NDUFB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.69710600
2ATP synthesis coupled proton transport (GO:0015986)9.04030667
3energy coupled proton transport, down electrochemical gradient (GO:0015985)9.04030667
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.11676492
5* respiratory electron transport chain (GO:0022904)7.82945624
6* electron transport chain (GO:0022900)7.63602162
7ribosomal small subunit biogenesis (GO:0042274)6.02875123
8oxidative phosphorylation (GO:0006119)5.76513162
9tricarboxylic acid cycle (GO:0006099)5.55091827
10viral transcription (GO:0019083)5.49429438
11ATP biosynthetic process (GO:0006754)5.35668407
12translational termination (GO:0006415)5.32122707
13ribosomal small subunit assembly (GO:0000028)5.25144958
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.11195303
15cotranslational protein targeting to membrane (GO:0006613)5.05399992
16protein targeting to ER (GO:0045047)5.02767641
17ribosomal large subunit biogenesis (GO:0042273)4.93794937
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.84144365
19maturation of SSU-rRNA (GO:0030490)4.81329457
20inner mitochondrial membrane organization (GO:0007007)4.81144555
21protein localization to endoplasmic reticulum (GO:0070972)4.80873494
22translational elongation (GO:0006414)4.70504668
23NADH metabolic process (GO:0006734)4.65181437
24purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.64293405
25purine nucleoside triphosphate biosynthetic process (GO:0009145)4.62547125
26hydrogen ion transmembrane transport (GO:1902600)4.51623080
27proteasome assembly (GO:0043248)4.48023918
28cellular ketone body metabolic process (GO:0046950)4.46457091
29protein complex biogenesis (GO:0070271)4.46374830
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.44636101
31NADH dehydrogenase complex assembly (GO:0010257)4.44636101
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.44636101
33translation (GO:0006412)4.41787631
34translational initiation (GO:0006413)4.36599939
35succinate metabolic process (GO:0006105)4.29340744
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.26425210
37viral life cycle (GO:0019058)4.24023498
38chaperone-mediated protein transport (GO:0072321)4.21055267
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.15973908
40mitochondrial respiratory chain complex assembly (GO:0033108)4.14906987
41ribonucleoprotein complex biogenesis (GO:0022613)4.13009292
42cellular protein complex disassembly (GO:0043624)4.12354164
43ribonucleoside triphosphate biosynthetic process (GO:0009201)4.07412430
44cellular component biogenesis (GO:0044085)4.02315443
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.98814786
46termination of RNA polymerase III transcription (GO:0006386)3.98814786
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.96407499
48ketone body metabolic process (GO:1902224)3.95275088
49proton transport (GO:0015992)3.93177885
50regulation of cellular amino acid metabolic process (GO:0006521)3.91733309
51negative regulation of ligase activity (GO:0051352)3.91322371
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.91322371
53rRNA modification (GO:0000154)3.89163756
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.88779991
55hydrogen transport (GO:0006818)3.88639465
56aerobic respiration (GO:0009060)3.88619053
57regulation of oxidative phosphorylation (GO:0002082)3.81169020
58anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.76711767
59regulation of acyl-CoA biosynthetic process (GO:0050812)3.75364618
60sarcomere organization (GO:0045214)3.73185445
61regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.67796181
62pseudouridine synthesis (GO:0001522)3.66618647
63establishment of protein localization to mitochondrial membrane (GO:0090151)3.65696415
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.60337251
65transcription from mitochondrial promoter (GO:0006390)3.56074752
66rRNA processing (GO:0006364)3.54521438
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54306281
68signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54306281
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.53364522
70formation of translation preinitiation complex (GO:0001731)3.53246749
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.52676600
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.52676600
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.52676600
74branched-chain amino acid catabolic process (GO:0009083)3.52670512
75nucleoside triphosphate biosynthetic process (GO:0009142)3.50802377
76actin-myosin filament sliding (GO:0033275)3.50797394
77muscle filament sliding (GO:0030049)3.50797394
78oxaloacetate metabolic process (GO:0006107)3.50626056
79protein complex disassembly (GO:0043241)3.48961753
80positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.48104401
81protein targeting to membrane (GO:0006612)3.46208380
82regulation of cofactor metabolic process (GO:0051193)3.45990006
83regulation of coenzyme metabolic process (GO:0051196)3.45990006
84signal transduction involved in DNA damage checkpoint (GO:0072422)3.45501891
85signal transduction involved in DNA integrity checkpoint (GO:0072401)3.45501891
86mitochondrial transport (GO:0006839)3.41163573
87ubiquinone biosynthetic process (GO:0006744)3.40266403
88quinone biosynthetic process (GO:1901663)3.40266403
89purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.39766344
90purine nucleoside monophosphate biosynthetic process (GO:0009127)3.39766344
91signal transduction involved in cell cycle checkpoint (GO:0072395)3.38343588
92rRNA metabolic process (GO:0016072)3.38332710
93positive regulation of ligase activity (GO:0051351)3.37142837
94macromolecular complex disassembly (GO:0032984)3.36729008
95aspartate family amino acid catabolic process (GO:0009068)3.34268919
96lysine metabolic process (GO:0006553)3.34091718
97lysine catabolic process (GO:0006554)3.34091718
98regulation of mitochondrial translation (GO:0070129)3.30077420
99short-chain fatty acid metabolic process (GO:0046459)3.29608457
100erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28265689
101L-phenylalanine catabolic process (GO:0006559)3.28265689
102fatty acid beta-oxidation (GO:0006635)3.27530403
103carnitine shuttle (GO:0006853)3.26609506
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26597896
105L-phenylalanine metabolic process (GO:0006558)3.26381050
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26381050
107* generation of precursor metabolites and energy (GO:0006091)3.25485724
108ribosome biogenesis (GO:0042254)3.23988359
109DNA replication checkpoint (GO:0000076)3.16425531
110regulation of ubiquitin-protein transferase activity (GO:0051438)3.15569116
111cellular respiration (GO:0045333)3.15015563
112establishment of integrated proviral latency (GO:0075713)3.14550282
113spliceosomal snRNP assembly (GO:0000387)3.14207962
1142-oxoglutarate metabolic process (GO:0006103)3.13548497
115acetyl-CoA metabolic process (GO:0006084)3.10350940
116regulation of cellular respiration (GO:0043457)3.10329583
117fatty acid catabolic process (GO:0009062)3.08745941
118nuclear-transcribed mRNA catabolic process (GO:0000956)3.08727165
119heart contraction (GO:0060047)3.07729899
120heart process (GO:0003015)3.07729899
121telomere maintenance via semi-conservative replication (GO:0032201)3.07211548
122nucleoside monophosphate biosynthetic process (GO:0009124)3.06354171
123ubiquinone metabolic process (GO:0006743)3.05472949
124regulation of ligase activity (GO:0051340)3.03539244
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03232780
126regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.02963683
127regulation of cellular amine metabolic process (GO:0033238)3.01861129
128glyoxylate metabolic process (GO:0046487)3.01506748
129branched-chain amino acid metabolic process (GO:0009081)3.01065810
130fatty acid transmembrane transport (GO:1902001)3.00399976
131cullin deneddylation (GO:0010388)2.99642401
132DNA strand elongation involved in DNA replication (GO:0006271)2.98270704
133nucleobase-containing small molecule interconversion (GO:0015949)2.97598143
134regulation of relaxation of muscle (GO:1901077)2.97331768
135purine nucleoside biosynthetic process (GO:0042451)2.97173660
136purine ribonucleoside biosynthetic process (GO:0046129)2.97173660
137fatty acid oxidation (GO:0019395)2.96152545
138lipid oxidation (GO:0034440)2.89898465
139regulation of cell communication by electrical coupling (GO:0010649)2.85265466
140cardiac myofibril assembly (GO:0055003)2.84834251
141cardiac muscle contraction (GO:0060048)2.83163526
142regulation of sequestering of triglyceride (GO:0010889)2.81281584
143protein neddylation (GO:0045116)2.80698281
144regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.80064430
145actin-mediated cell contraction (GO:0070252)2.78992027
146negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.76115618
147monocarboxylic acid catabolic process (GO:0072329)2.75984827
148negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.74932601
149ribonucleoside monophosphate biosynthetic process (GO:0009156)2.74078319
150protein targeting to mitochondrion (GO:0006626)2.70360071
151myofibril assembly (GO:0030239)2.69288989
152regulation of sulfur metabolic process (GO:0042762)2.68558560
153regulation of skeletal muscle contraction (GO:0014819)2.66886102
154aldehyde catabolic process (GO:0046185)2.65491087
155regulation of actin filament-based movement (GO:1903115)2.64650585
156protein localization to mitochondrion (GO:0070585)2.64185757
157establishment of protein localization to mitochondrion (GO:0072655)2.63458571
158regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63421423
159protein-cofactor linkage (GO:0018065)2.63225185
160acyl-CoA metabolic process (GO:0006637)2.63202367
161thioester metabolic process (GO:0035383)2.63202367
162cytochrome complex assembly (GO:0017004)2.59423811
163regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.59153792
164respiratory chain complex IV assembly (GO:0008535)2.58320176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.06231752
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.51061318
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.33103271
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.71940227
5E2F7_22180533_ChIP-Seq_HELA_Human3.54942001
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12552398
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89990550
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83671153
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77423048
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.75222673
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.60224475
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46852307
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.44227922
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.42602245
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37952197
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36275588
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.35423235
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34518973
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31032439
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27245134
21FOXP3_21729870_ChIP-Seq_TREG_Human2.25551729
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.24751022
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24718742
24ELK1_19687146_ChIP-ChIP_HELA_Human2.17427742
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16955419
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13572772
27TTF2_22483619_ChIP-Seq_HELA_Human2.13132418
28GABP_19822575_ChIP-Seq_HepG2_Human2.12487996
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.12424950
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.11088589
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.06582983
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04646832
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01585422
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.97048838
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95818200
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91975398
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87436438
38* LXR_22158963_ChIP-Seq_LIVER_Mouse1.82076778
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79740292
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76390033
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71633479
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68758322
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63408895
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63150202
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.60672141
46VDR_22108803_ChIP-Seq_LS180_Human1.59826553
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59600045
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57531716
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55198824
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53515684
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52376732
52KDM5A_27292631_Chip-Seq_BREAST_Human1.50841110
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47539778
54EZH2_22144423_ChIP-Seq_EOC_Human1.43932646
55PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43106950
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39267379
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37349570
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37141492
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.36732339
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36610235
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36300745
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.34477535
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34397090
64AR_21909140_ChIP-Seq_LNCAP_Human1.33380401
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33172818
66HTT_18923047_ChIP-ChIP_STHdh_Human1.33141842
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32701229
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30818620
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29004008
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28191219
71* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27363612
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24431208
73CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23990810
74* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23121187
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22062688
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18985975
77MYC_18555785_ChIP-Seq_MESCs_Mouse1.18473156
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17311805
79MYC_18940864_ChIP-ChIP_HL60_Human1.17016494
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15407792
81ZNF263_19887448_ChIP-Seq_K562_Human1.14902654
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14220873
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.14211461
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13993835
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12692345
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10940890
87DCP1A_22483619_ChIP-Seq_HELA_Human1.08990952
88RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04987899
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04853688
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04409736
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04182327
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04148509
93TFEB_21752829_ChIP-Seq_HELA_Human1.03164719
94* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00939338
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00229370
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99634174
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97100240
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97086080
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96779328
100NANOG_20526341_ChIP-Seq_ESCs_Human0.96149869
101ERG_20517297_ChIP-Seq_VCAP_Human0.95585702
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94870194
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93462550
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92363611
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92239576
106FOXP1_21924763_ChIP-Seq_HESCs_Human0.90746306
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90665070
108* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90411845
109YY1_22570637_ChIP-Seq_MALME-3M_Human0.90317432
110ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90106644
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89920783
112TAF2_19829295_ChIP-Seq_ESCs_Human0.88833009
113TAF15_26573619_Chip-Seq_HEK293_Human0.88549717
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.88177203
115ERG_21242973_ChIP-ChIP_JURKAT_Human0.87058249
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85927630
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84473787
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84221254
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83458403
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.82669797
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81994695
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80575143
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.79875342
124ELF5_23300383_ChIP-Seq_T47D_Human0.79216133
125JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79191225
126OCT4_20526341_ChIP-Seq_ESCs_Human0.78469683
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77676648
128SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77369946
129CTCF_20526341_ChIP-Seq_ESCs_Human0.77345248
130SOX17_20123909_ChIP-Seq_XEN_Mouse0.77295311
131EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77103530
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76720233
133SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76490383
134EZH2_27304074_Chip-Seq_ESCs_Mouse0.76085136
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75797954
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75606849
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74526296
138CTCF_27219007_Chip-Seq_Bcells_Human0.74285652
139MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.73339320
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73104109
141MYC_19829295_ChIP-Seq_ESCs_Human0.73025270
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.71993070
143CIITA_25753668_ChIP-Seq_RAJI_Human0.71922406
144VDR_23849224_ChIP-Seq_CD4+_Human0.71815850
145ZNF274_21170338_ChIP-Seq_K562_Hela0.71787576
146SOX2_22085726_ChIP-Seq_NPCs_Mouse0.71312369
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71116463
148* NCOR_22424771_ChIP-Seq_293T_Human0.70681876
149CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70332925
150PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70246694
151CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.69397193
152STAT1_20625510_ChIP-Seq_HELA_Human0.69240977
153THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69042019
154OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68626302
155XRN2_22483619_ChIP-Seq_HELA_Human0.68046329
156* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.68028510
157SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67982582
158TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.67234424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.45377528
2MP0003646_muscle_fatigue4.18499578
3MP0000751_myopathy3.40044088
4MP0003806_abnormal_nucleotide_metabolis3.37056361
5MP0003693_abnormal_embryo_hatching3.28763590
6MP0006036_abnormal_mitochondrial_physio3.18189733
7MP0004957_abnormal_blastocyst_morpholog3.15642470
8MP0004215_abnormal_myocardial_fiber3.11904666
9MP0008058_abnormal_DNA_repair3.09853124
10MP0000749_muscle_degeneration3.08184080
11MP0005360_urolithiasis3.01407958
12MP0004084_abnormal_cardiac_muscle2.98844428
13MP0004036_abnormal_muscle_relaxation2.88743496
14MP0002139_abnormal_hepatobiliary_system2.86580741
15MP0010094_abnormal_chromosome_stability2.69851275
16MP0005085_abnormal_gallbladder_physiolo2.69463694
17MP0005330_cardiomyopathy2.51746727
18MP0003111_abnormal_nucleus_morphology2.45417030
19MP0003718_maternal_effect2.38987609
20MP0000372_irregular_coat_pigmentation2.36956278
21MP0008875_abnormal_xenobiotic_pharmacok2.33492726
22MP0003077_abnormal_cell_cycle2.32166410
23MP0001529_abnormal_vocalization2.29693617
24MP0003786_premature_aging2.25304051
25MP0005365_abnormal_bile_salt2.19190738
26MP0006035_abnormal_mitochondrial_morpho2.17005405
27MP0008932_abnormal_embryonic_tissue2.15178094
28MP0004043_abnormal_pH_regulation2.08169827
29MP0003123_paternal_imprinting2.01331051
30MP0003137_abnormal_impulse_conducting2.00564254
31MP0008007_abnormal_cellular_replicative1.98981987
32MP0004130_abnormal_muscle_cell1.97852114
33MP0005332_abnormal_amino_acid1.95362269
34MP0002972_abnormal_cardiac_muscle1.94304345
35MP0003195_calcinosis1.93033894
36MP0003941_abnormal_skin_development1.88505718
37MP0005083_abnormal_biliary_tract1.86676667
38MP0009697_abnormal_copulation1.85236786
39MP0002822_catalepsy1.84617263
40MP0005620_abnormal_muscle_contractility1.82444745
41MP0004145_abnormal_muscle_electrophysio1.79680489
42MP0004484_altered_response_of1.79090123
43MP0003186_abnormal_redox_activity1.70935549
44MP0008775_abnormal_heart_ventricle1.70825468
45MP0005408_hypopigmentation1.69914911
46MP0004087_abnormal_muscle_fiber1.66914043
47MP0003880_abnormal_central_pattern1.63849884
48MP0006292_abnormal_olfactory_placode1.57224909
49MP0002106_abnormal_muscle_physiology1.55720840
50MP0005385_cardiovascular_system_phenoty1.54475432
51MP0001544_abnormal_cardiovascular_syste1.54475432
52MP0005451_abnormal_body_composition1.54398105
53MP0002938_white_spotting1.52237453
54MP0000747_muscle_weakness1.50958487
55MP0002269_muscular_atrophy1.49434436
56MP0004085_abnormal_heartbeat1.47059059
57MP0000750_abnormal_muscle_regeneration1.46737207
58MP0001905_abnormal_dopamine_level1.42801037
59MP0001666_abnormal_nutrient_absorption1.40869384
60MP0004147_increased_porphyrin_level1.39990686
61MP0006276_abnormal_autonomic_nervous1.39932367
62MP0008995_early_reproductive_senescence1.38877525
63MP0009379_abnormal_foot_pigmentation1.37835922
64MP0002332_abnormal_exercise_endurance1.33621412
65MP0006138_congestive_heart_failure1.31709643
66MP0000358_abnormal_cell_content/1.31607261
67MP0005266_abnormal_metabolism1.31328612
68MP0005584_abnormal_enzyme/coenzyme_acti1.28617227
69MP0005369_muscle_phenotype1.25891252
70MP0005535_abnormal_body_temperature1.25873870
71MP0005636_abnormal_mineral_homeostasis1.23643949
72MP0000759_abnormal_skeletal_muscle1.22696631
73MP0005670_abnormal_white_adipose1.21848441
74MP0002160_abnormal_reproductive_system1.16101157
75MP0005666_abnormal_adipose_tissue1.14402824
76MP0010329_abnormal_lipoprotein_level1.14204117
77MP0000230_abnormal_systemic_arterial1.14043070
78MP0003221_abnormal_cardiomyocyte_apopto1.13998771
79MP0002118_abnormal_lipid_homeostasis1.11503313
80MP0004142_abnormal_muscle_tone1.08245186
81MP0008877_abnormal_DNA_methylation1.07681121
82MP0003656_abnormal_erythrocyte_physiolo1.05987712
83MP0005646_abnormal_pituitary_gland1.05811984
84MP0005319_abnormal_enzyme/_coenzyme1.04302051
85MP0002090_abnormal_vision1.04213644
86MP0001661_extended_life_span1.03683390
87MP0000013_abnormal_adipose_tissue1.03657111
88MP0002736_abnormal_nociception_after1.02658364
89MP0009643_abnormal_urine_homeostasis1.02258115
90MP0001730_embryonic_growth_arrest1.02042388
91MP0001764_abnormal_homeostasis1.02032632
92MP0006072_abnormal_retinal_apoptosis1.00951002
93MP0002876_abnormal_thyroid_physiology0.99301194
94MP0010630_abnormal_cardiac_muscle0.98981844
95MP0005084_abnormal_gallbladder_morpholo0.97871508
96MP0002163_abnormal_gland_morphology0.97348867
97MP0002272_abnormal_nervous_system0.96548125
98MP0008789_abnormal_olfactory_epithelium0.94699356
99MP0005165_increased_susceptibility_to0.94414634
100MP0005386_behavior/neurological_phenoty0.93099724
101MP0004924_abnormal_behavior0.93099724
102MP0002210_abnormal_sex_determination0.92795089
103MP0000350_abnormal_cell_proliferation0.92345293
104MP0001697_abnormal_embryo_size0.92108568
105MP0001853_heart_inflammation0.91063210
106MP0001440_abnormal_grooming_behavior0.91007803
107MP0005376_homeostasis/metabolism_phenot0.86951950
108MP0002127_abnormal_cardiovascular_syste0.85835622
109MP0009745_abnormal_behavioral_response0.85085692
110MP0004233_abnormal_muscle_weight0.84571617
111MP0001881_abnormal_mammary_gland0.84382107
112MP0005379_endocrine/exocrine_gland_phen0.83635492
113MP0001929_abnormal_gametogenesis0.83081606
114MP0001968_abnormal_touch/_nociception0.82902396
115MP0003011_delayed_dark_adaptation0.82096419
116MP0002078_abnormal_glucose_homeostasis0.81817174
117MP0000313_abnormal_cell_death0.81082930
118MP0001727_abnormal_embryo_implantation0.79245002
119MP0008872_abnormal_physiological_respon0.79188409
120MP0003329_amyloid_beta_deposits0.78381792
121MP0005075_abnormal_melanosome_morpholog0.77660642
122MP0010030_abnormal_orbit_morphology0.77351261
123MP0001485_abnormal_pinna_reflex0.76150365
124MP0004019_abnormal_vitamin_homeostasis0.76053791
125MP0002080_prenatal_lethality0.74973965
126MP0002064_seizures0.73828486
127MP0001145_abnormal_male_reproductive0.72240919
128MP0001756_abnormal_urination0.71753264
129MP0004270_analgesia0.71495133
130MP0009840_abnormal_foam_cell0.71485326
131MP0005645_abnormal_hypothalamus_physiol0.71070715
132MP0002971_abnormal_brown_adipose0.71044833
133MP0001664_abnormal_digestion0.70677918
134MP0001984_abnormal_olfaction0.70016926
135MP0002132_abnormal_respiratory_system0.69403066
136MP0005389_reproductive_system_phenotype0.69263486
137MP0001765_abnormal_ion_homeostasis0.68945570
138MP0000653_abnormal_sex_gland0.68831009
139MP0002734_abnormal_mechanical_nocicepti0.67918412
140MP0002638_abnormal_pupillary_reflex0.67162649
141MP0005410_abnormal_fertilization0.66253968
142MP0005448_abnormal_energy_balance0.65619268
143MP0009046_muscle_twitch0.64374096
144MP0008057_abnormal_DNA_replication0.64094643
145MP0000343_altered_response_to0.64036321
146MP0002095_abnormal_skin_pigmentation0.63925691
147MP0003868_abnormal_feces_composition0.63689929
148MP0000678_abnormal_parathyroid_gland0.63367151
149MP0003252_abnormal_bile_duct0.63036970
150MP0002735_abnormal_chemical_nociception0.62704394
151MP0001188_hyperpigmentation0.61333345
152MP0005501_abnormal_skin_physiology0.59994191
153MP0001919_abnormal_reproductive_system0.54065471

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)6.66259262
2* Abnormal mitochondria in muscle tissue (HP:0008316)6.32748863
3* Acute encephalopathy (HP:0006846)5.89483565
4* Mitochondrial inheritance (HP:0001427)5.64397779
5* Progressive macrocephaly (HP:0004481)5.48774271
6Hepatic necrosis (HP:0002605)5.37521572
7Hepatocellular necrosis (HP:0001404)5.30896179
8* Increased CSF lactate (HP:0002490)5.08883689
9* Cerebral edema (HP:0002181)4.80369969
10Increased intramyocellular lipid droplets (HP:0012240)4.07694761
11Increased muscle lipid content (HP:0009058)4.05646204
12Lipid accumulation in hepatocytes (HP:0006561)4.05033758
13* Lactic acidosis (HP:0003128)4.02065585
14Abnormality of glycolysis (HP:0004366)3.97826581
15Increased serum pyruvate (HP:0003542)3.97826581
16Increased hepatocellular lipid droplets (HP:0006565)3.95492167
17Sudden death (HP:0001699)3.91565596
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.74762775
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.74762775
20* Respiratory failure (HP:0002878)3.74138728
21Abnormal number of erythroid precursors (HP:0012131)3.73142055
22* Exercise intolerance (HP:0003546)3.67784614
23Macrocytic anemia (HP:0001972)3.55976343
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.55733525
25Calf muscle hypertrophy (HP:0008981)3.54451505
26Myoglobinuria (HP:0002913)3.50056995
27Muscle hypertrophy of the lower extremities (HP:0008968)3.49093500
28Exercise-induced myalgia (HP:0003738)3.48430746
29Exercise-induced muscle cramps (HP:0003710)3.34154100
30Increased serum lactate (HP:0002151)3.33054951
31Palpitations (HP:0001962)3.31859478
32Abnormality of dicarboxylic acid metabolism (HP:0010995)3.31385298
33Dicarboxylic aciduria (HP:0003215)3.31385298
34Reticulocytopenia (HP:0001896)3.31177327
35Renal Fanconi syndrome (HP:0001994)3.28919879
36* Optic disc pallor (HP:0000543)3.23768636
37Type I transferrin isoform profile (HP:0003642)3.18575665
38Pheochromocytoma (HP:0002666)3.14388295
39Abnormality of fatty-acid metabolism (HP:0004359)3.08277055
40* Lethargy (HP:0001254)3.07162798
41* Leukodystrophy (HP:0002415)3.05925631
42Neuroendocrine neoplasm (HP:0100634)3.05263402
43Rhabdomyolysis (HP:0003201)3.02127796
44Ketoacidosis (HP:0001993)2.99989494
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.95725698
46Hypoglycemic coma (HP:0001325)2.91991500
47Ventricular tachycardia (HP:0004756)2.88878695
48Glycosuria (HP:0003076)2.80106976
49Abnormality of urine glucose concentration (HP:0011016)2.80106976
50Ketosis (HP:0001946)2.74012666
51Conjunctival hamartoma (HP:0100780)2.70945827
52Nemaline bodies (HP:0003798)2.70551209
53Generalized aminoaciduria (HP:0002909)2.69415878
54Muscle fiber inclusion bodies (HP:0100299)2.65357879
55CNS demyelination (HP:0007305)2.59237982
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.59036475
57Cerebral hypomyelination (HP:0006808)2.58321688
58Abnormality of methionine metabolism (HP:0010901)2.57086439
59Microvesicular hepatic steatosis (HP:0001414)2.55627074
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.55057910
61Abnormality of the calf musculature (HP:0001430)2.54992818
623-Methylglutaconic aciduria (HP:0003535)2.53967216
63Reduced antithrombin III activity (HP:0001976)2.52581654
64Methylmalonic aciduria (HP:0012120)2.51272200
65Lipoatrophy (HP:0100578)2.51227528
66* Vomiting (HP:0002013)2.48695628
67Muscle stiffness (HP:0003552)2.47178375
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.46186810
69Myotonia (HP:0002486)2.45615190
70Hyperammonemia (HP:0001987)2.45472340
71Aplastic anemia (HP:0001915)2.44697867
72Muscle fiber splitting (HP:0003555)2.44636862
73Abnormal protein glycosylation (HP:0012346)2.44071146
74Abnormal glycosylation (HP:0012345)2.44071146
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44071146
76Abnormal protein N-linked glycosylation (HP:0012347)2.44071146
77Metabolic acidosis (HP:0001942)2.42350153
78Respiratory difficulties (HP:0002880)2.42043464
79Pallor (HP:0000980)2.40777491
80Ragged-red muscle fibers (HP:0003200)2.39279545
81Exertional dyspnea (HP:0002875)2.38306289
82Hyperglycinuria (HP:0003108)2.35567402
83Atrial fibrillation (HP:0005110)2.30618574
84Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28844729
85Dilated cardiomyopathy (HP:0001644)2.28174669
86Syncope (HP:0001279)2.24816851
87Progressive muscle weakness (HP:0003323)2.23111427
88* X-linked dominant inheritance (HP:0001423)2.22735114
89Hyperphosphaturia (HP:0003109)2.21913878
90Supraventricular tachycardia (HP:0004755)2.19435809
91Abnormality of renal resorption (HP:0011038)2.19263555
92Proximal tubulopathy (HP:0000114)2.17446527
93Abnormality of serine family amino acid metabolism (HP:0010894)2.17128186
94Abnormality of glycine metabolism (HP:0010895)2.17128186
95Abnormality of serum amino acid levels (HP:0003112)2.16498602
96Primary atrial arrhythmia (HP:0001692)2.16341193
97Emotional lability (HP:0000712)2.16154425
98Supraventricular arrhythmia (HP:0005115)2.11349733
99Prolonged QT interval (HP:0001657)2.10444610
100Cholecystitis (HP:0001082)2.09873750
101Abnormal gallbladder physiology (HP:0012438)2.09873750
102Right ventricular cardiomyopathy (HP:0011663)2.09661275
103Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.09282302
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06783352
105Abnormality of alanine metabolism (HP:0010916)2.06783352
106Hyperalaninemia (HP:0003348)2.06783352
107Testicular atrophy (HP:0000029)2.05268450
108Cerebral hemorrhage (HP:0001342)2.02267799
109Myokymia (HP:0002411)2.01415539
110EMG: myopathic abnormalities (HP:0003458)2.00656311
111Methylmalonic acidemia (HP:0002912)1.99469761
112Abnormality of cells of the erythroid lineage (HP:0012130)1.98519900
113Multiple enchondromatosis (HP:0005701)1.97771914
114Hyperthyroidism (HP:0000836)1.97549724
115Pancytopenia (HP:0001876)1.96859835
116Nausea (HP:0002018)1.95785219
117Paralysis (HP:0003470)1.94707532
118Gout (HP:0001997)1.93725686
119Neoplasm of head and neck (HP:0012288)1.92090070
120Esophageal neoplasm (HP:0100751)1.92090070
121Hyporeflexia of lower limbs (HP:0002600)1.91945408
122Abnormality of the anterior horn cell (HP:0006802)1.90483759
123Degeneration of anterior horn cells (HP:0002398)1.90483759
124Cholelithiasis (HP:0001081)1.89133450
125Abnormal urine phosphate concentration (HP:0012599)1.86285332
126Hyperglycinemia (HP:0002154)1.86256626
127Neoplasm of the adrenal gland (HP:0100631)1.85735276
128Sparse eyelashes (HP:0000653)1.84172382
129Abnormality of placental membranes (HP:0011409)1.80567241
130Amniotic constriction ring (HP:0009775)1.80567241
131Abnormal gallbladder morphology (HP:0012437)1.80171664
132Oral leukoplakia (HP:0002745)1.76898888
133Poor suck (HP:0002033)1.75931193
134Progressive microcephaly (HP:0000253)1.71917187
135Megaloblastic anemia (HP:0001889)1.70759442
136Microretrognathia (HP:0000308)1.69035782
137Hypokinesia (HP:0002375)1.66918119
138Hyperinsulinemic hypoglycemia (HP:0000825)1.63751830
139CNS hypomyelination (HP:0003429)1.63057820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.58722156
2VRK24.40122003
3OBSCN3.90895431
4MYLK3.78509730
5NME13.57029230
6NME23.26171486
7PDK33.04037987
8PDK43.04037987
9CDC72.76167649
10PHKG22.69033949
11PHKG12.69033949
12MAP3K122.29204446
13PIK3CA2.26814653
14TTN2.20838006
15WNK42.19997549
16MUSK2.06871650
17STK162.01541882
18SRPK11.99615044
19LMTK21.98507473
20ARAF1.90887181
21NEK11.88317182
22PDK21.84141955
23PINK11.83336603
24GRK71.82124477
25STK391.81671530
26TTK1.70545431
27OXSR11.66776628
28EIF2AK31.56318652
29CAMK2D1.45446976
30MST1R1.33196790
31GRK51.32647250
32DAPK31.32139194
33PLK11.29375349
34WNK31.28780479
35PLK41.26490928
36TESK21.24638494
37CDK191.24164307
38BRSK11.17813693
39LIMK11.17589493
40AURKB1.14208295
41MAP2K41.14114037
42AURKA1.13715514
43PLK31.11596764
44ILK1.10396470
45TSSK61.08260793
46PBK1.07679948
47RPS6KB21.07095968
48CASK1.04727043
49MAP2K71.02768708
50CAMK2G1.01530797
51WEE10.96421441
52CAMK2A0.94780937
53CAMK2B0.92828608
54ABL20.91635005
55NUAK10.91526910
56BMPR1B0.89056773
57TIE10.88542939
58MAP3K40.86996377
59TRIM280.85610911
60CSNK2A20.85119769
61EPHA40.85018609
62PRKCI0.82990602
63SCYL20.82752218
64MAPKAPK50.82497856
65STK240.81808321
66PAK40.80669496
67MAP4K20.78892770
68PIK3CG0.78214744
69MAPK120.76790227
70INSRR0.75149105
71CSNK2A10.73798656
72STK40.71727145
73MST40.71558503
74ATR0.71370248
75BRAF0.71282569
76ADRBK20.70264763
77PRKACA0.69891965
78CSNK1G30.69633523
79KDR0.68702441
80CHEK10.67837676
81LRRK20.66923102
82STK38L0.66715685
83PAK10.65648132
84BRSK20.64873219
85TLK10.64268492
86MAP3K110.63436447
87VRK10.63343364
88EPHA20.63274666
89ADRBK10.62778820
90PTK2B0.61820553
91CSNK1E0.61791286
92CHEK20.60213858
93BCR0.59972248
94AKT20.58558294
95MAP3K70.58405372
96PIM20.57723587
97PKN10.56437063
98TAF10.56392556
99CSNK1G10.55854667
100ROCK20.55203706
101PAK30.55077421
102CAMK10.55070993
103PRKCE0.55008839
104RPS6KA50.54840784
105ZAK0.53176547
106TESK10.52442787
107CDK80.52420776
108CDK70.51608872
109ROCK10.48189157
110BUB10.48161250
111EIF2AK10.47557757
112MAP2K60.47383453
113PRKACG0.47146130
114CSNK1G20.46419392
115CLK10.46380741
116MAP2K10.46158515
117EIF2AK20.44491431
118PRKD10.42628912
119IRAK30.42555442
120PRKACB0.42396372
121UHMK10.42083812
122CAMKK20.41526789
123DYRK20.41091710
124MAP3K80.41085669
125GRK10.39921291
126PRKCG0.39610228
127PRKCA0.38305765
128PRKG20.37106171
129NTRK30.36652797
130PRKAA20.36475954
131MAPK40.35354737
132MINK10.33225600
133DAPK10.32935425
134TNIK0.32897385
135ATM0.32861036
136ALK0.32701042
137CDK140.32488474
138PKN20.32334623
139CDK10.32102408
140CDK180.31958545
141MAPKAPK30.31095553
142CDK150.30687525
143DMPK0.30354690
144CSNK1A10.30003823
145CCNB10.29878011
146PRKAA10.29630110
147ERBB40.29599001
148PLK20.29466069
149CDK11A0.29230985
150DAPK20.28803993
151CSNK1A1L0.26349928
152CDK20.25813467
153RAF10.24614980

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.27317984
2Parkinsons disease_Homo sapiens_hsa050124.67227717
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.83097727
4Alzheimers disease_Homo sapiens_hsa050103.51211529
5Huntingtons disease_Homo sapiens_hsa050163.08187272
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.07811292
7Cardiac muscle contraction_Homo sapiens_hsa042603.00617593
8Propanoate metabolism_Homo sapiens_hsa006402.71009285
9DNA replication_Homo sapiens_hsa030302.66294236
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.65466045
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49365567
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33875716
13Mismatch repair_Homo sapiens_hsa034302.31028265
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30691062
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16757135
16Pyruvate metabolism_Homo sapiens_hsa006202.15670691
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.10487328
18Sulfur metabolism_Homo sapiens_hsa009202.07259929
19Butanoate metabolism_Homo sapiens_hsa006502.02294453
20Homologous recombination_Homo sapiens_hsa034402.01689232
21Fatty acid degradation_Homo sapiens_hsa000712.01568443
22Ribosome_Homo sapiens_hsa030101.95737002
23Carbon metabolism_Homo sapiens_hsa012001.94741797
24Fatty acid elongation_Homo sapiens_hsa000621.87358823
25Spliceosome_Homo sapiens_hsa030401.68020838
26Proteasome_Homo sapiens_hsa030501.67151267
27One carbon pool by folate_Homo sapiens_hsa006701.66926070
28Nucleotide excision repair_Homo sapiens_hsa034201.65160272
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64587847
30Fatty acid metabolism_Homo sapiens_hsa012121.60743802
31Base excision repair_Homo sapiens_hsa034101.58546702
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54920703
33RNA transport_Homo sapiens_hsa030131.43321614
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39095911
35Peroxisome_Homo sapiens_hsa041461.32537078
36Tryptophan metabolism_Homo sapiens_hsa003801.27336809
37Phenylalanine metabolism_Homo sapiens_hsa003601.24255975
38Protein export_Homo sapiens_hsa030601.19070806
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16263077
40RNA degradation_Homo sapiens_hsa030181.15221892
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.14953950
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12341847
43beta-Alanine metabolism_Homo sapiens_hsa004101.12026728
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11581242
45Basal transcription factors_Homo sapiens_hsa030221.07359457
46Biosynthesis of amino acids_Homo sapiens_hsa012301.07229705
47Fanconi anemia pathway_Homo sapiens_hsa034601.06820675
48Tyrosine metabolism_Homo sapiens_hsa003501.06572307
49PPAR signaling pathway_Homo sapiens_hsa033201.05522332
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95711349
51Collecting duct acid secretion_Homo sapiens_hsa049660.94321790
52Chemical carcinogenesis_Homo sapiens_hsa052040.92672809
53Vitamin B6 metabolism_Homo sapiens_hsa007500.92228787
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92003063
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.90969464
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90762231
57* Metabolic pathways_Homo sapiens_hsa011000.90339739
58Fat digestion and absorption_Homo sapiens_hsa049750.89055316
59Arginine biosynthesis_Homo sapiens_hsa002200.88239021
60Glutathione metabolism_Homo sapiens_hsa004800.87838547
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84213340
62Arginine and proline metabolism_Homo sapiens_hsa003300.84125442
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81308496
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80426104
65Histidine metabolism_Homo sapiens_hsa003400.78815980
66Starch and sucrose metabolism_Homo sapiens_hsa005000.77989380
67Fructose and mannose metabolism_Homo sapiens_hsa000510.75661014
68Non-homologous end-joining_Homo sapiens_hsa034500.73822129
69Folate biosynthesis_Homo sapiens_hsa007900.73537569
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72266709
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69932349
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69112650
73Cell cycle_Homo sapiens_hsa041100.67169430
74Dilated cardiomyopathy_Homo sapiens_hsa054140.66246381
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.60296674
76Linoleic acid metabolism_Homo sapiens_hsa005910.58142356
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57949897
78Pentose phosphate pathway_Homo sapiens_hsa000300.56748714
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.56279939
80Sulfur relay system_Homo sapiens_hsa041220.53302681
81N-Glycan biosynthesis_Homo sapiens_hsa005100.52837616
82Galactose metabolism_Homo sapiens_hsa000520.52582236
83RNA polymerase_Homo sapiens_hsa030200.51300768
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51078141
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.49567444
86Vibrio cholerae infection_Homo sapiens_hsa051100.48434244
87Retinol metabolism_Homo sapiens_hsa008300.43804733
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43308227
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42120478
90Arachidonic acid metabolism_Homo sapiens_hsa005900.39396239
91Bile secretion_Homo sapiens_hsa049760.39117081
92Glycerolipid metabolism_Homo sapiens_hsa005610.36423600
93Oocyte meiosis_Homo sapiens_hsa041140.34941111
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34147232
95mRNA surveillance pathway_Homo sapiens_hsa030150.33966384
96Pyrimidine metabolism_Homo sapiens_hsa002400.33285467
97Mineral absorption_Homo sapiens_hsa049780.30351619
98Caffeine metabolism_Homo sapiens_hsa002320.29979545
99Vitamin digestion and absorption_Homo sapiens_hsa049770.29011887
100Glucagon signaling pathway_Homo sapiens_hsa049220.28551509
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26847642
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26453971
103Steroid biosynthesis_Homo sapiens_hsa001000.24742837
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.24630937
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24394616
106Pancreatic secretion_Homo sapiens_hsa049720.23453087
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22540512
108Synaptic vesicle cycle_Homo sapiens_hsa047210.22340130
109Purine metabolism_Homo sapiens_hsa002300.22110919
110Selenocompound metabolism_Homo sapiens_hsa004500.21299828
111Systemic lupus erythematosus_Homo sapiens_hsa053220.20511574
112Calcium signaling pathway_Homo sapiens_hsa040200.20402590
113Fatty acid biosynthesis_Homo sapiens_hsa000610.20148706
114Complement and coagulation cascades_Homo sapiens_hsa046100.18896163
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18864640
116Taste transduction_Homo sapiens_hsa047420.17609369
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16843183
118GABAergic synapse_Homo sapiens_hsa047270.16110162
119Epstein-Barr virus infection_Homo sapiens_hsa051690.15630212
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.14833253
121Nitrogen metabolism_Homo sapiens_hsa009100.14336466
122Ether lipid metabolism_Homo sapiens_hsa005650.13535899
123Regulation of autophagy_Homo sapiens_hsa041400.13234537
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12605811
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.12374364
126Nicotine addiction_Homo sapiens_hsa050330.11156792
127ABC transporters_Homo sapiens_hsa020100.08235449
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.07285490
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06747286

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