ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	inositol phosphate dephosphorylation (GO:0046855)	6.33093402
2	phosphorylated carbohydrate dephosphorylation (GO:0046838)	6.33093402
3	inositol phosphate catabolic process (GO:0071545)	6.30970809
4	artery smooth muscle contraction (GO:0014824)	5.66294261
5	tonic smooth muscle contraction (GO:0014820)	5.01148219
6	tachykinin receptor signaling pathway (GO:0007217)	4.84361711
7	DNA deamination (GO:0045006)	4.67639012
8	inositol phosphate-mediated signaling (GO:0048016)	4.42230282
9	negative regulation of cAMP-mediated signaling (GO:0043951)	4.36789104
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.32406289
11	vascular smooth muscle contraction (GO:0014829)	4.22124010
12	regulation of hexokinase activity (GO:1903299)	4.15927344
13	regulation of glucokinase activity (GO:0033131)	4.15927344
14	polyol catabolic process (GO:0046174)	4.14189481
15	regulation of oxidative phosphorylation (GO:0002082)	4.11721080
16	dopamine transport (GO:0015872)	4.09978681
17	fucose catabolic process (GO:0019317)	4.01102856
18	L-fucose metabolic process (GO:0042354)	4.01102856
19	L-fucose catabolic process (GO:0042355)	4.01102856
20	protein prenylation (GO:0018342)	3.90903050
21	prenylation (GO:0097354)	3.90903050
22	regulation of relaxation of muscle (GO:1901077)	3.84155997
23	lactate metabolic process (GO:0006089)	3.69785086
24	signal peptide processing (GO:0006465)	3.66395431
25	aggressive behavior (GO:0002118)	3.66081477
26	leukotriene biosynthetic process (GO:0019370)	3.65677551
27	protein complex biogenesis (GO:0070271)	3.65196879
28	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.57859980
29	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.49204962
30	positive regulation of action potential (GO:0045760)	3.43336717
31	platelet dense granule organization (GO:0060155)	3.42982130
32	tyrosine metabolic process (GO:0006570)	3.36692403
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.31547866
34	respiratory electron transport chain (GO:0022904)	3.30830604
35	electron transport chain (GO:0022900)	3.24020368
36	norepinephrine metabolic process (GO:0042415)	3.21281453
37	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.18765175
38	positive regulation of digestive system process (GO:0060456)	3.18567100
39	positive regulation of vascular permeability (GO:0043117)	3.17129325
40	regulation of protein glycosylation (GO:0060049)	3.15423649
41	somite rostral/caudal axis specification (GO:0032525)	3.15100828
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.06386488
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.06386488
44	RNA destabilization (GO:0050779)	3.05785971
45	nitric oxide biosynthetic process (GO:0006809)	3.01147587
46	insulin secretion (GO:0030073)	3.01143514
47	positive regulation of histone H3-K4 methylation (GO:0051571)	3.00728221
48	tryptophan metabolic process (GO:0006568)	3.00447802
49	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.97997892
50	cytidine deamination (GO:0009972)	2.92851838
51	cytidine metabolic process (GO:0046087)	2.92851838
52	cytidine catabolic process (GO:0006216)	2.92851838
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.89707486
54	NADH dehydrogenase complex assembly (GO:0010257)	2.89707486
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.89707486
56	brain morphogenesis (GO:0048854)	2.88855590
57	ATP synthesis coupled proton transport (GO:0015986)	2.88206716
58	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.88206716
59	regulation of mitochondrial translation (GO:0070129)	2.84756933
60	regulation of action potential (GO:0098900)	2.84278795
61	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.83819083
62	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.83295653
63	phasic smooth muscle contraction (GO:0014821)	2.79427745
64	behavioral response to pain (GO:0048266)	2.77089662
65	mannosylation (GO:0097502)	2.76590052
66	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.73487238
67	regulation of cellular respiration (GO:0043457)	2.72853192
68	regulation of uterine smooth muscle contraction (GO:0070472)	2.72361065
69	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.72160188
70	regulation of appetite (GO:0032098)	2.71967625
71	catecholamine transport (GO:0051937)	2.70979697
72	primary amino compound metabolic process (GO:1901160)	2.70635823
73	glutathione biosynthetic process (GO:0006750)	2.69269772
74	protein targeting to Golgi (GO:0000042)	2.67555629
75	negative regulation of protein oligomerization (GO:0032460)	2.65036244
76	regulation of cell communication by electrical coupling (GO:0010649)	2.64809472
77	negative regulation of mast cell activation (GO:0033004)	2.62853457
78	establishment of protein localization to Golgi (GO:0072600)	2.61142109
79	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.60481081
80	auditory receptor cell stereocilium organization (GO:0060088)	2.58447489
81	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.57069530
82	indolalkylamine metabolic process (GO:0006586)	2.56458335
83	neuronal action potential propagation (GO:0019227)	2.56288492
84	nonribosomal peptide biosynthetic process (GO:0019184)	2.55410735
85	translesion synthesis (GO:0019985)	2.54715281
86	cysteine metabolic process (GO:0006534)	2.54515739
87	respiratory chain complex IV assembly (GO:0008535)	2.51266621
88	smooth muscle contraction (GO:0006939)	2.50340735
89	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.48374289
90	peptide hormone secretion (GO:0030072)	2.48200533
91	regulation of cilium movement (GO:0003352)	2.47123686
92	keratinocyte development (GO:0003334)	2.46697519
93	left/right axis specification (GO:0070986)	2.46178331
94	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.42883681
95	proton transport (GO:0015992)	2.41495630
96	glutathione metabolic process (GO:0006749)	2.41163718
97	hydrogen transport (GO:0006818)	2.41019147
98	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.40739575
99	cellular ketone body metabolic process (GO:0046950)	2.40600213
100	cytochrome complex assembly (GO:0017004)	2.40404196

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.66241431
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.46570736
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.97621003
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92600524
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.61111410
6	VDR_22108803_ChIP-Seq_LS180_Human	2.58863704
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38140444
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27423522
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.27183088
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27162444
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.26243386
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.20850100
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.19137509
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.04378009
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.89458336
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.86363279
17	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.84271282
18	P300_19829295_ChIP-Seq_ESCs_Human	1.83786271
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82688465
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79920355
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78592152
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.76455044
23	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.74054588
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73779899
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.70406838
26	FUS_26573619_Chip-Seq_HEK293_Human	1.69937765
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68255986
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.65298233
29	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.59578874
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.59433593
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58650919
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53695440
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.53547650
34	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.47496032
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46749119
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43856133
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.43008603
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43008603
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41945095
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38598483
41	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.37917694
42	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35892321
43	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.35655730
44	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.35496002
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35485729
46	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.35395118
47	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.35072384
48	ELK1_19687146_ChIP-ChIP_HELA_Human	1.34970578
49	GATA1_22025678_ChIP-Seq_K562_Human	1.34171346
50	EWS_26573619_Chip-Seq_HEK293_Human	1.33303576
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33112443
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32989446
53	P53_22387025_ChIP-Seq_ESCs_Mouse	1.32205862
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31147434
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30464105
56	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.30438317
57	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.30411553
58	AR_25329375_ChIP-Seq_VCAP_Human	1.29872891
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29529935
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29291196
61	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.28669341
62	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.27355602
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24940507
64	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.23450109
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23057891
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22620714
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22556264
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.22324789
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20609387
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20609387
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19665840
72	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.18855550
73	P300_18555785_Chip-Seq_ESCs_Mouse	1.18642449
74	STAT3_23295773_ChIP-Seq_U87_Human	1.17917385
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17669306
76	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.16744795
77	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.16101993
78	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.15920474
79	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.15085449
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15013484
81	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.14981201
82	HTT_18923047_ChIP-ChIP_STHdh_Human	1.14366918
83	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.14109430
84	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.14064942
85	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.14035889
86	VDR_23849224_ChIP-Seq_CD4+_Human	1.13682061
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12658966
88	MYC_18940864_ChIP-ChIP_HL60_Human	1.12607608
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12590696
90	TCF4_23295773_ChIP-Seq_U87_Human	1.11765761
91	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08535775
92	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07888936
93	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.05962827
94	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.04608260
95	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.02401033
96	PU1_27457419_Chip-Seq_LIVER_Mouse	1.00270244
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98227767
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95529614
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95529614
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.95139581

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.13855372
2	MP0008057_abnormal_DNA_replication	3.72639506
3	MP0000013_abnormal_adipose_tissue	3.72566635
4	MP0000372_irregular_coat_pigmentation	3.69670720
5	MP0005645_abnormal_hypothalamus_physiol	3.46184355
6	MP0002163_abnormal_gland_morphology	3.41842024
7	MP0005379_endocrine/exocrine_gland_phen	2.98960641
8	MP0005075_abnormal_melanosome_morpholog	2.77655167
9	MP0002909_abnormal_adrenal_gland	2.61200920
10	MP0003195_calcinosis	2.54259961
11	MP0001529_abnormal_vocalization	2.49863413
12	MP0003646_muscle_fatigue	2.28274409
13	MP0006072_abnormal_retinal_apoptosis	2.19282802
14	MP0004147_increased_porphyrin_level	2.12006367
15	MP0009379_abnormal_foot_pigmentation	2.06956719
16	MP0008995_early_reproductive_senescence	2.03541251
17	MP0004145_abnormal_muscle_electrophysio	2.03068816
18	MP0002938_white_spotting	2.02075130
19	MP0008872_abnormal_physiological_respon	1.99702699
20	MP0001968_abnormal_touch/_nociception	1.96475711
21	MP0002735_abnormal_chemical_nociception	1.89483992
22	MP0001984_abnormal_olfaction	1.84813314
23	MP0005171_absent_coat_pigmentation	1.81111378
24	MP0002102_abnormal_ear_morphology	1.79484679
25	MP0004142_abnormal_muscle_tone	1.78678738
26	MP0009697_abnormal_copulation	1.69802709
27	MP0005670_abnormal_white_adipose	1.68809894
28	MP0002736_abnormal_nociception_after	1.66182321
29	MP0005332_abnormal_amino_acid	1.58538010
30	MP0002277_abnormal_respiratory_mucosa	1.54967463
31	MP0003786_premature_aging	1.51918774
32	MP0005551_abnormal_eye_electrophysiolog	1.48202615
33	MP0005248_abnormal_Harderian_gland	1.46869146
34	MP0002933_joint_inflammation	1.46206729
35	MP0002272_abnormal_nervous_system	1.44499189
36	MP0002139_abnormal_hepatobiliary_system	1.39330419
37	MP0004270_analgesia	1.39105070
38	MP0001756_abnormal_urination	1.39062231
39	MP0005646_abnormal_pituitary_gland	1.38097259
40	MP0001944_abnormal_pancreas_morphology	1.34665363
41	MP0001661_extended_life_span	1.32939617
42	MP0002166_altered_tumor_susceptibility	1.32287626
43	MP0004019_abnormal_vitamin_homeostasis	1.32062794
44	MP0005253_abnormal_eye_physiology	1.31531319
45	MP0008789_abnormal_olfactory_epithelium	1.30811456
46	MP0003122_maternal_imprinting	1.28399941
47	MP0002138_abnormal_hepatobiliary_system	1.25971775
48	MP0003806_abnormal_nucleotide_metabolis	1.25336952
49	MP0005386_behavior/neurological_phenoty	1.20127750
50	MP0004924_abnormal_behavior	1.20127750
51	MP0002009_preneoplasia	1.19478057
52	MP0002638_abnormal_pupillary_reflex	1.18658595
53	MP0009745_abnormal_behavioral_response	1.18650529
54	MP0002822_catalepsy	1.17654931
55	MP0009046_muscle_twitch	1.16511110
56	MP0002693_abnormal_pancreas_physiology	1.14245243
57	MP0002751_abnormal_autonomic_nervous	1.13895901
58	MP0002734_abnormal_mechanical_nocicepti	1.13041442
59	MP0003183_abnormal_peptide_metabolism	1.12829428
60	MP0001905_abnormal_dopamine_level	1.09860994
61	MP0001873_stomach_inflammation	1.08208928
62	MP0009780_abnormal_chondrocyte_physiolo	1.07141338
63	MP0000749_muscle_degeneration	1.06034475
64	MP0000230_abnormal_systemic_arterial	1.02354897
65	MP0005266_abnormal_metabolism	1.01356987
66	MP0000631_abnormal_neuroendocrine_gland	1.01192261
67	MP0001970_abnormal_pain_threshold	1.00950596
68	MP0008877_abnormal_DNA_methylation	0.99161515
69	MP0002067_abnormal_sensory_capabilities	0.96321222
70	MP0002108_abnormal_muscle_morphology	0.94049532
71	MP0001986_abnormal_taste_sensitivity	0.90664649
72	MP0006036_abnormal_mitochondrial_physio	0.90463597
73	MP0000003_abnormal_adipose_tissue	0.89494445
74	MP0010234_abnormal_vibrissa_follicle	0.87457230
75	MP0001440_abnormal_grooming_behavior	0.85910162
76	MP0001188_hyperpigmentation	0.84971610
77	MP0002078_abnormal_glucose_homeostasis	0.84727170
78	MP0004036_abnormal_muscle_relaxation	0.82780633
79	MP0005220_abnormal_exocrine_pancreas	0.81659882
80	MP0000639_abnormal_adrenal_gland	0.80720660
81	MP0004215_abnormal_myocardial_fiber	0.80485292
82	MP0003121_genomic_imprinting	0.79742152
83	MP0003252_abnormal_bile_duct	0.78634664
84	MP0003137_abnormal_impulse_conducting	0.78060858
85	MP0002557_abnormal_social/conspecific_i	0.76679333
86	MP0005410_abnormal_fertilization	0.73569365
87	MP0002006_tumorigenesis	0.73556498
88	MP0000427_abnormal_hair_cycle	0.71046167
89	MP0005499_abnormal_olfactory_system	0.69756530
90	MP0005394_taste/olfaction_phenotype	0.69756530
91	MP0001765_abnormal_ion_homeostasis	0.69586971
92	MP0003787_abnormal_imprinting	0.68671303
93	MP0005408_hypopigmentation	0.67395000
94	MP0004133_heterotaxia	0.67190881
95	MP0005369_muscle_phenotype	0.66410060
96	MP0000613_abnormal_salivary_gland	0.65337112
97	MP0002106_abnormal_muscle_physiology	0.64531391
98	MP0005620_abnormal_muscle_contractility	0.63967593
99	MP0005448_abnormal_energy_balance	0.63510424
100	MP0005535_abnormal_body_temperature	0.62452919

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Patchy hypopigmentation of hair (HP:0011365)	4.41716602
2	Hypothermia (HP:0002045)	4.15526875
3	White forelock (HP:0002211)	4.02162435
4	Acute necrotizing encephalopathy (HP:0006965)	3.79571446
5	Progressive macrocephaly (HP:0004481)	3.61924844
6	Blue irides (HP:0000635)	3.49591050
7	Amyotrophic lateral sclerosis (HP:0007354)	3.41385415
8	Renal cortical cysts (HP:0000803)	3.32827864
9	Abnormality of the renal cortex (HP:0011035)	3.30325241
10	Mitochondrial inheritance (HP:0001427)	3.25764395
11	Hypomagnesemia (HP:0002917)	3.24781243
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.13694003
13	Congenital, generalized hypertrichosis (HP:0004540)	3.07164675
14	Nemaline bodies (HP:0003798)	3.00743113
15	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.96796604
16	Muscle fiber inclusion bodies (HP:0100299)	2.96259770
17	Abnormality of midbrain morphology (HP:0002418)	2.90400639
18	Molar tooth sign on MRI (HP:0002419)	2.90400639
19	Renal Fanconi syndrome (HP:0001994)	2.89950332
20	3-Methylglutaconic aciduria (HP:0003535)	2.88906958
21	Acute encephalopathy (HP:0006846)	2.87545651
22	Increased CSF lactate (HP:0002490)	2.81782463
23	Gaze-evoked nystagmus (HP:0000640)	2.76137602
24	Large for gestational age (HP:0001520)	2.75945406
25	Increased hepatocellular lipid droplets (HP:0006565)	2.75425896
26	Arthropathy (HP:0003040)	2.69162404
27	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.68741399
28	Hypoplasia of the fovea (HP:0007750)	2.68741399
29	Abnormality of magnesium homeostasis (HP:0004921)	2.67009655
30	Thyroid-stimulating hormone excess (HP:0002925)	2.61020816
31	Rib fusion (HP:0000902)	2.56841388
32	Anomalous pulmonary venous return (HP:0010772)	2.54858378
33	Ureteral obstruction (HP:0006000)	2.50207406
34	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.48825141
35	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.48825141
36	Hepatic necrosis (HP:0002605)	2.47200187
37	Abnormality of the prostate (HP:0008775)	2.41925431
38	Medial flaring of the eyebrow (HP:0010747)	2.40038821
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.38963404
40	Abnormality of the fovea (HP:0000493)	2.37082424
41	Calf muscle hypertrophy (HP:0008981)	2.36033005
42	Conjunctival telangiectasia (HP:0000524)	2.34873228
43	Broad ribs (HP:0000885)	2.34047184
44	Heterochromia iridis (HP:0001100)	2.33068529
45	Lipid accumulation in hepatocytes (HP:0006561)	2.31051056
46	Rimmed vacuoles (HP:0003805)	2.30853596
47	Broad-based gait (HP:0002136)	2.30631030
48	Nonprogressive disorder (HP:0003680)	2.30292831
49	Nephronophthisis (HP:0000090)	2.28218966
50	Tubular atrophy (HP:0000092)	2.25537267
51	Cerebral edema (HP:0002181)	2.25055238
52	Muscle hypertrophy of the lower extremities (HP:0008968)	2.24269620
53	Methylmalonic acidemia (HP:0002912)	2.24247671
54	Abnormal rod and cone electroretinograms (HP:0008323)	2.21124817
55	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.21110078
56	Hepatocellular necrosis (HP:0001404)	2.19701621
57	Abnormality of the pulmonary veins (HP:0011718)	2.18150484
58	Polyuria (HP:0000103)	2.17947953
59	Postural tremor (HP:0002174)	2.17387025
60	Glycosuria (HP:0003076)	2.17306021
61	Abnormality of urine glucose concentration (HP:0011016)	2.17306021
62	Hyperglycemia (HP:0003074)	2.17120023
63	Disproportionate short-trunk short stature (HP:0003521)	2.16243788
64	Severe muscular hypotonia (HP:0006829)	2.10433458
65	Abnormality of the renal medulla (HP:0100957)	2.09133647
66	Thyroiditis (HP:0100646)	2.07932617
67	Abnormality of renal resorption (HP:0011038)	2.04670360
68	Abnormality of macular pigmentation (HP:0008002)	2.03857588
69	Aplasia/Hypoplasia of the macula (HP:0008059)	2.03457867
70	Hypoproteinemia (HP:0003075)	2.00649569
71	Gait imbalance (HP:0002141)	1.96529533
72	Febrile seizures (HP:0002373)	1.94579605
73	Polydipsia (HP:0001959)	1.93106009
74	Abnormal drinking behavior (HP:0030082)	1.93106009
75	Short chin (HP:0000331)	1.92295376
76	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.87847651
77	Hypoglycemic seizures (HP:0002173)	1.87206335
78	Hypophosphatemic rickets (HP:0004912)	1.86138278
79	Orthostatic hypotension (HP:0001278)	1.84735318
80	Insulin-resistant diabetes mellitus (HP:0000831)	1.84140425
81	Tongue fasciculations (HP:0001308)	1.82930892
82	Retinal dysplasia (HP:0007973)	1.82783697
83	Respiratory failure (HP:0002878)	1.81295484
84	Congenital primary aphakia (HP:0007707)	1.80902941
85	Pulmonary fibrosis (HP:0002206)	1.80389751
86	Ureteral stenosis (HP:0000071)	1.80147539
87	Abnormality of vitamin B metabolism (HP:0004340)	1.79721178
88	J-shaped sella turcica (HP:0002680)	1.78517163
89	Woolly hair (HP:0002224)	1.77229657
90	Tubulointerstitial fibrosis (HP:0005576)	1.77220901
91	Type II lissencephaly (HP:0007260)	1.77039542
92	Fibular aplasia (HP:0002990)	1.76549381
93	Abnormal urine output (HP:0012590)	1.75972010
94	Optic disc pallor (HP:0000543)	1.75815862
95	Abnormality of ocular smooth pursuit (HP:0000617)	1.74997744
96	Hyperphosphaturia (HP:0003109)	1.70872851
97	Hypokalemic alkalosis (HP:0001949)	1.70517053
98	Beaking of vertebral bodies (HP:0004568)	1.70213091
99	Congenital stationary night blindness (HP:0007642)	1.69738081
100	Lactic acidosis (HP:0003128)	1.69582247

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.75132377
2	PHKG1	3.21459460
3	PHKG2	3.21459460
4	ZAK	3.18649614
5	OBSCN	3.05037108
6	MST4	2.80168769
7	CAMKK2	2.54527124
8	ERBB3	2.48148217
9	GRK1	2.43464788
10	WNK3	2.28896767
11	MAPK13	2.21373640
12	SRPK1	2.08702705
13	LIMK1	1.87639536
14	TXK	1.84887561
15	MAP3K4	1.71933635
16	NUAK1	1.64383824
17	BMPR1B	1.63480774
18	TNK2	1.62047484
19	BRSK2	1.42642104
20	TLK1	1.40806083
21	BRD4	1.39891930
22	BMPR2	1.36244489
23	CASK	1.32027605
24	LATS1	1.30870658
25	MKNK2	1.28522790
26	KDR	1.23034520
27	PINK1	1.17509915
28	ADRBK2	1.16056783
29	WNK4	1.13987510
30	FER	1.07397360
31	BCR	1.01495641
32	CSNK1G1	1.00146690
33	STK39	0.99760407
34	MAP4K2	0.99502184
35	FGFR2	0.98266947
36	DAPK2	0.96613201
37	KIT	0.92818166
38	UHMK1	0.89978004
39	CDK8	0.87833592
40	PRKAA1	0.86939132
41	TRIM28	0.82050672
42	CSNK1G2	0.80366682
43	CSNK1G3	0.79862804
44	OXSR1	0.79091999
45	ACVR1B	0.78606580
46	PRKAA2	0.78554647
47	STK38L	0.76900403
48	SCYL2	0.75495792
49	CAMK2A	0.74644793
50	PLK2	0.73805942
51	PRKCE	0.72886214
52	PIK3CA	0.70238691
53	HIPK2	0.69457698
54	MARK1	0.68937747
55	STK16	0.68852999
56	MAP2K7	0.68448193
57	PTK2B	0.67629413
58	CAMK2D	0.62785153
59	MAP3K12	0.62244652
60	VRK1	0.61615368
61	TRPM7	0.60853484
62	IKBKE	0.60468458
63	ADRBK1	0.59660353
64	BCKDK	0.57692913
65	TNIK	0.54410435
66	INSRR	0.54343726
67	NTRK3	0.53960150
68	PRKCG	0.53469016
69	PNCK	0.53194451
70	PRKACA	0.52331322
71	CAMKK1	0.51793654
72	YES1	0.51677299
73	CAMK2B	0.48821750
74	PLK3	0.46205961
75	DYRK3	0.45873806
76	SYK	0.45851453
77	DYRK2	0.45709269
78	TIE1	0.44824203
79	CAMK4	0.43277799
80	MYLK	0.42482012
81	MATK	0.41612061
82	LYN	0.41061484
83	MAP3K7	0.40689394
84	ABL2	0.40651880
85	PRKG1	0.38495788
86	TAOK3	0.37508185
87	EGFR	0.37408647
88	MKNK1	0.37289834
89	NEK6	0.37092667
90	CAMK2G	0.36533706
91	NLK	0.36460366
92	PRKCQ	0.35914104
93	IKBKB	0.34583157
94	CCNB1	0.34268678
95	GRK5	0.34062610
96	VRK2	0.34045164
97	PRKCA	0.33248969
98	STK11	0.33158723
99	ATR	0.30955250
100	SGK2	0.30867724

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.82242714
2	Parkinsons disease_Homo sapiens_hsa05012	3.17265374
3	Protein export_Homo sapiens_hsa03060	2.88094298
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.76788473
5	Asthma_Homo sapiens_hsa05310	2.71188910
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.45972497
7	Alzheimers disease_Homo sapiens_hsa05010	2.41631846
8	Mismatch repair_Homo sapiens_hsa03430	2.27164703
9	Folate biosynthesis_Homo sapiens_hsa00790	2.15162694
10	Huntingtons disease_Homo sapiens_hsa05016	2.05286830
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99975481
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.92980915
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.92549846
14	Proteasome_Homo sapiens_hsa03050	1.92294421
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.82929112
16	Homologous recombination_Homo sapiens_hsa03440	1.82678962
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.81993669
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.79002639
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.77598107
20	Allograft rejection_Homo sapiens_hsa05330	1.77037869
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.69255724
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.67468224
23	Butanoate metabolism_Homo sapiens_hsa00650	1.59776145
24	RNA polymerase_Homo sapiens_hsa03020	1.51666633
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48215270
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.48157619
27	Insulin secretion_Homo sapiens_hsa04911	1.46728444
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.40561803
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.39961027
30	Sulfur metabolism_Homo sapiens_hsa00920	1.38984804
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34745165
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.32596199
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32343596
34	Renin secretion_Homo sapiens_hsa04924	1.31615916
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.27172702
36	Propanoate metabolism_Homo sapiens_hsa00640	1.26757075
37	Basal transcription factors_Homo sapiens_hsa03022	1.21019944
38	Circadian rhythm_Homo sapiens_hsa04710	1.18250088
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.17258831
40	Amphetamine addiction_Homo sapiens_hsa05031	1.09319173
41	Linoleic acid metabolism_Homo sapiens_hsa00591	1.08750772
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04724123
43	Rheumatoid arthritis_Homo sapiens_hsa05323	0.95273703
44	ABC transporters_Homo sapiens_hsa02010	0.89683697
45	Glucagon signaling pathway_Homo sapiens_hsa04922	0.88972852
46	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.87026339
47	Antigen processing and presentation_Homo sapiens_hsa04612	0.86924516
48	Taste transduction_Homo sapiens_hsa04742	0.86774009
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86051781
50	Olfactory transduction_Homo sapiens_hsa04740	0.85968704
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.85846137
52	Regulation of autophagy_Homo sapiens_hsa04140	0.85599706
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.84880157
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.84383276
55	Type II diabetes mellitus_Homo sapiens_hsa04930	0.84082286
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.81934792
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.80687030
58	Circadian entrainment_Homo sapiens_hsa04713	0.80303067
59	Oocyte meiosis_Homo sapiens_hsa04114	0.74630564
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73595422
61	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.73285402
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73022532
63	Long-term potentiation_Homo sapiens_hsa04720	0.72389227
64	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.71210650
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69087296
66	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69018348
67	RNA degradation_Homo sapiens_hsa03018	0.68344653
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64914249
69	DNA replication_Homo sapiens_hsa03030	0.64895422
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.64117789
71	Caffeine metabolism_Homo sapiens_hsa00232	0.62559146
72	GABAergic synapse_Homo sapiens_hsa04727	0.62216877
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60026059
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.55867023
75	Phototransduction_Homo sapiens_hsa04744	0.55176155
76	Purine metabolism_Homo sapiens_hsa00230	0.55026465
77	Serotonergic synapse_Homo sapiens_hsa04726	0.54360415
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.53420741
79	Viral myocarditis_Homo sapiens_hsa05416	0.53247091
80	Morphine addiction_Homo sapiens_hsa05032	0.51571241
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50034069
82	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.49455631
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.48847202
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44592615
85	Metabolic pathways_Homo sapiens_hsa01100	0.44540800
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42515572
87	Salivary secretion_Homo sapiens_hsa04970	0.41961466
88	Nicotine addiction_Homo sapiens_hsa05033	0.41685411
89	Ribosome_Homo sapiens_hsa03010	0.40750155
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40680645
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37883676
92	Primary immunodeficiency_Homo sapiens_hsa05340	0.35691915
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35030882
94	Fatty acid degradation_Homo sapiens_hsa00071	0.29198094
95	Retinol metabolism_Homo sapiens_hsa00830	0.28128051
96	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.27125637
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26790602
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.25888881
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24578530
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.24388340

NDUFB4P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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