

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.77661993 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 7.28656893 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 7.28656893 |
| 4 | * mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.26790278 |
| 5 | * respiratory electron transport chain (GO:0022904) | 6.00826828 |
| 6 | * electron transport chain (GO:0022900) | 5.83802095 |
| 7 | DNA deamination (GO:0045006) | 5.60548361 |
| 8 | proteasome assembly (GO:0043248) | 5.56859838 |
| 9 | ribosomal small subunit biogenesis (GO:0042274) | 5.29812921 |
| 10 | viral transcription (GO:0019083) | 4.76943391 |
| 11 | regulation of mitochondrial translation (GO:0070129) | 4.70215335 |
| 12 | oxidative phosphorylation (GO:0006119) | 4.69858240 |
| 13 | translational termination (GO:0006415) | 4.64559315 |
| 14 | maturation of SSU-rRNA (GO:0030490) | 4.64119565 |
| 15 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.55039353 |
| 16 | ribosomal large subunit biogenesis (GO:0042273) | 4.50311333 |
| 17 | termination of RNA polymerase III transcription (GO:0006386) | 4.25148271 |
| 18 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.25148271 |
| 19 | ribosomal small subunit assembly (GO:0000028) | 4.23325433 |
| 20 | chaperone-mediated protein transport (GO:0072321) | 4.14415307 |
| 21 | translational elongation (GO:0006414) | 4.12676699 |
| 22 | rRNA modification (GO:0000154) | 4.11646779 |
| 23 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.04734708 |
| 24 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.04734708 |
| 25 | NADH dehydrogenase complex assembly (GO:0010257) | 4.04734708 |
| 26 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.04275743 |
| 27 | cotranslational protein targeting to membrane (GO:0006613) | 4.01961636 |
| 28 | establishment of protein localization to mitochondrion (GO:0072655) | 4.00801278 |
| 29 | protein targeting to mitochondrion (GO:0006626) | 3.98824006 |
| 30 | protein targeting to ER (GO:0045047) | 3.96864052 |
| 31 | translation (GO:0006412) | 3.95493643 |
| 32 | respiratory chain complex IV assembly (GO:0008535) | 3.93488750 |
| 33 | ATP biosynthetic process (GO:0006754) | 3.93438358 |
| 34 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.89040597 |
| 35 | protein complex biogenesis (GO:0070271) | 3.88177266 |
| 36 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.86967928 |
| 37 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.83736803 |
| 38 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.82899398 |
| 39 | translational initiation (GO:0006413) | 3.81315051 |
| 40 | protein localization to endoplasmic reticulum (GO:0070972) | 3.77682291 |
| 41 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.77682170 |
| 42 | spliceosomal snRNP assembly (GO:0000387) | 3.77261996 |
| 43 | DNA damage response, detection of DNA damage (GO:0042769) | 3.74848731 |
| 44 | GTP biosynthetic process (GO:0006183) | 3.73648434 |
| 45 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.73577551 |
| 46 | ribosome assembly (GO:0042255) | 3.72593346 |
| 47 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.72317360 |
| 48 | protein localization to mitochondrion (GO:0070585) | 3.69438155 |
| 49 | cellular protein complex disassembly (GO:0043624) | 3.69354698 |
| 50 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.67868638 |
| 51 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.67063285 |
| 52 | cytochrome complex assembly (GO:0017004) | 3.65587231 |
| 53 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.65160735 |
| 54 | 7-methylguanosine mRNA capping (GO:0006370) | 3.64022324 |
| 55 | cellular component biogenesis (GO:0044085) | 3.61359206 |
| 56 | chromatin remodeling at centromere (GO:0031055) | 3.60368632 |
| 57 | viral life cycle (GO:0019058) | 3.58333949 |
| 58 | RNA capping (GO:0036260) | 3.57062161 |
| 59 | 7-methylguanosine RNA capping (GO:0009452) | 3.57062161 |
| 60 | CENP-A containing nucleosome assembly (GO:0034080) | 3.55072118 |
| 61 | ubiquinone biosynthetic process (GO:0006744) | 3.54023858 |
| 62 | quinone biosynthetic process (GO:1901663) | 3.54023858 |
| 63 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.53531076 |
| 64 | establishment of integrated proviral latency (GO:0075713) | 3.53341388 |
| 65 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.52354270 |
| 66 | spliceosomal complex assembly (GO:0000245) | 3.51774357 |
| 67 | negative regulation of ligase activity (GO:0051352) | 3.51307487 |
| 68 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.51307487 |
| 69 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.50253583 |
| 70 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.49886513 |
| 71 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.49004834 |
| 72 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.48421005 |
| 73 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.46321387 |
| 74 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 3.43585585 |
| 75 | pseudouridine synthesis (GO:0001522) | 3.41974775 |
| 76 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.38649690 |
| 77 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.38562083 |
| 78 | inner mitochondrial membrane organization (GO:0007007) | 3.38165928 |
| 79 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.36959039 |
| 80 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.35938268 |
| 81 | metallo-sulfur cluster assembly (GO:0031163) | 3.35930980 |
| 82 | iron-sulfur cluster assembly (GO:0016226) | 3.35930980 |
| 83 | protein neddylation (GO:0045116) | 3.35648377 |
| 84 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.35079268 |
| 85 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.35079268 |
| 86 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.35079268 |
| 87 | regulation of cellular respiration (GO:0043457) | 3.35044799 |
| 88 | protein deneddylation (GO:0000338) | 3.34944210 |
| 89 | rRNA processing (GO:0006364) | 3.34378821 |
| 90 | peptidyl-histidine modification (GO:0018202) | 3.32184269 |
| 91 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.31909856 |
| 92 | UTP biosynthetic process (GO:0006228) | 3.31633558 |
| 93 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.29975784 |
| 94 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.29975784 |
| 95 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.28633550 |
| 96 | L-methionine salvage (GO:0071267) | 3.28574577 |
| 97 | L-methionine biosynthetic process (GO:0071265) | 3.28574577 |
| 98 | amino acid salvage (GO:0043102) | 3.28574577 |
| 99 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.26797551 |
| 100 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.26797551 |
| 101 | DNA replication checkpoint (GO:0000076) | 3.26268575 |
| 102 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.25933152 |
| 103 | hydrogen ion transmembrane transport (GO:1902600) | 3.25910057 |
| 104 | mitochondrial transport (GO:0006839) | 3.25707604 |
| 105 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.24948392 |
| 106 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.24414512 |
| 107 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.24414512 |
| 108 | positive regulation of ligase activity (GO:0051351) | 3.24005385 |
| 109 | rRNA metabolic process (GO:0016072) | 3.23175470 |
| 110 | cullin deneddylation (GO:0010388) | 3.22845970 |
| 111 | aerobic respiration (GO:0009060) | 3.22457413 |
| 112 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.20354830 |
| 113 | formation of translation preinitiation complex (GO:0001731) | 3.14400370 |
| 114 | protein complex disassembly (GO:0043241) | 3.14087150 |
| 115 | intracellular protein transmembrane import (GO:0044743) | 3.13610808 |
| 116 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.09539759 |
| 117 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.07809640 |
| 118 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.07809640 |
| 119 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.06348306 |
| 120 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.05532981 |
| 121 | protein targeting to membrane (GO:0006612) | 3.04864330 |
| 122 | macromolecular complex disassembly (GO:0032984) | 3.04778679 |
| 123 | proton transport (GO:0015992) | 3.03440726 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.05879844 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.56481090 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.30529951 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.08873915 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.08414178 |
| 6 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.89500359 |
| 7 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.71665477 |
| 8 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.52181111 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.46911499 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.42705779 |
| 11 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.40323552 |
| 12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.29509420 |
| 13 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.25101821 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.24424236 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.23287229 |
| 16 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.00046147 |
| 17 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.97988695 |
| 18 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.95069496 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.92039902 |
| 20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.47261230 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.47116637 |
| 22 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.45780445 |
| 23 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.42723083 |
| 24 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.34059964 |
| 25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.33473083 |
| 26 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.28959972 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.28381751 |
| 28 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.25497081 |
| 29 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.22262493 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.08843113 |
| 31 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.08225411 |
| 32 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.02615725 |
| 33 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 2.01287357 |
| 34 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.94502078 |
| 35 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.85265723 |
| 36 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.83126748 |
| 37 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.79747032 |
| 38 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.75734922 |
| 39 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.67334481 |
| 40 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.65398142 |
| 41 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.65301332 |
| 42 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.64175120 |
| 43 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.62588544 |
| 44 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.58195688 |
| 45 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.58157684 |
| 46 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.55738307 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.55644110 |
| 48 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.54936413 |
| 49 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.53158693 |
| 50 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.46793455 |
| 51 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.42969618 |
| 52 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.39866173 |
| 53 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.39522936 |
| 54 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.38092785 |
| 55 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.34549178 |
| 56 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.33561310 |
| 57 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.27654249 |
| 58 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.27401549 |
| 59 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.24874024 |
| 60 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.24548774 |
| 61 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.23887175 |
| 62 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.22092266 |
| 63 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.15944224 |
| 64 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15932068 |
| 65 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.15701940 |
| 66 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.14993012 |
| 67 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.11977693 |
| 68 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.10663325 |
| 69 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.09554084 |
| 70 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08128552 |
| 71 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.06026279 |
| 72 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.05191224 |
| 73 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.05016392 |
| 74 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.98608752 |
| 75 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.97580298 |
| 76 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.96261413 |
| 77 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.94130141 |
| 78 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.93211430 |
| 79 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.92509510 |
| 80 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.92416642 |
| 81 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.91539269 |
| 82 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.91030054 |
| 83 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.90757835 |
| 84 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.90038333 |
| 85 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89564227 |
| 86 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.89426654 |
| 87 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.87704625 |
| 88 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.84058555 |
| 89 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.83986985 |
| 90 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.83862660 |
| 91 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.83798754 |
| 92 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.83602778 |
| 93 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.83558535 |
| 94 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.82814383 |
| 95 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.82210830 |
| 96 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.79890266 |
| 97 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.79516113 |
| 98 | * HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.78810130 |
| 99 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.77545791 |
| 100 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.76775930 |
| 101 | VDR_22108803_ChIP-Seq_LS180_Human | 0.76614664 |
| 102 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.76413532 |
| 103 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.75859039 |
| 104 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.75830388 |
| 105 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.75678398 |
| 106 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.74559113 |
| 107 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.73673358 |
| 108 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.72862446 |
| 109 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.72567944 |
| 110 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.72567944 |
| 111 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.72567944 |
| 112 | * TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.71972058 |
| 113 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.71740484 |
| 114 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.68926504 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003646_muscle_fatigue | 4.10421771 |
| 2 | MP0009379_abnormal_foot_pigmentation | 3.51466658 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.50010521 |
| 4 | MP0002837_dystrophic_cardiac_calcinosis | 3.09790772 |
| 5 | MP0006036_abnormal_mitochondrial_physio | 3.08149442 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 2.87543359 |
| 7 | MP0004215_abnormal_myocardial_fiber | 2.70467256 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 2.68462717 |
| 9 | MP0006035_abnormal_mitochondrial_morpho | 2.62064523 |
| 10 | MP0004084_abnormal_cardiac_muscle | 2.59138861 |
| 11 | MP0001529_abnormal_vocalization | 2.44223675 |
| 12 | MP0003111_abnormal_nucleus_morphology | 2.40660670 |
| 13 | MP0003718_maternal_effect | 2.40448786 |
| 14 | MP0005330_cardiomyopathy | 2.29583957 |
| 15 | MP0000749_muscle_degeneration | 2.28893706 |
| 16 | MP0008932_abnormal_embryonic_tissue | 2.27715384 |
| 17 | MP0004145_abnormal_muscle_electrophysio | 2.19212290 |
| 18 | MP0008058_abnormal_DNA_repair | 2.12491892 |
| 19 | MP0000751_myopathy | 2.07263972 |
| 20 | MP0003077_abnormal_cell_cycle | 2.06508941 |
| 21 | MP0003137_abnormal_impulse_conducting | 1.95187535 |
| 22 | MP0010094_abnormal_chromosome_stability | 1.93402692 |
| 23 | MP0001986_abnormal_taste_sensitivity | 1.92020756 |
| 24 | MP0003136_yellow_coat_color | 1.87210824 |
| 25 | MP0008057_abnormal_DNA_replication | 1.86070323 |
| 26 | MP0003186_abnormal_redox_activity | 1.85770061 |
| 27 | MP0004036_abnormal_muscle_relaxation | 1.84688808 |
| 28 | MP0008877_abnormal_DNA_methylation | 1.81908281 |
| 29 | MP0000750_abnormal_muscle_regeneration | 1.80420197 |
| 30 | MP0009697_abnormal_copulation | 1.72656820 |
| 31 | MP0008789_abnormal_olfactory_epithelium | 1.67899762 |
| 32 | MP0005423_abnormal_somatic_nervous | 1.64596831 |
| 33 | MP0000566_synostosis | 1.56662922 |
| 34 | MP0002332_abnormal_exercise_endurance | 1.55903183 |
| 35 | MP0003786_premature_aging | 1.54596778 |
| 36 | MP0003315_abnormal_perineum_morphology | 1.53685281 |
| 37 | MP0006276_abnormal_autonomic_nervous | 1.52462309 |
| 38 | MP0003123_paternal_imprinting | 1.51654188 |
| 39 | MP0004142_abnormal_muscle_tone | 1.50370601 |
| 40 | MP0004133_heterotaxia | 1.48784405 |
| 41 | MP0001905_abnormal_dopamine_level | 1.47833846 |
| 42 | MP0002736_abnormal_nociception_after | 1.42901119 |
| 43 | MP0003011_delayed_dark_adaptation | 1.41910586 |
| 44 | MP0002269_muscular_atrophy | 1.41562915 |
| 45 | MP0005266_abnormal_metabolism | 1.41014353 |
| 46 | MP0003221_abnormal_cardiomyocyte_apopto | 1.40462785 |
| 47 | MP0002972_abnormal_cardiac_muscle | 1.34870178 |
| 48 | MP0005670_abnormal_white_adipose | 1.32779902 |
| 49 | MP0002160_abnormal_reproductive_system | 1.31759906 |
| 50 | MP0005620_abnormal_muscle_contractility | 1.28803384 |
| 51 | MP0008995_early_reproductive_senescence | 1.28094868 |
| 52 | MP0002638_abnormal_pupillary_reflex | 1.26604303 |
| 53 | MP0002106_abnormal_muscle_physiology | 1.26127345 |
| 54 | MP0003567_abnormal_fetal_cardiomyocyte | 1.26118245 |
| 55 | MP0008875_abnormal_xenobiotic_pharmacok | 1.24950122 |
| 56 | MP0001984_abnormal_olfaction | 1.22772437 |
| 57 | MP0001293_anophthalmia | 1.22449687 |
| 58 | MP0006292_abnormal_olfactory_placode | 1.21527050 |
| 59 | MP0005394_taste/olfaction_phenotype | 1.20644371 |
| 60 | MP0005499_abnormal_olfactory_system | 1.20644371 |
| 61 | MP0005084_abnormal_gallbladder_morpholo | 1.16945003 |
| 62 | MP0005379_endocrine/exocrine_gland_phen | 1.16624788 |
| 63 | MP0001544_abnormal_cardiovascular_syste | 1.16383209 |
| 64 | MP0005385_cardiovascular_system_phenoty | 1.16383209 |
| 65 | MP0009046_muscle_twitch | 1.16328741 |
| 66 | MP0001188_hyperpigmentation | 1.16053327 |
| 67 | MP0010030_abnormal_orbit_morphology | 1.15510510 |
| 68 | MP0003941_abnormal_skin_development | 1.14216399 |
| 69 | MP0002234_abnormal_pharynx_morphology | 1.14039201 |
| 70 | MP0003121_genomic_imprinting | 1.13602395 |
| 71 | MP0001853_heart_inflammation | 1.12954906 |
| 72 | MP0004484_altered_response_of | 1.12851923 |
| 73 | MP0003195_calcinosis | 1.10290679 |
| 74 | MP0002102_abnormal_ear_morphology | 1.10118394 |
| 75 | MP0008775_abnormal_heart_ventricle | 1.09296052 |
| 76 | MP0002127_abnormal_cardiovascular_syste | 1.09097647 |
| 77 | MP0001727_abnormal_embryo_implantation | 1.08381112 |
| 78 | MP0003880_abnormal_central_pattern | 1.07822229 |
| 79 | MP0004087_abnormal_muscle_fiber | 1.07052452 |
| 80 | MP0004147_increased_porphyrin_level | 1.06329779 |
| 81 | MP0008007_abnormal_cellular_replicative | 1.02905364 |
| 82 | MP0002090_abnormal_vision | 1.02349112 |
| 83 | MP0005646_abnormal_pituitary_gland | 1.02234009 |
| 84 | MP0004043_abnormal_pH_regulation | 0.98446602 |
| 85 | MP0003950_abnormal_plasma_membrane | 0.98155417 |
| 86 | MP0002210_abnormal_sex_determination | 0.96941763 |
| 87 | MP0005377_hearing/vestibular/ear_phenot | 0.96618526 |
| 88 | MP0003878_abnormal_ear_physiology | 0.96618526 |
| 89 | MP0005369_muscle_phenotype | 0.96357504 |
| 90 | MP0005332_abnormal_amino_acid | 0.96173668 |
| 91 | MP0008872_abnormal_physiological_respon | 0.95532300 |
| 92 | MP0005636_abnormal_mineral_homeostasis | 0.95324342 |
| 93 | MP0005389_reproductive_system_phenotype | 0.95194300 |
| 94 | MP0002132_abnormal_respiratory_system | 0.92485320 |
| 95 | MP0002277_abnormal_respiratory_mucosa | 0.92072867 |
| 96 | MP0000631_abnormal_neuroendocrine_gland | 0.91766642 |
| 97 | MP0005408_hypopigmentation | 0.91579792 |
| 98 | MP0001764_abnormal_homeostasis | 0.91079382 |
| 99 | MP0000358_abnormal_cell_content/ | 0.90988312 |
| 100 | MP0000759_abnormal_skeletal_muscle | 0.90292352 |
| 101 | MP0006138_congestive_heart_failure | 0.89474312 |
| 102 | MP0001968_abnormal_touch/_nociception | 0.88606435 |
| 103 | MP0005551_abnormal_eye_electrophysiolog | 0.88225444 |
| 104 | MP0001485_abnormal_pinna_reflex | 0.88001451 |
| 105 | MP0005253_abnormal_eye_physiology | 0.87832775 |
| 106 | MP0004085_abnormal_heartbeat | 0.87375511 |
| 107 | MP0000049_abnormal_middle_ear | 0.86689993 |
| 108 | MP0001730_embryonic_growth_arrest | 0.86589466 |
| 109 | MP0000747_muscle_weakness | 0.85204832 |
| 110 | MP0005165_increased_susceptibility_to | 0.84166125 |
| 111 | MP0005451_abnormal_body_composition | 0.83928959 |
| 112 | MP0000350_abnormal_cell_proliferation | 0.81227159 |
| 113 | MP0003937_abnormal_limbs/digits/tail_de | 0.79844956 |
| 114 | MP0001145_abnormal_male_reproductive | 0.79643215 |
| 115 | MP0010630_abnormal_cardiac_muscle | 0.77805930 |
| 116 | MP0005395_other_phenotype | 0.76259939 |
| 117 | MP0005409_darkened_coat_color | 0.76000679 |
| 118 | MP0006072_abnormal_retinal_apoptosis | 0.75829061 |
| 119 | MP0003828_pulmonary_edema | 0.74536892 |
| 120 | MP0002938_white_spotting | 0.72534706 |
| 121 | MP0005645_abnormal_hypothalamus_physiol | 0.70790302 |
| 122 | MP0004381_abnormal_hair_follicle | 0.69933357 |
| 123 | MP0002751_abnormal_autonomic_nervous | 0.69926512 |
| 124 | MP0000653_abnormal_sex_gland | 0.69603776 |
| 125 | MP0002233_abnormal_nose_morphology | 0.69265414 |
| 126 | MP0000313_abnormal_cell_death | 0.68833452 |
| 127 | MP0002272_abnormal_nervous_system | 0.68577693 |
| 128 | MP0005075_abnormal_melanosome_morpholog | 0.67856350 |
| 129 | MP0001929_abnormal_gametogenesis | 0.67452327 |
| 130 | MP0005376_homeostasis/metabolism_phenot | 0.66507729 |
| 131 | MP0003122_maternal_imprinting | 0.66370438 |
| 132 | MP0009745_abnormal_behavioral_response | 0.66042560 |
| 133 | MP0002163_abnormal_gland_morphology | 0.65320450 |
| 134 | MP0000372_irregular_coat_pigmentation | 0.65207336 |
| 135 | MP0001697_abnormal_embryo_size | 0.65013612 |
| 136 | MP0003938_abnormal_ear_development | 0.64027894 |
| 137 | MP0003119_abnormal_digestive_system | 0.63320396 |
| 138 | MP0001672_abnormal_embryogenesis/_devel | 0.61692319 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.31255163 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.80298444 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.61312564 |
| 4 | Acute encephalopathy (HP:0006846) | 5.31296602 |
| 5 | Hepatocellular necrosis (HP:0001404) | 5.23571795 |
| 6 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 5.16724244 |
| 7 | Progressive macrocephaly (HP:0004481) | 5.11508574 |
| 8 | Hepatic necrosis (HP:0002605) | 5.08369452 |
| 9 | Increased CSF lactate (HP:0002490) | 5.03740526 |
| 10 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.89684482 |
| 11 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.85039737 |
| 12 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.85039737 |
| 13 | Progressive external ophthalmoplegia (HP:0000590) | 4.55431220 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 4.46802525 |
| 15 | Exercise intolerance (HP:0003546) | 4.26724423 |
| 16 | Lipid accumulation in hepatocytes (HP:0006561) | 4.21950366 |
| 17 | Increased serum lactate (HP:0002151) | 4.14105690 |
| 18 | Increased intramyocellular lipid droplets (HP:0012240) | 4.12281600 |
| 19 | Cerebral edema (HP:0002181) | 4.09401948 |
| 20 | Lactic acidosis (HP:0003128) | 3.98568344 |
| 21 | Increased muscle lipid content (HP:0009058) | 3.76974472 |
| 22 | Respiratory failure (HP:0002878) | 3.72375948 |
| 23 | Renal Fanconi syndrome (HP:0001994) | 3.70011626 |
| 24 | Abnormality of glycolysis (HP:0004366) | 3.62749217 |
| 25 | Increased serum pyruvate (HP:0003542) | 3.62749217 |
| 26 | 3-Methylglutaconic aciduria (HP:0003535) | 3.62692671 |
| 27 | Breast hypoplasia (HP:0003187) | 3.44919674 |
| 28 | Reticulocytopenia (HP:0001896) | 3.39365382 |
| 29 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.32480699 |
| 30 | Abnormal number of erythroid precursors (HP:0012131) | 3.22898482 |
| 31 | Optic disc pallor (HP:0000543) | 3.20148617 |
| 32 | Macrocytic anemia (HP:0001972) | 3.08254841 |
| 33 | Duplicated collecting system (HP:0000081) | 3.00426089 |
| 34 | Exertional dyspnea (HP:0002875) | 2.98384652 |
| 35 | Leukodystrophy (HP:0002415) | 2.96050208 |
| 36 | Proximal tubulopathy (HP:0000114) | 2.91755642 |
| 37 | Respiratory difficulties (HP:0002880) | 2.74585942 |
| 38 | Progressive muscle weakness (HP:0003323) | 2.71875088 |
| 39 | Type I transferrin isoform profile (HP:0003642) | 2.70273905 |
| 40 | Birth length less than 3rd percentile (HP:0003561) | 2.70071131 |
| 41 | CNS demyelination (HP:0007305) | 2.69700491 |
| 42 | Palpitations (HP:0001962) | 2.68427361 |
| 43 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.66672347 |
| 44 | Abnormality of alanine metabolism (HP:0010916) | 2.66672347 |
| 45 | Hyperalaninemia (HP:0003348) | 2.66672347 |
| 46 | Rhabdomyolysis (HP:0003201) | 2.63803081 |
| 47 | Cerebral hypomyelination (HP:0006808) | 2.62723788 |
| 48 | Lethargy (HP:0001254) | 2.58092748 |
| 49 | Hyperglycinemia (HP:0002154) | 2.56232752 |
| 50 | Microvesicular hepatic steatosis (HP:0001414) | 2.51769921 |
| 51 | Abnormality of the renal collecting system (HP:0004742) | 2.47123259 |
| 52 | Sudden death (HP:0001699) | 2.44977363 |
| 53 | Dicarboxylic aciduria (HP:0003215) | 2.41930106 |
| 54 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.41930106 |
| 55 | External ophthalmoplegia (HP:0000544) | 2.41679176 |
| 56 | Emotional lability (HP:0000712) | 2.39565776 |
| 57 | Abnormality of renal resorption (HP:0011038) | 2.33901183 |
| 58 | Carpal bone hypoplasia (HP:0001498) | 2.32497639 |
| 59 | Pallor (HP:0000980) | 2.30962447 |
| 60 | Nausea (HP:0002018) | 2.28880314 |
| 61 | Abnormality of urine glucose concentration (HP:0011016) | 2.26354122 |
| 62 | Glycosuria (HP:0003076) | 2.26354122 |
| 63 | Methylmalonic acidemia (HP:0002912) | 2.22603875 |
| 64 | Myoglobinuria (HP:0002913) | 2.21778124 |
| 65 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.21228250 |
| 66 | Aplastic anemia (HP:0001915) | 2.16554986 |
| 67 | Abnormality of the anterior horn cell (HP:0006802) | 2.13850620 |
| 68 | Degeneration of anterior horn cells (HP:0002398) | 2.13850620 |
| 69 | Oral leukoplakia (HP:0002745) | 2.10244475 |
| 70 | Ventricular tachycardia (HP:0004756) | 2.09871844 |
| 71 | Abnormality of serum amino acid levels (HP:0003112) | 2.07677568 |
| 72 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.06812680 |
| 73 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.06812680 |
| 74 | Abnormal protein glycosylation (HP:0012346) | 2.06812680 |
| 75 | Abnormal glycosylation (HP:0012345) | 2.06812680 |
| 76 | Testicular atrophy (HP:0000029) | 2.06088579 |
| 77 | Colon cancer (HP:0003003) | 2.04698205 |
| 78 | Hyperphosphaturia (HP:0003109) | 2.01458820 |
| 79 | Muscle hypertrophy of the lower extremities (HP:0008968) | 2.01110525 |
| 80 | Calf muscle hypertrophy (HP:0008981) | 1.99063366 |
| 81 | Unsteady gait (HP:0002317) | 1.98416073 |
| 82 | Generalized aminoaciduria (HP:0002909) | 1.97723419 |
| 83 | Reduced antithrombin III activity (HP:0001976) | 1.97158864 |
| 84 | Pancytopenia (HP:0001876) | 1.96437555 |
| 85 | Myokymia (HP:0002411) | 1.91761446 |
| 86 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.89913566 |
| 87 | Methylmalonic aciduria (HP:0012120) | 1.89207207 |
| 88 | Absent thumb (HP:0009777) | 1.84848418 |
| 89 | Multiple enchondromatosis (HP:0005701) | 1.84777682 |
| 90 | Gout (HP:0001997) | 1.84245893 |
| 91 | X-linked dominant inheritance (HP:0001423) | 1.83837998 |
| 92 | Rough bone trabeculation (HP:0100670) | 1.83472918 |
| 93 | Abnormality of glycine metabolism (HP:0010895) | 1.82352170 |
| 94 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.82352170 |
| 95 | Secondary amenorrhea (HP:0000869) | 1.81431197 |
| 96 | Abnormality of methionine metabolism (HP:0010901) | 1.79794645 |
| 97 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.78365232 |
| 98 | Abnormality of the labia minora (HP:0012880) | 1.78348612 |
| 99 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.78336232 |
| 100 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.76505071 |
| 101 | Cleft eyelid (HP:0000625) | 1.75305488 |
| 102 | Muscle fiber splitting (HP:0003555) | 1.74990078 |
| 103 | Hypoglycemic coma (HP:0001325) | 1.74947749 |
| 104 | Meckel diverticulum (HP:0002245) | 1.73367203 |
| 105 | Congenital, generalized hypertrichosis (HP:0004540) | 1.72182644 |
| 106 | Gliosis (HP:0002171) | 1.70929504 |
| 107 | Ureteral duplication (HP:0000073) | 1.69164540 |
| 108 | Hyperglycinuria (HP:0003108) | 1.69086537 |
| 109 | Transposition of the great arteries (HP:0001669) | 1.68707512 |
| 110 | Abnormal connection of the cardiac segments (HP:0011545) | 1.68707512 |
| 111 | Abnormal ventriculo-arterial connection (HP:0011563) | 1.68707512 |
| 112 | Absent radius (HP:0003974) | 1.66724943 |
| 113 | Lipoatrophy (HP:0100578) | 1.65951990 |
| 114 | Microretrognathia (HP:0000308) | 1.65770399 |
| 115 | Abnormality of the ileum (HP:0001549) | 1.65642861 |
| 116 | Neuroendocrine neoplasm (HP:0100634) | 1.65027326 |
| 117 | Abnormal urine phosphate concentration (HP:0012599) | 1.64918920 |
| 118 | Vomiting (HP:0002013) | 1.64491135 |
| 119 | Abnormality of placental membranes (HP:0011409) | 1.63995176 |
| 120 | Amniotic constriction ring (HP:0009775) | 1.63995176 |
| 121 | Neoplasm of the adrenal gland (HP:0100631) | 1.63484190 |
| 122 | Sparse eyelashes (HP:0000653) | 1.63191598 |
| 123 | Acute lymphatic leukemia (HP:0006721) | 1.63153133 |
| 124 | Ragged-red muscle fibers (HP:0003200) | 1.62748350 |
| 125 | Poor suck (HP:0002033) | 1.62540313 |
| 126 | Blindness (HP:0000618) | 1.60777489 |
| 127 | Megaloblastic anemia (HP:0001889) | 1.60416149 |
| 128 | Pulmonary artery stenosis (HP:0004415) | 1.59872721 |
| 129 | Aplasia involving forearm bones (HP:0009822) | 1.58658048 |
| 130 | Triphalangeal thumb (HP:0001199) | 1.58471040 |
| 131 | Horseshoe kidney (HP:0000085) | 1.57488311 |
| 132 | Pancreatic fibrosis (HP:0100732) | 1.54325182 |
| 133 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.53744564 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.56651386 |
| 2 | IRAK3 | 4.49796723 |
| 3 | VRK2 | 4.40991920 |
| 4 | STK16 | 4.24004047 |
| 5 | PLK4 | 3.80543415 |
| 6 | ZAK | 3.14554711 |
| 7 | WEE1 | 3.10595235 |
| 8 | EIF2AK1 | 3.10373692 |
| 9 | MARK1 | 2.85919412 |
| 10 | TLK1 | 2.66524226 |
| 11 | NME2 | 2.43298178 |
| 12 | NME1 | 2.32095268 |
| 13 | SRPK1 | 2.21990327 |
| 14 | IRAK2 | 2.10261142 |
| 15 | BCKDK | 2.07807346 |
| 16 | VRK1 | 1.88191993 |
| 17 | PNCK | 1.80639942 |
| 18 | TESK2 | 1.79573792 |
| 19 | IRAK4 | 1.76080604 |
| 20 | TTK | 1.71089189 |
| 21 | EIF2AK3 | 1.69490234 |
| 22 | OBSCN | 1.61188607 |
| 23 | IRAK1 | 1.60090872 |
| 24 | MYLK | 1.50988828 |
| 25 | NUAK1 | 1.47570083 |
| 26 | PBK | 1.35251311 |
| 27 | EPHA2 | 1.34400275 |
| 28 | KDR | 1.30637389 |
| 29 | TRIM28 | 1.25643522 |
| 30 | NEK1 | 1.22952175 |
| 31 | MAP4K2 | 1.19987958 |
| 32 | STK38L | 1.16482812 |
| 33 | CDC7 | 1.16107538 |
| 34 | MUSK | 1.14619149 |
| 35 | PLK1 | 1.13277362 |
| 36 | CSNK1G3 | 1.12382777 |
| 37 | DYRK3 | 1.09431676 |
| 38 | LIMK1 | 1.06853263 |
| 39 | BRAF | 1.06558715 |
| 40 | ABL2 | 1.01141317 |
| 41 | AURKA | 1.00470952 |
| 42 | ARAF | 0.95921201 |
| 43 | CSNK1G2 | 0.95314291 |
| 44 | DYRK2 | 0.94404997 |
| 45 | CSNK1G1 | 0.92867476 |
| 46 | CDC42BPA | 0.92290921 |
| 47 | TSSK6 | 0.92214629 |
| 48 | BRSK2 | 0.88871450 |
| 49 | PINK1 | 0.88285197 |
| 50 | TAF1 | 0.87613530 |
| 51 | CAMK2D | 0.87244040 |
| 52 | PLK3 | 0.85723334 |
| 53 | GRK7 | 0.84783595 |
| 54 | MAP3K11 | 0.83851457 |
| 55 | LATS2 | 0.83378700 |
| 56 | BMPR1B | 0.81152160 |
| 57 | ACVR1B | 0.80755760 |
| 58 | PRKCI | 0.80336667 |
| 59 | PDK4 | 0.79361455 |
| 60 | PDK3 | 0.79361455 |
| 61 | MAPKAPK3 | 0.77925511 |
| 62 | SCYL2 | 0.77023988 |
| 63 | CSNK1A1L | 0.76829680 |
| 64 | AURKB | 0.75074525 |
| 65 | DAPK1 | 0.74473482 |
| 66 | CAMK2G | 0.72482437 |
| 67 | PHKG1 | 0.72346803 |
| 68 | PHKG2 | 0.72346803 |
| 69 | EIF2AK2 | 0.72343453 |
| 70 | GRK1 | 0.71755930 |
| 71 | LMTK2 | 0.71223454 |
| 72 | TESK1 | 0.65069612 |
| 73 | CAMK2B | 0.64841995 |
| 74 | STK39 | 0.63671679 |
| 75 | INSRR | 0.63256987 |
| 76 | MKNK1 | 0.62985914 |
| 77 | RPS6KB2 | 0.61796314 |
| 78 | MAP2K7 | 0.61569000 |
| 79 | PIM2 | 0.61077861 |
| 80 | WNK4 | 0.59559572 |
| 81 | CSNK2A1 | 0.59403981 |
| 82 | RPS6KA5 | 0.58144418 |
| 83 | ATR | 0.56662494 |
| 84 | LRRK2 | 0.56502410 |
| 85 | DAPK3 | 0.55194797 |
| 86 | CHEK2 | 0.53997320 |
| 87 | STK4 | 0.53455168 |
| 88 | CSNK2A2 | 0.53402770 |
| 89 | MKNK2 | 0.51905825 |
| 90 | MST4 | 0.50411309 |
| 91 | STK24 | 0.49870535 |
| 92 | ROCK2 | 0.49270195 |
| 93 | BRSK1 | 0.48900753 |
| 94 | PRKCG | 0.47530921 |
| 95 | CDK19 | 0.47148477 |
| 96 | PAK1 | 0.46393027 |
| 97 | PAK4 | 0.44295976 |
| 98 | PASK | 0.43749713 |
| 99 | RPS6KA4 | 0.43673557 |
| 100 | PDK2 | 0.43595763 |
| 101 | ILK | 0.43359211 |
| 102 | ATM | 0.43213773 |
| 103 | CDK7 | 0.41307946 |
| 104 | BCR | 0.40883130 |
| 105 | MAP3K4 | 0.40749239 |
| 106 | MINK1 | 0.39962527 |
| 107 | MAPKAPK5 | 0.39801682 |
| 108 | MAP3K8 | 0.38651085 |
| 109 | PIK3CA | 0.37681160 |
| 110 | MAP3K12 | 0.36443468 |
| 111 | AKT2 | 0.35991078 |
| 112 | CSNK1A1 | 0.35843664 |
| 113 | CAMK2A | 0.34381602 |
| 114 | TNIK | 0.31902010 |
| 115 | CSNK1E | 0.31027589 |
| 116 | AKT3 | 0.30786621 |
| 117 | WNK3 | 0.30615229 |
| 118 | CHEK1 | 0.29155864 |
| 119 | OXSR1 | 0.28993545 |
| 120 | CDK14 | 0.28650726 |
| 121 | CDK8 | 0.28126109 |
| 122 | CCNB1 | 0.28100543 |
| 123 | ADRBK2 | 0.25473538 |
| 124 | PLK2 | 0.24989885 |
| 125 | ROCK1 | 0.24880956 |
| 126 | MAPK4 | 0.23714554 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.82478084 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.57230552 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.37903459 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 4.05739655 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.50291282 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.35733212 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 3.02068933 |
| 8 | DNA replication_Homo sapiens_hsa03030 | 2.93306525 |
| 9 | * Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.69054224 |
| 10 | Mismatch repair_Homo sapiens_hsa03430 | 2.55636475 |
| 11 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.55385493 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.47123620 |
| 13 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.23962101 |
| 14 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.21022814 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 2.17439634 |
| 16 | Homologous recombination_Homo sapiens_hsa03440 | 2.05121065 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.85025460 |
| 18 | Protein export_Homo sapiens_hsa03060 | 1.59326474 |
| 19 | RNA transport_Homo sapiens_hsa03013 | 1.55533966 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.54395094 |
| 21 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.50549598 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.45401667 |
| 23 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.42384564 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.42077100 |
| 25 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.39276082 |
| 26 | Base excision repair_Homo sapiens_hsa03410 | 1.37887658 |
| 27 | Basal transcription factors_Homo sapiens_hsa03022 | 1.36698224 |
| 28 | Carbon metabolism_Homo sapiens_hsa01200 | 1.27389429 |
| 29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.24861779 |
| 30 | RNA degradation_Homo sapiens_hsa03018 | 1.23954032 |
| 31 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.20767080 |
| 32 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.11668961 |
| 33 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.11127013 |
| 34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.09257261 |
| 35 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.05700082 |
| 36 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.04751182 |
| 37 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.03200703 |
| 38 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.00614169 |
| 39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.95450776 |
| 40 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.93242871 |
| 41 | Cell cycle_Homo sapiens_hsa04110 | 0.93090305 |
| 42 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.90943868 |
| 43 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.85339387 |
| 44 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.85305216 |
| 45 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.82830537 |
| 46 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.81634801 |
| 47 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.77550557 |
| 48 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.75108630 |
| 49 | Sulfur relay system_Homo sapiens_hsa04122 | 0.73644411 |
| 50 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.72471630 |
| 51 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.71705500 |
| 52 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.70893043 |
| 53 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.66112035 |
| 54 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.65248958 |
| 55 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.65014906 |
| 56 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.62164124 |
| 57 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.61146959 |
| 58 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.61067501 |
| 59 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.59917155 |
| 60 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.59210169 |
| 61 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.57981763 |
| 62 | Peroxisome_Homo sapiens_hsa04146 | 0.56459935 |
| 63 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.56399648 |
| 64 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.55862090 |
| 65 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.53577586 |
| 66 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.51338248 |
| 67 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.50615283 |
| 68 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.50585031 |
| 69 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.43536287 |
| 70 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.41812800 |
| 71 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.41306157 |
| 72 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.39355100 |
| 73 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.37821819 |
| 74 | Phototransduction_Homo sapiens_hsa04744 | 0.37686367 |
| 75 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.35279659 |
| 76 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.34154818 |
| 77 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.33601844 |
| 78 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.33329866 |
| 79 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.33029461 |
| 80 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.32522697 |
| 81 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.30615189 |
| 82 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.30536091 |
| 83 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.30240315 |
| 84 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.30162929 |
| 85 | Galactose metabolism_Homo sapiens_hsa00052 | 0.29887363 |
| 86 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.27673565 |
| 87 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.26843518 |
| 88 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.25487881 |
| 89 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.25326107 |
| 90 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.24075642 |
| 91 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.23854583 |
| 92 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.22953861 |
| 93 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.22017011 |
| 94 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.21314118 |
| 95 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.19788698 |
| 96 | Mineral absorption_Homo sapiens_hsa04978 | 0.19492491 |
| 97 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.16495555 |
| 98 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.15792177 |
| 99 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.15284523 |
| 100 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.15222199 |
| 101 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.14233399 |
| 102 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.14100657 |
| 103 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.11987874 |
| 104 | Retinol metabolism_Homo sapiens_hsa00830 | 0.10249120 |
| 105 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.09158145 |
| 106 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.08319538 |
| 107 | Histidine metabolism_Homo sapiens_hsa00340 | 0.07472590 |
| 108 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.05633621 |
| 109 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.03023414 |
| 110 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.01755502 |
| 111 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.01710121 |
| 112 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | -0.0168144 |
| 113 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | -0.0064968 |
| 114 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | -0.0047678 |

