NDUFB8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.99113031
2ATP synthesis coupled proton transport (GO:0015986)9.26455714
3energy coupled proton transport, down electrochemical gradient (GO:0015985)9.26455714
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.37763098
5* respiratory electron transport chain (GO:0022904)8.07489262
6* electron transport chain (GO:0022900)7.86908191
7tricarboxylic acid cycle (GO:0006099)6.62791121
8oxidative phosphorylation (GO:0006119)6.56646844
9ATP biosynthetic process (GO:0006754)5.49876749
10NADH metabolic process (GO:0006734)5.45455021
11protein complex biogenesis (GO:0070271)5.35181244
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.29597514
13NADH dehydrogenase complex assembly (GO:0010257)5.29597514
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.29597514
15mitochondrial respiratory chain complex assembly (GO:0033108)4.96422613
16purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.92489998
17purine nucleoside triphosphate biosynthetic process (GO:0009145)4.88807012
18hydrogen ion transmembrane transport (GO:1902600)4.80747133
19sarcomere organization (GO:0045214)4.49346729
20heart contraction (GO:0060047)4.47667549
21heart process (GO:0003015)4.47667549
22inner mitochondrial membrane organization (GO:0007007)4.46217863
23ribonucleoside triphosphate biosynthetic process (GO:0009201)4.41313535
24aerobic respiration (GO:0009060)4.39388316
25succinate metabolic process (GO:0006105)4.39265682
26chaperone-mediated protein transport (GO:0072321)4.38037951
27regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.37104224
28regulation of acyl-CoA biosynthetic process (GO:0050812)4.30111125
29muscle filament sliding (GO:0030049)4.29836751
30actin-myosin filament sliding (GO:0033275)4.29836751
31regulation of mitochondrial translation (GO:0070129)4.21661435
32proton transport (GO:0015992)4.15531318
33ribosomal small subunit assembly (GO:0000028)4.14746891
34hydrogen transport (GO:0006818)4.09525874
35regulation of cofactor metabolic process (GO:0051193)4.06248882
36regulation of coenzyme metabolic process (GO:0051196)4.06248882
37regulation of oxidative phosphorylation (GO:0002082)4.00908280
38viral transcription (GO:0019083)3.94887396
39nucleoside triphosphate biosynthetic process (GO:0009142)3.94831946
40quinone biosynthetic process (GO:1901663)3.93936312
41ubiquinone biosynthetic process (GO:0006744)3.93936312
42oxaloacetate metabolic process (GO:0006107)3.92068192
43cardiac myofibril assembly (GO:0055003)3.90104514
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.84791693
45DNA deamination (GO:0045006)3.84131878
46cotranslational protein targeting to membrane (GO:0006613)3.81665673
47translational termination (GO:0006415)3.81269512
48termination of RNA polymerase III transcription (GO:0006386)3.81097080
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.81097080
50protein targeting to ER (GO:0045047)3.78238044
51purine nucleoside monophosphate biosynthetic process (GO:0009127)3.78017565
52purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.78017565
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.72669151
54cytochrome complex assembly (GO:0017004)3.69551362
55myofibril assembly (GO:0030239)3.65244025
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64813481
57respiratory chain complex IV assembly (GO:0008535)3.64182413
58sequestering of actin monomers (GO:0042989)3.63871909
59mitochondrial transport (GO:0006839)3.62757807
60protein localization to endoplasmic reticulum (GO:0070972)3.62444920
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.61658079
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.58969239
63positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.58884582
64cullin deneddylation (GO:0010388)3.58228762
65cellular respiration (GO:0045333)3.58119024
66negative regulation of ligase activity (GO:0051352)3.57615298
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57615298
68cardiac muscle contraction (GO:0060048)3.55517386
69protein neddylation (GO:0045116)3.55460964
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52242529
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52242529
72regulation of cellular respiration (GO:0043457)3.50573746
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50069753
74regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.48854509
75ubiquinone metabolic process (GO:0006743)3.48388530
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47039631
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47039631
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47039631
79intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45823898
80signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45823898
81ATP hydrolysis coupled proton transport (GO:0015991)3.44950699
82energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.44950699
83maturation of SSU-rRNA (GO:0030490)3.44597565
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44545193
85regulation of relaxation of muscle (GO:1901077)3.44312036
86actin-mediated cell contraction (GO:0070252)3.41956625
87translational elongation (GO:0006414)3.41274875
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40450393
89ribosomal small subunit biogenesis (GO:0042274)3.36311850
90protein deneddylation (GO:0000338)3.34564989
91* generation of precursor metabolites and energy (GO:0006091)3.34094033
92signal transduction involved in DNA integrity checkpoint (GO:0072401)3.30408799
93signal transduction involved in DNA damage checkpoint (GO:0072422)3.30408799
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30153825
95signal transduction involved in cell cycle checkpoint (GO:0072395)3.29684118
96intracellular protein transmembrane import (GO:0044743)3.29224638
97translation (GO:0006412)3.28035991
98regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.27818719
99protein targeting to mitochondrion (GO:0006626)3.25974093
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25296538
101establishment of protein localization to mitochondrion (GO:0072655)3.21166306
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20799017
103proteasome assembly (GO:0043248)3.20119105
104regulation of cellular amino acid metabolic process (GO:0006521)3.19505987
105cardiac muscle tissue morphogenesis (GO:0055008)3.19028312
106branched-chain amino acid catabolic process (GO:0009083)3.16604940
107behavioral response to nicotine (GO:0035095)3.13692909
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13532092
109pseudouridine synthesis (GO:0001522)3.13356976
110purine nucleoside biosynthetic process (GO:0042451)3.13239224
111purine ribonucleoside biosynthetic process (GO:0046129)3.13239224
112ribonucleoside monophosphate biosynthetic process (GO:0009156)3.12952805
113rRNA modification (GO:0000154)3.11571061
114negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.11106638
115L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08878687
116protein localization to mitochondrion (GO:0070585)3.08395775
117platelet dense granule organization (GO:0060155)3.08336559
118viral life cycle (GO:0019058)3.02355217
119regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.02203981
120aspartate family amino acid catabolic process (GO:0009068)3.00611996
121water-soluble vitamin biosynthetic process (GO:0042364)2.98924615
122negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.98754320
123deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.98367307
124aldehyde catabolic process (GO:0046185)2.97012153
125regulation of sulfur metabolic process (GO:0042762)2.96504282
126mannosylation (GO:0097502)2.96137324
127positive regulation of ligase activity (GO:0051351)2.95689336
128ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.95586645
129regulation of cellular amine metabolic process (GO:0033238)2.95556267
130cellular protein complex disassembly (GO:0043624)2.95543541
131sarcoplasmic reticulum calcium ion transport (GO:0070296)2.95243464
132metallo-sulfur cluster assembly (GO:0031163)2.94791678
133iron-sulfur cluster assembly (GO:0016226)2.94791678
134regulation of cell communication by electrical coupling (GO:0010649)2.94332176
135cellular component biogenesis (GO:0044085)2.94307216
136nucleoside monophosphate biosynthetic process (GO:0009124)2.91983495
137cardiac muscle cell development (GO:0055013)2.91906934
138GTP biosynthetic process (GO:0006183)2.91636369
139regulation of actin filament-based movement (GO:1903115)2.91367293
140translational initiation (GO:0006413)2.91135443
141protein-cofactor linkage (GO:0018065)2.90830367
142regulation of skeletal muscle contraction (GO:0014819)2.88178087
143negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86044442
144striated muscle contraction (GO:0006941)2.85294183
145regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.85150595
146lysine catabolic process (GO:0006554)2.84798337
147lysine metabolic process (GO:0006553)2.84798337
148muscle tissue morphogenesis (GO:0060415)2.84624395
149spliceosomal snRNP assembly (GO:0000387)2.82208047
150DNA damage response, detection of DNA damage (GO:0042769)2.81145778
151negative regulation of potassium ion transmembrane transport (GO:1901380)2.79272965
152regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.77360113
153base-excision repair, AP site formation (GO:0006285)2.76917383
1542-oxoglutarate metabolic process (GO:0006103)2.73592110
155ribonucleoside biosynthetic process (GO:0042455)2.73469329
156guanosine-containing compound biosynthetic process (GO:1901070)2.70235180
157antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69023360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.92307124
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.67995740
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.17582125
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.01453740
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.98773869
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74991855
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.72620276
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.71712895
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42770724
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.32207063
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.16864726
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.07460132
13* SRF_21415370_ChIP-Seq_HL-1_Mouse2.96285021
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92345164
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80881099
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58070088
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.56445920
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54337304
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48690293
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41908111
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41803769
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33242396
23* YY1_21170310_ChIP-Seq_MESCs_Mouse2.32800069
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31563569
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06943212
26* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.05794800
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03616922
28DCP1A_22483619_ChIP-Seq_HELA_Human1.98117827
29* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.83371667
30BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.81754737
31VDR_23849224_ChIP-Seq_CD4+_Human1.81725608
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78725815
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76067634
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.72322461
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65153456
36ZNF274_21170338_ChIP-Seq_K562_Hela1.60216426
37* GABP_19822575_ChIP-Seq_HepG2_Human1.57982870
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53107356
39XRN2_22483619_ChIP-Seq_HELA_Human1.51046349
40FOXP3_21729870_ChIP-Seq_TREG_Human1.47602068
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.47395882
42VDR_22108803_ChIP-Seq_LS180_Human1.47185850
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45964027
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44992168
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37018354
46CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.34417187
47* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32255159
48CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31359356
49ELK1_19687146_ChIP-ChIP_HELA_Human1.30394086
50TTF2_22483619_ChIP-Seq_HELA_Human1.29622553
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29186403
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.28400483
53TP53_22573176_ChIP-Seq_HFKS_Human1.25191029
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24257002
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23464322
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23036030
57* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22934306
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20056165
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19314535
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17693832
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16264532
62GATA4_21415370_ChIP-Seq_HL-1_Mouse1.15858758
63IGF1R_20145208_ChIP-Seq_DFB_Human1.15455362
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15405920
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12700084
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11579606
67EZH2_22144423_ChIP-Seq_EOC_Human1.06624294
68REST_21632747_ChIP-Seq_MESCs_Mouse1.06387006
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.05899386
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04753368
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04207404
72* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03894788
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.03456708
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02253063
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02025393
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01879831
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99488453
78* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98805378
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97608532
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97040188
81* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96104220
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94530744
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94044424
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93589374
85KDM5A_27292631_Chip-Seq_BREAST_Human0.93304781
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92951314
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91396132
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91179282
89* YY1_22570637_ChIP-Seq_MALME-3M_Human0.90415787
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90331441
91* SOX2_16153702_ChIP-ChIP_HESCs_Human0.89933316
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.89494681
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88597743
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88368073
95STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88069452
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87872642
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.87750942
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86825481
99EWS_26573619_Chip-Seq_HEK293_Human0.86639023
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85602244
101ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85439794
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85136660
103NCOR_22424771_ChIP-Seq_293T_Human0.84448766
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84285881
105FUS_26573619_Chip-Seq_HEK293_Human0.84191371
106IRF1_19129219_ChIP-ChIP_H3396_Human0.84163919
107FOXP1_21924763_ChIP-Seq_HESCs_Human0.83172759
108MYC_18940864_ChIP-ChIP_HL60_Human0.82958854
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81664588
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79354704
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79261527
112TET1_21451524_ChIP-Seq_MESCs_Mouse0.79090999
113RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77906215
114ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77842101
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.77826655
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77503334
117FOXA1_25329375_ChIP-Seq_VCAP_Human0.77503334
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.77348670
119CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76988729
120RNF2_27304074_Chip-Seq_NSC_Mouse0.76842480
121TAF2_19829295_ChIP-Seq_ESCs_Human0.76682062
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74636820
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74539454
124PADI4_21655091_ChIP-ChIP_MCF-7_Human0.73645496
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72864507
126* ERG_20517297_ChIP-Seq_VCAP_Human0.71345937
127* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70903862
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.70724514
129NANOG_20526341_ChIP-Seq_ESCs_Human0.70173514
130CIITA_25753668_ChIP-Seq_RAJI_Human0.69670955
131REST_19997604_ChIP-ChIP_NEURONS_Mouse0.68939391
132HTT_18923047_ChIP-ChIP_STHdh_Human0.68389321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.20596428
2MP0003646_muscle_fatigue5.13401823
3MP0004084_abnormal_cardiac_muscle4.07757604
4MP0000751_myopathy3.88050587
5MP0004215_abnormal_myocardial_fiber3.82293213
6MP0000749_muscle_degeneration3.76608401
7MP0006036_abnormal_mitochondrial_physio3.62202254
8MP0004036_abnormal_muscle_relaxation3.54981556
9MP0005330_cardiomyopathy3.05543000
10MP0003787_abnormal_imprinting2.55406959
11MP0002972_abnormal_cardiac_muscle2.51728554
12MP0003806_abnormal_nucleotide_metabolis2.48822661
13MP0006035_abnormal_mitochondrial_morpho2.48021712
14MP0004043_abnormal_pH_regulation2.28010016
15MP0003137_abnormal_impulse_conducting2.22744115
16MP0005620_abnormal_muscle_contractility2.19325797
17MP0001529_abnormal_vocalization2.18093387
18MP0006072_abnormal_retinal_apoptosis2.17628777
19MP0006292_abnormal_olfactory_placode2.15924589
20MP0008775_abnormal_heart_ventricle2.14609894
21MP0003011_delayed_dark_adaptation2.08970686
22MP0000750_abnormal_muscle_regeneration2.08590096
23MP0004145_abnormal_muscle_electrophysio2.06371603
24MP0008877_abnormal_DNA_methylation2.05994674
25MP0005645_abnormal_hypothalamus_physiol2.03303579
26MP0004087_abnormal_muscle_fiber1.98590806
27MP0002106_abnormal_muscle_physiology1.94804522
28MP0004484_altered_response_of1.94635376
29MP0002163_abnormal_gland_morphology1.91963629
30MP0001544_abnormal_cardiovascular_syste1.88817907
31MP0005385_cardiovascular_system_phenoty1.88817907
32MP0002102_abnormal_ear_morphology1.88184138
33MP0002332_abnormal_exercise_endurance1.86986528
34MP0002269_muscular_atrophy1.81074509
35MP0003195_calcinosis1.79873913
36MP0003221_abnormal_cardiomyocyte_apopto1.77240052
37MP0008789_abnormal_olfactory_epithelium1.77219649
38MP0003186_abnormal_redox_activity1.76423075
39MP0005423_abnormal_somatic_nervous1.71883586
40MP0004085_abnormal_heartbeat1.70132359
41MP0004147_increased_porphyrin_level1.65242937
42MP0006138_congestive_heart_failure1.61399899
43MP0005499_abnormal_olfactory_system1.59003051
44MP0005394_taste/olfaction_phenotype1.59003051
45MP0004130_abnormal_muscle_cell1.57728261
46MP0008058_abnormal_DNA_repair1.56573154
47MP0005369_muscle_phenotype1.56407750
48MP0005551_abnormal_eye_electrophysiolog1.55474562
49MP0000747_muscle_weakness1.53798789
50MP0001188_hyperpigmentation1.52786250
51MP0005646_abnormal_pituitary_gland1.51035548
52MP0005379_endocrine/exocrine_gland_phen1.50187355
53MP0003123_paternal_imprinting1.46746922
54MP0000759_abnormal_skeletal_muscle1.45843467
55MP0008995_early_reproductive_senescence1.44871271
56MP0003880_abnormal_central_pattern1.44588276
57MP0006276_abnormal_autonomic_nervous1.42298724
58MP0003121_genomic_imprinting1.41905453
59MP0009379_abnormal_foot_pigmentation1.39819591
60MP0001905_abnormal_dopamine_level1.39128014
61MP0005266_abnormal_metabolism1.38507913
62MP0005253_abnormal_eye_physiology1.37143038
63MP0002938_white_spotting1.36041711
64MP0003786_premature_aging1.33446831
65MP0005670_abnormal_white_adipose1.32976348
66MP0005332_abnormal_amino_acid1.32955899
67MP0004270_analgesia1.30197892
68MP0010630_abnormal_cardiac_muscle1.27828072
69MP0001485_abnormal_pinna_reflex1.26270133
70MP0000013_abnormal_adipose_tissue1.26160349
71MP0003635_abnormal_synaptic_transmissio1.25756998
72MP0002557_abnormal_social/conspecific_i1.25502568
73MP0002572_abnormal_emotion/affect_behav1.25359910
74MP0005535_abnormal_body_temperature1.25353614
75MP0002653_abnormal_ependyma_morphology1.23699774
76MP0004859_abnormal_synaptic_plasticity1.22124279
77MP0001486_abnormal_startle_reflex1.21493526
78MP0004142_abnormal_muscle_tone1.20417934
79MP0003718_maternal_effect1.19855913
80MP0002736_abnormal_nociception_after1.19567704
81MP0000230_abnormal_systemic_arterial1.16663144
82MP0002127_abnormal_cardiovascular_syste1.15072072
83MP0003136_yellow_coat_color1.14538724
84MP0002876_abnormal_thyroid_physiology1.13828501
85MP0004133_heterotaxia1.12246890
86MP0000631_abnormal_neuroendocrine_gland1.12240424
87MP0008872_abnormal_physiological_respon1.11977861
88MP0002733_abnormal_thermal_nociception1.11896525
89MP0004233_abnormal_muscle_weight1.09942574
90MP0001986_abnormal_taste_sensitivity1.09237493
91MP0002160_abnormal_reproductive_system1.09081323
92MP0002063_abnormal_learning/memory/cond1.08623396
93MP0001764_abnormal_homeostasis1.05158261
94MP0005075_abnormal_melanosome_morpholog1.04863663
95MP0004742_abnormal_vestibular_system1.04199708
96MP0002735_abnormal_chemical_nociception1.02252924
97MP0002822_catalepsy1.01714710
98MP0001727_abnormal_embryo_implantation1.01425491
99MP0005636_abnormal_mineral_homeostasis1.00904996
100MP0000778_abnormal_nervous_system1.00658869
101MP0002277_abnormal_respiratory_mucosa1.00393847
102MP0002184_abnormal_innervation0.98625995
103MP0002638_abnormal_pupillary_reflex0.98596640
104MP0005083_abnormal_biliary_tract0.96004749
105MP0005451_abnormal_body_composition0.95425473
106MP0002272_abnormal_nervous_system0.94733955
107MP0002234_abnormal_pharynx_morphology0.94694827
108MP0005165_increased_susceptibility_to0.94513705
109MP0005389_reproductive_system_phenotype0.94226996
110MP0002752_abnormal_somatic_nervous0.94143210
111MP0002090_abnormal_vision0.94108982
112MP0002095_abnormal_skin_pigmentation0.92199512
113MP0005584_abnormal_enzyme/coenzyme_acti0.91907935
114MP0000343_altered_response_to0.90995047
115MP0003828_pulmonary_edema0.90786863
116MP0009046_muscle_twitch0.90580519
117MP0005386_behavior/neurological_phenoty0.90324531
118MP0004924_abnormal_behavior0.90324531
119MP0004885_abnormal_endolymph0.90020578
120MP0003122_maternal_imprinting0.86674414
121MP0002229_neurodegeneration0.86485259
122MP0001756_abnormal_urination0.85836061
123MP0001968_abnormal_touch/_nociception0.85427157
124MP0002882_abnormal_neuron_morphology0.83448937
125MP0005376_homeostasis/metabolism_phenot0.82841793
126MP0009697_abnormal_copulation0.82326876
127MP0004811_abnormal_neuron_physiology0.82105970
128MP0002751_abnormal_autonomic_nervous0.80572011
129MP0001919_abnormal_reproductive_system0.79306959
130MP0005319_abnormal_enzyme/_coenzyme0.78852681
131MP0009643_abnormal_urine_homeostasis0.78684750
132MP0000955_abnormal_spinal_cord0.78449551
133MP0001293_anophthalmia0.77950790
134MP0002909_abnormal_adrenal_gland0.76590570
135MP0005084_abnormal_gallbladder_morpholo0.75613997
136MP0003950_abnormal_plasma_membrane0.74821268
137MP0005666_abnormal_adipose_tissue0.74474069
138MP0001440_abnormal_grooming_behavior0.72207852
139MP0005085_abnormal_gallbladder_physiolo0.71864515
140MP0010386_abnormal_urinary_bladder0.71709412
141MP0002078_abnormal_glucose_homeostasis0.71567944
142MP0000358_abnormal_cell_content/0.69790182
143MP0003656_abnormal_erythrocyte_physiolo0.69563223
144MP0000372_irregular_coat_pigmentation0.69069900
145MP0002064_seizures0.69052550
146MP0002139_abnormal_hepatobiliary_system0.67267595
147MP0002734_abnormal_mechanical_nocicepti0.67190666
148MP0005360_urolithiasis0.66640718
149MP0004510_myositis0.65253687
150MP0009745_abnormal_behavioral_response0.64618897
151MP0008875_abnormal_xenobiotic_pharmacok0.63494819
152MP0001765_abnormal_ion_homeostasis0.62549693
153MP0001984_abnormal_olfaction0.60278271
154MP0003567_abnormal_fetal_cardiomyocyte0.59322997
155MP0002067_abnormal_sensory_capabilities0.58712501
156MP0008004_abnormal_stomach_pH0.50957846
157MP0002971_abnormal_brown_adipose0.50255421
158MP0001970_abnormal_pain_threshold0.49451072

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.20548394
2Abnormal mitochondria in muscle tissue (HP:0008316)6.86461531
3Mitochondrial inheritance (HP:0001427)6.22747673
4Acute encephalopathy (HP:0006846)6.20054045
5Progressive macrocephaly (HP:0004481)5.97374990
6Hepatocellular necrosis (HP:0001404)5.82553210
7Hepatic necrosis (HP:0002605)5.77817860
8Increased CSF lactate (HP:0002490)5.63820347
9Cerebral edema (HP:0002181)4.77846186
10Lactic acidosis (HP:0003128)4.28318301
11Increased serum pyruvate (HP:0003542)4.25970957
12Abnormality of glycolysis (HP:0004366)4.25970957
13Exercise intolerance (HP:0003546)4.18188952
14Sudden death (HP:0001699)4.17567663
15Respiratory failure (HP:0002878)4.14560369
16Lipid accumulation in hepatocytes (HP:0006561)4.08409988
17Increased hepatocellular lipid droplets (HP:0006565)4.07464398
18Increased intramyocellular lipid droplets (HP:0012240)4.00739180
19Increased muscle lipid content (HP:0009058)3.95229235
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.87735517
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.87735517
22Calf muscle hypertrophy (HP:0008981)3.75153981
23Increased serum lactate (HP:0002151)3.70059282
24Exercise-induced muscle cramps (HP:0003710)3.63712302
25Palpitations (HP:0001962)3.59396677
26Muscle hypertrophy of the lower extremities (HP:0008968)3.58732577
27Myoglobinuria (HP:0002913)3.54590853
28Pheochromocytoma (HP:0002666)3.54360368
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.51373354
30Neuroendocrine neoplasm (HP:0100634)3.47884868
31Optic disc pallor (HP:0000543)3.42185650
32Exercise-induced myalgia (HP:0003738)3.38317331
33Renal Fanconi syndrome (HP:0001994)3.27714923
34Leukodystrophy (HP:0002415)3.26748614
35Myokymia (HP:0002411)3.22124609
36Ventricular tachycardia (HP:0004756)3.21951010
37Rhabdomyolysis (HP:0003201)3.10784513
38Abnormal number of erythroid precursors (HP:0012131)3.07581562
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.02641497
40Conjunctival hamartoma (HP:0100780)2.98128134
41Abnormality of cells of the erythroid lineage (HP:0012130)2.93557902
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.91012634
43Dicarboxylic aciduria (HP:0003215)2.91012634
44Lipoatrophy (HP:0100578)2.88828369
45Lethargy (HP:0001254)2.88092047
46Generalized aminoaciduria (HP:0002909)2.84530215
47CNS demyelination (HP:0007305)2.83777094
48Atrial fibrillation (HP:0005110)2.83107569
493-Methylglutaconic aciduria (HP:0003535)2.79069740
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77474520
51Abnormality of alanine metabolism (HP:0010916)2.77474520
52Hyperalaninemia (HP:0003348)2.77474520
53Ketoacidosis (HP:0001993)2.75367765
54Abnormality of fatty-acid metabolism (HP:0004359)2.73979890
55Abnormality of urine glucose concentration (HP:0011016)2.71429134
56Glycosuria (HP:0003076)2.71429134
57Muscle fiber splitting (HP:0003555)2.71379855
58Abnormality of the calf musculature (HP:0001430)2.70673007
59Respiratory difficulties (HP:0002880)2.65909796
60Supraventricular tachycardia (HP:0004755)2.65906545
61Primary atrial arrhythmia (HP:0001692)2.62842378
62Reticulocytopenia (HP:0001896)2.61281593
63Supraventricular arrhythmia (HP:0005115)2.56366608
64Ragged-red muscle fibers (HP:0003200)2.53761287
65Exertional dyspnea (HP:0002875)2.53535923
66Dilated cardiomyopathy (HP:0001644)2.53265476
67Emotional lability (HP:0000712)2.50181697
68Hypoglycemic coma (HP:0001325)2.46309871
69Molar tooth sign on MRI (HP:0002419)2.42599828
70Abnormality of midbrain morphology (HP:0002418)2.42599828
71Pancreatic fibrosis (HP:0100732)2.41780516
72Neoplasm of the adrenal gland (HP:0100631)2.41734848
73Macrocytic anemia (HP:0001972)2.41328319
74Aplastic anemia (HP:0001915)2.40581611
75Medial flaring of the eyebrow (HP:0010747)2.40563985
76Syncope (HP:0001279)2.38252009
77Vomiting (HP:0002013)2.35939942
78Myotonia (HP:0002486)2.34498955
79Pancreatic cysts (HP:0001737)2.32222443
80Esophageal neoplasm (HP:0100751)2.31901396
81Neoplasm of head and neck (HP:0012288)2.31901396
82Proximal tubulopathy (HP:0000114)2.30711328
83Nausea (HP:0002018)2.30045413
84Prolonged QT interval (HP:0001657)2.30028665
85X-linked dominant inheritance (HP:0001423)2.27909290
86Abnormality of renal resorption (HP:0011038)2.27626812
87Type I transferrin isoform profile (HP:0003642)2.23392511
88Methylmalonic aciduria (HP:0012120)2.20358102
89Cerebral hypomyelination (HP:0006808)2.20179045
90Abnormality of the anterior horn cell (HP:0006802)2.18355418
91Degeneration of anterior horn cells (HP:0002398)2.18355418
92Muscle stiffness (HP:0003552)2.15299436
93Ketosis (HP:0001946)2.14189489
94Hyperphosphaturia (HP:0003109)2.12127984
95Methylmalonic acidemia (HP:0002912)2.11499079
96EMG: myopathic abnormalities (HP:0003458)2.11249112
97Gliosis (HP:0002171)2.10597183
98Poor suck (HP:0002033)2.10029336
99Microvesicular hepatic steatosis (HP:0001414)2.09995776
100True hermaphroditism (HP:0010459)2.05688801
101Metabolic acidosis (HP:0001942)2.05642569
102Abnormality of the labia minora (HP:0012880)2.02912021
103Nephronophthisis (HP:0000090)2.02691272
104Subaortic stenosis (HP:0001682)2.02061424
105Abnormality of the left ventricular outflow tract (HP:0011103)2.02061424
106Hyperglycinemia (HP:0002154)1.99002607
107Left ventricular hypertrophy (HP:0001712)1.98250843
108Gait imbalance (HP:0002141)1.95645358
109Hyperglycinuria (HP:0003108)1.89789787
110Congenital primary aphakia (HP:0007707)1.89452882
111Limb dystonia (HP:0002451)1.89431921
112Ventricular arrhythmia (HP:0004308)1.89149656
113Asymmetric septal hypertrophy (HP:0001670)1.88817693
114Ventricular fibrillation (HP:0001663)1.85523365
115Neoplasm of the peripheral nervous system (HP:0100007)1.83173417
116Hyperammonemia (HP:0001987)1.81759558
117Hypothermia (HP:0002045)1.81588712
118Tinnitus (HP:0000360)1.81498987
119Abnormal protein glycosylation (HP:0012346)1.80859634
120Abnormal glycosylation (HP:0012345)1.80859634
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80859634
122Abnormal protein N-linked glycosylation (HP:0012347)1.80859634
123Nephrogenic diabetes insipidus (HP:0009806)1.79158231
124Type 2 muscle fiber atrophy (HP:0003554)1.79112848
125Colon cancer (HP:0003003)1.78094187
126Pancytopenia (HP:0001876)1.77638243
127Cerebral hemorrhage (HP:0001342)1.77413209
128Progressive microcephaly (HP:0000253)1.77130439
129Aplasia/hypoplasia of the uterus (HP:0008684)1.76262227
130Abnormality of the vocal cords (HP:0008777)1.75812129
131Sclerocornea (HP:0000647)1.75652614
132Blindness (HP:0000618)1.75146308
133Abnormal urine phosphate concentration (HP:0012599)1.73918373
134Gout (HP:0001997)1.72745427
135Abnormal EKG (HP:0003115)1.72241246
136Testicular atrophy (HP:0000029)1.71658895
137Hyporeflexia of lower limbs (HP:0002600)1.70496880
138Right ventricular cardiomyopathy (HP:0011663)1.69932286
139CNS hypomyelination (HP:0003429)1.67444504
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.66360264
141Congenital stationary night blindness (HP:0007642)1.62462282
142Congenital, generalized hypertrichosis (HP:0004540)1.62042830
143Oral leukoplakia (HP:0002745)1.61573406
144Muscle fiber atrophy (HP:0100295)1.60257070
145Delayed CNS myelination (HP:0002188)1.57008359
146Abnormality of aromatic amino acid family metabolism (HP:0004338)1.55130359
147Renal cortical cysts (HP:0000803)1.54804685
148Polyphagia (HP:0002591)1.53464152
149Retinal dysplasia (HP:0007973)1.52553172
150Muscular hypotonia of the trunk (HP:0008936)1.51791003
151Hyperinsulinemic hypoglycemia (HP:0000825)1.51644484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.23048158
2MYLK4.09979920
3VRK24.09213676
4BCKDK3.83219430
5PDK33.30670982
6PDK43.30670982
7NME13.27028652
8MAP3K122.49297938
9STK162.47762305
10NEK12.43090108
11NME22.41764322
12MUSK2.26733178
13MAP4K22.25640767
14PDK22.17346407
15WNK42.16497435
16PHKG22.13821784
17PHKG12.13821784
18TTN2.11826862
19TESK22.09885029
20LMTK22.02622831
21PINK11.89483325
22ARAF1.82223244
23TRIM281.80227573
24GRK71.76703610
25EIF2AK11.73897032
26BUB11.71942550
27NUAK11.59322350
28PIK3CA1.52605224
29STK241.52495144
30WNK31.52247055
31ZAK1.49282566
32CSNK1G31.46032711
33CSNK1G21.43079994
34LIMK11.40699899
35OXSR11.33002422
36ILK1.31994352
37BRAF1.27299210
38CDC71.22438738
39GRK11.20284702
40MARK11.19231188
41DAPK21.16586756
42EIF2AK31.16264140
43STK391.14960596
44CAMK2D1.14077254
45STK38L1.13225705
46CSNK1G11.12269841
47EPHA41.12020487
48PLK31.11218173
49DAPK31.10643741
50VRK11.06408559
51FRK1.06142343
52TXK1.04848293
53TIE11.03243433
54ABL21.02115094
55CSNK1A1L0.99631689
56MAP3K110.99163893
57CCNB10.93101635
58CASK0.92769988
59KDR0.91871648
60MAP2K70.91136074
61PBK0.90471672
62TESK10.87989759
63MAPK130.85714784
64GRK50.83618869
65TNIK0.82177590
66CAMK2G0.82030869
67MST40.80385642
68RPS6KA50.78967545
69CAMK2A0.75688482
70PLK10.74077082
71PLK20.73139003
72CDK190.71569191
73PIM20.68632378
74BCR0.68494166
75CAMK2B0.65859741
76MAP2K40.62635102
77MAPK120.62561311
78PRKACA0.59774683
79MINK10.59435473
80DAPK10.59388211
81PLK40.58782923
82WEE10.58616456
83MAPKAPK30.56695228
84MAP3K40.55323555
85BMPR20.53744025
86PRKCE0.53437463
87CSNK1A10.52681935
88PASK0.51822090
89TAOK30.51659746
90TSSK60.51146473
91SRPK10.51135702
92DYRK20.50963504
93DYRK30.50953480
94ADRBK10.49679460
95BMPR1B0.49114867
96PIK3CG0.47146129
97PRKCQ0.46735279
98ATR0.46230721
99LRRK20.46014565
100PRKCG0.45329259
101CDK80.44632847
102PAK30.44510040
103TAF10.44486890
104ADRBK20.43972825
105NTRK30.43892546
106INSRR0.43862450
107ROCK10.43317157
108ROCK20.41847525
109CSNK1E0.41737548
110NTRK20.41673747
111CDK140.41667634
112PTK2B0.41242332
113AURKA0.40305342
114TLK10.40157063
115CSNK2A10.38075277
116AKT30.36239170
117PRKACB0.35805028
118MAP3K50.34855613
119UHMK10.34619653
120BRSK20.33316672
121FLT30.33194472
122BRSK10.32381816
123MAP2K60.32178186
124RPS6KL10.32105020
125RPS6KC10.32105020
126PKN10.32054585
127CAMKK20.31883178
128CDC42BPA0.31038174
129PRKACG0.29586807
130CSNK2A20.29107967
131CAMK10.28979689
132PKN20.25831751

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.89112793
2Parkinsons disease_Homo sapiens_hsa050125.23252169
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.87289178
4Alzheimers disease_Homo sapiens_hsa050103.76905332
5Huntingtons disease_Homo sapiens_hsa050163.60012315
6Cardiac muscle contraction_Homo sapiens_hsa042603.42938138
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.28113201
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.08730758
9Proteasome_Homo sapiens_hsa030503.00591097
10Propanoate metabolism_Homo sapiens_hsa006402.55145828
11Pyruvate metabolism_Homo sapiens_hsa006202.21457296
12Ribosome_Homo sapiens_hsa030102.16999822
13Carbon metabolism_Homo sapiens_hsa012002.10856450
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86845830
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81394790
16Protein export_Homo sapiens_hsa030601.72251606
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67116182
18Collecting duct acid secretion_Homo sapiens_hsa049661.63324022
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62677191
20Fatty acid degradation_Homo sapiens_hsa000711.62610807
21Fatty acid elongation_Homo sapiens_hsa000621.61143109
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40598230
23RNA polymerase_Homo sapiens_hsa030201.38939303
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34799276
25Butanoate metabolism_Homo sapiens_hsa006501.34083091
26Fatty acid metabolism_Homo sapiens_hsa012121.27676127
27Phototransduction_Homo sapiens_hsa047441.16721255
28Sulfur metabolism_Homo sapiens_hsa009201.16599642
29Biosynthesis of amino acids_Homo sapiens_hsa012301.11412503
30Vibrio cholerae infection_Homo sapiens_hsa051101.00847293
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97082302
32Peroxisome_Homo sapiens_hsa041460.96484617
33Nicotine addiction_Homo sapiens_hsa050330.95448856
34Phenylalanine metabolism_Homo sapiens_hsa003600.94339129
35Basal transcription factors_Homo sapiens_hsa030220.93367719
36Dilated cardiomyopathy_Homo sapiens_hsa054140.92002653
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.90308137
38Pyrimidine metabolism_Homo sapiens_hsa002400.89695020
39* Metabolic pathways_Homo sapiens_hsa011000.89673912
40One carbon pool by folate_Homo sapiens_hsa006700.87502644
41Fructose and mannose metabolism_Homo sapiens_hsa000510.85899563
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83831248
43Fanconi anemia pathway_Homo sapiens_hsa034600.82002036
44beta-Alanine metabolism_Homo sapiens_hsa004100.77483496
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76530542
46Synaptic vesicle cycle_Homo sapiens_hsa047210.73273291
47Glutathione metabolism_Homo sapiens_hsa004800.71767264
48Tyrosine metabolism_Homo sapiens_hsa003500.71579863
49RNA transport_Homo sapiens_hsa030130.70364968
50Galactose metabolism_Homo sapiens_hsa000520.66380736
51Tryptophan metabolism_Homo sapiens_hsa003800.62520381
52Arginine and proline metabolism_Homo sapiens_hsa003300.61916453
53Purine metabolism_Homo sapiens_hsa002300.61739487
54Steroid biosynthesis_Homo sapiens_hsa001000.58313546
55Nitrogen metabolism_Homo sapiens_hsa009100.57419749
56Pentose phosphate pathway_Homo sapiens_hsa000300.52842959
57Vitamin B6 metabolism_Homo sapiens_hsa007500.51127242
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49840921
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49434376
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49227554
61PPAR signaling pathway_Homo sapiens_hsa033200.48192285
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47890734
63Folate biosynthesis_Homo sapiens_hsa007900.47652487
64Non-homologous end-joining_Homo sapiens_hsa034500.45845107
65Primary immunodeficiency_Homo sapiens_hsa053400.45565279
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.44994121
67Caffeine metabolism_Homo sapiens_hsa002320.44178079
68Starch and sucrose metabolism_Homo sapiens_hsa005000.42611170
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42525919
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41648397
71Sulfur relay system_Homo sapiens_hsa041220.40905796
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39266590
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38784005
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37732364
75Morphine addiction_Homo sapiens_hsa050320.36389663
76Selenocompound metabolism_Homo sapiens_hsa004500.36049489
77Linoleic acid metabolism_Homo sapiens_hsa005910.34180022
78DNA replication_Homo sapiens_hsa030300.33513539
79Type I diabetes mellitus_Homo sapiens_hsa049400.31908410
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30277927
81Mismatch repair_Homo sapiens_hsa034300.30198523
82Olfactory transduction_Homo sapiens_hsa047400.29753182
83Arachidonic acid metabolism_Homo sapiens_hsa005900.28876992
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28874944
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27688901
86Regulation of autophagy_Homo sapiens_hsa041400.26153457
87Rheumatoid arthritis_Homo sapiens_hsa053230.25379579
88Glucagon signaling pathway_Homo sapiens_hsa049220.24722603
89Retinol metabolism_Homo sapiens_hsa008300.24526419
90Dopaminergic synapse_Homo sapiens_hsa047280.24203789
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23584275
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.21628976
93Oocyte meiosis_Homo sapiens_hsa041140.21404959
94Circadian entrainment_Homo sapiens_hsa047130.21328069
95Nucleotide excision repair_Homo sapiens_hsa034200.20706154
96Phagosome_Homo sapiens_hsa041450.20489475
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.19796649
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19573425
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19275185
100Serotonergic synapse_Homo sapiens_hsa047260.19224316
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19152918
102Calcium signaling pathway_Homo sapiens_hsa040200.18609385
103Alcoholism_Homo sapiens_hsa050340.18583510
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18285343
105Histidine metabolism_Homo sapiens_hsa003400.17918895
106Fat digestion and absorption_Homo sapiens_hsa049750.15770205
107Chemical carcinogenesis_Homo sapiens_hsa052040.15537485
108RNA degradation_Homo sapiens_hsa030180.14527099
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.13965726
110Arginine biosynthesis_Homo sapiens_hsa002200.13917727
111Spliceosome_Homo sapiens_hsa030400.13651764
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12663202
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12373783
114Taste transduction_Homo sapiens_hsa047420.11151488
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11090106
116Homologous recombination_Homo sapiens_hsa034400.10278743
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.10166959
118Glycerolipid metabolism_Homo sapiens_hsa005610.08207722
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.07762568
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07317388
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06499614
122GABAergic synapse_Homo sapiens_hsa047270.05694744
123Base excision repair_Homo sapiens_hsa034100.05352771
124Insulin secretion_Homo sapiens_hsa049110.05219169
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.04930570

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