NDUFB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.58277006
2ATP synthesis coupled proton transport (GO:0015986)6.97655079
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.97655079
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.85220110
5* respiratory electron transport chain (GO:0022904)6.41965938
6* electron transport chain (GO:0022900)6.25192388
7establishment of protein localization to mitochondrial membrane (GO:0090151)6.21372988
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.21659112
9cotranslational protein targeting to membrane (GO:0006613)5.17693718
10protein targeting to ER (GO:0045047)5.15661434
11ribosomal small subunit assembly (GO:0000028)5.14747592
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.92992284
13protein localization to endoplasmic reticulum (GO:0070972)4.90701946
14translational elongation (GO:0006414)4.71456202
15transcription elongation from RNA polymerase III promoter (GO:0006385)4.55640320
16termination of RNA polymerase III transcription (GO:0006386)4.55640320
17maturation of SSU-rRNA (GO:0030490)4.27158448
18viral life cycle (GO:0019058)4.21925056
19oxidative phosphorylation (GO:0006119)4.20439530
20cellular protein complex disassembly (GO:0043624)4.18695211
21translation (GO:0006412)4.06129531
22translational initiation (GO:0006413)3.95896524
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.94034550
24protein targeting to mitochondrion (GO:0006626)3.86944235
25hydrogen ion transmembrane transport (GO:1902600)3.85949559
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75533334
27protein complex biogenesis (GO:0070271)3.73740442
28establishment of protein localization to mitochondrion (GO:0072655)3.73627002
29DNA deamination (GO:0045006)3.72946567
30rRNA modification (GO:0000154)3.65588129
31intracellular protein transmembrane import (GO:0044743)3.65045491
32regulation of cellular amino acid metabolic process (GO:0006521)3.64320422
33protein localization to mitochondrion (GO:0070585)3.59467662
34ribosomal large subunit biogenesis (GO:0042273)3.56196196
35pseudouridine synthesis (GO:0001522)3.55868718
36mitochondrial transport (GO:0006839)3.51060762
37ATP biosynthetic process (GO:0006754)3.46391204
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.45749750
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45102660
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45102660
41respiratory chain complex IV assembly (GO:0008535)3.44510444
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44355065
43proton transport (GO:0015992)3.42650459
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.42383183
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41637053
46negative regulation of ligase activity (GO:0051352)3.41637053
47protein targeting to membrane (GO:0006612)3.41429293
48protein complex disassembly (GO:0043241)3.40394974
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.39035939
50cellular component biogenesis (GO:0044085)3.39025540
51protein-cofactor linkage (GO:0018065)3.37839217
52positive regulation of action potential (GO:0045760)3.35279531
53regulation of mitochondrial translation (GO:0070129)3.34550887
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34496162
55hydrogen transport (GO:0006818)3.34181364
56water-soluble vitamin biosynthetic process (GO:0042364)3.33511438
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31261958
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.31261958
59NADH dehydrogenase complex assembly (GO:0010257)3.31261958
60cytochrome complex assembly (GO:0017004)3.30533951
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.29903792
62purine nucleoside triphosphate biosynthetic process (GO:0009145)3.29623630
63GTP biosynthetic process (GO:0006183)3.28355112
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.27907769
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.27907769
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.27907769
67purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.27849166
68purine nucleoside monophosphate biosynthetic process (GO:0009127)3.27849166
69macromolecular complex disassembly (GO:0032984)3.27678963
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26169440
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26169440
72mitochondrial respiratory chain complex assembly (GO:0033108)3.23552891
73ribosomal small subunit biogenesis (GO:0042274)3.21685679
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.20015631
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19542294
76sarcoplasmic reticulum calcium ion transport (GO:0070296)3.18953521
77superoxide anion generation (GO:0042554)3.16241324
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12995339
79signal transduction involved in DNA damage checkpoint (GO:0072422)3.12995339
80response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.09820928
81signal transduction involved in cell cycle checkpoint (GO:0072395)3.09612972
82platelet dense granule organization (GO:0060155)3.07541046
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05864311
84sequestering of actin monomers (GO:0042989)3.05718054
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98152007
86righting reflex (GO:0060013)2.96773130
87cullin deneddylation (GO:0010388)2.91638013
88nuclear-transcribed mRNA catabolic process (GO:0000956)2.91634951
89cardiac right ventricle morphogenesis (GO:0003215)2.87457339
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.84415617
91positive regulation of ligase activity (GO:0051351)2.82394294
92regulation of oxidative phosphorylation (GO:0002082)2.81989721
93protein neddylation (GO:0045116)2.81255645
94negative regulation of protein localization to cell surface (GO:2000009)2.80980119
95spliceosomal snRNP assembly (GO:0000387)2.80112578
96quinone biosynthetic process (GO:1901663)2.79785336
97ubiquinone biosynthetic process (GO:0006744)2.79785336
98ribonucleoside monophosphate biosynthetic process (GO:0009156)2.78952860
99intracellular protein transmembrane transport (GO:0065002)2.78620546
100base-excision repair, AP site formation (GO:0006285)2.77717699
101nucleoside monophosphate biosynthetic process (GO:0009124)2.77496732
102neuron cell-cell adhesion (GO:0007158)2.70891841
103central nervous system myelination (GO:0022010)2.70616545
104axon ensheathment in central nervous system (GO:0032291)2.70616545
105viral transcription (GO:0019083)2.69078786
106GPI anchor biosynthetic process (GO:0006506)2.66714926
107response to redox state (GO:0051775)2.63294397
108polyketide metabolic process (GO:0030638)2.60840837
109doxorubicin metabolic process (GO:0044598)2.60840837
110daunorubicin metabolic process (GO:0044597)2.60840837
111keratinocyte development (GO:0003334)2.60839945
112chaperone-mediated protein transport (GO:0072321)2.59484625
113limb bud formation (GO:0060174)2.59333949
114preassembly of GPI anchor in ER membrane (GO:0016254)2.59229550
115short-term memory (GO:0007614)2.58968233
116long-chain fatty acid biosynthetic process (GO:0042759)2.58516995
117calcium-mediated signaling using intracellular calcium source (GO:0035584)2.56946734
118regulation of timing of cell differentiation (GO:0048505)2.54748940
119regulation of platelet aggregation (GO:0090330)2.54293509
120aerobic respiration (GO:0009060)2.50265765
121inner mitochondrial membrane organization (GO:0007007)2.50212943
122retina layer formation (GO:0010842)2.50113509
123translational termination (GO:0006415)2.49008347
124cranial nerve morphogenesis (GO:0021602)2.48555672
125ubiquinone metabolic process (GO:0006743)2.47681789
126postsynaptic membrane organization (GO:0001941)2.47120854
127negative regulation of heart rate (GO:0010459)2.45877319
128ionotropic glutamate receptor signaling pathway (GO:0035235)2.45262904
129regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.44249106
130cellular respiration (GO:0045333)2.43988272
131cellular response to epinephrine stimulus (GO:0071872)2.43126684
132response to epinephrine (GO:0071871)2.42063165
133cranial nerve development (GO:0021545)2.41234216
134glutamate receptor signaling pathway (GO:0007215)2.41037506
135negative regulation of homotypic cell-cell adhesion (GO:0034111)2.41032082
136positive regulation of protein kinase C signaling (GO:0090037)2.40151212
137nucleoside triphosphate biosynthetic process (GO:0009142)2.39253036
138positive regulation of cellular amine metabolic process (GO:0033240)2.39168693
139GPI anchor metabolic process (GO:0006505)2.38731263
140UTP biosynthetic process (GO:0006228)2.38346212
141superoxide metabolic process (GO:0006801)2.38129197
142regulation of cell communication by electrical coupling (GO:0010649)2.37404497
143mitochondrion morphogenesis (GO:0070584)2.36967030
144adenosine metabolic process (GO:0046085)2.36964020
145presynaptic membrane assembly (GO:0097105)2.36466181
146G-protein coupled receptor internalization (GO:0002031)2.33278664
147regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.32773308
148negative regulation of cAMP-mediated signaling (GO:0043951)2.30123671
149regulation of dopamine metabolic process (GO:0042053)2.29565309
150regulation of catecholamine metabolic process (GO:0042069)2.29565309
151cerebral cortex radially oriented cell migration (GO:0021799)2.29008828
152regulation of action potential (GO:0098900)2.28945694
153spinal cord association neuron differentiation (GO:0021527)2.27858545
154regulation of development, heterochronic (GO:0040034)2.27384587
155forebrain neuron development (GO:0021884)2.27227399
156proteasome assembly (GO:0043248)2.25591134
157positive regulation of vascular permeability (GO:0043117)2.25314446
158positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.24818027
159presynaptic membrane organization (GO:0097090)2.24513205
160protein localization to synapse (GO:0035418)2.24254892
161transmission of nerve impulse (GO:0019226)2.23659217
162positive regulation of prostaglandin secretion (GO:0032308)2.23477508
163mesenchymal cell differentiation involved in renal system development (GO:2001012)2.22790575
164mesenchymal cell differentiation involved in kidney development (GO:0072161)2.22790575
165regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.21709842
166G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.21600366
167vocalization behavior (GO:0071625)2.21586343
168negative regulation of myoblast differentiation (GO:0045662)2.21288576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.26737111
2GABP_17652178_ChIP-ChIP_JURKAT_Human5.02924284
3EZH2_22144423_ChIP-Seq_EOC_Human5.01445177
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.44555414
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.99190758
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.61741810
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.51820626
8GBX2_23144817_ChIP-Seq_PC3_Human3.39923540
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18187216
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12447809
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01138444
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.00556012
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.94397113
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.93907363
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91507206
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76779261
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.66698832
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.61192114
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.58923790
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54748706
21VDR_23849224_ChIP-Seq_CD4+_Human2.50514649
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.43368378
23ELK1_19687146_ChIP-ChIP_HELA_Human2.37451427
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36676447
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34339435
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34297865
27IGF1R_20145208_ChIP-Seq_DFB_Human2.32169653
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32138421
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31022213
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30607136
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29089104
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24551978
33BP1_19119308_ChIP-ChIP_Hs578T_Human2.24012030
34CBX2_27304074_Chip-Seq_ESCs_Mouse2.23734591
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20503030
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18862910
37PCGF2_27294783_Chip-Seq_ESCs_Mouse2.18843223
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18325637
39FOXP3_21729870_ChIP-Seq_TREG_Human2.16865574
40VDR_22108803_ChIP-Seq_LS180_Human2.15514960
41ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12759478
42YY1_21170310_ChIP-Seq_MESCs_Mouse2.10921935
43EZH2_27294783_Chip-Seq_ESCs_Mouse2.10813479
44RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10759743
45EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10759743
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08838051
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07963752
48* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07737695
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94662546
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92733990
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.91887727
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90460712
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.85098358
54* XRN2_22483619_ChIP-Seq_HELA_Human1.84763445
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82094354
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80927926
57* TTF2_22483619_ChIP-Seq_HELA_Human1.80606408
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80495392
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80417319
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79878518
61MYC_18940864_ChIP-ChIP_HL60_Human1.76488062
62DCP1A_22483619_ChIP-Seq_HELA_Human1.76007723
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74549504
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73730759
65TAF15_26573619_Chip-Seq_HEK293_Human1.72907451
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.72720293
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71186802
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.70938039
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.69692500
70GABP_19822575_ChIP-Seq_HepG2_Human1.68006171
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67122983
72RNF2_27304074_Chip-Seq_NSC_Mouse1.66396601
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65331267
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64532580
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60849531
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58432107
77P300_19829295_ChIP-Seq_ESCs_Human1.52458430
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52155004
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50812145
80REST_21632747_ChIP-Seq_MESCs_Mouse1.48323316
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.46910279
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43550267
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42131331
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39508000
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.38716709
86P53_22387025_ChIP-Seq_ESCs_Mouse1.36328818
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.35627501
88* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35592526
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.35518632
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33684505
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33643028
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32956528
93* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32784399
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31582198
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30995449
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.30376196
97ZNF274_21170338_ChIP-Seq_K562_Hela1.29430585
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28918055
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.27976845
100TP53_22573176_ChIP-Seq_HFKS_Human1.27724296
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26778801
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25969460
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25729357
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24976850
105P300_18555785_Chip-Seq_ESCs_Mouse1.23729692
106DROSHA_22980978_ChIP-Seq_HELA_Human1.23505650
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.22299188
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21637066
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.21313242
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.19118950
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18117494
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17850400
113ZFX_18555785_Chip-Seq_ESCs_Mouse1.17295295
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.16709828
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15509152
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15509152
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.15470813
118CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14997105
119FUS_26573619_Chip-Seq_HEK293_Human1.14149387
120ER_23166858_ChIP-Seq_MCF-7_Human1.14060978
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.13315371
122ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12960503
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12524858
124SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12219123
125SMAD4_21799915_ChIP-Seq_A2780_Human1.11807816
126E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11494037
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11357640
128TAL1_26923725_Chip-Seq_HPCs_Mouse1.09152241
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08587925
130IRF1_19129219_ChIP-ChIP_H3396_Human1.07746610
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07360082
132NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06417575
133CTCF_18555785_Chip-Seq_ESCs_Mouse1.05800681
134CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05324879
135PU1_27457419_Chip-Seq_LIVER_Mouse1.05255026
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04062355
137EWS_26573619_Chip-Seq_HEK293_Human1.03471443
138HTT_18923047_ChIP-ChIP_STHdh_Human1.01328345
139SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00327122
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99963449
141* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99618297
142P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99464314
143CRX_20693478_ChIP-Seq_RETINA_Mouse0.98436822
144RING1B_27294783_Chip-Seq_ESCs_Mouse0.97463824
145PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97303469
146RUNX2_22187159_ChIP-Seq_PCA_Human0.97184227
147FOXA1_25329375_ChIP-Seq_VCAP_Human0.96327886
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96327886
149ERG_20517297_ChIP-Seq_VCAP_Human0.95518174
150* AR_20517297_ChIP-Seq_VCAP_Human0.95201865
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94547137
152POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93749796
153OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92887128
154TP53_20018659_ChIP-ChIP_R1E_Mouse0.92587418
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91465856
156KDM2B_26808549_Chip-Seq_REH_Human0.91168619
157DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90981700
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90763205
159AR_21572438_ChIP-Seq_LNCaP_Human0.90242109
160PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90195119
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89874056
162SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89319330
163MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89268022
164CTCF_27219007_Chip-Seq_Bcells_Human0.89177293
165NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89128490
166EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88715395
167TP53_18474530_ChIP-ChIP_U2OS_Human0.86994875
168CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86800514
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86745767
170GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86445677
171SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86134176
172NCOR_22424771_ChIP-Seq_293T_Human0.84697507
173* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84632182
174TAF2_19829295_ChIP-Seq_ESCs_Human0.84228779
175POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83941687
176FOXP1_21924763_ChIP-Seq_HESCs_Human0.83358388
177KDM5A_27292631_Chip-Seq_BREAST_Human0.83302116
178SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83140059
179GATA3_21878914_ChIP-Seq_MCF-7_Human0.82934996
180NANOG_20526341_ChIP-Seq_ESCs_Human0.82120539
181MYC_19829295_ChIP-Seq_ESCs_Human0.81775860
182FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.79404799
183NANOG_19829295_ChIP-Seq_ESCs_Human0.79150622
184SOX2_19829295_ChIP-Seq_ESCs_Human0.79150622
185RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76891145
186STAT1_20625510_ChIP-Seq_HELA_Human0.76301986
187SOX2_16153702_ChIP-ChIP_HESCs_Human0.76247239
188FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73513058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.59020043
2MP0009379_abnormal_foot_pigmentation3.39556338
3MP0001188_hyperpigmentation3.23516223
4MP0003880_abnormal_central_pattern3.09676979
5MP0003186_abnormal_redox_activity2.80397154
6MP0003806_abnormal_nucleotide_metabolis2.76092101
7MP0006292_abnormal_olfactory_placode2.71778682
8MP0003136_yellow_coat_color2.63604615
9MP0000566_synostosis2.61092304
10MP0006276_abnormal_autonomic_nervous2.54538787
11MP0000372_irregular_coat_pigmentation2.49636770
12MP0002938_white_spotting2.45678466
13MP0001486_abnormal_startle_reflex2.31102802
14MP0004142_abnormal_muscle_tone2.28310590
15MP0002735_abnormal_chemical_nociception2.22005323
16MP0004381_abnormal_hair_follicle2.18775823
17MP0005451_abnormal_body_composition2.14145583
18MP0001968_abnormal_touch/_nociception2.00972140
19MP0002277_abnormal_respiratory_mucosa1.98181292
20MP0003786_premature_aging1.98021411
21MP0004147_increased_porphyrin_level1.89491778
22MP0005409_darkened_coat_color1.85281421
23MP0009046_muscle_twitch1.85119351
24MP0001529_abnormal_vocalization1.83587895
25MP0002736_abnormal_nociception_after1.82308510
26MP0005084_abnormal_gallbladder_morpholo1.81826268
27MP0000751_myopathy1.79161253
28MP0008058_abnormal_DNA_repair1.78337631
29MP0004742_abnormal_vestibular_system1.77445445
30MP0002638_abnormal_pupillary_reflex1.72493578
31MP0009745_abnormal_behavioral_response1.70537243
32MP0001986_abnormal_taste_sensitivity1.68463737
33MP0004145_abnormal_muscle_electrophysio1.67052429
34MP0005423_abnormal_somatic_nervous1.66605358
35MP0002837_dystrophic_cardiac_calcinosis1.66143731
36MP0006035_abnormal_mitochondrial_morpho1.64900516
37MP0002272_abnormal_nervous_system1.64556772
38MP0003195_calcinosis1.63686401
39MP0001440_abnormal_grooming_behavior1.63541509
40MP0008875_abnormal_xenobiotic_pharmacok1.61256356
41MP0005645_abnormal_hypothalamus_physiol1.57527876
42MP0004215_abnormal_myocardial_fiber1.55533177
43MP0003137_abnormal_impulse_conducting1.55065450
44MP0006072_abnormal_retinal_apoptosis1.53471912
45MP0005257_abnormal_intraocular_pressure1.53061458
46MP0003646_muscle_fatigue1.51523652
47MP0000026_abnormal_inner_ear1.49085858
48MP0001501_abnormal_sleep_pattern1.48890952
49MP0003941_abnormal_skin_development1.48623948
50MP0000749_muscle_degeneration1.48103558
51MP0000462_abnormal_digestive_system1.47638905
52MP0002876_abnormal_thyroid_physiology1.45829624
53MP0003938_abnormal_ear_development1.45147724
54MP0005646_abnormal_pituitary_gland1.44466493
55MP0002734_abnormal_mechanical_nocicepti1.42176471
56MP0008872_abnormal_physiological_respon1.40474840
57MP0005332_abnormal_amino_acid1.38879449
58MP0001485_abnormal_pinna_reflex1.38335650
59MP0002067_abnormal_sensory_capabilities1.37362283
60MP0001970_abnormal_pain_threshold1.37066050
61MP0005379_endocrine/exocrine_gland_phen1.36689033
62MP0002572_abnormal_emotion/affect_behav1.36541931
63MP0001905_abnormal_dopamine_level1.35075246
64MP0005551_abnormal_eye_electrophysiolog1.34380466
65MP0003718_maternal_effect1.33039646
66MP0003635_abnormal_synaptic_transmissio1.32677413
67MP0002064_seizures1.32078622
68MP0004859_abnormal_synaptic_plasticity1.29754265
69MP0004484_altered_response_of1.27808931
70MP0002184_abnormal_innervation1.27760783
71MP0008995_early_reproductive_senescence1.27658803
72MP0002733_abnormal_thermal_nociception1.27197640
73MP0005174_abnormal_tail_pigmentation1.26287211
74MP0008877_abnormal_DNA_methylation1.25358518
75MP0004270_analgesia1.24715553
76MP0001963_abnormal_hearing_physiology1.23586918
77MP0002332_abnormal_exercise_endurance1.22256987
78MP0000049_abnormal_middle_ear1.21352966
79MP0005408_hypopigmentation1.21225580
80MP0005171_absent_coat_pigmentation1.21090914
81MP0002095_abnormal_skin_pigmentation1.17091769
82MP0002752_abnormal_somatic_nervous1.16515889
83MP0001727_abnormal_embryo_implantation1.15610822
84MP0000778_abnormal_nervous_system1.13808075
85MP0005377_hearing/vestibular/ear_phenot1.13183509
86MP0003878_abnormal_ear_physiology1.13183509
87MP0010386_abnormal_urinary_bladder1.12942824
88MP0002160_abnormal_reproductive_system1.12677978
89MP0005330_cardiomyopathy1.12513367
90MP0001764_abnormal_homeostasis1.11379830
91MP0000579_abnormal_nail_morphology1.10400407
92MP0003123_paternal_imprinting1.10295116
93MP0002557_abnormal_social/conspecific_i1.09608012
94MP0004133_heterotaxia1.07893509
95MP0001984_abnormal_olfaction1.06013714
96MP0004043_abnormal_pH_regulation1.05924426
97MP0000750_abnormal_muscle_regeneration1.05375109
98MP0003315_abnormal_perineum_morphology1.02551836
99MP0005075_abnormal_melanosome_morpholog1.02194601
100MP0003787_abnormal_imprinting1.01136672
101MP0005389_reproductive_system_phenotype1.00341750
102MP0008004_abnormal_stomach_pH0.99983108
103MP0003011_delayed_dark_adaptation0.97983322
104MP0005253_abnormal_eye_physiology0.97764971
105MP0005636_abnormal_mineral_homeostasis0.97696001
106MP0002751_abnormal_autonomic_nervous0.94709782
107MP0008789_abnormal_olfactory_epithelium0.94091256
108MP0002163_abnormal_gland_morphology0.93595351
109MP0006036_abnormal_mitochondrial_physio0.92991356
110MP0002063_abnormal_learning/memory/cond0.90734946
111MP0005410_abnormal_fertilization0.90138419
112MP0000015_abnormal_ear_pigmentation0.90077704
113MP0000631_abnormal_neuroendocrine_gland0.89971851
114MP0001756_abnormal_urination0.89311578
115MP0002249_abnormal_larynx_morphology0.87976138
116MP0001664_abnormal_digestion0.86895263
117MP0003828_pulmonary_edema0.86660711
118MP0004085_abnormal_heartbeat0.85917008
119MP0010030_abnormal_orbit_morphology0.85352320
120MP0000762_abnormal_tongue_morphology0.84878834
121MP0004019_abnormal_vitamin_homeostasis0.82348775
122MP0003121_genomic_imprinting0.81279682
123MP0001919_abnormal_reproductive_system0.81238972
124MP0004885_abnormal_endolymph0.81212903
125MP0002882_abnormal_neuron_morphology0.80407688
126MP0003879_abnormal_hair_cell0.78171268
127MP0005620_abnormal_muscle_contractility0.78127154
128MP0003950_abnormal_plasma_membrane0.77826994
129MP0002822_catalepsy0.77577236
130MP0002653_abnormal_ependyma_morphology0.77387886
131MP0004924_abnormal_behavior0.76432478
132MP0005386_behavior/neurological_phenoty0.76432478
133MP0008260_abnormal_autophagy0.76391582
134MP0002090_abnormal_vision0.75216646
135MP0002210_abnormal_sex_determination0.74526283
136MP0004957_abnormal_blastocyst_morpholog0.74082159
137MP0005165_increased_susceptibility_to0.73775389
138MP0002066_abnormal_motor_capabilities/c0.73120287
139MP0005584_abnormal_enzyme/coenzyme_acti0.72856050
140MP0005381_digestive/alimentary_phenotyp0.72365377
141MP0005195_abnormal_posterior_eye0.71869032
142MP0005671_abnormal_response_to0.71539993
143MP0000343_altered_response_to0.70648724
144MP0005670_abnormal_white_adipose0.68705321
145MP0005266_abnormal_metabolism0.65784217
146MP0002234_abnormal_pharynx_morphology0.65716043

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.46392886
2Abnormal mitochondria in muscle tissue (HP:0008316)4.72184659
3Mitochondrial inheritance (HP:0001427)4.62312741
4Progressive macrocephaly (HP:0004481)4.42422564
5Acute encephalopathy (HP:0006846)4.36645128
6Increased hepatocellular lipid droplets (HP:0006565)4.05097415
7Increased CSF lactate (HP:0002490)3.75186092
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.70671765
9Abnormal number of erythroid precursors (HP:0012131)3.67067746
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.57575605
11Lipid accumulation in hepatocytes (HP:0006561)3.47814970
12Renal Fanconi syndrome (HP:0001994)3.44797342
13Optic disc pallor (HP:0000543)3.43292783
14Hepatocellular necrosis (HP:0001404)3.37481373
15Cerebral edema (HP:0002181)3.31287360
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.27846095
17Hepatic necrosis (HP:0002605)3.19874413
18Chromsome breakage (HP:0040012)3.15402420
19Type II lissencephaly (HP:0007260)3.04162497
20Upper limb muscle weakness (HP:0003484)3.03290470
21Congenital, generalized hypertrichosis (HP:0004540)2.95619325
223-Methylglutaconic aciduria (HP:0003535)2.95373387
23Exercise intolerance (HP:0003546)2.91598558
24Parakeratosis (HP:0001036)2.90798513
25Focal motor seizures (HP:0011153)2.85218722
26Respiratory difficulties (HP:0002880)2.83207706
27Microvesicular hepatic steatosis (HP:0001414)2.80650835
28Aplasia cutis congenita (HP:0001057)2.78339844
29Lactic acidosis (HP:0003128)2.73118808
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72912811
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72912811
32Lethargy (HP:0001254)2.72072827
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.68356147
34Absent/shortened dynein arms (HP:0200106)2.68356147
35CNS demyelination (HP:0007305)2.66578013
36Increased intramyocellular lipid droplets (HP:0012240)2.65032957
37Reticulocytopenia (HP:0001896)2.64636490
38Febrile seizures (HP:0002373)2.62612762
39Abnormal ciliary motility (HP:0012262)2.59679357
40Muscle hypertrophy of the lower extremities (HP:0008968)2.58330334
41Respiratory failure (HP:0002878)2.57245774
42Hypoplasia of the pons (HP:0012110)2.56953394
43Congenital sensorineural hearing impairment (HP:0008527)2.53273695
44Cerebellar dysplasia (HP:0007033)2.52218256
45Abnormality of midbrain morphology (HP:0002418)2.48014461
46Molar tooth sign on MRI (HP:0002419)2.48014461
47Abnormality of renal resorption (HP:0011038)2.45271154
48Sudden death (HP:0001699)2.42703093
49Generalized aminoaciduria (HP:0002909)2.41228737
50Prolonged QT interval (HP:0001657)2.40477357
51Exertional dyspnea (HP:0002875)2.40273175
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.39378004
53Retinal dysplasia (HP:0007973)2.39142376
54Calf muscle hypertrophy (HP:0008981)2.37667633
55Abnormality of the pons (HP:0007361)2.36271058
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36204278
57Methylmalonic aciduria (HP:0012120)2.35737261
58Pancreatic cysts (HP:0001737)2.32927770
59Increased serum lactate (HP:0002151)2.31985346
60Type I transferrin isoform profile (HP:0003642)2.29546709
61Pancreatic fibrosis (HP:0100732)2.29542980
62Decreased central vision (HP:0007663)2.28434755
63Duplicated collecting system (HP:0000081)2.28044878
64Syncope (HP:0001279)2.23618210
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22446075
66Congenital stationary night blindness (HP:0007642)2.21788477
67Myokymia (HP:0002411)2.21520527
68Increased serum pyruvate (HP:0003542)2.20308622
69Aplastic anemia (HP:0001915)2.19829042
70Abnormal respiratory motile cilium morphology (HP:0005938)2.19190115
71Abnormal respiratory epithelium morphology (HP:0012253)2.19190115
72Concave nail (HP:0001598)2.16621613
73Leukodystrophy (HP:0002415)2.15248753
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15076947
75Septo-optic dysplasia (HP:0100842)2.13833387
76Emotional lability (HP:0000712)2.12952894
77Pallor (HP:0000980)2.12824188
78Duplication of thumb phalanx (HP:0009942)2.12386525
79Increased muscle lipid content (HP:0009058)2.12198801
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12148298
81Dicarboxylic aciduria (HP:0003215)2.12148298
82Retinal atrophy (HP:0001105)2.09125856
83True hermaphroditism (HP:0010459)2.08879574
84Prostate neoplasm (HP:0100787)2.08863386
85Abnormal respiratory motile cilium physiology (HP:0012261)2.08173578
86Abnormality of the renal collecting system (HP:0004742)2.05927688
87Anomalous pulmonary venous return (HP:0010772)2.05288726
88Nasolacrimal duct obstruction (HP:0000579)2.04848945
89Abnormality of the axillary hair (HP:0100134)2.03783676
90Abnormality of secondary sexual hair (HP:0009888)2.03783676
91Oral leukoplakia (HP:0002745)2.02256235
92Atrial fibrillation (HP:0005110)2.01603262
93Progressive external ophthalmoplegia (HP:0000590)1.98523463
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98244549
95Nephronophthisis (HP:0000090)1.96524062
96Abnormality of urine glucose concentration (HP:0011016)1.96031060
97Glycosuria (HP:0003076)1.96031060
98Distal lower limb muscle weakness (HP:0009053)1.92920204
99Primary atrial arrhythmia (HP:0001692)1.92783867
100Renal cortical cysts (HP:0000803)1.91596069
101Abnormal EKG (HP:0003115)1.91127797
102Sclerocornea (HP:0000647)1.90401794
103Cerebral hypomyelination (HP:0006808)1.89328174
104Supraventricular tachycardia (HP:0004755)1.88960633
105Congenital malformation of the right heart (HP:0011723)1.88112156
106Double outlet right ventricle (HP:0001719)1.88112156
107Methylmalonic acidemia (HP:0002912)1.86094930
108Blindness (HP:0000618)1.85508860
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85236230
110Abnormal protein N-linked glycosylation (HP:0012347)1.85236230
111Abnormal protein glycosylation (HP:0012346)1.85236230
112Abnormal glycosylation (HP:0012345)1.85236230
113X-linked dominant inheritance (HP:0001423)1.84531107
114Partial duplication of thumb phalanx (HP:0009944)1.84204106
115Abnormal urine phosphate concentration (HP:0012599)1.83770050
116Abolished electroretinogram (ERG) (HP:0000550)1.83434147
117Abnormality of the lacrimal duct (HP:0011481)1.83212985
118Abnormality of alanine metabolism (HP:0010916)1.83013092
119Hyperalaninemia (HP:0003348)1.83013092
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83013092
121Overfolded helix (HP:0000396)1.81102038
122Testicular atrophy (HP:0000029)1.80546170
123Abnormality of glycolysis (HP:0004366)1.80492622
124Macrocytic anemia (HP:0001972)1.79713666
125Hypothermia (HP:0002045)1.79628895
126Metabolic alkalosis (HP:0200114)1.79394806
127Abnormality of the pulmonary veins (HP:0011718)1.78782548
128Pancytopenia (HP:0001876)1.78433711
129Hyperglycinemia (HP:0002154)1.77260627
130Supraventricular arrhythmia (HP:0005115)1.76969984
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75848534
132Vomiting (HP:0002013)1.75395329
133Colon cancer (HP:0003003)1.75382891
134Renal tubular dysfunction (HP:0000124)1.75128563
135Severe muscular hypotonia (HP:0006829)1.73315247
136Ventricular tachycardia (HP:0004756)1.73131604
137Hyperphosphaturia (HP:0003109)1.72350749
138Abnormality of the calf musculature (HP:0001430)1.70808349
139Abnormality of cells of the erythroid lineage (HP:0012130)1.70103017
140Gliosis (HP:0002171)1.69511340
141Medial flaring of the eyebrow (HP:0010747)1.68597743
142Patchy hypopigmentation of hair (HP:0011365)1.67509510
143Ulnar claw (HP:0001178)1.67421117
144Abnormality of the preputium (HP:0100587)1.66950124
145Amniotic constriction ring (HP:0009775)1.63304342
146Abnormality of placental membranes (HP:0011409)1.63304342
147Progressive microcephaly (HP:0000253)1.59088077
148Aplasia/hypoplasia of the uterus (HP:0008684)1.57612185
149Aplasia/Hypoplasia affecting the retina (HP:0008061)1.57049274
150Absent thumb (HP:0009777)1.56090496
151Nausea (HP:0002018)1.54207767
152Large for gestational age (HP:0001520)1.51897432
153Abnormality of the anterior horn cell (HP:0006802)1.50621918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.09511924
2CASK3.82430356
3TNIK3.40300513
4STK163.34644264
5MUSK2.76334560
6NME12.51059647
7BUB12.47580613
8INSRR2.40442190
9PINK12.22606616
10TLK12.15764676
11EIF2AK22.14221549
12BCKDK2.09330255
13NTRK32.03149400
14NME22.00363495
15PKN11.98667980
16MST41.97060331
17GRK11.96990873
18GRK71.93498027
19OBSCN1.85454317
20ADRBK21.85141615
21PDK21.85047089
22ZAK1.78915281
23STK391.71828789
24PRPF4B1.67788853
25IRAK31.58409527
26BLK1.57480492
27MAP4K21.56115867
28TESK21.53658509
29GRK51.47584245
30LIMK11.47540809
31WNK41.39579932
32EPHB21.31273746
33FRK1.30938018
34CAMK11.30668852
35TESK11.29231189
36MAPK71.27196110
37MAP2K71.25804993
38PNCK1.25584803
39PIM21.24254720
40KDR1.24026418
41MST1R1.21991759
42CSNK1G31.20624294
43OXSR11.20081207
44MARK11.19412860
45MARK31.19056729
46CAMK2D1.17849019
47LMTK21.16044766
48SIK21.15280600
49RIPK41.14202678
50PBK1.12207565
51CDC71.11340455
52PHKG21.10986335
53PHKG11.10986335
54CSNK1G21.10670164
55BMPR1B1.08789702
56NEK11.05559277
57MAPK151.03357336
58MAPK131.02855924
59CSNK1G10.99830170
60DAPK20.99666114
61TAF10.99315159
62PIK3CG0.99168992
63CAMK2B0.98686905
64CAMK2A0.98394147
65IRAK20.97524045
66ARAF0.96490484
67MYLK0.95021393
68ILK0.93933423
69WNK30.86674732
70EIF2AK10.85871822
71PLK30.85493774
72CCNB10.84546881
73PIK3CA0.83588258
74VRK10.81994458
75DYRK20.79459602
76CAMK2G0.79189050
77PRKCG0.79140563
78MKNK20.79100920
79IRAK40.76494964
80DAPK10.76048132
81YES10.76009902
82NTRK20.74120728
83DAPK30.73785637
84STK100.72930444
85ADRBK10.72745902
86CSNK1A1L0.72199146
87FES0.70861545
88PRKCE0.70432354
89EPHA40.70107796
90CDK30.69821371
91TAOK30.69794496
92ABL20.69500983
93PRKACA0.68916082
94TRIM280.67228301
95PLK40.65010336
96WNK10.64696539
97MAP3K40.64254263
98MARK20.64192576
99CSNK2A20.63966697
100SRPK10.62833787
101NUAK10.62662692
102PLK10.61643571
103PRKAA20.60847516
104PAK30.60143262
105TXK0.60127038
106AURKA0.59887248
107MAPK120.58618849
108CSNK2A10.58106239
109NEK60.57094547
110CLK10.55457221
111MAP3K110.55445124
112CAMKK20.54787244
113FGR0.54102012
114CAMK40.53638143
115AURKB0.53445564
116TNK20.53375279
117IRAK10.52401046
118EIF2AK30.51970049
119UHMK10.51121925
120PRKD20.50958346
121TIE10.48953930
122CSNK1A10.48034941
123CDC42BPA0.47878768
124PRKG10.47634044
125MAP3K120.47603746
126WEE10.47083774
127TEC0.46748809
128RPS6KL10.45429940
129RPS6KC10.45429940
130PRKCI0.45209162
131MAPKAPK30.44968517
132MAP2K40.44904530
133MAP2K20.44339655
134PIM10.44231905
135LRRK20.43729471
136CHEK20.43279106
137MAPKAPK50.43261452
138SIK30.42932619
139IKBKB0.42503889
140PLK20.42392667
141MINK10.41403763
142BCR0.38561557
143CDK80.38369273
144RPS6KA50.37161900
145CDK190.37047931
146AKT20.36995722
147PRKCA0.36019818
148MAP2K60.35250288
149BMPR20.34687309
150CAMK1G0.34084667
151STK110.28964474

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.26231875
2Parkinsons disease_Homo sapiens_hsa050125.11750365
3Alzheimers disease_Homo sapiens_hsa050104.23178669
4Huntingtons disease_Homo sapiens_hsa050163.79976533
5Cardiac muscle contraction_Homo sapiens_hsa042603.56542761
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.46717422
7Ribosome_Homo sapiens_hsa030103.34521332
8Nicotine addiction_Homo sapiens_hsa050332.38502407
9Phototransduction_Homo sapiens_hsa047441.82664593
10Taste transduction_Homo sapiens_hsa047421.70431118
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64677097
12Mismatch repair_Homo sapiens_hsa034301.55654770
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53888482
14Linoleic acid metabolism_Homo sapiens_hsa005911.46753149
15Serotonergic synapse_Homo sapiens_hsa047261.42303040
16Sulfur relay system_Homo sapiens_hsa041221.41508651
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39413678
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39406413
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39121100
20DNA replication_Homo sapiens_hsa030301.38955367
21Arachidonic acid metabolism_Homo sapiens_hsa005901.33227913
22Folate biosynthesis_Homo sapiens_hsa007901.27581826
23Collecting duct acid secretion_Homo sapiens_hsa049661.27247661
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22512401
25Glutamatergic synapse_Homo sapiens_hsa047241.22392324
26Fatty acid elongation_Homo sapiens_hsa000621.21822493
27Ether lipid metabolism_Homo sapiens_hsa005651.14164533
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13962533
29Sulfur metabolism_Homo sapiens_hsa009201.11377379
30Glutathione metabolism_Homo sapiens_hsa004801.07734455
31Nucleotide excision repair_Homo sapiens_hsa034201.06987917
32Protein export_Homo sapiens_hsa030601.06972729
33Calcium signaling pathway_Homo sapiens_hsa040201.06131255
34Morphine addiction_Homo sapiens_hsa050321.05895200
35Homologous recombination_Homo sapiens_hsa034401.05807894
36Sphingolipid metabolism_Homo sapiens_hsa006001.03345212
37Spliceosome_Homo sapiens_hsa030400.99012286
38Basal transcription factors_Homo sapiens_hsa030220.98619650
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98180810
40Fanconi anemia pathway_Homo sapiens_hsa034600.97665891
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96899100
42Pyruvate metabolism_Homo sapiens_hsa006200.96425001
43RNA polymerase_Homo sapiens_hsa030200.96039551
44Base excision repair_Homo sapiens_hsa034100.94844368
45RNA degradation_Homo sapiens_hsa030180.93804924
46GABAergic synapse_Homo sapiens_hsa047270.89392788
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87411196
48Tryptophan metabolism_Homo sapiens_hsa003800.83776671
49One carbon pool by folate_Homo sapiens_hsa006700.83748633
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83518736
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82337088
52Nitrogen metabolism_Homo sapiens_hsa009100.81000271
53Axon guidance_Homo sapiens_hsa043600.80379209
54Salivary secretion_Homo sapiens_hsa049700.78370079
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.78249232
56Circadian entrainment_Homo sapiens_hsa047130.77973752
57* Metabolic pathways_Homo sapiens_hsa011000.76353990
58Dilated cardiomyopathy_Homo sapiens_hsa054140.74683348
59Cocaine addiction_Homo sapiens_hsa050300.73445195
60Amphetamine addiction_Homo sapiens_hsa050310.73215019
61Propanoate metabolism_Homo sapiens_hsa006400.70698399
62Oxytocin signaling pathway_Homo sapiens_hsa049210.69640768
63Proteasome_Homo sapiens_hsa030500.69188173
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69098749
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67908520
66Histidine metabolism_Homo sapiens_hsa003400.67439882
67Chemical carcinogenesis_Homo sapiens_hsa052040.66401495
68Insulin secretion_Homo sapiens_hsa049110.66270357
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.65769476
70Rheumatoid arthritis_Homo sapiens_hsa053230.65765447
71Cholinergic synapse_Homo sapiens_hsa047250.63763059
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63415364
73Synaptic vesicle cycle_Homo sapiens_hsa047210.62457049
74Butanoate metabolism_Homo sapiens_hsa006500.61970048
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.60995622
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60117627
77Arginine and proline metabolism_Homo sapiens_hsa003300.59162554
78Vitamin digestion and absorption_Homo sapiens_hsa049770.58542504
79Pyrimidine metabolism_Homo sapiens_hsa002400.57343053
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.56585022
81Tyrosine metabolism_Homo sapiens_hsa003500.55724094
82RNA transport_Homo sapiens_hsa030130.55157235
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55037609
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.54616390
85Long-term depression_Homo sapiens_hsa047300.53843214
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53803114
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53034801
88Regulation of autophagy_Homo sapiens_hsa041400.52274977
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52266887
90beta-Alanine metabolism_Homo sapiens_hsa004100.52036025
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51729005
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51616412
93Pancreatic secretion_Homo sapiens_hsa049720.51519953
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50502928
95Alcoholism_Homo sapiens_hsa050340.50077370
96Asthma_Homo sapiens_hsa053100.49771217
97Dopaminergic synapse_Homo sapiens_hsa047280.49652824
98Caffeine metabolism_Homo sapiens_hsa002320.49265043
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48167075
100Fatty acid degradation_Homo sapiens_hsa000710.47938263
101Non-homologous end-joining_Homo sapiens_hsa034500.47759530
102African trypanosomiasis_Homo sapiens_hsa051430.46195542
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45905821
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45827389
105Vibrio cholerae infection_Homo sapiens_hsa051100.44996861
106Renin secretion_Homo sapiens_hsa049240.44764744
107Olfactory transduction_Homo sapiens_hsa047400.43883385
108Purine metabolism_Homo sapiens_hsa002300.43848534
109Ovarian steroidogenesis_Homo sapiens_hsa049130.43184697
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42758899
111Gastric acid secretion_Homo sapiens_hsa049710.42740124
112ABC transporters_Homo sapiens_hsa020100.42721572
113Mineral absorption_Homo sapiens_hsa049780.42048048
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41546539
115cAMP signaling pathway_Homo sapiens_hsa040240.40903265
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40897974
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.37194817
118Carbon metabolism_Homo sapiens_hsa012000.36868227
119Autoimmune thyroid disease_Homo sapiens_hsa053200.36776229
120Phenylalanine metabolism_Homo sapiens_hsa003600.36084437
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34802368
122Retinol metabolism_Homo sapiens_hsa008300.33878522
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33867658
124Type I diabetes mellitus_Homo sapiens_hsa049400.33350913
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32696449
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32310276
127Systemic lupus erythematosus_Homo sapiens_hsa053220.31952937
128Fatty acid metabolism_Homo sapiens_hsa012120.31645244
129Graft-versus-host disease_Homo sapiens_hsa053320.30465910
130Melanogenesis_Homo sapiens_hsa049160.30069857
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29410952
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28925464
133Selenocompound metabolism_Homo sapiens_hsa004500.27557311
134Steroid biosynthesis_Homo sapiens_hsa001000.25895981
135Vitamin B6 metabolism_Homo sapiens_hsa007500.25330342
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.25226457
137Peroxisome_Homo sapiens_hsa041460.24323565
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23660578
139Fat digestion and absorption_Homo sapiens_hsa049750.22769228
140Allograft rejection_Homo sapiens_hsa053300.20584152
141Primary immunodeficiency_Homo sapiens_hsa053400.19490988
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18257601

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