NDUFB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.41655341
2* respiratory electron transport chain (GO:0022904)8.85162206
3* electron transport chain (GO:0022900)8.63255108
4oxidative phosphorylation (GO:0006119)5.72569436
5ATP biosynthetic process (GO:0006754)5.66161390
6chaperone-mediated protein transport (GO:0072321)5.22888655
7hydrogen ion transmembrane transport (GO:1902600)5.22173762
8purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.19648082
9purine nucleoside triphosphate biosynthetic process (GO:0009145)5.11448473
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.00838110
11mitochondrial respiratory chain complex I assembly (GO:0032981)5.00838110
12NADH dehydrogenase complex assembly (GO:0010257)5.00838110
13protein complex biogenesis (GO:0070271)4.97845475
14inner mitochondrial membrane organization (GO:0007007)4.74386922
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.62825678
16proton transport (GO:0015992)4.60598884
17ribonucleoside triphosphate biosynthetic process (GO:0009201)4.56029584
18ribosomal small subunit assembly (GO:0000028)4.53898868
19hydrogen transport (GO:0006818)4.53162331
20mitochondrial respiratory chain complex assembly (GO:0033108)4.48088552
21protein neddylation (GO:0045116)4.11840580
22aerobic respiration (GO:0009060)3.97304103
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.92845713
24tricarboxylic acid cycle (GO:0006099)3.88552775
25nucleoside triphosphate biosynthetic process (GO:0009142)3.86021319
26termination of RNA polymerase III transcription (GO:0006386)3.79313441
27transcription elongation from RNA polymerase III promoter (GO:0006385)3.79313441
28sequestering of actin monomers (GO:0042989)3.70626499
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68755506
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66394537
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.60585248
32regulation of cellular amino acid metabolic process (GO:0006521)3.59847663
33ribosomal large subunit biogenesis (GO:0042273)3.59535745
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58610980
35GTP biosynthetic process (GO:0006183)3.56851507
36ribosomal small subunit biogenesis (GO:0042274)3.53871841
37regulation of mitochondrial translation (GO:0070129)3.53811748
38negative regulation of ligase activity (GO:0051352)3.53727898
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.53727898
40regulation of oxidative phosphorylation (GO:0002082)3.53252984
41regulation of acyl-CoA biosynthetic process (GO:0050812)3.53173102
42mitochondrial transport (GO:0006839)3.51699032
43cullin deneddylation (GO:0010388)3.50026845
44maturation of SSU-rRNA (GO:0030490)3.47370294
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46351967
46translational initiation (GO:0006413)3.42221525
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39338800
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37716294
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37716294
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37716294
51viral transcription (GO:0019083)3.36870208
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.35464677
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.35464677
54ubiquinone biosynthetic process (GO:0006744)3.33587514
55quinone biosynthetic process (GO:1901663)3.33587514
56chromatin remodeling at centromere (GO:0031055)3.32085088
57platelet dense granule organization (GO:0060155)3.31952407
58CENP-A containing nucleosome assembly (GO:0034080)3.31168691
59rRNA modification (GO:0000154)3.29588967
60ATP hydrolysis coupled proton transport (GO:0015991)3.29447648
61energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.29447648
62* generation of precursor metabolites and energy (GO:0006091)3.29297086
63translational termination (GO:0006415)3.22863598
64regulation of cofactor metabolic process (GO:0051193)3.22181665
65regulation of coenzyme metabolic process (GO:0051196)3.22181665
66nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21302283
67signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21139585
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.21139585
69signal transduction involved in cell cycle checkpoint (GO:0072395)3.20884848
70cellular respiration (GO:0045333)3.18383206
71ubiquinone metabolic process (GO:0006743)3.18200904
72cotranslational protein targeting to membrane (GO:0006613)3.16963906
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16896462
74protein deneddylation (GO:0000338)3.14993815
75respiratory chain complex IV assembly (GO:0008535)3.13879347
76negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.13573508
77water-soluble vitamin biosynthetic process (GO:0042364)3.13264436
78succinate metabolic process (GO:0006105)3.13137553
79regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.12916916
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12879886
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12879886
82purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.12307810
83purine nucleoside monophosphate biosynthetic process (GO:0009127)3.12307810
84protein targeting to mitochondrion (GO:0006626)3.10517055
85protein targeting to ER (GO:0045047)3.10088921
86substantia nigra development (GO:0021762)3.08914285
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06956202
88establishment of protein localization to mitochondrion (GO:0072655)3.03492556
89positive regulation of ligase activity (GO:0051351)3.02654235
90regulation of cellular respiration (GO:0043457)3.02208768
91NADH metabolic process (GO:0006734)3.02068548
92protein localization to endoplasmic reticulum (GO:0070972)3.00138614
93establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00068589
94spliceosomal snRNP assembly (GO:0000387)2.98993241
95protein localization to mitochondrion (GO:0070585)2.98638741
96axon ensheathment in central nervous system (GO:0032291)2.96996497
97central nervous system myelination (GO:0022010)2.96996497
98cytochrome complex assembly (GO:0017004)2.93659833
99protein targeting to membrane (GO:0006612)2.92809465
100calcium-mediated signaling using intracellular calcium source (GO:0035584)2.85781040
101purine nucleoside biosynthetic process (GO:0042451)2.84340476
102purine ribonucleoside biosynthetic process (GO:0046129)2.84340476
103protein complex disassembly (GO:0043241)2.83501449
104intracellular protein transmembrane import (GO:0044743)2.82320090
105organelle disassembly (GO:1903008)2.81337446
106establishment of integrated proviral latency (GO:0075713)2.81217054
107spliceosomal complex assembly (GO:0000245)2.81128922
108UTP biosynthetic process (GO:0006228)2.80827227
109cellular component biogenesis (GO:0044085)2.80079115
110fatty acid elongation (GO:0030497)2.79982541
111DNA damage response, detection of DNA damage (GO:0042769)2.79668174
112macromolecular complex disassembly (GO:0032984)2.78459768
1137-methylguanosine mRNA capping (GO:0006370)2.76249201
114regulation of ubiquitin-protein transferase activity (GO:0051438)2.72671806
115dopamine transport (GO:0015872)2.71987061
116aldehyde catabolic process (GO:0046185)2.71051145
117positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.69979591
118protein-cofactor linkage (GO:0018065)2.68459612
119heart contraction (GO:0060047)2.68080618
120heart process (GO:0003015)2.68080618
121regulation of cell communication by electrical coupling (GO:0010649)2.66888698
122regulation of sequestering of triglyceride (GO:0010889)2.64386377
123quinone metabolic process (GO:1901661)2.63628387
124sarcoplasmic reticulum calcium ion transport (GO:0070296)2.62342328
125regulation of catecholamine metabolic process (GO:0042069)2.61709645
126regulation of dopamine metabolic process (GO:0042053)2.61709645
127cellular protein complex disassembly (GO:0043624)2.55733692
128UTP metabolic process (GO:0046051)2.54208713
129translational elongation (GO:0006414)2.53975339
130positive regulation of action potential (GO:0045760)2.53158866
131mitochondrion morphogenesis (GO:0070584)2.52356093
132regulation of relaxation of muscle (GO:1901077)2.50626318
133viral life cycle (GO:0019058)2.50040897
134neuron cell-cell adhesion (GO:0007158)2.48937484
135guanosine-containing compound biosynthetic process (GO:1901070)2.48277763
136CTP biosynthetic process (GO:0006241)2.47517583
137CTP metabolic process (GO:0046036)2.47517583
138negative regulation of protein localization to cell surface (GO:2000009)2.42552516
139ribonucleoside monophosphate biosynthetic process (GO:0009156)2.42017848
140regulation of sulfur metabolic process (GO:0042762)2.40206124
141nucleoside diphosphate phosphorylation (GO:0006165)2.39761785
142proteasome assembly (GO:0043248)2.39529610
143response to epinephrine (GO:0071871)2.39095357
144detection of calcium ion (GO:0005513)2.39080920
145translation (GO:0006412)2.38797873
146long-chain fatty acid biosynthetic process (GO:0042759)2.34187682
147mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.7875444
148energy coupled proton transport, down electrochemical gradient (GO:0015985)10.3666086
149ATP synthesis coupled proton transport (GO:0015986)10.3666086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10667593
2EZH2_22144423_ChIP-Seq_EOC_Human3.51445667
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18047125
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09303768
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.03320270
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99799110
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.93878240
8VDR_22108803_ChIP-Seq_LS180_Human2.90302283
9* GABP_17652178_ChIP-ChIP_JURKAT_Human2.83785091
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61228205
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57029719
12TAF15_26573619_Chip-Seq_HEK293_Human2.53853623
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.46976354
14GBX2_23144817_ChIP-Seq_PC3_Human2.45201232
15* VDR_23849224_ChIP-Seq_CD4+_Human2.40227675
16* EST1_17652178_ChIP-ChIP_JURKAT_Human2.17363974
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16422783
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13335874
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08232346
20* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06928639
21* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99561003
22* FOXP3_21729870_ChIP-Seq_TREG_Human1.94307360
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90585246
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88808844
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88048719
26* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87124341
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86876520
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83864535
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.82132620
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80920539
31EWS_26573619_Chip-Seq_HEK293_Human1.80007207
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79188734
33MYC_18940864_ChIP-ChIP_HL60_Human1.76917650
34FUS_26573619_Chip-Seq_HEK293_Human1.74946605
35* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74924342
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69117362
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68427806
38* ETS1_20019798_ChIP-Seq_JURKAT_Human1.68062629
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67493385
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66074939
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.63295553
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60873234
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.60114304
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59793569
45TTF2_22483619_ChIP-Seq_HELA_Human1.59501925
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57604960
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57412719
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56490833
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.56345254
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54777433
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54700852
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54637331
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54423736
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53608466
55P300_19829295_ChIP-Seq_ESCs_Human1.47627517
56ER_23166858_ChIP-Seq_MCF-7_Human1.46701424
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45979720
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45333554
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40849235
60* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37804982
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37599656
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37599656
63* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34937891
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34850041
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34651234
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34353904
67* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32406117
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31753453
69GABP_19822575_ChIP-Seq_HepG2_Human1.31570197
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.31482717
71XRN2_22483619_ChIP-Seq_HELA_Human1.31182719
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30585693
73* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29678563
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28029911
75ZNF274_21170338_ChIP-Seq_K562_Hela1.27706540
76TP53_22573176_ChIP-Seq_HFKS_Human1.23844311
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23581445
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22328789
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22246143
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20730422
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.18896264
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17308214
83EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16133274
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14857107
85* REST_21632747_ChIP-Seq_MESCs_Mouse1.13390244
86HTT_18923047_ChIP-ChIP_STHdh_Human1.11761737
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.11323431
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10518922
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09877702
90IRF1_19129219_ChIP-ChIP_H3396_Human1.09389788
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.08671347
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07899933
93ELK1_22589737_ChIP-Seq_MCF10A_Human1.07796643
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07788794
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07495803
96DCP1A_22483619_ChIP-Seq_HELA_Human1.05859744
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.05598136
98* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05581465
99* NANOG_16153702_ChIP-ChIP_HESCs_Human1.05318969
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05232077
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.04027828
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04027828
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02758505
104* ELK1_19687146_ChIP-ChIP_HELA_Human1.01111753
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00781823
106* REST_18959480_ChIP-ChIP_MESCs_Mouse1.00675258
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99141819
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98991709
109THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98394615
110IGF1R_20145208_ChIP-Seq_DFB_Human0.97940472
111* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97049821
112AR_20517297_ChIP-Seq_VCAP_Human0.95636917
113* NFE2_27457419_Chip-Seq_LIVER_Mouse0.95196937
114SMAD3_21741376_ChIP-Seq_EPCs_Human0.94844455
115* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94307654
116* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93694837
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93408041
118NANOG_19829295_ChIP-Seq_ESCs_Human0.93279821
119SOX2_19829295_ChIP-Seq_ESCs_Human0.93279821
120* EZH2_27294783_Chip-Seq_NPCs_Mouse0.91463165
121ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91104871
122SMAD4_21799915_ChIP-Seq_A2780_Human0.90542576
123JUN_21703547_ChIP-Seq_K562_Human0.90087403
124GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86580238
125ERG_20517297_ChIP-Seq_VCAP_Human0.86216740
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86094959
127SALL4_22934838_ChIP-ChIP_CD34+_Human0.85531260
128RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85330578
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.84469746
130TAL1_26923725_Chip-Seq_HPCs_Mouse0.84247719
131BCAT_22108803_ChIP-Seq_LS180_Human0.84125082
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83314841
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82890449
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82585727
135CBP_20019798_ChIP-Seq_JUKART_Human0.82585727
136* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.82424519
137PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82418703
138RNF2_27304074_Chip-Seq_NSC_Mouse0.82142166
139CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81841498
140BP1_19119308_ChIP-ChIP_Hs578T_Human0.81428316
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81390895
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80659516
143* FLI1_27457419_Chip-Seq_LIVER_Mouse0.79878232
144NCOR_22424771_ChIP-Seq_293T_Human0.78722751
145DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76853748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.50818184
2MP0003880_abnormal_central_pattern3.71415361
3MP0003646_muscle_fatigue3.49738623
4MP0001529_abnormal_vocalization3.42056116
5MP0009379_abnormal_foot_pigmentation2.93686308
6MP0006036_abnormal_mitochondrial_physio2.89025026
7MP0006276_abnormal_autonomic_nervous2.53320051
8MP0004215_abnormal_myocardial_fiber2.51412820
9MP0000751_myopathy2.47816283
10MP0003011_delayed_dark_adaptation2.44595317
11MP0002938_white_spotting2.35419982
12MP0001905_abnormal_dopamine_level2.32014445
13MP0006292_abnormal_olfactory_placode2.24105394
14MP0004036_abnormal_muscle_relaxation2.23653152
15MP0005084_abnormal_gallbladder_morpholo2.18387782
16MP0008058_abnormal_DNA_repair2.13968460
17MP0005330_cardiomyopathy2.04552015
18MP0006035_abnormal_mitochondrial_morpho2.03266248
19MP0000749_muscle_degeneration2.02977748
20MP0004142_abnormal_muscle_tone1.98255897
21MP0004043_abnormal_pH_regulation1.91415492
22MP0002272_abnormal_nervous_system1.87605812
23MP0004145_abnormal_muscle_electrophysio1.86691015
24MP0004084_abnormal_cardiac_muscle1.85761918
25MP0009745_abnormal_behavioral_response1.85702082
26MP0001440_abnormal_grooming_behavior1.85324875
27MP0002822_catalepsy1.84604593
28MP0008877_abnormal_DNA_methylation1.81497181
29MP0005253_abnormal_eye_physiology1.79992277
30MP0002064_seizures1.78462335
31MP0002638_abnormal_pupillary_reflex1.72977514
32MP0009046_muscle_twitch1.65601542
33MP0001968_abnormal_touch/_nociception1.64474780
34MP0002102_abnormal_ear_morphology1.64122491
35MP0002735_abnormal_chemical_nociception1.63638298
36MP0002736_abnormal_nociception_after1.63500598
37MP0004484_altered_response_of1.62538117
38MP0003635_abnormal_synaptic_transmissio1.60043732
39MP0003137_abnormal_impulse_conducting1.59890604
40MP0004130_abnormal_muscle_cell1.58744174
41MP0002972_abnormal_cardiac_muscle1.56981632
42MP0004147_increased_porphyrin_level1.54714822
43MP0003195_calcinosis1.54486562
44MP0008995_early_reproductive_senescence1.53911919
45MP0008789_abnormal_olfactory_epithelium1.53660272
46MP0004270_analgesia1.52968746
47MP0005535_abnormal_body_temperature1.52475873
48MP0005386_behavior/neurological_phenoty1.49230301
49MP0004924_abnormal_behavior1.49230301
50MP0002572_abnormal_emotion/affect_behav1.48163538
51MP0001501_abnormal_sleep_pattern1.47076248
52MP0003718_maternal_effect1.45844836
53MP0002277_abnormal_respiratory_mucosa1.44432055
54MP0005620_abnormal_muscle_contractility1.43608979
55MP0009697_abnormal_copulation1.42180773
56MP0002332_abnormal_exercise_endurance1.42172078
57MP0002734_abnormal_mechanical_nocicepti1.40841596
58MP0002234_abnormal_pharynx_morphology1.38768034
59MP0003136_yellow_coat_color1.37862182
60MP0003121_genomic_imprinting1.37588375
61MP0003122_maternal_imprinting1.36985407
62MP0001486_abnormal_startle_reflex1.34257026
63MP0000631_abnormal_neuroendocrine_gland1.33896292
64MP0001970_abnormal_pain_threshold1.33606063
65MP0003329_amyloid_beta_deposits1.28052434
66MP0004085_abnormal_heartbeat1.26764557
67MP0004957_abnormal_blastocyst_morpholog1.26721391
68MP0003786_premature_aging1.26349859
69MP0000013_abnormal_adipose_tissue1.26217776
70MP0004133_heterotaxia1.24335063
71MP0002063_abnormal_learning/memory/cond1.23406408
72MP0002733_abnormal_thermal_nociception1.23399227
73MP0002067_abnormal_sensory_capabilities1.23219627
74MP0008775_abnormal_heart_ventricle1.22358347
75MP0001293_anophthalmia1.20233032
76MP0003787_abnormal_imprinting1.20054930
77MP0002106_abnormal_muscle_physiology1.19651219
78MP0005423_abnormal_somatic_nervous1.18567275
79MP0001984_abnormal_olfaction1.18204351
80MP0005646_abnormal_pituitary_gland1.18185909
81MP0005409_darkened_coat_color1.17742237
82MP0010094_abnormal_chromosome_stability1.17175983
83MP0005379_endocrine/exocrine_gland_phen1.17057165
84MP0002090_abnormal_vision1.16752100
85MP0010386_abnormal_urinary_bladder1.16163969
86MP0003950_abnormal_plasma_membrane1.15766925
87MP0001727_abnormal_embryo_implantation1.13813460
88MP0000920_abnormal_myelination1.12646608
89MP0005408_hypopigmentation1.11744712
90MP0003186_abnormal_redox_activity1.11154170
91MP0001764_abnormal_homeostasis1.11068306
92MP0002876_abnormal_thyroid_physiology1.09901407
93MP0001544_abnormal_cardiovascular_syste1.09613399
94MP0005385_cardiovascular_system_phenoty1.09613399
95MP0003806_abnormal_nucleotide_metabolis1.07403132
96MP0008872_abnormal_physiological_respon1.06620532
97MP0006138_congestive_heart_failure1.05729282
98MP0002095_abnormal_skin_pigmentation1.03966323
99MP0000747_muscle_weakness1.03956900
100MP0002163_abnormal_gland_morphology1.03682644
101MP0004859_abnormal_synaptic_plasticity1.01823664
102MP0006072_abnormal_retinal_apoptosis1.01642350
103MP0000750_abnormal_muscle_regeneration1.01436590
104MP0002751_abnormal_autonomic_nervous1.00020749
105MP0000230_abnormal_systemic_arterial0.99565732
106MP0005075_abnormal_melanosome_morpholog0.98820182
107MP0005369_muscle_phenotype0.98293955
108MP0003693_abnormal_embryo_hatching0.95339239
109MP0005645_abnormal_hypothalamus_physiol0.94387187
110MP0004087_abnormal_muscle_fiber0.93610442
111MP0005551_abnormal_eye_electrophysiolog0.93328388
112MP0002653_abnormal_ependyma_morphology0.92196601
113MP0005499_abnormal_olfactory_system0.92038617
114MP0005394_taste/olfaction_phenotype0.92038617
115MP0003283_abnormal_digestive_organ0.91414194
116MP0004885_abnormal_endolymph0.90678809
117MP0008932_abnormal_embryonic_tissue0.90203696
118MP0008875_abnormal_xenobiotic_pharmacok0.89523283
119MP0002229_neurodegeneration0.89369599
120MP0000372_irregular_coat_pigmentation0.89337052
121MP0010030_abnormal_orbit_morphology0.89166207
122MP0002210_abnormal_sex_determination0.89087810
123MP0002971_abnormal_brown_adipose0.88324758
124MP0000759_abnormal_skeletal_muscle0.88254851
125MP0004742_abnormal_vestibular_system0.87497177
126MP0002184_abnormal_innervation0.87285402
127MP0005332_abnormal_amino_acid0.87112123
128MP0002160_abnormal_reproductive_system0.86952902
129MP0001188_hyperpigmentation0.86918737
130MP0005266_abnormal_metabolism0.86850332
131MP0005171_absent_coat_pigmentation0.86479666
132MP0005165_increased_susceptibility_to0.86434790
133MP0002066_abnormal_motor_capabilities/c0.86056280
134MP0001986_abnormal_taste_sensitivity0.84952033
135MP0005195_abnormal_posterior_eye0.83402643
136MP0004019_abnormal_vitamin_homeostasis0.82941344
137MP0001485_abnormal_pinna_reflex0.82938973
138MP0003315_abnormal_perineum_morphology0.82325579
139MP0000026_abnormal_inner_ear0.80831987
140MP0005389_reproductive_system_phenotype0.80812345
141MP0000647_abnormal_sebaceous_gland0.80638607
142MP0005636_abnormal_mineral_homeostasis0.80183040
143MP0005666_abnormal_adipose_tissue0.78333700
144MP0000778_abnormal_nervous_system0.76154626
145MP0005391_vision/eye_phenotype0.75594365
146MP0004185_abnormal_adipocyte_glucose0.75392310
147MP0002909_abnormal_adrenal_gland0.75168044
148MP0001929_abnormal_gametogenesis0.74305493
149MP0002557_abnormal_social/conspecific_i0.74265903
150MP0003567_abnormal_fetal_cardiomyocyte0.73784085
151MP0002752_abnormal_somatic_nervous0.73031324
152MP0000653_abnormal_sex_gland0.72534993
153MP0003221_abnormal_cardiomyocyte_apopto0.71412254

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)7.63716519
2* Abnormal mitochondria in muscle tissue (HP:0008316)6.98777602
3* Acute encephalopathy (HP:0006846)6.44904929
4* Progressive macrocephaly (HP:0004481)6.41079300
5* Mitochondrial inheritance (HP:0001427)6.39028750
6Hepatocellular necrosis (HP:0001404)5.57828162
7* Increased CSF lactate (HP:0002490)5.48038205
8Hepatic necrosis (HP:0002605)5.37381064
9Increased hepatocellular lipid droplets (HP:0006565)4.94146382
10* Cerebral edema (HP:0002181)4.74852491
11Lipid accumulation in hepatocytes (HP:0006561)4.71000563
12Abnormality of glycolysis (HP:0004366)4.35281701
13Increased serum pyruvate (HP:0003542)4.35281701
14Renal Fanconi syndrome (HP:0001994)4.15604760
15Increased intramyocellular lipid droplets (HP:0012240)4.10668467
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.09237709
17* Lactic acidosis (HP:0003128)4.04452079
18* Optic disc pallor (HP:0000543)3.99087908
19* Respiratory failure (HP:0002878)3.96608616
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.95758036
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.95758036
22* Exercise intolerance (HP:0003546)3.90256338
23Increased muscle lipid content (HP:0009058)3.83523045
24* Leukodystrophy (HP:0002415)3.71547454
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.58493980
263-Methylglutaconic aciduria (HP:0003535)3.36530902
27Increased serum lactate (HP:0002151)3.34766845
28Congenital, generalized hypertrichosis (HP:0004540)3.26493055
29Muscle hypertrophy of the lower extremities (HP:0008968)3.16110653
30Neuroendocrine neoplasm (HP:0100634)3.13241409
31Pheochromocytoma (HP:0002666)3.08865514
32Calf muscle hypertrophy (HP:0008981)3.04438950
33Exertional dyspnea (HP:0002875)2.95633355
34Reticulocytopenia (HP:0001896)2.93414937
35* X-linked dominant inheritance (HP:0001423)2.77150211
36Respiratory difficulties (HP:0002880)2.74699078
37Abnormality of renal resorption (HP:0011038)2.74081488
38Palpitations (HP:0001962)2.73160731
39Abnormality of midbrain morphology (HP:0002418)2.69972960
40Molar tooth sign on MRI (HP:0002419)2.69972960
41Pancreatic fibrosis (HP:0100732)2.67710958
42Sudden death (HP:0001699)2.63274667
43Abnormality of cells of the erythroid lineage (HP:0012130)2.60866197
44Pancreatic cysts (HP:0001737)2.57990100
45Glycosuria (HP:0003076)2.54699538
46Abnormality of urine glucose concentration (HP:0011016)2.54699538
47True hermaphroditism (HP:0010459)2.54036988
48* Lethargy (HP:0001254)2.51892277
49CNS demyelination (HP:0007305)2.47613175
50Dicarboxylic aciduria (HP:0003215)2.47010958
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47010958
52Methylmalonic acidemia (HP:0002912)2.36636912
53Methylmalonic aciduria (HP:0012120)2.36198205
54Parakeratosis (HP:0001036)2.33889468
55Nephronophthisis (HP:0000090)2.32303871
56Abnormality of alanine metabolism (HP:0010916)2.31231473
57Hyperalaninemia (HP:0003348)2.31231473
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31231473
59Conjunctival hamartoma (HP:0100780)2.29469356
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.28587562
61Abnormal number of erythroid precursors (HP:0012131)2.28570513
62Type I transferrin isoform profile (HP:0003642)2.28534109
63Progressive inability to walk (HP:0002505)2.25250521
64Focal motor seizures (HP:0011153)2.24689934
65Emotional lability (HP:0000712)2.23625779
66Generalized aminoaciduria (HP:0002909)2.23293302
67Myokymia (HP:0002411)2.21676651
68Exercise-induced myalgia (HP:0003738)2.20576789
69Hypothermia (HP:0002045)2.18302389
70Hyperphosphaturia (HP:0003109)2.18139180
71Hyperglycinemia (HP:0002154)2.16642014
72Degeneration of anterior horn cells (HP:0002398)2.15013989
73Abnormality of the anterior horn cell (HP:0006802)2.15013989
74Myoglobinuria (HP:0002913)2.12918018
75Cerebral hemorrhage (HP:0001342)2.10211115
76Abnormality of the calf musculature (HP:0001430)2.07455323
77* Vomiting (HP:0002013)2.07283631
78Colon cancer (HP:0003003)2.05400833
79Septo-optic dysplasia (HP:0100842)2.05059627
80Ragged-red muscle fibers (HP:0003200)2.01755573
81Microvesicular hepatic steatosis (HP:0001414)1.98440447
82Congenital primary aphakia (HP:0007707)1.97997769
83Sclerocornea (HP:0000647)1.96660836
84Gait imbalance (HP:0002141)1.95717642
85Abnormality of the labia minora (HP:0012880)1.94625391
86Ventricular tachycardia (HP:0004756)1.94337990
87Abnormality of placental membranes (HP:0011409)1.93942296
88Amniotic constriction ring (HP:0009775)1.93942296
89Aplastic anemia (HP:0001915)1.92637429
90Pallor (HP:0000980)1.92386532
91Abnormal urine phosphate concentration (HP:0012599)1.91120824
92Gliosis (HP:0002171)1.87279171
93Abnormality of fatty-acid metabolism (HP:0004359)1.85341977
94Muscle fiber splitting (HP:0003555)1.84637557
95Muscle stiffness (HP:0003552)1.81865598
96Renal cortical cysts (HP:0000803)1.81586352
97Rhabdomyolysis (HP:0003201)1.80976822
98Ketoacidosis (HP:0001993)1.79731775
99Abnormality of the renal medulla (HP:0100957)1.79562748
100Hyperglycinuria (HP:0003108)1.79538905
101Abnormality of methionine metabolism (HP:0010901)1.79241048
102Oral leukoplakia (HP:0002745)1.79049192
103Hyperventilation (HP:0002883)1.78560071
104Nephrogenic diabetes insipidus (HP:0009806)1.77501235
105Anxiety (HP:0000739)1.77275385
106Myotonia (HP:0002486)1.77268386
107Hypoglycemic coma (HP:0001325)1.75475914
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75194209
109Abnormality of serum amino acid levels (HP:0003112)1.74672550
110Renal tubular dysfunction (HP:0000124)1.72897890
111Syncope (HP:0001279)1.72574136
112Male pseudohermaphroditism (HP:0000037)1.71890257
113Macrocytic anemia (HP:0001972)1.70785729
114Progressive external ophthalmoplegia (HP:0000590)1.70536324
115Retinal dysplasia (HP:0007973)1.70458336
116Aplasia/hypoplasia of the uterus (HP:0008684)1.69928524
117Atrial fibrillation (HP:0005110)1.69759744
118Abnormality of the renal cortex (HP:0011035)1.68459766
119Congenital stationary night blindness (HP:0007642)1.68005281
120Abnormal protein glycosylation (HP:0012346)1.67910950
121Abnormal glycosylation (HP:0012345)1.67910950
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67910950
123Abnormal protein N-linked glycosylation (HP:0012347)1.67910950
124Lipoatrophy (HP:0100578)1.67209496
125Exercise-induced muscle cramps (HP:0003710)1.67138050
126Abnormality of vitamin B metabolism (HP:0004340)1.65804099
127Supraventricular tachycardia (HP:0004755)1.64582775
128Large for gestational age (HP:0001520)1.64232605
129Medial flaring of the eyebrow (HP:0010747)1.63955161
130Prolonged QT interval (HP:0001657)1.63859953
131Metabolic acidosis (HP:0001942)1.63458800
132Primary atrial arrhythmia (HP:0001692)1.62690369
133Neoplasm of head and neck (HP:0012288)1.62624418
134Esophageal neoplasm (HP:0100751)1.62624418
135Genital tract atresia (HP:0001827)1.62472256
136Nemaline bodies (HP:0003798)1.61442053
137Sensory axonal neuropathy (HP:0003390)1.61230295
138Abnormal pupillary function (HP:0007686)1.61136486
139Limb dystonia (HP:0002451)1.60921607
140Absent septum pellucidum (HP:0001331)1.60839189
141Degeneration of the lateral corticospinal tracts (HP:0002314)1.60509345
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.60509345
143Supraventricular arrhythmia (HP:0005115)1.57178035
144Atonic seizures (HP:0010819)1.56860358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.22854755
2NME23.80910707
3MAP3K123.06189911
4MYLK2.94286173
5STK392.89373242
6GRK72.86844372
7NME12.79877754
8MST42.72799604
9BUB12.64611634
10ARAF2.58113718
11MUSK2.49856378
12CASK2.36071020
13ZAK2.34265307
14WNK42.24608138
15PNCK2.11256315
16OXSR12.04262691
17NEK12.00093195
18GRK51.91633506
19STK161.90393405
20OBSCN1.89584331
21MAP4K21.81843650
22BCKDK1.81429194
23TRIM281.78951439
24CDC71.72947899
25MAP2K71.72343401
26NUAK11.65774494
27CDK191.59038699
28TNIK1.58920124
29NTRK31.57262726
30WEE11.53130204
31PLK31.52342738
32EPHA41.50813768
33SRPK11.49337363
34PDK31.41527339
35PDK41.41527339
36PHKG21.41256910
37PHKG11.41256910
38MAPKAPK51.39911200
39CAMK2D1.39699513
40MAP3K41.33632788
41PLK41.31649727
42GRK11.29949674
43FRK1.29776634
44PBK1.27952358
45RIPK41.27249245
46CAMK2A1.25176348
47INSRR1.22684215
48CAMK2B1.22662687
49TAF11.21400333
50ADRBK21.20835809
51LIMK11.19836145
52BMPR21.16415212
53BCR1.16004637
54PINK11.14128998
55TLK11.14095347
56ERBB31.09837827
57CCNB11.08130210
58PKN11.07369690
59CAMK2G1.05479347
60BMPR1B1.03190879
61MAP2K41.03027383
62PIK3CA1.01875254
63BRSK21.00358717
64FGR1.00085741
65PLK20.99947359
66UHMK10.99086222
67MAPK130.97530847
68MKNK10.96686225
69ADRBK10.94524039
70VRK10.92201435
71DYRK30.89467710
72ACVR1B0.87262349
73TTK0.86375725
74PRKCE0.86337567
75MKNK20.86307403
76DAPK30.85610581
77MINK10.85394489
78PDK20.84930956
79ILK0.83895743
80PLK10.83325363
81PASK0.83152112
82ABL20.82591390
83DYRK20.82197562
84PTK2B0.81087076
85ROCK20.79253184
86PAK30.77903251
87TSSK60.75048965
88TTN0.73828404
89MAPK150.73118039
90PRKACA0.72991859
91BRAF0.72756712
92CSNK1A1L0.71742196
93CSNK1G30.68125863
94LMTK20.66269492
95PIK3CG0.65125452
96MARK10.64907923
97AURKB0.60931222
98CSNK2A20.59373633
99CSNK2A10.58991498
100NTRK10.58984985
101IRAK10.58794543
102WNK30.56858079
103EPHB20.56397200
104PIM20.56303154
105STK240.55829364
106MAPK120.55790102
107GRK60.55723685
108CDK80.53618486
109RPS6KA50.52160642
110PRKCQ0.51928665
111WNK10.51463906
112CDK50.50755562
113EIF2AK20.50326079
114CAMK10.48610518
115CAMKK20.48448365
116EIF2AK30.46589402
117CHEK20.44978434
118MOS0.43949734
119PRKCG0.43752809
120CSNK1G20.43394020
121STK40.42892520
122RAF10.41561067
123FES0.41527558
124IRAK20.40719476
125CSNK1A10.39842406
126BRSK10.38853942
127PRKG10.38643678
128MAPK40.38358826
129IRAK30.37917815
130STK38L0.37267303
131CDK140.36204409
132ATR0.36131332
133PRKD10.35939833
134EIF2AK10.35147207
135DAPK10.34530040
136TIE10.33157555
137KDR0.33127708
138AURKA0.32595920
139PRKCA0.31748783
140MAP2K10.30729113
141DYRK1A0.29541981
142PRKACG0.29536765
143PRKACB0.29389825
144CSNK1G10.28351946

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.63799662
2Parkinsons disease_Homo sapiens_hsa050125.69706360
3Alzheimers disease_Homo sapiens_hsa050104.47715971
4Huntingtons disease_Homo sapiens_hsa050163.96344717
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.71800534
6Cardiac muscle contraction_Homo sapiens_hsa042603.45263831
7Ribosome_Homo sapiens_hsa030102.91244294
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.83782201
9Protein export_Homo sapiens_hsa030602.18831825
10Proteasome_Homo sapiens_hsa030502.12370116
11Fatty acid elongation_Homo sapiens_hsa000622.12334036
12Propanoate metabolism_Homo sapiens_hsa006402.11318250
13Mismatch repair_Homo sapiens_hsa034302.08474044
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06070264
15Sulfur metabolism_Homo sapiens_hsa009202.00009425
16Homologous recombination_Homo sapiens_hsa034401.92400619
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65752027
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62020676
19DNA replication_Homo sapiens_hsa030301.60987475
20Collecting duct acid secretion_Homo sapiens_hsa049661.58251332
21Pyruvate metabolism_Homo sapiens_hsa006201.56776025
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56291161
23Nucleotide excision repair_Homo sapiens_hsa034201.40339506
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33258097
25Spliceosome_Homo sapiens_hsa030401.33017066
26Basal transcription factors_Homo sapiens_hsa030221.31606963
27Butanoate metabolism_Homo sapiens_hsa006501.31532144
28RNA degradation_Homo sapiens_hsa030181.26284751
29Nicotine addiction_Homo sapiens_hsa050331.21445406
30RNA polymerase_Homo sapiens_hsa030201.19247850
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.18596735
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18416023
33Fanconi anemia pathway_Homo sapiens_hsa034601.16814219
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14333728
35One carbon pool by folate_Homo sapiens_hsa006701.04676858
36Carbon metabolism_Homo sapiens_hsa012001.02734268
37Fatty acid degradation_Homo sapiens_hsa000710.94438112
38Vibrio cholerae infection_Homo sapiens_hsa051100.94411095
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89238154
40Peroxisome_Homo sapiens_hsa041460.88480310
41Fatty acid metabolism_Homo sapiens_hsa012120.88456044
42* Metabolic pathways_Homo sapiens_hsa011000.88082355
43Phenylalanine metabolism_Homo sapiens_hsa003600.86352467
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86199169
45Nitrogen metabolism_Homo sapiens_hsa009100.85211272
46RNA transport_Homo sapiens_hsa030130.84831633
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84373025
48Serotonergic synapse_Homo sapiens_hsa047260.83594422
49Base excision repair_Homo sapiens_hsa034100.82980350
50Tyrosine metabolism_Homo sapiens_hsa003500.82051346
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81306271
52Non-homologous end-joining_Homo sapiens_hsa034500.80132005
53GABAergic synapse_Homo sapiens_hsa047270.75967475
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74195474
55Taste transduction_Homo sapiens_hsa047420.72888841
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.69960708
57Caffeine metabolism_Homo sapiens_hsa002320.69316742
58Ether lipid metabolism_Homo sapiens_hsa005650.68952949
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65056599
60Histidine metabolism_Homo sapiens_hsa003400.64799503
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64718752
62Linoleic acid metabolism_Homo sapiens_hsa005910.64346717
63Glutathione metabolism_Homo sapiens_hsa004800.63794230
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62748170
65beta-Alanine metabolism_Homo sapiens_hsa004100.62716927
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62395026
67Steroid biosynthesis_Homo sapiens_hsa001000.62116666
68Synaptic vesicle cycle_Homo sapiens_hsa047210.61881037
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59929802
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59027896
71Morphine addiction_Homo sapiens_hsa050320.58662928
72Arginine and proline metabolism_Homo sapiens_hsa003300.55472417
73Arachidonic acid metabolism_Homo sapiens_hsa005900.55095040
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54573441
75Phototransduction_Homo sapiens_hsa047440.51199911
76Circadian entrainment_Homo sapiens_hsa047130.51070624
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50339191
78PPAR signaling pathway_Homo sapiens_hsa033200.50225390
79Dilated cardiomyopathy_Homo sapiens_hsa054140.50140300
80Glutamatergic synapse_Homo sapiens_hsa047240.49645957
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48457997
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48194943
83Rheumatoid arthritis_Homo sapiens_hsa053230.47763325
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47398537
85Calcium signaling pathway_Homo sapiens_hsa040200.47115549
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45514951
87Retinol metabolism_Homo sapiens_hsa008300.44436680
88Pyrimidine metabolism_Homo sapiens_hsa002400.42593569
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42461122
90Renin secretion_Homo sapiens_hsa049240.41995467
91Chemical carcinogenesis_Homo sapiens_hsa052040.41349589
92Amphetamine addiction_Homo sapiens_hsa050310.40995814
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38955730
94Dopaminergic synapse_Homo sapiens_hsa047280.38679566
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38022852
96Selenocompound metabolism_Homo sapiens_hsa004500.36693546
97Mineral absorption_Homo sapiens_hsa049780.34302013
98Purine metabolism_Homo sapiens_hsa002300.33826233
99Salivary secretion_Homo sapiens_hsa049700.32897680
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32895659
101Folate biosynthesis_Homo sapiens_hsa007900.32578274
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32007034
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31530756
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.31191383
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.30803273
106Oocyte meiosis_Homo sapiens_hsa041140.30277776
107Tryptophan metabolism_Homo sapiens_hsa003800.29953163
108Cell cycle_Homo sapiens_hsa041100.29650210
109Cholinergic synapse_Homo sapiens_hsa047250.27688848
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26258469
111Systemic lupus erythematosus_Homo sapiens_hsa053220.26046593
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.25424700
113Regulation of autophagy_Homo sapiens_hsa041400.24556856
114Long-term potentiation_Homo sapiens_hsa047200.24499646
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24442917
116Vitamin digestion and absorption_Homo sapiens_hsa049770.24298605
117Long-term depression_Homo sapiens_hsa047300.24076457
118Sulfur relay system_Homo sapiens_hsa041220.23664026
119Olfactory transduction_Homo sapiens_hsa047400.23225229
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22625904
121Asthma_Homo sapiens_hsa053100.22462835
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22292683
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.21410806
124Phagosome_Homo sapiens_hsa041450.21336623
125N-Glycan biosynthesis_Homo sapiens_hsa005100.21101521
126Gastric acid secretion_Homo sapiens_hsa049710.21079134
127Oxytocin signaling pathway_Homo sapiens_hsa049210.19070688
128Insulin secretion_Homo sapiens_hsa049110.18783396
129Cocaine addiction_Homo sapiens_hsa050300.16837110
130Sphingolipid metabolism_Homo sapiens_hsa006000.14557982
131Pancreatic secretion_Homo sapiens_hsa049720.10290759
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.08076702
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.07780726
134Fat digestion and absorption_Homo sapiens_hsa049750.07759499
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07737973
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05853396
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.04689676

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