NDUFAF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial complex I assembly protein that interacts with complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency, a fatal neonatal disorder of the oxidative phosphorylation system. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.12496462
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)6.81899439
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.78256770
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.74152801
5ATP synthesis coupled proton transport (GO:0015986)6.74152801
6respiratory electron transport chain (GO:0022904)5.87622939
7electron transport chain (GO:0022900)5.79206626
8epithelial cilium movement (GO:0003351)5.41243384
9pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.29082949
10axonemal dynein complex assembly (GO:0070286)5.28825584
11cilium or flagellum-dependent cell motility (GO:0001539)5.27947488
12acrosome reaction (GO:0007340)5.22143145
13sperm motility (GO:0030317)5.13251731
14cilium movement (GO:0003341)5.04204768
15motile cilium assembly (GO:0044458)4.93337015
16GTP biosynthetic process (GO:0006183)4.76572250
17regulation of cilium movement (GO:0003352)4.73106156
18fusion of sperm to egg plasma membrane (GO:0007342)4.45814042
19* protein complex biogenesis (GO:0070271)4.45502324
20pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.42160073
21purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.40428264
22pyrimidine nucleotide catabolic process (GO:0006244)4.39059104
23chaperone-mediated protein transport (GO:0072321)4.38314415
24protein localization to cilium (GO:0061512)4.32976380
25hydrogen ion transmembrane transport (GO:1902600)4.32925673
26ATP biosynthetic process (GO:0006754)4.30101411
27purine nucleoside triphosphate biosynthetic process (GO:0009145)4.30063854
28ribosomal small subunit biogenesis (GO:0042274)4.23624231
29* mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.21545416
30* mitochondrial respiratory chain complex I assembly (GO:0032981)4.21545416
31* NADH dehydrogenase complex assembly (GO:0010257)4.21545416
32deoxyribose phosphate biosynthetic process (GO:0046385)4.16419866
332-deoxyribonucleotide biosynthetic process (GO:0009265)4.16419866
34deoxyribonucleotide catabolic process (GO:0009264)4.11267752
35sperm-egg recognition (GO:0035036)4.10193261
36energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.09731969
37ATP hydrolysis coupled proton transport (GO:0015991)4.09731969
38protein neddylation (GO:0045116)4.08134871
39protein maturation by protein folding (GO:0022417)4.07495733
40* mitochondrial respiratory chain complex assembly (GO:0033108)4.04314740
41purine nucleotide salvage (GO:0032261)3.96680168
42viral transcription (GO:0019083)3.93854876
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.93244421
44multicellular organism reproduction (GO:0032504)3.91468781
45nucleoside diphosphate phosphorylation (GO:0006165)3.88282802
46deoxyribose phosphate catabolic process (GO:0046386)3.87790699
47UTP biosynthetic process (GO:0006228)3.86421675
48ribonucleoside triphosphate biosynthetic process (GO:0009201)3.86319631
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.85725430
50proton transport (GO:0015992)3.83676370
51binding of sperm to zona pellucida (GO:0007339)3.81669080
52hydrogen transport (GO:0006818)3.74712598
53spermatid development (GO:0007286)3.71544520
54translational termination (GO:0006415)3.71219702
55guanosine-containing compound biosynthetic process (GO:1901070)3.69091675
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.63814576
57metallo-sulfur cluster assembly (GO:0031163)3.62834402
58iron-sulfur cluster assembly (GO:0016226)3.62834402
59ribosomal small subunit assembly (GO:0000028)3.62011251
60intraciliary transport (GO:0042073)3.58664719
61mitochondrial calcium ion transport (GO:0006851)3.58597957
62deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.58265759
63DNA deamination (GO:0045006)3.58086033
64plasma membrane fusion (GO:0045026)3.57494139
652-deoxyribonucleotide metabolic process (GO:0009394)3.56930947
66protein targeting to ER (GO:0045047)3.56467621
67cotranslational protein targeting to membrane (GO:0006613)3.56264861
68cell-cell recognition (GO:0009988)3.52127067
69protein localization to endoplasmic reticulum (GO:0070972)3.51509910
70nucleoside triphosphate biosynthetic process (GO:0009142)3.48279266
71deoxyribose phosphate metabolic process (GO:0019692)3.48157947
72maturation of SSU-rRNA (GO:0030490)3.47907546
73translational elongation (GO:0006414)3.47492868
74axoneme assembly (GO:0035082)3.43585160
75CTP metabolic process (GO:0046036)3.41251160
76CTP biosynthetic process (GO:0006241)3.41251160
77establishment of protein localization to endoplasmic reticulum (GO:0072599)3.40751520
78calcium ion-dependent exocytosis (GO:0017156)3.39559171
79proteasome assembly (GO:0043248)3.39044406
80acrosome assembly (GO:0001675)3.36558274
81cell wall macromolecule metabolic process (GO:0044036)3.36262490
82cell wall macromolecule catabolic process (GO:0016998)3.36262490
83transcription elongation from RNA polymerase III promoter (GO:0006385)3.32674093
84termination of RNA polymerase III transcription (GO:0006386)3.32674093
85UTP metabolic process (GO:0046051)3.32407723
86inner mitochondrial membrane organization (GO:0007007)3.31286055
87negative regulation of inclusion body assembly (GO:0090084)3.26936606
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23140042
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23140042
90piRNA metabolic process (GO:0034587)3.22472657
91autophagic vacuole fusion (GO:0000046)3.21234578
92regulation of mitochondrial translation (GO:0070129)3.20285045
93pseudouridine synthesis (GO:0001522)3.19786324
94GMP metabolic process (GO:0046037)3.19574706
95purine-containing compound salvage (GO:0043101)3.18844875
96pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.18539509
97GDP-mannose metabolic process (GO:0019673)3.17664606
98mitochondrial transport (GO:0006839)3.17230101
99platelet dense granule organization (GO:0060155)3.16646003
100sperm capacitation (GO:0048240)3.14393318
101base-excision repair, AP site formation (GO:0006285)3.13766206
102respiratory chain complex IV assembly (GO:0008535)3.12886709
103regulation of oxidative phosphorylation (GO:0002082)3.12873346
104nucleotide salvage (GO:0043173)3.12609592
105deoxyribonucleotide metabolic process (GO:0009262)3.09503519
106negative regulation of B cell apoptotic process (GO:0002903)3.08594374
107viral life cycle (GO:0019058)3.07931323
108single fertilization (GO:0007338)3.05293071
109cullin deneddylation (GO:0010388)3.05281369
110neuron cell-cell adhesion (GO:0007158)3.03406846
111translation (GO:0006412)2.99844464
112purine deoxyribonucleotide catabolic process (GO:0009155)2.99273423
113reproduction (GO:0000003)2.98744173
114ubiquinone biosynthetic process (GO:0006744)2.98713507
115pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.98705307
116cytochrome complex assembly (GO:0017004)2.98478684
117purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.96309814
118ventricular system development (GO:0021591)2.96092869
119mannosylation (GO:0097502)2.93821369
120central nervous system myelination (GO:0022010)2.93492948
121axon ensheathment in central nervous system (GO:0032291)2.93492948
122aerobic respiration (GO:0009060)2.91077306
123cellular protein complex disassembly (GO:0043624)2.90630017
124presynaptic membrane assembly (GO:0097105)2.90013665
125dopamine transport (GO:0015872)2.89627826
126regulation of inclusion body assembly (GO:0090083)2.88555493
127transferrin transport (GO:0033572)2.88289394
128purine deoxyribonucleotide metabolic process (GO:0009151)2.87682282
129protein targeting to mitochondrion (GO:0006626)2.87123756
130oxidative phosphorylation (GO:0006119)2.86913238
131pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.84162145
132microtubule severing (GO:0051013)2.83359336
133negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.82701355
134regulation of dopamine metabolic process (GO:0042053)2.82090540
135regulation of catecholamine metabolic process (GO:0042069)2.82090540
136male meiosis (GO:0007140)2.81632371
137establishment of protein localization to mitochondrion (GO:0072655)2.80290766
138positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.79942161
139peptidyl-histidine modification (GO:0018202)2.77861121
140regulation of cellular amino acid metabolic process (GO:0006521)2.77830941
141regulation of microtubule-based movement (GO:0060632)2.77436262
142presynaptic membrane organization (GO:0097090)2.77039014
143sequestering of actin monomers (GO:0042989)2.76836794
144positive regulation of TOR signaling (GO:0032008)2.75247956
145* cellular component biogenesis (GO:0044085)2.75110035
146rRNA modification (GO:0000154)2.74655398
147substantia nigra development (GO:0021762)2.73366882
148protein deneddylation (GO:0000338)2.69876069
149deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.68580771
150trivalent inorganic cation transport (GO:0072512)2.66642080
151ferric iron transport (GO:0015682)2.66642080
152regulation of protein kinase A signaling (GO:0010738)2.66327234
153neuronal action potential propagation (GO:0019227)2.65738452
154cilium assembly (GO:0042384)2.64368349
155phagosome maturation (GO:0090382)2.63308170
156cilium organization (GO:0044782)2.63045585
157regulation of glutamate secretion (GO:0014048)2.55577060
158L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55569911
159protein localization to synapse (GO:0035418)2.55079837
160protein localization to mitochondrion (GO:0070585)2.54849401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62288674
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.33925175
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.54927413
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35229721
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.34744392
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.34330143
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.90246493
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89844526
9VDR_22108803_ChIP-Seq_LS180_Human2.73785510
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68142118
11GBX2_23144817_ChIP-Seq_PC3_Human2.68055195
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63541479
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.46017312
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44652820
15TAF15_26573619_Chip-Seq_HEK293_Human2.19263609
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17842819
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.14463686
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.13910612
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12998948
20XRN2_22483619_ChIP-Seq_HELA_Human2.09026389
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01978692
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01016484
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99618066
24GABP_19822575_ChIP-Seq_HepG2_Human1.97024179
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93203613
26DCP1A_22483619_ChIP-Seq_HELA_Human1.93114822
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91482943
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.91433721
29FOXP3_21729870_ChIP-Seq_TREG_Human1.90232483
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88553339
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.87584610
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85792293
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85291682
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83639330
35REST_21632747_ChIP-Seq_MESCs_Mouse1.82726439
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81769481
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79630003
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69691706
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68984708
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.68378918
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66182705
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62973471
43TTF2_22483619_ChIP-Seq_HELA_Human1.62158435
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61816613
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60049186
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58683117
47BCL6_27268052_Chip-Seq_Bcells_Human1.56798463
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50661332
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.49717975
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.48984401
51* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48916921
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48800418
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46113405
54VDR_21846776_ChIP-Seq_THP-1_Human1.45921752
55FUS_26573619_Chip-Seq_HEK293_Human1.44897062
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.44012981
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.43660121
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43331436
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.43223079
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41508998
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.39987160
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39822288
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.36534989
64* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36061968
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35751060
66* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35634251
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35193771
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33994045
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.33981209
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33796358
71ZNF274_21170338_ChIP-Seq_K562_Hela1.32978064
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32871534
73ZNF263_19887448_ChIP-Seq_K562_Human1.32857293
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32294566
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31701995
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31363644
77ER_23166858_ChIP-Seq_MCF-7_Human1.31199948
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30579411
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.30150313
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.29229141
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27953935
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27780720
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27327501
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27185894
85P300_19829295_ChIP-Seq_ESCs_Human1.27059399
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.24934462
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23355988
88* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23212443
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22598902
90P68_20966046_ChIP-Seq_HELA_Human1.22577821
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22322550
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22292029
93BCOR_27268052_Chip-Seq_Bcells_Human1.21307330
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20624737
95RNF2_27304074_Chip-Seq_NSC_Mouse1.19391524
96* CTCF_26484167_Chip-Seq_Bcells_Mouse1.19386379
97CTCF_20526341_ChIP-Seq_ESCs_Human1.18148785
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.18005517
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15496345
100CIITA_25753668_ChIP-Seq_RAJI_Human1.15214444
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15032395
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14851548
103STAT1_20625510_ChIP-Seq_HELA_Human1.13159736
104MYC_18940864_ChIP-ChIP_HL60_Human1.11248068
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10902568
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10893093
107* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09882667
108RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09851513
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09737969
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09670409
111KDM5A_27292631_Chip-Seq_BREAST_Human1.09384058
112SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08690512
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07245474
114MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06648937
115CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05980781
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.05584239
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04858282
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04535024
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04531398
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04421932
121CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03959222
122THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03559310
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02817587
124SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02728047
125JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01822947
126IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01678746
127IGF1R_20145208_ChIP-Seq_DFB_Human1.01543316
128P300_27268052_Chip-Seq_Bcells_Human1.01350685
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01027636
130E2F1_20622854_ChIP-Seq_HELA_Human1.00523953
131* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99867175
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99670743
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99507782
134PHF8_20622854_ChIP-Seq_HELA_Human0.98298440
135SPI1_20517297_ChIP-Seq_HL60_Human0.97266542
136* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97245305
137ELK1_19687146_ChIP-ChIP_HELA_Human0.96996369
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96503553
139GATA1_26923725_Chip-Seq_HPCs_Mouse0.96171986
140LXR_22292898_ChIP-Seq_THP-1_Human0.96140440
141TFEB_21752829_ChIP-Seq_HELA_Human0.95916064
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95782575
143TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95659986
144SMAD4_21799915_ChIP-Seq_A2780_Human0.95274661
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94992539
146CTCF_21964334_Chip-Seq_Bcells_Human0.94752189
147KDM2B_26808549_Chip-Seq_REH_Human0.94541715
148MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93932105
149NANOG_18555785_Chip-Seq_ESCs_Mouse0.93720516
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93501673
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92519065
152IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92298516
153ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92249423
154POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92228295
155TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91964373
156GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91600879
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91353232
158EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90796934
159PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88094118
160SOX2_22085726_ChIP-Seq_NPCs_Mouse0.87609651
161SOX9_26525672_Chip-Seq_HEART_Mouse0.86852581
162IRF1_19129219_ChIP-ChIP_H3396_Human0.86509478
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.86281829
164P53_22387025_ChIP-Seq_ESCs_Mouse0.85979493
165VDR_23849224_ChIP-Seq_CD4+_Human0.85268877
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85171765
167PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84648901
168ERG_20517297_ChIP-Seq_VCAP_Human0.84631778
169CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83899555
170STAT3_18555785_Chip-Seq_ESCs_Mouse0.82967651
171GATA3_21867929_ChIP-Seq_CD8_Mouse0.82579969
172TP53_22573176_ChIP-Seq_HFKS_Human0.82489525
173EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.82048516
174IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81110801
175CBP_20019798_ChIP-Seq_JUKART_Human0.81110801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.47802181
2MP0003880_abnormal_central_pattern4.22653775
3MP0005464_abnormal_platelet_physiology4.15519463
4MP0003806_abnormal_nucleotide_metabolis3.74485411
5MP0003186_abnormal_redox_activity3.08784517
6MP0001529_abnormal_vocalization3.02974377
7MP0002837_dystrophic_cardiac_calcinosis2.61506063
8MP0001905_abnormal_dopamine_level2.55964050
9MP0001968_abnormal_touch/_nociception2.54966597
10MP0002736_abnormal_nociception_after2.54116447
11MP0009046_muscle_twitch2.48122021
12MP0002272_abnormal_nervous_system2.28822491
13MP0009745_abnormal_behavioral_response2.24051364
14MP0003646_muscle_fatigue2.23212306
15MP0005058_abnormal_lysosome_morphology2.22946598
16MP0000372_irregular_coat_pigmentation2.22223465
17MP0002064_seizures2.20323549
18MP0006276_abnormal_autonomic_nervous2.18926834
19MP0001986_abnormal_taste_sensitivity2.15321237
20MP0005084_abnormal_gallbladder_morpholo2.14006898
21MP0003635_abnormal_synaptic_transmissio2.12775779
22MP0000343_altered_response_to2.12108966
23MP0003698_abnormal_male_reproductive2.07572480
24MP0001984_abnormal_olfaction2.05426642
25MP0005645_abnormal_hypothalamus_physiol2.03581744
26MP0004859_abnormal_synaptic_plasticity1.98209549
27MP0008877_abnormal_DNA_methylation1.94807701
28MP0002735_abnormal_chemical_nociception1.94686319
29MP0004270_analgesia1.93494679
30MP0002572_abnormal_emotion/affect_behav1.89504363
31MP0002734_abnormal_mechanical_nocicepti1.87333553
32MP0004142_abnormal_muscle_tone1.86629122
33MP0001486_abnormal_startle_reflex1.81493677
34MP0002132_abnormal_respiratory_system1.79244068
35MP0005423_abnormal_somatic_nervous1.79061111
36MP0004147_increased_porphyrin_level1.76336953
37MP0006036_abnormal_mitochondrial_physio1.75321168
38MP0002148_abnormal_hypersensitivity_rea1.71937748
39MP0002063_abnormal_learning/memory/cond1.69811095
40MP0003786_premature_aging1.69375577
41MP0001929_abnormal_gametogenesis1.67774891
42MP0005379_endocrine/exocrine_gland_phen1.67079847
43MP0001440_abnormal_grooming_behavior1.67021041
44MP0002822_catalepsy1.66465046
45MP0000465_gastrointestinal_hemorrhage1.62895077
46MP0008058_abnormal_DNA_repair1.59227077
47MP0009379_abnormal_foot_pigmentation1.58341400
48MP0005551_abnormal_eye_electrophysiolog1.57638905
49MP0002067_abnormal_sensory_capabilities1.55346892
50MP0005646_abnormal_pituitary_gland1.53429369
51MP0005670_abnormal_white_adipose1.52328458
52MP0003136_yellow_coat_color1.51670301
53MP0005671_abnormal_response_to1.51184324
54MP0001970_abnormal_pain_threshold1.51163683
55MP0009333_abnormal_splenocyte_physiolog1.49207509
56MP0002876_abnormal_thyroid_physiology1.48663567
57MP0000015_abnormal_ear_pigmentation1.48075653
58MP0005075_abnormal_melanosome_morpholog1.47866399
59MP0005083_abnormal_biliary_tract1.46337363
60MP0002163_abnormal_gland_morphology1.44824540
61MP0001764_abnormal_homeostasis1.41942817
62MP0008004_abnormal_stomach_pH1.38765332
63MP0010386_abnormal_urinary_bladder1.37629989
64MP0001188_hyperpigmentation1.36621097
65MP0006072_abnormal_retinal_apoptosis1.34426551
66MP0002733_abnormal_thermal_nociception1.33416790
67MP0000751_myopathy1.32358711
68MP0000358_abnormal_cell_content/1.31968852
69MP0008875_abnormal_xenobiotic_pharmacok1.31603927
70MP0001501_abnormal_sleep_pattern1.30500613
71MP0005332_abnormal_amino_acid1.30447628
72MP0004043_abnormal_pH_regulation1.30274974
73MP0006035_abnormal_mitochondrial_morpho1.28717212
74MP0008789_abnormal_olfactory_epithelium1.28286857
75MP0002234_abnormal_pharynx_morphology1.24621514
76MP0001835_abnormal_antigen_presentation1.22191068
77MP0001485_abnormal_pinna_reflex1.20567937
78MP0002557_abnormal_social/conspecific_i1.20429654
79MP0001756_abnormal_urination1.18181075
80MP0004924_abnormal_behavior1.17041061
81MP0005386_behavior/neurological_phenoty1.17041061
82MP0004742_abnormal_vestibular_system1.16467184
83MP0002638_abnormal_pupillary_reflex1.16433565
84MP0009764_decreased_sensitivity_to1.15145030
85MP0002229_neurodegeneration1.14975683
86MP0005499_abnormal_olfactory_system1.13968170
87MP0005394_taste/olfaction_phenotype1.13968170
88MP0002653_abnormal_ependyma_morphology1.13581190
89MP0009697_abnormal_copulation1.12043085
90MP0004215_abnormal_myocardial_fiber1.10665438
91MP0000631_abnormal_neuroendocrine_gland1.09922357
92MP0000920_abnormal_myelination1.08940853
93MP0000778_abnormal_nervous_system1.08641129
94MP0005165_increased_susceptibility_to1.08057266
95MP0005253_abnormal_eye_physiology1.07220572
96MP0003122_maternal_imprinting1.06466622
97MP0001545_abnormal_hematopoietic_system1.06156311
98MP0005397_hematopoietic_system_phenotyp1.06156311
99MP0001963_abnormal_hearing_physiology1.06086287
100MP0003075_altered_response_to1.06037204
101MP0000230_abnormal_systemic_arterial1.04362721
102MP0000749_muscle_degeneration1.03979444
103MP0003879_abnormal_hair_cell1.03354318
104MP0004036_abnormal_muscle_relaxation1.02904892
105MP0004133_heterotaxia1.01344082
106MP0003718_maternal_effect1.00600228
107MP0002160_abnormal_reproductive_system1.00160218
108MP0005000_abnormal_immune_tolerance0.99805482
109MP0002882_abnormal_neuron_morphology0.99199455
110MP0009785_altered_susceptibility_to0.98269187
111MP0005025_abnormal_response_to0.97473524
112MP0006292_abnormal_olfactory_placode0.97190155
113MP0002184_abnormal_innervation0.96833818
114MP0002161_abnormal_fertility/fecundity0.96627649
115MP0002066_abnormal_motor_capabilities/c0.96369684
116MP0008569_lethality_at_weaning0.96359101
117MP0005409_darkened_coat_color0.95488939
118MP0002210_abnormal_sex_determination0.92758841
119MP0009643_abnormal_urine_homeostasis0.92024469
120MP0003329_amyloid_beta_deposits0.91969302
121MP0000026_abnormal_inner_ear0.90676960
122MP0005266_abnormal_metabolism0.88932067
123MP0002095_abnormal_skin_pigmentation0.88175356
124MP0008873_increased_physiological_sensi0.88080274
125MP0002723_abnormal_immune_serum0.87605212
126MP0005584_abnormal_enzyme/coenzyme_acti0.87326286
127MP0004510_myositis0.87126080
128MP0009763_increased_sensitivity_to0.87086748
129MP0002398_abnormal_bone_marrow0.86774391
130MP0002752_abnormal_somatic_nervous0.86313158
131MP0005330_cardiomyopathy0.86100502
132MP0008872_abnormal_physiological_respon0.85651374
133MP0002693_abnormal_pancreas_physiology0.85633802
134MP0004145_abnormal_muscle_electrophysio0.85225829
135MP0009765_abnormal_xenobiotic_induced0.83512700
136MP0000685_abnormal_immune_system0.83493053
137MP0001845_abnormal_inflammatory_respons0.82941372
138MP0000689_abnormal_spleen_morphology0.82827371
139MP0001661_extended_life_span0.82334713
140MP0005389_reproductive_system_phenotype0.81651578
141MP0001853_heart_inflammation0.80205244
142MP0005535_abnormal_body_temperature0.80109771
143MP0002429_abnormal_blood_cell0.79799674
144MP0003656_abnormal_erythrocyte_physiolo0.79715345
145MP0003787_abnormal_imprinting0.79708511
146MP0008775_abnormal_heart_ventricle0.79456270
147MP0003638_abnormal_response/metabolism_0.79290615
148MP0008469_abnormal_protein_level0.78796471
149MP0003011_delayed_dark_adaptation0.78543111
150MP0003436_decreased_susceptibility_to0.78442168
151MP0003724_increased_susceptibility_to0.78010486
152MP0004085_abnormal_heartbeat0.77888317
153MP0003634_abnormal_glial_cell0.77830382
154MP0009642_abnormal_blood_homeostasis0.77517198
155MP0001727_abnormal_embryo_implantation0.77339696
156MP0002420_abnormal_adaptive_immunity0.76899203
157MP0004811_abnormal_neuron_physiology0.76504693
158MP0001919_abnormal_reproductive_system0.75752979
159MP0001502_abnormal_circadian_rhythm0.75405435
160MP0003137_abnormal_impulse_conducting0.74889681
161MP0003633_abnormal_nervous_system0.74436866
162MP0002909_abnormal_adrenal_gland0.74407661
163MP0001145_abnormal_male_reproductive0.73876095
164MP0000013_abnormal_adipose_tissue0.72729636
165MP0000955_abnormal_spinal_cord0.72274524
166MP0005636_abnormal_mineral_homeostasis0.68003172

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)6.23653352
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.85456628
3Absent/shortened dynein arms (HP:0200106)5.85456628
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.72795149
5* Abnormal mitochondria in muscle tissue (HP:0008316)5.70798561
6* Mitochondrial inheritance (HP:0001427)5.18104735
7* Progressive macrocephaly (HP:0004481)5.17008423
8Abnormal respiratory motile cilium physiology (HP:0012261)5.02074246
9* Acute encephalopathy (HP:0006846)4.96990316
10Abnormal respiratory epithelium morphology (HP:0012253)4.96224151
11Abnormal respiratory motile cilium morphology (HP:0005938)4.96224151
12Abnormal ciliary motility (HP:0012262)4.64017128
13Petechiae (HP:0000967)4.58920182
14Hepatocellular necrosis (HP:0001404)4.56383905
15* Increased CSF lactate (HP:0002490)4.39515176
16Rhinitis (HP:0012384)4.17837689
17Hepatic necrosis (HP:0002605)3.91446147
18Purpura (HP:0000979)3.77166466
19* Optic disc pallor (HP:0000543)3.61942703
20Medial flaring of the eyebrow (HP:0010747)3.60737671
21Chronic bronchitis (HP:0004469)3.37156427
22Generalized aminoaciduria (HP:0002909)3.35002829
23Increased hepatocellular lipid droplets (HP:0006565)3.34653626
24Prolonged bleeding time (HP:0003010)3.31549634
25* Cerebral edema (HP:0002181)3.13970855
26Renal Fanconi syndrome (HP:0001994)3.11898741
27* Respiratory failure (HP:0002878)3.10057418
28* Leukodystrophy (HP:0002415)3.06937832
29Lipid accumulation in hepatocytes (HP:0006561)3.03991168
30* Exercise intolerance (HP:0003546)3.02533498
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01774921
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01774921
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.00908529
34Gait imbalance (HP:0002141)2.96172608
35Congenital primary aphakia (HP:0007707)2.94693381
36Increased serum pyruvate (HP:0003542)2.93224200
37Abnormality of glycolysis (HP:0004366)2.93224200
383-Methylglutaconic aciduria (HP:0003535)2.89228747
39* Lactic acidosis (HP:0003128)2.88982980
40Infertility (HP:0000789)2.85451105
41Nephrogenic diabetes insipidus (HP:0009806)2.81563064
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75292812
43Dicarboxylic aciduria (HP:0003215)2.75292812
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74685837
45Focal motor seizures (HP:0011153)2.72388264
46Testicular atrophy (HP:0000029)2.69426009
47Increased intramyocellular lipid droplets (HP:0012240)2.68691937
48Hyperthyroidism (HP:0000836)2.67910774
49Abnormality of renal resorption (HP:0011038)2.64740789
50Increased serum lactate (HP:0002151)2.62922569
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59189688
52Abnormal protein N-linked glycosylation (HP:0012347)2.59189688
53Abnormal protein glycosylation (HP:0012346)2.59189688
54Abnormal glycosylation (HP:0012345)2.59189688
55Nephronophthisis (HP:0000090)2.58326285
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.50592416
57Menorrhagia (HP:0000132)2.48633788
58True hermaphroditism (HP:0010459)2.45247941
59Hyperventilation (HP:0002883)2.43988449
60Retinal dysplasia (HP:0007973)2.42771368
61Neuroendocrine neoplasm (HP:0100634)2.42670125
62Glycosuria (HP:0003076)2.41738944
63Abnormality of urine glucose concentration (HP:0011016)2.41738944
64Opisthotonus (HP:0002179)2.38319085
65Genital tract atresia (HP:0001827)2.33823670
66Progressive microcephaly (HP:0000253)2.33727345
67Vaginal atresia (HP:0000148)2.32867938
68Increased muscle lipid content (HP:0009058)2.32816391
69Pancreatic fibrosis (HP:0100732)2.31721718
70Microretrognathia (HP:0000308)2.29004100
71Emotional lability (HP:0000712)2.25928977
72Pheochromocytoma (HP:0002666)2.25676960
73Bronchiectasis (HP:0002110)2.22910852
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22292765
75Atonic seizures (HP:0010819)2.22249410
76Hypothermia (HP:0002045)2.21040875
77* Lethargy (HP:0001254)2.21040420
78Epileptic encephalopathy (HP:0200134)2.20190420
79Exertional dyspnea (HP:0002875)2.17880386
80Epistaxis (HP:0000421)2.16558529
81Muscle fiber atrophy (HP:0100295)2.16345083
82Increased mean platelet volume (HP:0011877)2.14719593
83Paralysis (HP:0003470)2.14610405
84Reduced antithrombin III activity (HP:0001976)2.13861138
85Ragged-red muscle fibers (HP:0003200)2.13706517
86Macrocytic anemia (HP:0001972)2.11586010
87Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10988064
88Reticulocytopenia (HP:0001896)2.07174058
89Myokymia (HP:0002411)2.02603498
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02431435
91Nausea (HP:0002018)1.99922193
92Aplastic anemia (HP:0001915)1.99651754
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.98934913
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98934913
95Abnormality of midbrain morphology (HP:0002418)1.98295947
96Molar tooth sign on MRI (HP:0002419)1.98295947
97Aplasia/Hypoplasia of the lens (HP:0008063)1.96996393
98Abnormal platelet volume (HP:0011876)1.95875821
99CNS demyelination (HP:0007305)1.94560180
100Abnormal hair whorl (HP:0010721)1.94373981
101Hepatosplenomegaly (HP:0001433)1.94273440
102Prolonged neonatal jaundice (HP:0006579)1.94200134
103Pancytopenia (HP:0001876)1.92162513
104Hypertensive crisis (HP:0100735)1.89198905
105Poor coordination (HP:0002370)1.88658913
106* X-linked dominant inheritance (HP:0001423)1.87664646
107Abnormality of the anterior horn cell (HP:0006802)1.87418906
108Degeneration of anterior horn cells (HP:0002398)1.87418906
109Type 2 muscle fiber atrophy (HP:0003554)1.86986785
110Abnormality of the renal medulla (HP:0100957)1.85358137
111Delusions (HP:0000746)1.84752816
112Poor suck (HP:0002033)1.83923665
113Chronic obstructive pulmonary disease (HP:0006510)1.83872441
114Obstructive lung disease (HP:0006536)1.83872441
115Ketoacidosis (HP:0001993)1.83547061
116Limb dystonia (HP:0002451)1.83472425
117Absence seizures (HP:0002121)1.83371070
118Cerebral palsy (HP:0100021)1.81270137
119Abnormality of fatty-acid metabolism (HP:0004359)1.80836123
120Ketosis (HP:0001946)1.79951583
121Respiratory difficulties (HP:0002880)1.79307251
122Pancreatic cysts (HP:0001737)1.79043128
123Rhabdomyolysis (HP:0003201)1.78470886
124Abnormality of cells of the erythroid lineage (HP:0012130)1.75256421
125Muscle hypertrophy of the lower extremities (HP:0008968)1.73088676
126Cholecystitis (HP:0001082)1.72963015
127Abnormal gallbladder physiology (HP:0012438)1.72963015
128Gliosis (HP:0002171)1.72339160
129Type I transferrin isoform profile (HP:0003642)1.72054900
130Abnormality of alanine metabolism (HP:0010916)1.70939241
131Hyperalaninemia (HP:0003348)1.70939241
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70939241
133Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70170540
134Bronchitis (HP:0012387)1.70042217
135Elevated erythrocyte sedimentation rate (HP:0003565)1.69631842
136Methylmalonic aciduria (HP:0012120)1.69545297
137Impaired platelet aggregation (HP:0003540)1.69544375
138Abnormal platelet function (HP:0011869)1.69544375
139Truncus arteriosus (HP:0001660)1.68196472
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68068808
141Abnormal pupillary function (HP:0007686)1.67885933
142Double outlet right ventricle (HP:0001719)1.65800220
143Congenital malformation of the right heart (HP:0011723)1.65800220
144Cerebral hypomyelination (HP:0006808)1.64850187
145Neurofibrillary tangles (HP:0002185)1.64058808
146Dialeptic seizures (HP:0011146)1.63695718
147Abnormal number of erythroid precursors (HP:0012131)1.63292759
148Methylmalonic acidemia (HP:0002912)1.62711902
149Tubulointerstitial nephritis (HP:0001970)1.61535491
150Nasal polyposis (HP:0100582)1.61018727
151Calf muscle hypertrophy (HP:0008981)1.58566888
152Short tibia (HP:0005736)1.56303440
153Median cleft lip (HP:0000161)1.55714065
154Polyphagia (HP:0002591)1.55612429
155Microvesicular hepatic steatosis (HP:0001414)1.55592364
156Left ventricular hypertrophy (HP:0001712)1.55163210
157Progressive inability to walk (HP:0002505)1.55063120
158Oculomotor apraxia (HP:0000657)1.52915225
159Hyperphosphaturia (HP:0003109)1.52332250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.97554451
2BCKDK4.63899360
3PDK33.56462524
4PDK43.56462524
5CASK3.40461121
6STK163.22113950
7MAP3K123.09656109
8TNIK2.65793996
9PNCK2.53118936
10STK392.43922160
11MAP3K112.41165526
12MAP2K72.34302972
13TESK12.25398953
14NME12.21128215
15BMPR22.18585313
16MST42.12330098
17PDK22.11986278
18KDR2.11668664
19CDK192.07721793
20MYLK1.94274209
21ARAF1.94052071
22ABL21.73738203
23MAP4K21.73255361
24OXSR11.64550254
25WNK41.63772168
26CCNB11.61216028
27MAP3K41.59523798
28ILK1.45663557
29BCR1.44818670
30ZAK1.44453011
31PRKD31.42690667
32PTK2B1.41694710
33RIPK41.40098373
34NUAK11.39584363
35EPHA41.35186289
36TLK11.30986706
37MAPKAPK31.27333024
38BRAF1.27252226
39IRAK31.26010746
40VRK11.24741818
41BMPR1B1.23499049
42BUB11.22763669
43NTRK31.21596505
44MAPKAPK51.20409568
45PBK1.18803510
46MUSK1.18305176
47SIK31.17975414
48MAPK151.17333623
49PLK21.17286530
50GRK71.11213270
51GRK51.06687459
52RPS6KA51.05020167
53ADRBK21.04759765
54TAOK21.03694630
55IKBKB1.03448987
56IRAK10.99969292
57CSNK1G20.98096926
58TESK20.96588468
59NEK10.96020400
60NME20.95922316
61CAMK2B0.95861420
62CAMK2A0.94880724
63LRRK20.91409566
64MINK10.86790512
65CSNK1G10.85950205
66CSNK1A1L0.83937296
67PIM20.82794400
68SCYL20.82293931
69PINK10.82015297
70NTRK20.81714612
71PRKCG0.81413397
72CAMK2D0.81247501
73GRK10.81003042
74TXK0.80002145
75TBK10.79848913
76PAK10.79059139
77UHMK10.78725844
78MAP2K40.75513776
79DAPK10.73643278
80EIF2AK30.73457089
81ADRBK10.69800462
82TAOK30.67806415
83MAPK130.67446348
84IRAK20.66999095
85TEC0.65415933
86AKT30.64168496
87KIT0.63979139
88LMTK20.63354410
89TNK20.62307796
90CAMKK20.61914529
91MAP2K30.61807924
92CAMK2G0.61483131
93OBSCN0.61438282
94CDC70.59944409
95BTK0.59901571
96ERBB30.58678695
97FES0.58225650
98PRKCE0.56820163
99BMX0.56161715
100CDK140.55239322
101LIMK10.54927964
102MARK10.54390780
103CDK180.54041910
104ICK0.53981335
105TSSK60.53721650
106DAPK30.52709624
107DYRK20.51638322
108ROCK20.51256475
109MAP4K10.51061388
110CDK30.50697618
111ERN10.49048427
112PRKCI0.49036734
113BLK0.49004419
114PKN10.48726198
115DYRK1A0.47792284
116CDK150.47381242
117STK40.47340658
118CDK50.46954782
119CSNK2A10.45854057
120CSNK2A20.45665717
121PRKACA0.45600774
122YES10.43710575
123PIK3CG0.43697577
124CDK11A0.43640085
125PRKCQ0.41478780
126WNK30.40981305
127DAPK20.40911279
128PLK40.38754603
129SYK0.38297244
130LYN0.37549963
131MAPK120.37518421
132PRPF4B0.36419787
133PRKCD0.35880988
134AURKB0.35332706
135CSNK1G30.34957738
136AURKA0.34754162
137FLT30.34712435
138MAP3K30.34367791
139MAPK110.34280653
140NTRK10.34267303
141PHKG10.33367863
142PHKG20.33367863
143MKNK20.33146034
144CHEK20.32267602
145GRK60.32168616
146PAK30.31632905
147EIF2AK10.30147968
148INSRR0.30096610
149SRPK10.30053401
150IKBKE0.28802589
151AKT20.28525087
152CDK80.27987856
153CSNK1A10.27792155
154PLK10.26583627

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.12046420
2Parkinsons disease_Homo sapiens_hsa050125.06110944
3Huntingtons disease_Homo sapiens_hsa050163.96945799
4Alzheimers disease_Homo sapiens_hsa050103.96229481
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.99226308
6Collecting duct acid secretion_Homo sapiens_hsa049662.91095374
7Cardiac muscle contraction_Homo sapiens_hsa042602.87006152
8Protein export_Homo sapiens_hsa030602.86816970
9Proteasome_Homo sapiens_hsa030502.77276156
10Sulfur relay system_Homo sapiens_hsa041222.54348523
11Ribosome_Homo sapiens_hsa030102.33654509
12DNA replication_Homo sapiens_hsa030302.12809326
13Synaptic vesicle cycle_Homo sapiens_hsa047212.05127388
14Nicotine addiction_Homo sapiens_hsa050332.00613393
15Base excision repair_Homo sapiens_hsa034101.99670371
16Vibrio cholerae infection_Homo sapiens_hsa051101.91097974
17Mismatch repair_Homo sapiens_hsa034301.81528328
18RNA polymerase_Homo sapiens_hsa030201.67720706
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63325785
20Pyruvate metabolism_Homo sapiens_hsa006201.63264682
21Phototransduction_Homo sapiens_hsa047441.46544072
22Amphetamine addiction_Homo sapiens_hsa050311.38847930
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38582488
24Fatty acid elongation_Homo sapiens_hsa000621.38204532
25Systemic lupus erythematosus_Homo sapiens_hsa053221.33439928
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31810019
27Sulfur metabolism_Homo sapiens_hsa009201.29941191
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27598081
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26066736
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25737590
31Primary immunodeficiency_Homo sapiens_hsa053401.23797370
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23134023
33Folate biosynthesis_Homo sapiens_hsa007901.18171410
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16909106
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16449627
36Taste transduction_Homo sapiens_hsa047421.15056988
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08918224
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08020144
39Morphine addiction_Homo sapiens_hsa050321.07238168
40GABAergic synapse_Homo sapiens_hsa047271.06947821
41Serotonergic synapse_Homo sapiens_hsa047261.01944495
42One carbon pool by folate_Homo sapiens_hsa006701.00465218
43Rheumatoid arthritis_Homo sapiens_hsa053231.00457990
44Propanoate metabolism_Homo sapiens_hsa006401.00290522
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99483538
46Circadian entrainment_Homo sapiens_hsa047130.97599900
47Pyrimidine metabolism_Homo sapiens_hsa002400.94820496
48Purine metabolism_Homo sapiens_hsa002300.92921646
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92807348
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92044974
51Glutamatergic synapse_Homo sapiens_hsa047240.91919093
52Fanconi anemia pathway_Homo sapiens_hsa034600.89521069
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88910363
54Long-term potentiation_Homo sapiens_hsa047200.88740901
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88130330
56Basal transcription factors_Homo sapiens_hsa030220.87587794
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86415751
58Dopaminergic synapse_Homo sapiens_hsa047280.85919433
59Olfactory transduction_Homo sapiens_hsa047400.83615475
60Ether lipid metabolism_Homo sapiens_hsa005650.82595345
61Metabolic pathways_Homo sapiens_hsa011000.79222176
62Calcium signaling pathway_Homo sapiens_hsa040200.75310977
63Cocaine addiction_Homo sapiens_hsa050300.75189916
64Linoleic acid metabolism_Homo sapiens_hsa005910.74739951
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74633242
66Insulin secretion_Homo sapiens_hsa049110.74124888
67Phagosome_Homo sapiens_hsa041450.67728755
68Renin secretion_Homo sapiens_hsa049240.67554363
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64825651
70Vitamin B6 metabolism_Homo sapiens_hsa007500.61662752
71Salivary secretion_Homo sapiens_hsa049700.60014711
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58946247
73Galactose metabolism_Homo sapiens_hsa000520.58526420
74Biosynthesis of amino acids_Homo sapiens_hsa012300.57574156
75Sphingolipid metabolism_Homo sapiens_hsa006000.57242521
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57187917
77Arachidonic acid metabolism_Homo sapiens_hsa005900.56946526
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54412580
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54005721
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.53896757
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.53812585
82Alcoholism_Homo sapiens_hsa050340.53481189
83Hematopoietic cell lineage_Homo sapiens_hsa046400.50485152
84Homologous recombination_Homo sapiens_hsa034400.49980498
85Arginine and proline metabolism_Homo sapiens_hsa003300.49801662
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.48708731
87Glutathione metabolism_Homo sapiens_hsa004800.47641931
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.47628933
89Chemical carcinogenesis_Homo sapiens_hsa052040.47508835
90Allograft rejection_Homo sapiens_hsa053300.46594163
91Carbon metabolism_Homo sapiens_hsa012000.45560694
92Nucleotide excision repair_Homo sapiens_hsa034200.45144039
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43898118
94Autoimmune thyroid disease_Homo sapiens_hsa053200.43415375
95Gastric acid secretion_Homo sapiens_hsa049710.42566116
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42559053
97Non-homologous end-joining_Homo sapiens_hsa034500.42290453
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41925972
99Long-term depression_Homo sapiens_hsa047300.40716357
100beta-Alanine metabolism_Homo sapiens_hsa004100.39704950
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.38456927
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38418669
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38112422
104Lysosome_Homo sapiens_hsa041420.37426822
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37276311
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36595326
107Tryptophan metabolism_Homo sapiens_hsa003800.36556554
108Antigen processing and presentation_Homo sapiens_hsa046120.34956334
109Fatty acid degradation_Homo sapiens_hsa000710.34770694
110Cholinergic synapse_Homo sapiens_hsa047250.34353152
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34066096
112Fatty acid metabolism_Homo sapiens_hsa012120.34039744
113RNA degradation_Homo sapiens_hsa030180.32697880
114Glucagon signaling pathway_Homo sapiens_hsa049220.31509034
115Type I diabetes mellitus_Homo sapiens_hsa049400.30610603
116Graft-versus-host disease_Homo sapiens_hsa053320.30489343
117Nitrogen metabolism_Homo sapiens_hsa009100.30405451
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.30345624
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29589043
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27750444
121Regulation of autophagy_Homo sapiens_hsa041400.27654456
122Platelet activation_Homo sapiens_hsa046110.27440057
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26937078
124Spliceosome_Homo sapiens_hsa030400.25991582
125Oocyte meiosis_Homo sapiens_hsa041140.25769391
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.25378253
127Phenylalanine metabolism_Homo sapiens_hsa003600.24721980
128Asthma_Homo sapiens_hsa053100.24270737
129Oxytocin signaling pathway_Homo sapiens_hsa049210.23615724
130Other glycan degradation_Homo sapiens_hsa005110.23010269
131Fructose and mannose metabolism_Homo sapiens_hsa000510.22989779
132Peroxisome_Homo sapiens_hsa041460.22144823
133Pentose phosphate pathway_Homo sapiens_hsa000300.22014293
134Pancreatic secretion_Homo sapiens_hsa049720.21788574
135N-Glycan biosynthesis_Homo sapiens_hsa005100.20964487
136Tyrosine metabolism_Homo sapiens_hsa003500.20450271
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19412864
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18751977
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17620388
140cAMP signaling pathway_Homo sapiens_hsa040240.14313543
141Steroid biosynthesis_Homo sapiens_hsa001000.14155323
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.13680418
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.12696986
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.12435948
145Butanoate metabolism_Homo sapiens_hsa006500.12349866

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