NDUFC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)9.78820829
2ATP synthesis coupled proton transport (GO:0015986)9.78820829
3* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.43519305
4* respiratory electron transport chain (GO:0022904)8.47918092
5* electron transport chain (GO:0022900)8.26814930
6protein complex biogenesis (GO:0070271)5.51802441
7chaperone-mediated protein transport (GO:0072321)5.31946295
8ATP biosynthetic process (GO:0006754)5.30689372
9protein neddylation (GO:0045116)5.19411785
10hydrogen ion transmembrane transport (GO:1902600)5.18274876
11establishment of protein localization to mitochondrial membrane (GO:0090151)5.17715172
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.17151438
13mitochondrial respiratory chain complex I assembly (GO:0032981)5.17151438
14NADH dehydrogenase complex assembly (GO:0010257)5.17151438
15purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.16587482
16purine nucleoside triphosphate biosynthetic process (GO:0009145)5.04788421
17mitochondrial respiratory chain complex assembly (GO:0033108)4.92532555
18GTP biosynthetic process (GO:0006183)4.67230865
19proton transport (GO:0015992)4.54970333
20oxidative phosphorylation (GO:0006119)4.54032328
21ribonucleoside triphosphate biosynthetic process (GO:0009201)4.47060863
22hydrogen transport (GO:0006818)4.46563462
23inner mitochondrial membrane organization (GO:0007007)4.45548349
24regulation of mitochondrial translation (GO:0070129)4.34626134
25ribosomal small subunit biogenesis (GO:0042274)4.16269897
26nucleoside triphosphate biosynthetic process (GO:0009142)3.84778750
27UTP biosynthetic process (GO:0006228)3.77516602
28viral transcription (GO:0019083)3.74411695
29water-soluble vitamin biosynthetic process (GO:0042364)3.66980432
30respiratory chain complex IV assembly (GO:0008535)3.66913110
31translational termination (GO:0006415)3.57702812
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54423764
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51946893
34cotranslational protein targeting to membrane (GO:0006613)3.50618288
35cytochrome complex assembly (GO:0017004)3.47286778
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45102477
37protein targeting to ER (GO:0045047)3.43148648
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.41502399
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.41502399
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40359060
41protein targeting to mitochondrion (GO:0006626)3.37535677
42aerobic respiration (GO:0009060)3.36909035
43dopamine transport (GO:0015872)3.34219490
44regulation of oxidative phosphorylation (GO:0002082)3.32878755
45establishment of protein localization to mitochondrion (GO:0072655)3.32321248
46guanosine-containing compound biosynthetic process (GO:1901070)3.31616827
47proteasome assembly (GO:0043248)3.31042350
48mitochondrial transport (GO:0006839)3.30170431
49establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29550173
50protein localization to endoplasmic reticulum (GO:0070972)3.29351661
51ATP hydrolysis coupled proton transport (GO:0015991)3.29329704
52energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.29329704
53UTP metabolic process (GO:0046051)3.27389816
54rRNA modification (GO:0000154)3.27071596
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24556446
56pseudouridine synthesis (GO:0001522)3.20902383
57platelet dense granule organization (GO:0060155)3.19922543
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18523122
59protein localization to mitochondrion (GO:0070585)3.17212223
60nucleoside diphosphate phosphorylation (GO:0006165)3.15855334
61negative regulation of ligase activity (GO:0051352)3.14837628
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14837628
63CTP biosynthetic process (GO:0006241)3.07038654
64CTP metabolic process (GO:0046036)3.07038654
65central nervous system myelination (GO:0022010)3.02181884
66axon ensheathment in central nervous system (GO:0032291)3.02181884
67protein deneddylation (GO:0000338)3.01780244
68DNA damage response, detection of DNA damage (GO:0042769)3.01306252
69negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.00134889
70spliceosomal snRNP assembly (GO:0000387)3.00125558
71sequestering of actin monomers (GO:0042989)3.00062792
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99147740
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98279712
74ribosomal large subunit biogenesis (GO:0042273)2.97873016
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.96155109
76peptidyl-histidine modification (GO:0018202)2.94793998
77* generation of precursor metabolites and energy (GO:0006091)2.92928664
78substantia nigra development (GO:0021762)2.92727761
79ubiquinone biosynthetic process (GO:0006744)2.92446186
80quinone biosynthetic process (GO:1901663)2.92446186
81translation (GO:0006412)2.91358526
82signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90542742
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90542742
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90542742
85cellular protein complex disassembly (GO:0043624)2.89282139
86mitochondrion morphogenesis (GO:0070584)2.89134588
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87979375
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87979375
89chromatin remodeling at centromere (GO:0031055)2.87933918
90purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.87912471
91purine nucleoside monophosphate biosynthetic process (GO:0009127)2.87912471
92intracellular protein transmembrane import (GO:0044743)2.87619436
93viral life cycle (GO:0019058)2.85740138
94translational elongation (GO:0006414)2.84143935
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.83993560
96termination of RNA polymerase III transcription (GO:0006386)2.83993560
97CENP-A containing nucleosome assembly (GO:0034080)2.81917211
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81507658
99regulation of cellular respiration (GO:0043457)2.81234344
100ubiquinone metabolic process (GO:0006743)2.77440073
101protein-cofactor linkage (GO:0018065)2.76935028
102signal transduction involved in DNA damage checkpoint (GO:0072422)2.76025652
103signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76025652
104signal transduction involved in cell cycle checkpoint (GO:0072395)2.75318098
105DNA deamination (GO:0045006)2.71904907
106pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70125788
107long-chain fatty acid biosynthetic process (GO:0042759)2.68366196
108positive regulation of ligase activity (GO:0051351)2.68365684
109fatty acid elongation (GO:0030497)2.68002104
110purine nucleoside biosynthetic process (GO:0042451)2.66196288
111purine ribonucleoside biosynthetic process (GO:0046129)2.66196288
112dopamine biosynthetic process (GO:0042416)2.65272599
113cullin deneddylation (GO:0010388)2.65017722
114epithelial cilium movement (GO:0003351)2.64486066
115cellular respiration (GO:0045333)2.64369145
116organelle disassembly (GO:1903008)2.62652315
117ribosomal small subunit assembly (GO:0000028)2.61272271
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60928874
119protein targeting to membrane (GO:0006612)2.60568559
120regulation of dopamine metabolic process (GO:0042053)2.58912928
121regulation of catecholamine metabolic process (GO:0042069)2.58912928
122neuron cell-cell adhesion (GO:0007158)2.58228392
123regulation of cellular amino acid metabolic process (GO:0006521)2.58101382
124presynaptic membrane assembly (GO:0097105)2.52942928
125pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.51927674
126calcium-mediated signaling using intracellular calcium source (GO:0035584)2.49857964
127regulation of cell communication by electrical coupling (GO:0010649)2.49154673
128tricarboxylic acid cycle (GO:0006099)2.42365475
129cellular component biogenesis (GO:0044085)2.41450994
1307-methylguanosine mRNA capping (GO:0006370)2.38325959
131presynaptic membrane organization (GO:0097090)2.37543484
132RNA capping (GO:0036260)2.37409778
1337-methylguanosine RNA capping (GO:0009452)2.37409778
134pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.36071255
135heart process (GO:0003015)2.35605730
136heart contraction (GO:0060047)2.35605730
137translational initiation (GO:0006413)2.35564158
138maturation of SSU-rRNA (GO:0030490)2.35333002
139mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.3585271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.03163492
2EZH2_22144423_ChIP-Seq_EOC_Human3.96825966
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.47791087
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38221330
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38020971
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.88483303
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54001843
8VDR_22108803_ChIP-Seq_LS180_Human2.53477577
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.49421600
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44099030
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38999640
12GBX2_23144817_ChIP-Seq_PC3_Human2.29217232
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28853125
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27532326
15TAF15_26573619_Chip-Seq_HEK293_Human2.22369747
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07864356
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02838490
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00203955
19FOXP3_21729870_ChIP-Seq_TREG_Human1.99638039
20* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.96794737
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.94368211
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89917925
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89429566
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89049255
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86706791
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.84848456
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.84735316
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81629580
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76811328
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75439961
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74681520
32FUS_26573619_Chip-Seq_HEK293_Human1.71503762
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70057167
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69808752
35* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63457812
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.62169990
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57885274
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57377333
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55632780
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52101348
41GABP_19822575_ChIP-Seq_HepG2_Human1.51831487
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49869089
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49018977
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48958478
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47400641
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46952689
47* SRF_21415370_ChIP-Seq_HL-1_Mouse1.46373659
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46215657
49XRN2_22483619_ChIP-Seq_HELA_Human1.45517303
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42811124
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42501054
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41952500
53ER_23166858_ChIP-Seq_MCF-7_Human1.40139348
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39442586
55* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37420994
56P300_19829295_ChIP-Seq_ESCs_Human1.36968426
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.36638329
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36468578
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.35379097
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34668189
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34416528
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32505961
63TP53_22573176_ChIP-Seq_HFKS_Human1.29223575
64IGF1R_20145208_ChIP-Seq_DFB_Human1.26583770
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25061878
66RNF2_27304074_Chip-Seq_NSC_Mouse1.24423070
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24263820
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24263820
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22300149
70* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20343652
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.19488247
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19197990
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18950820
74* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18854496
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18102867
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17918324
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17800610
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17797108
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17551402
80IRF1_19129219_ChIP-ChIP_H3396_Human1.16667604
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15221398
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14620406
83ELK1_19687146_ChIP-ChIP_HELA_Human1.14017111
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13386608
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.13004779
86REST_21632747_ChIP-Seq_MESCs_Mouse1.12566561
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10246029
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10097834
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09756785
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.09681655
91DCP1A_22483619_ChIP-Seq_HELA_Human1.09663135
92* ELK1_22589737_ChIP-Seq_MCF10A_Human1.09120653
93* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08360684
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05781592
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05308978
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04430596
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04164730
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.03193853
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02437149
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.99856725
101SOX2_19829295_ChIP-Seq_ESCs_Human0.99740203
102ZNF274_21170338_ChIP-Seq_K562_Hela0.99491677
103HTT_18923047_ChIP-ChIP_STHdh_Human0.97713991
104FOXA1_25329375_ChIP-Seq_VCAP_Human0.96757233
105FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96757233
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95643117
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95636109
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95455231
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94736007
110VDR_23849224_ChIP-Seq_CD4+_Human0.94643011
111ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94145595
112MYC_18940864_ChIP-ChIP_HL60_Human0.93752057
113SMAD3_21741376_ChIP-Seq_EPCs_Human0.93686821
114AR_20517297_ChIP-Seq_VCAP_Human0.93353694
115SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92815185
116STAT3_18555785_Chip-Seq_ESCs_Mouse0.92699955
117JUN_21703547_ChIP-Seq_K562_Human0.91365555
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91240668
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.90922809
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89865862
121MYC_18555785_ChIP-Seq_MESCs_Mouse0.89513216
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89421753
123EWS_26573619_Chip-Seq_HEK293_Human0.89274865
124P53_22387025_ChIP-Seq_ESCs_Mouse0.88479146
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.88380135
126* TTF2_22483619_ChIP-Seq_HELA_Human0.88193018
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88047100
128MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87299787
129NCOR_22424771_ChIP-Seq_293T_Human0.86743156
130SOX2_18555785_Chip-Seq_ESCs_Mouse0.86727915
131P300_18555785_Chip-Seq_ESCs_Mouse0.86724761
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.86267630
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.85684615
134NANOG_19829295_ChIP-Seq_ESCs_Human0.85351814
135CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85350785
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82848961
137SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81335118
138ERG_20517297_ChIP-Seq_VCAP_Human0.80864347
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79163433
140CBP_20019798_ChIP-Seq_JUKART_Human0.79163433
141POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.77549002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.17250031
2MP0009379_abnormal_foot_pigmentation3.83368582
3MP0001529_abnormal_vocalization3.56597969
4MP0002837_dystrophic_cardiac_calcinosis3.39393641
5MP0006276_abnormal_autonomic_nervous2.92558078
6MP0001905_abnormal_dopamine_level2.61497339
7MP0003136_yellow_coat_color2.40747347
8MP0003646_muscle_fatigue2.25489340
9MP0004142_abnormal_muscle_tone2.25197698
10MP0006036_abnormal_mitochondrial_physio2.23389993
11MP0002736_abnormal_nociception_after2.21378253
12MP0003806_abnormal_nucleotide_metabolis2.16609844
13MP0000751_myopathy2.15577205
14MP0008058_abnormal_DNA_repair2.10770507
15MP0001968_abnormal_touch/_nociception2.09552013
16MP0004215_abnormal_myocardial_fiber2.05604315
17MP0001440_abnormal_grooming_behavior1.94275650
18MP0006035_abnormal_mitochondrial_morpho1.93075545
19MP0002272_abnormal_nervous_system1.90753484
20MP0009046_muscle_twitch1.89012824
21MP0009745_abnormal_behavioral_response1.83964687
22MP0002638_abnormal_pupillary_reflex1.82400609
23MP0005084_abnormal_gallbladder_morpholo1.80360972
24MP0000749_muscle_degeneration1.80064754
25MP0002064_seizures1.76106958
26MP0008789_abnormal_olfactory_epithelium1.72494859
27MP0004145_abnormal_muscle_electrophysio1.68388967
28MP0005423_abnormal_somatic_nervous1.67799643
29MP0004036_abnormal_muscle_relaxation1.64877598
30MP0001486_abnormal_startle_reflex1.61201066
31MP0001188_hyperpigmentation1.61118102
32MP0002734_abnormal_mechanical_nocicepti1.60216326
33MP0008877_abnormal_DNA_methylation1.59663298
34MP0003137_abnormal_impulse_conducting1.59128245
35MP0006072_abnormal_retinal_apoptosis1.57740904
36MP0003635_abnormal_synaptic_transmissio1.55747196
37MP0002572_abnormal_emotion/affect_behav1.54557833
38MP0005379_endocrine/exocrine_gland_phen1.53046378
39MP0004147_increased_porphyrin_level1.52422195
40MP0002067_abnormal_sensory_capabilities1.49120192
41MP0002234_abnormal_pharynx_morphology1.48668047
42MP0002735_abnormal_chemical_nociception1.47951960
43MP0001485_abnormal_pinna_reflex1.47819251
44MP0002163_abnormal_gland_morphology1.47128669
45MP0010386_abnormal_urinary_bladder1.47119328
46MP0005409_darkened_coat_color1.46780332
47MP0004742_abnormal_vestibular_system1.41546359
48MP0003122_maternal_imprinting1.39996425
49MP0002822_catalepsy1.39301757
50MP0001986_abnormal_taste_sensitivity1.39044815
51MP0001970_abnormal_pain_threshold1.38873309
52MP0004924_abnormal_behavior1.38527834
53MP0005386_behavior/neurological_phenoty1.38527834
54MP0002876_abnormal_thyroid_physiology1.37838687
55MP0004133_heterotaxia1.37756911
56MP0001293_anophthalmia1.37312926
57MP0008995_early_reproductive_senescence1.35188166
58MP0004270_analgesia1.34571507
59MP0008875_abnormal_xenobiotic_pharmacok1.32356481
60MP0004043_abnormal_pH_regulation1.31249878
61MP0006292_abnormal_olfactory_placode1.31137845
62MP0001984_abnormal_olfaction1.29156387
63MP0005330_cardiomyopathy1.29090407
64MP0005171_absent_coat_pigmentation1.28228778
65MP0002332_abnormal_exercise_endurance1.26050496
66MP0000372_irregular_coat_pigmentation1.24998952
67MP0004484_altered_response_of1.23997412
68MP0001501_abnormal_sleep_pattern1.23816589
69MP0002063_abnormal_learning/memory/cond1.23124113
70MP0005551_abnormal_eye_electrophysiolog1.22751973
71MP0002733_abnormal_thermal_nociception1.21758776
72MP0005645_abnormal_hypothalamus_physiol1.20930221
73MP0004084_abnormal_cardiac_muscle1.20301586
74MP0002653_abnormal_ependyma_morphology1.17065096
75MP0003121_genomic_imprinting1.16905924
76MP0010030_abnormal_orbit_morphology1.14247486
77MP0003786_premature_aging1.13554370
78MP0005394_taste/olfaction_phenotype1.12937082
79MP0005499_abnormal_olfactory_system1.12937082
80MP0002160_abnormal_reproductive_system1.12525039
81MP0002972_abnormal_cardiac_muscle1.11801117
82MP0005620_abnormal_muscle_contractility1.09744653
83MP0008872_abnormal_physiological_respon1.08754218
84MP0002277_abnormal_respiratory_mucosa1.08322190
85MP0002184_abnormal_innervation1.07302724
86MP0005408_hypopigmentation1.06466829
87MP0003195_calcinosis1.06318762
88MP0002090_abnormal_vision1.05972733
89MP0000778_abnormal_nervous_system1.05261738
90MP0000026_abnormal_inner_ear1.03831994
91MP0004381_abnormal_hair_follicle1.03144990
92MP0002102_abnormal_ear_morphology1.03142491
93MP0005332_abnormal_amino_acid1.02664781
94MP0001727_abnormal_embryo_implantation1.02027245
95MP0005253_abnormal_eye_physiology1.01482874
96MP0001664_abnormal_digestion1.01190305
97MP0000049_abnormal_middle_ear1.00975312
98MP0002557_abnormal_social/conspecific_i1.00435894
99MP0004085_abnormal_heartbeat0.99985836
100MP0004957_abnormal_blastocyst_morpholog0.99546956
101MP0001963_abnormal_hearing_physiology0.99236979
102MP0001764_abnormal_homeostasis0.98454866
103MP0002106_abnormal_muscle_physiology0.97735416
104MP0003938_abnormal_ear_development0.97441881
105MP0004885_abnormal_endolymph0.96472762
106MP0010094_abnormal_chromosome_stability0.94724957
107MP0005410_abnormal_fertilization0.93659260
108MP0003787_abnormal_imprinting0.93625432
109MP0002095_abnormal_skin_pigmentation0.93368361
110MP0005535_abnormal_body_temperature0.89712490
111MP0002752_abnormal_somatic_nervous0.89705620
112MP0003567_abnormal_fetal_cardiomyocyte0.89465287
113MP0000920_abnormal_myelination0.89457354
114MP0002229_neurodegeneration0.88856073
115MP0002066_abnormal_motor_capabilities/c0.88118456
116MP0003693_abnormal_embryo_hatching0.87628868
117MP0003718_maternal_effect0.86537656
118MP0003123_paternal_imprinting0.86275566
119MP0005636_abnormal_mineral_homeostasis0.86101155
120MP0005369_muscle_phenotype0.86008730
121MP0003315_abnormal_perineum_morphology0.85963426
122MP0005646_abnormal_pituitary_gland0.85855012
123MP0002751_abnormal_autonomic_nervous0.85602390
124MP0002210_abnormal_sex_determination0.84705171
125MP0005389_reproductive_system_phenotype0.84478112
126MP0005195_abnormal_posterior_eye0.83122292
127MP0000750_abnormal_muscle_regeneration0.82339512
128MP0003950_abnormal_plasma_membrane0.81245859
129MP0002938_white_spotting0.80059927
130MP0005367_renal/urinary_system_phenotyp0.79582044
131MP0000516_abnormal_urinary_system0.79582044
132MP0005075_abnormal_melanosome_morpholog0.79457880
133MP0000538_abnormal_urinary_bladder0.79412697
134MP0002882_abnormal_neuron_morphology0.79392800
135MP0000230_abnormal_systemic_arterial0.79335224
136MP0002909_abnormal_adrenal_gland0.78445896
137MP0000631_abnormal_neuroendocrine_gland0.77635705
138MP0008004_abnormal_stomach_pH0.77569944
139MP0008932_abnormal_embryonic_tissue0.77550286
140MP0005187_abnormal_penis_morphology0.75379020
141MP0003186_abnormal_redox_activity0.74161983
142MP0009697_abnormal_copulation0.74074217
143MP0003011_delayed_dark_adaptation0.74017416

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.80487691
2Abnormal mitochondria in muscle tissue (HP:0008316)7.06009236
3Mitochondrial inheritance (HP:0001427)6.77458396
4Progressive macrocephaly (HP:0004481)6.64776219
5Acute encephalopathy (HP:0006846)6.41396670
6Increased CSF lactate (HP:0002490)5.70527024
7Hepatocellular necrosis (HP:0001404)5.69541638
8Increased hepatocellular lipid droplets (HP:0006565)5.13251850
9Hepatic necrosis (HP:0002605)5.10742338
10Lipid accumulation in hepatocytes (HP:0006561)4.67040597
11Cerebral edema (HP:0002181)4.52251089
12Renal Fanconi syndrome (HP:0001994)4.44232122
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.42981994
14Optic disc pallor (HP:0000543)4.17292613
15Exercise intolerance (HP:0003546)4.06960092
16Respiratory failure (HP:0002878)4.01879020
17Increased intramyocellular lipid droplets (HP:0012240)3.98169666
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.93949812
19Lactic acidosis (HP:0003128)3.84150218
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.82730571
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.82730571
22Leukodystrophy (HP:0002415)3.68318914
233-Methylglutaconic aciduria (HP:0003535)3.66648279
24Increased muscle lipid content (HP:0009058)3.47006558
25Increased serum pyruvate (HP:0003542)3.44972776
26Abnormality of glycolysis (HP:0004366)3.44972776
27Increased serum lactate (HP:0002151)3.39699986
28Exertional dyspnea (HP:0002875)3.22329563
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.15883757
30Abnormality of renal resorption (HP:0011038)3.13196608
31Pancreatic fibrosis (HP:0100732)2.97499175
32Pancreatic cysts (HP:0001737)2.92122490
33True hermaphroditism (HP:0010459)2.80953225
34Molar tooth sign on MRI (HP:0002419)2.74613588
35Abnormality of midbrain morphology (HP:0002418)2.74613588
36Muscle hypertrophy of the lower extremities (HP:0008968)2.73634237
37Parakeratosis (HP:0001036)2.72156814
38Pheochromocytoma (HP:0002666)2.72141348
39X-linked dominant inheritance (HP:0001423)2.70509831
40Respiratory difficulties (HP:0002880)2.69768302
41Neuroendocrine neoplasm (HP:0100634)2.68363506
42Congenital, generalized hypertrichosis (HP:0004540)2.63459468
43Hyperglycinemia (HP:0002154)2.61755254
44Calf muscle hypertrophy (HP:0008981)2.51513811
45Abnormality of cells of the erythroid lineage (HP:0012130)2.46484323
46Glycosuria (HP:0003076)2.45654640
47Abnormality of urine glucose concentration (HP:0011016)2.45654640
48CNS demyelination (HP:0007305)2.43860602
49Nephronophthisis (HP:0000090)2.36384518
50Lethargy (HP:0001254)2.31083451
51Type I transferrin isoform profile (HP:0003642)2.30841263
52Hyperphosphaturia (HP:0003109)2.30782497
53Emotional lability (HP:0000712)2.25925570
54Hypothermia (HP:0002045)2.23645476
55Generalized aminoaciduria (HP:0002909)2.22740901
56Abnormal ciliary motility (HP:0012262)2.19072363
57Focal motor seizures (HP:0011153)2.13594897
58Medial flaring of the eyebrow (HP:0010747)2.13449502
59Congenital ichthyosiform erythroderma (HP:0007431)2.11397284
60Myokymia (HP:0002411)2.09632115
61Colon cancer (HP:0003003)2.09389106
62Methylmalonic acidemia (HP:0002912)2.06515252
63Methylmalonic aciduria (HP:0012120)2.06064156
64Abnormal pupillary function (HP:0007686)2.05905144
65Macrocytic anemia (HP:0001972)2.05570807
66Sudden death (HP:0001699)2.05064894
67Limb dystonia (HP:0002451)2.04854634
68Progressive external ophthalmoplegia (HP:0000590)2.02861064
69Abnormality of the anterior horn cell (HP:0006802)2.02322767
70Degeneration of anterior horn cells (HP:0002398)2.02322767
71Sclerocornea (HP:0000647)2.01995692
72Abnormal number of erythroid precursors (HP:0012131)2.01966990
73Septo-optic dysplasia (HP:0100842)1.99811708
74Abnormality of the labia minora (HP:0012880)1.99549489
75Abnormal respiratory motile cilium morphology (HP:0005938)1.98955845
76Abnormal respiratory epithelium morphology (HP:0012253)1.98955845
77Abnormal urine phosphate concentration (HP:0012599)1.98490494
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98239701
79Abnormality of alanine metabolism (HP:0010916)1.98239701
80Hyperalaninemia (HP:0003348)1.98239701
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.95541871
82Absent/shortened dynein arms (HP:0200106)1.95541871
83Microvesicular hepatic steatosis (HP:0001414)1.95472261
84Palpitations (HP:0001962)1.91181817
85Amniotic constriction ring (HP:0009775)1.87116014
86Abnormality of placental membranes (HP:0011409)1.87116014
87Abnormality of serum amino acid levels (HP:0003112)1.86481096
88Renal tubular dysfunction (HP:0000124)1.84374458
89Aplastic anemia (HP:0001915)1.83755808
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82910130
91Abnormal protein N-linked glycosylation (HP:0012347)1.82910130
92Abnormal protein glycosylation (HP:0012346)1.82910130
93Abnormal glycosylation (HP:0012345)1.82910130
94Abnormal respiratory motile cilium physiology (HP:0012261)1.81974891
95Abnormality of vitamin B metabolism (HP:0004340)1.81620753
96Male pseudohermaphroditism (HP:0000037)1.80968105
97Hyperglycinuria (HP:0003108)1.78993332
98Abnormality of the renal medulla (HP:0100957)1.78423832
99Gait imbalance (HP:0002141)1.76958121
100Exercise-induced muscle cramps (HP:0003710)1.75891512
101Abnormality of the calf musculature (HP:0001430)1.75768246
102Blindness (HP:0000618)1.74587527
103Hypoplastic left heart (HP:0004383)1.73740251
104Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73566065
105Dicarboxylic aciduria (HP:0003215)1.73566065
106Abnormality of serine family amino acid metabolism (HP:0010894)1.72928388
107Abnormality of glycine metabolism (HP:0010895)1.72928388
108Congenital primary aphakia (HP:0007707)1.72793981
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72450862
110Sensory axonal neuropathy (HP:0003390)1.70032500
111Reticulocytopenia (HP:0001896)1.69093648
112Gliosis (HP:0002171)1.68088164
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.67283660
114Anencephaly (HP:0002323)1.65665899
115Hypoglycemic coma (HP:0001325)1.65433611
116Exercise-induced myalgia (HP:0003738)1.65036972
117Vomiting (HP:0002013)1.64580781
118Conjunctival hamartoma (HP:0100780)1.62702400
119Retinal dysplasia (HP:0007973)1.61475840
120Abnormality of aromatic amino acid family metabolism (HP:0004338)1.61414489
121Abnormality of the vitamin B12 metabolism (HP:0004341)1.61029735
122Prolonged QT interval (HP:0001657)1.60931025
123Nephrogenic diabetes insipidus (HP:0009806)1.60238632
124Congenital stationary night blindness (HP:0007642)1.58495591
125Myotonia (HP:0002486)1.58223473
126Oral leukoplakia (HP:0002745)1.58015554
127Congenital sensorineural hearing impairment (HP:0008527)1.56804386
128Abnormality of the renal cortex (HP:0011035)1.56568044
129Cerebral hemorrhage (HP:0001342)1.55870893
130Progressive inability to walk (HP:0002505)1.55724888
131Vaginal atresia (HP:0000148)1.55468322
132Genital tract atresia (HP:0001827)1.55221336
133Aplasia/hypoplasia of the uterus (HP:0008684)1.54987144
134Hyperventilation (HP:0002883)1.53100988
135Rimmed vacuoles (HP:0003805)1.52213968
136Syncope (HP:0001279)1.51661058
137Hypoplastic heart (HP:0001961)1.51416941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.99703417
2NME13.55863252
3STK163.13531787
4STK392.96294265
5CASK2.96258352
6MAP3K122.78470180
7NME22.63723475
8MAP4K22.40948602
9MYLK2.38427712
10PBK2.38232985
11PNCK2.24786128
12GRK72.10828142
13WNK42.09452231
14MST42.04395644
15MUSK1.99308414
16OXSR11.98387401
17OBSCN1.89799676
18TLK11.81353945
19BCR1.78846152
20TNIK1.77795901
21ARAF1.72224062
22MAP2K71.69286391
23CDC71.68108263
24TRIM281.68107385
25NEK11.66988529
26GRK51.57928072
27BMPR1B1.54766565
28ADRBK21.41465105
29FRK1.40422931
30CDK191.36480529
31VRK11.35273428
32PLK31.33279031
33LIMK11.32848510
34MARK11.27903482
35PHKG21.27368731
36PHKG11.27368731
37BRAF1.23673323
38CAMK2D1.16760544
39IRAK21.16234678
40PIK3CA1.13896677
41CAMK2B1.12764323
42BMPR21.12043004
43IRAK31.09734818
44PKN11.08879715
45ERBB31.08620597
46LMTK21.08038353
47PLK21.06498415
48WEE11.06211114
49CAMK2A1.05834918
50MAPKAPK51.03899526
51MKNK11.02180815
52DYRK31.01647647
53DYRK21.01422843
54BUB11.01186162
55NTRK31.00436878
56ADRBK10.98473741
57PINK10.96969354
58CAMK2G0.92942548
59PLK10.91657039
60TAF10.90786320
61ZAK0.90770946
62EPHA40.89601532
63MAPK130.87561483
64UHMK10.87382657
65WNK30.86983448
66TSSK60.86564231
67PDK40.85058548
68PDK30.85058548
69MAP3K40.83708381
70TTK0.80885231
71PRKCE0.79510472
72IRAK10.77241106
73STK38L0.76598554
74CSNK1G30.74221034
75BCKDK0.73875767
76CSNK1A1L0.71861719
77ABL20.70461181
78MAPK150.70327938
79ROCK20.68761155
80RIPK40.68530209
81CCNB10.66400708
82SRPK10.65659177
83FGR0.65403060
84PRKACA0.65305189
85CSNK2A20.64727096
86EIF2AK10.64491134
87TESK10.64048427
88PIK3CG0.61524467
89NUAK10.60733018
90AURKB0.59787324
91KDR0.58514436
92DAPK30.58229880
93PDK20.58065722
94EIF2AK30.58046901
95TIE10.57930431
96MAP2K20.57757531
97MINK10.57567433
98GRK10.55174342
99PRKCG0.54957198
100BRSK20.53653295
101CSNK1A10.52830700
102TESK20.51523857
103ATR0.51425950
104PIM20.49986010
105TAOK30.49466301
106NEK60.49457788
107MST1R0.49303727
108IRAK40.49294815
109MAP2K40.49216737
110WNK10.48853989
111RPS6KA40.46518412
112ILK0.45462424
113DAPK10.44337002
114YES10.44143987
115PAK30.44141162
116CDK140.44129975
117CSNK1G10.44017021
118EPHB20.42537263
119CHEK20.42103012
120AURKA0.41630496
121INSRR0.41503613
122STK240.40727778
123MKNK20.40219315
124RPS6KA50.40072515
125CSNK1E0.39918052
126CSNK2A10.39152203
127PLK40.38818959
128PRKG10.38642083
129CSNK1G20.38431744
130AKT30.38280892
131NTRK20.37021789

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.95641279
2Parkinsons disease_Homo sapiens_hsa050125.90046315
3Alzheimers disease_Homo sapiens_hsa050104.54153758
4Huntingtons disease_Homo sapiens_hsa050164.21542132
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.73056458
6Ribosome_Homo sapiens_hsa030103.67611802
7Cardiac muscle contraction_Homo sapiens_hsa042603.34531792
8Proteasome_Homo sapiens_hsa030502.73008826
9Protein export_Homo sapiens_hsa030602.50660771
10Collecting duct acid secretion_Homo sapiens_hsa049661.96959023
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95725319
12RNA polymerase_Homo sapiens_hsa030201.90127541
13Fatty acid elongation_Homo sapiens_hsa000621.83307154
14Mismatch repair_Homo sapiens_hsa034301.79737640
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68361852
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48767304
17Sulfur metabolism_Homo sapiens_hsa009201.48465985
18Nicotine addiction_Homo sapiens_hsa050331.47262678
19DNA replication_Homo sapiens_hsa030301.44027753
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39521623
21Vibrio cholerae infection_Homo sapiens_hsa051101.30564632
22RNA degradation_Homo sapiens_hsa030181.28863417
23Propanoate metabolism_Homo sapiens_hsa006401.21335035
24Fanconi anemia pathway_Homo sapiens_hsa034601.19253953
25One carbon pool by folate_Homo sapiens_hsa006701.07168619
26Pyruvate metabolism_Homo sapiens_hsa006201.06252117
27Base excision repair_Homo sapiens_hsa034101.02660268
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98580505
29Phototransduction_Homo sapiens_hsa047440.97898255
30Synaptic vesicle cycle_Homo sapiens_hsa047210.93778947
31RNA transport_Homo sapiens_hsa030130.92950396
32Nitrogen metabolism_Homo sapiens_hsa009100.92132791
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91089786
34Pyrimidine metabolism_Homo sapiens_hsa002400.91078781
35Serotonergic synapse_Homo sapiens_hsa047260.90945428
36* Metabolic pathways_Homo sapiens_hsa011000.89000441
37Butanoate metabolism_Homo sapiens_hsa006500.88881428
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87770139
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86614785
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.82203090
41Taste transduction_Homo sapiens_hsa047420.79106037
42Arachidonic acid metabolism_Homo sapiens_hsa005900.78575752
43Tryptophan metabolism_Homo sapiens_hsa003800.77730097
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76434082
45Rheumatoid arthritis_Homo sapiens_hsa053230.75463181
46Ether lipid metabolism_Homo sapiens_hsa005650.75048041
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74438610
48Chemical carcinogenesis_Homo sapiens_hsa052040.73592237
49Purine metabolism_Homo sapiens_hsa002300.69074032
50Linoleic acid metabolism_Homo sapiens_hsa005910.68868829
51GABAergic synapse_Homo sapiens_hsa047270.68740203
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68123893
53Tyrosine metabolism_Homo sapiens_hsa003500.67768380
54Steroid biosynthesis_Homo sapiens_hsa001000.67499003
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65864793
56Non-homologous end-joining_Homo sapiens_hsa034500.61840489
57Selenocompound metabolism_Homo sapiens_hsa004500.61017348
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59264675
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58302364
60Morphine addiction_Homo sapiens_hsa050320.58233847
61Glutathione metabolism_Homo sapiens_hsa004800.56756702
62Carbon metabolism_Homo sapiens_hsa012000.56208970
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56173429
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.56170257
65Caffeine metabolism_Homo sapiens_hsa002320.55287931
66Sphingolipid metabolism_Homo sapiens_hsa006000.52657280
67Retinol metabolism_Homo sapiens_hsa008300.49505123
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48743568
69Calcium signaling pathway_Homo sapiens_hsa040200.48276966
70Phenylalanine metabolism_Homo sapiens_hsa003600.47184356
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45943973
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45807071
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45535958
74Amphetamine addiction_Homo sapiens_hsa050310.45122426
75Basal transcription factors_Homo sapiens_hsa030220.44727636
76Arginine and proline metabolism_Homo sapiens_hsa003300.44259952
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43812525
78Folate biosynthesis_Homo sapiens_hsa007900.43473334
79Peroxisome_Homo sapiens_hsa041460.42491594
80Glutamatergic synapse_Homo sapiens_hsa047240.41828724
81Vitamin digestion and absorption_Homo sapiens_hsa049770.40332112
82Circadian entrainment_Homo sapiens_hsa047130.39383590
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38691126
84Vitamin B6 metabolism_Homo sapiens_hsa007500.38179227
85Homologous recombination_Homo sapiens_hsa034400.37924605
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37880225
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.37687371
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37260874
89Dopaminergic synapse_Homo sapiens_hsa047280.37097065
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36801344
91Phagosome_Homo sapiens_hsa041450.36180954
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36015214
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.34976573
94Histidine metabolism_Homo sapiens_hsa003400.34859390
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34815243
96Nucleotide excision repair_Homo sapiens_hsa034200.34451780
97Dilated cardiomyopathy_Homo sapiens_hsa054140.33252524
98Renin secretion_Homo sapiens_hsa049240.32587059
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32415827
100Fat digestion and absorption_Homo sapiens_hsa049750.32182077
101Sulfur relay system_Homo sapiens_hsa041220.31725500
102Cocaine addiction_Homo sapiens_hsa050300.30678629
103Long-term depression_Homo sapiens_hsa047300.30433909
104Oocyte meiosis_Homo sapiens_hsa041140.30341693
105Mineral absorption_Homo sapiens_hsa049780.29960957
106Regulation of autophagy_Homo sapiens_hsa041400.27613903
107Fatty acid metabolism_Homo sapiens_hsa012120.26654818
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26570328
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26536174
110Cholinergic synapse_Homo sapiens_hsa047250.26499387
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26142882
112Graft-versus-host disease_Homo sapiens_hsa053320.26137091
113Spliceosome_Homo sapiens_hsa030400.26008685
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.24747330
115Salivary secretion_Homo sapiens_hsa049700.24003336
116Biosynthesis of amino acids_Homo sapiens_hsa012300.23022007
117Autoimmune thyroid disease_Homo sapiens_hsa053200.22108090
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.21956159
119Olfactory transduction_Homo sapiens_hsa047400.21629607
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20767343
121Insulin secretion_Homo sapiens_hsa049110.20314786
122Gastric acid secretion_Homo sapiens_hsa049710.20193432
123Circadian rhythm_Homo sapiens_hsa047100.20010128
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19978867
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18272290
126Long-term potentiation_Homo sapiens_hsa047200.17921734
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17837321
128beta-Alanine metabolism_Homo sapiens_hsa004100.16395447
129Fatty acid degradation_Homo sapiens_hsa000710.15615388
130Asthma_Homo sapiens_hsa053100.15397292
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15306406
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14149862
133Pancreatic secretion_Homo sapiens_hsa049720.13808622
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.12932836

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