NDUFB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)9.89104434
2ATP synthesis coupled proton transport (GO:0015986)9.89104434
3* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.48370416
4* respiratory electron transport chain (GO:0022904)8.81930637
5* electron transport chain (GO:0022900)8.59696767
6oxidative phosphorylation (GO:0006119)5.90274450
7ATP biosynthetic process (GO:0006754)5.65956832
8tricarboxylic acid cycle (GO:0006099)5.55834998
9purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.23391888
10purine nucleoside triphosphate biosynthetic process (GO:0009145)5.15875072
11protein complex biogenesis (GO:0070271)5.09939088
12hydrogen ion transmembrane transport (GO:1902600)5.07511114
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.98092172
14NADH dehydrogenase complex assembly (GO:0010257)4.98092172
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.98092172
16inner mitochondrial membrane organization (GO:0007007)4.88488436
17chaperone-mediated protein transport (GO:0072321)4.79359393
18mitochondrial respiratory chain complex assembly (GO:0033108)4.70652063
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.69198005
20ribonucleoside triphosphate biosynthetic process (GO:0009201)4.57679814
21proton transport (GO:0015992)4.45297233
22hydrogen transport (GO:0006818)4.38806127
23aerobic respiration (GO:0009060)4.36701381
24NADH metabolic process (GO:0006734)4.35200820
25regulation of mitochondrial translation (GO:0070129)4.03426575
26succinate metabolic process (GO:0006105)4.01836265
27nucleoside triphosphate biosynthetic process (GO:0009142)3.99602176
28regulation of acyl-CoA biosynthetic process (GO:0050812)3.98404374
29positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.94474448
30protein neddylation (GO:0045116)3.94397507
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.86078457
32regulation of oxidative phosphorylation (GO:0002082)3.79914851
33ubiquinone biosynthetic process (GO:0006744)3.76050045
34quinone biosynthetic process (GO:1901663)3.76050045
35GTP biosynthetic process (GO:0006183)3.74414581
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.74150689
37regulation of cell communication by electrical coupling (GO:0010649)3.73515142
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.70610750
39cotranslational protein targeting to membrane (GO:0006613)3.70310572
40muscle filament sliding (GO:0030049)3.70298143
41actin-myosin filament sliding (GO:0033275)3.70298143
42sarcomere organization (GO:0045214)3.69761795
43ribosomal small subunit assembly (GO:0000028)3.69253409
44viral transcription (GO:0019083)3.67386566
45regulation of coenzyme metabolic process (GO:0051196)3.66194316
46regulation of cofactor metabolic process (GO:0051193)3.66194316
47heart process (GO:0003015)3.65090822
48heart contraction (GO:0060047)3.65090822
49protein targeting to ER (GO:0045047)3.63939075
50translational termination (GO:0006415)3.61530544
51mitochondrial transport (GO:0006839)3.60850317
52cellular respiration (GO:0045333)3.55056447
53regulation of relaxation of muscle (GO:1901077)3.53700273
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52686645
55protein localization to endoplasmic reticulum (GO:0070972)3.49523574
56purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.46837248
57purine nucleoside monophosphate biosynthetic process (GO:0009127)3.46837248
58* generation of precursor metabolites and energy (GO:0006091)3.46418708
59ATP hydrolysis coupled proton transport (GO:0015991)3.44934517
60energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.44934517
61regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.42109810
62regulation of cellular respiration (GO:0043457)3.41475329
63ubiquinone metabolic process (GO:0006743)3.38905304
64platelet dense granule organization (GO:0060155)3.34288234
65cardiac muscle contraction (GO:0060048)3.30232167
66sarcoplasmic reticulum calcium ion transport (GO:0070296)3.24842828
67protein targeting to mitochondrion (GO:0006626)3.22954902
68regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.20029757
69cardiac myofibril assembly (GO:0055003)3.19589116
70establishment of protein localization to mitochondrion (GO:0072655)3.19248391
71cytochrome complex assembly (GO:0017004)3.18741657
72DNA damage response, detection of DNA damage (GO:0042769)3.18139145
73regulation of helicase activity (GO:0051095)3.17551140
74respiratory chain complex IV assembly (GO:0008535)3.16690340
75negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.16636979
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14134210
77ribosomal large subunit biogenesis (GO:0042273)3.13159107
78protein localization to mitochondrion (GO:0070585)3.10378150
79myofibril assembly (GO:0030239)3.08475087
80translational elongation (GO:0006414)3.08218063
81negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.07184563
82translation (GO:0006412)3.06867326
83oxaloacetate metabolic process (GO:0006107)3.06695390
84regulation of skeletal muscle contraction (GO:0014819)3.02845371
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01714499
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01714499
87UTP biosynthetic process (GO:0006228)3.01414204
88actin-mediated cell contraction (GO:0070252)3.00919181
89regulation of actin filament-based movement (GO:1903115)2.99748227
90purine ribonucleoside biosynthetic process (GO:0046129)2.99492422
91purine nucleoside biosynthetic process (GO:0042451)2.99492422
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98870947
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96356723
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95205208
95cullin deneddylation (GO:0010388)2.95186633
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93585770
97regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91107856
98regulation of cellular amino acid metabolic process (GO:0006521)2.87169600
99substantia nigra development (GO:0021762)2.84568475
100translational initiation (GO:0006413)2.84037524
101negative regulation of ligase activity (GO:0051352)2.81565091
102negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81565091
103branched-chain amino acid catabolic process (GO:0009083)2.81175964
104proteasome assembly (GO:0043248)2.80235474
105UTP metabolic process (GO:0046051)2.79310822
106nucleoside diphosphate phosphorylation (GO:0006165)2.79074616
107guanosine-containing compound biosynthetic process (GO:1901070)2.79067105
108negative regulation of potassium ion transmembrane transport (GO:1901380)2.78026347
109cardiac muscle tissue morphogenesis (GO:0055008)2.77988777
110regulation of sarcomere organization (GO:0060297)2.76764108
111cellular protein complex disassembly (GO:0043624)2.76664833
112viral life cycle (GO:0019058)2.76319548
113aldehyde catabolic process (GO:0046185)2.75371957
114cellular ketone body metabolic process (GO:0046950)2.74961189
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74413374
116regulation of sulfur metabolic process (GO:0042762)2.73803513
117ribonucleoside monophosphate biosynthetic process (GO:0009156)2.73778316
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71952151
119regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.71443907
120striated muscle contraction (GO:0006941)2.70277381
121water-soluble vitamin biosynthetic process (GO:0042364)2.69554299
122protein deneddylation (GO:0000338)2.69385471
123protein-cofactor linkage (GO:0018065)2.68537341
124signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64065465
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64065465
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64065465
127intracellular protein transmembrane import (GO:0044743)2.62701754
128signal peptide processing (GO:0006465)2.62666513
129termination of RNA polymerase III transcription (GO:0006386)2.62543969
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.62543969
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62296371
132intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62296371
133CENP-A containing nucleosome assembly (GO:0034080)2.61925204
134dopamine transport (GO:0015872)2.61190892
135response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.61062902
136quinone metabolic process (GO:1901661)2.60985005
137regulation of striated muscle contraction (GO:0006942)2.60559581
138negative regulation of heart rate (GO:0010459)2.60138290
139response to epinephrine (GO:0071871)2.58359982
140positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.58184178
141aspartate family amino acid catabolic process (GO:0009068)2.57698114
142cellular component biogenesis (GO:0044085)2.54043787
143intraciliary transport (GO:0042073)2.52849814
144signal transduction involved in DNA damage checkpoint (GO:0072422)2.51293765
145signal transduction involved in DNA integrity checkpoint (GO:0072401)2.51293765
146glutathione derivative biosynthetic process (GO:1901687)2.51218297
147glutathione derivative metabolic process (GO:1901685)2.51218297
148chromatin remodeling at centromere (GO:0031055)2.50780950
149resolution of meiotic recombination intermediates (GO:0000712)2.50416380
150signal transduction involved in cell cycle checkpoint (GO:0072395)2.49509139
151mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.4865937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.04590737
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.80517069
3EZH2_22144423_ChIP-Seq_EOC_Human3.69850195
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.16068865
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07911230
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.02357411
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96837410
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.96643956
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72492186
10* EST1_17652178_ChIP-ChIP_JURKAT_Human2.57890819
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48542709
12VDR_22108803_ChIP-Seq_LS180_Human2.40998060
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36204175
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30265860
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.26635791
16* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24715440
17TAF15_26573619_Chip-Seq_HEK293_Human2.18878082
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.15877122
19IGF1R_20145208_ChIP-Seq_DFB_Human2.14756773
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08222888
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06332064
22* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95891090
23EWS_26573619_Chip-Seq_HEK293_Human1.93404771
24GBX2_23144817_ChIP-Seq_PC3_Human1.81433281
25* YY1_21170310_ChIP-Seq_MESCs_Mouse1.63265141
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62349405
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.57409720
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56925463
29* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50415777
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50248645
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50047798
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45488601
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45222644
34FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.44014079
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42777805
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41341404
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40262878
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39525702
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38778646
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38492907
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.38250454
42DCP1A_22483619_ChIP-Seq_HELA_Human1.37461359
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35525469
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34338529
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34234794
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32474374
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31171661
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.30229464
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29333630
50ER_23166858_ChIP-Seq_MCF-7_Human1.29327125
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28625268
52* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24362196
53FUS_26573619_Chip-Seq_HEK293_Human1.24008635
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24001966
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22774461
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21087157
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19619882
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17613652
59TP53_22573176_ChIP-Seq_HFKS_Human1.17401171
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17273313
61CBP_20019798_ChIP-Seq_JUKART_Human1.17109212
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17109212
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.14606262
64P300_19829295_ChIP-Seq_ESCs_Human1.13800213
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13123564
66* MYC_18555785_ChIP-Seq_MESCs_Mouse1.10773556
67* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10299123
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09470202
69HTT_18923047_ChIP-ChIP_STHdh_Human1.08789454
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07690785
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07636286
72* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07560962
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07465257
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06799581
75ZNF274_21170338_ChIP-Seq_K562_Hela1.06586145
76ELK1_19687146_ChIP-ChIP_HELA_Human1.06533361
77* VDR_23849224_ChIP-Seq_CD4+_Human1.06225945
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.05922829
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05566659
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05564218
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05131533
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04552181
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.03664092
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03628487
85IRF1_19129219_ChIP-ChIP_H3396_Human1.03555730
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.03540738
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03540738
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03196660
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03136603
90GABP_19822575_ChIP-Seq_HepG2_Human1.01820134
91AR_20517297_ChIP-Seq_VCAP_Human1.01056546
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00898596
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00345823
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99431972
95TCF4_22108803_ChIP-Seq_LS180_Human0.99322728
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99316035
97EED_16625203_ChIP-ChIP_MESCs_Mouse0.98804456
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.98783316
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98747944
100REST_18959480_ChIP-ChIP_MESCs_Mouse0.97913772
101NFE2_27457419_Chip-Seq_LIVER_Mouse0.97642195
102BCAT_22108803_ChIP-Seq_LS180_Human0.97346455
103JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97240675
104KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96949991
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96903296
106RNF2_27304074_Chip-Seq_NSC_Mouse0.96033445
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96007647
108MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95554154
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95444145
110CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95054934
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95019032
112AR_25329375_ChIP-Seq_VCAP_Human0.94754284
113* SALL4_22934838_ChIP-ChIP_CD34+_Human0.94553025
114SMAD4_21799915_ChIP-Seq_A2780_Human0.94051271
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.93324997
116CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92676874
117FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92588517
118REST_21632747_ChIP-Seq_MESCs_Mouse0.92518884
119TTF2_22483619_ChIP-Seq_HELA_Human0.91336287
120MYC_18940864_ChIP-ChIP_HL60_Human0.91239125
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91093182
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90812983
123MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90637689
124FOXP3_21729870_ChIP-Seq_TREG_Human0.90493328
125SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89881846
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89798412
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89152176
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87493917
129EZH2_27294783_Chip-Seq_ESCs_Mouse0.86930345
130MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86537564
131SOX2_19829295_ChIP-Seq_ESCs_Human0.85217370
132NANOG_19829295_ChIP-Seq_ESCs_Human0.85217370
133REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83499044
134EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82668728
135RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82668728
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82058917
137NCOR_22424771_ChIP-Seq_293T_Human0.81948837
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80131364
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79882308
140* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79080236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.14078022
2MP0003646_muscle_fatigue4.40810194
3MP0000751_myopathy3.60307997
4MP0004215_abnormal_myocardial_fiber3.58221701
5MP0004084_abnormal_cardiac_muscle3.31813784
6MP0006036_abnormal_mitochondrial_physio3.24129494
7MP0003880_abnormal_central_pattern3.21146148
8MP0004036_abnormal_muscle_relaxation3.11332116
9MP0000749_muscle_degeneration3.05769848
10MP0001529_abnormal_vocalization2.89194151
11MP0005330_cardiomyopathy2.69194204
12MP0004145_abnormal_muscle_electrophysio2.44987105
13MP0006035_abnormal_mitochondrial_morpho2.26556989
14MP0006276_abnormal_autonomic_nervous2.20260899
15MP0002972_abnormal_cardiac_muscle2.18752543
16MP0009379_abnormal_foot_pigmentation2.17232046
17MP0004484_altered_response_of2.15367792
18MP0003137_abnormal_impulse_conducting2.11625211
19MP0005620_abnormal_muscle_contractility2.02458539
20MP0002332_abnormal_exercise_endurance1.88405606
21MP0001905_abnormal_dopamine_level1.82311848
22MP0004142_abnormal_muscle_tone1.76362889
23MP0008775_abnormal_heart_ventricle1.73055570
24MP0002106_abnormal_muscle_physiology1.70181647
25MP0004043_abnormal_pH_regulation1.66963306
26MP0002938_white_spotting1.66444863
27MP0002102_abnormal_ear_morphology1.64380170
28MP0004087_abnormal_muscle_fiber1.61421657
29MP0005379_endocrine/exocrine_gland_phen1.59621466
30MP0004085_abnormal_heartbeat1.58399911
31MP0001544_abnormal_cardiovascular_syste1.57086833
32MP0005385_cardiovascular_system_phenoty1.57086833
33MP0009046_muscle_twitch1.57006225
34MP0003950_abnormal_plasma_membrane1.56528699
35MP0006138_congestive_heart_failure1.53441967
36MP0002234_abnormal_pharynx_morphology1.51716190
37MP0002736_abnormal_nociception_after1.49083307
38MP0003718_maternal_effect1.47765040
39MP0003806_abnormal_nucleotide_metabolis1.46174335
40MP0004130_abnormal_muscle_cell1.46116852
41MP0009745_abnormal_behavioral_response1.45390099
42MP0008058_abnormal_DNA_repair1.44255350
43MP0000750_abnormal_muscle_regeneration1.43346182
44MP0001968_abnormal_touch/_nociception1.42555185
45MP0005369_muscle_phenotype1.42423002
46MP0000747_muscle_weakness1.40217528
47MP0002064_seizures1.40086907
48MP0005253_abnormal_eye_physiology1.39854794
49MP0005408_hypopigmentation1.39766675
50MP0002272_abnormal_nervous_system1.39741566
51MP0008877_abnormal_DNA_methylation1.39155232
52MP0003122_maternal_imprinting1.37168669
53MP0001440_abnormal_grooming_behavior1.35475587
54MP0002822_catalepsy1.34609298
55MP0003195_calcinosis1.33454067
56MP0005386_behavior/neurological_phenoty1.30711699
57MP0004924_abnormal_behavior1.30711699
58MP0003221_abnormal_cardiomyocyte_apopto1.28292966
59MP0003011_delayed_dark_adaptation1.26870336
60MP0000631_abnormal_neuroendocrine_gland1.24805040
61MP0010030_abnormal_orbit_morphology1.24684248
62MP0004133_heterotaxia1.23370702
63MP0002127_abnormal_cardiovascular_syste1.23070430
64MP0002269_muscular_atrophy1.22819808
65MP0005171_absent_coat_pigmentation1.22634414
66MP0002090_abnormal_vision1.21815590
67MP0008789_abnormal_olfactory_epithelium1.19840026
68MP0000759_abnormal_skeletal_muscle1.17170699
69MP0002139_abnormal_hepatobiliary_system1.16718880
70MP0002638_abnormal_pupillary_reflex1.15867487
71MP0005266_abnormal_metabolism1.14869267
72MP0003635_abnormal_synaptic_transmissio1.10763566
73MP0003136_yellow_coat_color1.10477764
74MP0001984_abnormal_olfaction1.08927104
75MP0001346_abnormal_lacrimal_gland1.08910876
76MP0002735_abnormal_chemical_nociception1.08345708
77MP0009697_abnormal_copulation1.08252517
78MP0002572_abnormal_emotion/affect_behav1.07191579
79MP0003186_abnormal_redox_activity1.07076985
80MP0000230_abnormal_systemic_arterial1.06775512
81MP0005248_abnormal_Harderian_gland1.06694120
82MP0005332_abnormal_amino_acid1.06632287
83MP0005075_abnormal_melanosome_morpholog1.06340839
84MP0005535_abnormal_body_temperature1.05741553
85MP0004147_increased_porphyrin_level1.03815259
86MP0002734_abnormal_mechanical_nocicepti1.03192095
87MP0002095_abnormal_skin_pigmentation1.03108433
88MP0002067_abnormal_sensory_capabilities1.03092964
89MP0005451_abnormal_body_composition1.01874716
90MP0001486_abnormal_startle_reflex1.01609388
91MP0005165_increased_susceptibility_to0.97773104
92MP0008875_abnormal_xenobiotic_pharmacok0.97484143
93MP0005084_abnormal_gallbladder_morpholo0.97071789
94MP0002876_abnormal_thyroid_physiology0.96905372
95MP0010630_abnormal_cardiac_muscle0.96266814
96MP0005085_abnormal_gallbladder_physiolo0.96065448
97MP0001485_abnormal_pinna_reflex0.95293848
98MP0008004_abnormal_stomach_pH0.92677984
99MP0003890_abnormal_embryonic-extraembry0.91277042
100MP0008995_early_reproductive_senescence0.89623570
101MP0005423_abnormal_somatic_nervous0.89453973
102MP0001324_abnormal_eye_pigmentation0.89289572
103MP0005646_abnormal_pituitary_gland0.88928769
104MP0000013_abnormal_adipose_tissue0.88422902
105MP0002063_abnormal_learning/memory/cond0.88186740
106MP0003567_abnormal_fetal_cardiomyocyte0.88152182
107MP0001764_abnormal_homeostasis0.87394426
108MP0003787_abnormal_imprinting0.87020504
109MP0004957_abnormal_blastocyst_morpholog0.85956328
110MP0001970_abnormal_pain_threshold0.84468183
111MP0004233_abnormal_muscle_weight0.81434233
112MP0000647_abnormal_sebaceous_gland0.81386620
113MP0005360_urolithiasis0.79832826
114MP0004885_abnormal_endolymph0.78043374
115MP0005195_abnormal_posterior_eye0.77512635
116MP0005551_abnormal_eye_electrophysiolog0.77199040
117MP0002233_abnormal_nose_morphology0.76845861
118MP0004270_analgesia0.76745364
119MP0005584_abnormal_enzyme/coenzyme_acti0.76538105
120MP0005636_abnormal_mineral_homeostasis0.76460418
121MP0001501_abnormal_sleep_pattern0.75930455
122MP0003941_abnormal_skin_development0.75690622
123MP0003828_pulmonary_edema0.75038732
124MP0004510_myositis0.73042424
125MP0002163_abnormal_gland_morphology0.72665871
126MP0001727_abnormal_embryo_implantation0.71713117
127MP0005376_homeostasis/metabolism_phenot0.71257709
128MP0001661_extended_life_span0.71161654
129MP0006072_abnormal_retinal_apoptosis0.69851540
130MP0002210_abnormal_sex_determination0.69777260
131MP0005499_abnormal_olfactory_system0.69276673
132MP0005394_taste/olfaction_phenotype0.69276673
133MP0000372_irregular_coat_pigmentation0.68666659
134MP0008872_abnormal_physiological_respon0.67843713
135MP0002066_abnormal_motor_capabilities/c0.67475475
136MP0005645_abnormal_hypothalamus_physiol0.66570969
137MP0010386_abnormal_urinary_bladder0.65183674

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.56523355
2Abnormal mitochondria in muscle tissue (HP:0008316)7.08283875
3Mitochondrial inheritance (HP:0001427)6.47100421
4Progressive macrocephaly (HP:0004481)6.45477573
5Acute encephalopathy (HP:0006846)6.43687758
6Hepatocellular necrosis (HP:0001404)5.77981533
7Increased CSF lactate (HP:0002490)5.74754039
8Hepatic necrosis (HP:0002605)5.53441953
9Cerebral edema (HP:0002181)4.99012353
10Increased hepatocellular lipid droplets (HP:0006565)4.53499954
11Abnormality of glycolysis (HP:0004366)4.38729522
12Increased serum pyruvate (HP:0003542)4.38729522
13Lipid accumulation in hepatocytes (HP:0006561)4.34208535
14Exercise intolerance (HP:0003546)4.25049210
15Respiratory failure (HP:0002878)4.19813122
16Lactic acidosis (HP:0003128)4.18590011
17Increased intramyocellular lipid droplets (HP:0012240)4.10171357
18Muscle hypertrophy of the lower extremities (HP:0008968)3.85578607
19Calf muscle hypertrophy (HP:0008981)3.84831231
20Increased muscle lipid content (HP:0009058)3.84480864
21Optic disc pallor (HP:0000543)3.83995732
22Sudden death (HP:0001699)3.79809768
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.76155593
24Leukodystrophy (HP:0002415)3.68162877
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.66903667
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.66903667
27Increased serum lactate (HP:0002151)3.61283440
28Renal Fanconi syndrome (HP:0001994)3.60698305
29Pheochromocytoma (HP:0002666)3.39332111
30Neuroendocrine neoplasm (HP:0100634)3.36407003
31Exercise-induced myalgia (HP:0003738)3.36033964
32Exercise-induced muscle cramps (HP:0003710)3.17206319
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.14606047
343-Methylglutaconic aciduria (HP:0003535)3.09911398
35Palpitations (HP:0001962)2.99642137
36Ventricular tachycardia (HP:0004756)2.92175136
37Myoglobinuria (HP:0002913)2.87641869
38Lethargy (HP:0001254)2.84136567
39Abnormality of the calf musculature (HP:0001430)2.81458497
40CNS demyelination (HP:0007305)2.75965166
41Respiratory difficulties (HP:0002880)2.69519040
42Atrial fibrillation (HP:0005110)2.68036744
43Exertional dyspnea (HP:0002875)2.64889953
44Conjunctival hamartoma (HP:0100780)2.62879998
45Rhabdomyolysis (HP:0003201)2.59751393
46True hermaphroditism (HP:0010459)2.57135147
47Congenital, generalized hypertrichosis (HP:0004540)2.56155756
48Abnormality of urine glucose concentration (HP:0011016)2.54463492
49Glycosuria (HP:0003076)2.54463492
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51975280
51Dicarboxylic aciduria (HP:0003215)2.51975280
52Supraventricular tachycardia (HP:0004755)2.51511333
53Primary atrial arrhythmia (HP:0001692)2.51299759
54Abnormality of alanine metabolism (HP:0010916)2.49674579
55Hyperalaninemia (HP:0003348)2.49674579
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49674579
57Syncope (HP:0001279)2.47093690
58X-linked dominant inheritance (HP:0001423)2.44778481
59Supraventricular arrhythmia (HP:0005115)2.42127449
60Pancreatic cysts (HP:0001737)2.42032235
61Macrocytic anemia (HP:0001972)2.41175884
62Pancreatic fibrosis (HP:0100732)2.40588061
63Molar tooth sign on MRI (HP:0002419)2.40203180
64Abnormality of midbrain morphology (HP:0002418)2.40203180
65Lipoatrophy (HP:0100578)2.40052860
66Muscle fiber splitting (HP:0003555)2.38367949
67Abnormality of renal resorption (HP:0011038)2.37759485
68Emotional lability (HP:0000712)2.35067312
69Focal motor seizures (HP:0011153)2.30230040
70Prolonged QT interval (HP:0001657)2.29468359
71Abnormal number of erythroid precursors (HP:0012131)2.28946041
72Abnormality of methionine metabolism (HP:0010901)2.27911956
73Ragged-red muscle fibers (HP:0003200)2.26690986
74Medial flaring of the eyebrow (HP:0010747)2.25184866
75Methylmalonic aciduria (HP:0012120)2.23270564
76Dilated cardiomyopathy (HP:0001644)2.22537362
77Type I transferrin isoform profile (HP:0003642)2.22120423
78Abnormality of cells of the erythroid lineage (HP:0012130)2.21722477
79Vomiting (HP:0002013)2.15360411
80Abnormality of fatty-acid metabolism (HP:0004359)2.14942950
81Ketoacidosis (HP:0001993)2.11738763
82Muscle stiffness (HP:0003552)2.11262044
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11136802
84Myotonia (HP:0002486)2.07287974
85EMG: myopathic abnormalities (HP:0003458)2.04968158
86Renal cortical cysts (HP:0000803)2.04934598
87Nephronophthisis (HP:0000090)2.04442092
88Methylmalonic acidemia (HP:0002912)2.02479563
89Colon cancer (HP:0003003)2.02078575
90Left ventricular hypertrophy (HP:0001712)2.01117592
91Gliosis (HP:0002171)2.00090753
92Hyperphosphaturia (HP:0003109)1.99855391
93Ventricular fibrillation (HP:0001663)1.98740002
94Esophageal neoplasm (HP:0100751)1.95031242
95Neoplasm of head and neck (HP:0012288)1.95031242
96Hyperglycinemia (HP:0002154)1.94704923
97Reticulocytopenia (HP:0001896)1.94478744
98Generalized aminoaciduria (HP:0002909)1.92975981
99Degeneration of anterior horn cells (HP:0002398)1.89177211
100Abnormality of the anterior horn cell (HP:0006802)1.89177211
101Sclerocornea (HP:0000647)1.88635008
102Hypoglycemic coma (HP:0001325)1.87199587
103Metabolic acidosis (HP:0001942)1.85659055
104Hyperglycinuria (HP:0003108)1.85239003
105Abnormality of serum amino acid levels (HP:0003112)1.84565719
106Cerebral hemorrhage (HP:0001342)1.83665457
107Ventricular arrhythmia (HP:0004308)1.83647336
108Ketosis (HP:0001946)1.82745928
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82273047
110Male pseudohermaphroditism (HP:0000037)1.80926561
111Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80884907
112Muscle fiber inclusion bodies (HP:0100299)1.80641850
113Abnormal protein glycosylation (HP:0012346)1.80316694
114Abnormal glycosylation (HP:0012345)1.80316694
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80316694
116Abnormal protein N-linked glycosylation (HP:0012347)1.80316694
117Myokymia (HP:0002411)1.79551460
118Abnormal EKG (HP:0003115)1.79113000
119Esophageal atresia (HP:0002032)1.78247743
120Progressive external ophthalmoplegia (HP:0000590)1.77410884
121Hyperinsulinemic hypoglycemia (HP:0000825)1.76497674
122Abnormality of the renal cortex (HP:0011035)1.76348291
123Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75519002
124Gait imbalance (HP:0002141)1.75125633
125Aplasia/hypoplasia of the uterus (HP:0008684)1.74952253
126Abnormal ciliary motility (HP:0012262)1.74489038
127Microvesicular hepatic steatosis (HP:0001414)1.73994421
128Congenital primary aphakia (HP:0007707)1.73599491
129Abnormality of the labia minora (HP:0012880)1.71961350
130Hypoplastic left heart (HP:0004383)1.70452739
131Reduced antithrombin III activity (HP:0001976)1.70436205
132Abnormality of vitamin B metabolism (HP:0004340)1.70194360
133Hypoplasia of the fovea (HP:0007750)1.70043843
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.70043843
135Hyperammonemia (HP:0001987)1.69908146
136Neoplasm of the adrenal gland (HP:0100631)1.69800953
137Nemaline bodies (HP:0003798)1.69787737
138Stenosis of the external auditory canal (HP:0000402)1.69575329
139Hyperventilation (HP:0002883)1.69389217
140Blindness (HP:0000618)1.68925043
141Hyporeflexia of lower limbs (HP:0002600)1.66965944
142Abnormality of the fovea (HP:0000493)1.66857032
143Rimmed vacuoles (HP:0003805)1.66390143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.87314812
2NME13.72627926
3MYLK3.67544189
4MAP3K123.21203816
5VRK23.09196399
6PDK32.79493194
7PDK42.79493194
8BCKDK2.62738687
9TAOK22.59545128
10STK392.51052180
11NME22.47305783
12STK162.42123085
13GRK72.36888199
14FRK2.33409755
15PHKG22.25108475
16PHKG12.25108475
17MAP4K22.22229669
18WNK42.15028899
19ACVR1B2.08674823
20MUSK1.95505789
21CASK1.90407473
22PDK21.89018014
23ARAF1.86516457
24OXSR11.83812723
25LMTK21.83126218
26MST41.80414813
27CDK191.73772683
28PBK1.65749256
29MAP2K71.60257134
30NUAK11.56323599
31TTN1.55709331
32PINK11.51281295
33ERBB31.48762163
34STK241.42580826
35TLK11.33557399
36BCR1.32998512
37CAMK2D1.25998181
38TIE11.25642274
39TRIM281.24749019
40PLK31.24668544
41GRK51.22324122
42PNCK1.20361844
43MAP3K41.19951277
44CSNK1G21.13264422
45TAF11.13245674
46MAP2K41.11263277
47ADRBK21.10024070
48CSNK1G11.09085620
49CAMK2A1.08750598
50TTK1.06282066
51ILK1.06070162
52LIMK11.02683535
53BUB11.02482162
54CAMK2G0.98244713
55NEK10.96815964
56PIK3CA0.96745952
57BRAF0.95765717
58VRK10.94320998
59CAMK2B0.90592376
60DAPK30.90096194
61CSNK1A1L0.89419708
62PLK20.88666363
63WNK30.86995848
64FGFR20.85486722
65ADRBK10.85011362
66EIF2AK10.82263220
67PKN10.82118153
68STK38L0.81380681
69ZAK0.79980986
70TNIK0.79079792
71PLK40.78529506
72PIK3CG0.78361842
73EPHA40.75158142
74BRSK20.72711667
75PRKCE0.72455141
76TGFBR10.71648746
77BMPR20.71215267
78PLK10.68781560
79PRKACA0.68439706
80ABL20.68124631
81ROCK20.68069449
82CCNB10.67919904
83NTRK30.66336960
84PAK30.65411295
85MAPKAPK30.64786664
86MAPK120.64627660
87PRPF4B0.62333781
88BMPR1B0.60961808
89UHMK10.60174429
90MST1R0.59410998
91MAPK130.58003566
92MKNK10.56394953
93PRKCG0.56022731
94EIF2AK30.55906654
95MINK10.52982276
96EIF2AK20.52925313
97PTK2B0.51204463
98MAP3K110.50862850
99MAP2K60.47158037
100CAMKK20.45025652
101CSNK2A20.44575309
102MAPKAPK50.44427749
103NTRK20.44320194
104RPS6KB20.42652415
105ROCK10.42111868
106AURKB0.41270615
107CDC70.40038746
108MAP3K50.40009167
109MARK10.39813028
110DYRK20.39133609
111TSSK60.38011301
112WEE10.37188765
113CSNK1A10.37093486
114CHEK20.36878421
115INSRR0.36531620
116PASK0.36436274
117IRAK20.35692673
118CDK80.35312325
119PRKCQ0.35184598
120PRKACB0.35060918
121KDR0.34401016
122BRSK10.34311271
123PRKG10.32363596
124WNK10.30599212
125CSNK1G30.30337246
126CSNK2A10.30001600
127DAPK10.29352044
128CAMK10.28252260
129SRPK10.27976761
130PRKCA0.27952661
131GRK10.27022375
132PRKACG0.26691557

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.36142919
2Parkinsons disease_Homo sapiens_hsa050125.57067504
3Alzheimers disease_Homo sapiens_hsa050104.13505726
4Huntingtons disease_Homo sapiens_hsa050163.89415670
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.88335492
6Cardiac muscle contraction_Homo sapiens_hsa042603.55644766
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.50105181
8Propanoate metabolism_Homo sapiens_hsa006402.52840415
9Ribosome_Homo sapiens_hsa030102.43725360
10Proteasome_Homo sapiens_hsa030502.37770574
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23567513
12Fatty acid elongation_Homo sapiens_hsa000622.03078791
13Pyruvate metabolism_Homo sapiens_hsa006202.02531698
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02310722
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73577987
16Carbon metabolism_Homo sapiens_hsa012001.72567484
17Collecting duct acid secretion_Homo sapiens_hsa049661.65882884
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63893941
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.60966736
20Protein export_Homo sapiens_hsa030601.58729425
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55045716
22Homologous recombination_Homo sapiens_hsa034401.53092569
23Mismatch repair_Homo sapiens_hsa034301.50134604
24Butanoate metabolism_Homo sapiens_hsa006501.48978102
25Fatty acid degradation_Homo sapiens_hsa000711.39325848
26Sulfur metabolism_Homo sapiens_hsa009201.28190606
27RNA polymerase_Homo sapiens_hsa030201.27134518
28Basal transcription factors_Homo sapiens_hsa030221.25185323
29Nucleotide excision repair_Homo sapiens_hsa034201.18199614
30Fatty acid metabolism_Homo sapiens_hsa012121.16895418
31RNA degradation_Homo sapiens_hsa030181.14604286
32One carbon pool by folate_Homo sapiens_hsa006701.10671763
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03098670
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99471876
35Vibrio cholerae infection_Homo sapiens_hsa051100.99189960
36Caffeine metabolism_Homo sapiens_hsa002320.97502784
37Nitrogen metabolism_Homo sapiens_hsa009100.96680064
38Fanconi anemia pathway_Homo sapiens_hsa034600.95821222
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95529518
40Peroxisome_Homo sapiens_hsa041460.91809430
41* Metabolic pathways_Homo sapiens_hsa011000.90030163
42Dilated cardiomyopathy_Homo sapiens_hsa054140.89801977
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89783585
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.85159902
45Nicotine addiction_Homo sapiens_hsa050330.84792060
46DNA replication_Homo sapiens_hsa030300.83617025
47Phenylalanine metabolism_Homo sapiens_hsa003600.79519145
48Synaptic vesicle cycle_Homo sapiens_hsa047210.77034145
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75820062
50Biosynthesis of amino acids_Homo sapiens_hsa012300.74485375
51Tyrosine metabolism_Homo sapiens_hsa003500.72207322
52beta-Alanine metabolism_Homo sapiens_hsa004100.71924203
53RNA transport_Homo sapiens_hsa030130.71231877
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65644613
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64893342
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.61092691
57Arginine and proline metabolism_Homo sapiens_hsa003300.60901978
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60122323
59Spliceosome_Homo sapiens_hsa030400.58398917
60Glutathione metabolism_Homo sapiens_hsa004800.58067819
61Pyrimidine metabolism_Homo sapiens_hsa002400.57942192
62Circadian rhythm_Homo sapiens_hsa047100.57309669
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57192231
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.57095651
65Base excision repair_Homo sapiens_hsa034100.55627372
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.55017773
67Tryptophan metabolism_Homo sapiens_hsa003800.54067136
68GABAergic synapse_Homo sapiens_hsa047270.53420529
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53115768
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53002362
71Non-homologous end-joining_Homo sapiens_hsa034500.52643557
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51209616
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51001864
74Oocyte meiosis_Homo sapiens_hsa041140.50262057
75Purine metabolism_Homo sapiens_hsa002300.49583456
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49303692
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48794699
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46999181
79Calcium signaling pathway_Homo sapiens_hsa040200.45346606
80Mineral absorption_Homo sapiens_hsa049780.43911822
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43514496
82PPAR signaling pathway_Homo sapiens_hsa033200.43364747
83Starch and sucrose metabolism_Homo sapiens_hsa005000.41968865
84Taste transduction_Homo sapiens_hsa047420.41429795
85Fructose and mannose metabolism_Homo sapiens_hsa000510.40683194
86Selenocompound metabolism_Homo sapiens_hsa004500.38383842
87Morphine addiction_Homo sapiens_hsa050320.38002228
88Serotonergic synapse_Homo sapiens_hsa047260.37966452
89Vitamin digestion and absorption_Homo sapiens_hsa049770.37296021
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36888255
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36199040
92Rheumatoid arthritis_Homo sapiens_hsa053230.36084001
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35620852
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35239448
95Galactose metabolism_Homo sapiens_hsa000520.31096183
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31024178
97Arachidonic acid metabolism_Homo sapiens_hsa005900.30946575
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30816251
99Phototransduction_Homo sapiens_hsa047440.29894229
100Asthma_Homo sapiens_hsa053100.27836890
101Folate biosynthesis_Homo sapiens_hsa007900.27189628
102Pentose phosphate pathway_Homo sapiens_hsa000300.26928016
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26914849
104Circadian entrainment_Homo sapiens_hsa047130.26808727
105Chemical carcinogenesis_Homo sapiens_hsa052040.25955992
106Histidine metabolism_Homo sapiens_hsa003400.25254938
107Arginine biosynthesis_Homo sapiens_hsa002200.24476881
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.20352144
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19559761
110Sulfur relay system_Homo sapiens_hsa041220.19506850
111Dopaminergic synapse_Homo sapiens_hsa047280.18952933
112Olfactory transduction_Homo sapiens_hsa047400.17629783
113Renin secretion_Homo sapiens_hsa049240.17595480
114Glucagon signaling pathway_Homo sapiens_hsa049220.17063135
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16854805
116Amphetamine addiction_Homo sapiens_hsa050310.15977419
117Gastric acid secretion_Homo sapiens_hsa049710.15903988
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.15694271
119Linoleic acid metabolism_Homo sapiens_hsa005910.14397455
120Glutamatergic synapse_Homo sapiens_hsa047240.14008432
121Steroid biosynthesis_Homo sapiens_hsa001000.12490707
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.12367442
123Ether lipid metabolism_Homo sapiens_hsa005650.11274295
124Regulation of autophagy_Homo sapiens_hsa041400.11137833
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10816524
126Vitamin B6 metabolism_Homo sapiens_hsa007500.10669512
127Insulin secretion_Homo sapiens_hsa049110.10475563
128Retinol metabolism_Homo sapiens_hsa008300.10383207
129Fat digestion and absorption_Homo sapiens_hsa049750.08569069

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