ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tyrosine phosphorylation of STAT protein (GO:0007260)	8.71371172
2	acrosome assembly (GO:0001675)	8.54032941
3	pyrimidine dimer repair (GO:0006290)	5.14416050
4	presynaptic membrane assembly (GO:0097105)	4.48974950
5	righting reflex (GO:0060013)	4.43128599
6	piRNA metabolic process (GO:0034587)	4.13443865
7	activated T cell proliferation (GO:0050798)	4.09244101
8	regulation of female receptivity (GO:0045924)	4.01892949
9	glycerophospholipid catabolic process (GO:0046475)	3.93905020
10	limb bud formation (GO:0060174)	3.85967424
11	cardiac right ventricle morphogenesis (GO:0003215)	3.80688654
12	intestinal cholesterol absorption (GO:0030299)	3.75351213
13	regulation of hippo signaling (GO:0035330)	3.70987407
14	sexual reproduction (GO:0019953)	3.70873840
15	regulation of timing of cell differentiation (GO:0048505)	3.60243354
16	regulation of sequestering of triglyceride (GO:0010889)	3.59572198
17	male meiosis (GO:0007140)	3.58107677
18	reflex (GO:0060004)	3.54522093
19	anatomical structure regression (GO:0060033)	3.51983175
20	protein-chromophore linkage (GO:0018298)	3.49688064
21	presynaptic membrane organization (GO:0097090)	3.49071181
22	negative regulation of circadian rhythm (GO:0042754)	3.42795544
23	regulation of development, heterochronic (GO:0040034)	3.41574876
24	lipid particle organization (GO:0034389)	3.41320008
25	kidney morphogenesis (GO:0060993)	3.30173216
26	DNA integration (GO:0015074)	3.29416576
27	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.25359461
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.25359461
29	female mating behavior (GO:0060180)	3.23505198
30	olfactory bulb development (GO:0021772)	3.23385199
31	positive regulation of cardiac muscle tissue growth (GO:0055023)	3.19941645
32	aldehyde catabolic process (GO:0046185)	3.19129101
33	poly(A)+ mRNA export from nucleus (GO:0016973)	3.17737793
34	lung secretory cell differentiation (GO:0061140)	3.15065779
35	binding of sperm to zona pellucida (GO:0007339)	3.07535783
36	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.07531568
37	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.05226072
38	positive regulation of cardiac muscle cell proliferation (GO:0060045)	2.99528917
39	positive regulation of muscle hypertrophy (GO:0014742)	2.98752590
40	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.98752590
41	regulation of meiosis I (GO:0060631)	2.96549009
42	startle response (GO:0001964)	2.92646779
43	gene silencing by RNA (GO:0031047)	2.92274852
44	DNA methylation involved in gamete generation (GO:0043046)	2.89829121
45	heart field specification (GO:0003128)	2.88412386
46	secondary heart field specification (GO:0003139)	2.88412386
47	negative regulation of digestive system process (GO:0060457)	2.87682822
48	sperm-egg recognition (GO:0035036)	2.86724782
49	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.86126153
50	parturition (GO:0007567)	2.85693315
51	positive regulation of heart growth (GO:0060421)	2.82813895
52	reproduction (GO:0000003)	2.80546170
53	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.79681631
54	behavioral response to nicotine (GO:0035095)	2.78809545
55	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.77616782
56	tongue development (GO:0043586)	2.76336810
57	behavioral response to ethanol (GO:0048149)	2.75828075
58	positive regulation of smooth muscle cell migration (GO:0014911)	2.75425428
59	interferon-gamma secretion (GO:0072643)	2.75166097
60	regulation of acrosome reaction (GO:0060046)	2.73581722
61	regulation of glucocorticoid secretion (GO:2000849)	2.72908200
62	regulation of cardiac muscle tissue growth (GO:0055021)	2.72239808
63	gamma-aminobutyric acid transport (GO:0015812)	2.71463175
64	negative regulation of neurological system process (GO:0031645)	2.70136961
65	auditory receptor cell differentiation (GO:0042491)	2.69991562
66	maintenance of protein location in nucleus (GO:0051457)	2.69555533
67	protein localization to cilium (GO:0061512)	2.69003067
68	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.68445224
69	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.67571098
70	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.67571098
71	kinetochore assembly (GO:0051382)	2.67296130
72	prostate gland growth (GO:0060736)	2.67195800
73	histone H3-K9 demethylation (GO:0033169)	2.66302930
74	epithelial cilium movement (GO:0003351)	2.66192480
75	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.65568947
76	regulation of female gonad development (GO:2000194)	2.65559650
77	lung epithelial cell differentiation (GO:0060487)	2.65505868
78	pericardium development (GO:0060039)	2.64234452
79	gonadal mesoderm development (GO:0007506)	2.63240755
80	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.62201772
81	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.61867412
82	multicellular organism reproduction (GO:0032504)	2.61430379
83	COPII vesicle coating (GO:0048208)	2.61329776
84	cornea development in camera-type eye (GO:0061303)	2.59418993
85	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	2.59386542
86	pyrimidine nucleobase catabolic process (GO:0006208)	2.58457999
87	positive regulation of cardiac muscle tissue development (GO:0055025)	2.57519202
88	synaptonemal complex assembly (GO:0007130)	2.56182475
89	meiotic cell cycle (GO:0051321)	2.55506565
90	retinal cone cell development (GO:0046549)	2.55484264
91	positive regulation of developmental pigmentation (GO:0048087)	2.55295056
92	regulation of corticosteroid hormone secretion (GO:2000846)	2.54463839
93	DNA damage induced protein phosphorylation (GO:0006975)	2.54320838
94	cerebral cortex radially oriented cell migration (GO:0021799)	2.52429306
95	lung cell differentiation (GO:0060479)	2.51184797
96	acrosome reaction (GO:0007340)	2.50205941
97	sequestering of extracellular ligand from receptor (GO:0035581)	2.49735119
98	lens development in camera-type eye (GO:0002088)	2.49715886
99	positive regulation of fatty acid transport (GO:2000193)	2.49182053
100	synaptonemal complex organization (GO:0070193)	2.44367454

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.69477737
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.64121987
3	GBX2_23144817_ChIP-Seq_PC3_Human	4.05691268
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.83581501
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.65060076
6	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.80445973
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.65461900
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59551844
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.56601959
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.52465899
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.38394566
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.30427467
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.26902663
14	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.24938046
15	FUS_26573619_Chip-Seq_HEK293_Human	2.03305219
16	IRF1_19129219_ChIP-ChIP_H3396_Human	2.03085247
17	P300_19829295_ChIP-Seq_ESCs_Human	1.98260603
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.95058830
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.92304660
20	EWS_26573619_Chip-Seq_HEK293_Human	1.92211391
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.91644424
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.88253365
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87109653
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.85074085
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.77385682
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.76179829
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72515407
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.67542528
29	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.67510260
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.64108301
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61554375
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.57661909
33	VDR_22108803_ChIP-Seq_LS180_Human	1.56369887
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55018853
35	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.54646763
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.53311440
37	AR_21572438_ChIP-Seq_LNCaP_Human	1.51510166
38	STAT3_23295773_ChIP-Seq_U87_Human	1.50999566
39	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47863752
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46122640
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.45853060
42	TCF4_23295773_ChIP-Seq_U87_Human	1.45057532
43	AR_25329375_ChIP-Seq_VCAP_Human	1.44219910
44	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.42071422
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39588256
46	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.39211832
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35248093
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.35248093
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.35135305
50	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32859205
51	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31533805
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30905104
53	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.28556909
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.28117822
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.23931369
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23750012
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22695612
58	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22316716
59	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.20913827
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18056354
61	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17198300
62	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.16887480
63	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16374640
64	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.16136327
65	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.15696806
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15371085
67	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13414351
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13414351
69	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13291398
70	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.13282210
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11978422
72	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.11108214
73	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10538027
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09753838
75	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.09662864
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09647815
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.08600826
78	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07829293
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07117257
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.06636225
81	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05745316
82	KDM2B_26808549_Chip-Seq_REH_Human	1.05320800
83	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04023889
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03480790
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02632323
86	CDX2_22108803_ChIP-Seq_LS180_Human	1.02029405
87	JUN_21703547_ChIP-Seq_K562_Human	1.01689550
88	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.00918684
89	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.00263601
90	TP53_22573176_ChIP-Seq_HFKS_Human	0.99953633
91	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.99896615
92	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.99872204
93	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.99872204
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.99749036
95	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.99681010
96	TP53_16413492_ChIP-PET_HCT116_Human	0.98856409
97	TP53_18474530_ChIP-ChIP_U2OS_Human	0.97329406
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97297955
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96392867
100	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.95794532

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.68021130
2	MP0002139_abnormal_hepatobiliary_system	3.42542078
3	MP0003880_abnormal_central_pattern	3.14165081
4	MP0002638_abnormal_pupillary_reflex	2.88090276
5	MP0002876_abnormal_thyroid_physiology	2.79060987
6	MP0009780_abnormal_chondrocyte_physiolo	2.64355144
7	MP0008995_early_reproductive_senescence	2.57551639
8	MP0005646_abnormal_pituitary_gland	2.55939396
9	MP0006292_abnormal_olfactory_placode	2.39052329
10	MP0005503_abnormal_tendon_morphology	2.16820928
11	MP0001666_abnormal_nutrient_absorption	2.15138247
12	MP0008789_abnormal_olfactory_epithelium	2.12205931
13	MP0005275_abnormal_skin_tensile	2.09213147
14	MP0003938_abnormal_ear_development	2.02430354
15	MP0002234_abnormal_pharynx_morphology	1.84798197
16	MP0002108_abnormal_muscle_morphology	1.84496963
17	MP0004142_abnormal_muscle_tone	1.83470797
18	MP0003121_genomic_imprinting	1.79244235
19	MP0003718_maternal_effect	1.73553262
20	MP0005075_abnormal_melanosome_morpholog	1.71853513
21	MP0002160_abnormal_reproductive_system	1.69393363
22	MP0000678_abnormal_parathyroid_gland	1.67129436
23	MP0005257_abnormal_intraocular_pressure	1.65713917
24	MP0003119_abnormal_digestive_system	1.64113960
25	MP0000013_abnormal_adipose_tissue	1.63081241
26	MP0009384_cardiac_valve_regurgitation	1.62139583
27	MP0000049_abnormal_middle_ear	1.62113979
28	MP0005394_taste/olfaction_phenotype	1.61815750
29	MP0005499_abnormal_olfactory_system	1.61815750
30	MP0003122_maternal_imprinting	1.61276311
31	MP0004133_heterotaxia	1.59762711
32	MP0002272_abnormal_nervous_system	1.59612487
33	MP0002938_white_spotting	1.57975424
34	MP0008438_abnormal_cutaneous_collagen	1.57635932
35	MP0001502_abnormal_circadian_rhythm	1.55130694
36	MP0005085_abnormal_gallbladder_physiolo	1.54740912
37	MP0002233_abnormal_nose_morphology	1.54106531
38	MP0000569_abnormal_digit_pigmentation	1.53693547
39	MP0003879_abnormal_hair_cell	1.52970647
40	MP0003786_premature_aging	1.50989632
41	MP0000372_irregular_coat_pigmentation	1.50110781
42	MP0000778_abnormal_nervous_system	1.45490952
43	MP0003890_abnormal_embryonic-extraembry	1.44844023
44	MP0005551_abnormal_eye_electrophysiolog	1.42133661
45	MP0003646_muscle_fatigue	1.41602146
46	MP0002210_abnormal_sex_determination	1.38049083
47	MP0001929_abnormal_gametogenesis	1.37682335
48	MP0001542_abnormal_bone_strength	1.36781571
49	MP0000631_abnormal_neuroendocrine_gland	1.36341648
50	MP0000653_abnormal_sex_gland	1.35892673
51	MP0002282_abnormal_trachea_morphology	1.34668740
52	MP0009046_muscle_twitch	1.33494045
53	MP0002751_abnormal_autonomic_nervous	1.26484279
54	MP0005423_abnormal_somatic_nervous	1.22911512
55	MP0009250_abnormal_appendicular_skeleto	1.20980885
56	MP0003755_abnormal_palate_morphology	1.19439846
57	MP0005171_absent_coat_pigmentation	1.18840168
58	MP0001145_abnormal_male_reproductive	1.18330933
59	MP0006276_abnormal_autonomic_nervous	1.17125515
60	MP0003935_abnormal_craniofacial_develop	1.14772061
61	MP0004134_abnormal_chest_morphology	1.13434796
62	MP0005410_abnormal_fertilization	1.12921881
63	MP0000163_abnormal_cartilage_morphology	1.12470105
64	MP0004742_abnormal_vestibular_system	1.11127797
65	MP0001486_abnormal_startle_reflex	1.09616955
66	MP0005389_reproductive_system_phenotype	1.08594658
67	MP0001119_abnormal_female_reproductive	1.06849720
68	MP0003698_abnormal_male_reproductive	1.04957194
69	MP0001270_distended_abdomen	1.03656770
70	MP0001501_abnormal_sleep_pattern	0.99816905
71	MP0000681_abnormal_thyroid_gland	0.99750377
72	MP0003252_abnormal_bile_duct	0.99209666
73	MP0003385_abnormal_body_wall	0.98975698
74	MP0005408_hypopigmentation	0.96968011
75	MP0000639_abnormal_adrenal_gland	0.96330186
76	MP0002736_abnormal_nociception_after	0.96142691
77	MP0002557_abnormal_social/conspecific_i	0.95151400
78	MP0004215_abnormal_myocardial_fiber	0.94861736
79	MP0002928_abnormal_bile_duct	0.93712224
80	MP0008875_abnormal_xenobiotic_pharmacok	0.91174563
81	MP0003699_abnormal_female_reproductive	0.88857026
82	MP0000026_abnormal_inner_ear	0.86782313
83	MP0001529_abnormal_vocalization	0.84952908
84	MP0005360_urolithiasis	0.84235180
85	MP0001963_abnormal_hearing_physiology	0.84232248
86	MP0006072_abnormal_retinal_apoptosis	0.83352752
87	MP0002109_abnormal_limb_morphology	0.82392494
88	MP0002116_abnormal_craniofacial_bone	0.82381464
89	MP0003936_abnormal_reproductive_system	0.78017890
90	MP0000427_abnormal_hair_cycle	0.76439202
91	MP0005195_abnormal_posterior_eye	0.75663565
92	MP0004233_abnormal_muscle_weight	0.75428543
93	MP0005253_abnormal_eye_physiology	0.75338934
94	MP0003937_abnormal_limbs/digits/tail_de	0.75327815
95	MP0005508_abnormal_skeleton_morphology	0.73803320
96	MP0002332_abnormal_exercise_endurance	0.72171468
97	MP0005395_other_phenotype	0.71556389
98	MP0003635_abnormal_synaptic_transmissio	0.70361970
99	MP0002752_abnormal_somatic_nervous	0.68462973
100	MP0002161_abnormal_fertility/fecundity	0.68139535

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gonadotropin excess (HP:0000837)	5.61207753
2	Wrist flexion contracture (HP:0001239)	5.06336080
3	Thyroid-stimulating hormone excess (HP:0002925)	4.43539688
4	Renal cortical cysts (HP:0000803)	4.29419207
5	Chronic hepatic failure (HP:0100626)	3.68747637
6	Renal dysplasia (HP:0000110)	3.56692208
7	Short tibia (HP:0005736)	3.40872684
8	Pancreatic fibrosis (HP:0100732)	3.33817552
9	Osteomalacia (HP:0002749)	3.31465337
10	Abnormal biliary tract physiology (HP:0012439)	3.19910163
11	Bile duct proliferation (HP:0001408)	3.19910163
12	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.19412708
13	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.09704119
14	Microglossia (HP:0000171)	2.98645769
15	Preauricular pit (HP:0004467)	2.74461441
16	Periauricular skin pits (HP:0100277)	2.74461441
17	True hermaphroditism (HP:0010459)	2.65677621
18	Pancreatic cysts (HP:0001737)	2.65130520
19	Abnormality of the renal cortex (HP:0011035)	2.64394927
20	Cholecystitis (HP:0001082)	2.58722215
21	Abnormal gallbladder physiology (HP:0012438)	2.58722215
22	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.58128797
23	Medial flaring of the eyebrow (HP:0010747)	2.53770181
24	Tented upper lip vermilion (HP:0010804)	2.46742596
25	Abnormality of midbrain morphology (HP:0002418)	2.40918916
26	Molar tooth sign on MRI (HP:0002419)	2.40918916
27	Hyperpituitarism (HP:0010514)	2.39645913
28	Follicular hyperkeratosis (HP:0007502)	2.39464777
29	Anterior segment dysgenesis (HP:0007700)	2.39403625
30	Type II lissencephaly (HP:0007260)	2.37292768
31	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.34362559
32	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.34230762
33	Enlarged kidneys (HP:0000105)	2.33629441
34	Bifid tongue (HP:0010297)	2.33314267
35	Alopecia of scalp (HP:0002293)	2.30674333
36	Tubulointerstitial nephritis (HP:0001970)	2.28349611
37	Congenital primary aphakia (HP:0007707)	2.28160133
38	Gait imbalance (HP:0002141)	2.26594611
39	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.26294958
40	Febrile seizures (HP:0002373)	2.26134231
41	Tubulointerstitial abnormality (HP:0001969)	2.25619685
42	Supernumerary spleens (HP:0009799)	2.25387341
43	Male infertility (HP:0003251)	2.21514882
44	Gaze-evoked nystagmus (HP:0000640)	2.20365637
45	Cortical dysplasia (HP:0002539)	2.20095353
46	Abnormality of the renal medulla (HP:0100957)	2.16862029
47	High anterior hairline (HP:0009890)	2.15688629
48	Genital tract atresia (HP:0001827)	2.13165646
49	Menstrual irregularities (HP:0000858)	2.12838003
50	Abnormal pancreas size (HP:0012094)	2.12486794
51	Retinal dysplasia (HP:0007973)	2.10477006
52	Hypoplasia of the uterus (HP:0000013)	2.08474923
53	Nephrogenic diabetes insipidus (HP:0009806)	2.08304468
54	Congenital sensorineural hearing impairment (HP:0008527)	2.07068869
55	Mesomelia (HP:0003027)	2.06715177
56	Dyskinesia (HP:0100660)	2.04302964
57	Severe Myopia (HP:0011003)	2.02828857
58	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.02316458
59	Astigmatism (HP:0000483)	2.01167796
60	Metaphyseal dysplasia (HP:0100255)	2.00363665
61	Postaxial hand polydactyly (HP:0001162)	2.00295673
62	Preaxial foot polydactyly (HP:0001841)	1.98908122
63	Premature ovarian failure (HP:0008209)	1.98582263
64	Hypercholesterolemia (HP:0003124)	1.98377684
65	Cupped ear (HP:0000378)	1.97458196
66	Prominent supraorbital ridges (HP:0000336)	1.97376947
67	Pachygyria (HP:0001302)	1.97359091
68	Intestinal atresia (HP:0011100)	1.96900705
69	Skin pits (HP:0100276)	1.96622608
70	Pancreatic islet-cell hyperplasia (HP:0004510)	1.94950606
71	Lip pit (HP:0100267)	1.94941546
72	Tubulointerstitial fibrosis (HP:0005576)	1.94709227
73	Median cleft lip (HP:0000161)	1.93758908
74	Facial hemangioma (HP:0000329)	1.93310065
75	Anencephaly (HP:0002323)	1.93112354
76	Abolished electroretinogram (ERG) (HP:0000550)	1.92549420
77	Optic nerve hypoplasia (HP:0000609)	1.92512550
78	Decreased muscle mass (HP:0003199)	1.92082275
79	Striae distensae (HP:0001065)	1.89572513
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89175620
81	Small hand (HP:0200055)	1.88510443
82	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.87688874
83	Abnormality of the aortic arch (HP:0012303)	1.87510481
84	Absent eyebrow (HP:0002223)	1.86997734
85	Occipital encephalocele (HP:0002085)	1.86698786
86	Broad palm (HP:0001169)	1.85398808
87	Papillary thyroid carcinoma (HP:0002895)	1.84114378
88	Abnormality of the pancreatic islet cells (HP:0006476)	1.83836647
89	Abnormality of endocrine pancreas physiology (HP:0012093)	1.83836647
90	Cystic liver disease (HP:0006706)	1.81745769
91	Increased corneal curvature (HP:0100692)	1.80610224
92	Keratoconus (HP:0000563)	1.80610224
93	Stenosis of the external auditory canal (HP:0000402)	1.77689453
94	Male pseudohermaphroditism (HP:0000037)	1.77114460
95	Morphological abnormality of the middle ear (HP:0008609)	1.74968051
96	Abnormality of abdominal situs (HP:0011620)	1.72576680
97	Abdominal situs inversus (HP:0003363)	1.72576680
98	Congenital hepatic fibrosis (HP:0002612)	1.70473433
99	White forelock (HP:0002211)	1.70005246
100	Impaired proprioception (HP:0010831)	1.68904040

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	8.39051421
2	EIF2AK3	4.49624670
3	ACVR1B	3.68865556
4	MUSK	3.62057391
5	BMPR1B	3.33380275
6	TAF1	2.62714945
7	MAP3K6	2.58684979
8	MAP3K4	2.22565169
9	PRKD3	2.06589704
10	PKN2	1.87820446
11	ZAK	1.83538497
12	NEK1	1.77042384
13	MAP2K7	1.73640935
14	PINK1	1.63119147
15	NUAK1	1.61433402
16	STK24	1.57765664
17	MAPK13	1.52712322
18	FRK	1.48631350
19	NTRK2	1.42488483
20	BRD4	1.39218639
21	BCR	1.39082399
22	TGFBR1	1.35456428
23	WNK3	1.34832058
24	TGFBR2	1.27190069
25	TYRO3	1.27096019
26	EPHA4	1.21779737
27	STK3	1.20118969
28	STK39	1.15308354
29	FLT3	1.12915438
30	OXSR1	1.08186894
31	CCNB1	1.02117933
32	SIK2	0.97797025
33	NEK6	0.95075002
34	LATS1	0.93376241
35	PAK3	0.92879385
36	NTRK3	0.92404109
37	PDK2	0.89056905
38	KSR2	0.87544003
39	CASK	0.86315981
40	EPHB2	0.85770305
41	DYRK1A	0.85284052
42	EIF2AK2	0.82462881
43	NLK	0.75583607
44	CSNK1G1	0.74725386
45	STK38L	0.74709647
46	INSRR	0.73408202
47	TNK2	0.72503542
48	MARK1	0.71759160
49	RAF1	0.69374597
50	PKN1	0.65260794
51	TTK	0.63844962
52	MAP2K4	0.62869440
53	PRKCE	0.58609121
54	PBK	0.56976013
55	MAP3K10	0.56642867
56	ADRBK2	0.55455202
57	ATR	0.54574540
58	TIE1	0.53457511
59	GRK7	0.52836362
60	ERBB3	0.51253044
61	MELK	0.50256433
62	STK16	0.48808333
63	CSNK1G2	0.45456481
64	MAPK7	0.44917592
65	NTRK1	0.42879363
66	PLK2	0.41883343
67	ATM	0.41854402
68	PLK3	0.41697682
69	CSNK1G3	0.41519295
70	STK11	0.40701520
71	WEE1	0.39579960
72	MAP2K1	0.37215002
73	PAK6	0.36988915
74	ADRBK1	0.36417254
75	KSR1	0.36394623
76	TNIK	0.35674473
77	BCKDK	0.33844121
78	GRK1	0.32629001
79	GRK5	0.32389532
80	PNCK	0.32275664
81	FER	0.31995411
82	WNK4	0.31602730
83	SIK3	0.31244995
84	RET	0.31138224
85	CDK9	0.30122763
86	PLK1	0.29921344
87	ERBB4	0.27932360
88	AURKA	0.26579185
89	PRKG1	0.25875147
90	PRKACA	0.25500022
91	VRK1	0.25110538
92	CSNK1D	0.24635658
93	MAP3K2	0.24522798
94	MAPK1	0.24194603
95	DYRK2	0.23189808
96	CDK8	0.22776461
97	PRKCZ	0.21967749
98	TRIM28	0.21552695
99	CDK5	0.20564328
100	SGK2	0.19094526

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.70217143
2	Basal transcription factors_Homo sapiens_hsa03022	3.39672718
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.07352826
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.80464193
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.78326989
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.69441075
7	ABC transporters_Homo sapiens_hsa02010	2.53743299
8	TGF-beta signaling pathway_Homo sapiens_hsa04350	2.52994795
9	Phototransduction_Homo sapiens_hsa04744	2.45444234
10	Circadian rhythm_Homo sapiens_hsa04710	2.00809322
11	Steroid biosynthesis_Homo sapiens_hsa00100	1.93994356
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.93205979
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.80072765
14	RNA degradation_Homo sapiens_hsa03018	1.78152824
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72469425
16	Fat digestion and absorption_Homo sapiens_hsa04975	1.71261858
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60192099
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.58487155
19	Nicotine addiction_Homo sapiens_hsa05033	1.55809980
20	Olfactory transduction_Homo sapiens_hsa04740	1.51622637
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.48830070
22	Protein export_Homo sapiens_hsa03060	1.47569692
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.38221401
24	Caffeine metabolism_Homo sapiens_hsa00232	1.37134840
25	Homologous recombination_Homo sapiens_hsa03440	1.34457127
26	Long-term depression_Homo sapiens_hsa04730	1.31876989
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.31160996
28	Butanoate metabolism_Homo sapiens_hsa00650	1.30652587
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.30346196
30	Fatty acid elongation_Homo sapiens_hsa00062	1.26233815
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22245494
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.21132852
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10197103
34	p53 signaling pathway_Homo sapiens_hsa04115	1.09156015
35	mTOR signaling pathway_Homo sapiens_hsa04150	1.08709608
36	Axon guidance_Homo sapiens_hsa04360	1.03281966
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03126241
38	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.00756687
39	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.99872126
40	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97234034
41	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97207438
42	GABAergic synapse_Homo sapiens_hsa04727	0.92063772
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.91993798
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.90120843
45	Serotonergic synapse_Homo sapiens_hsa04726	0.89191633
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89004081
47	Sphingolipid metabolism_Homo sapiens_hsa00600	0.88054105
48	Cocaine addiction_Homo sapiens_hsa05030	0.87770933
49	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.83395075
50	Oocyte meiosis_Homo sapiens_hsa04114	0.82895476
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80380007
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80168200
53	RNA polymerase_Homo sapiens_hsa03020	0.78819118
54	Melanoma_Homo sapiens_hsa05218	0.78761833
55	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.77323767
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77058489
57	Retinol metabolism_Homo sapiens_hsa00830	0.74639449
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.73638169
59	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.70707102
60	Peroxisome_Homo sapiens_hsa04146	0.69735851
61	Ras signaling pathway_Homo sapiens_hsa04014	0.68224074
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.66408776
63	Taste transduction_Homo sapiens_hsa04742	0.62951703
64	Type II diabetes mellitus_Homo sapiens_hsa04930	0.61481992
65	Tyrosine metabolism_Homo sapiens_hsa00350	0.60539484
66	Basal cell carcinoma_Homo sapiens_hsa05217	0.60534024
67	Morphine addiction_Homo sapiens_hsa05032	0.60276946
68	Regulation of autophagy_Homo sapiens_hsa04140	0.58983390
69	Bile secretion_Homo sapiens_hsa04976	0.58425715
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57743039
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57671404
72	Cholinergic synapse_Homo sapiens_hsa04725	0.56164881
73	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.55945398
74	Non-homologous end-joining_Homo sapiens_hsa03450	0.55110273
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.53665640
76	AMPK signaling pathway_Homo sapiens_hsa04152	0.53629474
77	Colorectal cancer_Homo sapiens_hsa05210	0.52664163
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52284472
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.52268482
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51527231
81	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.50354351
82	Lysine degradation_Homo sapiens_hsa00310	0.49603254
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49587825
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.49446102
85	Wnt signaling pathway_Homo sapiens_hsa04310	0.48327701
86	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46003158
87	Gap junction_Homo sapiens_hsa04540	0.45942657
88	Cell cycle_Homo sapiens_hsa04110	0.45402045
89	Adherens junction_Homo sapiens_hsa04520	0.44233912
90	Melanogenesis_Homo sapiens_hsa04916	0.44116414
91	Salivary secretion_Homo sapiens_hsa04970	0.44090571
92	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41742320
93	Prostate cancer_Homo sapiens_hsa05215	0.41696702
94	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.41000590
95	Insulin secretion_Homo sapiens_hsa04911	0.40169154
96	FoxO signaling pathway_Homo sapiens_hsa04068	0.40069172
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39488134
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.38578173
99	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.37637932
100	Base excision repair_Homo sapiens_hsa03410	0.37195931

NDUFB1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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