ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	9.18155322
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.80048905
3	regulation of memory T cell differentiation (GO:0043380)	6.04594900
4	L-fucose metabolic process (GO:0042354)	5.83334296
5	L-fucose catabolic process (GO:0042355)	5.83334296
6	fucose catabolic process (GO:0019317)	5.83334296
7	ADP metabolic process (GO:0046031)	5.54440162
8	transcription from mitochondrial promoter (GO:0006390)	5.10713341
9	protein polyglutamylation (GO:0018095)	4.99959774
10	positive regulation of mitochondrial fission (GO:0090141)	4.96323774
11	proteasome assembly (GO:0043248)	4.91580130
12	regulation of cilium movement (GO:0003352)	4.88129361
13	cilium or flagellum-dependent cell motility (GO:0001539)	4.86202874
14	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	4.86004915
15	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.80719135
16	regulation of activation of Janus kinase activity (GO:0010533)	4.48504105
17	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	4.33498303
18	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	4.20822946
19	positive regulation of defense response to virus by host (GO:0002230)	4.18973085
20	neuron fate determination (GO:0048664)	3.90012806
21	male meiosis (GO:0007140)	3.84730689
22	negative regulation of interleukin-10 production (GO:0032693)	3.83504499
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.68447638
24	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.68447638
25	positive regulation of cell fate commitment (GO:0010455)	3.67962423
26	regulation of mitochondrial fission (GO:0090140)	3.57755466
27	hair cycle (GO:0042633)	3.55924942
28	molting cycle (GO:0042303)	3.55924942
29	rRNA catabolic process (GO:0016075)	3.54159910
30	regulation of hexokinase activity (GO:1903299)	3.52725116
31	regulation of glucokinase activity (GO:0033131)	3.52725116
32	positive regulation of protein homooligomerization (GO:0032464)	3.50772708
33	platelet dense granule organization (GO:0060155)	3.45817699
34	regulation of B cell receptor signaling pathway (GO:0050855)	3.45324665
35	sulfur amino acid catabolic process (GO:0000098)	3.43660454
36	negative regulation of mast cell activation (GO:0033004)	3.43645192
37	positive regulation of interleukin-17 production (GO:0032740)	3.41859691
38	somite development (GO:0061053)	3.40304969
39	epithelial cilium movement (GO:0003351)	3.35534904
40	positive regulation of prostaglandin secretion (GO:0032308)	3.34999305
41	regulation of penile erection (GO:0060405)	3.33858974
42	purine deoxyribonucleotide metabolic process (GO:0009151)	3.32373417
43	tyrosine phosphorylation of STAT protein (GO:0007260)	3.30766727
44	respiratory chain complex IV assembly (GO:0008535)	3.27912571
45	forebrain neuron differentiation (GO:0021879)	3.25517372
46	lipopolysaccharide biosynthetic process (GO:0009103)	3.25420784
47	protein targeting to Golgi (GO:0000042)	3.21056066
48	establishment of protein localization to Golgi (GO:0072600)	3.18537177
49	sequestering of actin monomers (GO:0042989)	3.16484501
50	cellular response to nicotine (GO:0071316)	3.15390958
51	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.14858038
52	protein-chromophore linkage (GO:0018298)	3.11430248
53	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	3.11201520
54	regulation of protein glycosylation (GO:0060049)	3.08690262
55	nephron epithelium morphogenesis (GO:0072088)	3.07851465
56	nephron tubule morphogenesis (GO:0072078)	3.07851465
57	piRNA metabolic process (GO:0034587)	3.04935285
58	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	3.00758684
59	regulation of microtubule-based movement (GO:0060632)	2.99232128
60	N-glycan processing (GO:0006491)	2.98014276
61	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.95759497
62	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.94087649
63	positive regulation of T-helper 1 type immune response (GO:0002827)	2.87127864
64	negative regulation of translational initiation (GO:0045947)	2.84723311
65	labyrinthine layer development (GO:0060711)	2.83769373
66	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.82365625
67	cilium morphogenesis (GO:0060271)	2.82207789
68	regulation of feeding behavior (GO:0060259)	2.81301187
69	purine nucleoside diphosphate metabolic process (GO:0009135)	2.80895833
70	purine ribonucleoside diphosphate metabolic process (GO:0009179)	2.80895833
71	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.78587040
72	cytochrome complex assembly (GO:0017004)	2.77774095
73	detection of light stimulus involved in sensory perception (GO:0050962)	2.74574793
74	detection of light stimulus involved in visual perception (GO:0050908)	2.74574793
75	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.72568516
76	mitochondrial RNA metabolic process (GO:0000959)	2.72247320
77	regulation of growth hormone secretion (GO:0060123)	2.72194611
78	regulation of defense response to virus by host (GO:0050691)	2.71129637
79	protein localization to cilium (GO:0061512)	2.70142068
80	protein complex biogenesis (GO:0070271)	2.69993898
81	activated T cell proliferation (GO:0050798)	2.69691063
82	gamma-aminobutyric acid transport (GO:0015812)	2.66933431
83	protein localization to Golgi apparatus (GO:0034067)	2.66487913
84	coenzyme catabolic process (GO:0009109)	2.65385512
85	positive regulation of developmental pigmentation (GO:0048087)	2.65267567
86	fucose metabolic process (GO:0006004)	2.65228042
87	left/right axis specification (GO:0070986)	2.65024124
88	fucosylation (GO:0036065)	2.63683853
89	intraciliary transport (GO:0042073)	2.63299882
90	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.61723245
91	lipopolysaccharide metabolic process (GO:0008653)	2.61614852
92	regulation of prostaglandin secretion (GO:0032306)	2.61135866
93	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.60709370
94	hindbrain development (GO:0030902)	2.57646870
95	pyrimidine dimer repair (GO:0006290)	2.56747411
96	organelle disassembly (GO:1903008)	2.56649004
97	nucleoside diphosphate phosphorylation (GO:0006165)	2.55947098
98	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.54512710
99	RNA destabilization (GO:0050779)	2.53763870
100	C4-dicarboxylate transport (GO:0015740)	2.52856091

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	5.49201114
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.10627698
3	VDR_22108803_ChIP-Seq_LS180_Human	3.68691377
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08513744
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.89560473
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.76816354
7	FUS_26573619_Chip-Seq_HEK293_Human	2.71462673
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.70363662
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54091342
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.39484721
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30801601
12	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.26318509
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.16939890
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.15447151
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06051723
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03330166
17	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.98786514
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.95959810
19	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.89990255
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81675945
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.75471748
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.72885721
23	EWS_26573619_Chip-Seq_HEK293_Human	1.69599260
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.67857072
25	P300_19829295_ChIP-Seq_ESCs_Human	1.67023515
26	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.66506774
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.64811992
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64811992
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.63146850
30	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.62449824
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.60593934
32	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.60067659
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59287840
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58751377
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.57528070
36	GATA3_26560356_Chip-Seq_TH2_Human	1.55063920
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55056316
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53599520
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50149056
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.49976649
41	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.45165848
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.41204497
43	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.40294958
44	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.39051127
45	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.36544836
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35843640
47	GBX2_23144817_ChIP-Seq_PC3_Human	1.35811787
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.32549782
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30707339
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28902003
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28902003
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28388933
53	CDX2_22108803_ChIP-Seq_LS180_Human	1.26964047
54	STAT3_23295773_ChIP-Seq_U87_Human	1.26850016
55	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.25804967
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25066727
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24971356
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.24794809
59	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24498783
60	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.24326779
61	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.22392711
62	SMAD4_21799915_ChIP-Seq_A2780_Human	1.21976844
63	NCOR_22424771_ChIP-Seq_293T_Human	1.21523941
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20989029
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20989029
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20898279
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17794700
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17113249
69	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.16638622
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16626754
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14247714
72	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.13903243
73	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13450263
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.13381147
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12615997
76	ELK1_19687146_ChIP-ChIP_HELA_Human	1.12578405
77	AR_20517297_ChIP-Seq_VCAP_Human	1.11949462
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11545482
79	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11145517
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10610653
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09722840
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07127925
83	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.04923038
84	VDR_24787735_ChIP-Seq_THP-1_Human	1.01802467
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01551707
86	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.01534352
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01417408
88	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01110116
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01088205
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00601768
91	AR_25329375_ChIP-Seq_VCAP_Human	0.98884971
92	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98053122
93	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.97805944
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97584843
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96942226
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.96318917
97	TCF4_23295773_ChIP-Seq_U87_Human	0.95913262
98	MYC_18940864_ChIP-ChIP_HL60_Human	0.94438478
99	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.92684099
100	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92358571

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.83728061
2	MP0002234_abnormal_pharynx_morphology	4.83600409
3	MP0006292_abnormal_olfactory_placode	4.48047388
4	MP0002102_abnormal_ear_morphology	4.17650084
5	MP0001986_abnormal_taste_sensitivity	3.62385612
6	MP0003787_abnormal_imprinting	3.48468593
7	MP0003195_calcinosis	3.04648213
8	MP0002138_abnormal_hepatobiliary_system	2.94673454
9	MP0002638_abnormal_pupillary_reflex	2.89165154
10	MP0003183_abnormal_peptide_metabolism	2.66383019
11	MP0008789_abnormal_olfactory_epithelium	2.57230770
12	MP0003136_yellow_coat_color	2.57192357
13	MP0004885_abnormal_endolymph	2.47857158
14	MP0000678_abnormal_parathyroid_gland	2.36468677
15	MP0001879_abnormal_lymphatic_vessel	2.25403510
16	MP0005394_taste/olfaction_phenotype	2.21518122
17	MP0005499_abnormal_olfactory_system	2.21518122
18	MP0005075_abnormal_melanosome_morpholog	2.18812765
19	MP0002653_abnormal_ependyma_morphology	2.01438799
20	MP0005084_abnormal_gallbladder_morpholo	1.93484577
21	MP0003283_abnormal_digestive_organ	1.90505715
22	MP0006276_abnormal_autonomic_nervous	1.86262416
23	MP0008995_early_reproductive_senescence	1.84630720
24	MP0006072_abnormal_retinal_apoptosis	1.82982263
25	MP0000049_abnormal_middle_ear	1.80205869
26	MP0005670_abnormal_white_adipose	1.79603081
27	MP0002282_abnormal_trachea_morphology	1.63874244
28	MP0001188_hyperpigmentation	1.61312485
29	MP0004145_abnormal_muscle_electrophysio	1.46370619
30	MP0003121_genomic_imprinting	1.40271279
31	MP0003866_abnormal_defecation	1.37019410
32	MP0003938_abnormal_ear_development	1.35317264
33	MP0001485_abnormal_pinna_reflex	1.35070278
34	MP0005167_abnormal_blood-brain_barrier	1.35069948
35	MP0000383_abnormal_hair_follicle	1.29411839
36	MP0008775_abnormal_heart_ventricle	1.26983425
37	MP0005551_abnormal_eye_electrophysiolog	1.25690760
38	MP0000372_irregular_coat_pigmentation	1.13790598
39	MP0001764_abnormal_homeostasis	1.12620934
40	MP0002938_white_spotting	1.06739014
41	MP0006036_abnormal_mitochondrial_physio	1.06108812
42	MP0003567_abnormal_fetal_cardiomyocyte	1.04259147
43	MP0005671_abnormal_response_to	1.02463787
44	MP0001963_abnormal_hearing_physiology	1.02346626
45	MP0004147_increased_porphyrin_level	1.00607604
46	MP0000427_abnormal_hair_cycle	0.96936003
47	MP0005253_abnormal_eye_physiology	0.96392427
48	MP0000631_abnormal_neuroendocrine_gland	0.96085491
49	MP0009780_abnormal_chondrocyte_physiolo	0.95450132
50	MP0004142_abnormal_muscle_tone	0.95027606
51	MP0003786_premature_aging	0.94635595
52	MP0000026_abnormal_inner_ear	0.94510938
53	MP0008872_abnormal_physiological_respon	0.93600776
54	MP0004133_heterotaxia	0.90028374
55	MP0002928_abnormal_bile_duct	0.88082924
56	MP0003186_abnormal_redox_activity	0.87962910
57	MP0002736_abnormal_nociception_after	0.86304725
58	MP0010368_abnormal_lymphatic_system	0.84731311
59	MP0008875_abnormal_xenobiotic_pharmacok	0.83512790
60	MP0001299_abnormal_eye_distance/	0.83425899
61	MP0004215_abnormal_myocardial_fiber	0.81387143
62	MP0002090_abnormal_vision	0.80850750
63	MP0002332_abnormal_exercise_endurance	0.80053721
64	MP0003122_maternal_imprinting	0.79653891
65	MP0006035_abnormal_mitochondrial_morpho	0.78461862
66	MP0000703_abnormal_thymus_morphology	0.78142793
67	MP0001968_abnormal_touch/_nociception	0.78121012
68	MP0009046_muscle_twitch	0.76988767
69	MP0002132_abnormal_respiratory_system	0.76944253
70	MP0000647_abnormal_sebaceous_gland	0.76757717
71	MP0002177_abnormal_outer_ear	0.74627202
72	MP0000613_abnormal_salivary_gland	0.73512345
73	MP0001765_abnormal_ion_homeostasis	0.73419001
74	MP0002693_abnormal_pancreas_physiology	0.72318899
75	MP0002139_abnormal_hepatobiliary_system	0.70973797
76	MP0003646_muscle_fatigue	0.70852961
77	MP0009333_abnormal_splenocyte_physiolog	0.70018843
78	MP0004742_abnormal_vestibular_system	0.69600330
79	MP0003633_abnormal_nervous_system	0.69348619
80	MP0005645_abnormal_hypothalamus_physiol	0.68612056
81	MP0008057_abnormal_DNA_replication	0.68314628
82	MP0010678_abnormal_skin_adnexa	0.68119102
83	MP0005195_abnormal_posterior_eye	0.67623471
84	MP0001800_abnormal_humoral_immune	0.66223188
85	MP0009785_altered_susceptibility_to	0.64977245
86	MP0002277_abnormal_respiratory_mucosa	0.63879196
87	MP0000681_abnormal_thyroid_gland	0.63563178
88	MP0002837_dystrophic_cardiac_calcinosis	0.62451968
89	MP0002735_abnormal_chemical_nociception	0.61112584
90	MP0003045_fibrosis	0.61094152
91	MP0000778_abnormal_nervous_system	0.59747274
92	MP0002272_abnormal_nervous_system	0.59361008
93	MP0002229_neurodegeneration	0.57312780
94	MP0005083_abnormal_biliary_tract	0.57231830
95	MP0003879_abnormal_hair_cell	0.57182076
96	MP0003878_abnormal_ear_physiology	0.57064313
97	MP0005377_hearing/vestibular/ear_phenot	0.57064313
98	MP0000653_abnormal_sex_gland	0.56835664
99	MP0003698_abnormal_male_reproductive	0.54319185
100	MP0002751_abnormal_autonomic_nervous	0.53998333

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypothermia (HP:0002045)	4.40742910
2	Prominent metopic ridge (HP:0005487)	4.37271655
3	Abnormality of the metopic suture (HP:0005556)	4.02826409
4	Atonic seizures (HP:0010819)	4.01436924
5	Nephronophthisis (HP:0000090)	3.94206581
6	Autoimmune hemolytic anemia (HP:0001890)	3.89067363
7	Optic neuritis (HP:0100653)	3.72753921
8	Retrobulbar optic neuritis (HP:0100654)	3.72753921
9	Hypoplasia of the uterus (HP:0000013)	3.59597512
10	Abnormality of midbrain morphology (HP:0002418)	3.49408635
11	Molar tooth sign on MRI (HP:0002419)	3.49408635
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.29400217
13	Absent/shortened dynein arms (HP:0200106)	3.29400217
14	Severe combined immunodeficiency (HP:0004430)	3.25587958
15	Chronic hepatic failure (HP:0100626)	3.22419534
16	Hip dysplasia (HP:0001385)	3.22248326
17	Pancreatic fibrosis (HP:0100732)	3.15606097
18	Disproportionate short-trunk short stature (HP:0003521)	3.13193683
19	Orchitis (HP:0100796)	3.03244889
20	Hypophosphatemic rickets (HP:0004912)	3.01603830
21	True hermaphroditism (HP:0010459)	2.97097662
22	Stenosis of the external auditory canal (HP:0000402)	2.91037726
23	Abnormality of the renal medulla (HP:0100957)	2.90660066
24	Metaphyseal dysplasia (HP:0100255)	2.86399266
25	Thyroiditis (HP:0100646)	2.85363313
26	Aplasia/hypoplasia of the uterus (HP:0008684)	2.84453175
27	Late onset (HP:0003584)	2.81315665
28	Myositis (HP:0100614)	2.69514532
29	Tented upper lip vermilion (HP:0010804)	2.66625808
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.65052310
31	Abnormal respiratory motile cilium morphology (HP:0005938)	2.65052310
32	Stomatitis (HP:0010280)	2.64624024
33	Tubular atrophy (HP:0000092)	2.64530305
34	Enlarged epiphyses (HP:0010580)	2.64133359
35	Abnormality of lateral ventricle (HP:0030047)	2.61411756
36	Pancreatic cysts (HP:0001737)	2.53099989
37	Dyskinesia (HP:0100660)	2.46796437
38	Postaxial foot polydactyly (HP:0001830)	2.43669279
39	Combined immunodeficiency (HP:0005387)	2.37410806
40	Alveolar cell carcinoma (HP:0006519)	2.32395953
41	Abnormality of the renal cortex (HP:0011035)	2.31524018
42	Pachygyria (HP:0001302)	2.27853793
43	Papilledema (HP:0001085)	2.24316428
44	Palpebral edema (HP:0100540)	2.22155616
45	Keratoconjunctivitis sicca (HP:0001097)	2.20552986
46	Hyperinsulinemic hypoglycemia (HP:0000825)	2.12939802
47	Hypoplastic ischia (HP:0003175)	2.10057703
48	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08972476
49	Thyroid-stimulating hormone excess (HP:0002925)	2.03700183
50	Abnormality of the antihelix (HP:0009738)	2.03183563
51	Neonatal respiratory distress (HP:0002643)	2.01721253
52	Abolished electroretinogram (ERG) (HP:0000550)	2.01647101
53	Esophageal atresia (HP:0002032)	2.00987317
54	Hypochromic microcytic anemia (HP:0004840)	2.00841493
55	Keratoconjunctivitis (HP:0001096)	1.98186478
56	Stage 5 chronic kidney disease (HP:0003774)	1.97887716
57	Type I transferrin isoform profile (HP:0003642)	1.97445681
58	Hypoglycemic coma (HP:0001325)	1.96762190
59	Facial diplegia (HP:0001349)	1.95495948
60	Deep palmar crease (HP:0006191)	1.95164086
61	Elevated erythrocyte sedimentation rate (HP:0003565)	1.94635716
62	Abnormal ciliary motility (HP:0012262)	1.93861782
63	Drooling (HP:0002307)	1.93399509
64	Abnormality of eosinophils (HP:0001879)	1.93041177
65	Medial flaring of the eyebrow (HP:0010747)	1.92356989
66	Congenital stationary night blindness (HP:0007642)	1.91911282
67	Dysdiadochokinesis (HP:0002075)	1.91786468
68	Anosmia (HP:0000458)	1.91629597
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91247483
70	Gastrointestinal atresia (HP:0002589)	1.91128721
71	Vitreoretinal degeneration (HP:0000655)	1.90956012
72	Morphological abnormality of the inner ear (HP:0011390)	1.90317467
73	Shoulder girdle muscle weakness (HP:0003547)	1.89484253
74	Morphological abnormality of the middle ear (HP:0008609)	1.89184651
75	Abnormality of dental color (HP:0011073)	1.84929671
76	Neoplasm of the tracheobronchial system (HP:0100552)	1.84088552
77	Keratitis (HP:0000491)	1.83966021
78	Pancreatic islet-cell hyperplasia (HP:0004510)	1.83538433
79	Sclerocornea (HP:0000647)	1.82550713
80	Submucous cleft hard palate (HP:0000176)	1.81125338
81	Excessive salivation (HP:0003781)	1.76900450
82	Abnormality of hair growth rate (HP:0011363)	1.76267181
83	Slow-growing hair (HP:0002217)	1.76267181
84	Pulmonary embolism (HP:0002204)	1.76170871
85	Absence seizures (HP:0002121)	1.75717550
86	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.74473703
87	Abnormal protein N-linked glycosylation (HP:0012347)	1.74473703
88	Abnormal protein glycosylation (HP:0012346)	1.74473703
89	Abnormal glycosylation (HP:0012345)	1.74473703
90	Polydipsia (HP:0001959)	1.71812460
91	Abnormal drinking behavior (HP:0030082)	1.71812460
92	Pelvic girdle muscle weakness (HP:0003749)	1.71747332
93	Abnormal pancreas size (HP:0012094)	1.70242451
94	Dialeptic seizures (HP:0011146)	1.70043123
95	IgG deficiency (HP:0004315)	1.69315376
96	Gangrene (HP:0100758)	1.68402681
97	Absent eyebrow (HP:0002223)	1.66789503
98	Intellectual disability, moderate (HP:0002342)	1.64590199
99	Hepatocellular necrosis (HP:0001404)	1.64214039
100	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.63998450

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	9.28737498
2	EPHA3	3.55207512
3	PLK2	3.35472054
4	MAP4K2	3.27660784
5	AKT3	2.44912435
6	TXK	2.25518221
7	MAP3K12	2.05567055
8	FRK	1.97723654
9	TEC	1.88307315
10	MUSK	1.88058276
11	ITK	1.84083208
12	BCR	1.68533841
13	CASK	1.67072346
14	SCYL2	1.62673625
15	FER	1.54744429
16	MAPK13	1.52981871
17	ADRBK2	1.51740437
18	TLK1	1.40306243
19	IRAK1	1.39691263
20	PINK1	1.39341840
21	BMPR1B	1.35859592
22	TRIM28	1.25784588
23	MAPKAPK3	1.24123309
24	EIF2AK1	1.22571955
25	TIE1	1.18431580
26	JAK3	1.11125551
27	CAMKK2	1.08053530
28	GRK1	1.04938075
29	CHUK	1.04813461
30	MYLK	1.04026320
31	IKBKB	1.03095650
32	WNK4	1.02682034
33	INSRR	1.01301730
34	ZAK	0.95411012
35	TNIK	0.92660674
36	PRKCE	0.88363341
37	PASK	0.85409893
38	STK38L	0.83248026
39	DYRK2	0.82255903
40	KIT	0.79803898
41	NLK	0.79487474
42	LIMK1	0.76703648
43	CSNK1G2	0.75940072
44	SIK3	0.75523915
45	KDR	0.74967577
46	NUAK1	0.74859314
47	IGF1R	0.74839640
48	RPS6KA5	0.73764204
49	ARAF	0.72717027
50	EPHB1	0.71918317
51	CSNK1A1L	0.70644801
52	VRK1	0.70208831
53	CDK8	0.68618503
54	PTK2B	0.68191392
55	BMPR2	0.66229207
56	LCK	0.66062380
57	CSNK1G3	0.65677136
58	CSNK1G1	0.62899514
59	PIK3CA	0.61084754
60	CSNK1A1	0.60398662
61	TBK1	0.59171477
62	BRSK2	0.58710191
63	PLK4	0.56631215
64	MAPK11	0.55434425
65	MAP3K13	0.55339132
66	PRKCH	0.53791898
67	SGK2	0.51476051
68	TAOK3	0.47686983
69	MATK	0.44738012
70	OXSR1	0.44578695
71	SGK223	0.44237998
72	SGK494	0.44237998
73	GRK7	0.43174703
74	OBSCN	0.43159684
75	RAF1	0.42046768
76	TRPM7	0.40970392
77	BRAF	0.40375884
78	MAP4K1	0.40281954
79	SGK3	0.38964980
80	PRKCI	0.38427407
81	IKBKE	0.37990080
82	WNK1	0.37357688
83	CAMK2A	0.37194416
84	ADRBK1	0.36697754
85	PRKCQ	0.36442019
86	MST4	0.34782702
87	BTK	0.34221079
88	PIM2	0.31592074
89	LYN	0.30332425
90	WNK3	0.29517746
91	ATM	0.29065688
92	CAMKK1	0.28385144
93	ERBB3	0.27786973
94	ILK	0.27091385
95	CSNK1D	0.24688730
96	PRKACA	0.23507974
97	STK39	0.23028954
98	PRKACG	0.22402086
99	MKNK1	0.22174659
100	EEF2K	0.22134962

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	4.27850476
2	Protein export_Homo sapiens_hsa03060	3.16610485
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.60803618
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.56099296
5	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.54954656
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44097473
7	Caffeine metabolism_Homo sapiens_hsa00232	2.37285577
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.26610074
9	Parkinsons disease_Homo sapiens_hsa05012	2.01752370
10	Basal transcription factors_Homo sapiens_hsa03022	1.90364865
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89628792
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.88126365
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.82314319
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.71428918
15	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.71157701
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.63556327
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56260466
18	Collecting duct acid secretion_Homo sapiens_hsa04966	1.51982274
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.42909884
20	ABC transporters_Homo sapiens_hsa02010	1.40342514
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.30186210
22	Asthma_Homo sapiens_hsa05310	1.28763258
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.28423615
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24388594
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.22815665
26	RNA polymerase_Homo sapiens_hsa03020	1.22575415
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.21733770
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19811147
29	Nicotine addiction_Homo sapiens_hsa05033	1.19104261
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.17899701
31	Alzheimers disease_Homo sapiens_hsa05010	1.17193466
32	Measles_Homo sapiens_hsa05162	1.16716193
33	Proteasome_Homo sapiens_hsa03050	1.15959250
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12127797
35	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.12055303
36	Olfactory transduction_Homo sapiens_hsa04740	1.11780869
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.11661647
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.10655122
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.07569583
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.07541683
41	Huntingtons disease_Homo sapiens_hsa05016	1.07223527
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.06990963
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.03809772
44	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.03203862
45	Propanoate metabolism_Homo sapiens_hsa00640	1.01350990
46	Circadian rhythm_Homo sapiens_hsa04710	0.99940719
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.96838127
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95122584
49	Mismatch repair_Homo sapiens_hsa03430	0.93749681
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.93648149
51	Allograft rejection_Homo sapiens_hsa05330	0.93588426
52	Butanoate metabolism_Homo sapiens_hsa00650	0.93502695
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92916602
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.92541258
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92393655
56	Rheumatoid arthritis_Homo sapiens_hsa05323	0.89258875
57	Taste transduction_Homo sapiens_hsa04742	0.89150496
58	RNA transport_Homo sapiens_hsa03013	0.85483245
59	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.83889865
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83282987
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83082607
62	Purine metabolism_Homo sapiens_hsa00230	0.82728896
63	RNA degradation_Homo sapiens_hsa03018	0.80214422
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76634846
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.72588300
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71470513
67	Legionellosis_Homo sapiens_hsa05134	0.70682229
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69515864
69	One carbon pool by folate_Homo sapiens_hsa00670	0.69383719
70	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.65979079
71	Alcoholism_Homo sapiens_hsa05034	0.64773621
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64283677
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64224667
74	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.64197470
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62092993
76	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.61279666
77	Peroxisome_Homo sapiens_hsa04146	0.60166621
78	Spliceosome_Homo sapiens_hsa03040	0.60106770
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.59030780
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57298967
81	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.56750297
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.54227081
83	Serotonergic synapse_Homo sapiens_hsa04726	0.54003712
84	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53971084
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.53155701
86	Herpes simplex infection_Homo sapiens_hsa05168	0.51399188
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50264278
88	Metabolic pathways_Homo sapiens_hsa01100	0.49823537
89	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.49781917
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49493897
91	Retinol metabolism_Homo sapiens_hsa00830	0.49480064
92	Renin-angiotensin system_Homo sapiens_hsa04614	0.44472290
93	Long-term depression_Homo sapiens_hsa04730	0.42680835
94	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.42420075
95	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.41919816
96	Fatty acid elongation_Homo sapiens_hsa00062	0.40880009
97	Regulation of autophagy_Homo sapiens_hsa04140	0.39752501
98	Oocyte meiosis_Homo sapiens_hsa04114	0.38078179
99	Thyroid cancer_Homo sapiens_hsa05216	0.37844481
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.37476971

NDUFAF4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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