NDUFB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.29480919
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.85472580
3ATP synthesis coupled proton transport (GO:0015986)8.85472580
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.44648617
5* respiratory electron transport chain (GO:0022904)7.51135314
6* electron transport chain (GO:0022900)7.33463870
7ribosomal small subunit assembly (GO:0000028)5.69140322
8protein neddylation (GO:0045116)5.45957185
9chaperone-mediated protein transport (GO:0072321)5.25337012
10establishment of protein localization to mitochondrial membrane (GO:0090151)5.23331612
11axon ensheathment in central nervous system (GO:0032291)5.21148758
12central nervous system myelination (GO:0022010)5.21148758
13maturation of SSU-rRNA (GO:0030490)4.87012469
14protein complex biogenesis (GO:0070271)4.80659766
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.74657977
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.74657977
17NADH dehydrogenase complex assembly (GO:0010257)4.74657977
18hydrogen ion transmembrane transport (GO:1902600)4.70704193
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.68885749
20ATP biosynthetic process (GO:0006754)4.64907230
21translational initiation (GO:0006413)4.63495312
22purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.54196746
23purine nucleoside triphosphate biosynthetic process (GO:0009145)4.45934015
24ribosomal large subunit biogenesis (GO:0042273)4.40844256
25mitochondrial respiratory chain complex assembly (GO:0033108)4.31060255
26inner mitochondrial membrane organization (GO:0007007)4.24693300
27fatty acid elongation (GO:0030497)4.23579474
28proton transport (GO:0015992)4.21499263
29GTP biosynthetic process (GO:0006183)4.16710053
30hydrogen transport (GO:0006818)4.13071963
31ribosomal small subunit biogenesis (GO:0042274)4.12299366
32protein complex disassembly (GO:0043241)4.08814984
33macromolecular complex disassembly (GO:0032984)3.92725587
34ribonucleoside triphosphate biosynthetic process (GO:0009201)3.89682015
35protein targeting to membrane (GO:0006612)3.87179998
36long-chain fatty acid biosynthetic process (GO:0042759)3.79345687
37viral transcription (GO:0019083)3.64925287
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58977776
39cellular component biogenesis (GO:0044085)3.57880597
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54855965
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54783265
42nuclear-transcribed mRNA catabolic process (GO:0000956)3.49909038
43water-soluble vitamin biosynthetic process (GO:0042364)3.48165841
44translational termination (GO:0006415)3.47440534
45dopamine transport (GO:0015872)3.46189502
46substantia nigra development (GO:0021762)3.44785198
47cotranslational protein targeting to membrane (GO:0006613)3.41839888
48spliceosomal snRNP assembly (GO:0000387)3.39674833
49chromatin remodeling at centromere (GO:0031055)3.35983006
50rRNA modification (GO:0000154)3.35168676
51protein targeting to ER (GO:0045047)3.33464992
52ATP hydrolysis coupled proton transport (GO:0015991)3.32074478
53energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.32074478
54neuron cell-cell adhesion (GO:0007158)3.32057345
55UTP biosynthetic process (GO:0006228)3.31537510
56mRNA catabolic process (GO:0006402)3.29843210
57presynaptic membrane assembly (GO:0097105)3.29140652
58nucleoside triphosphate biosynthetic process (GO:0009142)3.27791691
59CENP-A containing nucleosome assembly (GO:0034080)3.27205399
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24292467
61ribonucleoprotein complex biogenesis (GO:0022613)3.24021685
62oxidative phosphorylation (GO:0006119)3.23643517
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22350309
64protein localization to endoplasmic reticulum (GO:0070972)3.22225474
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21489827
66dopamine biosynthetic process (GO:0042416)3.20964689
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20209060
68negative regulation of ligase activity (GO:0051352)3.19920264
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.19920264
70pseudouridine synthesis (GO:0001522)3.19151211
71regulation of mitochondrial translation (GO:0070129)3.18802674
72purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.17794061
73purine nucleoside monophosphate biosynthetic process (GO:0009127)3.17794061
74presynaptic membrane organization (GO:0097090)3.16613867
75regulation of dopamine metabolic process (GO:0042053)3.13247354
76regulation of catecholamine metabolic process (GO:0042069)3.13247354
77protein targeting to mitochondrion (GO:0006626)3.12092273
78protein-cofactor linkage (GO:0018065)3.11852971
79DNA damage response, detection of DNA damage (GO:0042769)3.10874399
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04108324
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04108324
82establishment of protein localization to mitochondrion (GO:0072655)3.03382160
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00624656
84RNA catabolic process (GO:0006401)2.98835736
85mitochondrial transport (GO:0006839)2.97700539
86regulation of cellular amino acid metabolic process (GO:0006521)2.97617630
87establishment of integrated proviral latency (GO:0075713)2.97403020
88rRNA processing (GO:0006364)2.96914572
89intracellular protein transmembrane import (GO:0044743)2.95894923
90protein localization to mitochondrion (GO:0070585)2.90867721
91respiratory chain complex IV assembly (GO:0008535)2.90317968
92spliceosomal complex assembly (GO:0000245)2.90041167
93sequestering of actin monomers (GO:0042989)2.88679076
94protein targeting (GO:0006605)2.88077152
95UTP metabolic process (GO:0046051)2.87816614
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87183568
97intracellular protein transmembrane transport (GO:0065002)2.86757984
98rRNA metabolic process (GO:0016072)2.86405931
99RNA capping (GO:0036260)2.84094643
1007-methylguanosine RNA capping (GO:0009452)2.84094643
101neurotransmitter uptake (GO:0001504)2.82129706
102proteasome assembly (GO:0043248)2.81861334
103cellular protein complex disassembly (GO:0043624)2.81775385
104protein transmembrane transport (GO:0071806)2.81173868
105regulation of oxidative phosphorylation (GO:0002082)2.80269714
106signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80094881
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80094881
108signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80094881
109pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79841938
110negative regulation of neurotransmitter transport (GO:0051589)2.79270994
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78268804
1127-methylguanosine mRNA capping (GO:0006370)2.78230958
113viral life cycle (GO:0019058)2.76631029
114aerobic respiration (GO:0009060)2.75121172
115nucleoside diphosphate phosphorylation (GO:0006165)2.74275479
116negative regulation of protein localization to cell surface (GO:2000009)2.69854603
117GPI anchor biosynthetic process (GO:0006506)2.68594348
118calcium-mediated signaling using intracellular calcium source (GO:0035584)2.68052680
119regulation of protein kinase A signaling (GO:0010738)2.67470530
120CTP biosynthetic process (GO:0006241)2.66609689
121CTP metabolic process (GO:0046036)2.66609689
122guanosine-containing compound biosynthetic process (GO:1901070)2.65882522
123translational elongation (GO:0006414)2.64500756
124regulation of glutamate secretion (GO:0014048)2.62027941
125cholesterol biosynthetic process (GO:0006695)2.60486896
126cytochrome complex assembly (GO:0017004)2.59847710
127negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.58771202
128positive regulation of synapse assembly (GO:0051965)2.58714693
129positive regulation of action potential (GO:0045760)2.56979879
130* generation of precursor metabolites and energy (GO:0006091)2.52639137
131cullin deneddylation (GO:0010388)2.52560542
132GPI anchor metabolic process (GO:0006505)2.50272559
133myelination (GO:0042552)2.49193820
134neuronal action potential propagation (GO:0019227)2.47095095
135quinone biosynthetic process (GO:1901663)2.46428174
136ubiquinone biosynthetic process (GO:0006744)2.46428174
137ubiquinone metabolic process (GO:0006743)2.46050801
138mitochondrion morphogenesis (GO:0070584)2.46016259
139response to epinephrine (GO:0071871)2.44390002
140translation (GO:0006412)2.44068454
141axon ensheathment (GO:0008366)2.43603350
142ensheathment of neurons (GO:0007272)2.43603350
143mannosylation (GO:0097502)2.43232561
144neural nucleus development (GO:0048857)2.43229882
145termination of RNA polymerase III transcription (GO:0006386)2.42403679
146transcription elongation from RNA polymerase III promoter (GO:0006385)2.42403679
147aldehyde catabolic process (GO:0046185)2.37486869
148regulation of cellular respiration (GO:0043457)2.36976363
149positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.36122597
150protein localization to cilium (GO:0061512)2.36038420
151cellular response to epinephrine stimulus (GO:0071872)2.36006285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33936557
2EZH2_22144423_ChIP-Seq_EOC_Human3.68103229
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.55443726
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.05137627
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90110294
6TAF15_26573619_Chip-Seq_HEK293_Human2.89045521
7GBX2_23144817_ChIP-Seq_PC3_Human2.82147590
8ELK1_19687146_ChIP-ChIP_HELA_Human2.75534738
9VDR_22108803_ChIP-Seq_LS180_Human2.70792764
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61899949
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52416878
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.35422282
13VDR_23849224_ChIP-Seq_CD4+_Human2.31039814
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29817408
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27277439
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23044388
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21794237
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20897158
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16554949
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14615115
21FOXP3_21729870_ChIP-Seq_TREG_Human2.13884066
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.13247629
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12033563
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09163664
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.08643977
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06907849
27TTF2_22483619_ChIP-Seq_HELA_Human2.06120718
28XRN2_22483619_ChIP-Seq_HELA_Human2.04124075
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01672797
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98216980
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96302794
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.94346520
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90182320
34FUS_26573619_Chip-Seq_HEK293_Human1.89570393
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.89001353
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.88467584
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88213495
38MYC_18940864_ChIP-ChIP_HL60_Human1.87966771
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84692268
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.84230821
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82936495
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81327059
43DCP1A_22483619_ChIP-Seq_HELA_Human1.80571875
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77740177
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76225815
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75151235
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73371285
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72456264
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70417956
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69157377
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67239516
52ER_23166858_ChIP-Seq_MCF-7_Human1.67023811
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65762838
54P300_19829295_ChIP-Seq_ESCs_Human1.65100733
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63148269
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58588033
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58311151
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58311151
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56394795
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55866153
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52717780
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49620941
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49007808
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48506919
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46916391
66GABP_19822575_ChIP-Seq_HepG2_Human1.46667438
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45965961
68SOX2_16153702_ChIP-ChIP_HESCs_Human1.45799280
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44538778
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43775549
71SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41088838
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40984172
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40588078
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.40125203
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38601835
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37191820
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35712279
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35539558
79IRF1_19129219_ChIP-ChIP_H3396_Human1.35463393
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35344130
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35255635
82RNF2_27304074_Chip-Seq_NSC_Mouse1.34189264
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33579931
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.31476176
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.31126874
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30058825
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28474751
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.27719673
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27391362
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.26749194
91* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26629965
92REST_21632747_ChIP-Seq_MESCs_Mouse1.24543903
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24346485
94IGF1R_20145208_ChIP-Seq_DFB_Human1.24088299
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23735206
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23013032
97AR_21572438_ChIP-Seq_LNCaP_Human1.21614290
98* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20690204
99* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18191543
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.17620041
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16857975
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15406212
103EWS_26573619_Chip-Seq_HEK293_Human1.14849238
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12246159
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.11838070
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11700291
107JUN_21703547_ChIP-Seq_K562_Human1.08544651
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08310634
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.07990918
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.07020157
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06651163
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05459927
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.05403470
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04193892
115HTT_18923047_ChIP-ChIP_STHdh_Human1.03945512
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03693739
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.03689199
118RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03553374
119SMAD4_21799915_ChIP-Seq_A2780_Human1.03364215
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03153919
121TP53_22573176_ChIP-Seq_HFKS_Human1.00370813
122REST_18959480_ChIP-ChIP_MESCs_Mouse0.98308390
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97955695
124ZNF274_21170338_ChIP-Seq_K562_Hela0.97758157
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96501901
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94397436
127P53_22387025_ChIP-Seq_ESCs_Mouse0.94134955
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.92854889
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92789167
130CMYC_18555785_Chip-Seq_ESCs_Mouse0.92777726
131ELK1_22589737_ChIP-Seq_MCF10A_Human0.92695163
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92681677
133MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92478264
134P300_18555785_Chip-Seq_ESCs_Mouse0.92421695
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91441974
136* NANOG_19829295_ChIP-Seq_ESCs_Human0.91368641
137* SOX2_19829295_ChIP-Seq_ESCs_Human0.91368641
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.90213775
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.90021430
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89738365
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89604548
142SOX2_18555785_Chip-Seq_ESCs_Mouse0.89319077
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88046667
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86558723
145E2F1_21310950_ChIP-Seq_MCF-7_Human0.85610357
146KDM5A_27292631_Chip-Seq_BREAST_Human0.85259408
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83060980
148EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82567588
149* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80118333
150CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78970398
151TP63_19390658_ChIP-ChIP_HaCaT_Human0.78524297
152CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76426763
153NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75317343
154SOX17_20123909_ChIP-Seq_XEN_Mouse0.74854900
155ERG_20517297_ChIP-Seq_VCAP_Human0.73204733
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72665291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.68946747
2MP0001529_abnormal_vocalization3.84976303
3MP0009379_abnormal_foot_pigmentation3.66718043
4MP0001905_abnormal_dopamine_level3.07038508
5MP0006276_abnormal_autonomic_nervous2.98332929
6MP0002837_dystrophic_cardiac_calcinosis2.72664247
7MP0003136_yellow_coat_color2.55645652
8MP0005423_abnormal_somatic_nervous2.37170566
9MP0004142_abnormal_muscle_tone2.33027879
10MP0001968_abnormal_touch/_nociception2.29239967
11MP0001440_abnormal_grooming_behavior2.20780458
12MP0002736_abnormal_nociception_after2.19872961
13MP0002272_abnormal_nervous_system2.18071384
14MP0009745_abnormal_behavioral_response2.15195269
15MP0002064_seizures2.12758511
16MP0003941_abnormal_skin_development2.10548230
17MP0009046_muscle_twitch2.03854917
18MP0004270_analgesia2.03323314
19MP0003806_abnormal_nucleotide_metabolis2.00131825
20MP0008058_abnormal_DNA_repair1.90156534
21MP0000920_abnormal_myelination1.89666194
22MP0002572_abnormal_emotion/affect_behav1.86685664
23MP0001486_abnormal_startle_reflex1.85009039
24MP0003635_abnormal_synaptic_transmissio1.84098065
25MP0002734_abnormal_mechanical_nocicepti1.83820021
26MP0008877_abnormal_DNA_methylation1.82570718
27MP0003718_maternal_effect1.79623608
28MP0004742_abnormal_vestibular_system1.75160262
29MP0003693_abnormal_embryo_hatching1.68120085
30MP0003123_paternal_imprinting1.67353187
31MP0005409_darkened_coat_color1.66358738
32MP0004957_abnormal_blastocyst_morpholog1.65733612
33MP0005084_abnormal_gallbladder_morpholo1.65068621
34MP0005171_absent_coat_pigmentation1.63793029
35MP0002735_abnormal_chemical_nociception1.62256843
36MP0001970_abnormal_pain_threshold1.60569356
37MP0002067_abnormal_sensory_capabilities1.57882468
38MP0006036_abnormal_mitochondrial_physio1.57644747
39MP0004924_abnormal_behavior1.55440359
40MP0005386_behavior/neurological_phenoty1.55440359
41MP0001501_abnormal_sleep_pattern1.53556106
42MP0000778_abnormal_nervous_system1.52626856
43MP0008789_abnormal_olfactory_epithelium1.52175814
44MP0000751_myopathy1.51253682
45MP0002822_catalepsy1.50848314
46MP0001293_anophthalmia1.49760742
47MP0003950_abnormal_plasma_membrane1.47520996
48MP0002063_abnormal_learning/memory/cond1.45978402
49MP0002733_abnormal_thermal_nociception1.45221432
50MP0006035_abnormal_mitochondrial_morpho1.45094285
51MP0005645_abnormal_hypothalamus_physiol1.44113070
52MP0003787_abnormal_imprinting1.43586217
53MP0006072_abnormal_retinal_apoptosis1.42672601
54MP0005379_endocrine/exocrine_gland_phen1.42524848
55MP0002638_abnormal_pupillary_reflex1.41239146
56MP0010030_abnormal_orbit_morphology1.41181421
57MP0002163_abnormal_gland_morphology1.40234435
58MP0001188_hyperpigmentation1.40111778
59MP0004145_abnormal_muscle_electrophysio1.40026636
60MP0004381_abnormal_hair_follicle1.39946828
61MP0003121_genomic_imprinting1.36800050
62MP0001485_abnormal_pinna_reflex1.34765634
63MP0005551_abnormal_eye_electrophysiolog1.32745548
64MP0008995_early_reproductive_senescence1.32118268
65MP0002653_abnormal_ependyma_morphology1.30678804
66MP0001984_abnormal_olfaction1.28864812
67MP0004043_abnormal_pH_regulation1.23562388
68MP0010386_abnormal_urinary_bladder1.23557383
69MP0004133_heterotaxia1.21082733
70MP0003646_muscle_fatigue1.20638152
71MP0001986_abnormal_taste_sensitivity1.18294355
72MP0004036_abnormal_muscle_relaxation1.17447970
73MP0004215_abnormal_myocardial_fiber1.17177944
74MP0008875_abnormal_xenobiotic_pharmacok1.15773323
75MP0003122_maternal_imprinting1.13769604
76MP0002184_abnormal_innervation1.13111286
77MP0000372_irregular_coat_pigmentation1.13003380
78MP0002876_abnormal_thyroid_physiology1.12756066
79MP0003137_abnormal_impulse_conducting1.12604314
80MP0004859_abnormal_synaptic_plasticity1.12002062
81MP0010094_abnormal_chromosome_stability1.11764674
82MP0003329_amyloid_beta_deposits1.11468957
83MP0009697_abnormal_copulation1.10798718
84MP0002229_neurodegeneration1.10341106
85MP0000749_muscle_degeneration1.10301091
86MP0005394_taste/olfaction_phenotype1.10092141
87MP0005499_abnormal_olfactory_system1.10092141
88MP0002160_abnormal_reproductive_system1.09153579
89MP0003786_premature_aging1.08755405
90MP0001963_abnormal_hearing_physiology1.08260529
91MP0002332_abnormal_exercise_endurance1.07759777
92MP0002557_abnormal_social/conspecific_i1.07567626
93MP0005646_abnormal_pituitary_gland1.07434414
94MP0008932_abnormal_embryonic_tissue1.06042940
95MP0000026_abnormal_inner_ear1.04266624
96MP0005332_abnormal_amino_acid1.03949417
97MP0001764_abnormal_homeostasis1.02786413
98MP0002066_abnormal_motor_capabilities/c1.02193788
99MP0003567_abnormal_fetal_cardiomyocyte1.01048412
100MP0003195_calcinosis1.00834583
101MP0002752_abnormal_somatic_nervous0.99641653
102MP0002102_abnormal_ear_morphology0.99538795
103MP0005408_hypopigmentation0.98561411
104MP0000049_abnormal_middle_ear0.97514749
105MP0002882_abnormal_neuron_morphology0.97064608
106MP0001727_abnormal_embryo_implantation0.96473083
107MP0005410_abnormal_fertilization0.95908223
108MP0003890_abnormal_embryonic-extraembry0.95138076
109MP0003634_abnormal_glial_cell0.95066701
110MP0002234_abnormal_pharynx_morphology0.92858335
111MP0006292_abnormal_olfactory_placode0.92598280
112MP0005389_reproductive_system_phenotype0.91121442
113MP0003077_abnormal_cell_cycle0.89368953
114MP0008872_abnormal_physiological_respon0.89138002
115MP0005253_abnormal_eye_physiology0.88730674
116MP0000631_abnormal_neuroendocrine_gland0.87935546
117MP0001919_abnormal_reproductive_system0.87338465
118MP0002210_abnormal_sex_determination0.86199033
119MP0001664_abnormal_digestion0.86129349
120MP0003938_abnormal_ear_development0.86024196
121MP0002090_abnormal_vision0.85259103
122MP0005535_abnormal_body_temperature0.85236684
123MP0003315_abnormal_perineum_morphology0.84338449
124MP0003690_abnormal_glial_cell0.83354792
125MP0002938_white_spotting0.83297788
126MP0004147_increased_porphyrin_level0.83229214
127MP0001286_abnormal_eye_development0.80967028
128MP0004484_altered_response_of0.80017270
129MP0005636_abnormal_mineral_homeostasis0.78999160
130MP0005195_abnormal_posterior_eye0.78481239
131MP0000566_synostosis0.77009559
132MP0001502_abnormal_circadian_rhythm0.75496544
133MP0004085_abnormal_heartbeat0.75465700
134MP0002277_abnormal_respiratory_mucosa0.75362874
135MP0003283_abnormal_digestive_organ0.74330499
136MP0003937_abnormal_limbs/digits/tail_de0.73356822
137MP0003011_delayed_dark_adaptation0.71865735
138MP0000955_abnormal_spinal_cord0.71862816
139MP0005330_cardiomyopathy0.70448327
140MP0000538_abnormal_urinary_bladder0.68723759
141MP0000230_abnormal_systemic_arterial0.67861592
142MP0003186_abnormal_redox_activity0.66397184
143MP0008569_lethality_at_weaning0.64731109
144MP0002751_abnormal_autonomic_nervous0.64400388

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.18831248
2Abnormal mitochondria in muscle tissue (HP:0008316)6.43564022
3Mitochondrial inheritance (HP:0001427)6.23933306
4Progressive macrocephaly (HP:0004481)6.11575233
5Acute encephalopathy (HP:0006846)5.89853984
6Increased CSF lactate (HP:0002490)5.18706933
7Hepatocellular necrosis (HP:0001404)5.11713197
8Increased hepatocellular lipid droplets (HP:0006565)4.99862486
9Renal Fanconi syndrome (HP:0001994)4.50004443
10Lipid accumulation in hepatocytes (HP:0006561)4.44131767
11Hepatic necrosis (HP:0002605)4.34581654
12Cerebral edema (HP:0002181)4.14743787
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.03799985
14Optic disc pallor (HP:0000543)3.98463647
15Increased serum pyruvate (HP:0003542)3.92733351
16Abnormality of glycolysis (HP:0004366)3.92733351
17Leukodystrophy (HP:0002415)3.86203846
183-Methylglutaconic aciduria (HP:0003535)3.84074909
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.70025190
20Increased intramyocellular lipid droplets (HP:0012240)3.68545951
21Respiratory failure (HP:0002878)3.66997696
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.65702568
23Parakeratosis (HP:0001036)3.61654724
24Exercise intolerance (HP:0003546)3.54704695
25Lactic acidosis (HP:0003128)3.34054196
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.18001628
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.18001628
28Increased muscle lipid content (HP:0009058)3.08296480
29Exertional dyspnea (HP:0002875)3.05229581
30Abnormality of renal resorption (HP:0011038)3.02838751
31Increased serum lactate (HP:0002151)2.98553927
32Congenital, generalized hypertrichosis (HP:0004540)2.88292580
33Sensory axonal neuropathy (HP:0003390)2.81133324
34Septo-optic dysplasia (HP:0100842)2.67388553
35X-linked dominant inheritance (HP:0001423)2.63510111
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.62169843
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.62169843
38Respiratory difficulties (HP:0002880)2.61757257
39Hypothermia (HP:0002045)2.56224444
40Myokymia (HP:0002411)2.54053576
41Neuroendocrine neoplasm (HP:0100634)2.53340774
42Congenital ichthyosiform erythroderma (HP:0007431)2.52510659
43Pheochromocytoma (HP:0002666)2.50537479
44Hyperglycinemia (HP:0002154)2.49317119
45Muscle hypertrophy of the lower extremities (HP:0008968)2.41122286
46Focal motor seizures (HP:0011153)2.40666319
47Medial flaring of the eyebrow (HP:0010747)2.37435152
48Abnormality of cells of the erythroid lineage (HP:0012130)2.36903166
49Colon cancer (HP:0003003)2.34495177
50Abnormal ciliary motility (HP:0012262)2.33566016
51Aplastic anemia (HP:0001915)2.28976290
52Neurofibrillary tangles (HP:0002185)2.26462407
53Abnormal pupillary function (HP:0007686)2.26276618
54Hyperphosphaturia (HP:0003109)2.25909261
55Pancreatic fibrosis (HP:0100732)2.25738461
56Pancreatic cysts (HP:0001737)2.22199552
57Glycosuria (HP:0003076)2.20827285
58Abnormality of urine glucose concentration (HP:0011016)2.20827285
59Generalized aminoaciduria (HP:0002909)2.19820056
60Abnormality of the labia minora (HP:0012880)2.19274786
61Macrocytic anemia (HP:0001972)2.18617171
62CNS demyelination (HP:0007305)2.14618128
63Oral leukoplakia (HP:0002745)2.13689788
64Type I transferrin isoform profile (HP:0003642)2.12698664
65Abnormality of midbrain morphology (HP:0002418)2.11111403
66Molar tooth sign on MRI (HP:0002419)2.11111403
67Gait imbalance (HP:0002141)2.10499184
68Retinal dysplasia (HP:0007973)2.09474618
69Abnormality of methionine metabolism (HP:0010901)2.08892930
70Abnormality of serum amino acid levels (HP:0003112)2.08155506
71True hermaphroditism (HP:0010459)2.07648378
72Abnormal respiratory epithelium morphology (HP:0012253)2.07540642
73Abnormal respiratory motile cilium morphology (HP:0005938)2.07540642
74Degeneration of anterior horn cells (HP:0002398)2.06856289
75Abnormality of the anterior horn cell (HP:0006802)2.06856289
76Emotional lability (HP:0000712)2.05028703
77Methylmalonic acidemia (HP:0002912)2.04863778
78Limb dystonia (HP:0002451)2.04728160
79Calf muscle hypertrophy (HP:0008981)2.01327491
80Lethargy (HP:0001254)2.00695873
81Congenital primary aphakia (HP:0007707)2.00631618
82Abnormal urine phosphate concentration (HP:0012599)1.98979963
83Hyperglycinuria (HP:0003108)1.98238017
84Abnormal respiratory motile cilium physiology (HP:0012261)1.96326346
85Absent/shortened dynein arms (HP:0200106)1.95598653
86Dynein arm defect of respiratory motile cilia (HP:0012255)1.95598653
87Atonic seizures (HP:0010819)1.95131243
88Abnormal number of erythroid precursors (HP:0012131)1.94803422
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94483769
90Cerebral hemorrhage (HP:0001342)1.94435374
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94353255
92Abnormality of alanine metabolism (HP:0010916)1.94353255
93Hyperalaninemia (HP:0003348)1.94353255
94Hypoglycemic coma (HP:0001325)1.91370334
95Abnormality of the axillary hair (HP:0100134)1.91055340
96Abnormality of secondary sexual hair (HP:0009888)1.91055340
97Absent septum pellucidum (HP:0001331)1.90099947
98Megaloblastic anemia (HP:0001889)1.89201923
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89115369
100Vaginal atresia (HP:0000148)1.88888679
101Maternal diabetes (HP:0009800)1.88287312
102Renal tubular dysfunction (HP:0000124)1.87726832
103Nephrogenic diabetes insipidus (HP:0009806)1.87498518
104Genital tract atresia (HP:0001827)1.86295202
105Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85849755
106Amniotic constriction ring (HP:0009775)1.84246583
107Abnormality of placental membranes (HP:0011409)1.84246583
108Hyperventilation (HP:0002883)1.83804743
109Sclerocornea (HP:0000647)1.82953982
110Nephronophthisis (HP:0000090)1.82261820
111Dicarboxylic aciduria (HP:0003215)1.80945225
112Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80945225
113Abnormality of glycine metabolism (HP:0010895)1.78443563
114Abnormality of serine family amino acid metabolism (HP:0010894)1.78443563
115Methylmalonic aciduria (HP:0012120)1.77636655
116Hyperinsulinemic hypoglycemia (HP:0000825)1.74515474
117Optic nerve hypoplasia (HP:0000609)1.73804216
118Absent thumb (HP:0009777)1.72138491
119Abnormality of vitamin B metabolism (HP:0004340)1.71376989
120Reticulocytopenia (HP:0001896)1.70395752
121Cerebral inclusion bodies (HP:0100314)1.70320206
122Pancytopenia (HP:0001876)1.69506660
123Microvesicular hepatic steatosis (HP:0001414)1.67744581
124Poor suck (HP:0002033)1.67250201
125Pendular nystagmus (HP:0012043)1.66534951
126Abnormality of homocysteine metabolism (HP:0010919)1.64249959
127Homocystinuria (HP:0002156)1.64249959
128Abnormal hair whorl (HP:0010721)1.63741379
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63633346
130Progressive external ophthalmoplegia (HP:0000590)1.63503764
131Abnormality of the vitamin B12 metabolism (HP:0004341)1.62938075
132Hypoplastic left heart (HP:0004383)1.60902093
133Abnormality of the corticospinal tract (HP:0002492)1.60425010
134Blindness (HP:0000618)1.60133233
135Anxiety (HP:0000739)1.59872132
136Abnormal protein glycosylation (HP:0012346)1.59221286
137Abnormal glycosylation (HP:0012345)1.59221286
138Abnormal protein N-linked glycosylation (HP:0012347)1.59221286
139Delusions (HP:0000746)1.59010110
140Abnormal hemoglobin (HP:0011902)1.54781017
141Absence seizures (HP:0002121)1.54775849
142Peripheral hypomyelination (HP:0007182)1.54635299
143Dialeptic seizures (HP:0011146)1.53566112
144Broad-based gait (HP:0002136)1.52487335
145Pallor (HP:0000980)1.52226343
146Metabolic alkalosis (HP:0200114)1.51388447
147Aplasia/hypoplasia of the uterus (HP:0008684)1.50058965
148Cerebral hypomyelination (HP:0006808)1.49332058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.77420357
2STK393.55931251
3CASK3.43923402
4NME12.86249489
5OXSR12.85241352
6MAP3K122.77646238
7PNCK2.61177041
8ZAK2.43873851
9CDC72.43048595
10STK162.38694656
11MST42.36710124
12GRK72.28616002
13PBK2.22527337
14WNK42.03865799
15MAPKAPK52.01674574
16TNIK2.00538355
17NME21.98239454
18NUAK11.97623922
19TAF11.95626390
20BCR1.93419891
21MYLK1.86122065
22GRK51.83412953
23ARAF1.83075939
24BCKDK1.79406142
25MUSK1.76903938
26CDK191.76752633
27TLK11.76599778
28BMPR1B1.58944394
29PLK31.56238458
30NEK11.53532345
31ADRBK21.52923857
32MAP2K71.50533162
33PKN11.47965822
34LIMK11.42534562
35DYRK31.41001358
36EPHA41.35287623
37CAMK2B1.30319182
38MAP4K21.27796030
39WEE11.26011220
40PASK1.24382273
41VRK11.24129697
42NTRK31.23080258
43UHMK11.23041585
44BMPR21.22588988
45CSNK1G31.18261052
46CAMK2A1.17922523
47MAPK131.16689557
48FGR1.15157997
49PLK41.14759903
50TRIM281.14533680
51CAMK2D1.14387654
52MARK11.12531797
53OBSCN1.12418348
54EIF2AK31.10367994
55DYRK21.07858124
56TTK1.06637789
57PLK21.06553639
58PHKG21.05681222
59PHKG11.05681222
60MAPK151.05369012
61WNK31.04468421
62MKNK11.04001050
63MKNK21.02122181
64MAP3K41.00514934
65ADRBK11.00052243
66PLK10.98127007
67ROCK20.92635961
68INSRR0.90863135
69CAMK2G0.90218522
70PRKCE0.89751088
71BRSK20.89193821
72IRAK20.83389941
73AURKB0.80608958
74NTRK10.80447590
75CSNK1G10.79815997
76CSNK2A20.79146481
77TSSK60.78058815
78BUB10.76746980
79CSNK1G20.74729709
80RIPK40.74224827
81DAPK30.69758664
82FES0.68496612
83CSNK2A10.67953895
84BRAF0.66662923
85AURKA0.65307339
86PRKACA0.65285217
87NTRK20.63249740
88CCNB10.62569919
89CHEK20.59667141
90ABL20.58764681
91PAK30.58732587
92NEK60.58238460
93RPS6KA50.58047648
94MINK10.57758496
95PTK2B0.57445530
96CSNK1E0.56561763
97MAP2K40.56294642
98BRSK10.55889686
99FRK0.55849466
100PIM20.55359677
101CDK50.55007976
102CSNK1A1L0.54964273
103STK40.54859513
104CDK140.53667505
105WNK10.53131942
106STK240.52002986
107LRRK20.51556564
108IRAK10.50498825
109PRKCG0.50330358
110GRK10.48887828
111PRKCQ0.48844772
112CDK80.48744475
113EPHB20.48240612
114CSNK1A10.47405894
115TESK20.47369044
116STK30.45192119
117PRKCI0.43731129
118PRKG10.43482211
119PIK3CA0.42200849
120ERBB30.40334366
121CDK180.39762303
122DYRK1A0.39122023
123CDK150.39047800
124MAPK40.38511277
125EIF2AK20.38005698
126CDK30.37822375
127ATR0.37740200
128CDK11A0.36230373
129YES10.36047393
130PRPF4B0.35537068
131STK38L0.35322334
132MET0.34886534
133SGK4940.34086247
134SGK2230.34086247
135PDK20.33025957
136PINK10.33017193
137MOS0.32907878
138ILK0.32615250
139MAPK120.32105534
140EIF2AK10.31297357
141PIK3CG0.31012709
142PRKCA0.30774410
143SRPK10.30652591

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.59774154
2Parkinsons disease_Homo sapiens_hsa050125.49841153
3Alzheimers disease_Homo sapiens_hsa050104.32426691
4Huntingtons disease_Homo sapiens_hsa050163.84723842
5Ribosome_Homo sapiens_hsa030103.44400478
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.40737998
7Cardiac muscle contraction_Homo sapiens_hsa042603.00109321
8Protein export_Homo sapiens_hsa030602.70563146
9Fatty acid elongation_Homo sapiens_hsa000622.37892021
10Proteasome_Homo sapiens_hsa030502.32371323
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.31900159
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21454817
13Collecting duct acid secretion_Homo sapiens_hsa049662.18306090
14Mismatch repair_Homo sapiens_hsa034302.00975573
15Homologous recombination_Homo sapiens_hsa034401.79240079
16DNA replication_Homo sapiens_hsa030301.66629173
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62171477
18Nicotine addiction_Homo sapiens_hsa050331.61169129
19RNA polymerase_Homo sapiens_hsa030201.59804845
20Spliceosome_Homo sapiens_hsa030401.59083295
21Steroid biosynthesis_Homo sapiens_hsa001001.50734960
22Sulfur metabolism_Homo sapiens_hsa009201.50241792
23Nucleotide excision repair_Homo sapiens_hsa034201.42783847
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41824998
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38321756
26RNA degradation_Homo sapiens_hsa030181.35960543
27Vibrio cholerae infection_Homo sapiens_hsa051101.35587182
28Ether lipid metabolism_Homo sapiens_hsa005651.27108483
29One carbon pool by folate_Homo sapiens_hsa006701.23762594
30Serotonergic synapse_Homo sapiens_hsa047261.18368556
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16115971
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12322114
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04551433
34Fanconi anemia pathway_Homo sapiens_hsa034601.03622333
35RNA transport_Homo sapiens_hsa030131.03187252
36Phototransduction_Homo sapiens_hsa047441.02918235
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.01540194
38Base excision repair_Homo sapiens_hsa034101.01451890
39Propanoate metabolism_Homo sapiens_hsa006400.98971400
40Synaptic vesicle cycle_Homo sapiens_hsa047210.97815323
41Pyruvate metabolism_Homo sapiens_hsa006200.97487484
42Butanoate metabolism_Homo sapiens_hsa006500.96288022
43GABAergic synapse_Homo sapiens_hsa047270.95555372
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91923426
45Rheumatoid arthritis_Homo sapiens_hsa053230.90047843
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89443523
47Sulfur relay system_Homo sapiens_hsa041220.88312054
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.86894620
49Taste transduction_Homo sapiens_hsa047420.86527575
50Linoleic acid metabolism_Homo sapiens_hsa005910.84022400
51* Metabolic pathways_Homo sapiens_hsa011000.83733712
52Tyrosine metabolism_Homo sapiens_hsa003500.82889123
53Histidine metabolism_Homo sapiens_hsa003400.80084916
54Morphine addiction_Homo sapiens_hsa050320.78601466
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78144352
56Tryptophan metabolism_Homo sapiens_hsa003800.76960169
57Arachidonic acid metabolism_Homo sapiens_hsa005900.76557334
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74727778
59Glutamatergic synapse_Homo sapiens_hsa047240.73243522
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73175775
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72824711
62Vitamin digestion and absorption_Homo sapiens_hsa049770.72120986
63Sphingolipid metabolism_Homo sapiens_hsa006000.71172764
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70659792
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70333123
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70161627
67Glutathione metabolism_Homo sapiens_hsa004800.67771234
68Phenylalanine metabolism_Homo sapiens_hsa003600.67318785
69Selenocompound metabolism_Homo sapiens_hsa004500.66320761
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65925419
71Renin secretion_Homo sapiens_hsa049240.60747109
72Fatty acid degradation_Homo sapiens_hsa000710.60081802
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60007785
74Non-homologous end-joining_Homo sapiens_hsa034500.59015725
75Long-term depression_Homo sapiens_hsa047300.58010771
76Amphetamine addiction_Homo sapiens_hsa050310.57863605
77Cocaine addiction_Homo sapiens_hsa050300.54260665
78Circadian entrainment_Homo sapiens_hsa047130.53841733
79Vitamin B6 metabolism_Homo sapiens_hsa007500.53445761
80Dopaminergic synapse_Homo sapiens_hsa047280.53022700
81Nitrogen metabolism_Homo sapiens_hsa009100.52654126
82Pyrimidine metabolism_Homo sapiens_hsa002400.52185390
83Arginine and proline metabolism_Homo sapiens_hsa003300.50706280
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48910479
85Peroxisome_Homo sapiens_hsa041460.48567880
86Salivary secretion_Homo sapiens_hsa049700.48449115
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48317258
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.48047740
89Calcium signaling pathway_Homo sapiens_hsa040200.47891979
90Caffeine metabolism_Homo sapiens_hsa002320.47599961
91Purine metabolism_Homo sapiens_hsa002300.45973099
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45130727
93Phagosome_Homo sapiens_hsa041450.43766246
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43037779
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42445125
96Axon guidance_Homo sapiens_hsa043600.38831245
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38272631
98Biosynthesis of amino acids_Homo sapiens_hsa012300.38180190
99Cholinergic synapse_Homo sapiens_hsa047250.36157336
100Gastric acid secretion_Homo sapiens_hsa049710.35917742
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35642683
102Cell cycle_Homo sapiens_hsa041100.35235362
103Chemical carcinogenesis_Homo sapiens_hsa052040.34843446
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33822145
105Fat digestion and absorption_Homo sapiens_hsa049750.33465621
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.33438155
107Autoimmune thyroid disease_Homo sapiens_hsa053200.31699444
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.31146666
109Olfactory transduction_Homo sapiens_hsa047400.30976591
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30179358
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29894038
112Systemic lupus erythematosus_Homo sapiens_hsa053220.28643345
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27927386
114Regulation of autophagy_Homo sapiens_hsa041400.27851308
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26419815
116Fatty acid metabolism_Homo sapiens_hsa012120.26064464
117Long-term potentiation_Homo sapiens_hsa047200.25909396
118Oocyte meiosis_Homo sapiens_hsa041140.25871363
119Basal transcription factors_Homo sapiens_hsa030220.25478805
120Pancreatic secretion_Homo sapiens_hsa049720.24511092
121Folate biosynthesis_Homo sapiens_hsa007900.24064870
122Basal cell carcinoma_Homo sapiens_hsa052170.22336726
123African trypanosomiasis_Homo sapiens_hsa051430.21428176
124Asthma_Homo sapiens_hsa053100.20494045
125Insulin secretion_Homo sapiens_hsa049110.19846272
126Dilated cardiomyopathy_Homo sapiens_hsa054140.19548226
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18245642
128Carbon metabolism_Homo sapiens_hsa012000.17964435
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.17568053
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17112932
131Alcoholism_Homo sapiens_hsa050340.16759519
132Arginine biosynthesis_Homo sapiens_hsa002200.16662076
133Oxytocin signaling pathway_Homo sapiens_hsa049210.16542477
134mRNA surveillance pathway_Homo sapiens_hsa030150.16086488
135Retinol metabolism_Homo sapiens_hsa008300.15523625
136Graft-versus-host disease_Homo sapiens_hsa053320.15205195
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15051110
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14335447
139beta-Alanine metabolism_Homo sapiens_hsa004100.14223957
140Mineral absorption_Homo sapiens_hsa049780.12904339
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12002963

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