

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 9.99113031 |
| 2 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 9.26455714 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 9.26455714 |
| 4 | * mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 8.37763098 |
| 5 | * respiratory electron transport chain (GO:0022904) | 8.07489262 |
| 6 | * electron transport chain (GO:0022900) | 7.86908191 |
| 7 | tricarboxylic acid cycle (GO:0006099) | 6.62791121 |
| 8 | oxidative phosphorylation (GO:0006119) | 6.56646844 |
| 9 | ATP biosynthetic process (GO:0006754) | 5.49876749 |
| 10 | NADH metabolic process (GO:0006734) | 5.45455021 |
| 11 | protein complex biogenesis (GO:0070271) | 5.35181244 |
| 12 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 5.29597514 |
| 13 | NADH dehydrogenase complex assembly (GO:0010257) | 5.29597514 |
| 14 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 5.29597514 |
| 15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.96422613 |
| 16 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 4.92489998 |
| 17 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.88807012 |
| 18 | hydrogen ion transmembrane transport (GO:1902600) | 4.80747133 |
| 19 | sarcomere organization (GO:0045214) | 4.49346729 |
| 20 | heart process (GO:0003015) | 4.47667549 |
| 21 | heart contraction (GO:0060047) | 4.47667549 |
| 22 | inner mitochondrial membrane organization (GO:0007007) | 4.46217863 |
| 23 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 4.41313535 |
| 24 | aerobic respiration (GO:0009060) | 4.39388316 |
| 25 | succinate metabolic process (GO:0006105) | 4.39265682 |
| 26 | chaperone-mediated protein transport (GO:0072321) | 4.38037951 |
| 27 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 4.37104224 |
| 28 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.30111125 |
| 29 | muscle filament sliding (GO:0030049) | 4.29836751 |
| 30 | actin-myosin filament sliding (GO:0033275) | 4.29836751 |
| 31 | regulation of mitochondrial translation (GO:0070129) | 4.21661435 |
| 32 | proton transport (GO:0015992) | 4.15531318 |
| 33 | ribosomal small subunit assembly (GO:0000028) | 4.14746891 |
| 34 | hydrogen transport (GO:0006818) | 4.09525874 |
| 35 | regulation of coenzyme metabolic process (GO:0051196) | 4.06248882 |
| 36 | regulation of cofactor metabolic process (GO:0051193) | 4.06248882 |
| 37 | regulation of oxidative phosphorylation (GO:0002082) | 4.00908280 |
| 38 | viral transcription (GO:0019083) | 3.94887396 |
| 39 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.94831946 |
| 40 | quinone biosynthetic process (GO:1901663) | 3.93936312 |
| 41 | ubiquinone biosynthetic process (GO:0006744) | 3.93936312 |
| 42 | oxaloacetate metabolic process (GO:0006107) | 3.92068192 |
| 43 | cardiac myofibril assembly (GO:0055003) | 3.90104514 |
| 44 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.84791693 |
| 45 | DNA deamination (GO:0045006) | 3.84131878 |
| 46 | cotranslational protein targeting to membrane (GO:0006613) | 3.81665673 |
| 47 | translational termination (GO:0006415) | 3.81269512 |
| 48 | termination of RNA polymerase III transcription (GO:0006386) | 3.81097080 |
| 49 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.81097080 |
| 50 | protein targeting to ER (GO:0045047) | 3.78238044 |
| 51 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 3.78017565 |
| 52 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 3.78017565 |
| 53 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.72669151 |
| 54 | cytochrome complex assembly (GO:0017004) | 3.69551362 |
| 55 | myofibril assembly (GO:0030239) | 3.65244025 |
| 56 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.64813481 |
| 57 | respiratory chain complex IV assembly (GO:0008535) | 3.64182413 |
| 58 | sequestering of actin monomers (GO:0042989) | 3.63871909 |
| 59 | mitochondrial transport (GO:0006839) | 3.62757807 |
| 60 | protein localization to endoplasmic reticulum (GO:0070972) | 3.62444920 |
| 61 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.61658079 |
| 62 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.58969239 |
| 63 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.58884582 |
| 64 | cullin deneddylation (GO:0010388) | 3.58228762 |
| 65 | cellular respiration (GO:0045333) | 3.58119024 |
| 66 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.57615298 |
| 67 | negative regulation of ligase activity (GO:0051352) | 3.57615298 |
| 68 | cardiac muscle contraction (GO:0060048) | 3.55517386 |
| 69 | protein neddylation (GO:0045116) | 3.55460964 |
| 70 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.52242529 |
| 71 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.52242529 |
| 72 | regulation of cellular respiration (GO:0043457) | 3.50573746 |
| 73 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.50069753 |
| 74 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 3.48854509 |
| 75 | ubiquinone metabolic process (GO:0006743) | 3.48388530 |
| 76 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.47039631 |
| 77 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.47039631 |
| 78 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.47039631 |
| 79 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.45823898 |
| 80 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.45823898 |
| 81 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.44950699 |
| 82 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.44950699 |
| 83 | maturation of SSU-rRNA (GO:0030490) | 3.44597565 |
| 84 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.44545193 |
| 85 | regulation of relaxation of muscle (GO:1901077) | 3.44312036 |
| 86 | actin-mediated cell contraction (GO:0070252) | 3.41956625 |
| 87 | translational elongation (GO:0006414) | 3.41274875 |
| 88 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.40450393 |
| 89 | ribosomal small subunit biogenesis (GO:0042274) | 3.36311850 |
| 90 | protein deneddylation (GO:0000338) | 3.34564989 |
| 91 | * generation of precursor metabolites and energy (GO:0006091) | 3.34094033 |
| 92 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.30408799 |
| 93 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.30408799 |
| 94 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.30153825 |
| 95 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.29684118 |
| 96 | intracellular protein transmembrane import (GO:0044743) | 3.29224638 |
| 97 | translation (GO:0006412) | 3.28035991 |
| 98 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 3.27818719 |
| 99 | protein targeting to mitochondrion (GO:0006626) | 3.25974093 |
| 100 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.25296538 |
| 101 | establishment of protein localization to mitochondrion (GO:0072655) | 3.21166306 |
| 102 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.20799017 |
| 103 | proteasome assembly (GO:0043248) | 3.20119105 |
| 104 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.19505987 |
| 105 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.19028312 |
| 106 | branched-chain amino acid catabolic process (GO:0009083) | 3.16604940 |
| 107 | behavioral response to nicotine (GO:0035095) | 3.13692909 |
| 108 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.13532092 |
| 109 | pseudouridine synthesis (GO:0001522) | 3.13356976 |
| 110 | purine nucleoside biosynthetic process (GO:0042451) | 3.13239224 |
| 111 | purine ribonucleoside biosynthetic process (GO:0046129) | 3.13239224 |
| 112 | ribonucleoside monophosphate biosynthetic process (GO:0009156) | 3.12952805 |
| 113 | rRNA modification (GO:0000154) | 3.11571061 |
| 114 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.11106638 |
| 115 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.08878687 |
| 116 | protein localization to mitochondrion (GO:0070585) | 3.08395775 |
| 117 | platelet dense granule organization (GO:0060155) | 3.08336559 |
| 118 | viral life cycle (GO:0019058) | 3.02355217 |
| 119 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.02203981 |
| 120 | aspartate family amino acid catabolic process (GO:0009068) | 3.00611996 |
| 121 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.98924615 |
| 122 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.98754320 |
| 123 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.98367307 |
| 124 | aldehyde catabolic process (GO:0046185) | 2.97012153 |
| 125 | regulation of sulfur metabolic process (GO:0042762) | 2.96504282 |
| 126 | mannosylation (GO:0097502) | 2.96137324 |
| 127 | positive regulation of ligase activity (GO:0051351) | 2.95689336 |
| 128 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 2.95586645 |
| 129 | regulation of cellular amine metabolic process (GO:0033238) | 2.95556267 |
| 130 | cellular protein complex disassembly (GO:0043624) | 2.95543541 |
| 131 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 2.95243464 |
| 132 | metallo-sulfur cluster assembly (GO:0031163) | 2.94791678 |
| 133 | iron-sulfur cluster assembly (GO:0016226) | 2.94791678 |
| 134 | regulation of cell communication by electrical coupling (GO:0010649) | 2.94332176 |
| 135 | cellular component biogenesis (GO:0044085) | 2.94307216 |
| 136 | nucleoside monophosphate biosynthetic process (GO:0009124) | 2.91983495 |
| 137 | cardiac muscle cell development (GO:0055013) | 2.91906934 |
| 138 | GTP biosynthetic process (GO:0006183) | 2.91636369 |
| 139 | regulation of actin filament-based movement (GO:1903115) | 2.91367293 |
| 140 | translational initiation (GO:0006413) | 2.91135443 |
| 141 | protein-cofactor linkage (GO:0018065) | 2.90830367 |
| 142 | regulation of skeletal muscle contraction (GO:0014819) | 2.88178087 |
| 143 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.86044442 |
| 144 | striated muscle contraction (GO:0006941) | 2.85294183 |
| 145 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 2.85150595 |
| 146 | lysine catabolic process (GO:0006554) | 2.84798337 |
| 147 | lysine metabolic process (GO:0006553) | 2.84798337 |
| 148 | muscle tissue morphogenesis (GO:0060415) | 2.84624395 |
| 149 | spliceosomal snRNP assembly (GO:0000387) | 2.82208047 |
| 150 | DNA damage response, detection of DNA damage (GO:0042769) | 2.81145778 |
| 151 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 2.79272965 |
| 152 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.77360113 |
| 153 | base-excision repair, AP site formation (GO:0006285) | 2.76917383 |
| 154 | 2-oxoglutarate metabolic process (GO:0006103) | 2.73592110 |
| 155 | ribonucleoside biosynthetic process (GO:0042455) | 2.73469329 |
| 156 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.70235180 |
| 157 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.69023360 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.92307124 |
| 2 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.67995740 |
| 3 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.17582125 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.01453740 |
| 5 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.98773869 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.74991855 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.72620276 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.71712895 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.42770724 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.32207063 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.16864726 |
| 12 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 3.07460132 |
| 13 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.96285021 |
| 14 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.92345164 |
| 15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.80881099 |
| 16 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.58070088 |
| 17 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.56445920 |
| 18 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.54337304 |
| 19 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.48690293 |
| 20 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.41908111 |
| 21 | * CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.41803769 |
| 22 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.33242396 |
| 23 | * YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.32800069 |
| 24 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.31563569 |
| 25 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.06943212 |
| 26 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.05794800 |
| 27 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.03616922 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.98117827 |
| 29 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.83371667 |
| 30 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.81754737 |
| 31 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.81725608 |
| 32 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.78725815 |
| 33 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.76067634 |
| 34 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.72322461 |
| 35 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.65153456 |
| 36 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.60216426 |
| 37 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.57982870 |
| 38 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.53107356 |
| 39 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.51046349 |
| 40 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.47602068 |
| 41 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.47395882 |
| 42 | VDR_22108803_ChIP-Seq_LS180_Human | 1.47185850 |
| 43 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.45964027 |
| 44 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.44992168 |
| 45 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.37018354 |
| 46 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.34417187 |
| 47 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.32255159 |
| 48 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.31359356 |
| 49 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.30394086 |
| 50 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.29622553 |
| 51 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.29186403 |
| 52 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.28400483 |
| 53 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.25191029 |
| 54 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.24257002 |
| 55 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.23464322 |
| 56 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.23036030 |
| 57 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.22934306 |
| 58 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.20056165 |
| 59 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19314535 |
| 60 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.17693832 |
| 61 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.16264532 |
| 62 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.15858758 |
| 63 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.15455362 |
| 64 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.15405920 |
| 65 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.12700084 |
| 66 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.11579606 |
| 67 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.06624294 |
| 68 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.06387006 |
| 69 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.05899386 |
| 70 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.04753368 |
| 71 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.04207404 |
| 72 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.03894788 |
| 73 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.03456708 |
| 74 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.02253063 |
| 75 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.02025393 |
| 76 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.01879831 |
| 77 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.99488453 |
| 78 | * FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.98805378 |
| 79 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.97608532 |
| 80 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.97040188 |
| 81 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.96104220 |
| 82 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.94530744 |
| 83 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.94044424 |
| 84 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.93589374 |
| 85 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.93304781 |
| 86 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.92951314 |
| 87 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.91396132 |
| 88 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.91179282 |
| 89 | * YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.90415787 |
| 90 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.90331441 |
| 91 | * SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89933316 |
| 92 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.89494681 |
| 93 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.88597743 |
| 94 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.88368073 |
| 95 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.88069452 |
| 96 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.87872642 |
| 97 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.87750942 |
| 98 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.86825481 |
| 99 | EWS_26573619_Chip-Seq_HEK293_Human | 0.86639023 |
| 100 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.85602244 |
| 101 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.85439794 |
| 102 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.85136660 |
| 103 | NCOR_22424771_ChIP-Seq_293T_Human | 0.84448766 |
| 104 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.84285881 |
| 105 | FUS_26573619_Chip-Seq_HEK293_Human | 0.84191371 |
| 106 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.84163919 |
| 107 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.83172759 |
| 108 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.82958854 |
| 109 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.81664588 |
| 110 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.79354704 |
| 111 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.79261527 |
| 112 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.79090999 |
| 113 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.77906215 |
| 114 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.77842101 |
| 115 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.77826655 |
| 116 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.77503334 |
| 117 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.77503334 |
| 118 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.77348670 |
| 119 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.76988729 |
| 120 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.76842480 |
| 121 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.76682062 |
| 122 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.74636820 |
| 123 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.74539454 |
| 124 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.73645496 |
| 125 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.72864507 |
| 126 | * ERG_20517297_ChIP-Seq_VCAP_Human | 0.71345937 |
| 127 | * PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.70903862 |
| 128 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.70724514 |
| 129 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.70173514 |
| 130 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.69670955 |
| 131 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.68939391 |
| 132 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.68389321 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002837_dystrophic_cardiac_calcinosis | 6.20596428 |
| 2 | MP0003646_muscle_fatigue | 5.13401823 |
| 3 | MP0004084_abnormal_cardiac_muscle | 4.07757604 |
| 4 | MP0000751_myopathy | 3.88050587 |
| 5 | MP0004215_abnormal_myocardial_fiber | 3.82293213 |
| 6 | MP0000749_muscle_degeneration | 3.76608401 |
| 7 | MP0006036_abnormal_mitochondrial_physio | 3.62202254 |
| 8 | MP0004036_abnormal_muscle_relaxation | 3.54981556 |
| 9 | MP0005330_cardiomyopathy | 3.05543000 |
| 10 | MP0003787_abnormal_imprinting | 2.55406959 |
| 11 | MP0002972_abnormal_cardiac_muscle | 2.51728554 |
| 12 | MP0003806_abnormal_nucleotide_metabolis | 2.48822661 |
| 13 | MP0006035_abnormal_mitochondrial_morpho | 2.48021712 |
| 14 | MP0004043_abnormal_pH_regulation | 2.28010016 |
| 15 | MP0003137_abnormal_impulse_conducting | 2.22744115 |
| 16 | MP0005620_abnormal_muscle_contractility | 2.19325797 |
| 17 | MP0001529_abnormal_vocalization | 2.18093387 |
| 18 | MP0006072_abnormal_retinal_apoptosis | 2.17628777 |
| 19 | MP0006292_abnormal_olfactory_placode | 2.15924589 |
| 20 | MP0008775_abnormal_heart_ventricle | 2.14609894 |
| 21 | MP0003011_delayed_dark_adaptation | 2.08970686 |
| 22 | MP0000750_abnormal_muscle_regeneration | 2.08590096 |
| 23 | MP0004145_abnormal_muscle_electrophysio | 2.06371603 |
| 24 | MP0008877_abnormal_DNA_methylation | 2.05994674 |
| 25 | MP0005645_abnormal_hypothalamus_physiol | 2.03303579 |
| 26 | MP0004087_abnormal_muscle_fiber | 1.98590806 |
| 27 | MP0002106_abnormal_muscle_physiology | 1.94804522 |
| 28 | MP0004484_altered_response_of | 1.94635376 |
| 29 | MP0002163_abnormal_gland_morphology | 1.91963629 |
| 30 | MP0001544_abnormal_cardiovascular_syste | 1.88817907 |
| 31 | MP0005385_cardiovascular_system_phenoty | 1.88817907 |
| 32 | MP0002102_abnormal_ear_morphology | 1.88184138 |
| 33 | MP0002332_abnormal_exercise_endurance | 1.86986528 |
| 34 | MP0002269_muscular_atrophy | 1.81074509 |
| 35 | MP0003195_calcinosis | 1.79873913 |
| 36 | MP0003221_abnormal_cardiomyocyte_apopto | 1.77240052 |
| 37 | MP0008789_abnormal_olfactory_epithelium | 1.77219649 |
| 38 | MP0003186_abnormal_redox_activity | 1.76423075 |
| 39 | MP0005423_abnormal_somatic_nervous | 1.71883586 |
| 40 | MP0004085_abnormal_heartbeat | 1.70132359 |
| 41 | MP0004147_increased_porphyrin_level | 1.65242937 |
| 42 | MP0006138_congestive_heart_failure | 1.61399899 |
| 43 | MP0005499_abnormal_olfactory_system | 1.59003051 |
| 44 | MP0005394_taste/olfaction_phenotype | 1.59003051 |
| 45 | MP0004130_abnormal_muscle_cell | 1.57728261 |
| 46 | MP0008058_abnormal_DNA_repair | 1.56573154 |
| 47 | MP0005369_muscle_phenotype | 1.56407750 |
| 48 | MP0005551_abnormal_eye_electrophysiolog | 1.55474562 |
| 49 | MP0000747_muscle_weakness | 1.53798789 |
| 50 | MP0001188_hyperpigmentation | 1.52786250 |
| 51 | MP0005646_abnormal_pituitary_gland | 1.51035548 |
| 52 | MP0005379_endocrine/exocrine_gland_phen | 1.50187355 |
| 53 | MP0003123_paternal_imprinting | 1.46746922 |
| 54 | MP0000759_abnormal_skeletal_muscle | 1.45843467 |
| 55 | MP0008995_early_reproductive_senescence | 1.44871271 |
| 56 | MP0003880_abnormal_central_pattern | 1.44588276 |
| 57 | MP0006276_abnormal_autonomic_nervous | 1.42298724 |
| 58 | MP0003121_genomic_imprinting | 1.41905453 |
| 59 | MP0009379_abnormal_foot_pigmentation | 1.39819591 |
| 60 | MP0001905_abnormal_dopamine_level | 1.39128014 |
| 61 | MP0005266_abnormal_metabolism | 1.38507913 |
| 62 | MP0005253_abnormal_eye_physiology | 1.37143038 |
| 63 | MP0002938_white_spotting | 1.36041711 |
| 64 | MP0003786_premature_aging | 1.33446831 |
| 65 | MP0005670_abnormal_white_adipose | 1.32976348 |
| 66 | MP0005332_abnormal_amino_acid | 1.32955899 |
| 67 | MP0004270_analgesia | 1.30197892 |
| 68 | MP0010630_abnormal_cardiac_muscle | 1.27828072 |
| 69 | MP0001485_abnormal_pinna_reflex | 1.26270133 |
| 70 | MP0000013_abnormal_adipose_tissue | 1.26160349 |
| 71 | MP0003635_abnormal_synaptic_transmissio | 1.25756998 |
| 72 | MP0002557_abnormal_social/conspecific_i | 1.25502568 |
| 73 | MP0002572_abnormal_emotion/affect_behav | 1.25359910 |
| 74 | MP0005535_abnormal_body_temperature | 1.25353614 |
| 75 | MP0002653_abnormal_ependyma_morphology | 1.23699774 |
| 76 | MP0004859_abnormal_synaptic_plasticity | 1.22124279 |
| 77 | MP0001486_abnormal_startle_reflex | 1.21493526 |
| 78 | MP0004142_abnormal_muscle_tone | 1.20417934 |
| 79 | MP0003718_maternal_effect | 1.19855913 |
| 80 | MP0002736_abnormal_nociception_after | 1.19567704 |
| 81 | MP0000230_abnormal_systemic_arterial | 1.16663144 |
| 82 | MP0002127_abnormal_cardiovascular_syste | 1.15072072 |
| 83 | MP0003136_yellow_coat_color | 1.14538724 |
| 84 | MP0002876_abnormal_thyroid_physiology | 1.13828501 |
| 85 | MP0004133_heterotaxia | 1.12246890 |
| 86 | MP0000631_abnormal_neuroendocrine_gland | 1.12240424 |
| 87 | MP0008872_abnormal_physiological_respon | 1.11977861 |
| 88 | MP0002733_abnormal_thermal_nociception | 1.11896525 |
| 89 | MP0004233_abnormal_muscle_weight | 1.09942574 |
| 90 | MP0001986_abnormal_taste_sensitivity | 1.09237493 |
| 91 | MP0002160_abnormal_reproductive_system | 1.09081323 |
| 92 | MP0002063_abnormal_learning/memory/cond | 1.08623396 |
| 93 | MP0001764_abnormal_homeostasis | 1.05158261 |
| 94 | MP0005075_abnormal_melanosome_morpholog | 1.04863663 |
| 95 | MP0004742_abnormal_vestibular_system | 1.04199708 |
| 96 | MP0002735_abnormal_chemical_nociception | 1.02252924 |
| 97 | MP0002822_catalepsy | 1.01714710 |
| 98 | MP0001727_abnormal_embryo_implantation | 1.01425491 |
| 99 | MP0005636_abnormal_mineral_homeostasis | 1.00904996 |
| 100 | MP0000778_abnormal_nervous_system | 1.00658869 |
| 101 | MP0002277_abnormal_respiratory_mucosa | 1.00393847 |
| 102 | MP0002184_abnormal_innervation | 0.98625995 |
| 103 | MP0002638_abnormal_pupillary_reflex | 0.98596640 |
| 104 | MP0005083_abnormal_biliary_tract | 0.96004749 |
| 105 | MP0005451_abnormal_body_composition | 0.95425473 |
| 106 | MP0002272_abnormal_nervous_system | 0.94733955 |
| 107 | MP0002234_abnormal_pharynx_morphology | 0.94694827 |
| 108 | MP0005165_increased_susceptibility_to | 0.94513705 |
| 109 | MP0005389_reproductive_system_phenotype | 0.94226996 |
| 110 | MP0002752_abnormal_somatic_nervous | 0.94143210 |
| 111 | MP0002090_abnormal_vision | 0.94108982 |
| 112 | MP0002095_abnormal_skin_pigmentation | 0.92199512 |
| 113 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.91907935 |
| 114 | MP0000343_altered_response_to | 0.90995047 |
| 115 | MP0003828_pulmonary_edema | 0.90786863 |
| 116 | MP0009046_muscle_twitch | 0.90580519 |
| 117 | MP0004924_abnormal_behavior | 0.90324531 |
| 118 | MP0005386_behavior/neurological_phenoty | 0.90324531 |
| 119 | MP0004885_abnormal_endolymph | 0.90020578 |
| 120 | MP0003122_maternal_imprinting | 0.86674414 |
| 121 | MP0002229_neurodegeneration | 0.86485259 |
| 122 | MP0001756_abnormal_urination | 0.85836061 |
| 123 | MP0001968_abnormal_touch/_nociception | 0.85427157 |
| 124 | MP0002882_abnormal_neuron_morphology | 0.83448937 |
| 125 | MP0005376_homeostasis/metabolism_phenot | 0.82841793 |
| 126 | MP0009697_abnormal_copulation | 0.82326876 |
| 127 | MP0004811_abnormal_neuron_physiology | 0.82105970 |
| 128 | MP0002751_abnormal_autonomic_nervous | 0.80572011 |
| 129 | MP0001919_abnormal_reproductive_system | 0.79306959 |
| 130 | MP0005319_abnormal_enzyme/_coenzyme | 0.78852681 |
| 131 | MP0009643_abnormal_urine_homeostasis | 0.78684750 |
| 132 | MP0000955_abnormal_spinal_cord | 0.78449551 |
| 133 | MP0001293_anophthalmia | 0.77950790 |
| 134 | MP0002909_abnormal_adrenal_gland | 0.76590570 |
| 135 | MP0005084_abnormal_gallbladder_morpholo | 0.75613997 |
| 136 | MP0003950_abnormal_plasma_membrane | 0.74821268 |
| 137 | MP0005666_abnormal_adipose_tissue | 0.74474069 |
| 138 | MP0001440_abnormal_grooming_behavior | 0.72207852 |
| 139 | MP0005085_abnormal_gallbladder_physiolo | 0.71864515 |
| 140 | MP0010386_abnormal_urinary_bladder | 0.71709412 |
| 141 | MP0002078_abnormal_glucose_homeostasis | 0.71567944 |
| 142 | MP0000358_abnormal_cell_content/ | 0.69790182 |
| 143 | MP0003656_abnormal_erythrocyte_physiolo | 0.69563223 |
| 144 | MP0000372_irregular_coat_pigmentation | 0.69069900 |
| 145 | MP0002064_seizures | 0.69052550 |
| 146 | MP0002139_abnormal_hepatobiliary_system | 0.67267595 |
| 147 | MP0002734_abnormal_mechanical_nocicepti | 0.67190666 |
| 148 | MP0005360_urolithiasis | 0.66640718 |
| 149 | MP0004510_myositis | 0.65253687 |
| 150 | MP0009745_abnormal_behavioral_response | 0.64618897 |
| 151 | MP0008875_abnormal_xenobiotic_pharmacok | 0.63494819 |
| 152 | MP0001765_abnormal_ion_homeostasis | 0.62549693 |
| 153 | MP0001984_abnormal_olfaction | 0.60278271 |
| 154 | MP0003567_abnormal_fetal_cardiomyocyte | 0.59322997 |
| 155 | MP0002067_abnormal_sensory_capabilities | 0.58712501 |
| 156 | MP0008004_abnormal_stomach_pH | 0.50957846 |
| 157 | MP0002971_abnormal_brown_adipose | 0.50255421 |
| 158 | MP0001970_abnormal_pain_threshold | 0.49451072 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 7.20548394 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 6.86461531 |
| 3 | Mitochondrial inheritance (HP:0001427) | 6.22747673 |
| 4 | Acute encephalopathy (HP:0006846) | 6.20054045 |
| 5 | Progressive macrocephaly (HP:0004481) | 5.97374990 |
| 6 | Hepatocellular necrosis (HP:0001404) | 5.82553210 |
| 7 | Hepatic necrosis (HP:0002605) | 5.77817860 |
| 8 | Increased CSF lactate (HP:0002490) | 5.63820347 |
| 9 | Cerebral edema (HP:0002181) | 4.77846186 |
| 10 | Lactic acidosis (HP:0003128) | 4.28318301 |
| 11 | Increased serum pyruvate (HP:0003542) | 4.25970957 |
| 12 | Abnormality of glycolysis (HP:0004366) | 4.25970957 |
| 13 | Exercise intolerance (HP:0003546) | 4.18188952 |
| 14 | Sudden death (HP:0001699) | 4.17567663 |
| 15 | Respiratory failure (HP:0002878) | 4.14560369 |
| 16 | Lipid accumulation in hepatocytes (HP:0006561) | 4.08409988 |
| 17 | Increased hepatocellular lipid droplets (HP:0006565) | 4.07464398 |
| 18 | Increased intramyocellular lipid droplets (HP:0012240) | 4.00739180 |
| 19 | Increased muscle lipid content (HP:0009058) | 3.95229235 |
| 20 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.87735517 |
| 21 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.87735517 |
| 22 | Calf muscle hypertrophy (HP:0008981) | 3.75153981 |
| 23 | Increased serum lactate (HP:0002151) | 3.70059282 |
| 24 | Exercise-induced muscle cramps (HP:0003710) | 3.63712302 |
| 25 | Palpitations (HP:0001962) | 3.59396677 |
| 26 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.58732577 |
| 27 | Myoglobinuria (HP:0002913) | 3.54590853 |
| 28 | Pheochromocytoma (HP:0002666) | 3.54360368 |
| 29 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.51373354 |
| 30 | Neuroendocrine neoplasm (HP:0100634) | 3.47884868 |
| 31 | Optic disc pallor (HP:0000543) | 3.42185650 |
| 32 | Exercise-induced myalgia (HP:0003738) | 3.38317331 |
| 33 | Renal Fanconi syndrome (HP:0001994) | 3.27714923 |
| 34 | Leukodystrophy (HP:0002415) | 3.26748614 |
| 35 | Myokymia (HP:0002411) | 3.22124609 |
| 36 | Ventricular tachycardia (HP:0004756) | 3.21951010 |
| 37 | Rhabdomyolysis (HP:0003201) | 3.10784513 |
| 38 | Abnormal number of erythroid precursors (HP:0012131) | 3.07581562 |
| 39 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.02641497 |
| 40 | Conjunctival hamartoma (HP:0100780) | 2.98128134 |
| 41 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.93557902 |
| 42 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.91012634 |
| 43 | Dicarboxylic aciduria (HP:0003215) | 2.91012634 |
| 44 | Lipoatrophy (HP:0100578) | 2.88828369 |
| 45 | Lethargy (HP:0001254) | 2.88092047 |
| 46 | Generalized aminoaciduria (HP:0002909) | 2.84530215 |
| 47 | CNS demyelination (HP:0007305) | 2.83777094 |
| 48 | Atrial fibrillation (HP:0005110) | 2.83107569 |
| 49 | 3-Methylglutaconic aciduria (HP:0003535) | 2.79069740 |
| 50 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.77474520 |
| 51 | Abnormality of alanine metabolism (HP:0010916) | 2.77474520 |
| 52 | Hyperalaninemia (HP:0003348) | 2.77474520 |
| 53 | Ketoacidosis (HP:0001993) | 2.75367765 |
| 54 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.73979890 |
| 55 | Glycosuria (HP:0003076) | 2.71429134 |
| 56 | Abnormality of urine glucose concentration (HP:0011016) | 2.71429134 |
| 57 | Muscle fiber splitting (HP:0003555) | 2.71379855 |
| 58 | Abnormality of the calf musculature (HP:0001430) | 2.70673007 |
| 59 | Respiratory difficulties (HP:0002880) | 2.65909796 |
| 60 | Supraventricular tachycardia (HP:0004755) | 2.65906545 |
| 61 | Primary atrial arrhythmia (HP:0001692) | 2.62842378 |
| 62 | Reticulocytopenia (HP:0001896) | 2.61281593 |
| 63 | Supraventricular arrhythmia (HP:0005115) | 2.56366608 |
| 64 | Ragged-red muscle fibers (HP:0003200) | 2.53761287 |
| 65 | Exertional dyspnea (HP:0002875) | 2.53535923 |
| 66 | Dilated cardiomyopathy (HP:0001644) | 2.53265476 |
| 67 | Emotional lability (HP:0000712) | 2.50181697 |
| 68 | Hypoglycemic coma (HP:0001325) | 2.46309871 |
| 69 | Molar tooth sign on MRI (HP:0002419) | 2.42599828 |
| 70 | Abnormality of midbrain morphology (HP:0002418) | 2.42599828 |
| 71 | Pancreatic fibrosis (HP:0100732) | 2.41780516 |
| 72 | Neoplasm of the adrenal gland (HP:0100631) | 2.41734848 |
| 73 | Macrocytic anemia (HP:0001972) | 2.41328319 |
| 74 | Aplastic anemia (HP:0001915) | 2.40581611 |
| 75 | Medial flaring of the eyebrow (HP:0010747) | 2.40563985 |
| 76 | Syncope (HP:0001279) | 2.38252009 |
| 77 | Vomiting (HP:0002013) | 2.35939942 |
| 78 | Myotonia (HP:0002486) | 2.34498955 |
| 79 | Pancreatic cysts (HP:0001737) | 2.32222443 |
| 80 | Esophageal neoplasm (HP:0100751) | 2.31901396 |
| 81 | Neoplasm of head and neck (HP:0012288) | 2.31901396 |
| 82 | Proximal tubulopathy (HP:0000114) | 2.30711328 |
| 83 | Nausea (HP:0002018) | 2.30045413 |
| 84 | Prolonged QT interval (HP:0001657) | 2.30028665 |
| 85 | X-linked dominant inheritance (HP:0001423) | 2.27909290 |
| 86 | Abnormality of renal resorption (HP:0011038) | 2.27626812 |
| 87 | Type I transferrin isoform profile (HP:0003642) | 2.23392511 |
| 88 | Methylmalonic aciduria (HP:0012120) | 2.20358102 |
| 89 | Cerebral hypomyelination (HP:0006808) | 2.20179045 |
| 90 | Abnormality of the anterior horn cell (HP:0006802) | 2.18355418 |
| 91 | Degeneration of anterior horn cells (HP:0002398) | 2.18355418 |
| 92 | Muscle stiffness (HP:0003552) | 2.15299436 |
| 93 | Ketosis (HP:0001946) | 2.14189489 |
| 94 | Hyperphosphaturia (HP:0003109) | 2.12127984 |
| 95 | Methylmalonic acidemia (HP:0002912) | 2.11499079 |
| 96 | EMG: myopathic abnormalities (HP:0003458) | 2.11249112 |
| 97 | Gliosis (HP:0002171) | 2.10597183 |
| 98 | Poor suck (HP:0002033) | 2.10029336 |
| 99 | Microvesicular hepatic steatosis (HP:0001414) | 2.09995776 |
| 100 | True hermaphroditism (HP:0010459) | 2.05688801 |
| 101 | Metabolic acidosis (HP:0001942) | 2.05642569 |
| 102 | Abnormality of the labia minora (HP:0012880) | 2.02912021 |
| 103 | Nephronophthisis (HP:0000090) | 2.02691272 |
| 104 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.02061424 |
| 105 | Subaortic stenosis (HP:0001682) | 2.02061424 |
| 106 | Hyperglycinemia (HP:0002154) | 1.99002607 |
| 107 | Left ventricular hypertrophy (HP:0001712) | 1.98250843 |
| 108 | Gait imbalance (HP:0002141) | 1.95645358 |
| 109 | Hyperglycinuria (HP:0003108) | 1.89789787 |
| 110 | Congenital primary aphakia (HP:0007707) | 1.89452882 |
| 111 | Limb dystonia (HP:0002451) | 1.89431921 |
| 112 | Ventricular arrhythmia (HP:0004308) | 1.89149656 |
| 113 | Asymmetric septal hypertrophy (HP:0001670) | 1.88817693 |
| 114 | Ventricular fibrillation (HP:0001663) | 1.85523365 |
| 115 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.83173417 |
| 116 | Hyperammonemia (HP:0001987) | 1.81759558 |
| 117 | Hypothermia (HP:0002045) | 1.81588712 |
| 118 | Tinnitus (HP:0000360) | 1.81498987 |
| 119 | Abnormal protein glycosylation (HP:0012346) | 1.80859634 |
| 120 | Abnormal glycosylation (HP:0012345) | 1.80859634 |
| 121 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.80859634 |
| 122 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.80859634 |
| 123 | Nephrogenic diabetes insipidus (HP:0009806) | 1.79158231 |
| 124 | Type 2 muscle fiber atrophy (HP:0003554) | 1.79112848 |
| 125 | Colon cancer (HP:0003003) | 1.78094187 |
| 126 | Pancytopenia (HP:0001876) | 1.77638243 |
| 127 | Cerebral hemorrhage (HP:0001342) | 1.77413209 |
| 128 | Progressive microcephaly (HP:0000253) | 1.77130439 |
| 129 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.76262227 |
| 130 | Abnormality of the vocal cords (HP:0008777) | 1.75812129 |
| 131 | Sclerocornea (HP:0000647) | 1.75652614 |
| 132 | Blindness (HP:0000618) | 1.75146308 |
| 133 | Abnormal urine phosphate concentration (HP:0012599) | 1.73918373 |
| 134 | Gout (HP:0001997) | 1.72745427 |
| 135 | Abnormal EKG (HP:0003115) | 1.72241246 |
| 136 | Testicular atrophy (HP:0000029) | 1.71658895 |
| 137 | Hyporeflexia of lower limbs (HP:0002600) | 1.70496880 |
| 138 | Right ventricular cardiomyopathy (HP:0011663) | 1.69932286 |
| 139 | CNS hypomyelination (HP:0003429) | 1.67444504 |
| 140 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.66360264 |
| 141 | Congenital stationary night blindness (HP:0007642) | 1.62462282 |
| 142 | Congenital, generalized hypertrichosis (HP:0004540) | 1.62042830 |
| 143 | Oral leukoplakia (HP:0002745) | 1.61573406 |
| 144 | Muscle fiber atrophy (HP:0100295) | 1.60257070 |
| 145 | Delayed CNS myelination (HP:0002188) | 1.57008359 |
| 146 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.55130359 |
| 147 | Renal cortical cysts (HP:0000803) | 1.54804685 |
| 148 | Polyphagia (HP:0002591) | 1.53464152 |
| 149 | Retinal dysplasia (HP:0007973) | 1.52553172 |
| 150 | Muscular hypotonia of the trunk (HP:0008936) | 1.51791003 |
| 151 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.51644484 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | OBSCN | 4.23048158 |
| 2 | MYLK | 4.09979920 |
| 3 | VRK2 | 4.09213676 |
| 4 | BCKDK | 3.83219430 |
| 5 | PDK3 | 3.30670982 |
| 6 | PDK4 | 3.30670982 |
| 7 | NME1 | 3.27028652 |
| 8 | MAP3K12 | 2.49297938 |
| 9 | STK16 | 2.47762305 |
| 10 | NEK1 | 2.43090108 |
| 11 | NME2 | 2.41764322 |
| 12 | MUSK | 2.26733178 |
| 13 | MAP4K2 | 2.25640767 |
| 14 | PDK2 | 2.17346407 |
| 15 | WNK4 | 2.16497435 |
| 16 | PHKG2 | 2.13821784 |
| 17 | PHKG1 | 2.13821784 |
| 18 | TTN | 2.11826862 |
| 19 | TESK2 | 2.09885029 |
| 20 | LMTK2 | 2.02622831 |
| 21 | PINK1 | 1.89483325 |
| 22 | ARAF | 1.82223244 |
| 23 | TRIM28 | 1.80227573 |
| 24 | GRK7 | 1.76703610 |
| 25 | EIF2AK1 | 1.73897032 |
| 26 | BUB1 | 1.71942550 |
| 27 | NUAK1 | 1.59322350 |
| 28 | PIK3CA | 1.52605224 |
| 29 | STK24 | 1.52495144 |
| 30 | WNK3 | 1.52247055 |
| 31 | ZAK | 1.49282566 |
| 32 | CSNK1G3 | 1.46032711 |
| 33 | CSNK1G2 | 1.43079994 |
| 34 | LIMK1 | 1.40699899 |
| 35 | OXSR1 | 1.33002422 |
| 36 | ILK | 1.31994352 |
| 37 | BRAF | 1.27299210 |
| 38 | CDC7 | 1.22438738 |
| 39 | GRK1 | 1.20284702 |
| 40 | MARK1 | 1.19231188 |
| 41 | DAPK2 | 1.16586756 |
| 42 | EIF2AK3 | 1.16264140 |
| 43 | STK39 | 1.14960596 |
| 44 | CAMK2D | 1.14077254 |
| 45 | STK38L | 1.13225705 |
| 46 | CSNK1G1 | 1.12269841 |
| 47 | EPHA4 | 1.12020487 |
| 48 | PLK3 | 1.11218173 |
| 49 | DAPK3 | 1.10643741 |
| 50 | VRK1 | 1.06408559 |
| 51 | FRK | 1.06142343 |
| 52 | TXK | 1.04848293 |
| 53 | TIE1 | 1.03243433 |
| 54 | ABL2 | 1.02115094 |
| 55 | CSNK1A1L | 0.99631689 |
| 56 | MAP3K11 | 0.99163893 |
| 57 | CCNB1 | 0.93101635 |
| 58 | CASK | 0.92769988 |
| 59 | KDR | 0.91871648 |
| 60 | MAP2K7 | 0.91136074 |
| 61 | PBK | 0.90471672 |
| 62 | TESK1 | 0.87989759 |
| 63 | MAPK13 | 0.85714784 |
| 64 | GRK5 | 0.83618869 |
| 65 | TNIK | 0.82177590 |
| 66 | CAMK2G | 0.82030869 |
| 67 | MST4 | 0.80385642 |
| 68 | RPS6KA5 | 0.78967545 |
| 69 | CAMK2A | 0.75688482 |
| 70 | PLK1 | 0.74077082 |
| 71 | PLK2 | 0.73139003 |
| 72 | CDK19 | 0.71569191 |
| 73 | PIM2 | 0.68632378 |
| 74 | BCR | 0.68494166 |
| 75 | CAMK2B | 0.65859741 |
| 76 | MAP2K4 | 0.62635102 |
| 77 | MAPK12 | 0.62561311 |
| 78 | PRKACA | 0.59774683 |
| 79 | MINK1 | 0.59435473 |
| 80 | DAPK1 | 0.59388211 |
| 81 | PLK4 | 0.58782923 |
| 82 | WEE1 | 0.58616456 |
| 83 | MAPKAPK3 | 0.56695228 |
| 84 | MAP3K4 | 0.55323555 |
| 85 | BMPR2 | 0.53744025 |
| 86 | PRKCE | 0.53437463 |
| 87 | CSNK1A1 | 0.52681935 |
| 88 | PASK | 0.51822090 |
| 89 | TAOK3 | 0.51659746 |
| 90 | TSSK6 | 0.51146473 |
| 91 | SRPK1 | 0.51135702 |
| 92 | DYRK2 | 0.50963504 |
| 93 | DYRK3 | 0.50953480 |
| 94 | ADRBK1 | 0.49679460 |
| 95 | BMPR1B | 0.49114867 |
| 96 | PIK3CG | 0.47146129 |
| 97 | PRKCQ | 0.46735279 |
| 98 | ATR | 0.46230721 |
| 99 | LRRK2 | 0.46014565 |
| 100 | PRKCG | 0.45329259 |
| 101 | CDK8 | 0.44632847 |
| 102 | PAK3 | 0.44510040 |
| 103 | TAF1 | 0.44486890 |
| 104 | ADRBK2 | 0.43972825 |
| 105 | NTRK3 | 0.43892546 |
| 106 | INSRR | 0.43862450 |
| 107 | ROCK1 | 0.43317157 |
| 108 | ROCK2 | 0.41847525 |
| 109 | CSNK1E | 0.41737548 |
| 110 | NTRK2 | 0.41673747 |
| 111 | CDK14 | 0.41667634 |
| 112 | PTK2B | 0.41242332 |
| 113 | AURKA | 0.40305342 |
| 114 | TLK1 | 0.40157063 |
| 115 | CSNK2A1 | 0.38075277 |
| 116 | AKT3 | 0.36239170 |
| 117 | PRKACB | 0.35805028 |
| 118 | MAP3K5 | 0.34855613 |
| 119 | UHMK1 | 0.34619653 |
| 120 | BRSK2 | 0.33316672 |
| 121 | FLT3 | 0.33194472 |
| 122 | BRSK1 | 0.32381816 |
| 123 | MAP2K6 | 0.32178186 |
| 124 | RPS6KL1 | 0.32105020 |
| 125 | RPS6KC1 | 0.32105020 |
| 126 | PKN1 | 0.32054585 |
| 127 | CAMKK2 | 0.31883178 |
| 128 | CDC42BPA | 0.31038174 |
| 129 | PRKACG | 0.29586807 |
| 130 | CSNK2A2 | 0.29107967 |
| 131 | CAMK1 | 0.28979689 |
| 132 | PKN2 | 0.25831751 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.89112793 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 5.23252169 |
| 3 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 4.87289178 |
| 4 | Alzheimers disease_Homo sapiens_hsa05010 | 3.76905332 |
| 5 | Huntingtons disease_Homo sapiens_hsa05016 | 3.60012315 |
| 6 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 3.42938138 |
| 7 | * Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 3.28113201 |
| 8 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.08730758 |
| 9 | Proteasome_Homo sapiens_hsa03050 | 3.00591097 |
| 10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.55145828 |
| 11 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.21457296 |
| 12 | Ribosome_Homo sapiens_hsa03010 | 2.16999822 |
| 13 | Carbon metabolism_Homo sapiens_hsa01200 | 2.10856450 |
| 14 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.86845830 |
| 15 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.81394790 |
| 16 | Protein export_Homo sapiens_hsa03060 | 1.72251606 |
| 17 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.67116182 |
| 18 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.63324022 |
| 19 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.62677191 |
| 20 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.62610807 |
| 21 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.61143109 |
| 22 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.40598230 |
| 23 | RNA polymerase_Homo sapiens_hsa03020 | 1.38939303 |
| 24 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.34799276 |
| 25 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.34083091 |
| 26 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.27676127 |
| 27 | Phototransduction_Homo sapiens_hsa04744 | 1.16721255 |
| 28 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.16599642 |
| 29 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.11412503 |
| 30 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.00847293 |
| 31 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.97082302 |
| 32 | Peroxisome_Homo sapiens_hsa04146 | 0.96484617 |
| 33 | Nicotine addiction_Homo sapiens_hsa05033 | 0.95448856 |
| 34 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.94339129 |
| 35 | Basal transcription factors_Homo sapiens_hsa03022 | 0.93367719 |
| 36 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.92002653 |
| 37 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.90308137 |
| 38 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.89695020 |
| 39 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.89673912 |
| 40 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.87502644 |
| 41 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.85899563 |
| 42 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.83831248 |
| 43 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.82002036 |
| 44 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.77483496 |
| 45 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.76530542 |
| 46 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.73273291 |
| 47 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.71767264 |
| 48 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.71579863 |
| 49 | RNA transport_Homo sapiens_hsa03013 | 0.70364968 |
| 50 | Galactose metabolism_Homo sapiens_hsa00052 | 0.66380736 |
| 51 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.62520381 |
| 52 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.61916453 |
| 53 | Purine metabolism_Homo sapiens_hsa00230 | 0.61739487 |
| 54 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.58313546 |
| 55 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.57419749 |
| 56 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.52842959 |
| 57 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.51127242 |
| 58 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.49840921 |
| 59 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.49434376 |
| 60 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.49227554 |
| 61 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.48192285 |
| 62 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.47890734 |
| 63 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.47652487 |
| 64 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.45845107 |
| 65 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.45565279 |
| 66 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.44994121 |
| 67 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.44178079 |
| 68 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.42611170 |
| 69 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.42525919 |
| 70 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.41648397 |
| 71 | Sulfur relay system_Homo sapiens_hsa04122 | 0.40905796 |
| 72 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.39266590 |
| 73 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.38784005 |
| 74 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.37732364 |
| 75 | Morphine addiction_Homo sapiens_hsa05032 | 0.36389663 |
| 76 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.36049489 |
| 77 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.34180022 |
| 78 | DNA replication_Homo sapiens_hsa03030 | 0.33513539 |
| 79 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.31908410 |
| 80 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.30277927 |
| 81 | Mismatch repair_Homo sapiens_hsa03430 | 0.30198523 |
| 82 | Olfactory transduction_Homo sapiens_hsa04740 | 0.29753182 |
| 83 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.28876992 |
| 84 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.28874944 |
| 85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27688901 |
| 86 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26153457 |
| 87 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.25379579 |
| 88 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.24722603 |
| 89 | Retinol metabolism_Homo sapiens_hsa00830 | 0.24526419 |
| 90 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.24203789 |
| 91 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.23584275 |
| 92 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.21628976 |
| 93 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.21404959 |
| 94 | Circadian entrainment_Homo sapiens_hsa04713 | 0.21328069 |
| 95 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.20706154 |
| 96 | Phagosome_Homo sapiens_hsa04145 | 0.20489475 |
| 97 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.19796649 |
| 98 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.19573425 |
| 99 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.19275185 |
| 100 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.19224316 |
| 101 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.19152918 |
| 102 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.18609385 |
| 103 | Alcoholism_Homo sapiens_hsa05034 | 0.18583510 |
| 104 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.18285343 |
| 105 | Histidine metabolism_Homo sapiens_hsa00340 | 0.17918895 |
| 106 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.15770205 |
| 107 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.15537485 |
| 108 | RNA degradation_Homo sapiens_hsa03018 | 0.14527099 |
| 109 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.13965726 |
| 110 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.13917727 |
| 111 | Spliceosome_Homo sapiens_hsa03040 | 0.13651764 |
| 112 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.12663202 |
| 113 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.12373783 |
| 114 | Taste transduction_Homo sapiens_hsa04742 | 0.11151488 |
| 115 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.11090106 |
| 116 | Homologous recombination_Homo sapiens_hsa03440 | 0.10278743 |
| 117 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.10166959 |
| 118 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.08207722 |
| 119 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.07762568 |
| 120 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.07317388 |
| 121 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.06499614 |
| 122 | GABAergic synapse_Homo sapiens_hsa04727 | 0.05694744 |
| 123 | Base excision repair_Homo sapiens_hsa03410 | 0.05352771 |
| 124 | Insulin secretion_Homo sapiens_hsa04911 | 0.05219169 |
| 125 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.04930570 |

