NDUFB10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.42771770
2ATP synthesis coupled proton transport (GO:0015986)8.85080938
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.85080938
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.60020342
5* respiratory electron transport chain (GO:0022904)8.00933723
6* electron transport chain (GO:0022900)7.81330793
7ribosomal small subunit biogenesis (GO:0042274)7.02222752
8tricarboxylic acid cycle (GO:0006099)5.97032553
9maturation of SSU-rRNA (GO:0030490)5.80841794
10oxidative phosphorylation (GO:0006119)5.58804402
11viral transcription (GO:0019083)5.51038357
12ATP biosynthetic process (GO:0006754)5.29068627
13translational termination (GO:0006415)5.23210293
14ribosomal small subunit assembly (GO:0000028)4.97728176
15NADH metabolic process (GO:0006734)4.92948586
16translational elongation (GO:0006414)4.72016675
17purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.69162883
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.65484428
19purine nucleoside triphosphate biosynthetic process (GO:0009145)4.64757926
20hydrogen ion transmembrane transport (GO:1902600)4.59899908
21inner mitochondrial membrane organization (GO:0007007)4.55738943
22cotranslational protein targeting to membrane (GO:0006613)4.55220416
23protein targeting to ER (GO:0045047)4.53133473
24sarcomere organization (GO:0045214)4.51912378
25protein complex biogenesis (GO:0070271)4.41219867
26regulation of acyl-CoA biosynthetic process (GO:0050812)4.38458191
27establishment of protein localization to endoplasmic reticulum (GO:0072599)4.34349939
28protein localization to endoplasmic reticulum (GO:0070972)4.32859235
29regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.30208019
30succinate metabolic process (GO:0006105)4.25925134
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.24765656
32mitochondrial respiratory chain complex I assembly (GO:0032981)4.24765656
33NADH dehydrogenase complex assembly (GO:0010257)4.24765656
34positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.23963769
35rRNA modification (GO:0000154)4.22338323
36viral life cycle (GO:0019058)4.22104440
37pseudouridine synthesis (GO:0001522)4.19110134
38chaperone-mediated protein transport (GO:0072321)4.12061770
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.10279898
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.09126206
41ribonucleoside triphosphate biosynthetic process (GO:0009201)4.09063404
42translation (GO:0006412)4.08887114
43cellular protein complex disassembly (GO:0043624)4.06723008
44mitochondrial respiratory chain complex assembly (GO:0033108)4.06053896
45ribosomal large subunit biogenesis (GO:0042273)4.05859487
46proteasome assembly (GO:0043248)4.04593401
47proton transport (GO:0015992)4.03925889
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.02479661
49translational initiation (GO:0006413)4.02308472
50respiratory chain complex IV assembly (GO:0008535)4.00897608
51hydrogen transport (GO:0006818)3.99209860
52regulation of coenzyme metabolic process (GO:0051196)3.99084239
53regulation of cofactor metabolic process (GO:0051193)3.99084239
54establishment of protein localization to mitochondrion (GO:0072655)3.98855252
55negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.97805618
56GDP-mannose metabolic process (GO:0019673)3.94346534
57ribonucleoprotein complex biogenesis (GO:0022613)3.94241042
58aerobic respiration (GO:0009060)3.91457795
59cellular component biogenesis (GO:0044085)3.90206373
60regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.87897704
61cytochrome complex assembly (GO:0017004)3.82932249
62regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.82831235
63protein localization to mitochondrion (GO:0070585)3.79870439
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.76876568
65termination of RNA polymerase III transcription (GO:0006386)3.76876568
66cardiac myofibril assembly (GO:0055003)3.75664642
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.75384366
68ubiquinone biosynthetic process (GO:0006744)3.74238747
69quinone biosynthetic process (GO:1901663)3.74238747
70metallo-sulfur cluster assembly (GO:0031163)3.74129002
71iron-sulfur cluster assembly (GO:0016226)3.74129002
72actin-myosin filament sliding (GO:0033275)3.72592936
73muscle filament sliding (GO:0030049)3.72592936
74regulation of oxidative phosphorylation (GO:0002082)3.70259832
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69810276
76regulation of cell communication by electrical coupling (GO:0010649)3.63482142
77regulation of mitochondrial translation (GO:0070129)3.60954002
78regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.59005799
79oxaloacetate metabolic process (GO:0006107)3.58207370
80myofibril assembly (GO:0030239)3.56184605
81protein complex disassembly (GO:0043241)3.55440865
82cardiac muscle contraction (GO:0060048)3.53665069
83regulation of relaxation of muscle (GO:1901077)3.53629551
84nucleoside triphosphate biosynthetic process (GO:0009142)3.51252370
85heart contraction (GO:0060047)3.49851231
86heart process (GO:0003015)3.49851231
87cullin deneddylation (GO:0010388)3.47362163
88base-excision repair, AP site formation (GO:0006285)3.45383155
89regulation of actin filament-based movement (GO:1903115)3.43799044
90negative regulation of ligase activity (GO:0051352)3.43171879
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43171879
92rRNA processing (GO:0006364)3.41946722
93negative regulation of potassium ion transmembrane transport (GO:1901380)3.40846878
94macromolecular complex disassembly (GO:0032984)3.40095535
95pyrimidine nucleotide catabolic process (GO:0006244)3.35723440
96peptidyl-histidine modification (GO:0018202)3.34287712
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34107478
98* generation of precursor metabolites and energy (GO:0006091)3.34081407
99protein deneddylation (GO:0000338)3.32004173
100ubiquinone metabolic process (GO:0006743)3.31989099
101rRNA methylation (GO:0031167)3.28067779
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27328504
103rRNA metabolic process (GO:0016072)3.24775528
104regulation of cellular amino acid metabolic process (GO:0006521)3.24443715
105mitochondrial transport (GO:0006839)3.24023947
106purine nucleoside monophosphate biosynthetic process (GO:0009127)3.23720785
107purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.23720785
108cellular ketone body metabolic process (GO:0046950)3.23490673
109pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.23065617
110GTP biosynthetic process (GO:0006183)3.21654559
111regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.18671428
112sarcoplasmic reticulum calcium ion transport (GO:0070296)3.18178384
113cellular respiration (GO:0045333)3.16730160
114deoxyribonucleotide catabolic process (GO:0009264)3.16494278
115regulation of cellular respiration (GO:0043457)3.15436417
116protein targeting to membrane (GO:0006612)3.15187298
117ATP hydrolysis coupled proton transport (GO:0015991)3.14754018
118energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.14754018
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14587023
120aspartate family amino acid catabolic process (GO:0009068)3.14361694
121regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.14205973
122protein neddylation (GO:0045116)3.12425627
123pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.11389114
124guanosine-containing compound biosynthetic process (GO:1901070)3.09003363
125regulation of sulfur metabolic process (GO:0042762)3.08527120
126formation of translation preinitiation complex (GO:0001731)3.05534539
127pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.02366664
128ventricular cardiac muscle cell action potential (GO:0086005)3.00958968
129DNA replication checkpoint (GO:0000076)2.99993381
130deoxyribose phosphate catabolic process (GO:0046386)2.98123132
131branched-chain amino acid catabolic process (GO:0009083)2.97749316
132actin-mediated cell contraction (GO:0070252)2.97164079
133nuclear-transcribed mRNA catabolic process (GO:0000956)2.97078930
134UTP biosynthetic process (GO:0006228)2.96920505
135nucleoside monophosphate biosynthetic process (GO:0009124)2.96565289
136regulation of skeletal muscle contraction (GO:0014819)2.96375851
1372-oxoglutarate metabolic process (GO:0006103)2.95745362
138positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95712772
139DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94004257
140cardiac muscle tissue morphogenesis (GO:0055008)2.93281181
141fatty acid beta-oxidation (GO:0006635)2.92774595
142adult heart development (GO:0007512)2.91986806
143regulation of sequestering of triglyceride (GO:0010889)2.90163568
144regulation of striated muscle contraction (GO:0006942)2.88392664
145cardiac muscle cell development (GO:0055013)2.85530160
146striated muscle contraction (GO:0006941)2.85043216
147ketone body metabolic process (GO:1902224)2.82303181
148response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.81799518
149regulation of membrane repolarization (GO:0060306)2.81093879
150negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80891772
151negative regulation of protein localization to cell surface (GO:2000009)2.79935290
152creatine metabolic process (GO:0006600)2.79535732
153fatty acid catabolic process (GO:0009062)2.76693166
154ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.76575945
155purine ribonucleoside biosynthetic process (GO:0046129)2.76312075
156purine nucleoside biosynthetic process (GO:0042451)2.76312075
157carnitine shuttle (GO:0006853)2.75778435
158short-chain fatty acid metabolic process (GO:0046459)2.74949905
159bundle of His cell to Purkinje myocyte communication (GO:0086069)2.73480470
160lysine catabolic process (GO:0006554)2.73313436
161lysine metabolic process (GO:0006553)2.73313436
162dopamine transport (GO:0015872)2.70606790
163detection of calcium ion (GO:0005513)2.67634387
164protein targeting to mitochondrion (GO:0006626)2.63084238
165muscle tissue morphogenesis (GO:0060415)2.62896489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.91630261
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.38409743
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.64821830
4EZH2_22144423_ChIP-Seq_EOC_Human3.13463250
5MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00566739
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98511286
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87556337
8XRN2_22483619_ChIP-Seq_HELA_Human2.86229533
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68049288
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65307966
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.64845145
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49755402
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39681350
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.32939856
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.27921399
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19551962
17* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18789239
18* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18703274
19GABP_19822575_ChIP-Seq_HepG2_Human2.17668634
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.13677250
21VDR_22108803_ChIP-Seq_LS180_Human2.08617611
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.03348293
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02691192
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.02258688
25E2F7_22180533_ChIP-Seq_HELA_Human1.99398488
26* TTF2_22483619_ChIP-Seq_HELA_Human1.97048784
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96743787
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92171869
29TAF15_26573619_Chip-Seq_HEK293_Human1.86460005
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83011275
31* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80800806
32VDR_23849224_ChIP-Seq_CD4+_Human1.79441338
33FOXP3_21729870_ChIP-Seq_TREG_Human1.78771421
34* ETS1_20019798_ChIP-Seq_JURKAT_Human1.74886588
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74633705
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72521179
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.72449973
38* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72129619
39GBX2_23144817_ChIP-Seq_PC3_Human1.71972897
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71166186
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.66330888
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63838982
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.62859182
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61473377
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.60713466
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59319539
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53357074
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.50239379
49VDR_21846776_ChIP-Seq_THP-1_Human1.49429017
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49248917
51* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49192714
52* FOXP1_21924763_ChIP-Seq_HESCs_Human1.44429361
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.43377275
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43308882
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42655867
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40755865
57P68_20966046_ChIP-Seq_HELA_Human1.38797681
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38597056
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34974933
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33339714
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.32441529
62* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32211033
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31285959
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30129881
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29646563
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28887604
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28877079
68HTT_18923047_ChIP-ChIP_STHdh_Human1.26280722
69KDM5A_27292631_Chip-Seq_BREAST_Human1.26132150
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25658365
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25199482
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.22359282
73LXR_22292898_ChIP-Seq_THP-1_Human1.21678361
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21529134
75BCL6_27268052_Chip-Seq_Bcells_Human1.20691357
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18700419
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17527689
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.17274644
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.17184103
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16965919
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16677827
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16194717
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15767922
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.15270254
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15241984
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14324195
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14243021
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13827762
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13176314
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13049161
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12274972
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11670187
93* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11231298
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10961687
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.09770141
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09736137
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07913554
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07846687
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07819505
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07814527
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07324415
102CIITA_25753668_ChIP-Seq_RAJI_Human1.07251466
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06714730
104EZH2_27294783_Chip-Seq_ESCs_Mouse1.06115277
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06076531
106* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05792484
107EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05504422
108RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05504422
109E2F1_20622854_ChIP-Seq_HELA_Human1.05357189
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05149329
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04951608
112BP1_19119308_ChIP-ChIP_Hs578T_Human1.04851329
113REST_21632747_ChIP-Seq_MESCs_Mouse1.04542533
114* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03817454
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03662605
116TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03206829
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03116284
118ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02626673
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02442353
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02298829
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02005720
122PHF8_20622854_ChIP-Seq_HELA_Human1.01573144
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01331723
124EED_16625203_ChIP-ChIP_MESCs_Mouse1.01238658
125SA1_27219007_Chip-Seq_Bcells_Human1.01086284
126HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00351928
127OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98997356
128BCOR_27268052_Chip-Seq_Bcells_Human0.98824966
129EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98786650
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.98119195
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97185644
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97094633
133MYC_18940864_ChIP-ChIP_HL60_Human0.96812300
134MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96716851
135ER_23166858_ChIP-Seq_MCF-7_Human0.95754649
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95264427
137RARB_24833708_ChIP-Seq_LIVER_Mouse0.95109694
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94706724
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.94680366
140CTCF_21964334_Chip-Seq_Bcells_Human0.94265683
141* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94038273
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93407233
143SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93057265
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93037878
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92575661
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91338426
147CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91099841
148CTCF_20526341_ChIP-Seq_ESCs_Human0.90919223
149ZNF274_21170338_ChIP-Seq_K562_Hela0.90308932
150ZNF263_19887448_ChIP-Seq_K562_Human0.89540102
151ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87883283
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.87700936
153TBX20_22328084_ChIP-Seq_HEART_Mouse0.87270503
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.87270503
155NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86985290
156SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86901800
157MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84856806
158SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84334218
159PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84113227
160CTCF_27219007_Chip-Seq_Bcells_Human0.83507541
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81936703
162SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81936019
163DCP1A_22483619_ChIP-Seq_HELA_Human0.80719743
164MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80673890
165MYC_19829295_ChIP-Seq_ESCs_Human0.80029323
166AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79782479
167TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78900710
168NANOG_20526341_ChIP-Seq_ESCs_Human0.78505666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.02765678
2MP0003646_muscle_fatigue4.80434708
3MP0000751_myopathy4.11554969
4MP0004215_abnormal_myocardial_fiber3.61123578
5MP0004084_abnormal_cardiac_muscle3.59333563
6MP0004036_abnormal_muscle_relaxation3.26246869
7MP0000749_muscle_degeneration3.17578214
8MP0006036_abnormal_mitochondrial_physio3.00055546
9MP0005330_cardiomyopathy2.89379047
10MP0003693_abnormal_embryo_hatching2.59289484
11MP0001529_abnormal_vocalization2.54550507
12MP0001188_hyperpigmentation2.46804053
13MP0003880_abnormal_central_pattern2.43187989
14MP0002822_catalepsy2.36358481
15MP0003137_abnormal_impulse_conducting2.32885146
16MP0002972_abnormal_cardiac_muscle2.23804238
17MP0005423_abnormal_somatic_nervous2.23777936
18MP0006035_abnormal_mitochondrial_morpho2.13795480
19MP0004957_abnormal_blastocyst_morpholog2.10490563
20MP0004484_altered_response_of2.07042948
21MP0006292_abnormal_olfactory_placode2.03060904
22MP0005620_abnormal_muscle_contractility1.98575828
23MP0008058_abnormal_DNA_repair1.97644579
24MP0001986_abnormal_taste_sensitivity1.96563615
25MP0004145_abnormal_muscle_electrophysio1.95157966
26MP0004130_abnormal_muscle_cell1.91318717
27MP0008775_abnormal_heart_ventricle1.87316936
28MP0003111_abnormal_nucleus_morphology1.85529237
29MP0004087_abnormal_muscle_fiber1.82640393
30MP0003786_premature_aging1.82257457
31MP0008932_abnormal_embryonic_tissue1.79734861
32MP0004085_abnormal_heartbeat1.73635612
33MP0001544_abnormal_cardiovascular_syste1.72666115
34MP0005385_cardiovascular_system_phenoty1.72666115
35MP0002106_abnormal_muscle_physiology1.72224974
36MP0003806_abnormal_nucleotide_metabolis1.71121903
37MP0001905_abnormal_dopamine_level1.70555166
38MP0000750_abnormal_muscle_regeneration1.69586898
39MP0002332_abnormal_exercise_endurance1.67586931
40MP0006276_abnormal_autonomic_nervous1.65107613
41MP0004043_abnormal_pH_regulation1.64969744
42MP0000747_muscle_weakness1.64894006
43MP0006138_congestive_heart_failure1.61003840
44MP0002160_abnormal_reproductive_system1.60711054
45MP0003123_paternal_imprinting1.59872744
46MP0008789_abnormal_olfactory_epithelium1.59790512
47MP0010094_abnormal_chromosome_stability1.57091088
48MP0010030_abnormal_orbit_morphology1.54558908
49MP0005171_absent_coat_pigmentation1.54408362
50MP0002269_muscular_atrophy1.52860275
51MP0003195_calcinosis1.47169588
52MP0004142_abnormal_muscle_tone1.46727858
53MP0003077_abnormal_cell_cycle1.43332199
54MP0005369_muscle_phenotype1.41528806
55MP0001661_extended_life_span1.40789030
56MP0002163_abnormal_gland_morphology1.39358169
57MP0005085_abnormal_gallbladder_physiolo1.38907774
58MP0009046_muscle_twitch1.37153397
59MP0003011_delayed_dark_adaptation1.36025370
60MP0002272_abnormal_nervous_system1.35536549
61MP0000759_abnormal_skeletal_muscle1.34625385
62MP0009745_abnormal_behavioral_response1.33842412
63MP0008875_abnormal_xenobiotic_pharmacok1.33402589
64MP0000372_irregular_coat_pigmentation1.32758706
65MP0002064_seizures1.30977439
66MP0002736_abnormal_nociception_after1.29339093
67MP0003221_abnormal_cardiomyocyte_apopto1.25745042
68MP0002139_abnormal_hepatobiliary_system1.25103215
69MP0001440_abnormal_grooming_behavior1.24178020
70MP0005332_abnormal_amino_acid1.23870915
71MP0004924_abnormal_behavior1.23029489
72MP0005386_behavior/neurological_phenoty1.23029489
73MP0008995_early_reproductive_senescence1.21042514
74MP0005670_abnormal_white_adipose1.20110969
75MP0005535_abnormal_body_temperature1.19252429
76MP0009379_abnormal_foot_pigmentation1.18792179
77MP0004147_increased_porphyrin_level1.18627926
78MP0001968_abnormal_touch/_nociception1.16055875
79MP0005266_abnormal_metabolism1.12834009
80MP0001764_abnormal_homeostasis1.12530771
81MP0010630_abnormal_cardiac_muscle1.11916123
82MP0003635_abnormal_synaptic_transmissio1.11152867
83MP0000678_abnormal_parathyroid_gland1.10270874
84MP0005083_abnormal_biliary_tract1.07463219
85MP0000230_abnormal_systemic_arterial1.07261728
86MP0005360_urolithiasis1.06252682
87MP0003950_abnormal_plasma_membrane1.05698926
88MP0005174_abnormal_tail_pigmentation1.05390784
89MP0002127_abnormal_cardiovascular_syste1.03724613
90MP0002735_abnormal_chemical_nociception1.00747773
91MP0000049_abnormal_middle_ear1.00732281
92MP0005394_taste/olfaction_phenotype1.00376663
93MP0005499_abnormal_olfactory_system1.00376663
94MP0003718_maternal_effect0.99347510
95MP0005451_abnormal_body_composition0.98446954
96MP0005165_increased_susceptibility_to0.96559112
97MP0000013_abnormal_adipose_tissue0.96376910
98MP0008007_abnormal_cellular_replicative0.95695943
99MP0003315_abnormal_perineum_morphology0.95114485
100MP0000358_abnormal_cell_content/0.94609406
101MP0002572_abnormal_emotion/affect_behav0.93806355
102MP0002876_abnormal_thyroid_physiology0.92896555
103MP0004270_analgesia0.90527253
104MP0005666_abnormal_adipose_tissue0.88851549
105MP0001501_abnormal_sleep_pattern0.88809026
106MP0001970_abnormal_pain_threshold0.88510833
107MP0004233_abnormal_muscle_weight0.87933045
108MP0005646_abnormal_pituitary_gland0.87911830
109MP0002909_abnormal_adrenal_gland0.87419972
110MP0002067_abnormal_sensory_capabilities0.87217297
111MP0005584_abnormal_enzyme/coenzyme_acti0.86914839
112MP0003186_abnormal_redox_activity0.86534022
113MP0002734_abnormal_mechanical_nocicepti0.86425079
114MP0002234_abnormal_pharynx_morphology0.86163800
115MP0002938_white_spotting0.85186223
116MP0005084_abnormal_gallbladder_morpholo0.84134694
117MP0003828_pulmonary_edema0.81875042
118MP0002063_abnormal_learning/memory/cond0.80535704
119MP0008872_abnormal_physiological_respon0.80446833
120MP0001486_abnormal_startle_reflex0.78953854
121MP0005389_reproductive_system_phenotype0.78855476
122MP0003136_yellow_coat_color0.78852715
123MP0002249_abnormal_larynx_morphology0.77900776
124MP0001727_abnormal_embryo_implantation0.77748367
125MP0003329_amyloid_beta_deposits0.76054770
126MP0002277_abnormal_respiratory_mucosa0.75859974
127MP0004858_abnormal_nervous_system0.75408532
128MP0000538_abnormal_urinary_bladder0.74205216
129MP0005636_abnormal_mineral_homeostasis0.74200024
130MP0002733_abnormal_thermal_nociception0.73591191
131MP0001984_abnormal_olfaction0.71304379
132MP0004859_abnormal_synaptic_plasticity0.70754217
133MP0001756_abnormal_urination0.68960336
134MP0003656_abnormal_erythrocyte_physiolo0.68742283
135MP0002210_abnormal_sex_determination0.68704033
136MP0004185_abnormal_adipocyte_glucose0.67627284
137MP0002118_abnormal_lipid_homeostasis0.66270734
138MP0000343_altered_response_to0.66111241
139MP0005501_abnormal_skin_physiology0.65816947
140MP0009697_abnormal_copulation0.65324128
141MP0005376_homeostasis/metabolism_phenot0.65029409
142MP0002638_abnormal_pupillary_reflex0.64655836
143MP0005319_abnormal_enzyme/_coenzyme0.64373397
144MP0005365_abnormal_bile_salt0.64209165
145MP0001346_abnormal_lacrimal_gland0.63817266
146MP0005645_abnormal_hypothalamus_physiol0.63756826
147MP0002066_abnormal_motor_capabilities/c0.63453814
148MP0001919_abnormal_reproductive_system0.63208850
149MP0005379_endocrine/exocrine_gland_phen0.59465886
150MP0001502_abnormal_circadian_rhythm0.58673440
151MP0000313_abnormal_cell_death0.57890288

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.03588021
2Abnormal mitochondria in muscle tissue (HP:0008316)6.64628875
3Acute encephalopathy (HP:0006846)6.07676003
4Progressive macrocephaly (HP:0004481)5.89288097
5Mitochondrial inheritance (HP:0001427)5.83113941
6Hepatocellular necrosis (HP:0001404)5.21592465
7Increased CSF lactate (HP:0002490)5.19689976
8Hepatic necrosis (HP:0002605)5.19414420
9Cerebral edema (HP:0002181)4.82519227
10Sudden death (HP:0001699)4.52811851
11Nemaline bodies (HP:0003798)4.24700376
12Muscle fiber inclusion bodies (HP:0100299)4.22133990
13Calf muscle hypertrophy (HP:0008981)4.20874638
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.06453658
15Muscle hypertrophy of the lower extremities (HP:0008968)4.03414739
16Lactic acidosis (HP:0003128)3.96975398
17Respiratory failure (HP:0002878)3.89798458
18Exercise intolerance (HP:0003546)3.84904109
19Abnormality of glycolysis (HP:0004366)3.81772695
20Increased serum pyruvate (HP:0003542)3.81772695
21Exercise-induced myalgia (HP:0003738)3.76531255
22Increased intramyocellular lipid droplets (HP:0012240)3.74199787
23Lipid accumulation in hepatocytes (HP:0006561)3.73085837
24Increased hepatocellular lipid droplets (HP:0006565)3.72748997
25Ventricular tachycardia (HP:0004756)3.68320971
26Increased muscle lipid content (HP:0009058)3.68038045
27Decreased activity of mitochondrial respiratory chain (HP:0008972)3.61635322
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.61635322
29Pheochromocytoma (HP:0002666)3.56837735
30Optic disc pallor (HP:0000543)3.56121524
31Palpitations (HP:0001962)3.56049768
32Testicular atrophy (HP:0000029)3.49898980
33Neuroendocrine neoplasm (HP:0100634)3.42363963
34Leukodystrophy (HP:0002415)3.41601892
35Myopathic facies (HP:0002058)3.38622551
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.37757837
37Abnormality of cells of the erythroid lineage (HP:0012130)3.36290293
38Myoglobinuria (HP:0002913)3.33859189
39Exercise-induced muscle cramps (HP:0003710)3.30070462
40Abnormal number of erythroid precursors (HP:0012131)3.25741450
41Abnormality of the calf musculature (HP:0001430)3.21023672
42Increased serum lactate (HP:0002151)3.16749994
43Atrial fibrillation (HP:0005110)3.16161251
44Reticulocytopenia (HP:0001896)3.14591629
45Progressive muscle weakness (HP:0003323)3.12386585
46Muscle fiber splitting (HP:0003555)3.11379612
47Renal Fanconi syndrome (HP:0001994)3.10389688
48Primary atrial arrhythmia (HP:0001692)2.97294662
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97062814
50Dicarboxylic aciduria (HP:0003215)2.97062814
51Supraventricular tachycardia (HP:0004755)2.95538240
52Macrocytic anemia (HP:0001972)2.93982197
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89517902
54Lipoatrophy (HP:0100578)2.87936860
55Lethargy (HP:0001254)2.87408870
56Supraventricular arrhythmia (HP:0005115)2.85983101
57Syncope (HP:0001279)2.79718200
58Rhabdomyolysis (HP:0003201)2.71731860
59Abnormality of fatty-acid metabolism (HP:0004359)2.67145082
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.66959995
613-Methylglutaconic aciduria (HP:0003535)2.64660812
62Conjunctival hamartoma (HP:0100780)2.61440742
63Prolonged QT interval (HP:0001657)2.57881082
64Dilated cardiomyopathy (HP:0001644)2.57269888
65Ketoacidosis (HP:0001993)2.56391548
66Type 1 muscle fiber predominance (HP:0003803)2.54982797
67CNS demyelination (HP:0007305)2.54327384
68Myotonia (HP:0002486)2.52330438
69EMG: myopathic abnormalities (HP:0003458)2.47750214
70Ragged-red muscle fibers (HP:0003200)2.47296283
71Type I transferrin isoform profile (HP:0003642)2.42310027
72Muscle fiber atrophy (HP:0100295)2.42172386
73Hyporeflexia of lower limbs (HP:0002600)2.37534602
74X-linked dominant inheritance (HP:0001423)2.37069231
75Reduced antithrombin III activity (HP:0001976)2.35211011
76Generalized aminoaciduria (HP:0002909)2.34452759
77Methylmalonic aciduria (HP:0012120)2.34299430
78Glycosuria (HP:0003076)2.30892486
79Abnormality of urine glucose concentration (HP:0011016)2.30892486
80Vomiting (HP:0002013)2.30282359
81Hypoglycemic coma (HP:0001325)2.26595294
82Microvesicular hepatic steatosis (HP:0001414)2.25423182
83Respiratory difficulties (HP:0002880)2.24557313
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20668178
85Abnormality of alanine metabolism (HP:0010916)2.20668178
86Hyperalaninemia (HP:0003348)2.20668178
87Ketosis (HP:0001946)2.19077283
88Bundle branch block (HP:0011710)2.17937469
89Type 2 muscle fiber atrophy (HP:0003554)2.17199546
90Emotional lability (HP:0000712)2.16215143
91Muscle stiffness (HP:0003552)2.15778692
92Right ventricular cardiomyopathy (HP:0011663)2.14541144
93Rectal fistula (HP:0100590)2.14460821
94Rectovaginal fistula (HP:0000143)2.14460821
95Left ventricular hypertrophy (HP:0001712)2.14073027
96Cerebral hemorrhage (HP:0001342)2.13677766
97Neoplasm of head and neck (HP:0012288)2.12706784
98Esophageal neoplasm (HP:0100751)2.12706784
99Exertional dyspnea (HP:0002875)2.12064669
100Ventricular arrhythmia (HP:0004308)2.11531062
101Calcaneovalgus deformity (HP:0001848)2.11311363
102Methylmalonic acidemia (HP:0002912)2.10701405
103Microretrognathia (HP:0000308)2.08805764
104Abnormality of the left ventricular outflow tract (HP:0011103)2.08504200
105Subaortic stenosis (HP:0001682)2.08504200
106Rib fusion (HP:0000902)2.07892746
107Absent thumb (HP:0009777)2.07516742
108Pallor (HP:0000980)2.06413556
109Ventricular fibrillation (HP:0001663)2.03951407
110Amniotic constriction ring (HP:0009775)2.03939253
111Abnormality of placental membranes (HP:0011409)2.03939253
112Abnormality of renal resorption (HP:0011038)2.01790984
113Metabolic acidosis (HP:0001942)2.01696068
114Heart block (HP:0012722)2.01334765
115Multiple enchondromatosis (HP:0005701)2.01290891
116Vaginal fistula (HP:0004320)1.98697835
117Asymmetric septal hypertrophy (HP:0001670)1.94844266
118Myokymia (HP:0002411)1.92440272
119Deformed tarsal bones (HP:0008119)1.92288894
120Aplastic anemia (HP:0001915)1.91946574
121Neck muscle weakness (HP:0000467)1.91481155
122Abnormal EKG (HP:0003115)1.90907121
123Birth length less than 3rd percentile (HP:0003561)1.88935646
124Cerebral hypomyelination (HP:0006808)1.86867545
125Proximal tubulopathy (HP:0000114)1.85773310
126Hyperammonemia (HP:0001987)1.85560809
127Focal motor seizures (HP:0011153)1.84976058
128Distal arthrogryposis (HP:0005684)1.84821176
129Abnormal atrioventricular conduction (HP:0005150)1.84074007
130Progressive external ophthalmoplegia (HP:0000590)1.81147365
131Gliosis (HP:0002171)1.80465387
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80308706
133Abnormal protein N-linked glycosylation (HP:0012347)1.80308706
134Abnormal protein glycosylation (HP:0012346)1.80308706
135Abnormal glycosylation (HP:0012345)1.80308706
136Oligomenorrhea (HP:0000876)1.79807780
137Atrioventricular block (HP:0001678)1.78759072
138Hyperglycinuria (HP:0003108)1.78017249
139Hyperphosphaturia (HP:0003109)1.77928011
140Hypoplastic heart (HP:0001961)1.77555176
141Absent phalangeal crease (HP:0006109)1.76438740
142Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76110709
143Bulbar palsy (HP:0001283)1.74497787
144Progressive microcephaly (HP:0000253)1.69899132
145Centrally nucleated skeletal muscle fibers (HP:0003687)1.69417668
146Hyperglycinemia (HP:0002154)1.66764493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.16288608
2VRK23.88628431
3NME13.36916397
4PDK33.24981207
5PDK43.24981207
6TESK23.17539752
7BUB13.15255249
8OBSCN3.03451844
9BCKDK3.03267889
10PHKG12.85356840
11PHKG22.85356840
12MUSK2.77524359
13TTN2.65429731
14LMTK22.50451104
15MAP3K122.45080842
16GRK72.33328870
17TLK12.27260712
18NME22.24857900
19PDK22.22764497
20STK392.21032691
21WNK42.16605708
22CASK2.08105057
23PBK2.06262356
24PIK3CA2.03709435
25PINK11.96462059
26TESK11.84973564
27ARAF1.67569080
28OXSR11.67351206
29CDC71.67055118
30STK161.66108916
31SRPK11.63084851
32CAMK2D1.58023377
33GRK51.53747264
34MAP2K71.47888937
35VRK11.42209592
36LIMK11.40009212
37DYRK21.33969213
38AURKA1.28982741
39DAPK31.19867646
40NEK11.18406728
41MAP3K41.17854682
42CAMK2A1.17161448
43LRRK21.11692068
44SCYL21.11172002
45CDK191.09169330
46CAMK2G1.08856700
47PKN11.08837114
48ILK1.08715586
49MST1R1.07865357
50CCNB11.05467162
51TIE11.03201692
52MAPK121.02209055
53MST40.99382432
54CAMK2B0.98472483
55STK240.97284263
56PLK10.95718854
57EPHA40.94030410
58PNCK0.91345965
59MAP2K40.90619531
60MAPKAPK50.89624685
61ADRBK20.87106346
62AKT20.85570383
63MAPK150.84613823
64PAK30.84351668
65CSNK1G30.83367687
66ROCK20.83194975
67PRKCE0.81905497
68AURKB0.79946783
69PTK2B0.76469811
70RPS6KB20.76215924
71ADRBK10.75612093
72RPS6KA50.75253140
73TTK0.75013914
74BRSK10.74800636
75PRKACA0.74034089
76TRIM280.73054252
77PLK20.70037825
78ATR0.68960381
79CHEK20.68842887
80CSNK2A20.67876182
81DYRK30.67038672
82PAK10.67012002
83ROCK10.66534574
84BRAF0.63115284
85CSNK2A10.62815412
86CDK11A0.62771832
87ABL20.62491152
88TNIK0.61168634
89KDR0.59077261
90WNK30.58931075
91PRKD10.58844863
92CDK150.58096457
93UHMK10.56972337
94DMPK0.55634281
95CDK140.54727627
96BCR0.54657033
97PRKCG0.54607757
98STK40.54259269
99CDK180.54096725
100WNK10.53609014
101PRKCI0.52112312
102MINK10.50515026
103MARK10.50026691
104CAMK10.49557741
105PRKACB0.49552011
106MAP4K20.49200859
107CSNK1G20.47597622
108PAK40.46134363
109NUAK10.46108862
110STK38L0.45290270
111CSNK1G10.45092341
112BMPR1B0.44424487
113NTRK30.43085101
114PLK40.43017605
115PRKACG0.42205469
116EIF2AK30.42105687
117BMPR20.41078128
118MAP2K10.40946858
119EIF2AK10.40806122
120DYRK1B0.40569822
121CSNK1A1L0.40430149
122MAPK130.39243405
123SGK4940.39101540
124SGK2230.39101540
125PLK30.39035125
126CDK70.38663971
127INSRR0.38032334
128CDK80.37640975
129RPS6KC10.35412090
130RPS6KL10.35412090
131EEF2K0.35267519
132CHEK10.35197338
133CDC42BPA0.34045543
134PDPK10.33722250
135MAPK40.33503296
136CDK50.33326918
137TAOK20.33225208
138PIK3CG0.32934587
139ZAK0.32335403
140CSNK1E0.31944975
141DAPK10.31535555
142MAPKAPK30.31305299
143PRKCA0.30657768
144PRKAA20.29209129
145MAP2K60.28984132
146PRKG10.28975484
147MAP3K80.28741225
148SMG10.28668202
149GRK60.28615849
150MAP3K110.28203346
151PRKCQ0.28199068
152PIM20.27446989
153PRKAA10.27360311
154CAMK40.26973688
155GRK10.26940739
156TRIB30.24675882
157CDK20.23530991
158PRKD30.23431394

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.81184980
2Parkinsons disease_Homo sapiens_hsa050125.14210920
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.23414598
4Alzheimers disease_Homo sapiens_hsa050103.85174461
5Huntingtons disease_Homo sapiens_hsa050163.45487892
6Cardiac muscle contraction_Homo sapiens_hsa042603.43754924
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.25530309
8Propanoate metabolism_Homo sapiens_hsa006402.70057260
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.69814699
10DNA replication_Homo sapiens_hsa030302.59103333
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19530719
12Pyruvate metabolism_Homo sapiens_hsa006202.12769609
13Fatty acid elongation_Homo sapiens_hsa000622.07303978
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06556134
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01100975
16Base excision repair_Homo sapiens_hsa034101.99012369
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91960526
18Mismatch repair_Homo sapiens_hsa034301.87604335
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87077418
20Carbon metabolism_Homo sapiens_hsa012001.86826736
21Fatty acid degradation_Homo sapiens_hsa000711.80132447
22Proteasome_Homo sapiens_hsa030501.74779485
23Butanoate metabolism_Homo sapiens_hsa006501.72371851
24Ribosome_Homo sapiens_hsa030101.65708494
25Homologous recombination_Homo sapiens_hsa034401.64771871
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62289195
27Collecting duct acid secretion_Homo sapiens_hsa049661.52877397
28Fatty acid metabolism_Homo sapiens_hsa012121.51369053
29Spliceosome_Homo sapiens_hsa030401.45899449
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41071287
31Sulfur metabolism_Homo sapiens_hsa009201.37721282
32Nucleotide excision repair_Homo sapiens_hsa034201.34888787
33One carbon pool by folate_Homo sapiens_hsa006701.31074367
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27380883
35Dilated cardiomyopathy_Homo sapiens_hsa054141.15302921
36Phenylalanine metabolism_Homo sapiens_hsa003601.13995190
37Fanconi anemia pathway_Homo sapiens_hsa034601.13068614
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12048008
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10620654
40RNA transport_Homo sapiens_hsa030131.10426376
41Peroxisome_Homo sapiens_hsa041461.09038512
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01899970
43Protein export_Homo sapiens_hsa030600.95106583
44Tyrosine metabolism_Homo sapiens_hsa003500.93134906
45beta-Alanine metabolism_Homo sapiens_hsa004100.92397963
46Tryptophan metabolism_Homo sapiens_hsa003800.91991385
47RNA degradation_Homo sapiens_hsa030180.89862710
48* Metabolic pathways_Homo sapiens_hsa011000.85855051
49Biosynthesis of amino acids_Homo sapiens_hsa012300.85460834
50PPAR signaling pathway_Homo sapiens_hsa033200.83291236
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79996390
52Arginine and proline metabolism_Homo sapiens_hsa003300.78359433
53Vibrio cholerae infection_Homo sapiens_hsa051100.77972845
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76072047
55Synaptic vesicle cycle_Homo sapiens_hsa047210.75472316
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75423185
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.75336445
58Nicotine addiction_Homo sapiens_hsa050330.71271302
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.70832605
60Arginine biosynthesis_Homo sapiens_hsa002200.66645593
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66536725
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64704448
63RNA polymerase_Homo sapiens_hsa030200.61639582
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61611910
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61438443
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61167749
67Basal transcription factors_Homo sapiens_hsa030220.60245813
68Glutathione metabolism_Homo sapiens_hsa004800.57254374
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56733485
70Histidine metabolism_Homo sapiens_hsa003400.55796680
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54375677
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.54145764
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51643705
74Starch and sucrose metabolism_Homo sapiens_hsa005000.51306475
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51201902
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50553182
77GABAergic synapse_Homo sapiens_hsa047270.50372211
78Calcium signaling pathway_Homo sapiens_hsa040200.50170531
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49848134
80Fructose and mannose metabolism_Homo sapiens_hsa000510.48922696
81Chemical carcinogenesis_Homo sapiens_hsa052040.44456680
82Taste transduction_Homo sapiens_hsa047420.43455327
83Sulfur relay system_Homo sapiens_hsa041220.43234718
84Folate biosynthesis_Homo sapiens_hsa007900.41528038
85Cell cycle_Homo sapiens_hsa041100.40620321
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39158430
87Serotonergic synapse_Homo sapiens_hsa047260.35096466
88Fat digestion and absorption_Homo sapiens_hsa049750.33274774
89Circadian entrainment_Homo sapiens_hsa047130.33128043
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.32736724
91Morphine addiction_Homo sapiens_hsa050320.31295630
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30392939
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29882411
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29664770
95Linoleic acid metabolism_Homo sapiens_hsa005910.29316484
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29010959
97Glucagon signaling pathway_Homo sapiens_hsa049220.28575784
98Galactose metabolism_Homo sapiens_hsa000520.28093868
99Amphetamine addiction_Homo sapiens_hsa050310.27374669
100Pentose phosphate pathway_Homo sapiens_hsa000300.27139192
101Renin secretion_Homo sapiens_hsa049240.27081218
102Regulation of autophagy_Homo sapiens_hsa041400.26564802
103Arachidonic acid metabolism_Homo sapiens_hsa005900.26083203
104Non-homologous end-joining_Homo sapiens_hsa034500.25700556
105Purine metabolism_Homo sapiens_hsa002300.24659566
106mRNA surveillance pathway_Homo sapiens_hsa030150.22623807
107Salivary secretion_Homo sapiens_hsa049700.22497110
108Gastric acid secretion_Homo sapiens_hsa049710.22358248
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.21859146
110Glycerolipid metabolism_Homo sapiens_hsa005610.21442766
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21021249
112Olfactory transduction_Homo sapiens_hsa047400.20816042
113Dopaminergic synapse_Homo sapiens_hsa047280.20265114
114Systemic lupus erythematosus_Homo sapiens_hsa053220.20180262
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20033298
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19738769
117Rheumatoid arthritis_Homo sapiens_hsa053230.19670566
118Pyrimidine metabolism_Homo sapiens_hsa002400.19260032
119Nitrogen metabolism_Homo sapiens_hsa009100.18927066
120Glutamatergic synapse_Homo sapiens_hsa047240.18797953
121Phototransduction_Homo sapiens_hsa047440.18513432
122Insulin secretion_Homo sapiens_hsa049110.18024687
123Vitamin B6 metabolism_Homo sapiens_hsa007500.17039755
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16225626
125Bile secretion_Homo sapiens_hsa049760.15814540
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15068407
127Vitamin digestion and absorption_Homo sapiens_hsa049770.14954244
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14888584
129Alcoholism_Homo sapiens_hsa050340.14236445
130Oocyte meiosis_Homo sapiens_hsa041140.13823027
131Retinol metabolism_Homo sapiens_hsa008300.12246738
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11002970
133Selenocompound metabolism_Homo sapiens_hsa004500.10037394
134Steroid biosynthesis_Homo sapiens_hsa001000.09912281
135Epstein-Barr virus infection_Homo sapiens_hsa051690.08987165
136N-Glycan biosynthesis_Homo sapiens_hsa005100.08779455

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