpus callosum (HP:0001338)	2.01417553
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99772169
50	Poor eye contact (HP:0000817)	1.97533415
51	Macroorchidism (HP:0000053)	1.96194509
52	Sloping forehead (HP:0000340)	1.94352277
53	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.94233875
54	Growth hormone deficiency (HP:0000824)	1.93196188
55	Septo-optic dysplasia (HP:0100842)	1.92195846
56	Congenital hepatic fibrosis (HP:0002612)	1.91147226
57	Fair hair (HP:0002286)	1.90705023
58	Renal cortical cysts (HP:0000803)	1.90201988
59	Cystic liver disease (HP:0006706)	1.90175779
60	Excessive salivation (HP:0003781)	1.89245066
61	Thyroiditis (HP:0100646)	1.89062545
62	Postural tremor (HP:0002174)	1.88210040
63	Oculomotor apraxia (HP:0000657)	1.87327609
64	Oligodactyly (hands) (HP:0001180)	1.86360957
65	Genital tract atresia (HP:0001827)	1.85891756
66	Aqueductal stenosis (HP:0002410)	1.83958094
67	Atonic seizures (HP:0010819)	1.81882186
68	Gastrointestinal atresia (HP:0002589)	1.81537390
69	Supernumerary spleens (HP:0009799)	1.81268396
70	Tachypnea (HP:0002789)	1.81091034
71	Cerebellar dysplasia (HP:0007033)	1.80068711
72	Chronic hepatic failure (HP:0100626)	1.77900343
73	Protruding tongue (HP:0010808)	1.76989253
74	Intellectual disability, moderate (HP:0002342)	1.76689188
75	Hypoplastic pelvis (HP:0008839)	1.74967929
76	High pitched voice (HP:0001620)	1.73097844
77	Postaxial foot polydactyly (HP:0001830)	1.71899811
78	Focal motor seizures (HP:0011153)	1.71398158
79	Gait imbalance (HP:0002141)	1.71253571
80	Anencephaly (HP:0002323)	1.70809559
81	Menstrual irregularities (HP:0000858)	1.70543189
82	Myelodysplasia (HP:0002863)	1.70379477
83	Febrile seizures (HP:0002373)	1.69094557
84	Vaginal atresia (HP:0000148)	1.68247939
85	Papilledema (HP:0001085)	1.67948756
86	Postaxial hand polydactyly (HP:0001162)	1.67786435
87	Congenital primary aphakia (HP:0007707)	1.67610902
88	Hypoplastic iliac wings (HP:0002866)	1.65719092
89	Meckel diverticulum (HP:0002245)	1.65516233
90	Abnormality of the incisor (HP:0000676)	1.65235721
91	Progressive macrocephaly (HP:0004481)	1.64622754
92	Long clavicles (HP:0000890)	1.63932814
93	Abnormality of the ileum (HP:0001549)	1.63893140
94	Exotropia (HP:0000577)	1.62904290
95	Delayed puberty (HP:0000823)	1.62653366
96	Hepatocellular necrosis (HP:0001404)	1.61734042
97	Hypochromic microcytic anemia (HP:0004840)	1.61458153
98	Methylmalonic acidemia (HP:0002912)	1.61443110
99	Hyperaldosteronism (HP:0000859)	1.60525735
100	Absent speech (HP:0001344)	1.60474141

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	6.62328355
2	PNCK	5.17799924
3	AKT3	4.10443149
4	FRK	3.83968698
5	GRK1	3.51497796
6	NLK	3.51065049
7	CDK9	2.99402284
8	WEE1	2.55451148
9	WNK3	2.42465439
10	NEK1	2.30244664
11	TTK	2.28345912
12	PLK4	2.21685591
13	MAPK13	1.92614277
14	VRK1	1.77455984
15	MKNK2	1.66917401
16	EPHA4	1.54548623
17	MUSK	1.43624265
18	EPHB2	1.42603029
19	CDC7	1.39245217
20	ERBB3	1.37814661
21	BMPR1B	1.31754395
22	PLK3	1.31591762
23	CASK	1.31006353
24	PLK2	1.30795357
25	ZAK	1.29564085
26	PRKCE	1.20347611
27	DYRK2	1.19190679
28	STK38L	1.18308874
29	PRKD3	1.16555309
30	BRAF	1.15069519
31	MAP4K2	1.14710145
32	FGFR2	1.10834566
33	CCNB1	1.06163872
34	NUAK1	1.00674629
35	EPHA3	1.00025243
36	BRSK2	0.98528492
37	PRKCG	0.94167959
38	MKNK1	0.93689215
39	ADRBK2	0.91562314
40	EIF2AK1	0.76425141
41	SGK2	0.74580923
42	PLK1	0.73719731
43	MAP3K12	0.69653144
44	CDK8	0.69105292
45	MARK1	0.67151106
46	TAF1	0.66419357
47	EIF2AK3	0.65645572
48	ACVR1B	0.63444786
49	MAP3K4	0.63192165
50	TRIM28	0.60462701
51	PAK3	0.58988340
52	ATM	0.48954094
53	VRK2	0.46983501
54	SRPK1	0.46719807
55	PINK1	0.46602192
56	BCR	0.46101999
57	CSNK1G1	0.45748266
58	INSRR	0.45322714
59	CAMK1G	0.44607346
60	STK16	0.44217475
61	CLK1	0.43695750
62	SGK223	0.40806699
63	SGK494	0.40806699
64	OXSR1	0.40718846
65	PKN1	0.40689751
66	CSNK1E	0.40651495
67	TSSK6	0.40050758
68	STK11	0.39545283
69	STK39	0.39197533
70	FER	0.38640663
71	MELK	0.38389339
72	ATR	0.36830957
73	TGFBR1	0.36517293
74	MAP2K6	0.35897723
75	BUB1	0.34393072
76	MINK1	0.33886249
77	CSNK1G2	0.32557286
78	NTRK3	0.32031538
79	NEK2	0.31514105
80	MAP2K2	0.30633494
81	MAP3K9	0.30241450
82	CSNK2A1	0.28715362
83	PASK	0.28151731
84	PRKACB	0.27600969
85	WNK4	0.26736853
86	PTK2B	0.26545439
87	CSNK1A1	0.26385182
88	CSNK2A2	0.25153965
89	PIK3CG	0.24546798
90	CSNK1G3	0.23538147
91	DYRK1A	0.23438033
92	CSNK1D	0.23297577
93	SGK3	0.23067380
94	DAPK2	0.22929406
95	MAPK15	0.22908379
96	PRKCI	0.21997044
97	CAMK2D	0.21527192
98	PRKCZ	0.20580682
99	UHMK1	0.20083225
100	ZAP70	0.19951930

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.50303792
2	Homologous recombination_Homo sapiens_hsa03440	3.06704878
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.77788002
4	Protein export_Homo sapiens_hsa03060	2.66881531
5	Fanconi anemia pathway_Homo sapiens_hsa03460	2.59949983
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.38223883
7	Mismatch repair_Homo sapiens_hsa03430	2.23557156
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.10593532
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.06674586
10	DNA replication_Homo sapiens_hsa03030	2.04534175
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.03783149
12	RNA degradation_Homo sapiens_hsa03018	2.00699100
13	Propanoate metabolism_Homo sapiens_hsa00640	2.00320400
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.92456636
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.91800523
16	Phototransduction_Homo sapiens_hsa04744	1.85916463
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.81049106
18	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.69873278
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68842886
20	Lysine degradation_Homo sapiens_hsa00310	1.66524458
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.60285033
22	Basal transcription factors_Homo sapiens_hsa03022	1.51051738
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.50166213
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.50017320
25	Nicotine addiction_Homo sapiens_hsa05033	1.44860559
26	Butanoate metabolism_Homo sapiens_hsa00650	1.40013282
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.38815679
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38680758
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.30695206
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.29465257
31	Taste transduction_Homo sapiens_hsa04742	1.25203633
32	RNA transport_Homo sapiens_hsa03013	1.23285668
33	Insulin secretion_Homo sapiens_hsa04911	1.21506445
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.20838638
35	Cocaine addiction_Homo sapiens_hsa05030	1.17767109
36	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.16394539
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11551065
38	Hippo signaling pathway_Homo sapiens_hsa04390	1.11417134
39	Tight junction_Homo sapiens_hsa04530	1.10561567
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09725998
41	RNA polymerase_Homo sapiens_hsa03020	1.04021267
42	One carbon pool by folate_Homo sapiens_hsa00670	1.03631817
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03590124
44	Olfactory transduction_Homo sapiens_hsa04740	0.97578433
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97569217
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96111040
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91164717
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.90260924
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88999917
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.87419314
51	Amphetamine addiction_Homo sapiens_hsa05031	0.86766932
52	Peroxisome_Homo sapiens_hsa04146	0.86480422
53	Retinol metabolism_Homo sapiens_hsa00830	0.84325618
54	Wnt signaling pathway_Homo sapiens_hsa04310	0.84039417
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83989360
56	Thyroid cancer_Homo sapiens_hsa05216	0.83067133
57	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.80768072
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77160277
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76304170
60	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.74672958
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73874302
62	Melanogenesis_Homo sapiens_hsa04916	0.73040523
63	Histidine metabolism_Homo sapiens_hsa00340	0.72026287
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70176006
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68766894
66	Caffeine metabolism_Homo sapiens_hsa00232	0.68756604
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.67452829
68	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.65203697
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.64306632
70	Purine metabolism_Homo sapiens_hsa00230	0.62483225
71	Serotonergic synapse_Homo sapiens_hsa04726	0.58136025
72	Oxidative phosphorylation_Homo sapiens_hsa00190	0.57477427
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53301369
74	Glutathione metabolism_Homo sapiens_hsa00480	0.52590830
75	Dopaminergic synapse_Homo sapiens_hsa04728	0.52587950
76	Circadian rhythm_Homo sapiens_hsa04710	0.52248985
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52187970
78	Fatty acid elongation_Homo sapiens_hsa00062	0.50166882
79	Circadian entrainment_Homo sapiens_hsa04713	0.49695092
80	Mineral absorption_Homo sapiens_hsa04978	0.49561301
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.47553861
82	Regulation of autophagy_Homo sapiens_hsa04140	0.45107405
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.44815828
84	Morphine addiction_Homo sapiens_hsa05032	0.43359948
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43334803
86	Base excision repair_Homo sapiens_hsa03410	0.43176194
87	Metabolic pathways_Homo sapiens_hsa01100	0.43051672
88	Salivary secretion_Homo sapiens_hsa04970	0.43046735
89	Cell cycle_Homo sapiens_hsa04110	0.42991634
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.42674522
91	Adherens junction_Homo sapiens_hsa04520	0.41929029
92	ABC transporters_Homo sapiens_hsa02010	0.41150854
93	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.40211013
94	Long-term depression_Homo sapiens_hsa04730	0.39803927
95	Parkinsons disease_Homo sapiens_hsa05012	0.37362558
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36924294
97	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36837205
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.35925247
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.35111965
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34619328

NDUFA9P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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