NDUFB8P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)9.58832701
2cytidine metabolic process (GO:0046087)9.58832701
3cytidine catabolic process (GO:0006216)9.58832701
4pyrimidine ribonucleoside catabolic process (GO:0046133)8.50919588
5DNA deamination (GO:0045006)8.04087862
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.95927709
7negative regulation by host of viral transcription (GO:0043922)5.60326520
8eosinophil chemotaxis (GO:0048245)5.48842261
9eosinophil migration (GO:0072677)4.94939392
10T cell migration (GO:0072678)4.56394879
11positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.51169439
12positive regulation of interleukin-8 secretion (GO:2000484)4.50898281
13sequestering of actin monomers (GO:0042989)4.42158012
14positive regulation of natural killer cell mediated immunity (GO:0002717)4.40334709
15regulation of chronic inflammatory response (GO:0002676)4.39619813
16regulation of activation of Janus kinase activity (GO:0010533)4.35423475
17negative regulation of T cell apoptotic process (GO:0070233)4.33782770
18negative regulation of viral genome replication (GO:0045071)4.29313620
19regulation of regulatory T cell differentiation (GO:0045589)4.13040204
20pyrimidine nucleoside catabolic process (GO:0046135)4.11569869
21cellular response to interleukin-15 (GO:0071350)3.99053917
22positive regulation of T cell chemotaxis (GO:0010820)3.90108318
23regulation of T cell chemotaxis (GO:0010819)3.90108318
24macrophage chemotaxis (GO:0048246)3.89515563
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.87874949
26positive regulation of T cell apoptotic process (GO:0070234)3.87363643
27DNA demethylation (GO:0080111)3.85178338
28regulation of lymphocyte chemotaxis (GO:1901623)3.84216840
29positive regulation of monocyte chemotaxis (GO:0090026)3.84133995
30positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.75230964
31positive regulation of calcium-mediated signaling (GO:0050850)3.66756344
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.66550819
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.66550819
34regulation of synapse structural plasticity (GO:0051823)3.63792052
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.55131720
36regulation of natural killer cell mediated immunity (GO:0002715)3.55131720
37DNA dealkylation (GO:0035510)3.53187685
38cytolysis (GO:0019835)3.52247561
39positive regulation of translational initiation (GO:0045948)3.51703297
40regulation of interleukin-8 secretion (GO:2000482)3.50121491
41adaptation of signaling pathway (GO:0023058)3.47021863
42Arp2/3 complex-mediated actin nucleation (GO:0034314)3.44746656
43positive regulation of cell killing (GO:0031343)3.37971548
44pyrimidine-containing compound catabolic process (GO:0072529)3.32099731
45negative regulation of calcium ion transport into cytosol (GO:0010523)3.30676766
46monocyte chemotaxis (GO:0002548)3.30511618
47regulation of gamma-delta T cell differentiation (GO:0045586)3.29991191
48response to interleukin-15 (GO:0070672)3.29794824
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24537882
50regulation of leukocyte mediated cytotoxicity (GO:0001910)3.21649286
51actin nucleation (GO:0045010)3.19528329
52positive thymic T cell selection (GO:0045059)3.19485638
53platelet dense granule organization (GO:0060155)3.16533948
54ncRNA 3-end processing (GO:0043628)3.12802662
55positive regulation of lymphocyte apoptotic process (GO:0070230)3.11497829
56protein neddylation (GO:0045116)3.08997465
57positive regulation of lymphocyte migration (GO:2000403)3.08260002
58positive T cell selection (GO:0043368)3.07167736
59negative regulation of lymphocyte apoptotic process (GO:0070229)3.05530327
60negative regulation of viral transcription (GO:0032897)3.04364289
61positive regulation of uterine smooth muscle contraction (GO:0070474)3.01036463
62positive regulation of interleukin-1 beta secretion (GO:0050718)2.96347593
63regulation of cell killing (GO:0031341)2.96017822
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.95826972
65regulation of T cell apoptotic process (GO:0070232)2.94230243
66positive regulation of gamma-delta T cell activation (GO:0046645)2.91642292
67regulation of viral genome replication (GO:0045069)2.91002348
68negative regulation of T cell differentiation in thymus (GO:0033085)2.90540730
69response to pheromone (GO:0019236)2.90487332
70regulation of mononuclear cell migration (GO:0071675)2.89759864
71positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89731880
72respiratory electron transport chain (GO:0022904)2.89290002
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89207108
74regulation of calcium-mediated signaling (GO:0050848)2.88834628
75regulation of chemokine-mediated signaling pathway (GO:0070099)2.88363350
76electron transport chain (GO:0022900)2.86951741
77positive regulation of tolerance induction (GO:0002645)2.86551636
78protein complex biogenesis (GO:0070271)2.85483633
79modulation by host of symbiont transcription (GO:0052472)2.84981516
80modulation by host of viral transcription (GO:0043921)2.84981516
81mast cell activation involved in immune response (GO:0002279)2.84692121
82mast cell degranulation (GO:0043303)2.84692121
83negative T cell selection (GO:0043383)2.84182954
84positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.81132455
85regulation of interleukin-2 biosynthetic process (GO:0045076)2.80963752
86regulation of cellular amino acid metabolic process (GO:0006521)2.79676265
87response to xenobiotic stimulus (GO:0009410)2.79369679
88positive regulation of interleukin-1 secretion (GO:0050716)2.77445050
89modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.76774319
90establishment of protein localization to mitochondrial membrane (GO:0090151)2.76264078
91regulation of interleukin-1 beta secretion (GO:0050706)2.76026669
92dendritic cell chemotaxis (GO:0002407)2.73072078
93negative regulation of viral process (GO:0048525)2.72199461
94regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.71138501
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69253320
96tachykinin receptor signaling pathway (GO:0007217)2.68377961
97regulation of T cell receptor signaling pathway (GO:0050856)2.66175216
98lymphocyte migration (GO:0072676)2.65251146
99regulation of T cell tolerance induction (GO:0002664)2.64273955
100metallo-sulfur cluster assembly (GO:0031163)2.63877583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.09362598
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.33449585
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02301149
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68049337
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.63226176
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54300026
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.49903378
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45356959
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39413204
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28363448
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11131999
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.08400333
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06995148
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06892168
15ZNF274_21170338_ChIP-Seq_K562_Hela2.04758695
16BP1_19119308_ChIP-ChIP_Hs578T_Human10.2439543
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98277237
18VDR_23849224_ChIP-Seq_CD4+_Human1.95424311
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95146629
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.89222737
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.88328605
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81985199
23MYB_26560356_Chip-Seq_TH2_Human1.76366626
24GATA3_27048872_Chip-Seq_THYMUS_Human1.70833243
25EZH2_22144423_ChIP-Seq_EOC_Human1.68981964
26VDR_22108803_ChIP-Seq_LS180_Human1.68739265
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60549414
28FOXP3_21729870_ChIP-Seq_TREG_Human1.59494961
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57376586
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54663598
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49905245
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.46345315
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.46295098
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45455561
35GATA3_26560356_Chip-Seq_TH2_Human1.43246397
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34851595
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.34716193
38TP53_22573176_ChIP-Seq_HFKS_Human1.31516660
39PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29182448
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22424524
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21711837
42TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18867121
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18736294
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16427259
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15104524
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13966596
47MYB_26560356_Chip-Seq_TH1_Human1.13362975
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13229748
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.11430451
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11430451
51TAF2_19829295_ChIP-Seq_ESCs_Human1.09889589
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09863968
53ER_23166858_ChIP-Seq_MCF-7_Human1.08904848
54RUNX_20019798_ChIP-Seq_JUKART_Human1.07414927
55GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07396014
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07382410
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07080034
58HTT_18923047_ChIP-ChIP_STHdh_Human1.04911448
59IGF1R_20145208_ChIP-Seq_DFB_Human1.04557387
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04164725
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.03851175
62GBX2_23144817_ChIP-Seq_PC3_Human1.03722804
63ELK1_19687146_ChIP-ChIP_HELA_Human1.03249692
64MAF_26560356_Chip-Seq_TH2_Human1.01242076
65NCOR_22424771_ChIP-Seq_293T_Human0.98920305
66HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98419549
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97658002
68POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97106793
69FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96588032
70NANOG_20526341_ChIP-Seq_ESCs_Human0.96586971
71P300_19829295_ChIP-Seq_ESCs_Human0.96241527
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95206745
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94906982
74EWS_26573619_Chip-Seq_HEK293_Human0.94816831
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94452565
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93042812
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92912819
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92578396
79NFE2_27457419_Chip-Seq_LIVER_Mouse0.91820597
80DCP1A_22483619_ChIP-Seq_HELA_Human0.90970660
81UTX_26944678_Chip-Seq_JUKART_Human0.90397780
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89886861
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89834712
84MYC_18940864_ChIP-ChIP_HL60_Human0.89696238
85AR_20517297_ChIP-Seq_VCAP_Human0.88848276
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88184915
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86975556
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.86519187
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85553538
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85225889
91YY1_22570637_ChIP-Seq_MALME-3M_Human0.84070020
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83476076
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82908603
94BCL6_27268052_Chip-Seq_Bcells_Human0.82660447
95HOXB7_26014856_ChIP-Seq_BT474_Human0.82559458
96PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82523507
97P53_21459846_ChIP-Seq_SAOS-2_Human0.80982632
98SOX2_19829295_ChIP-Seq_ESCs_Human0.80602773
99NANOG_19829295_ChIP-Seq_ESCs_Human0.80602773
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80574149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.66632769
2MP0009785_altered_susceptibility_to3.14269069
3MP0001835_abnormal_antigen_presentation2.68911080
4MP0006082_CNS_inflammation2.60450659
5MP0003866_abnormal_defecation2.50639411
6MP0002837_dystrophic_cardiac_calcinosis2.33704197
7MP0009333_abnormal_splenocyte_physiolog2.24877968
8MP0004145_abnormal_muscle_electrophysio2.22511955
9MP0005000_abnormal_immune_tolerance2.18873585
10MP0004147_increased_porphyrin_level2.18315237
11MP0001800_abnormal_humoral_immune2.17220793
12MP0003763_abnormal_thymus_physiology2.13214130
13MP0002148_abnormal_hypersensitivity_rea2.09847263
14MP0005645_abnormal_hypothalamus_physiol1.99972875
15MP0003787_abnormal_imprinting1.97571858
16MP0002723_abnormal_immune_serum1.96939501
17MP0001873_stomach_inflammation1.95891372
18MP0008872_abnormal_physiological_respon1.94057534
19MP0002420_abnormal_adaptive_immunity1.90763316
20MP0002138_abnormal_hepatobiliary_system1.88755605
21MP0005025_abnormal_response_to1.86867250
22MP0003878_abnormal_ear_physiology1.80722255
23MP0005377_hearing/vestibular/ear_phenot1.80722255
24MP0001819_abnormal_immune_cell1.80630525
25MP0003786_premature_aging1.70679067
26MP0002163_abnormal_gland_morphology1.65885537
27MP0008877_abnormal_DNA_methylation1.65059633
28MP0010155_abnormal_intestine_physiology1.62156046
29MP0002398_abnormal_bone_marrow1.61527943
30MP0001968_abnormal_touch/_nociception1.59180926
31MP0000716_abnormal_immune_system1.56916854
32MP0002876_abnormal_thyroid_physiology1.56713158
33MP0002405_respiratory_system_inflammati1.53292868
34MP0003195_calcinosis1.51874189
35MP0005310_abnormal_salivary_gland1.51749141
36MP0000372_irregular_coat_pigmentation1.51115857
37MP0000689_abnormal_spleen_morphology1.47927106
38MP0003137_abnormal_impulse_conducting1.46422536
39MP0006036_abnormal_mitochondrial_physio1.45794267
40MP0004885_abnormal_endolymph1.42759405
41MP0001348_abnormal_lacrimal_gland1.42690531
42MP0001790_abnormal_immune_system1.42325162
43MP0005387_immune_system_phenotype1.42325162
44MP0002722_abnormal_immune_system1.42226484
45MP0002452_abnormal_antigen_presenting1.39697866
46MP0002693_abnormal_pancreas_physiology1.36005284
47MP0001845_abnormal_inflammatory_respons1.32727562
48MP0004134_abnormal_chest_morphology1.28616486
49MP0006072_abnormal_retinal_apoptosis1.23905081
50MP0002429_abnormal_blood_cell1.22975138
51MP0000703_abnormal_thymus_morphology1.20410384
52MP0003045_fibrosis1.17658904
53MP0008875_abnormal_xenobiotic_pharmacok1.15772179
54MP0005551_abnormal_eye_electrophysiolog1.15066113
55MP0001905_abnormal_dopamine_level1.11568250
56MP0003448_altered_tumor_morphology1.10928428
57MP0001485_abnormal_pinna_reflex1.10693245
58MP0002736_abnormal_nociception_after1.10057096
59MP0001984_abnormal_olfaction1.08974709
60MP0002102_abnormal_ear_morphology1.08288659
61MP0006035_abnormal_mitochondrial_morpho1.06471220
62MP0002933_joint_inflammation1.06434602
63MP0005379_endocrine/exocrine_gland_phen1.06113082
64MP0005636_abnormal_mineral_homeostasis1.05046307
65MP0002733_abnormal_thermal_nociception1.04516693
66MP0008469_abnormal_protein_level1.02744780
67MP0001919_abnormal_reproductive_system1.02539111
68MP0010386_abnormal_urinary_bladder1.02269858
69MP0010307_abnormal_tumor_latency1.00062790
70MP0004742_abnormal_vestibular_system0.98055373
71MP0003436_decreased_susceptibility_to0.98003452
72MP0002166_altered_tumor_susceptibility0.95731472
73MP0001970_abnormal_pain_threshold0.95210950
74MP0002277_abnormal_respiratory_mucosa0.93923399
75MP0009763_increased_sensitivity_to0.92840851
76MP0002419_abnormal_innate_immunity0.92036488
77MP0000685_abnormal_immune_system0.91042842
78MP0005253_abnormal_eye_physiology0.90855571
79MP0006276_abnormal_autonomic_nervous0.90575913
80MP0009764_decreased_sensitivity_to0.87632594
81MP0005464_abnormal_platelet_physiology0.86047688
82MP0002751_abnormal_autonomic_nervous0.83821633
83MP0002019_abnormal_tumor_incidence0.83435821
84MP0002638_abnormal_pupillary_reflex0.82676610
85MP0003186_abnormal_redox_activity0.80326013
86MP0009765_abnormal_xenobiotic_induced0.79503697
87MP0008789_abnormal_olfactory_epithelium0.77738045
88MP0003880_abnormal_central_pattern0.74730207
89MP0004142_abnormal_muscle_tone0.74697857
90MP0005083_abnormal_biliary_tract0.73944154
91MP0003011_delayed_dark_adaptation0.73318685
92MP0005084_abnormal_gallbladder_morpholo0.72755515
93MP0008995_early_reproductive_senescence0.72749431
94MP0002006_tumorigenesis0.72012768
95MP0009745_abnormal_behavioral_response0.70540676
96MP0005360_urolithiasis0.69361559
97MP0000569_abnormal_digit_pigmentation0.66723723
98MP0001119_abnormal_female_reproductive0.66202868
99MP0002067_abnormal_sensory_capabilities0.65548965
100MP0005174_abnormal_tail_pigmentation0.65263412

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)5.61973347
2Aplastic anemia (HP:0001915)5.37457028
3T lymphocytopenia (HP:0005403)5.13356091
4Hypoproteinemia (HP:0003075)5.02554995
5Increased IgM level (HP:0003496)3.92086829
6Stomatitis (HP:0010280)3.75338317
7Autoimmune hemolytic anemia (HP:0001890)3.74749086
8IgG deficiency (HP:0004315)3.69282980
9Abnormality of midbrain morphology (HP:0002418)3.60325547
10Molar tooth sign on MRI (HP:0002419)3.60325547
11Mitochondrial inheritance (HP:0001427)3.59529612
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.58776795
13Severe combined immunodeficiency (HP:0004430)3.58038363
14Acute necrotizing encephalopathy (HP:0006965)3.56200350
153-Methylglutaconic aciduria (HP:0003535)3.55609347
16Abnormality of T cells (HP:0002843)3.55165178
17Chronic diarrhea (HP:0002028)3.42450879
18Abnormal mitochondria in muscle tissue (HP:0008316)3.33789492
19Hepatocellular necrosis (HP:0001404)3.24907630
20Abnormality of eosinophils (HP:0001879)3.18654862
21Stomach cancer (HP:0012126)3.10538019
22Congenital stationary night blindness (HP:0007642)3.06914427
23Pendular nystagmus (HP:0012043)3.06444766
24Thyroiditis (HP:0100646)3.03924940
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03911891
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03911891
27Acute encephalopathy (HP:0006846)3.00947142
28Increased CSF lactate (HP:0002490)2.98021630
29Increased intramyocellular lipid droplets (HP:0012240)2.96261266
30Autoimmune thrombocytopenia (HP:0001973)2.94568803
31Abnormality of B cell number (HP:0010975)2.93703808
32Progressive macrocephaly (HP:0004481)2.89283247
33Hypoalbuminemia (HP:0003073)2.84003009
34Abnormal albumin level (HP:0012116)2.84003009
35Pancreatic cysts (HP:0001737)2.78419916
36Hepatic necrosis (HP:0002605)2.75482427
37Severe visual impairment (HP:0001141)2.70267294
38Eosinophilia (HP:0001880)2.68169418
39Combined immunodeficiency (HP:0005387)2.59417331
40Increased hepatocellular lipid droplets (HP:0006565)2.59034731
41Colon cancer (HP:0003003)2.56575363
42Leukocytosis (HP:0001974)2.51715545
43Abnormality of the renal cortex (HP:0011035)2.48496423
44Renal cortical cysts (HP:0000803)2.46430546
45Cerebral edema (HP:0002181)2.41939149
46Increased muscle lipid content (HP:0009058)2.40645585
47Pancreatic fibrosis (HP:0100732)2.37918322
48Optic disc pallor (HP:0000543)2.32051210
49Constricted visual fields (HP:0001133)2.30455791
50Lipid accumulation in hepatocytes (HP:0006561)2.30233571
51Attenuation of retinal blood vessels (HP:0007843)2.29567926
52Pancytopenia (HP:0001876)2.25957431
53Renal Fanconi syndrome (HP:0001994)2.20535778
54Abolished electroretinogram (ERG) (HP:0000550)2.15547702
55Abnormality of the prostate (HP:0008775)2.14809155
56Recurrent cutaneous fungal infections (HP:0011370)2.13600374
57Chronic mucocutaneous candidiasis (HP:0002728)2.13600374
58Abnormality of macular pigmentation (HP:0008002)2.11573745
59Nephronophthisis (HP:0000090)2.09804520
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07793267
61Hypothermia (HP:0002045)2.07017003
62Lactic acidosis (HP:0003128)2.06277905
63Oral leukoplakia (HP:0002745)2.05204589
64Bile duct proliferation (HP:0001408)2.04126012
65Abnormal biliary tract physiology (HP:0012439)2.04126012
66Abnormality of T cell physiology (HP:0011840)2.03680074
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03275362
68Abnormal rod and cone electroretinograms (HP:0008323)2.01910905
69Granulocytopenia (HP:0001913)2.00248621
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98040667
71Optic nerve coloboma (HP:0000588)1.96485385
72Encephalitis (HP:0002383)1.96370217
73Abnormality of the renal medulla (HP:0100957)1.96288884
74Methylmalonic aciduria (HP:0012120)1.96051685
75Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95312296
76Elevated erythrocyte sedimentation rate (HP:0003565)1.92288585
77Increased serum lactate (HP:0002151)1.92181086
78Respiratory failure (HP:0002878)1.91998866
79Impaired proprioception (HP:0010831)1.90619498
80Panhypogammaglobulinemia (HP:0003139)1.90237883
81Methylmalonic acidemia (HP:0002912)1.90175322
82True hermaphroditism (HP:0010459)1.88255343
83Recurrent fungal infections (HP:0002841)1.85104027
84Recurrent bronchitis (HP:0002837)1.84097798
85Generalized aminoaciduria (HP:0002909)1.83830143
86Rectal fistula (HP:0100590)1.83042695
87Rectovaginal fistula (HP:0000143)1.83042695
88Pustule (HP:0200039)1.79817196
89Abnormality of cells of the lymphoid lineage (HP:0012140)1.79574216
90Bronchitis (HP:0012387)1.75967196
91Meningitis (HP:0001287)1.75583930
92Lymphoma (HP:0002665)1.73208129
93Hypoplasia of the thymus (HP:0000778)1.72989519
94Amyotrophic lateral sclerosis (HP:0007354)1.71963610
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68709632
96Hemiplegia (HP:0002301)1.68189857
97Obstructive lung disease (HP:0006536)1.67306420
98Chronic obstructive pulmonary disease (HP:0006510)1.67306420
99Atrophy/Degeneration involving motor neurons (HP:0007373)1.66232254
100Chronic bronchitis (HP:0004469)1.64140866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.86851867
2KDR4.85762001
3MAP3K123.74494555
4TESK23.32708095
5FRK2.85352543
6ITK2.44860355
7MAP4K22.44342895
8PIK3CA2.43477053
9VRK22.34218983
10ADRBK22.24846745
11BUB12.03756122
12ZAK1.96080712
13NUAK11.93070169
14BCKDK1.79230037
15BMPR1B1.77865198
16PINK11.77367554
17MAP3K111.74382307
18GRK11.73748597
19MST41.65724986
20PASK1.62785876
21LIMK11.59043856
22SRPK11.54677748
23DYRK21.45619263
24PIM21.43929913
25DAPK21.37405929
26VRK11.34399014
27MAP4K11.27615775
28GRK51.27542941
29NME11.27110416
30STK161.24794056
31PRKCQ1.22855849
32TLK11.19177947
33WNK41.18245402
34DAPK11.16739353
35MAP2K61.12259602
36CSNK1G21.11865486
37SYK1.07899007
38GRK71.07690134
39CAMKK21.06870486
40TEC1.00776831
41CSNK1G30.99599676
42MARK10.98249142
43LCK0.98154625
44TESK10.97591720
45MAPKAPK30.91501588
46ZAP700.86753255
47BTK0.84539991
48CSNK1A1L0.84247309
49FES0.84115120
50CAMKK10.83230961
51JAK30.79501829
52INSRR0.77833353
53IKBKB0.76536254
54MAPK130.75430038
55TAOK30.75013889
56CSK0.74957872
57MYLK0.72189509
58WNK30.71105673
59CSNK1G10.68689565
60MAP2K70.68052586
61BLK0.66283226
62PIK3CG0.63267680
63GRK60.61569668
64CDK190.56120869
65PKN10.54727533
66ROCK10.54664457
67NEK60.54237914
68SCYL20.53287180
69YES10.51747660
70ILK0.50303950
71LYN0.49246712
72MATK0.44478603
73DAPK30.43804495
74TRIM280.42062236
75EIF2AK30.41411852
76TIE10.41269854
77PRKCA0.40499862
78OXSR10.40336125
79PIM10.40229492
80RPS6KA50.39937082
81CAMK2A0.39470055
82FYN0.39273835
83MINK10.37276074
84OBSCN0.36084655
85PAK30.35233980
86AURKA0.35017190
87PRKACA0.34627349
88EPHA30.34514199
89CSNK1A10.34334803
90MAP3K40.34157802
91PRKCE0.34102407
92ATR0.33863706
93IGF1R0.33539029
94BCR0.32874793
95TGFBR10.32337597
96CAMK2D0.31723823
97PLK40.31212621
98MUSK0.30783783
99ADRBK10.28158978
100TAOK10.26460389

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.87246413
2Proteasome_Homo sapiens_hsa030504.00561749
3Oxidative phosphorylation_Homo sapiens_hsa001903.39166415
4Graft-versus-host disease_Homo sapiens_hsa053322.98152109
5Autoimmune thyroid disease_Homo sapiens_hsa053202.82855550
6Parkinsons disease_Homo sapiens_hsa050122.73692514
7Allograft rejection_Homo sapiens_hsa053302.71035382
8Antigen processing and presentation_Homo sapiens_hsa046122.62732264
9Hematopoietic cell lineage_Homo sapiens_hsa046402.54219308
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36418510
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27939663
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.24809622
13RNA polymerase_Homo sapiens_hsa030202.23090462
14Protein export_Homo sapiens_hsa030602.20883596
15Type I diabetes mellitus_Homo sapiens_hsa049402.06094271
16Rheumatoid arthritis_Homo sapiens_hsa053231.82465898
17T cell receptor signaling pathway_Homo sapiens_hsa046601.80713602
18Alzheimers disease_Homo sapiens_hsa050101.73214985
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67101737
20Nitrogen metabolism_Homo sapiens_hsa009101.62214278
21Huntingtons disease_Homo sapiens_hsa050161.61413805
22Cardiac muscle contraction_Homo sapiens_hsa042601.52216615
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44516176
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36828854
25Butanoate metabolism_Homo sapiens_hsa006501.20075880
26Caffeine metabolism_Homo sapiens_hsa002321.17506797
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17026606
28Asthma_Homo sapiens_hsa053101.16929750
29Salmonella infection_Homo sapiens_hsa051321.15600599
30Phototransduction_Homo sapiens_hsa047441.15199671
31Ribosome_Homo sapiens_hsa030101.14662272
32Homologous recombination_Homo sapiens_hsa034401.13906254
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13470365
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.09120821
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08284290
36Linoleic acid metabolism_Homo sapiens_hsa005911.05549803
37Measles_Homo sapiens_hsa051621.00083876
38Fanconi anemia pathway_Homo sapiens_hsa034600.97902147
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96885948
40One carbon pool by folate_Homo sapiens_hsa006700.96109083
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94179472
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91891418
43Propanoate metabolism_Homo sapiens_hsa006400.91717259
44RNA degradation_Homo sapiens_hsa030180.91136897
45Base excision repair_Homo sapiens_hsa034100.90753425
46Peroxisome_Homo sapiens_hsa041460.90419020
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.89692329
48Pyrimidine metabolism_Homo sapiens_hsa002400.87803156
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85821536
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83589934
51DNA replication_Homo sapiens_hsa030300.80541430
52Collecting duct acid secretion_Homo sapiens_hsa049660.80459552
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75922174
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75739225
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69790391
56Viral myocarditis_Homo sapiens_hsa054160.68101376
57Purine metabolism_Homo sapiens_hsa002300.67189968
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.65406612
59Steroid biosynthesis_Homo sapiens_hsa001000.65256902
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.62232884
61Arachidonic acid metabolism_Homo sapiens_hsa005900.62016093
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61907817
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60679115
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.59319955
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56188892
66Retinol metabolism_Homo sapiens_hsa008300.54552783
67Sulfur metabolism_Homo sapiens_hsa009200.53875673
68Fatty acid elongation_Homo sapiens_hsa000620.53764788
69Systemic lupus erythematosus_Homo sapiens_hsa053220.52919491
70N-Glycan biosynthesis_Homo sapiens_hsa005100.51490707
71Chemokine signaling pathway_Homo sapiens_hsa040620.50162692
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49401326
73Metabolic pathways_Homo sapiens_hsa011000.45570159
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44774031
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40264437
76Ether lipid metabolism_Homo sapiens_hsa005650.39895735
77Apoptosis_Homo sapiens_hsa042100.37602582
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36274597
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.35612756
80Mismatch repair_Homo sapiens_hsa034300.34574517
81Shigellosis_Homo sapiens_hsa051310.34098823
82Morphine addiction_Homo sapiens_hsa050320.34091365
83Chemical carcinogenesis_Homo sapiens_hsa052040.33943415
84Nucleotide excision repair_Homo sapiens_hsa034200.33785913
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33222717
86Tryptophan metabolism_Homo sapiens_hsa003800.31990914
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30166964
88Epstein-Barr virus infection_Homo sapiens_hsa051690.27920732
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27899147
90Nicotine addiction_Homo sapiens_hsa050330.27746072
91Non-homologous end-joining_Homo sapiens_hsa034500.27238534
92Taste transduction_Homo sapiens_hsa047420.27139095
93Basal transcription factors_Homo sapiens_hsa030220.27085902
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26803155
95p53 signaling pathway_Homo sapiens_hsa041150.26560257
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25330687
97Herpes simplex infection_Homo sapiens_hsa051680.24236609
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22535145
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22356259
100RNA transport_Homo sapiens_hsa030130.20573650

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