NDUFB1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.81563244
2Arp2/3 complex-mediated actin nucleation (GO:0034314)6.53083862
3actin nucleation (GO:0045010)6.10870863
4sequestering of actin monomers (GO:0042989)5.81766829
5positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.72078159
6pyrimidine nucleoside catabolic process (GO:0046135)5.57713177
7regulation of activation of Janus kinase activity (GO:0010533)4.99910743
8response to pheromone (GO:0019236)4.73509979
9negative regulation of viral genome replication (GO:0045071)4.67854588
10GDP-mannose metabolic process (GO:0019673)4.64214870
11positive T cell selection (GO:0043368)4.48063450
12cytolysis (GO:0019835)4.21272603
13negative regulation of nitric-oxide synthase activity (GO:0051001)4.20190026
14pyrimidine-containing compound catabolic process (GO:0072529)4.15937096
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06192663
16negative regulation of oxidoreductase activity (GO:0051354)3.94947280
17negative regulation by host of viral transcription (GO:0043922)3.92915886
18metallo-sulfur cluster assembly (GO:0031163)3.89828927
19iron-sulfur cluster assembly (GO:0016226)3.89828927
20ribosomal small subunit assembly (GO:0000028)3.72829414
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72126026
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70502370
23positive thymic T cell selection (GO:0045059)3.70441221
24behavioral response to nicotine (GO:0035095)3.60951488
25positive regulation of monocyte chemotaxis (GO:0090026)3.60361663
26negative T cell selection (GO:0043383)3.54549740
27negative regulation of monooxygenase activity (GO:0032769)3.54466706
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51966496
29ATP synthesis coupled proton transport (GO:0015986)3.51966496
30terpenoid biosynthetic process (GO:0016114)3.49789013
31adaptation of signaling pathway (GO:0023058)3.49722315
32positive regulation of calcium-mediated signaling (GO:0050850)3.49478507
33regulation of T cell chemotaxis (GO:0010819)3.42746439
34positive regulation of T cell chemotaxis (GO:0010820)3.42746439
35production of molecular mediator involved in inflammatory response (GO:0002532)3.41918656
36cell wall macromolecule metabolic process (GO:0044036)3.39974764
37negative regulation of stress fiber assembly (GO:0051497)3.39337832
38positive regulation of chemokine secretion (GO:0090197)3.35256367
39negative regulation of mast cell activation (GO:0033004)3.34934272
40respiratory electron transport chain (GO:0022904)3.31343415
41positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.27501671
42regulation of regulatory T cell differentiation (GO:0045589)3.27155751
43electron transport chain (GO:0022900)3.23698250
44regulation of viral genome replication (GO:0045069)3.20856223
45pyrimidine ribonucleoside metabolic process (GO:0046131)3.19060500
46positive regulation of natural killer cell mediated immunity (GO:0002717)3.16319381
47DNA demethylation (GO:0080111)3.14448310
48protein neddylation (GO:0045116)3.09367125
49macrophage chemotaxis (GO:0048246)3.08417846
50pyrimidine nucleotide catabolic process (GO:0006244)3.08322828
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.08156067
52T cell migration (GO:0072678)3.06078576
53eosinophil chemotaxis (GO:0048245)3.05973403
54platelet dense granule organization (GO:0060155)2.99606944
55positive regulation of interleukin-8 secretion (GO:2000484)2.94105707
56regulation of B cell receptor signaling pathway (GO:0050855)2.91645391
57regulation of natural killer cell mediated immunity (GO:0002715)2.91526148
58regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91526148
59positive regulation of megakaryocyte differentiation (GO:0045654)2.91354724
60transmission of nerve impulse (GO:0019226)2.89094421
61positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.88457427
62negative regulation of T cell apoptotic process (GO:0070233)2.85123253
63T cell selection (GO:0045058)2.84810237
64positive regulation of gamma-delta T cell activation (GO:0046645)2.82043288
65response to interferon-beta (GO:0035456)2.80854358
66regulation of chemokine secretion (GO:0090196)2.79820133
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.79770175
68positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.78831680
69positive regulation of T cell apoptotic process (GO:0070234)2.78758106
70eosinophil migration (GO:0072677)2.78121292
71negative regulation of actin filament bundle assembly (GO:0032232)2.75352053
72histone arginine methylation (GO:0034969)2.73148835
73glucosamine-containing compound catabolic process (GO:1901072)2.72256504
74thymic T cell selection (GO:0045061)2.70989516
75T cell receptor signaling pathway (GO:0050852)2.69775617
76positive regulation of B cell differentiation (GO:0045579)2.69332055
77regulation of T cell tolerance induction (GO:0002664)2.68559477
78ncRNA 3-end processing (GO:0043628)2.68269543
79DNA dealkylation (GO:0035510)2.67549492
80regulation of cellular amino acid metabolic process (GO:0006521)2.66617731
81regulation of T cell receptor signaling pathway (GO:0050856)2.65634678
82regulation of leukocyte mediated cytotoxicity (GO:0001910)2.64318020
83regulation of lymphocyte chemotaxis (GO:1901623)2.63628602
84positive regulation of tolerance induction (GO:0002645)2.63038487
85negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.62946849
86dendritic cell migration (GO:0036336)2.61564482
87cellular response to interleukin-15 (GO:0071350)2.60213962
88pyrimidine nucleoside metabolic process (GO:0006213)2.60175193
89regulation of gamma-delta T cell differentiation (GO:0045586)2.59294185
90regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58238278
91negative regulation of calcium ion transport into cytosol (GO:0010523)2.56676161
92negative regulation of viral process (GO:0048525)2.56588728
93regulation of calcium-mediated signaling (GO:0050848)2.56210879
94positive regulation of phosphatase activity (GO:0010922)2.55752599
95positive regulation of cAMP-mediated signaling (GO:0043950)2.54775874
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509112.7113726
97cytidine metabolic process (GO:0046087)11.1308168
98cytidine catabolic process (GO:0006216)11.1308168
99cytidine deamination (GO:0009972)11.1308168
100DNA deamination (GO:0045006)10.3980104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.48802230
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.66837261
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.95100390
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.24729889
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10242800
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.01357726
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78374731
8VDR_22108803_ChIP-Seq_LS180_Human2.71524682
9ZNF274_21170338_ChIP-Seq_K562_Hela2.50493340
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22228649
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09740813
12ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99409167
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73119533
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68327821
15GABP_17652178_ChIP-ChIP_JURKAT_Human1.68044882
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65968889
17BCAT_22108803_ChIP-Seq_LS180_Human1.64392565
18NCOR_22424771_ChIP-Seq_293T_Human1.60481036
19TP53_22573176_ChIP-Seq_HFKS_Human1.59619757
20NANOG_20526341_ChIP-Seq_ESCs_Human1.57921494
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57195340
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57139292
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52631791
24AR_20517297_ChIP-Seq_VCAP_Human1.52466194
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51056281
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.49673668
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49057914
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39910666
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36298421
30TAF2_19829295_ChIP-Seq_ESCs_Human1.34833417
31GATA3_26560356_Chip-Seq_TH2_Human1.33727904
32PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32607327
33MYB_26560356_Chip-Seq_TH2_Human1.31603486
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.30907369
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.30904419
36NANOG_19829295_ChIP-Seq_ESCs_Human1.29139890
37SOX2_19829295_ChIP-Seq_ESCs_Human1.29139890
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.28007687
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25748649
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.25219316
41HTT_18923047_ChIP-ChIP_STHdh_Human1.24585121
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23809072
43CIITA_25753668_ChIP-Seq_RAJI_Human1.23420014
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.23060479
45EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.23048043
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23013265
47GBX2_23144817_ChIP-Seq_PC3_Human1.22316415
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22264231
49RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20093380
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19893740
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19752721
52PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18883177
53ERG_20517297_ChIP-Seq_VCAP_Human1.18141417
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17581900
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16960291
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16107723
57CBP_20019798_ChIP-Seq_JUKART_Human1.16107723
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14942550
59RUNX_20019798_ChIP-Seq_JUKART_Human1.14600951
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13419475
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11801857
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11696607
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11629707
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.11407152
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.11231676
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10178768
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.09753989
68GATA3_27048872_Chip-Seq_THYMUS_Human1.09067851
69ERA_21632823_ChIP-Seq_H3396_Human1.08851999
70MYC_18940864_ChIP-ChIP_HL60_Human1.08279162
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07966379
72GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05884393
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05760010
74VDR_23849224_ChIP-Seq_CD4+_Human1.04792879
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04233466
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04042797
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03772432
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03628796
79MYC_19829295_ChIP-Seq_ESCs_Human1.03392536
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02807762
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.02807762
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.01192487
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01154782
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00389671
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00084443
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00075830
87REST_21632747_ChIP-Seq_MESCs_Mouse0.99377490
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99041733
89EZH2_27294783_Chip-Seq_ESCs_Mouse0.96344746
90MYB_26560356_Chip-Seq_TH1_Human0.96250634
91JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96039933
92BCL6_27268052_Chip-Seq_Bcells_Human0.95223332
93P53_21459846_ChIP-Seq_SAOS-2_Human0.95062601
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94230367
95RAC3_21632823_ChIP-Seq_H3396_Human0.94078334
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93730558
97IGF1R_20145208_ChIP-Seq_DFB_Human0.93289496
98UTX_26944678_Chip-Seq_JUKART_Human0.93271597
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92780218
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91675413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.79196986
2MP0003806_abnormal_nucleotide_metabolis2.70204398
3MP0002166_altered_tumor_susceptibility2.65816844
4MP0004147_increased_porphyrin_level2.58573301
5MP0000372_irregular_coat_pigmentation2.53392866
6MP0009379_abnormal_foot_pigmentation2.50945258
7MP0009785_altered_susceptibility_to2.39072766
8MP0003880_abnormal_central_pattern2.34646779
9MP0009333_abnormal_splenocyte_physiolog2.32080981
10MP0003763_abnormal_thymus_physiology2.31020146
11MP0005645_abnormal_hypothalamus_physiol2.20368041
12MP0008995_early_reproductive_senescence2.20311598
13MP0002006_tumorigenesis2.18477765
14MP0002254_reproductive_system_inflammat1.99113646
15MP0008057_abnormal_DNA_replication1.96605518
16MP0000685_abnormal_immune_system1.91997957
17MP0006276_abnormal_autonomic_nervous1.89282260
18MP0001348_abnormal_lacrimal_gland1.88746570
19MP0001919_abnormal_reproductive_system1.88295603
20MP0005257_abnormal_intraocular_pressure1.86462077
21MP0001873_stomach_inflammation1.84659246
22MP0004885_abnormal_endolymph1.83597243
23MP0003866_abnormal_defecation1.80454876
24MP0003646_muscle_fatigue1.78926647
25MP0002638_abnormal_pupillary_reflex1.78306612
26MP0003136_yellow_coat_color1.72694712
27MP0005084_abnormal_gallbladder_morpholo1.64394463
28MP0001835_abnormal_antigen_presentation1.63676515
29MP0008872_abnormal_physiological_respon1.62950749
30MP0005025_abnormal_response_to1.61508759
31MP0005551_abnormal_eye_electrophysiolog1.57938274
32MP0005423_abnormal_somatic_nervous1.53601878
33MP0006072_abnormal_retinal_apoptosis1.52648500
34MP0002095_abnormal_skin_pigmentation1.52627985
35MP0003786_premature_aging1.50940218
36MP0005387_immune_system_phenotype1.44144539
37MP0001790_abnormal_immune_system1.44144539
38MP0008877_abnormal_DNA_methylation1.43680611
39MP0005253_abnormal_eye_physiology1.37461804
40MP0001800_abnormal_humoral_immune1.36640497
41MP0002163_abnormal_gland_morphology1.35427713
42MP0002420_abnormal_adaptive_immunity1.33769744
43MP0002138_abnormal_hepatobiliary_system1.33574252
44MP0002723_abnormal_immune_serum1.33049647
45MP0005000_abnormal_immune_tolerance1.32867395
46MP0006082_CNS_inflammation1.30565990
47MP0001819_abnormal_immune_cell1.26897738
48MP0001968_abnormal_touch/_nociception1.24584155
49MP0003878_abnormal_ear_physiology1.22315992
50MP0005377_hearing/vestibular/ear_phenot1.22315992
51MP0005389_reproductive_system_phenotype1.18511773
52MP0002102_abnormal_ear_morphology1.17160003
53MP0000604_amyloidosis1.15666719
54MP0002148_abnormal_hypersensitivity_rea1.13292036
55MP0001905_abnormal_dopamine_level1.11738541
56MP0004742_abnormal_vestibular_system1.10846359
57MP0003011_delayed_dark_adaptation1.10588736
58MP0001970_abnormal_pain_threshold1.08784802
59MP0002876_abnormal_thyroid_physiology1.08208734
60MP0009764_decreased_sensitivity_to1.07534511
61MP0001529_abnormal_vocalization1.03597647
62MP0002733_abnormal_thermal_nociception1.03489076
63MP0002405_respiratory_system_inflammati1.01884784
64MP0009745_abnormal_behavioral_response1.01414908
65MP0001663_abnormal_digestive_system0.99883514
66MP0003448_altered_tumor_morphology0.99830556
67MP0003191_abnormal_cellular_cholesterol0.99517461
68MP0010155_abnormal_intestine_physiology0.99019204
69MP0002277_abnormal_respiratory_mucosa0.95698615
70MP0003436_decreased_susceptibility_to0.95600231
71MP0002736_abnormal_nociception_after0.94352349
72MP0000716_abnormal_immune_system0.94160571
73MP0005166_decreased_susceptibility_to0.92145076
74MP0002398_abnormal_bone_marrow0.87612020
75MP0001845_abnormal_inflammatory_respons0.87422172
76MP0003119_abnormal_digestive_system0.86632263
77MP0004130_abnormal_muscle_cell0.84588601
78MP0003137_abnormal_impulse_conducting0.81144853
79MP0004133_heterotaxia0.80582191
80MP0005075_abnormal_melanosome_morpholog0.79464472
81MP0005195_abnormal_posterior_eye0.78403405
82MP0001485_abnormal_pinna_reflex0.77936691
83MP0003329_amyloid_beta_deposits0.76780830
84MP0000749_muscle_degeneration0.76024016
85MP0005647_abnormal_sex_gland0.75858973
86MP0000703_abnormal_thymus_morphology0.75770645
87MP0001486_abnormal_startle_reflex0.73543816
88MP0002452_abnormal_antigen_presenting0.72422310
89MP0001440_abnormal_grooming_behavior0.71956542
90MP0002184_abnormal_innervation0.70981553
91MP0008007_abnormal_cellular_replicative0.70845575
92MP0002019_abnormal_tumor_incidence0.70745941
93MP0005174_abnormal_tail_pigmentation0.70638432
94MP0005381_digestive/alimentary_phenotyp0.70468500
95MP0002909_abnormal_adrenal_gland0.69050216
96MP0005266_abnormal_metabolism0.68981367
97MP0005448_abnormal_energy_balance0.68920377
98MP0001963_abnormal_hearing_physiology0.68361123
99MP0002693_abnormal_pancreas_physiology0.67696605
100MP0009763_increased_sensitivity_to0.67686142

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.01963024
2T lymphocytopenia (HP:0005403)4.01894871
3Acute necrotizing encephalopathy (HP:0006965)4.01626693
4Abnormality of T cell number (HP:0011839)3.93558750
5Hypoproteinemia (HP:0003075)3.72231871
6Abnormal mitochondria in muscle tissue (HP:0008316)3.65586270
7Severe visual impairment (HP:0001141)3.41014282
8Progressive macrocephaly (HP:0004481)3.35750495
9Increased CSF lactate (HP:0002490)3.34506607
10Pancreatic cysts (HP:0001737)3.25129535
11Congenital stationary night blindness (HP:0007642)3.24137519
12IgG deficiency (HP:0004315)3.19445932
13Hypoalbuminemia (HP:0003073)3.18660989
14Abnormal albumin level (HP:0012116)3.18660989
15Acute encephalopathy (HP:0006846)3.13263139
16Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.06672651
17Elevated erythrocyte sedimentation rate (HP:0003565)3.01577342
18Cerebral edema (HP:0002181)2.89978692
19Increased IgM level (HP:0003496)2.87071141
20Radial bowing (HP:0002986)2.83648080
21Abnormality of the phalanges of the 5th finger (HP:0004213)2.80753569
22Symphalangism affecting the phalanges of the hand (HP:0009773)2.79381354
23Hepatocellular necrosis (HP:0001404)2.77452340
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.74256268
25Agitation (HP:0000713)2.70404746
26Alacrima (HP:0000522)2.68316584
27Increased hepatocellular lipid droplets (HP:0006565)2.62408919
28Aplasia/Hypoplasia of the spleen (HP:0010451)2.62191123
29Renal Fanconi syndrome (HP:0001994)2.61058890
30Attenuation of retinal blood vessels (HP:0007843)2.59413504
31Polydipsia (HP:0001959)2.58450200
32Abnormal drinking behavior (HP:0030082)2.58450200
33Abnormal rod and cone electroretinograms (HP:0008323)2.56302426
34Orthostatic hypotension (HP:0001278)2.56063525
35Optic disc pallor (HP:0000543)2.53731899
36Fibular aplasia (HP:0002990)2.53116064
37Asplenia (HP:0001746)2.52429808
38Genetic anticipation (HP:0003743)2.50403398
39Pancreatic fibrosis (HP:0100732)2.49837389
40Lipid accumulation in hepatocytes (HP:0006561)2.49208994
41Hepatic necrosis (HP:0002605)2.48236713
42Dysautonomia (HP:0002459)2.43437025
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43139125
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43139125
45True hermaphroditism (HP:0010459)2.40484055
46Abnormality of eosinophils (HP:0001879)2.32964456
47Aplastic anemia (HP:0001915)2.32158866
48Thyroiditis (HP:0100646)2.31468406
49Increased intramyocellular lipid droplets (HP:0012240)2.30924769
50Type I transferrin isoform profile (HP:0003642)2.29703280
51Severe combined immunodeficiency (HP:0004430)2.27405019
52Acute hepatic failure (HP:0006554)2.27355209
53Arthropathy (HP:0003040)2.23307464
54Abnormality of midbrain morphology (HP:0002418)2.22760438
55Molar tooth sign on MRI (HP:0002419)2.22760438
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14153045
57Stomatitis (HP:0010280)2.10124338
583-Methylglutaconic aciduria (HP:0003535)2.09806859
59Cellular immunodeficiency (HP:0005374)2.09033972
60Concave nail (HP:0001598)2.08941223
61Recurrent corneal erosions (HP:0000495)2.08932626
62Anomalous pulmonary venous return (HP:0010772)2.08040057
63Decreased lacrimation (HP:0000633)2.06613990
64Increased muscle lipid content (HP:0009058)2.06176937
65Abnormality of B cell number (HP:0010975)2.04454636
66Decreased circulating renin level (HP:0003351)2.03722187
67Reduced antithrombin III activity (HP:0001976)2.02764725
68Abnormality of T cells (HP:0002843)2.02064884
69Abnormality of the proximal phalanges of the hand (HP:0009834)2.02014792
70Hemiplegia (HP:0002301)1.98493068
71Congenital hepatic fibrosis (HP:0002612)1.96760060
72Abolished electroretinogram (ERG) (HP:0000550)1.96758422
73Nephronophthisis (HP:0000090)1.96393734
74Medial flaring of the eyebrow (HP:0010747)1.92647826
75Progressive cerebellar ataxia (HP:0002073)1.89396132
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88378144
77Eosinophilia (HP:0001880)1.86788346
78Leukodystrophy (HP:0002415)1.86368017
79Autoimmune hemolytic anemia (HP:0001890)1.84581373
80Exertional dyspnea (HP:0002875)1.84042471
81B lymphocytopenia (HP:0010976)1.82811932
82Leukocytosis (HP:0001974)1.82736290
83Pancytopenia (HP:0001876)1.79125931
84Abnormality of the pulmonary veins (HP:0011718)1.78096807
85Intestinal atresia (HP:0011100)1.77585570
86Amyotrophic lateral sclerosis (HP:0007354)1.76478755
87Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76355241
88Increased serum lactate (HP:0002151)1.75692595
89Amblyopia (HP:0000646)1.75478694
90Polyuria (HP:0000103)1.74602823
91Parakeratosis (HP:0001036)1.73305572
92Abnormality of the prostate (HP:0008775)1.73094322
93Carpal bone hypoplasia (HP:0001498)1.73010729
94Hyponatremia (HP:0002902)1.72697491
95Absent/shortened dynein arms (HP:0200106)1.72622876
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.72622876
97Aplasia/Hypoplasia of the ulna (HP:0006495)1.71801829
98Generalized aminoaciduria (HP:0002909)1.69760321
99Decreased central vision (HP:0007663)1.69278656
100Lymphopenia (HP:0001888)1.69057957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.60187719
2TXK4.61163410
3BCKDK4.27294532
4TESK24.09316459
5MUSK3.60878303
6MAP3K122.87097416
7MAP4K22.59779742
8LIMK12.53157425
9TESK12.38274691
10MAP4K12.37848649
11TLK12.34919172
12ADRBK22.17321730
13ZAK2.07378094
14GRK72.06192456
15GRK62.04653621
16ITK1.81528758
17WNK41.64986017
18GRK11.64897744
19VRK21.61844523
20BTK1.61611057
21WNK31.59649821
22FRK1.48251386
23MAP3K111.35312713
24TIE11.28449252
25CAMKK21.27311497
26TAOK31.22334706
27STK391.21120113
28NME11.18598991
29ADRBK11.18026925
30SYK1.15007739
31VRK11.10480435
32MAPK131.07629252
33TEC1.05289771
34DYRK21.03770892
35PRKCQ1.00340191
36CAMKK10.96306293
37LMTK20.93489904
38SCYL20.90851801
39MST40.89919857
40MYLK0.89381297
41LCK0.85863781
42CSK0.76267396
43MATK0.75612670
44BMPR1B0.71515950
45INSRR0.65571619
46MAPKAPK30.63024976
47CHEK20.62381575
48MAP3K90.62014450
49PASK0.56872408
50LYN0.54873484
51AURKA0.54549196
52RPS6KA50.53274053
53PRKD30.53123199
54OBSCN0.52322883
55STK160.52014883
56PRKCH0.51459478
57IKBKB0.50564349
58PLK20.49877450
59ATR0.49152842
60TYRO30.48902724
61CSNK1G30.48393323
62PRKACA0.47269737
63FYN0.46377469
64PKN10.45942786
65PAK30.45081741
66HCK0.44839247
67PIK3CG0.44590609
68BUB10.42345793
69SRPK10.42063842
70ROCK10.41429161
71CSNK1G20.39384323
72ACVR1B0.39129295
73ERBB20.38879397
74PINK10.38869415
75NUAK10.38744763
76BRSK20.38160393
77PDK20.37831897
78NTRK10.37278352
79CAMK2A0.37252815
80PRKCG0.36532975
81NTRK20.34939179
82DAPK10.33752215
83PRKCA0.32835313
84ABL20.32517552
85JAK30.31879901
86CSNK1A1L0.31729338
87CLK10.29907059
88CAMK10.29455231
89IGF1R0.27892389
90PIM10.27849184
91DAPK30.27741697
92CSNK2A20.27592954
93CSF1R0.27567878
94EPHA40.26471852
95CSNK1G10.25456584
96MAPKAPK20.24322078
97PRKCE0.24277962
98FGR0.23725177
99PRKCB0.22775397
100CSNK2A10.22147245

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.16283618
2Oxidative phosphorylation_Homo sapiens_hsa001903.94257137
3Proteasome_Homo sapiens_hsa030503.79578638
4Parkinsons disease_Homo sapiens_hsa050123.16498691
5RNA polymerase_Homo sapiens_hsa030203.14279270
6Phototransduction_Homo sapiens_hsa047442.81168801
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.35906757
8Alzheimers disease_Homo sapiens_hsa050102.25350805
9Huntingtons disease_Homo sapiens_hsa050162.22291895
10Hematopoietic cell lineage_Homo sapiens_hsa046402.19335831
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.16024939
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14322492
13Graft-versus-host disease_Homo sapiens_hsa053322.14044623
14Protein export_Homo sapiens_hsa030602.08000086
15Ribosome_Homo sapiens_hsa030101.95533202
16Cardiac muscle contraction_Homo sapiens_hsa042601.93221883
17Autoimmune thyroid disease_Homo sapiens_hsa053201.89789477
18T cell receptor signaling pathway_Homo sapiens_hsa046601.81604743
19Antigen processing and presentation_Homo sapiens_hsa046121.79360615
20Nitrogen metabolism_Homo sapiens_hsa009101.71689526
21Regulation of autophagy_Homo sapiens_hsa041401.66659416
22Homologous recombination_Homo sapiens_hsa034401.66455221
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60158299
24Pyrimidine metabolism_Homo sapiens_hsa002401.50192876
25Allograft rejection_Homo sapiens_hsa053301.48086879
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41308932
27Shigellosis_Homo sapiens_hsa051311.37375446
28Nicotine addiction_Homo sapiens_hsa050331.31712428
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26664005
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19776763
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12167810
32Rheumatoid arthritis_Homo sapiens_hsa053231.11683436
33Purine metabolism_Homo sapiens_hsa002301.08686207
34Type I diabetes mellitus_Homo sapiens_hsa049401.07157502
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05941274
36Linoleic acid metabolism_Homo sapiens_hsa005911.05053574
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04690445
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02987279
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91867482
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91654639
41Fanconi anemia pathway_Homo sapiens_hsa034600.89505430
42Sulfur metabolism_Homo sapiens_hsa009200.88090327
43Salmonella infection_Homo sapiens_hsa051320.85323650
44Morphine addiction_Homo sapiens_hsa050320.82747722
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.80255647
46Steroid biosynthesis_Homo sapiens_hsa001000.79855054
47Butanoate metabolism_Homo sapiens_hsa006500.79570396
48GABAergic synapse_Homo sapiens_hsa047270.78042941
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.77343849
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.76268976
51RNA degradation_Homo sapiens_hsa030180.75425027
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75192688
53Systemic lupus erythematosus_Homo sapiens_hsa053220.75026581
54Collecting duct acid secretion_Homo sapiens_hsa049660.71878978
55Sulfur relay system_Homo sapiens_hsa041220.71025272
56Olfactory transduction_Homo sapiens_hsa047400.70428708
57Peroxisome_Homo sapiens_hsa041460.68083146
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61335363
59Viral myocarditis_Homo sapiens_hsa054160.61243982
60Ether lipid metabolism_Homo sapiens_hsa005650.59945640
61Propanoate metabolism_Homo sapiens_hsa006400.59928347
62Measles_Homo sapiens_hsa051620.59355830
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58279517
64Retinol metabolism_Homo sapiens_hsa008300.55421164
65Alcoholism_Homo sapiens_hsa050340.54568115
66Fat digestion and absorption_Homo sapiens_hsa049750.53636069
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49731914
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.49188190
69Glutamatergic synapse_Homo sapiens_hsa047240.47679711
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46690433
71Metabolic pathways_Homo sapiens_hsa011000.45675597
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44988322
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44329079
74Malaria_Homo sapiens_hsa051440.43722820
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43380863
76Circadian entrainment_Homo sapiens_hsa047130.41437481
77Chemical carcinogenesis_Homo sapiens_hsa052040.40909954
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40869022
79Chemokine signaling pathway_Homo sapiens_hsa040620.36639349
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35708974
81Salivary secretion_Homo sapiens_hsa049700.35385455
82Taste transduction_Homo sapiens_hsa047420.34095769
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34063559
84Ovarian steroidogenesis_Homo sapiens_hsa049130.33263593
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29304703
86DNA replication_Homo sapiens_hsa030300.27581651
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27541250
88Epstein-Barr virus infection_Homo sapiens_hsa051690.27417739
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26512189
90Fatty acid biosynthesis_Homo sapiens_hsa000610.26402084
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24848992
92Basal cell carcinoma_Homo sapiens_hsa052170.24217732
93Asthma_Homo sapiens_hsa053100.23682503
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23058450
95Basal transcription factors_Homo sapiens_hsa030220.22773934
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22660702
97Calcium signaling pathway_Homo sapiens_hsa040200.21832159
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.21752845
99Glycerolipid metabolism_Homo sapiens_hsa005610.21749195
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21283803

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