

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 9.42771770 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 8.85080938 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 8.85080938 |
| 4 | * mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 8.60020342 |
| 5 | * respiratory electron transport chain (GO:0022904) | 8.00933723 |
| 6 | * electron transport chain (GO:0022900) | 7.81330793 |
| 7 | ribosomal small subunit biogenesis (GO:0042274) | 7.02222752 |
| 8 | tricarboxylic acid cycle (GO:0006099) | 5.97032553 |
| 9 | maturation of SSU-rRNA (GO:0030490) | 5.80841794 |
| 10 | oxidative phosphorylation (GO:0006119) | 5.58804402 |
| 11 | viral transcription (GO:0019083) | 5.51038357 |
| 12 | ATP biosynthetic process (GO:0006754) | 5.29068627 |
| 13 | translational termination (GO:0006415) | 5.23210293 |
| 14 | ribosomal small subunit assembly (GO:0000028) | 4.97728176 |
| 15 | NADH metabolic process (GO:0006734) | 4.92948586 |
| 16 | translational elongation (GO:0006414) | 4.72016675 |
| 17 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 4.69162883 |
| 18 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.65484428 |
| 19 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.64757926 |
| 20 | hydrogen ion transmembrane transport (GO:1902600) | 4.59899908 |
| 21 | inner mitochondrial membrane organization (GO:0007007) | 4.55738943 |
| 22 | cotranslational protein targeting to membrane (GO:0006613) | 4.55220416 |
| 23 | protein targeting to ER (GO:0045047) | 4.53133473 |
| 24 | sarcomere organization (GO:0045214) | 4.51912378 |
| 25 | protein complex biogenesis (GO:0070271) | 4.41219867 |
| 26 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.38458191 |
| 27 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.34349939 |
| 28 | protein localization to endoplasmic reticulum (GO:0070972) | 4.32859235 |
| 29 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 4.30208019 |
| 30 | succinate metabolic process (GO:0006105) | 4.25925134 |
| 31 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.24765656 |
| 32 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.24765656 |
| 33 | NADH dehydrogenase complex assembly (GO:0010257) | 4.24765656 |
| 34 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 4.23963769 |
| 35 | rRNA modification (GO:0000154) | 4.22338323 |
| 36 | viral life cycle (GO:0019058) | 4.22104440 |
| 37 | pseudouridine synthesis (GO:0001522) | 4.19110134 |
| 38 | chaperone-mediated protein transport (GO:0072321) | 4.12061770 |
| 39 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.10279898 |
| 40 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.09126206 |
| 41 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 4.09063404 |
| 42 | translation (GO:0006412) | 4.08887114 |
| 43 | cellular protein complex disassembly (GO:0043624) | 4.06723008 |
| 44 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.06053896 |
| 45 | ribosomal large subunit biogenesis (GO:0042273) | 4.05859487 |
| 46 | proteasome assembly (GO:0043248) | 4.04593401 |
| 47 | proton transport (GO:0015992) | 4.03925889 |
| 48 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.02479661 |
| 49 | translational initiation (GO:0006413) | 4.02308472 |
| 50 | respiratory chain complex IV assembly (GO:0008535) | 4.00897608 |
| 51 | hydrogen transport (GO:0006818) | 3.99209860 |
| 52 | regulation of coenzyme metabolic process (GO:0051196) | 3.99084239 |
| 53 | regulation of cofactor metabolic process (GO:0051193) | 3.99084239 |
| 54 | establishment of protein localization to mitochondrion (GO:0072655) | 3.98855252 |
| 55 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.97805618 |
| 56 | GDP-mannose metabolic process (GO:0019673) | 3.94346534 |
| 57 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.94241042 |
| 58 | aerobic respiration (GO:0009060) | 3.91457795 |
| 59 | cellular component biogenesis (GO:0044085) | 3.90206373 |
| 60 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 3.87897704 |
| 61 | cytochrome complex assembly (GO:0017004) | 3.82932249 |
| 62 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.82831235 |
| 63 | protein localization to mitochondrion (GO:0070585) | 3.79870439 |
| 64 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.76876568 |
| 65 | termination of RNA polymerase III transcription (GO:0006386) | 3.76876568 |
| 66 | cardiac myofibril assembly (GO:0055003) | 3.75664642 |
| 67 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.75384366 |
| 68 | ubiquinone biosynthetic process (GO:0006744) | 3.74238747 |
| 69 | quinone biosynthetic process (GO:1901663) | 3.74238747 |
| 70 | metallo-sulfur cluster assembly (GO:0031163) | 3.74129002 |
| 71 | iron-sulfur cluster assembly (GO:0016226) | 3.74129002 |
| 72 | actin-myosin filament sliding (GO:0033275) | 3.72592936 |
| 73 | muscle filament sliding (GO:0030049) | 3.72592936 |
| 74 | regulation of oxidative phosphorylation (GO:0002082) | 3.70259832 |
| 75 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.69810276 |
| 76 | regulation of cell communication by electrical coupling (GO:0010649) | 3.63482142 |
| 77 | regulation of mitochondrial translation (GO:0070129) | 3.60954002 |
| 78 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.59005799 |
| 79 | oxaloacetate metabolic process (GO:0006107) | 3.58207370 |
| 80 | myofibril assembly (GO:0030239) | 3.56184605 |
| 81 | protein complex disassembly (GO:0043241) | 3.55440865 |
| 82 | cardiac muscle contraction (GO:0060048) | 3.53665069 |
| 83 | regulation of relaxation of muscle (GO:1901077) | 3.53629551 |
| 84 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.51252370 |
| 85 | heart contraction (GO:0060047) | 3.49851231 |
| 86 | heart process (GO:0003015) | 3.49851231 |
| 87 | cullin deneddylation (GO:0010388) | 3.47362163 |
| 88 | base-excision repair, AP site formation (GO:0006285) | 3.45383155 |
| 89 | regulation of actin filament-based movement (GO:1903115) | 3.43799044 |
| 90 | negative regulation of ligase activity (GO:0051352) | 3.43171879 |
| 91 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.43171879 |
| 92 | rRNA processing (GO:0006364) | 3.41946722 |
| 93 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.40846878 |
| 94 | macromolecular complex disassembly (GO:0032984) | 3.40095535 |
| 95 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.35723440 |
| 96 | peptidyl-histidine modification (GO:0018202) | 3.34287712 |
| 97 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.34107478 |
| 98 | * generation of precursor metabolites and energy (GO:0006091) | 3.34081407 |
| 99 | protein deneddylation (GO:0000338) | 3.32004173 |
| 100 | ubiquinone metabolic process (GO:0006743) | 3.31989099 |
| 101 | rRNA methylation (GO:0031167) | 3.28067779 |
| 102 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.27328504 |
| 103 | rRNA metabolic process (GO:0016072) | 3.24775528 |
| 104 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.24443715 |
| 105 | mitochondrial transport (GO:0006839) | 3.24023947 |
| 106 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.23720785 |
| 107 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.23720785 |
| 108 | cellular ketone body metabolic process (GO:0046950) | 3.23490673 |
| 109 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.23065617 |
| 110 | GTP biosynthetic process (GO:0006183) | 3.21654559 |
| 111 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 3.18671428 |
| 112 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 3.18178384 |
| 113 | cellular respiration (GO:0045333) | 3.16730160 |
| 114 | deoxyribonucleotide catabolic process (GO:0009264) | 3.16494278 |
| 115 | regulation of cellular respiration (GO:0043457) | 3.15436417 |
| 116 | protein targeting to membrane (GO:0006612) | 3.15187298 |
| 117 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.14754018 |
| 118 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.14754018 |
| 119 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.14587023 |
| 120 | aspartate family amino acid catabolic process (GO:0009068) | 3.14361694 |
| 121 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.14205973 |
| 122 | protein neddylation (GO:0045116) | 3.12425627 |
| 123 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.11389114 |
| 124 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.09003363 |
| 125 | regulation of sulfur metabolic process (GO:0042762) | 3.08527120 |
| 126 | formation of translation preinitiation complex (GO:0001731) | 3.05534539 |
| 127 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.02366664 |
| 128 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.00958968 |
| 129 | DNA replication checkpoint (GO:0000076) | 2.99993381 |
| 130 | deoxyribose phosphate catabolic process (GO:0046386) | 2.98123132 |
| 131 | branched-chain amino acid catabolic process (GO:0009083) | 2.97749316 |
| 132 | actin-mediated cell contraction (GO:0070252) | 2.97164079 |
| 133 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.97078930 |
| 134 | UTP biosynthetic process (GO:0006228) | 2.96920505 |
| 135 | nucleoside monophosphate biosynthetic process (GO:0009124) | 2.96565289 |
| 136 | regulation of skeletal muscle contraction (GO:0014819) | 2.96375851 |
| 137 | 2-oxoglutarate metabolic process (GO:0006103) | 2.95745362 |
| 138 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.95712772 |
| 139 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.94004257 |
| 140 | cardiac muscle tissue morphogenesis (GO:0055008) | 2.93281181 |
| 141 | fatty acid beta-oxidation (GO:0006635) | 2.92774595 |
| 142 | adult heart development (GO:0007512) | 2.91986806 |
| 143 | regulation of sequestering of triglyceride (GO:0010889) | 2.90163568 |
| 144 | regulation of striated muscle contraction (GO:0006942) | 2.88392664 |
| 145 | cardiac muscle cell development (GO:0055013) | 2.85530160 |
| 146 | striated muscle contraction (GO:0006941) | 2.85043216 |
| 147 | ketone body metabolic process (GO:1902224) | 2.82303181 |
| 148 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 2.81799518 |
| 149 | regulation of membrane repolarization (GO:0060306) | 2.81093879 |
| 150 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.80891772 |
| 151 | negative regulation of protein localization to cell surface (GO:2000009) | 2.79935290 |
| 152 | creatine metabolic process (GO:0006600) | 2.79535732 |
| 153 | fatty acid catabolic process (GO:0009062) | 2.76693166 |
| 154 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 2.76575945 |
| 155 | purine ribonucleoside biosynthetic process (GO:0046129) | 2.76312075 |
| 156 | purine nucleoside biosynthetic process (GO:0042451) | 2.76312075 |
| 157 | carnitine shuttle (GO:0006853) | 2.75778435 |
| 158 | short-chain fatty acid metabolic process (GO:0046459) | 2.74949905 |
| 159 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 2.73480470 |
| 160 | lysine catabolic process (GO:0006554) | 2.73313436 |
| 161 | lysine metabolic process (GO:0006553) | 2.73313436 |
| 162 | dopamine transport (GO:0015872) | 2.70606790 |
| 163 | detection of calcium ion (GO:0005513) | 2.67634387 |
| 164 | protein targeting to mitochondrion (GO:0006626) | 2.63084238 |
| 165 | muscle tissue morphogenesis (GO:0060415) | 2.62896489 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.91630261 |
| 2 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.38409743 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.64821830 |
| 4 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.13463250 |
| 5 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.00566739 |
| 6 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.98511286 |
| 7 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.87556337 |
| 8 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.86229533 |
| 9 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.68049288 |
| 10 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.65307966 |
| 11 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.64845145 |
| 12 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.49755402 |
| 13 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.39681350 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.32939856 |
| 15 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.27921399 |
| 16 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.19551962 |
| 17 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.18789239 |
| 18 | * TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.18703274 |
| 19 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.17668634 |
| 20 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.13677250 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 2.08617611 |
| 22 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.03348293 |
| 23 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.02691192 |
| 24 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.02258688 |
| 25 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.99398488 |
| 26 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.97048784 |
| 27 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.96743787 |
| 28 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.92171869 |
| 29 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.86460005 |
| 30 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.83011275 |
| 31 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.80800806 |
| 32 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.79441338 |
| 33 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.78771421 |
| 34 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.74886588 |
| 35 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.74633705 |
| 36 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.72521179 |
| 37 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.72449973 |
| 38 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.72129619 |
| 39 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.71972897 |
| 40 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.71166186 |
| 41 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.66330888 |
| 42 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.63838982 |
| 43 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.62859182 |
| 44 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.61473377 |
| 45 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.60713466 |
| 46 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.59319539 |
| 47 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.53357074 |
| 48 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.50239379 |
| 49 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.49429017 |
| 50 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.49248917 |
| 51 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49192714 |
| 52 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.44429361 |
| 53 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.43377275 |
| 54 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.43308882 |
| 55 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.42655867 |
| 56 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.40755865 |
| 57 | P68_20966046_ChIP-Seq_HELA_Human | 1.38797681 |
| 58 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.38597056 |
| 59 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.34974933 |
| 60 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.33339714 |
| 61 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.32441529 |
| 62 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.32211033 |
| 63 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.31285959 |
| 64 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30129881 |
| 65 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.29646563 |
| 66 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.28887604 |
| 67 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28877079 |
| 68 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.26280722 |
| 69 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.26132150 |
| 70 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.25658365 |
| 71 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.25199482 |
| 72 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.22359282 |
| 73 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.21678361 |
| 74 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.21529134 |
| 75 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.20691357 |
| 76 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.18700419 |
| 77 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.17527689 |
| 78 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.17274644 |
| 79 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.17184103 |
| 80 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.16965919 |
| 81 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.16677827 |
| 82 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.16194717 |
| 83 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.15767922 |
| 84 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.15270254 |
| 85 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.15241984 |
| 86 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.14324195 |
| 87 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.14243021 |
| 88 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.13827762 |
| 89 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.13176314 |
| 90 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.13049161 |
| 91 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.12274972 |
| 92 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.11670187 |
| 93 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.11231298 |
| 94 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10961687 |
| 95 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.09770141 |
| 96 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.09736137 |
| 97 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.07913554 |
| 98 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.07846687 |
| 99 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.07819505 |
| 100 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.07814527 |
| 101 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.07324415 |
| 102 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.07251466 |
| 103 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.06714730 |
| 104 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.06115277 |
| 105 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06076531 |
| 106 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.05792484 |
| 107 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.05504422 |
| 108 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.05504422 |
| 109 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.05357189 |
| 110 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.05149329 |
| 111 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.04951608 |
| 112 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.04851329 |
| 113 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.04542533 |
| 114 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.03817454 |
| 115 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.03662605 |
| 116 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.03206829 |
| 117 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.03116284 |
| 118 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.02626673 |
| 119 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.02442353 |
| 120 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.02298829 |
| 121 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.02005720 |
| 122 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.01573144 |
| 123 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.01331723 |
| 124 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.01238658 |
| 125 | SA1_27219007_Chip-Seq_Bcells_Human | 1.01086284 |
| 126 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.00351928 |
| 127 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.98997356 |
| 128 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.98824966 |
| 129 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.98786650 |
| 130 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.98119195 |
| 131 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.97185644 |
| 132 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.97094633 |
| 133 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.96812300 |
| 134 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 0.96716851 |
| 135 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.95754649 |
| 136 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.95264427 |
| 137 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.95109694 |
| 138 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.94706724 |
| 139 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.94680366 |
| 140 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.94265683 |
| 141 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.94038273 |
| 142 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.93407233 |
| 143 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 0.93057265 |
| 144 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.93037878 |
| 145 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.92575661 |
| 146 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.91338426 |
| 147 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.91099841 |
| 148 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.90919223 |
| 149 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.90308932 |
| 150 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.89540102 |
| 151 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.87883283 |
| 152 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.87700936 |
| 153 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.87270503 |
| 154 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.87270503 |
| 155 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.86985290 |
| 156 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.86901800 |
| 157 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.84856806 |
| 158 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.84334218 |
| 159 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.84113227 |
| 160 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.83507541 |
| 161 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.81936703 |
| 162 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.81936019 |
| 163 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.80719743 |
| 164 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.80673890 |
| 165 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.80029323 |
| 166 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.79782479 |
| 167 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.78900710 |
| 168 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.78505666 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 6.02765678 |
| 2 | MP0003646_muscle_fatigue | 4.80434708 |
| 3 | MP0000751_myopathy | 4.11554969 |
| 4 | MP0004215_abnormal_myocardial_fiber | 3.61123578 |
| 5 | MP0004084_abnormal_cardiac_muscle | 3.59333563 |
| 6 | MP0004036_abnormal_muscle_relaxation | 3.26246869 |
| 7 | MP0000749_muscle_degeneration | 3.17578214 |
| 8 | MP0006036_abnormal_mitochondrial_physio | 3.00055546 |
| 9 | MP0005330_cardiomyopathy | 2.89379047 |
| 10 | MP0003693_abnormal_embryo_hatching | 2.59289484 |
| 11 | MP0001529_abnormal_vocalization | 2.54550507 |
| 12 | MP0001188_hyperpigmentation | 2.46804053 |
| 13 | MP0003880_abnormal_central_pattern | 2.43187989 |
| 14 | MP0002822_catalepsy | 2.36358481 |
| 15 | MP0003137_abnormal_impulse_conducting | 2.32885146 |
| 16 | MP0002972_abnormal_cardiac_muscle | 2.23804238 |
| 17 | MP0005423_abnormal_somatic_nervous | 2.23777936 |
| 18 | MP0006035_abnormal_mitochondrial_morpho | 2.13795480 |
| 19 | MP0004957_abnormal_blastocyst_morpholog | 2.10490563 |
| 20 | MP0004484_altered_response_of | 2.07042948 |
| 21 | MP0006292_abnormal_olfactory_placode | 2.03060904 |
| 22 | MP0005620_abnormal_muscle_contractility | 1.98575828 |
| 23 | MP0008058_abnormal_DNA_repair | 1.97644579 |
| 24 | MP0001986_abnormal_taste_sensitivity | 1.96563615 |
| 25 | MP0004145_abnormal_muscle_electrophysio | 1.95157966 |
| 26 | MP0004130_abnormal_muscle_cell | 1.91318717 |
| 27 | MP0008775_abnormal_heart_ventricle | 1.87316936 |
| 28 | MP0003111_abnormal_nucleus_morphology | 1.85529237 |
| 29 | MP0004087_abnormal_muscle_fiber | 1.82640393 |
| 30 | MP0003786_premature_aging | 1.82257457 |
| 31 | MP0008932_abnormal_embryonic_tissue | 1.79734861 |
| 32 | MP0004085_abnormal_heartbeat | 1.73635612 |
| 33 | MP0001544_abnormal_cardiovascular_syste | 1.72666115 |
| 34 | MP0005385_cardiovascular_system_phenoty | 1.72666115 |
| 35 | MP0002106_abnormal_muscle_physiology | 1.72224974 |
| 36 | MP0003806_abnormal_nucleotide_metabolis | 1.71121903 |
| 37 | MP0001905_abnormal_dopamine_level | 1.70555166 |
| 38 | MP0000750_abnormal_muscle_regeneration | 1.69586898 |
| 39 | MP0002332_abnormal_exercise_endurance | 1.67586931 |
| 40 | MP0006276_abnormal_autonomic_nervous | 1.65107613 |
| 41 | MP0004043_abnormal_pH_regulation | 1.64969744 |
| 42 | MP0000747_muscle_weakness | 1.64894006 |
| 43 | MP0006138_congestive_heart_failure | 1.61003840 |
| 44 | MP0002160_abnormal_reproductive_system | 1.60711054 |
| 45 | MP0003123_paternal_imprinting | 1.59872744 |
| 46 | MP0008789_abnormal_olfactory_epithelium | 1.59790512 |
| 47 | MP0010094_abnormal_chromosome_stability | 1.57091088 |
| 48 | MP0010030_abnormal_orbit_morphology | 1.54558908 |
| 49 | MP0005171_absent_coat_pigmentation | 1.54408362 |
| 50 | MP0002269_muscular_atrophy | 1.52860275 |
| 51 | MP0003195_calcinosis | 1.47169588 |
| 52 | MP0004142_abnormal_muscle_tone | 1.46727858 |
| 53 | MP0003077_abnormal_cell_cycle | 1.43332199 |
| 54 | MP0005369_muscle_phenotype | 1.41528806 |
| 55 | MP0001661_extended_life_span | 1.40789030 |
| 56 | MP0002163_abnormal_gland_morphology | 1.39358169 |
| 57 | MP0005085_abnormal_gallbladder_physiolo | 1.38907774 |
| 58 | MP0009046_muscle_twitch | 1.37153397 |
| 59 | MP0003011_delayed_dark_adaptation | 1.36025370 |
| 60 | MP0002272_abnormal_nervous_system | 1.35536549 |
| 61 | MP0000759_abnormal_skeletal_muscle | 1.34625385 |
| 62 | MP0009745_abnormal_behavioral_response | 1.33842412 |
| 63 | MP0008875_abnormal_xenobiotic_pharmacok | 1.33402589 |
| 64 | MP0000372_irregular_coat_pigmentation | 1.32758706 |
| 65 | MP0002064_seizures | 1.30977439 |
| 66 | MP0002736_abnormal_nociception_after | 1.29339093 |
| 67 | MP0003221_abnormal_cardiomyocyte_apopto | 1.25745042 |
| 68 | MP0002139_abnormal_hepatobiliary_system | 1.25103215 |
| 69 | MP0001440_abnormal_grooming_behavior | 1.24178020 |
| 70 | MP0005332_abnormal_amino_acid | 1.23870915 |
| 71 | MP0004924_abnormal_behavior | 1.23029489 |
| 72 | MP0005386_behavior/neurological_phenoty | 1.23029489 |
| 73 | MP0008995_early_reproductive_senescence | 1.21042514 |
| 74 | MP0005670_abnormal_white_adipose | 1.20110969 |
| 75 | MP0005535_abnormal_body_temperature | 1.19252429 |
| 76 | MP0009379_abnormal_foot_pigmentation | 1.18792179 |
| 77 | MP0004147_increased_porphyrin_level | 1.18627926 |
| 78 | MP0001968_abnormal_touch/_nociception | 1.16055875 |
| 79 | MP0005266_abnormal_metabolism | 1.12834009 |
| 80 | MP0001764_abnormal_homeostasis | 1.12530771 |
| 81 | MP0010630_abnormal_cardiac_muscle | 1.11916123 |
| 82 | MP0003635_abnormal_synaptic_transmissio | 1.11152867 |
| 83 | MP0000678_abnormal_parathyroid_gland | 1.10270874 |
| 84 | MP0005083_abnormal_biliary_tract | 1.07463219 |
| 85 | MP0000230_abnormal_systemic_arterial | 1.07261728 |
| 86 | MP0005360_urolithiasis | 1.06252682 |
| 87 | MP0003950_abnormal_plasma_membrane | 1.05698926 |
| 88 | MP0005174_abnormal_tail_pigmentation | 1.05390784 |
| 89 | MP0002127_abnormal_cardiovascular_syste | 1.03724613 |
| 90 | MP0002735_abnormal_chemical_nociception | 1.00747773 |
| 91 | MP0000049_abnormal_middle_ear | 1.00732281 |
| 92 | MP0005394_taste/olfaction_phenotype | 1.00376663 |
| 93 | MP0005499_abnormal_olfactory_system | 1.00376663 |
| 94 | MP0003718_maternal_effect | 0.99347510 |
| 95 | MP0005451_abnormal_body_composition | 0.98446954 |
| 96 | MP0005165_increased_susceptibility_to | 0.96559112 |
| 97 | MP0000013_abnormal_adipose_tissue | 0.96376910 |
| 98 | MP0008007_abnormal_cellular_replicative | 0.95695943 |
| 99 | MP0003315_abnormal_perineum_morphology | 0.95114485 |
| 100 | MP0000358_abnormal_cell_content/ | 0.94609406 |
| 101 | MP0002572_abnormal_emotion/affect_behav | 0.93806355 |
| 102 | MP0002876_abnormal_thyroid_physiology | 0.92896555 |
| 103 | MP0004270_analgesia | 0.90527253 |
| 104 | MP0005666_abnormal_adipose_tissue | 0.88851549 |
| 105 | MP0001501_abnormal_sleep_pattern | 0.88809026 |
| 106 | MP0001970_abnormal_pain_threshold | 0.88510833 |
| 107 | MP0004233_abnormal_muscle_weight | 0.87933045 |
| 108 | MP0005646_abnormal_pituitary_gland | 0.87911830 |
| 109 | MP0002909_abnormal_adrenal_gland | 0.87419972 |
| 110 | MP0002067_abnormal_sensory_capabilities | 0.87217297 |
| 111 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.86914839 |
| 112 | MP0003186_abnormal_redox_activity | 0.86534022 |
| 113 | MP0002734_abnormal_mechanical_nocicepti | 0.86425079 |
| 114 | MP0002234_abnormal_pharynx_morphology | 0.86163800 |
| 115 | MP0002938_white_spotting | 0.85186223 |
| 116 | MP0005084_abnormal_gallbladder_morpholo | 0.84134694 |
| 117 | MP0003828_pulmonary_edema | 0.81875042 |
| 118 | MP0002063_abnormal_learning/memory/cond | 0.80535704 |
| 119 | MP0008872_abnormal_physiological_respon | 0.80446833 |
| 120 | MP0001486_abnormal_startle_reflex | 0.78953854 |
| 121 | MP0005389_reproductive_system_phenotype | 0.78855476 |
| 122 | MP0003136_yellow_coat_color | 0.78852715 |
| 123 | MP0002249_abnormal_larynx_morphology | 0.77900776 |
| 124 | MP0001727_abnormal_embryo_implantation | 0.77748367 |
| 125 | MP0003329_amyloid_beta_deposits | 0.76054770 |
| 126 | MP0002277_abnormal_respiratory_mucosa | 0.75859974 |
| 127 | MP0004858_abnormal_nervous_system | 0.75408532 |
| 128 | MP0000538_abnormal_urinary_bladder | 0.74205216 |
| 129 | MP0005636_abnormal_mineral_homeostasis | 0.74200024 |
| 130 | MP0002733_abnormal_thermal_nociception | 0.73591191 |
| 131 | MP0001984_abnormal_olfaction | 0.71304379 |
| 132 | MP0004859_abnormal_synaptic_plasticity | 0.70754217 |
| 133 | MP0001756_abnormal_urination | 0.68960336 |
| 134 | MP0003656_abnormal_erythrocyte_physiolo | 0.68742283 |
| 135 | MP0002210_abnormal_sex_determination | 0.68704033 |
| 136 | MP0004185_abnormal_adipocyte_glucose | 0.67627284 |
| 137 | MP0002118_abnormal_lipid_homeostasis | 0.66270734 |
| 138 | MP0000343_altered_response_to | 0.66111241 |
| 139 | MP0005501_abnormal_skin_physiology | 0.65816947 |
| 140 | MP0009697_abnormal_copulation | 0.65324128 |
| 141 | MP0005376_homeostasis/metabolism_phenot | 0.65029409 |
| 142 | MP0002638_abnormal_pupillary_reflex | 0.64655836 |
| 143 | MP0005319_abnormal_enzyme/_coenzyme | 0.64373397 |
| 144 | MP0005365_abnormal_bile_salt | 0.64209165 |
| 145 | MP0001346_abnormal_lacrimal_gland | 0.63817266 |
| 146 | MP0005645_abnormal_hypothalamus_physiol | 0.63756826 |
| 147 | MP0002066_abnormal_motor_capabilities/c | 0.63453814 |
| 148 | MP0001919_abnormal_reproductive_system | 0.63208850 |
| 149 | MP0005379_endocrine/exocrine_gland_phen | 0.59465886 |
| 150 | MP0001502_abnormal_circadian_rhythm | 0.58673440 |
| 151 | MP0000313_abnormal_cell_death | 0.57890288 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 7.03588021 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 6.64628875 |
| 3 | Acute encephalopathy (HP:0006846) | 6.07676003 |
| 4 | Progressive macrocephaly (HP:0004481) | 5.89288097 |
| 5 | Mitochondrial inheritance (HP:0001427) | 5.83113941 |
| 6 | Hepatocellular necrosis (HP:0001404) | 5.21592465 |
| 7 | Increased CSF lactate (HP:0002490) | 5.19689976 |
| 8 | Hepatic necrosis (HP:0002605) | 5.19414420 |
| 9 | Cerebral edema (HP:0002181) | 4.82519227 |
| 10 | Sudden death (HP:0001699) | 4.52811851 |
| 11 | Nemaline bodies (HP:0003798) | 4.24700376 |
| 12 | Muscle fiber inclusion bodies (HP:0100299) | 4.22133990 |
| 13 | Calf muscle hypertrophy (HP:0008981) | 4.20874638 |
| 14 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 4.06453658 |
| 15 | Muscle hypertrophy of the lower extremities (HP:0008968) | 4.03414739 |
| 16 | Lactic acidosis (HP:0003128) | 3.96975398 |
| 17 | Respiratory failure (HP:0002878) | 3.89798458 |
| 18 | Exercise intolerance (HP:0003546) | 3.84904109 |
| 19 | Abnormality of glycolysis (HP:0004366) | 3.81772695 |
| 20 | Increased serum pyruvate (HP:0003542) | 3.81772695 |
| 21 | Exercise-induced myalgia (HP:0003738) | 3.76531255 |
| 22 | Increased intramyocellular lipid droplets (HP:0012240) | 3.74199787 |
| 23 | Lipid accumulation in hepatocytes (HP:0006561) | 3.73085837 |
| 24 | Increased hepatocellular lipid droplets (HP:0006565) | 3.72748997 |
| 25 | Ventricular tachycardia (HP:0004756) | 3.68320971 |
| 26 | Increased muscle lipid content (HP:0009058) | 3.68038045 |
| 27 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.61635322 |
| 28 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.61635322 |
| 29 | Pheochromocytoma (HP:0002666) | 3.56837735 |
| 30 | Optic disc pallor (HP:0000543) | 3.56121524 |
| 31 | Palpitations (HP:0001962) | 3.56049768 |
| 32 | Testicular atrophy (HP:0000029) | 3.49898980 |
| 33 | Neuroendocrine neoplasm (HP:0100634) | 3.42363963 |
| 34 | Leukodystrophy (HP:0002415) | 3.41601892 |
| 35 | Myopathic facies (HP:0002058) | 3.38622551 |
| 36 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.37757837 |
| 37 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.36290293 |
| 38 | Myoglobinuria (HP:0002913) | 3.33859189 |
| 39 | Exercise-induced muscle cramps (HP:0003710) | 3.30070462 |
| 40 | Abnormal number of erythroid precursors (HP:0012131) | 3.25741450 |
| 41 | Abnormality of the calf musculature (HP:0001430) | 3.21023672 |
| 42 | Increased serum lactate (HP:0002151) | 3.16749994 |
| 43 | Atrial fibrillation (HP:0005110) | 3.16161251 |
| 44 | Reticulocytopenia (HP:0001896) | 3.14591629 |
| 45 | Progressive muscle weakness (HP:0003323) | 3.12386585 |
| 46 | Muscle fiber splitting (HP:0003555) | 3.11379612 |
| 47 | Renal Fanconi syndrome (HP:0001994) | 3.10389688 |
| 48 | Primary atrial arrhythmia (HP:0001692) | 2.97294662 |
| 49 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.97062814 |
| 50 | Dicarboxylic aciduria (HP:0003215) | 2.97062814 |
| 51 | Supraventricular tachycardia (HP:0004755) | 2.95538240 |
| 52 | Macrocytic anemia (HP:0001972) | 2.93982197 |
| 53 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.89517902 |
| 54 | Lipoatrophy (HP:0100578) | 2.87936860 |
| 55 | Lethargy (HP:0001254) | 2.87408870 |
| 56 | Supraventricular arrhythmia (HP:0005115) | 2.85983101 |
| 57 | Syncope (HP:0001279) | 2.79718200 |
| 58 | Rhabdomyolysis (HP:0003201) | 2.71731860 |
| 59 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.67145082 |
| 60 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.66959995 |
| 61 | 3-Methylglutaconic aciduria (HP:0003535) | 2.64660812 |
| 62 | Conjunctival hamartoma (HP:0100780) | 2.61440742 |
| 63 | Prolonged QT interval (HP:0001657) | 2.57881082 |
| 64 | Dilated cardiomyopathy (HP:0001644) | 2.57269888 |
| 65 | Ketoacidosis (HP:0001993) | 2.56391548 |
| 66 | Type 1 muscle fiber predominance (HP:0003803) | 2.54982797 |
| 67 | CNS demyelination (HP:0007305) | 2.54327384 |
| 68 | Myotonia (HP:0002486) | 2.52330438 |
| 69 | EMG: myopathic abnormalities (HP:0003458) | 2.47750214 |
| 70 | Ragged-red muscle fibers (HP:0003200) | 2.47296283 |
| 71 | Type I transferrin isoform profile (HP:0003642) | 2.42310027 |
| 72 | Muscle fiber atrophy (HP:0100295) | 2.42172386 |
| 73 | Hyporeflexia of lower limbs (HP:0002600) | 2.37534602 |
| 74 | X-linked dominant inheritance (HP:0001423) | 2.37069231 |
| 75 | Reduced antithrombin III activity (HP:0001976) | 2.35211011 |
| 76 | Generalized aminoaciduria (HP:0002909) | 2.34452759 |
| 77 | Methylmalonic aciduria (HP:0012120) | 2.34299430 |
| 78 | Glycosuria (HP:0003076) | 2.30892486 |
| 79 | Abnormality of urine glucose concentration (HP:0011016) | 2.30892486 |
| 80 | Vomiting (HP:0002013) | 2.30282359 |
| 81 | Hypoglycemic coma (HP:0001325) | 2.26595294 |
| 82 | Microvesicular hepatic steatosis (HP:0001414) | 2.25423182 |
| 83 | Respiratory difficulties (HP:0002880) | 2.24557313 |
| 84 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.20668178 |
| 85 | Abnormality of alanine metabolism (HP:0010916) | 2.20668178 |
| 86 | Hyperalaninemia (HP:0003348) | 2.20668178 |
| 87 | Ketosis (HP:0001946) | 2.19077283 |
| 88 | Bundle branch block (HP:0011710) | 2.17937469 |
| 89 | Type 2 muscle fiber atrophy (HP:0003554) | 2.17199546 |
| 90 | Emotional lability (HP:0000712) | 2.16215143 |
| 91 | Muscle stiffness (HP:0003552) | 2.15778692 |
| 92 | Right ventricular cardiomyopathy (HP:0011663) | 2.14541144 |
| 93 | Rectal fistula (HP:0100590) | 2.14460821 |
| 94 | Rectovaginal fistula (HP:0000143) | 2.14460821 |
| 95 | Left ventricular hypertrophy (HP:0001712) | 2.14073027 |
| 96 | Cerebral hemorrhage (HP:0001342) | 2.13677766 |
| 97 | Neoplasm of head and neck (HP:0012288) | 2.12706784 |
| 98 | Esophageal neoplasm (HP:0100751) | 2.12706784 |
| 99 | Exertional dyspnea (HP:0002875) | 2.12064669 |
| 100 | Ventricular arrhythmia (HP:0004308) | 2.11531062 |
| 101 | Calcaneovalgus deformity (HP:0001848) | 2.11311363 |
| 102 | Methylmalonic acidemia (HP:0002912) | 2.10701405 |
| 103 | Microretrognathia (HP:0000308) | 2.08805764 |
| 104 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.08504200 |
| 105 | Subaortic stenosis (HP:0001682) | 2.08504200 |
| 106 | Rib fusion (HP:0000902) | 2.07892746 |
| 107 | Absent thumb (HP:0009777) | 2.07516742 |
| 108 | Pallor (HP:0000980) | 2.06413556 |
| 109 | Ventricular fibrillation (HP:0001663) | 2.03951407 |
| 110 | Amniotic constriction ring (HP:0009775) | 2.03939253 |
| 111 | Abnormality of placental membranes (HP:0011409) | 2.03939253 |
| 112 | Abnormality of renal resorption (HP:0011038) | 2.01790984 |
| 113 | Metabolic acidosis (HP:0001942) | 2.01696068 |
| 114 | Heart block (HP:0012722) | 2.01334765 |
| 115 | Multiple enchondromatosis (HP:0005701) | 2.01290891 |
| 116 | Vaginal fistula (HP:0004320) | 1.98697835 |
| 117 | Asymmetric septal hypertrophy (HP:0001670) | 1.94844266 |
| 118 | Myokymia (HP:0002411) | 1.92440272 |
| 119 | Deformed tarsal bones (HP:0008119) | 1.92288894 |
| 120 | Aplastic anemia (HP:0001915) | 1.91946574 |
| 121 | Neck muscle weakness (HP:0000467) | 1.91481155 |
| 122 | Abnormal EKG (HP:0003115) | 1.90907121 |
| 123 | Birth length less than 3rd percentile (HP:0003561) | 1.88935646 |
| 124 | Cerebral hypomyelination (HP:0006808) | 1.86867545 |
| 125 | Proximal tubulopathy (HP:0000114) | 1.85773310 |
| 126 | Hyperammonemia (HP:0001987) | 1.85560809 |
| 127 | Focal motor seizures (HP:0011153) | 1.84976058 |
| 128 | Distal arthrogryposis (HP:0005684) | 1.84821176 |
| 129 | Abnormal atrioventricular conduction (HP:0005150) | 1.84074007 |
| 130 | Progressive external ophthalmoplegia (HP:0000590) | 1.81147365 |
| 131 | Gliosis (HP:0002171) | 1.80465387 |
| 132 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.80308706 |
| 133 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.80308706 |
| 134 | Abnormal protein glycosylation (HP:0012346) | 1.80308706 |
| 135 | Abnormal glycosylation (HP:0012345) | 1.80308706 |
| 136 | Oligomenorrhea (HP:0000876) | 1.79807780 |
| 137 | Atrioventricular block (HP:0001678) | 1.78759072 |
| 138 | Hyperglycinuria (HP:0003108) | 1.78017249 |
| 139 | Hyperphosphaturia (HP:0003109) | 1.77928011 |
| 140 | Hypoplastic heart (HP:0001961) | 1.77555176 |
| 141 | Absent phalangeal crease (HP:0006109) | 1.76438740 |
| 142 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.76110709 |
| 143 | Bulbar palsy (HP:0001283) | 1.74497787 |
| 144 | Progressive microcephaly (HP:0000253) | 1.69899132 |
| 145 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.69417668 |
| 146 | Hyperglycinemia (HP:0002154) | 1.66764493 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYLK | 4.16288608 |
| 2 | VRK2 | 3.88628431 |
| 3 | NME1 | 3.36916397 |
| 4 | PDK3 | 3.24981207 |
| 5 | PDK4 | 3.24981207 |
| 6 | TESK2 | 3.17539752 |
| 7 | BUB1 | 3.15255249 |
| 8 | OBSCN | 3.03451844 |
| 9 | BCKDK | 3.03267889 |
| 10 | PHKG1 | 2.85356840 |
| 11 | PHKG2 | 2.85356840 |
| 12 | MUSK | 2.77524359 |
| 13 | TTN | 2.65429731 |
| 14 | LMTK2 | 2.50451104 |
| 15 | MAP3K12 | 2.45080842 |
| 16 | GRK7 | 2.33328870 |
| 17 | TLK1 | 2.27260712 |
| 18 | NME2 | 2.24857900 |
| 19 | PDK2 | 2.22764497 |
| 20 | STK39 | 2.21032691 |
| 21 | WNK4 | 2.16605708 |
| 22 | CASK | 2.08105057 |
| 23 | PBK | 2.06262356 |
| 24 | PIK3CA | 2.03709435 |
| 25 | PINK1 | 1.96462059 |
| 26 | TESK1 | 1.84973564 |
| 27 | ARAF | 1.67569080 |
| 28 | OXSR1 | 1.67351206 |
| 29 | CDC7 | 1.67055118 |
| 30 | STK16 | 1.66108916 |
| 31 | SRPK1 | 1.63084851 |
| 32 | CAMK2D | 1.58023377 |
| 33 | GRK5 | 1.53747264 |
| 34 | MAP2K7 | 1.47888937 |
| 35 | VRK1 | 1.42209592 |
| 36 | LIMK1 | 1.40009212 |
| 37 | DYRK2 | 1.33969213 |
| 38 | AURKA | 1.28982741 |
| 39 | DAPK3 | 1.19867646 |
| 40 | NEK1 | 1.18406728 |
| 41 | MAP3K4 | 1.17854682 |
| 42 | CAMK2A | 1.17161448 |
| 43 | LRRK2 | 1.11692068 |
| 44 | SCYL2 | 1.11172002 |
| 45 | CDK19 | 1.09169330 |
| 46 | CAMK2G | 1.08856700 |
| 47 | PKN1 | 1.08837114 |
| 48 | ILK | 1.08715586 |
| 49 | MST1R | 1.07865357 |
| 50 | CCNB1 | 1.05467162 |
| 51 | TIE1 | 1.03201692 |
| 52 | MAPK12 | 1.02209055 |
| 53 | MST4 | 0.99382432 |
| 54 | CAMK2B | 0.98472483 |
| 55 | STK24 | 0.97284263 |
| 56 | PLK1 | 0.95718854 |
| 57 | EPHA4 | 0.94030410 |
| 58 | PNCK | 0.91345965 |
| 59 | MAP2K4 | 0.90619531 |
| 60 | MAPKAPK5 | 0.89624685 |
| 61 | ADRBK2 | 0.87106346 |
| 62 | AKT2 | 0.85570383 |
| 63 | MAPK15 | 0.84613823 |
| 64 | PAK3 | 0.84351668 |
| 65 | CSNK1G3 | 0.83367687 |
| 66 | ROCK2 | 0.83194975 |
| 67 | PRKCE | 0.81905497 |
| 68 | AURKB | 0.79946783 |
| 69 | PTK2B | 0.76469811 |
| 70 | RPS6KB2 | 0.76215924 |
| 71 | ADRBK1 | 0.75612093 |
| 72 | RPS6KA5 | 0.75253140 |
| 73 | TTK | 0.75013914 |
| 74 | BRSK1 | 0.74800636 |
| 75 | PRKACA | 0.74034089 |
| 76 | TRIM28 | 0.73054252 |
| 77 | PLK2 | 0.70037825 |
| 78 | ATR | 0.68960381 |
| 79 | CHEK2 | 0.68842887 |
| 80 | CSNK2A2 | 0.67876182 |
| 81 | DYRK3 | 0.67038672 |
| 82 | PAK1 | 0.67012002 |
| 83 | ROCK1 | 0.66534574 |
| 84 | BRAF | 0.63115284 |
| 85 | CSNK2A1 | 0.62815412 |
| 86 | CDK11A | 0.62771832 |
| 87 | ABL2 | 0.62491152 |
| 88 | TNIK | 0.61168634 |
| 89 | KDR | 0.59077261 |
| 90 | WNK3 | 0.58931075 |
| 91 | PRKD1 | 0.58844863 |
| 92 | CDK15 | 0.58096457 |
| 93 | UHMK1 | 0.56972337 |
| 94 | DMPK | 0.55634281 |
| 95 | CDK14 | 0.54727627 |
| 96 | BCR | 0.54657033 |
| 97 | PRKCG | 0.54607757 |
| 98 | STK4 | 0.54259269 |
| 99 | CDK18 | 0.54096725 |
| 100 | WNK1 | 0.53609014 |
| 101 | PRKCI | 0.52112312 |
| 102 | MINK1 | 0.50515026 |
| 103 | MARK1 | 0.50026691 |
| 104 | CAMK1 | 0.49557741 |
| 105 | PRKACB | 0.49552011 |
| 106 | MAP4K2 | 0.49200859 |
| 107 | CSNK1G2 | 0.47597622 |
| 108 | PAK4 | 0.46134363 |
| 109 | NUAK1 | 0.46108862 |
| 110 | STK38L | 0.45290270 |
| 111 | CSNK1G1 | 0.45092341 |
| 112 | BMPR1B | 0.44424487 |
| 113 | NTRK3 | 0.43085101 |
| 114 | PLK4 | 0.43017605 |
| 115 | PRKACG | 0.42205469 |
| 116 | EIF2AK3 | 0.42105687 |
| 117 | BMPR2 | 0.41078128 |
| 118 | MAP2K1 | 0.40946858 |
| 119 | EIF2AK1 | 0.40806122 |
| 120 | DYRK1B | 0.40569822 |
| 121 | CSNK1A1L | 0.40430149 |
| 122 | MAPK13 | 0.39243405 |
| 123 | SGK494 | 0.39101540 |
| 124 | SGK223 | 0.39101540 |
| 125 | PLK3 | 0.39035125 |
| 126 | CDK7 | 0.38663971 |
| 127 | INSRR | 0.38032334 |
| 128 | CDK8 | 0.37640975 |
| 129 | RPS6KC1 | 0.35412090 |
| 130 | RPS6KL1 | 0.35412090 |
| 131 | EEF2K | 0.35267519 |
| 132 | CHEK1 | 0.35197338 |
| 133 | CDC42BPA | 0.34045543 |
| 134 | PDPK1 | 0.33722250 |
| 135 | MAPK4 | 0.33503296 |
| 136 | CDK5 | 0.33326918 |
| 137 | TAOK2 | 0.33225208 |
| 138 | PIK3CG | 0.32934587 |
| 139 | ZAK | 0.32335403 |
| 140 | CSNK1E | 0.31944975 |
| 141 | DAPK1 | 0.31535555 |
| 142 | MAPKAPK3 | 0.31305299 |
| 143 | PRKCA | 0.30657768 |
| 144 | PRKAA2 | 0.29209129 |
| 145 | MAP2K6 | 0.28984132 |
| 146 | PRKG1 | 0.28975484 |
| 147 | MAP3K8 | 0.28741225 |
| 148 | SMG1 | 0.28668202 |
| 149 | GRK6 | 0.28615849 |
| 150 | MAP3K11 | 0.28203346 |
| 151 | PRKCQ | 0.28199068 |
| 152 | PIM2 | 0.27446989 |
| 153 | PRKAA1 | 0.27360311 |
| 154 | CAMK4 | 0.26973688 |
| 155 | GRK1 | 0.26940739 |
| 156 | TRIB3 | 0.24675882 |
| 157 | CDK2 | 0.23530991 |
| 158 | PRKD3 | 0.23431394 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.81184980 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 5.14210920 |
| 3 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 4.23414598 |
| 4 | Alzheimers disease_Homo sapiens_hsa05010 | 3.85174461 |
| 5 | Huntingtons disease_Homo sapiens_hsa05016 | 3.45487892 |
| 6 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.43754924 |
| 7 | * Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 3.25530309 |
| 8 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.70057260 |
| 9 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.69814699 |
| 10 | DNA replication_Homo sapiens_hsa03030 | 2.59103333 |
| 11 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.19530719 |
| 12 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.12769609 |
| 13 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.07303978 |
| 14 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.06556134 |
| 15 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.01100975 |
| 16 | Base excision repair_Homo sapiens_hsa03410 | 1.99012369 |
| 17 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.91960526 |
| 18 | Mismatch repair_Homo sapiens_hsa03430 | 1.87604335 |
| 19 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.87077418 |
| 20 | Carbon metabolism_Homo sapiens_hsa01200 | 1.86826736 |
| 21 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.80132447 |
| 22 | Proteasome_Homo sapiens_hsa03050 | 1.74779485 |
| 23 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.72371851 |
| 24 | Ribosome_Homo sapiens_hsa03010 | 1.65708494 |
| 25 | Homologous recombination_Homo sapiens_hsa03440 | 1.64771871 |
| 26 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.62289195 |
| 27 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.52877397 |
| 28 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.51369053 |
| 29 | Spliceosome_Homo sapiens_hsa03040 | 1.45899449 |
| 30 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.41071287 |
| 31 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.37721282 |
| 32 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.34888787 |
| 33 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.31074367 |
| 34 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.27380883 |
| 35 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.15302921 |
| 36 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.13995190 |
| 37 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.13068614 |
| 38 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.12048008 |
| 39 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.10620654 |
| 40 | RNA transport_Homo sapiens_hsa03013 | 1.10426376 |
| 41 | Peroxisome_Homo sapiens_hsa04146 | 1.09038512 |
| 42 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.01899970 |
| 43 | Protein export_Homo sapiens_hsa03060 | 0.95106583 |
| 44 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.93134906 |
| 45 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.92397963 |
| 46 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.91991385 |
| 47 | RNA degradation_Homo sapiens_hsa03018 | 0.89862710 |
| 48 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.85855051 |
| 49 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.85460834 |
| 50 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.83291236 |
| 51 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.79996390 |
| 52 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.78359433 |
| 53 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.77972845 |
| 54 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.76072047 |
| 55 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.75472316 |
| 56 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.75423185 |
| 57 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.75336445 |
| 58 | Nicotine addiction_Homo sapiens_hsa05033 | 0.71271302 |
| 59 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.70832605 |
| 60 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.66645593 |
| 61 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.66536725 |
| 62 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.64704448 |
| 63 | RNA polymerase_Homo sapiens_hsa03020 | 0.61639582 |
| 64 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.61611910 |
| 65 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.61438443 |
| 66 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.61167749 |
| 67 | Basal transcription factors_Homo sapiens_hsa03022 | 0.60245813 |
| 68 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.57254374 |
| 69 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.56733485 |
| 70 | Histidine metabolism_Homo sapiens_hsa00340 | 0.55796680 |
| 71 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.54375677 |
| 72 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.54145764 |
| 73 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.51643705 |
| 74 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.51306475 |
| 75 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.51201902 |
| 76 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.50553182 |
| 77 | GABAergic synapse_Homo sapiens_hsa04727 | 0.50372211 |
| 78 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.50170531 |
| 79 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.49848134 |
| 80 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.48922696 |
| 81 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.44456680 |
| 82 | Taste transduction_Homo sapiens_hsa04742 | 0.43455327 |
| 83 | Sulfur relay system_Homo sapiens_hsa04122 | 0.43234718 |
| 84 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.41528038 |
| 85 | Cell cycle_Homo sapiens_hsa04110 | 0.40620321 |
| 86 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.39158430 |
| 87 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.35096466 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.33274774 |
| 89 | Circadian entrainment_Homo sapiens_hsa04713 | 0.33128043 |
| 90 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.32736724 |
| 91 | Morphine addiction_Homo sapiens_hsa05032 | 0.31295630 |
| 92 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.30392939 |
| 93 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.29882411 |
| 94 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.29664770 |
| 95 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.29316484 |
| 96 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.29010959 |
| 97 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.28575784 |
| 98 | Galactose metabolism_Homo sapiens_hsa00052 | 0.28093868 |
| 99 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.27374669 |
| 100 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.27139192 |
| 101 | Renin secretion_Homo sapiens_hsa04924 | 0.27081218 |
| 102 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26564802 |
| 103 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.26083203 |
| 104 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.25700556 |
| 105 | Purine metabolism_Homo sapiens_hsa00230 | 0.24659566 |
| 106 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.22623807 |
| 107 | Salivary secretion_Homo sapiens_hsa04970 | 0.22497110 |
| 108 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.22358248 |
| 109 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.21859146 |
| 110 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.21442766 |
| 111 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.21021249 |
| 112 | Olfactory transduction_Homo sapiens_hsa04740 | 0.20816042 |
| 113 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.20265114 |
| 114 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.20180262 |
| 115 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.20033298 |
| 116 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.19738769 |
| 117 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.19670566 |
| 118 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.19260032 |
| 119 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.18927066 |
| 120 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.18797953 |
| 121 | Phototransduction_Homo sapiens_hsa04744 | 0.18513432 |
| 122 | Insulin secretion_Homo sapiens_hsa04911 | 0.18024687 |
| 123 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.17039755 |
| 124 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.16225626 |
| 125 | Bile secretion_Homo sapiens_hsa04976 | 0.15814540 |
| 126 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.15068407 |
| 127 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.14954244 |
| 128 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.14888584 |
| 129 | Alcoholism_Homo sapiens_hsa05034 | 0.14236445 |
| 130 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.13823027 |
| 131 | Retinol metabolism_Homo sapiens_hsa00830 | 0.12246738 |
| 132 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.11002970 |
| 133 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.10037394 |
| 134 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.09912281 |
| 135 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.08987165 |
| 136 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.08779455 |

