NDUFAF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an assembly factor protein which helps in the assembly and stabilization of Complex I, a large multi-subunit enzyme in the mitochondrial respiratory chain. Complex I is involved in several physiological activities in the cell, including metabolite transport and ATP synthesis. The encoded protein is a methyltransferase which methylates Arg85 of a subunit of Complex I in the early stages of its assembly. A pseudogene related to this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitochondrial calcium ion concentration (GO:0051561)6.16512075
2mitochondrial calcium ion transport (GO:0006851)6.11197079
3cellular protein complex localization (GO:0034629)5.20899541
4cullin deneddylation (GO:0010388)4.90052645
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.79667499
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.77702571
7protein deneddylation (GO:0000338)4.59682195
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.53783716
9ATP synthesis coupled proton transport (GO:0015986)4.53783716
10chaperone-mediated protein transport (GO:0072321)4.39774608
11neuron cell-cell adhesion (GO:0007158)4.35044838
12protein neddylation (GO:0045116)4.19599128
13* protein complex biogenesis (GO:0070271)4.18778059
14proteasome assembly (GO:0043248)4.16246228
15protein complex localization (GO:0031503)4.07541569
16respiratory electron transport chain (GO:0022904)4.05039537
17vitamin transmembrane transport (GO:0035461)4.03941648
18* mitochondrial respiratory chain complex I assembly (GO:0032981)3.99247466
19* NADH dehydrogenase complex assembly (GO:0010257)3.99247466
20* mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99247466
21termination of RNA polymerase III transcription (GO:0006386)3.97790786
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.97790786
23electron transport chain (GO:0022900)3.97686265
24presynaptic membrane assembly (GO:0097105)3.96607251
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.95640643
26regulation of mitotic spindle checkpoint (GO:1903504)3.95640643
27chromatin remodeling at centromere (GO:0031055)3.91314409
28maturation of 5.8S rRNA (GO:0000460)3.90608768
29mitochondrial calcium ion homeostasis (GO:0051560)3.82893831
30* mitochondrial respiratory chain complex assembly (GO:0033108)3.77957229
31protein-cofactor linkage (GO:0018065)3.77275238
32DNA double-strand break processing (GO:0000729)3.77201521
33pyrimidine-containing compound transmembrane transport (GO:0072531)3.70010194
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.66899015
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.66883156
36CENP-A containing nucleosome assembly (GO:0034080)3.64246466
377-methylguanosine mRNA capping (GO:0006370)3.64187170
38RNA capping (GO:0036260)3.62633093
397-methylguanosine RNA capping (GO:0009452)3.62633093
40DNA strand elongation involved in DNA replication (GO:0006271)3.58601997
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.55368379
42L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53029406
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.52623788
44somatic diversification of immune receptors via somatic mutation (GO:0002566)3.52623788
45GTP biosynthetic process (GO:0006183)3.51453107
46presynaptic membrane organization (GO:0097090)3.50011114
47establishment of integrated proviral latency (GO:0075713)3.49798609
48regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.49471469
49mitochondrial RNA metabolic process (GO:0000959)3.48665301
50telomere maintenance via semi-conservative replication (GO:0032201)3.48375360
51guanosine-containing compound biosynthetic process (GO:1901070)3.42923146
52regulation of mitochondrial translation (GO:0070129)3.39208864
53DNA strand elongation (GO:0022616)3.37822538
54water-soluble vitamin biosynthetic process (GO:0042364)3.31473406
55L-serine metabolic process (GO:0006563)3.30146197
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.29127766
57response to pheromone (GO:0019236)3.27806084
58nucleobase biosynthetic process (GO:0046112)3.25979086
59regulation of coenzyme metabolic process (GO:0051196)3.23543717
60regulation of cofactor metabolic process (GO:0051193)3.23543717
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21737476
62ribosome assembly (GO:0042255)3.20672624
63respiratory chain complex IV assembly (GO:0008535)3.20356788
64DNA integration (GO:0015074)3.20329452
65pseudouridine synthesis (GO:0001522)3.18891114
66histone exchange (GO:0043486)3.16304585
67transcription elongation from RNA polymerase I promoter (GO:0006362)3.14500308
68DNA replication-dependent nucleosome organization (GO:0034723)3.13501531
69DNA replication-dependent nucleosome assembly (GO:0006335)3.13501531
70dopamine transport (GO:0015872)3.11777656
71cytochrome complex assembly (GO:0017004)3.10768656
72positive regulation of mitochondrial fission (GO:0090141)3.10501476
73regulation of cellular amino acid metabolic process (GO:0006521)3.08759288
74attachment of spindle microtubules to kinetochore (GO:0008608)3.08090422
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07004573
76DNA replication checkpoint (GO:0000076)3.06326780
77IMP biosynthetic process (GO:0006188)3.04674089
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04295202
79regulation of centriole replication (GO:0046599)3.02703526
80protein localization to kinetochore (GO:0034501)3.01595342
81vocalization behavior (GO:0071625)3.00658744
82telomere maintenance via recombination (GO:0000722)3.00551434
83regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.96802837
84regulation of centrosome cycle (GO:0046605)2.96486555
85peptidyl-arginine omega-N-methylation (GO:0035247)2.95613034
86regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95209914
87branched-chain amino acid catabolic process (GO:0009083)2.95029441
88amino acid salvage (GO:0043102)2.94587469
89L-methionine salvage (GO:0071267)2.94587469
90L-methionine biosynthetic process (GO:0071265)2.94587469
91protein targeting to mitochondrion (GO:0006626)2.93632974
92NADH metabolic process (GO:0006734)2.93599936
93histone arginine methylation (GO:0034969)2.90878050
94postsynaptic membrane organization (GO:0001941)2.90163595
95termination of RNA polymerase I transcription (GO:0006363)2.89800113
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88371848
97negative regulation of ligase activity (GO:0051352)2.88371848
98protein K6-linked ubiquitination (GO:0085020)2.87037373
99nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.87026440
100mitotic recombination (GO:0006312)2.85802037
101replication fork processing (GO:0031297)2.85483706
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85357691
103mitotic G2/M transition checkpoint (GO:0044818)2.84376840
104telomere maintenance via telomere lengthening (GO:0010833)2.83575740
105ATP hydrolysis coupled proton transport (GO:0015991)2.83544525
106energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83544525
107behavioral response to nicotine (GO:0035095)2.83327592
108establishment of protein localization to mitochondrion (GO:0072655)2.83225954
109DNA catabolic process, exonucleolytic (GO:0000738)2.82597221
110UTP biosynthetic process (GO:0006228)2.82027293
111magnesium ion transport (GO:0015693)2.78431753
112oxidative phosphorylation (GO:0006119)2.77315123
113ubiquinone biosynthetic process (GO:0006744)2.77205634
114quinone biosynthetic process (GO:1901663)2.77205634
115positive regulation of protein homodimerization activity (GO:0090073)2.76966520
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76871513
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76871513
118startle response (GO:0001964)2.76011403
119negative regulation of dendrite morphogenesis (GO:0050774)2.75717878
120histone mRNA metabolic process (GO:0008334)2.75305994
121resolution of meiotic recombination intermediates (GO:0000712)2.74088937
122inner mitochondrial membrane organization (GO:0007007)2.73140313
123homocysteine metabolic process (GO:0050667)2.73132442
124transcription from RNA polymerase I promoter (GO:0006360)2.73085984
125intraciliary transport (GO:0042073)2.73044284
126DNA replication-independent nucleosome assembly (GO:0006336)2.72186601
127DNA replication-independent nucleosome organization (GO:0034724)2.72186601
128DNA damage response, detection of DNA damage (GO:0042769)2.71408765
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.70096295
130negative regulation of sister chromatid segregation (GO:0033046)2.70096295
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.70096295
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70096295
133negative regulation of mitotic sister chromatid segregation (GO:0033048)2.70096295
134DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69906080
135transferrin transport (GO:0033572)2.69198789
136positive regulation of synapse assembly (GO:0051965)2.68590271
137protein localization to mitochondrion (GO:0070585)2.68228471
138IMP metabolic process (GO:0046040)2.67311379
139purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66804065
140neurotransmitter-gated ion channel clustering (GO:0072578)2.66426212
141signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66280978
142signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66280978
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66280978
144regulation of acyl-CoA biosynthetic process (GO:0050812)2.65391539
145peptidyl-arginine N-methylation (GO:0035246)2.65039406
146peptidyl-arginine methylation (GO:0018216)2.65039406
147negative regulation of DNA recombination (GO:0045910)2.64559261
148positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64158325
149purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64077802
150neuron-neuron synaptic transmission (GO:0007270)2.63600207
151signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63006480
152intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63006480
153negative regulation of chromosome segregation (GO:0051985)2.62762605
154microtubule depolymerization (GO:0007019)2.61152850
155gamma-aminobutyric acid signaling pathway (GO:0007214)2.61090851
156alternative mRNA splicing, via spliceosome (GO:0000380)2.60976907
157ubiquinone metabolic process (GO:0006743)2.60975211
158mitotic spindle checkpoint (GO:0071174)2.60943235
159mannosylation (GO:0097502)2.60896768
160metallo-sulfur cluster assembly (GO:0031163)2.60670075
161iron-sulfur cluster assembly (GO:0016226)2.60670075
162hydrogen ion transmembrane transport (GO:1902600)2.59970806
163protein localization to synapse (GO:0035418)2.59912756
164signal transduction involved in cell cycle checkpoint (GO:0072395)2.58709610
165serotonin receptor signaling pathway (GO:0007210)2.58140726
166nucleotide-excision repair, DNA gap filling (GO:0006297)2.58123220
167spindle checkpoint (GO:0031577)2.57762768
168rRNA modification (GO:0000154)2.55972613
169signal transduction involved in DNA integrity checkpoint (GO:0072401)2.55620695
170signal transduction involved in DNA damage checkpoint (GO:0072422)2.55620695
171GMP metabolic process (GO:0046037)2.53585440
172positive regulation of ligase activity (GO:0051351)2.51506503
173transcription elongation from RNA polymerase II promoter (GO:0006368)2.49584443
174transcription initiation from RNA polymerase I promoter (GO:0006361)2.48982415
175purine nucleobase biosynthetic process (GO:0009113)2.48958703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98534748
2E2F7_22180533_ChIP-Seq_HELA_Human3.89118318
3GBX2_23144817_ChIP-Seq_PC3_Human3.23935952
4TAF15_26573619_Chip-Seq_HEK293_Human3.13097617
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09311335
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07753210
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01988214
8EZH2_22144423_ChIP-Seq_EOC_Human2.95434111
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.92610463
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90565873
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81455699
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.75600071
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64900494
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59400756
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41603430
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33897031
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.32196747
18ZNF274_21170338_ChIP-Seq_K562_Hela2.29399826
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.29157186
20VDR_22108803_ChIP-Seq_LS180_Human2.23918886
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23016125
22IGF1R_20145208_ChIP-Seq_DFB_Human2.21436039
23FUS_26573619_Chip-Seq_HEK293_Human1.99817060
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97933714
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94240628
26MYC_18940864_ChIP-ChIP_HL60_Human1.92196623
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91291528
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89584213
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.89449922
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88226637
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84477143
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.84110967
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81617095
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80845896
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.77873296
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75582381
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.75198216
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72545984
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70271124
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67132294
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65519765
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63185486
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62867984
44P300_19829295_ChIP-Seq_ESCs_Human1.59368819
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54035669
46VDR_23849224_ChIP-Seq_CD4+_Human1.50797233
47EWS_26573619_Chip-Seq_HEK293_Human1.46604386
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45755912
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.44907106
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44296212
51IRF1_19129219_ChIP-ChIP_H3396_Human1.44245669
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41919200
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.41533301
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.40464918
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40063092
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37393945
57DCP1A_22483619_ChIP-Seq_HELA_Human1.36967357
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36637600
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33637574
60ER_23166858_ChIP-Seq_MCF-7_Human1.33073048
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32081366
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.31887994
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31057105
64RNF2_27304074_Chip-Seq_NSC_Mouse1.31011822
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30327202
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.29780496
67ELK1_19687146_ChIP-ChIP_HELA_Human1.29310727
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28158277
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.28123583
70FOXP3_21729870_ChIP-Seq_TREG_Human1.27437954
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25239617
72SMAD4_21799915_ChIP-Seq_A2780_Human1.24502708
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23915326
74XRN2_22483619_ChIP-Seq_HELA_Human1.22594155
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22087591
76REST_21632747_ChIP-Seq_MESCs_Mouse1.21742601
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20603180
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19271512
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19007908
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18989961
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18098382
82TP53_22573176_ChIP-Seq_HFKS_Human1.17518016
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17316309
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16749665
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16595499
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16533467
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16279800
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16087237
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14199301
90JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13276377
91AR_21909140_ChIP-Seq_LNCAP_Human1.12550927
92MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12312114
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.11901849
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.11504750
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.11029743
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10629989
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.09456129
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09325217
99P53_22387025_ChIP-Seq_ESCs_Mouse1.08599584
100JUN_21703547_ChIP-Seq_K562_Human1.08525677
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07978555
102E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07856375
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07848447
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.07640408
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.07226458
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06860497
107SOX9_26525672_Chip-Seq_HEART_Mouse1.06678000
108EED_16625203_ChIP-ChIP_MESCs_Mouse1.06581911
109SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06333749
110CIITA_25753668_ChIP-Seq_RAJI_Human1.04998882
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.04223246
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03653594
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03093463
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03086720
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02261864
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.01483205
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00862802
118REST_18959480_ChIP-ChIP_MESCs_Mouse0.99744339
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99021437
120GABP_19822575_ChIP-Seq_HepG2_Human0.97723155
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97682162
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97283348
123TTF2_22483619_ChIP-Seq_HELA_Human0.96245078
124SOX2_18555785_Chip-Seq_ESCs_Mouse0.95277795
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95264105
126PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95248787
127RUNX1_27457419_Chip-Seq_LIVER_Mouse0.94640880
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94451115
129P300_18555785_Chip-Seq_ESCs_Mouse0.94307616
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93439290
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93104118
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.92500622
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92155265
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.91632077
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89825236
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89811988
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89590782
138CBP_20019798_ChIP-Seq_JUKART_Human0.89590782
139KDM5A_27292631_Chip-Seq_BREAST_Human0.88864911
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87131261
141SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86893178
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85760867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.55122730
2MP0001529_abnormal_vocalization3.37298362
3MP0002736_abnormal_nociception_after2.89828551
4MP0002009_preneoplasia2.89529054
5MP0001968_abnormal_touch/_nociception2.78807847
6MP0001188_hyperpigmentation2.60001258
7MP0001984_abnormal_olfaction2.48007370
8MP0003111_abnormal_nucleus_morphology2.45974355
9MP0008057_abnormal_DNA_replication2.45142838
10MP0003941_abnormal_skin_development2.40270251
11MP0006276_abnormal_autonomic_nervous2.38353294
12MP0009745_abnormal_behavioral_response2.35138678
13MP0005646_abnormal_pituitary_gland2.33712778
14MP0001905_abnormal_dopamine_level2.29309052
15MP0003635_abnormal_synaptic_transmissio2.28309916
16MP0002822_catalepsy2.23847156
17MP0002064_seizures2.22394411
18MP0009046_muscle_twitch2.21433115
19MP0002272_abnormal_nervous_system2.19894450
20MP0004859_abnormal_synaptic_plasticity2.15741969
21MP0001293_anophthalmia2.15554139
22MP0002572_abnormal_emotion/affect_behav2.11259154
23MP0002735_abnormal_chemical_nociception2.10093317
24MP0002734_abnormal_mechanical_nocicepti2.00075539
25MP0006292_abnormal_olfactory_placode1.99311916
26MP0008877_abnormal_DNA_methylation1.99134394
27MP0002063_abnormal_learning/memory/cond1.96930040
28MP0003787_abnormal_imprinting1.89744160
29MP0001486_abnormal_startle_reflex1.87449281
30MP0002837_dystrophic_cardiac_calcinosis1.86285935
31MP0002653_abnormal_ependyma_morphology1.86138576
32MP0004133_heterotaxia1.86012996
33MP0001440_abnormal_grooming_behavior1.85662149
34MP0004270_analgesia1.84905243
35MP0003718_maternal_effect1.78504246
36MP0003077_abnormal_cell_cycle1.76901778
37MP0009697_abnormal_copulation1.76075171
38MP0004142_abnormal_muscle_tone1.70984118
39MP0002067_abnormal_sensory_capabilities1.68428732
40MP0002638_abnormal_pupillary_reflex1.66921013
41MP0008007_abnormal_cellular_replicative1.66465099
42MP0002876_abnormal_thyroid_physiology1.64303152
43MP0001986_abnormal_taste_sensitivity1.63275659
44MP0002234_abnormal_pharynx_morphology1.58089292
45MP0003195_calcinosis1.57152075
46MP0008260_abnormal_autophagy1.55046383
47MP0003122_maternal_imprinting1.53445580
48MP0003136_yellow_coat_color1.53324033
49MP0000569_abnormal_digit_pigmentation1.53277397
50MP0003890_abnormal_embryonic-extraembry1.52383528
51MP0005171_absent_coat_pigmentation1.50633612
52MP0005645_abnormal_hypothalamus_physiol1.49289111
53MP0005423_abnormal_somatic_nervous1.49288104
54MP0003937_abnormal_limbs/digits/tail_de1.48212498
55MP0002163_abnormal_gland_morphology1.46466580
56MP0005386_behavior/neurological_phenoty1.45063008
57MP0004924_abnormal_behavior1.45063008
58MP0001970_abnormal_pain_threshold1.42338635
59MP0001501_abnormal_sleep_pattern1.39949581
60MP0008058_abnormal_DNA_repair1.39337501
61MP0003786_premature_aging1.38237963
62MP0006036_abnormal_mitochondrial_physio1.36940163
63MP0003567_abnormal_fetal_cardiomyocyte1.35420929
64MP0000778_abnormal_nervous_system1.35314788
65MP0006072_abnormal_retinal_apoptosis1.33839957
66MP0004043_abnormal_pH_regulation1.33425521
67MP0002557_abnormal_social/conspecific_i1.33115867
68MP0003123_paternal_imprinting1.31254123
69MP0006035_abnormal_mitochondrial_morpho1.29661804
70MP0002184_abnormal_innervation1.27973396
71MP0002233_abnormal_nose_morphology1.27121844
72MP0004215_abnormal_myocardial_fiber1.26814017
73MP0005253_abnormal_eye_physiology1.26355178
74MP0004147_increased_porphyrin_level1.23412559
75MP0002160_abnormal_reproductive_system1.19904074
76MP0003121_genomic_imprinting1.19230269
77MP0003646_muscle_fatigue1.17784133
78MP0003186_abnormal_redox_activity1.16284789
79MP0001929_abnormal_gametogenesis1.15672783
80MP0010386_abnormal_urinary_bladder1.15091147
81MP0002095_abnormal_skin_pigmentation1.13240268
82MP0002733_abnormal_thermal_nociception1.12861141
83MP0005551_abnormal_eye_electrophysiolog1.12484416
84MP0004742_abnormal_vestibular_system1.10279233
85MP0001963_abnormal_hearing_physiology1.09870425
86MP0002210_abnormal_sex_determination1.08556698
87MP0000647_abnormal_sebaceous_gland1.07532735
88MP0009379_abnormal_foot_pigmentation1.06103325
89MP0001299_abnormal_eye_distance/1.04451396
90MP0001145_abnormal_male_reproductive1.01147344
91MP0005394_taste/olfaction_phenotype1.00464350
92MP0005499_abnormal_olfactory_system1.00464350
93MP0008789_abnormal_olfactory_epithelium0.99432609
94MP0000653_abnormal_sex_gland0.99397215
95MP0003119_abnormal_digestive_system0.98832138
96MP0002102_abnormal_ear_morphology0.98750605
97MP0002066_abnormal_motor_capabilities/c0.98638013
98MP0003879_abnormal_hair_cell0.98628724
99MP0001485_abnormal_pinna_reflex0.97943659
100MP0005379_endocrine/exocrine_gland_phen0.97272847
101MP0005187_abnormal_penis_morphology0.97014984
102MP0008995_early_reproductive_senescence0.96918466
103MP0000372_irregular_coat_pigmentation0.96599054
104MP0000015_abnormal_ear_pigmentation0.96516999
105MP0001286_abnormal_eye_development0.96147592
106MP0002882_abnormal_neuron_morphology0.95745335
107MP0002938_white_spotting0.95407597
108MP0010094_abnormal_chromosome_stability0.95349342
109MP0002751_abnormal_autonomic_nervous0.94343449
110MP0000026_abnormal_inner_ear0.93396174
111MP0005409_darkened_coat_color0.91821749
112MP0008932_abnormal_embryonic_tissue0.91782629
113MP0003693_abnormal_embryo_hatching0.91567413
114MP0000427_abnormal_hair_cycle0.88398990
115MP0001730_embryonic_growth_arrest0.88179174
116MP0002752_abnormal_somatic_nervous0.87683459
117MP0002090_abnormal_vision0.87236223
118MP0001764_abnormal_homeostasis0.86675415
119MP0000631_abnormal_neuroendocrine_gland0.83789335
120MP0002127_abnormal_cardiovascular_syste0.83542117
121MP0005391_vision/eye_phenotype0.82972622
122MP0001119_abnormal_female_reproductive0.82220486
123MP0008872_abnormal_physiological_respon0.82184128
124MP0010030_abnormal_orbit_morphology0.81125343
125MP0002697_abnormal_eye_size0.81045218
126MP0004957_abnormal_blastocyst_morpholog0.80576000
127MP0004145_abnormal_muscle_electrophysio0.80317105
128MP0000955_abnormal_spinal_cord0.80306697
129MP0002254_reproductive_system_inflammat0.80275353
130MP0002084_abnormal_developmental_patter0.80037595
131MP0004811_abnormal_neuron_physiology0.79642337
132MP0003315_abnormal_perineum_morphology0.79165329
133MP0005332_abnormal_amino_acid0.78894345
134MP0002229_neurodegeneration0.77923326
135MP0003938_abnormal_ear_development0.77483716
136MP0002928_abnormal_bile_duct0.76566079
137MP0005380_embryogenesis_phenotype0.76393125
138MP0001672_abnormal_embryogenesis/_devel0.76393125
139MP0005084_abnormal_gallbladder_morpholo0.76173762
140MP0009672_abnormal_birth_weight0.75825140
141MP0004085_abnormal_heartbeat0.75773476
142MP0005174_abnormal_tail_pigmentation0.74872131
143MP0005410_abnormal_fertilization0.74377318
144MP0002085_abnormal_embryonic_tissue0.74267994
145MP0004197_abnormal_fetal_growth/weight/0.73758228
146MP0003698_abnormal_male_reproductive0.73484962
147MP0002132_abnormal_respiratory_system0.73286998
148MP0002152_abnormal_brain_morphology0.72052052
149MP0000749_muscle_degeneration0.71638207
150MP0001502_abnormal_circadian_rhythm0.71370640
151MP0008569_lethality_at_weaning0.71164509
152MP0003806_abnormal_nucleotide_metabolis0.71100756
153MP0000350_abnormal_cell_proliferation0.70553211

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.25128819
2Abnormal mitochondria in muscle tissue (HP:0008316)4.84461245
3Mitochondrial inheritance (HP:0001427)4.61848619
4Progressive macrocephaly (HP:0004481)4.44091913
5Acute encephalopathy (HP:0006846)4.19949570
6Increased CSF lactate (HP:0002490)4.14921930
7Focal motor seizures (HP:0011153)3.98558663
8Increased serum pyruvate (HP:0003542)3.91629919
9Abnormality of glycolysis (HP:0004366)3.91629919
10Hepatocellular necrosis (HP:0001404)3.86974569
11Increased hepatocellular lipid droplets (HP:0006565)3.54805487
12Hyperventilation (HP:0002883)3.50354080
133-Methylglutaconic aciduria (HP:0003535)3.47325070
14Abnormal hair whorl (HP:0010721)3.46171463
15Pancreatic islet-cell hyperplasia (HP:0004510)3.45289940
16Hypothermia (HP:0002045)3.31685877
17Febrile seizures (HP:0002373)3.26093699
18Hepatic necrosis (HP:0002605)3.21628063
19Atonic seizures (HP:0010819)3.17178082
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.11146385
21Abnormality of alanine metabolism (HP:0010916)3.11146385
22Hyperalaninemia (HP:0003348)3.11146385
23Medial flaring of the eyebrow (HP:0010747)3.10667588
24Renal Fanconi syndrome (HP:0001994)3.09403096
25Lipid accumulation in hepatocytes (HP:0006561)3.08922810
26Increased serum lactate (HP:0002151)3.07570874
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02695479
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.01729006
29Hyperglycinemia (HP:0002154)3.00883045
30Lactic acidosis (HP:0003128)2.98527440
31Optic disc pallor (HP:0000543)2.96260007
32Methylmalonic acidemia (HP:0002912)2.94462225
33Nephrogenic diabetes insipidus (HP:0009806)2.93726248
34Exercise intolerance (HP:0003546)2.93219344
35Microvesicular hepatic steatosis (HP:0001414)2.90905029
36Gait imbalance (HP:0002141)2.90701646
37Congenital primary aphakia (HP:0007707)2.87219567
38Epileptic encephalopathy (HP:0200134)2.86071902
39Abnormality of serum amino acid levels (HP:0003112)2.74792151
40Pancreatic fibrosis (HP:0100732)2.72226612
41Cerebral hypomyelination (HP:0006808)2.69439616
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66982549
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66982549
44Abnormal protein glycosylation (HP:0012346)2.64259069
45Abnormal glycosylation (HP:0012345)2.64259069
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.64259069
47Abnormal protein N-linked glycosylation (HP:0012347)2.64259069
48Respiratory failure (HP:0002878)2.62315837
49Leukodystrophy (HP:0002415)2.58917158
50Cerebral edema (HP:0002181)2.55700528
51Mutism (HP:0002300)2.54969297
52Neuroendocrine neoplasm (HP:0100634)2.51224325
53Colon cancer (HP:0003003)2.48864444
54Exercise-induced muscle cramps (HP:0003710)2.47937812
55Methylmalonic aciduria (HP:0012120)2.45639425
56Abnormal lung lobation (HP:0002101)2.43018912
57Pheochromocytoma (HP:0002666)2.40226718
58Birth length less than 3rd percentile (HP:0003561)2.37300182
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.34887410
60Absent/shortened dynein arms (HP:0200106)2.34887410
61Confusion (HP:0001289)2.34308498
62Increased intramyocellular lipid droplets (HP:0012240)2.32829949
63Poor coordination (HP:0002370)2.32233673
64True hermaphroditism (HP:0010459)2.29365248
65Homocystinuria (HP:0002156)2.29119725
66Abnormality of homocysteine metabolism (HP:0010919)2.29119725
67Meckel diverticulum (HP:0002245)2.28957236
68Neoplasm of the adrenal gland (HP:0100631)2.28807604
69Abnormality of renal resorption (HP:0011038)2.27712079
70Limb dystonia (HP:0002451)2.27130593
71Neoplasm of the peripheral nervous system (HP:0100007)2.26711073
72Reduced antithrombin III activity (HP:0001976)2.26394979
73Respiratory difficulties (HP:0002880)2.25554196
74Morphological abnormality of the pyramidal tract (HP:0002062)2.23259647
75Focal seizures (HP:0007359)2.22801413
76Abnormality of glycine metabolism (HP:0010895)2.20135592
77Abnormality of serine family amino acid metabolism (HP:0010894)2.20135592
78Abnormality of the ileum (HP:0001549)2.20034629
79Abnormal respiratory motile cilium morphology (HP:0005938)2.19790729
80Abnormal respiratory epithelium morphology (HP:0012253)2.19790729
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.19109019
82Hyperinsulinemic hypoglycemia (HP:0000825)2.18801348
83Abnormal ciliary motility (HP:0012262)2.18369564
84Abnormality of chromosome stability (HP:0003220)2.15782782
85Genital tract atresia (HP:0001827)2.12287608
86Dialeptic seizures (HP:0011146)2.11803675
87Abnormality of the pancreatic islet cells (HP:0006476)2.11345155
88Abnormality of endocrine pancreas physiology (HP:0012093)2.11345155
89Broad-based gait (HP:0002136)2.10615144
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.09718007
91Pendular nystagmus (HP:0012043)2.08751452
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.07610684
93Absence seizures (HP:0002121)2.05567711
94Vaginal atresia (HP:0000148)2.02001201
95Poor suck (HP:0002033)2.01986071
96Pancreatic cysts (HP:0001737)2.01553508
97Cutaneous melanoma (HP:0012056)2.00548705
98Palpitations (HP:0001962)1.99522173
99Abnormality of the labia minora (HP:0012880)1.97881933
100Fair hair (HP:0002286)1.97771395
101Hyperglycinuria (HP:0003108)1.96157251
102Unsteady gait (HP:0002317)1.95821562
103Abnormal respiratory motile cilium physiology (HP:0012261)1.93959959
104Exertional dyspnea (HP:0002875)1.93802160
105Inability to walk (HP:0002540)1.93652205
106Irregular epiphyses (HP:0010582)1.93137438
107Molar tooth sign on MRI (HP:0002419)1.92128161
108Abnormality of midbrain morphology (HP:0002418)1.92128161
109Multiple enchondromatosis (HP:0005701)1.91872064
110Hypoglycemic coma (HP:0001325)1.91271907
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.91259082
112Abnormality of the pons (HP:0007361)1.90457873
113Short tibia (HP:0005736)1.89632867
114CNS demyelination (HP:0007305)1.89286019
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88225197
116Nephronophthisis (HP:0000090)1.87210256
117Progressive cerebellar ataxia (HP:0002073)1.87147198
118Abnormal pupillary function (HP:0007686)1.86908517
119Hypoglycemic seizures (HP:0002173)1.85531960
120Myokymia (HP:0002411)1.84674310
121Lethargy (HP:0001254)1.83990640
122Increased muscle lipid content (HP:0009058)1.82981443
123Progressive external ophthalmoplegia (HP:0000590)1.81897688
124Congenital stationary night blindness (HP:0007642)1.81071631
125Protruding tongue (HP:0010808)1.79775310
126Aplasia/Hypoplasia of the lens (HP:0008063)1.79714980
127Progressive inability to walk (HP:0002505)1.79392672
128Hypoplasia of the pons (HP:0012110)1.79193731
129Abnormality of methionine metabolism (HP:0010901)1.78261904
130Fetal akinesia sequence (HP:0001989)1.77833170
131Emotional lability (HP:0000712)1.77171456
132Abnormality of the vitamin B12 metabolism (HP:0004341)1.76511433
133X-linked dominant inheritance (HP:0001423)1.76478175
134Absent eyebrow (HP:0002223)1.74201347
135Nephroblastoma (Wilms tumor) (HP:0002667)1.74180059
136CNS hypomyelination (HP:0003429)1.73770412
137Capillary hemangiomas (HP:0005306)1.73217989
138Bilateral microphthalmos (HP:0007633)1.72441569
139Abnormality of the preputium (HP:0100587)1.72134169
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71874554
141Type I transferrin isoform profile (HP:0003642)1.71794325
142Sloping forehead (HP:0000340)1.71585450
143Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71569627
144Chromsome breakage (HP:0040012)1.70709627
145Delusions (HP:0000746)1.70528689
146Dandy-Walker malformation (HP:0001305)1.70037017
147Type 2 muscle fiber atrophy (HP:0003554)1.69228011
148Polyphagia (HP:0002591)1.67465814
149Ependymoma (HP:0002888)1.67457263
150Specific learning disability (HP:0001328)1.66948792
151Bifid tongue (HP:0010297)1.65805982
152Type II lissencephaly (HP:0007260)1.64621705
153Abnormality of vitamin B metabolism (HP:0004340)1.64070431
154Abnormality of sulfur amino acid metabolism (HP:0004339)1.63983926
155Absent radius (HP:0003974)1.63666685
156Postnatal microcephaly (HP:0005484)1.63189950
157Esotropia (HP:0000565)1.63012073
158Broad foot (HP:0001769)1.55792060
159Generalized tonic-clonic seizures (HP:0002069)1.55487824
160Gaze-evoked nystagmus (HP:0000640)1.51181298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.85066505
2VRK24.46526279
3STK163.33954392
4TSSK62.89669179
5MAP4K22.72590998
6BUB12.70758692
7MAP3K122.64596316
8MAP2K72.52011522
9NME12.30705994
10TRIM282.29637110
11AKT32.19549764
12PNCK2.17538206
13NUAK12.16664895
14CDC71.94183058
15STK31.90957165
16VRK11.87051997
17EIF2AK11.80364927
18PLK21.80027276
19FRK1.67954042
20EPHA41.66417650
21CCNB11.65581567
22GRK71.61113213
23OXSR11.60189187
24NEK21.58903656
25TNIK1.54058218
26PDK21.51026798
27MKNK21.50461047
28NTRK31.50239465
29PRPF4B1.47031094
30MAP3K41.46911627
31BLK1.44320642
32PLK31.43950454
33SRPK11.39897981
34MAPK131.39391442
35TAF11.37787433
36BCR1.37287477
37MKNK11.33391430
38SIK31.31857867
39MST41.29223197
40BRD41.28929287
41ZAK1.28573361
42ADRBK21.27840848
43NEK61.25582334
44PLK41.24213182
45CDK191.23847136
46WEE11.22938390
47EIF2AK31.21038749
48BCKDK1.17995301
49BRAF1.16049818
50BMPR21.13867838
51PDK41.11410194
52PDK31.11410194
53DAPK11.09298836
54DYRK31.08741674
55STK38L1.07026417
56RPS6KA41.03265312
57ARAF1.02262998
58MYLK1.01650918
59ACVR1B1.00479183
60MINK11.00182547
61PINK10.98763363
62BMPR1B0.96974331
63NEK10.96923292
64PRKCG0.96791530
65CSNK1G10.96080375
66MARK10.95652896
67ATR0.95489773
68MUSK0.91917622
69CLK10.91581961
70SGK20.91342522
71YES10.89514856
72GRK50.87838084
73SGK4940.85703319
74SGK2230.85703319
75STK390.83403762
76CDK30.82465606
77CAMK2B0.81938544
78CSNK1G20.81072323
79BRSK20.77867150
80CDK80.76853130
81DYRK20.74368799
82PAK30.73642138
83BRSK10.72899966
84DAPK20.72100450
85CAMK2A0.70750318
86PRKCE0.70443804
87MAP2K40.68467836
88ATM0.67682364
89PHKG20.66431175
90PHKG10.66431175
91EIF2AK20.64395718
92AURKA0.63941839
93CSNK1A1L0.61282617
94STK240.60936075
95FLT30.60902380
96OBSCN0.59447311
97DYRK1A0.59276286
98PIM20.58033338
99RPS6KA50.57982585
100WNK30.57351859
101MAPKAPK50.56114523
102CSNK1G30.55388966
103CHEK10.54013094
104TXK0.51281454
105PLK10.50766654
106ADRBK10.49166989
107CAMK2D0.48876850
108CSNK1A10.48433797
109CDK70.47987584
110PASK0.47924814
111ALK0.47765156
112TAOK30.45636678
113DYRK1B0.43929936
114CAMK2G0.43841701
115NTRK20.43688738
116WNK40.42465767
117IRAK40.41548325
118PRKCI0.40980295
119ERBB40.40933384
120CSNK2A10.40924028
121FGFR20.40818798
122ERBB30.40660863
123MAPK70.39948052
124TLK10.39871728
125PRKACA0.38305155
126CAMK40.37360105
127TIE10.37134917
128CDK180.36953973
129PBK0.36218838
130CSNK2A20.36188230
131CHEK20.35753864
132CAMKK20.35496592
133TTK0.34890448
134EGFR0.34658068
135CDK10.34046298
136AURKB0.33692427
137CDK50.32660357
138GRK10.32453259
139FES0.32369255
140TEC0.32363138
141IRAK10.32206182
142CSNK1E0.30071334
143PIM10.30009045
144CSNK1D0.27227796

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.40679315
2Proteasome_Homo sapiens_hsa030503.85589168
3Parkinsons disease_Homo sapiens_hsa050123.67816981
4RNA polymerase_Homo sapiens_hsa030203.40020800
5Huntingtons disease_Homo sapiens_hsa050162.91667839
6Nicotine addiction_Homo sapiens_hsa050332.89637152
7Alzheimers disease_Homo sapiens_hsa050102.72435914
8Collecting duct acid secretion_Homo sapiens_hsa049662.42999734
9Protein export_Homo sapiens_hsa030602.13713594
10One carbon pool by folate_Homo sapiens_hsa006701.98709261
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98270659
12Synaptic vesicle cycle_Homo sapiens_hsa047211.95330727
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90058400
14Vitamin B6 metabolism_Homo sapiens_hsa007501.83564089
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83124572
16Basal transcription factors_Homo sapiens_hsa030221.75384848
17Pyrimidine metabolism_Homo sapiens_hsa002401.72097191
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71724440
19Cardiac muscle contraction_Homo sapiens_hsa042601.70228217
20Ribosome_Homo sapiens_hsa030101.67076356
21Vitamin digestion and absorption_Homo sapiens_hsa049771.63712839
22Homologous recombination_Homo sapiens_hsa034401.63129343
23Mismatch repair_Homo sapiens_hsa034301.61368225
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58262248
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57244902
26Selenocompound metabolism_Homo sapiens_hsa004501.56385897
27Vibrio cholerae infection_Homo sapiens_hsa051101.51074389
28Taste transduction_Homo sapiens_hsa047421.46268990
29Purine metabolism_Homo sapiens_hsa002301.46098950
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40721937
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40036956
32Nucleotide excision repair_Homo sapiens_hsa034201.39563599
33Amphetamine addiction_Homo sapiens_hsa050311.35142816
34Olfactory transduction_Homo sapiens_hsa047401.34388978
35Morphine addiction_Homo sapiens_hsa050321.32452224
36GABAergic synapse_Homo sapiens_hsa047271.32128483
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32084772
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32034250
39Spliceosome_Homo sapiens_hsa030401.30975421
40Fatty acid elongation_Homo sapiens_hsa000621.30309864
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27095433
42Serotonergic synapse_Homo sapiens_hsa047261.26652062
43DNA replication_Homo sapiens_hsa030301.25877762
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22484111
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21747037
46Fanconi anemia pathway_Homo sapiens_hsa034601.21606552
47Phototransduction_Homo sapiens_hsa047441.19835132
48RNA transport_Homo sapiens_hsa030131.18966585
49Regulation of autophagy_Homo sapiens_hsa041401.16220733
50Sulfur relay system_Homo sapiens_hsa041221.10375943
51Circadian entrainment_Homo sapiens_hsa047131.05419377
52Glutamatergic synapse_Homo sapiens_hsa047241.02746981
53Base excision repair_Homo sapiens_hsa034101.00949386
54Peroxisome_Homo sapiens_hsa041460.97232388
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95953308
56Pyruvate metabolism_Homo sapiens_hsa006200.95481252
57RNA degradation_Homo sapiens_hsa030180.95132153
58Dopaminergic synapse_Homo sapiens_hsa047280.93150075
59Folate biosynthesis_Homo sapiens_hsa007900.91590270
60p53 signaling pathway_Homo sapiens_hsa041150.84841005
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.82158318
62Long-term potentiation_Homo sapiens_hsa047200.81819880
63Biosynthesis of amino acids_Homo sapiens_hsa012300.77911612
64Metabolic pathways_Homo sapiens_hsa011000.76065676
65Calcium signaling pathway_Homo sapiens_hsa040200.76019259
66Non-homologous end-joining_Homo sapiens_hsa034500.74810687
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73616333
68Rheumatoid arthritis_Homo sapiens_hsa053230.69767093
69Ether lipid metabolism_Homo sapiens_hsa005650.69761630
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67538299
71Oocyte meiosis_Homo sapiens_hsa041140.67016854
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.66766363
73Tryptophan metabolism_Homo sapiens_hsa003800.66047926
74Nitrogen metabolism_Homo sapiens_hsa009100.61962817
75Long-term depression_Homo sapiens_hsa047300.61468091
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61185282
77Cell cycle_Homo sapiens_hsa041100.59038256
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58624058
79Cocaine addiction_Homo sapiens_hsa050300.58534951
80Arachidonic acid metabolism_Homo sapiens_hsa005900.57903999
81Insulin secretion_Homo sapiens_hsa049110.52789249
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52591629
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52115011
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51689052
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47983348
86Salivary secretion_Homo sapiens_hsa049700.47739652
87Propanoate metabolism_Homo sapiens_hsa006400.47718551
88Fatty acid metabolism_Homo sapiens_hsa012120.46280302
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45820894
90Carbon metabolism_Homo sapiens_hsa012000.44647293
91Sphingolipid metabolism_Homo sapiens_hsa006000.44619329
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.44444834
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44167612
94Phagosome_Homo sapiens_hsa041450.44094599
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42992777
96Linoleic acid metabolism_Homo sapiens_hsa005910.42916576
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40850718
98Epstein-Barr virus infection_Homo sapiens_hsa051690.39989589
99N-Glycan biosynthesis_Homo sapiens_hsa005100.39885205
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38934416
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38932720
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38539740
103Butanoate metabolism_Homo sapiens_hsa006500.38076858
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37800271
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37683900
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36680558
107Fatty acid degradation_Homo sapiens_hsa000710.36329361
108Cholinergic synapse_Homo sapiens_hsa047250.36110195
109Tyrosine metabolism_Homo sapiens_hsa003500.35862393
110Retinol metabolism_Homo sapiens_hsa008300.35658745
111Fructose and mannose metabolism_Homo sapiens_hsa000510.35534584
112Renin secretion_Homo sapiens_hsa049240.34574581
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.32500816
114Lysine degradation_Homo sapiens_hsa003100.30941929
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30628921
116mRNA surveillance pathway_Homo sapiens_hsa030150.29127318
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28519492
118beta-Alanine metabolism_Homo sapiens_hsa004100.27037854
119Sulfur metabolism_Homo sapiens_hsa009200.26450206
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26054935
121Alcoholism_Homo sapiens_hsa050340.25470670
122Glutathione metabolism_Homo sapiens_hsa004800.24158542
123Steroid biosynthesis_Homo sapiens_hsa001000.22491430
124Arginine and proline metabolism_Homo sapiens_hsa003300.22165897
125Circadian rhythm_Homo sapiens_hsa047100.21418372
126Oxytocin signaling pathway_Homo sapiens_hsa049210.21264327
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.20775595
128Chemical carcinogenesis_Homo sapiens_hsa052040.19308926
129Phenylalanine metabolism_Homo sapiens_hsa003600.19245775
130TGF-beta signaling pathway_Homo sapiens_hsa043500.18965514
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18158740
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17400006
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17146862
134Caffeine metabolism_Homo sapiens_hsa002320.16494839
135Type I diabetes mellitus_Homo sapiens_hsa049400.16293692
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14017295

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