NDUFAF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene are a cause of mitochondrial complex I deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.98203796
2ATP synthesis coupled proton transport (GO:0015986)5.53909710
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.53909710
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.88462217
5respiratory electron transport chain (GO:0022904)4.76143574
6electron transport chain (GO:0022900)4.62886694
7proteasome assembly (GO:0043248)4.56070098
8chaperone-mediated protein transport (GO:0072321)4.27026382
9oxidative phosphorylation (GO:0006119)4.24222461
10rRNA modification (GO:0000154)4.18437218
11regulation of mitochondrial translation (GO:0070129)4.14704628
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.04983706
13protein deneddylation (GO:0000338)4.03530922
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.93146632
15cullin deneddylation (GO:0010388)3.92705966
16* mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.87837481
17* mitochondrial respiratory chain complex I assembly (GO:0032981)3.87837481
18* NADH dehydrogenase complex assembly (GO:0010257)3.87837481
19maturation of SSU-rRNA (GO:0030490)3.82670282
20maturation of 5.8S rRNA (GO:0000460)3.82137217
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.78317851
22termination of RNA polymerase III transcription (GO:0006386)3.78317851
23rRNA methylation (GO:0031167)3.72103967
24tricarboxylic acid cycle (GO:0006099)3.71688007
25* protein complex biogenesis (GO:0070271)3.70532776
26CENP-A containing nucleosome assembly (GO:0034080)3.65574698
27quinone biosynthetic process (GO:1901663)3.58719350
28ubiquinone biosynthetic process (GO:0006744)3.58719350
29amino acid salvage (GO:0043102)3.58524089
30L-methionine salvage (GO:0071267)3.58524089
31L-methionine biosynthetic process (GO:0071265)3.58524089
32DNA double-strand break processing (GO:0000729)3.56669230
337-methylguanosine mRNA capping (GO:0006370)3.56328789
34pseudouridine synthesis (GO:0001522)3.56101984
357-methylguanosine RNA capping (GO:0009452)3.54515122
36RNA capping (GO:0036260)3.54515122
37* mitochondrial respiratory chain complex assembly (GO:0033108)3.53052602
38chromatin remodeling at centromere (GO:0031055)3.49912077
39respiratory chain complex IV assembly (GO:0008535)3.48064231
40aerobic respiration (GO:0009060)3.46937665
41inner mitochondrial membrane organization (GO:0007007)3.42463476
42DNA damage response, detection of DNA damage (GO:0042769)3.40673549
43nucleobase biosynthetic process (GO:0046112)3.40097666
44mitotic metaphase plate congression (GO:0007080)3.36765820
45protein targeting to mitochondrion (GO:0006626)3.35574319
46histone mRNA metabolic process (GO:0008334)3.33252612
47DNA deamination (GO:0045006)3.32652252
48ubiquinone metabolic process (GO:0006743)3.31897628
49purine nucleobase biosynthetic process (GO:0009113)3.31365311
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31363774
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26923623
52regulation of mitotic spindle checkpoint (GO:1903504)3.26923623
53establishment of protein localization to mitochondrion (GO:0072655)3.25769569
54spliceosomal snRNP assembly (GO:0000387)3.25094344
55ribosome biogenesis (GO:0042254)3.21415608
56regulation of cellular amino acid metabolic process (GO:0006521)3.21404756
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.20798106
58establishment of integrated proviral latency (GO:0075713)3.20110195
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18246842
60kinetochore assembly (GO:0051382)3.17264217
61ribosomal large subunit biogenesis (GO:0042273)3.17092324
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17091804
63regulation of acyl-CoA biosynthetic process (GO:0050812)3.15543473
64* cellular component biogenesis (GO:0044085)3.14342956
65ribonucleoprotein complex biogenesis (GO:0022613)3.13983149
66cellular respiration (GO:0045333)3.13958336
67cytochrome complex assembly (GO:0017004)3.13437676
68protein neddylation (GO:0045116)3.11479701
69hydrogen ion transmembrane transport (GO:1902600)3.10866395
70protein localization to mitochondrion (GO:0070585)3.10753025
71kinetochore organization (GO:0051383)3.10233133
72NADH metabolic process (GO:0006734)3.10195622
73rRNA processing (GO:0006364)3.09835127
74IMP biosynthetic process (GO:0006188)3.06941898
75ATP biosynthetic process (GO:0006754)3.06088271
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03495556
77water-soluble vitamin biosynthetic process (GO:0042364)3.01692245
78regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.01583094
79rRNA metabolic process (GO:0016072)3.00487887
80positive regulation of ligase activity (GO:0051351)2.99945497
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99825046
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99825046
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99825046
84purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99108805
85DNA replication checkpoint (GO:0000076)2.98843706
86telomere maintenance via semi-conservative replication (GO:0032201)2.98516130
87regulation of cofactor metabolic process (GO:0051193)2.98412680
88regulation of coenzyme metabolic process (GO:0051196)2.98412680
89intracellular protein transmembrane import (GO:0044743)2.98097017
90peptidyl-histidine modification (GO:0018202)2.97313316
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96908203
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96908203
93protein-cofactor linkage (GO:0018065)2.95793426
94ribosomal small subunit assembly (GO:0000028)2.95679555
95DNA replication initiation (GO:0006270)2.95641189
96purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.95389516
97transcription from mitochondrial promoter (GO:0006390)2.95243098
98negative regulation of ligase activity (GO:0051352)2.94360060
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94360060
100DNA strand elongation involved in DNA replication (GO:0006271)2.93787052
101ribosomal small subunit biogenesis (GO:0042274)2.93074502
102DNA catabolic process, exonucleolytic (GO:0000738)2.91830496
103transcription elongation from RNA polymerase I promoter (GO:0006362)2.91707281
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91518293
105DNA replication-independent nucleosome organization (GO:0034724)2.90653560
106DNA replication-independent nucleosome assembly (GO:0006336)2.90653560
107histone exchange (GO:0043486)2.89637667
108methionine metabolic process (GO:0006555)2.89413950
109signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89195032
110signal transduction involved in DNA damage checkpoint (GO:0072422)2.89195032
111cotranslational protein targeting to membrane (GO:0006613)2.88778856
112regulation of ubiquitin-protein transferase activity (GO:0051438)2.87631709
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87584172
114SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87422633
115signal transduction involved in cell cycle checkpoint (GO:0072395)2.87037845
1162-deoxyribonucleotide biosynthetic process (GO:0009265)2.86421832
117deoxyribose phosphate biosynthetic process (GO:0046385)2.86421832
118mitochondrial transport (GO:0006839)2.86222717
119termination of RNA polymerase I transcription (GO:0006363)2.86197995
120ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86079453
121DNA strand elongation (GO:0022616)2.85866510
122positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85752386
123transcription-coupled nucleotide-excision repair (GO:0006283)2.85288082
124ribosome assembly (GO:0042255)2.83087085
125purine nucleoside monophosphate biosynthetic process (GO:0009127)2.82921140
126purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.82921140
127translation (GO:0006412)2.82189499
128metaphase plate congression (GO:0051310)2.81795769
129protein targeting to ER (GO:0045047)2.81786166
130RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79811175
131tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79811175
132formation of translation preinitiation complex (GO:0001731)2.78809116
133translational termination (GO:0006415)2.77709218
134regulation of ligase activity (GO:0051340)2.76866903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.24529550
2E2F7_22180533_ChIP-Seq_HELA_Human4.39597424
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.38245780
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.30785137
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.17294403
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.93553175
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.51165175
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50741794
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39711983
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.34441543
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25471452
12* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01353539
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94210612
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93055764
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85748918
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81294640
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.76959980
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60697365
19VDR_23849224_ChIP-Seq_CD4+_Human2.56473362
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.44499052
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41231772
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40017458
23DCP1A_22483619_ChIP-Seq_HELA_Human2.39326603
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32014000
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29659933
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.29300904
27FOXP3_21729870_ChIP-Seq_TREG_Human2.23279605
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22066568
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.19921321
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16935995
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11078153
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08295582
33ELK1_19687146_ChIP-ChIP_HELA_Human2.06132607
34GABP_19822575_ChIP-Seq_HepG2_Human2.05024042
35XRN2_22483619_ChIP-Seq_HELA_Human2.02848192
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92875281
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91024183
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87003293
39* TTF2_22483619_ChIP-Seq_HELA_Human1.81010582
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.78914789
41AR_21909140_ChIP-Seq_LNCAP_Human1.77519002
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74497796
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70325723
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66239829
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63646413
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61811559
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.58243781
48MYC_18940864_ChIP-ChIP_HL60_Human1.54164635
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53153215
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51941632
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.41560868
52FUS_26573619_Chip-Seq_HEK293_Human1.37570297
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35549134
54ZNF274_21170338_ChIP-Seq_K562_Hela1.35226344
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29423407
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28478871
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27669075
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27503638
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27439615
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26494914
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26202665
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24547642
63IGF1R_20145208_ChIP-Seq_DFB_Human1.21770400
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21677416
65* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20607275
66IRF1_19129219_ChIP-ChIP_H3396_Human1.19082563
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.18861207
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18326302
69KDM5A_27292631_Chip-Seq_BREAST_Human1.16602242
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14547243
71P300_19829295_ChIP-Seq_ESCs_Human1.13716478
72* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12973791
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12624201
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12072791
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.11710998
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.11091890
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.08537768
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08512401
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.04844848
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04426575
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04065127
82EWS_26573619_Chip-Seq_HEK293_Human1.02407697
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99145795
84TAF15_26573619_Chip-Seq_HEK293_Human0.98969840
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98281032
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98235422
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97217197
88NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96555535
89CIITA_25753668_ChIP-Seq_RAJI_Human0.96248661
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95526858
91VDR_22108803_ChIP-Seq_LS180_Human0.95413913
92TP53_22573176_ChIP-Seq_HFKS_Human0.95413893
93GBX2_23144817_ChIP-Seq_PC3_Human0.94964234
94HTT_18923047_ChIP-ChIP_STHdh_Human0.94182501
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94049863
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93444004
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.92128861
98ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91913507
99* EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91480297
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88885374
101CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87787677
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87057372
103EZH2_27294783_Chip-Seq_NPCs_Mouse0.85958878
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84743597
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82930841
106SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81041853
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.80843239
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80726662
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79166059
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77848709
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77093237
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75173002
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.74538749
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73830115
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71744506
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70685443
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70443111
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70025877
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.69233159
120* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.67863752
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66567267
122GATA4_21415370_ChIP-Seq_HL-1_Mouse0.65285730
123REST_19997604_ChIP-ChIP_NEURONS_Mouse0.64804457
124ELF5_23300383_ChIP-Seq_T47D_Human0.63615943
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.63521215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.96326026
2MP0003646_muscle_fatigue3.79044845
3MP0003806_abnormal_nucleotide_metabolis3.38505141
4MP0006036_abnormal_mitochondrial_physio3.07013506
5MP0004957_abnormal_blastocyst_morpholog2.90429009
6MP0002139_abnormal_hepatobiliary_system2.85785720
7MP0009379_abnormal_foot_pigmentation2.75563160
8MP0010094_abnormal_chromosome_stability2.66779865
9MP0001529_abnormal_vocalization2.63122381
10MP0002837_dystrophic_cardiac_calcinosis2.58659808
11MP0004215_abnormal_myocardial_fiber2.48579207
12MP0003718_maternal_effect2.45169258
13MP0004147_increased_porphyrin_level2.32326451
14MP0009697_abnormal_copulation2.31872024
15MP0006035_abnormal_mitochondrial_morpho2.30207676
16MP0005085_abnormal_gallbladder_physiolo2.25484233
17MP0008057_abnormal_DNA_replication2.20568027
18MP0009046_muscle_twitch2.18335419
19MP0005360_urolithiasis2.08513381
20MP0008058_abnormal_DNA_repair2.06304598
21MP0003077_abnormal_cell_cycle2.05020922
22MP0003123_paternal_imprinting1.95366681
23MP0000372_irregular_coat_pigmentation1.91785141
24MP0006072_abnormal_retinal_apoptosis1.88168467
25MP0008932_abnormal_embryonic_tissue1.85422856
26MP0003111_abnormal_nucleus_morphology1.84014695
27MP0002102_abnormal_ear_morphology1.83035356
28MP0003186_abnormal_redox_activity1.80879877
29MP0003656_abnormal_erythrocyte_physiolo1.79363334
30MP0002272_abnormal_nervous_system1.79290550
31MP0008875_abnormal_xenobiotic_pharmacok1.76074889
32MP0006292_abnormal_olfactory_placode1.75327610
33MP0008877_abnormal_DNA_methylation1.74453019
34MP0008789_abnormal_olfactory_epithelium1.73671783
35MP0006276_abnormal_autonomic_nervous1.67811612
36MP0001764_abnormal_homeostasis1.61809477
37MP0005365_abnormal_bile_salt1.59671941
38MP0003941_abnormal_skin_development1.58269859
39MP0002938_white_spotting1.55903763
40MP0003880_abnormal_central_pattern1.55268914
41MP0004084_abnormal_cardiac_muscle1.54342909
42MP0005330_cardiomyopathy1.49550886
43MP0000749_muscle_degeneration1.43887499
44MP0005266_abnormal_metabolism1.43074917
45MP0003221_abnormal_cardiomyocyte_apopto1.41853387
46MP0001905_abnormal_dopamine_level1.41519021
47MP0004742_abnormal_vestibular_system1.41324930
48MP0009745_abnormal_behavioral_response1.40598866
49MP0004036_abnormal_muscle_relaxation1.37096531
50MP0001188_hyperpigmentation1.32539580
51MP0003136_yellow_coat_color1.31157404
52MP0005332_abnormal_amino_acid1.27334941
53MP0008872_abnormal_physiological_respon1.25982388
54MP0005394_taste/olfaction_phenotype1.21579918
55MP0005499_abnormal_olfactory_system1.21579918
56MP0003137_abnormal_impulse_conducting1.20434258
57MP0000751_myopathy1.20334465
58MP0001984_abnormal_olfaction1.20045967
59MP0001486_abnormal_startle_reflex1.19191223
60MP0005187_abnormal_penis_morphology1.18120753
61MP0005551_abnormal_eye_electrophysiolog1.17834090
62MP0004145_abnormal_muscle_electrophysio1.17818658
63MP0001293_anophthalmia1.17341223
64MP0005084_abnormal_gallbladder_morpholo1.16118101
65MP0005451_abnormal_body_composition1.16101920
66MP0003890_abnormal_embryonic-extraembry1.15607825
67MP0008007_abnormal_cellular_replicative1.15480063
68MP0005253_abnormal_eye_physiology1.15174666
69MP0010386_abnormal_urinary_bladder1.13974816
70MP0002734_abnormal_mechanical_nocicepti1.12436236
71MP0004043_abnormal_pH_regulation1.12040031
72MP0002160_abnormal_reproductive_system1.10124631
73MP0002234_abnormal_pharynx_morphology1.09489346
74MP0002735_abnormal_chemical_nociception1.09214819
75MP0001485_abnormal_pinna_reflex1.08311642
76MP0003011_delayed_dark_adaptation1.07207606
77MP0002067_abnormal_sensory_capabilities1.04824387
78MP0003635_abnormal_synaptic_transmissio1.04729516
79MP0003786_premature_aging1.04288650
80MP0003121_genomic_imprinting1.01968200
81MP0004270_analgesia1.01252273
82MP0002090_abnormal_vision1.01002726
83MP0002064_seizures1.00977849
84MP0002736_abnormal_nociception_after0.97468896
85MP0004484_altered_response_of0.97263948
86MP0002127_abnormal_cardiovascular_syste0.96185463
87MP0001730_embryonic_growth_arrest0.94531811
88MP0005636_abnormal_mineral_homeostasis0.94037539
89MP0000631_abnormal_neuroendocrine_gland0.94015245
90MP0003787_abnormal_imprinting0.92680254
91MP0008775_abnormal_heart_ventricle0.92628106
92MP0002269_muscular_atrophy0.92163431
93MP0002751_abnormal_autonomic_nervous0.91398325
94MP0002876_abnormal_thyroid_physiology0.90627154
95MP0002572_abnormal_emotion/affect_behav0.90306989
96MP0004142_abnormal_muscle_tone0.87903915
97MP0002132_abnormal_respiratory_system0.87080230
98MP0005410_abnormal_fertilization0.86725244
99MP0003868_abnormal_feces_composition0.86282583
100MP0005376_homeostasis/metabolism_phenot0.86197330
101MP0001119_abnormal_female_reproductive0.85881134
102MP0005620_abnormal_muscle_contractility0.85848079
103MP0002972_abnormal_cardiac_muscle0.84740711
104MP0005408_hypopigmentation0.84614176
105MP0001440_abnormal_grooming_behavior0.84075516
106MP0002277_abnormal_respiratory_mucosa0.84041453
107MP0005645_abnormal_hypothalamus_physiol0.83750382
108MP0002396_abnormal_hematopoietic_system0.81823064
109MP0001697_abnormal_embryo_size0.81742873
110MP0003119_abnormal_digestive_system0.79372879
111MP0005646_abnormal_pituitary_gland0.79282126
112MP0004859_abnormal_synaptic_plasticity0.79255706
113MP0005389_reproductive_system_phenotype0.78389494
114MP0002138_abnormal_hepatobiliary_system0.78271942
115MP0001145_abnormal_male_reproductive0.78172568
116MP0004133_heterotaxia0.78087643
117MP0005319_abnormal_enzyme/_coenzyme0.77340225
118MP0004085_abnormal_heartbeat0.77161034
119MP0005423_abnormal_somatic_nervous0.77137716
120MP0002184_abnormal_innervation0.77092205
121MP0003698_abnormal_male_reproductive0.76883712
122MP0002638_abnormal_pupillary_reflex0.76084059
123MP0005386_behavior/neurological_phenoty0.75736524
124MP0004924_abnormal_behavior0.75736524
125MP0003195_calcinosis0.75601101
126MP0000750_abnormal_muscle_regeneration0.75486545
127MP0000647_abnormal_sebaceous_gland0.75386095
128MP0000653_abnormal_sex_gland0.75300614
129MP0002210_abnormal_sex_determination0.74841446
130MP0008995_early_reproductive_senescence0.73911222
131MP0002106_abnormal_muscle_physiology0.73394984
132MP0000350_abnormal_cell_proliferation0.71514757
133MP0001929_abnormal_gametogenesis0.71028395
134MP0003567_abnormal_fetal_cardiomyocyte0.70897504
135MP0002332_abnormal_exercise_endurance0.68963235
136MP0000358_abnormal_cell_content/0.68213005
137MP0003315_abnormal_perineum_morphology0.65892397
138MP0005380_embryogenesis_phenotype0.65864342
139MP0001672_abnormal_embryogenesis/_devel0.65864342
140MP0002163_abnormal_gland_morphology0.65236630
141MP0001968_abnormal_touch/_nociception0.63809376
142MP0002080_prenatal_lethality0.63671871
143MP0001544_abnormal_cardiovascular_syste0.62714777

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)5.69136614
2* Abnormal mitochondria in muscle tissue (HP:0008316)5.29044767
3* Acute encephalopathy (HP:0006846)5.06063376
4Hepatocellular necrosis (HP:0001404)5.01232391
5* Mitochondrial inheritance (HP:0001427)4.98851974
6* Increased CSF lactate (HP:0002490)4.81624848
7Hepatic necrosis (HP:0002605)4.75403971
8* Progressive macrocephaly (HP:0004481)4.73910656
9Abnormality of glycolysis (HP:0004366)4.39260921
10Increased serum pyruvate (HP:0003542)4.39260921
11Increased hepatocellular lipid droplets (HP:0006565)4.00732494
12* Cerebral edema (HP:0002181)3.91101306
13Lipid accumulation in hepatocytes (HP:0006561)3.82393769
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.80340332
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.80340332
16Increased serum lactate (HP:0002151)3.78282416
17* Lactic acidosis (HP:0003128)3.72487947
18Birth length less than 3rd percentile (HP:0003561)3.62948004
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.58247112
20Abnormality of alanine metabolism (HP:0010916)3.43479452
21Hyperalaninemia (HP:0003348)3.43479452
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.43479452
23Increased intramyocellular lipid droplets (HP:0012240)3.33561907
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.32873919
25* Exercise intolerance (HP:0003546)3.29835233
26* Respiratory failure (HP:0002878)3.23344542
27Methylmalonic acidemia (HP:0002912)3.20287985
28Renal Fanconi syndrome (HP:0001994)3.14219214
29Increased muscle lipid content (HP:0009058)3.01518794
30Respiratory difficulties (HP:0002880)2.89906177
31* Lethargy (HP:0001254)2.86143306
32CNS demyelination (HP:0007305)2.84102407
33Irregular epiphyses (HP:0010582)2.79966128
34Aplastic anemia (HP:0001915)2.74989477
353-Methylglutaconic aciduria (HP:0003535)2.73923508
36Microvesicular hepatic steatosis (HP:0001414)2.73434903
37* Optic disc pallor (HP:0000543)2.72119376
38Oral leukoplakia (HP:0002745)2.70165974
39Exertional dyspnea (HP:0002875)2.61659437
40Hyperglycinemia (HP:0002154)2.49768206
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.49229907
42Breast hypoplasia (HP:0003187)2.46006098
43Abnormality of serum amino acid levels (HP:0003112)2.45525108
44* Leukodystrophy (HP:0002415)2.44256378
45Palpitations (HP:0001962)2.42405150
46Hypobetalipoproteinemia (HP:0003563)2.41729646
47Congenital, generalized hypertrichosis (HP:0004540)2.41307110
48Colon cancer (HP:0003003)2.38695858
49Myokymia (HP:0002411)2.37208377
50Generalized aminoaciduria (HP:0002909)2.35472946
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32131624
52Dicarboxylic aciduria (HP:0003215)2.32131624
53Abnormality of urine glucose concentration (HP:0011016)2.29121491
54Glycosuria (HP:0003076)2.29121491
55Unsteady gait (HP:0002317)2.26855326
56Abnormality of cells of the erythroid lineage (HP:0012130)2.24073460
57Cerebral hypomyelination (HP:0006808)2.20261434
58Emotional lability (HP:0000712)2.19961402
59Abnormal number of erythroid precursors (HP:0012131)2.17040136
60Atonic seizures (HP:0010819)2.14623481
61Degeneration of anterior horn cells (HP:0002398)2.14001745
62Abnormality of the anterior horn cell (HP:0006802)2.14001745
63Rhabdomyolysis (HP:0003201)2.09219704
64Focal motor seizures (HP:0011153)2.07543775
65Methylmalonic aciduria (HP:0012120)2.02800580
66Reduced antithrombin III activity (HP:0001976)2.02350208
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00781508
68Secondary amenorrhea (HP:0000869)1.99457664
69Abnormality of renal resorption (HP:0011038)1.99327601
70Abnormality of methionine metabolism (HP:0010901)1.93972112
71Rough bone trabeculation (HP:0100670)1.92208999
72Hyperglycinuria (HP:0003108)1.91294463
73Macrocytic anemia (HP:0001972)1.91098303
74Ragged-red muscle fibers (HP:0003200)1.89820651
75Abnormality of fatty-acid metabolism (HP:0004359)1.89738982
76Type I transferrin isoform profile (HP:0003642)1.88723695
77* X-linked dominant inheritance (HP:0001423)1.88465761
78Hyperammonemia (HP:0001987)1.87416581
79Meckel diverticulum (HP:0002245)1.86989930
80Abnormality of glycine metabolism (HP:0010895)1.86087544
81Abnormality of serine family amino acid metabolism (HP:0010894)1.86087544
82Gliosis (HP:0002171)1.85562127
83Abnormal protein glycosylation (HP:0012346)1.84533154
84Abnormal glycosylation (HP:0012345)1.84533154
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84533154
86Abnormal protein N-linked glycosylation (HP:0012347)1.84533154
87* Vomiting (HP:0002013)1.84093094
88Hyperphosphaturia (HP:0003109)1.83365065
89Hyperventilation (HP:0002883)1.83045901
90Progressive external ophthalmoplegia (HP:0000590)1.81326069
91Abnormality of the vitamin B12 metabolism (HP:0004341)1.80672316
92Abnormal lung lobation (HP:0002101)1.80489716
93Metabolic acidosis (HP:0001942)1.80357196
94Neuroendocrine neoplasm (HP:0100634)1.80345574
95Hypoglycemic coma (HP:0001325)1.80220055
96Abnormality of the ileum (HP:0001549)1.79922378
97Patellar aplasia (HP:0006443)1.78474148
98Absence seizures (HP:0002121)1.77287004
99Congenital primary aphakia (HP:0007707)1.76349317
100Abnormality of vitamin B metabolism (HP:0004340)1.75720261
101Febrile seizures (HP:0002373)1.75547403
102Amniotic constriction ring (HP:0009775)1.74906872
103Abnormality of placental membranes (HP:0011409)1.74906872
104Megaloblastic anemia (HP:0001889)1.72083825
105Nephrogenic diabetes insipidus (HP:0009806)1.71701103
106Molar tooth sign on MRI (HP:0002419)1.71389730
107Abnormality of midbrain morphology (HP:0002418)1.71389730
108Pancreatic fibrosis (HP:0100732)1.71117362
109Renal cortical cysts (HP:0000803)1.70620570
110Gait imbalance (HP:0002141)1.68772231
111Broad-based gait (HP:0002136)1.68739127
112Abnormality of chromosome stability (HP:0003220)1.68067260
113Neoplasm of the adrenal gland (HP:0100631)1.67911123
114Acute hepatic failure (HP:0006554)1.67694238
115Carpal bone hypoplasia (HP:0001498)1.67309049
116Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66797851
117Medial flaring of the eyebrow (HP:0010747)1.66026339
118Delusions (HP:0000746)1.65521337
119Pancreatic cysts (HP:0001737)1.65449383
120Pancreatic islet-cell hyperplasia (HP:0004510)1.65439307
121Septo-optic dysplasia (HP:0100842)1.65271541
122Aplasia/Hypoplasia of the patella (HP:0006498)1.64673374
123Reticulocytopenia (HP:0001896)1.63533512
124Cholecystitis (HP:0001082)1.63342148
125Abnormal gallbladder physiology (HP:0012438)1.63342148
126Pheochromocytoma (HP:0002666)1.62844449
127Dialeptic seizures (HP:0011146)1.61637905
128Abnormality of lateral ventricle (HP:0030047)1.61576933
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.61059523
130Poor suck (HP:0002033)1.60858239
131Abnormality of the labia minora (HP:0012880)1.60852015
132Hypothermia (HP:0002045)1.59856152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.08130135
2EIF2AK14.00785863
3VRK23.33886581
4NME23.05387027
5MST42.99189660
6BUB12.84840019
7SRPK12.68488471
8WEE12.57689722
9CDC72.39875045
10EIF2AK32.39793333
11MUSK2.38367312
12MAP3K122.37183128
13PLK42.30813243
14NME12.10563138
15VRK12.03268650
16CDK192.00103332
17BMPR1B1.98604616
18MAP2K71.86482540
19TRIM281.86047387
20TNIK1.76422840
21NUAK11.75843932
22NEK11.75171186
23BCKDK1.73654022
24MKNK21.70561007
25BRAF1.69520935
26PDK31.69520732
27PDK41.69520732
28ACVR1B1.68191510
29CASK1.54852598
30PLK31.54495183
31OBSCN1.53119627
32TSSK61.52356545
33MKNK11.52074103
34CDK81.52015635
35TAF11.46667504
36MAP4K21.39974586
37STK38L1.38343877
38MAP3K61.35173025
39CSNK1G21.34977617
40CSNK1G11.31949201
41TTK1.31059932
42PLK11.24149084
43PLK21.23536855
44BRSK21.22274924
45MYLK1.21016650
46ARAF1.20294924
47ERBB41.17449336
48TLK11.13777255
49STK241.13235611
50CCNB11.13142354
51MAP3K41.08352741
52MAP2K41.05259121
53AURKA1.00427505
54ERBB30.98086868
55CSNK1A1L0.93199489
56ZAK0.92640366
57MAPK130.92263669
58AURKB0.90204854
59MAP3K110.88729315
60GRK10.86875695
61DAPK10.85161543
62PHKG10.83276021
63PHKG20.83276021
64PIM20.81461526
65ABL20.81461485
66MAP3K50.81237763
67RAF10.80670692
68ADRBK20.79600579
69OXSR10.78571449
70PRKCG0.76005633
71LATS20.74071615
72BMPR20.73912720
73PBK0.73087637
74PDK20.71997506
75INSRR0.71980245
76CHEK20.71940204
77EIF2AK20.71445920
78AKT30.71209449
79CDK30.65362518
80GRK70.65327887
81BRSK10.64566483
82PIK3CA0.64174410
83EPHA40.64171612
84PNCK0.63753181
85CSNK2A20.61079781
86CSNK2A10.60761795
87WNK30.60441703
88PINK10.60008633
89ALK0.57760773
90DYRK20.56347473
91ATR0.54831559
92STK40.53632158
93CDK70.53073421
94STK30.50502073
95MAPKAPK50.49196850
96MAPKAPK30.48131231
97TIE10.46422859
98GRK50.46175237
99DAPK30.45885204
100TAOK20.45815387
101STK390.45427617
102RPS6KA50.44031603
103MINK10.42968849
104LIMK10.42777124
105MELK0.42707872
106NTRK30.42338763
107CSNK1A10.42226356
108CHEK10.42204700
109KDR0.41829617
110RPS6KA40.41712063
111CAMK2A0.41123944
112CSNK1G30.39078380
113PRKCE0.38976959
114DYRK30.38639977
115ATM0.38596005
116PRKG10.37689926
117PAK30.36722854
118CAMK2D0.34610846
119FRK0.34117693
120PASK0.33650043
121TEC0.33018525
122CDK140.32582016
123RPS6KB20.32489821
124UHMK10.31848233
125CAMK2B0.31180737
126PRKDC0.30952898
127MAPK120.30772879
128CSNK1E0.30748143
129ILK0.30109436
130CDK40.29773834
131PRKACA0.29205655
132ADRBK10.28766998
133CAMK2G0.27936517
134CDK10.26941397
135CDK20.26561739
136BCR0.25526165

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.74560535
2Proteasome_Homo sapiens_hsa030503.40214781
3Parkinsons disease_Homo sapiens_hsa050123.39501336
4RNA polymerase_Homo sapiens_hsa030203.36231382
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.99129708
6Ribosome_Homo sapiens_hsa030102.91002335
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81701939
8DNA replication_Homo sapiens_hsa030302.70181388
9Huntingtons disease_Homo sapiens_hsa050162.53166220
10Mismatch repair_Homo sapiens_hsa034302.42063452
11Alzheimers disease_Homo sapiens_hsa050102.31011104
12Pyrimidine metabolism_Homo sapiens_hsa002402.21216747
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02255857
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98584666
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.97939125
16Protein export_Homo sapiens_hsa030601.97572787
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94041837
18Spliceosome_Homo sapiens_hsa030401.90899682
19RNA transport_Homo sapiens_hsa030131.86441428
20Nucleotide excision repair_Homo sapiens_hsa034201.81176387
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.80931469
22RNA degradation_Homo sapiens_hsa030181.80474711
23Pyruvate metabolism_Homo sapiens_hsa006201.78679570
24Homologous recombination_Homo sapiens_hsa034401.75856365
25Basal transcription factors_Homo sapiens_hsa030221.70534644
26Propanoate metabolism_Homo sapiens_hsa006401.69891118
27Cardiac muscle contraction_Homo sapiens_hsa042601.60384829
28One carbon pool by folate_Homo sapiens_hsa006701.52412768
29Carbon metabolism_Homo sapiens_hsa012001.50092055
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47067874
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43564621
32Purine metabolism_Homo sapiens_hsa002301.38132067
33Cell cycle_Homo sapiens_hsa041101.33966947
34Base excision repair_Homo sapiens_hsa034101.33710856
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31383689
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26746945
37Biosynthesis of amino acids_Homo sapiens_hsa012301.24870643
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22935056
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17740657
40Sulfur relay system_Homo sapiens_hsa041221.17356232
41Butanoate metabolism_Homo sapiens_hsa006501.11438330
42Fatty acid degradation_Homo sapiens_hsa000711.10181819
43Fanconi anemia pathway_Homo sapiens_hsa034601.08672793
44Peroxisome_Homo sapiens_hsa041461.06543273
45Folate biosynthesis_Homo sapiens_hsa007901.04247349
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.04000992
47Nitrogen metabolism_Homo sapiens_hsa009100.96999086
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90981553
49Metabolic pathways_Homo sapiens_hsa011000.90341465
50Non-homologous end-joining_Homo sapiens_hsa034500.90286487
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87212675
52Fatty acid elongation_Homo sapiens_hsa000620.87004455
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84808736
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.84501746
55beta-Alanine metabolism_Homo sapiens_hsa004100.81449127
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80499221
57Vitamin B6 metabolism_Homo sapiens_hsa007500.80018967
58Glutathione metabolism_Homo sapiens_hsa004800.77783305
59Phenylalanine metabolism_Homo sapiens_hsa003600.72703438
60Arginine and proline metabolism_Homo sapiens_hsa003300.72585765
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72127817
62Sulfur metabolism_Homo sapiens_hsa009200.70612249
63Tyrosine metabolism_Homo sapiens_hsa003500.69179788
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68393873
65Fatty acid metabolism_Homo sapiens_hsa012120.67389740
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.64337841
67Pentose phosphate pathway_Homo sapiens_hsa000300.63705959
68mRNA surveillance pathway_Homo sapiens_hsa030150.63369912
69Tryptophan metabolism_Homo sapiens_hsa003800.61960172
70GABAergic synapse_Homo sapiens_hsa047270.59937165
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55279100
72Oocyte meiosis_Homo sapiens_hsa041140.53447684
73Selenocompound metabolism_Homo sapiens_hsa004500.53163970
74Arginine biosynthesis_Homo sapiens_hsa002200.52592549
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51379973
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51240911
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48367133
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48148020
79Taste transduction_Homo sapiens_hsa047420.47729738
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44222905
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44010888
82Regulation of autophagy_Homo sapiens_hsa041400.43484242
83Morphine addiction_Homo sapiens_hsa050320.42847107
84Nicotine addiction_Homo sapiens_hsa050330.42342101
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41726534
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.41579591
87Caffeine metabolism_Homo sapiens_hsa002320.40498036
88Olfactory transduction_Homo sapiens_hsa047400.40396884
89Chemical carcinogenesis_Homo sapiens_hsa052040.39376995
90Epstein-Barr virus infection_Homo sapiens_hsa051690.38584514
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38222779
92Synaptic vesicle cycle_Homo sapiens_hsa047210.37226981
93Circadian rhythm_Homo sapiens_hsa047100.36556677
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36292061
95Starch and sucrose metabolism_Homo sapiens_hsa005000.35809929
96p53 signaling pathway_Homo sapiens_hsa041150.33460241
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32501276
98Serotonergic synapse_Homo sapiens_hsa047260.32326686
99Retinol metabolism_Homo sapiens_hsa008300.29614060
100Collecting duct acid secretion_Homo sapiens_hsa049660.29244003
101Linoleic acid metabolism_Homo sapiens_hsa005910.28302736
102Circadian entrainment_Homo sapiens_hsa047130.26702833
103Glutamatergic synapse_Homo sapiens_hsa047240.25595114
104Histidine metabolism_Homo sapiens_hsa003400.25157187
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.23720566
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20721315
107Phototransduction_Homo sapiens_hsa047440.20139397
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18244393
109Alcoholism_Homo sapiens_hsa050340.17985954
110Galactose metabolism_Homo sapiens_hsa000520.17359569
111Fructose and mannose metabolism_Homo sapiens_hsa000510.16745391
112Steroid biosynthesis_Homo sapiens_hsa001000.16058628
113Glucagon signaling pathway_Homo sapiens_hsa049220.15147927
114Systemic lupus erythematosus_Homo sapiens_hsa053220.13738677
115Arachidonic acid metabolism_Homo sapiens_hsa005900.12213171
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11752591

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