NDUFC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)9.78539747
2ATP synthesis coupled proton transport (GO:0015986)9.78539747
3* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)9.11669499
4* respiratory electron transport chain (GO:0022904)8.49905747
5* electron transport chain (GO:0022900)8.28137755
6chaperone-mediated protein transport (GO:0072321)5.92479564
7protein complex biogenesis (GO:0070271)5.55664188
8mitochondrial respiratory chain complex I assembly (GO:0032981)5.41835230
9NADH dehydrogenase complex assembly (GO:0010257)5.41835230
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.41835230
11ATP biosynthetic process (GO:0006754)5.33517957
12protein neddylation (GO:0045116)5.25407014
13hydrogen ion transmembrane transport (GO:1902600)5.24669525
14inner mitochondrial membrane organization (GO:0007007)5.03733641
15purine ribonucleoside triphosphate biosynthetic process (GO:0009206)5.03319665
16mitochondrial respiratory chain complex assembly (GO:0033108)5.01892868
17purine nucleoside triphosphate biosynthetic process (GO:0009145)4.97334816
18oxidative phosphorylation (GO:0006119)4.89234253
19establishment of protein localization to mitochondrial membrane (GO:0090151)4.89222032
20proton transport (GO:0015992)4.65656938
21hydrogen transport (GO:0006818)4.57948487
22ribonucleoside triphosphate biosynthetic process (GO:0009201)4.37750444
23GTP biosynthetic process (GO:0006183)3.97625644
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90346129
25melanin biosynthetic process (GO:0042438)3.89221391
26nucleoside triphosphate biosynthetic process (GO:0009142)3.76070843
27axon ensheathment in central nervous system (GO:0032291)3.75351449
28central nervous system myelination (GO:0022010)3.75351449
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71849282
30secondary metabolite biosynthetic process (GO:0044550)3.70812658
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69413024
32aerobic respiration (GO:0009060)3.63757640
33regulation of mitochondrial translation (GO:0070129)3.61358237
34protein targeting to mitochondrion (GO:0006626)3.59801374
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57881903
36negative regulation of ligase activity (GO:0051352)3.57881903
37respiratory chain complex IV assembly (GO:0008535)3.56682417
38energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.51855753
39ATP hydrolysis coupled proton transport (GO:0015991)3.51855753
40DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.51842515
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48860898
42mitochondrial transport (GO:0006839)3.48438424
43viral transcription (GO:0019083)3.47452216
44establishment of protein localization to mitochondrion (GO:0072655)3.47356649
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40877135
46signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40877135
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.40654393
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.40654393
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.40654393
50fatty acid elongation (GO:0030497)3.40228298
51cotranslational protein targeting to membrane (GO:0006613)3.38879549
52protein localization to mitochondrion (GO:0070585)3.38422833
53substantia nigra development (GO:0021762)3.31786279
54termination of RNA polymerase III transcription (GO:0006386)3.31613013
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.31613013
56translational termination (GO:0006415)3.30326228
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29874467
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29874467
59regulation of oxidative phosphorylation (GO:0002082)3.29648904
60ribosomal small subunit biogenesis (GO:0042274)3.29451455
61protein targeting to ER (GO:0045047)3.29430898
62signal transduction involved in DNA damage checkpoint (GO:0072422)3.27832377
63signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27832377
64melanin metabolic process (GO:0006582)3.27296699
65cytochrome complex assembly (GO:0017004)3.26990019
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26163791
67signal transduction involved in cell cycle checkpoint (GO:0072395)3.26073824
68water-soluble vitamin biosynthetic process (GO:0042364)3.25019759
69UTP biosynthetic process (GO:0006228)3.23420134
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23285504
71positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20884356
72protein localization to endoplasmic reticulum (GO:0070972)3.19267261
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15439609
74regulation of cellular respiration (GO:0043457)3.10802188
75* generation of precursor metabolites and energy (GO:0006091)3.07963407
76tricarboxylic acid cycle (GO:0006099)3.07610065
77intracellular protein transmembrane import (GO:0044743)3.07602252
78rRNA modification (GO:0000154)3.04736857
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04215437
80positive regulation of ligase activity (GO:0051351)3.03398136
81purine nucleoside monophosphate biosynthetic process (GO:0009127)3.01543390
82purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.01543390
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99722644
84regulation of cellular amine metabolic process (GO:0033238)2.96708537
85proteasome assembly (GO:0043248)2.95900658
86protein maturation by protein folding (GO:0022417)2.94886543
87exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93402202
88guanosine-containing compound biosynthetic process (GO:1901070)2.92568537
89cellular component biogenesis (GO:0044085)2.91140511
90UTP metabolic process (GO:0046051)2.90192367
91peptidyl-histidine modification (GO:0018202)2.88538327
92cellular respiration (GO:0045333)2.88314270
93ribosomal large subunit biogenesis (GO:0042273)2.88172601
94regulation of ubiquitin-protein transferase activity (GO:0051438)2.87976712
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86705742
96CENP-A containing nucleosome assembly (GO:0034080)2.85725883
97chromatin remodeling at centromere (GO:0031055)2.85239826
98pseudouridine synthesis (GO:0001522)2.84630855
99positive regulation of action potential (GO:0045760)2.81739475
100dopamine transport (GO:0015872)2.80848239
101spliceosomal snRNP assembly (GO:0000387)2.78925028
102purine ribonucleoside biosynthetic process (GO:0046129)2.78446937
103purine nucleoside biosynthetic process (GO:0042451)2.78446937
104C-terminal protein lipidation (GO:0006501)2.78335987
105cellular protein complex disassembly (GO:0043624)2.77827521
106translational elongation (GO:0006414)2.77784949
107ubiquinone biosynthetic process (GO:0006744)2.76874771
108quinone biosynthetic process (GO:1901663)2.76874771
109platelet dense granule organization (GO:0060155)2.76584462
110regulation of ligase activity (GO:0051340)2.74642995
111dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.73364286
112succinate metabolic process (GO:0006105)2.73182155
113viral life cycle (GO:0019058)2.72191546
114translation (GO:0006412)2.72179035
115calcium-mediated signaling using intracellular calcium source (GO:0035584)2.71778202
116branched-chain amino acid catabolic process (GO:0009083)2.69307114
117ribosomal small subunit assembly (GO:0000028)2.69041414
118nucleoside diphosphate phosphorylation (GO:0006165)2.68454325
119protein-cofactor linkage (GO:0018065)2.68019615
120negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.67562120
121cullin deneddylation (GO:0010388)2.67500686
122long-chain fatty acid biosynthetic process (GO:0042759)2.65470698
123ubiquinone metabolic process (GO:0006743)2.65077329
124establishment of integrated proviral latency (GO:0075713)2.62348428
125CTP biosynthetic process (GO:0006241)2.59502050
126CTP metabolic process (GO:0046036)2.59502050
127neurotransmitter uptake (GO:0001504)2.58329466
128mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.56718493
129regulation of cellular amino acid metabolic process (GO:0006521)2.54694752
130mitochondrion morphogenesis (GO:0070584)2.52723831
131detection of temperature stimulus (GO:0016048)2.50111369
132neuron cell-cell adhesion (GO:0007158)2.49533010
133establishment of viral latency (GO:0019043)2.47535033
134positive regulation of mitochondrial fission (GO:0090141)2.47444050
135cholesterol biosynthetic process (GO:0006695)2.44606677
136mannosylation (GO:0097502)2.43899679
137neuronal action potential propagation (GO:0019227)2.43515669
138aldehyde catabolic process (GO:0046185)2.41950461
139aggressive behavior (GO:0002118)2.41928577
140intracellular protein transmembrane transport (GO:0065002)2.41101028
141NADH metabolic process (GO:0006734)2.40741291
142ribonucleoside monophosphate biosynthetic process (GO:0009156)2.36935917
143protein deneddylation (GO:0000338)2.35926334
144ribonucleoside biosynthetic process (GO:0042455)2.33258225
145protein localization to cilium (GO:0061512)2.32696026
146neural nucleus development (GO:0048857)2.29719818
147mitochondrial ATP synthesis coupled proton transport (GO:0042776)10.2518421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02271167
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69558083
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.22520995
4EZH2_22144423_ChIP-Seq_EOC_Human3.21496412
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93961781
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.84556570
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67792950
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.66803924
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52075444
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47822274
11TAF15_26573619_Chip-Seq_HEK293_Human2.38077945
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37841055
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32947464
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29017253
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28971134
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28260386
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28185837
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24102734
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22838841
20* FOXP3_21729870_ChIP-Seq_TREG_Human2.18159308
21* GABP_19822575_ChIP-Seq_HepG2_Human2.17661399
22GBX2_23144817_ChIP-Seq_PC3_Human2.16844366
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.15252609
24VDR_22108803_ChIP-Seq_LS180_Human2.10168829
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07344047
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03988669
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00729033
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95000597
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94537341
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91849659
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91240356
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88869872
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.84729562
34* XRN2_22483619_ChIP-Seq_HELA_Human1.83684496
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81164695
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.79824278
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77216231
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76325519
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71936308
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70776559
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.69601111
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67094587
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66485620
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64263063
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.63536763
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62067604
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60254698
48* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56143977
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55747435
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54971166
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53323366
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52832284
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51701483
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.51579208
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45423089
56FUS_26573619_Chip-Seq_HEK293_Human1.45196292
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.44732487
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41713254
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.40878833
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40188803
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39849700
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38188438
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36565473
64EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36565473
65ER_23166858_ChIP-Seq_MCF-7_Human1.33725730
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33187668
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32987121
68P300_19829295_ChIP-Seq_ESCs_Human1.32608503
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31781675
70* DCP1A_22483619_ChIP-Seq_HELA_Human1.28518155
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27581705
72REST_21632747_ChIP-Seq_MESCs_Mouse1.27046549
73E2F7_22180533_ChIP-Seq_HELA_Human1.26952859
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26011111
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25121798
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.24965093
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21898908
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.20410465
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18865269
80* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18276245
81IGF1R_20145208_ChIP-Seq_DFB_Human1.17248218
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16459943
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16107783
84ELK1_19687146_ChIP-ChIP_HELA_Human1.14501945
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13588878
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13389900
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12461647
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.12433985
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12286316
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11740600
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11727187
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11631576
93CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10961602
94VDR_23849224_ChIP-Seq_CD4+_Human1.10299614
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10056013
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09253570
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08707928
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06193984
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05574104
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04737980
101* KDM5A_27292631_Chip-Seq_BREAST_Human1.04654071
102ELK1_22589737_ChIP-Seq_MCF10A_Human1.04593434
103HTT_18923047_ChIP-ChIP_STHdh_Human1.02765452
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.99719269
105E2F1_21310950_ChIP-Seq_MCF-7_Human0.99215579
106AR_21909140_ChIP-Seq_LNCAP_Human0.98807649
107* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97658543
108ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97538727
109RNF2_27304074_Chip-Seq_NSC_Mouse0.96668017
110* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96211937
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95898198
112TP53_22573176_ChIP-Seq_HFKS_Human0.95658376
113JUN_21703547_ChIP-Seq_K562_Human0.94709637
114TTF2_22483619_ChIP-Seq_HELA_Human0.94203500
115NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93168148
116PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92877864
117ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92621087
118FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92383687
119IRF1_19129219_ChIP-ChIP_H3396_Human0.91651761
120TFEB_21752829_ChIP-Seq_HELA_Human0.91600388
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.91378788
122* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91095239
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90154821
124* SOX2_19829295_ChIP-Seq_ESCs_Human0.87984801
125* NANOG_19829295_ChIP-Seq_ESCs_Human0.87984801
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87881820
127BP1_19119308_ChIP-ChIP_Hs578T_Human0.87373290
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86644562
129ZNF274_21170338_ChIP-Seq_K562_Hela0.86430559
130REST_19997604_ChIP-ChIP_NEURONS_Mouse0.86174915
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86105951
132PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85727339
133MYC_18940864_ChIP-ChIP_HL60_Human0.85099768
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84073754
135TAL1_26923725_Chip-Seq_HPCs_Mouse0.84041971
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.83613528
137ELF5_23300383_ChIP-Seq_T47D_Human0.83418575
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82116721
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81483724
140* NCOR_22424771_ChIP-Seq_293T_Human0.81313919
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81220324
142EWS_26573619_Chip-Seq_HEK293_Human0.80813940
143AR_20517297_ChIP-Seq_VCAP_Human0.79963458
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79871650
145TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76752009
146FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75817962
147FOXA1_25329375_ChIP-Seq_VCAP_Human0.75817962
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75801654
149TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75128320
150SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74599866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.06947773
2MP0001529_abnormal_vocalization3.86013313
3MP0009379_abnormal_foot_pigmentation3.69000448
4MP0002736_abnormal_nociception_after3.53265649
5MP0001968_abnormal_touch/_nociception3.03465556
6MP0006276_abnormal_autonomic_nervous2.93453887
7MP0002837_dystrophic_cardiac_calcinosis2.86937885
8MP0006036_abnormal_mitochondrial_physio2.53524225
9MP0005075_abnormal_melanosome_morpholog2.40995296
10MP0001905_abnormal_dopamine_level2.38807760
11MP0002735_abnormal_chemical_nociception2.29454462
12MP0002102_abnormal_ear_morphology2.26756594
13MP0002938_white_spotting2.24296868
14MP0008058_abnormal_DNA_repair2.23632542
15MP0002272_abnormal_nervous_system2.16149133
16MP0004142_abnormal_muscle_tone2.15062729
17MP0002734_abnormal_mechanical_nocicepti2.07295467
18MP0004270_analgesia2.06565039
19MP0002064_seizures2.04578467
20MP0001440_abnormal_grooming_behavior2.01709950
21MP0001970_abnormal_pain_threshold1.97611436
22MP0002733_abnormal_thermal_nociception1.96448194
23MP0009745_abnormal_behavioral_response1.92625562
24MP0002638_abnormal_pupillary_reflex1.92557339
25MP0010094_abnormal_chromosome_stability1.85765268
26MP0002095_abnormal_skin_pigmentation1.82903047
27MP0006035_abnormal_mitochondrial_morpho1.81956384
28MP0003718_maternal_effect1.80852988
29MP0009046_muscle_twitch1.79768644
30MP0003693_abnormal_embryo_hatching1.78145810
31MP0000751_myopathy1.77883526
32MP0003123_paternal_imprinting1.75659914
33MP0000015_abnormal_ear_pigmentation1.70370571
34MP0003635_abnormal_synaptic_transmissio1.69796932
35MP0001486_abnormal_startle_reflex1.68012367
36MP0005423_abnormal_somatic_nervous1.67354057
37MP0004215_abnormal_myocardial_fiber1.64670513
38MP0002876_abnormal_thyroid_physiology1.60321067
39MP0004043_abnormal_pH_regulation1.59522470
40MP0002572_abnormal_emotion/affect_behav1.58861797
41MP0003646_muscle_fatigue1.58716369
42MP0002067_abnormal_sensory_capabilities1.57954527
43MP0004957_abnormal_blastocyst_morpholog1.57424188
44MP0005645_abnormal_hypothalamus_physiol1.53076886
45MP0005386_behavior/neurological_phenoty1.52024017
46MP0004924_abnormal_behavior1.52024017
47MP0000920_abnormal_myelination1.51221559
48MP0008875_abnormal_xenobiotic_pharmacok1.50362777
49MP0004036_abnormal_muscle_relaxation1.49661894
50MP0003786_premature_aging1.47225868
51MP0001764_abnormal_homeostasis1.47143031
52MP0004742_abnormal_vestibular_system1.43234474
53MP0005171_absent_coat_pigmentation1.42559319
54MP0000749_muscle_degeneration1.40953778
55MP0001984_abnormal_olfaction1.40665975
56MP0004859_abnormal_synaptic_plasticity1.40368400
57MP0010386_abnormal_urinary_bladder1.39899365
58MP0006072_abnormal_retinal_apoptosis1.39531830
59MP0001485_abnormal_pinna_reflex1.38538153
60MP0003806_abnormal_nucleotide_metabolis1.34892626
61MP0003136_yellow_coat_color1.34156107
62MP0003195_calcinosis1.33346115
63MP0004145_abnormal_muscle_electrophysio1.31151640
64MP0001986_abnormal_taste_sensitivity1.30915952
65MP0008932_abnormal_embryonic_tissue1.30466864
66MP0002063_abnormal_learning/memory/cond1.29996944
67MP0001324_abnormal_eye_pigmentation1.28348385
68MP0005379_endocrine/exocrine_gland_phen1.27082821
69MP0002160_abnormal_reproductive_system1.26391416
70MP0001501_abnormal_sleep_pattern1.25861034
71MP0003011_delayed_dark_adaptation1.25521220
72MP0003137_abnormal_impulse_conducting1.25233812
73MP0003186_abnormal_redox_activity1.24836505
74MP0006292_abnormal_olfactory_placode1.23710529
75MP0005535_abnormal_body_temperature1.22716374
76MP0000372_irregular_coat_pigmentation1.18373595
77MP0008789_abnormal_olfactory_epithelium1.18234759
78MP0005174_abnormal_tail_pigmentation1.18047812
79MP0001188_hyperpigmentation1.17844491
80MP0005551_abnormal_eye_electrophysiolog1.17380294
81MP0003111_abnormal_nucleus_morphology1.16721724
82MP0005409_darkened_coat_color1.16202527
83MP0002163_abnormal_gland_morphology1.12351904
84MP0002229_neurodegeneration1.12319454
85MP0002184_abnormal_innervation1.11419720
86MP0000371_diluted_coat_color1.10722402
87MP0002332_abnormal_exercise_endurance1.10333755
88MP0003077_abnormal_cell_cycle1.07156356
89MP0001502_abnormal_circadian_rhythm1.05218171
90MP0001727_abnormal_embryo_implantation1.05189740
91MP0002822_catalepsy1.04054839
92MP0002557_abnormal_social/conspecific_i1.02523127
93MP0000778_abnormal_nervous_system1.01813090
94MP0005670_abnormal_white_adipose1.00898393
95MP0002066_abnormal_motor_capabilities/c1.00099575
96MP0003122_maternal_imprinting0.98908109
97MP0003329_amyloid_beta_deposits0.97147532
98MP0003634_abnormal_glial_cell0.96843483
99MP0008007_abnormal_cellular_replicative0.94880602
100MP0002972_abnormal_cardiac_muscle0.94568785
101MP0001963_abnormal_hearing_physiology0.94276540
102MP0005330_cardiomyopathy0.93938292
103MP0005646_abnormal_pituitary_gland0.93877890
104MP0005389_reproductive_system_phenotype0.93438207
105MP0000647_abnormal_sebaceous_gland0.93162836
106MP0000516_abnormal_urinary_system0.92442547
107MP0005367_renal/urinary_system_phenotyp0.92442547
108MP0003690_abnormal_glial_cell0.92056576
109MP0000358_abnormal_cell_content/0.89760797
110MP0002882_abnormal_neuron_morphology0.88171484
111MP0000230_abnormal_systemic_arterial0.88088034
112MP0002752_abnormal_somatic_nervous0.87314339
113MP0004084_abnormal_cardiac_muscle0.87309837
114MP0005253_abnormal_eye_physiology0.86899200
115MP0004484_altered_response_of0.86668079
116MP0005636_abnormal_mineral_homeostasis0.86573235
117MP0001664_abnormal_digestion0.86363502
118MP0008872_abnormal_physiological_respon0.85403307
119MP0005377_hearing/vestibular/ear_phenot0.84097632
120MP0003878_abnormal_ear_physiology0.84097632
121MP0004085_abnormal_heartbeat0.83405369
122MP0004147_increased_porphyrin_level0.83250242
123MP0003121_genomic_imprinting0.83062567
124MP0000747_muscle_weakness0.82899805
125MP0008877_abnormal_DNA_methylation0.82407966
126MP0009697_abnormal_copulation0.80227754
127MP0005085_abnormal_gallbladder_physiolo0.79274494
128MP0003787_abnormal_imprinting0.78742706
129MP0005620_abnormal_muscle_contractility0.78316112
130MP0004019_abnormal_vitamin_homeostasis0.77291513
131MP0002909_abnormal_adrenal_gland0.76901555
132MP0005332_abnormal_amino_acid0.76617572
133MP0005408_hypopigmentation0.76208632
134MP0000013_abnormal_adipose_tissue0.75596752
135MP0002090_abnormal_vision0.75363142
136MP0000026_abnormal_inner_ear0.75208821
137MP0005084_abnormal_gallbladder_morpholo0.74458271
138MP0005266_abnormal_metabolism0.73837884
139MP0000631_abnormal_neuroendocrine_gland0.73767556
140MP0002106_abnormal_muscle_physiology0.72358811
141MP0002751_abnormal_autonomic_nervous0.72286394
142MP0002234_abnormal_pharynx_morphology0.72150185
143MP0001186_pigmentation_phenotype0.71989145
144MP0001293_anophthalmia0.71967691
145MP0005360_urolithiasis0.71349559
146MP0005410_abnormal_fertilization0.70789098
147MP0000639_abnormal_adrenal_gland0.69711687
148MP0003567_abnormal_fetal_cardiomyocyte0.68497274
149MP0001919_abnormal_reproductive_system0.68473957
150MP0002075_abnormal_coat/hair_pigmentati0.68340541
151MP0002210_abnormal_sex_determination0.68330674
152MP0005365_abnormal_bile_salt0.67748704
153MP0005391_vision/eye_phenotype0.65065753
154MP0002653_abnormal_ependyma_morphology0.63594624
155MP0005187_abnormal_penis_morphology0.63078034
156MP0001929_abnormal_gametogenesis0.62027392

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.92083316
2Abnormal mitochondria in muscle tissue (HP:0008316)7.29236466
3Progressive macrocephaly (HP:0004481)6.69028447
4Mitochondrial inheritance (HP:0001427)6.64421652
5Acute encephalopathy (HP:0006846)6.59500392
6Increased CSF lactate (HP:0002490)5.67935738
7Hepatocellular necrosis (HP:0001404)5.67833213
8Hepatic necrosis (HP:0002605)5.14874358
9Cerebral edema (HP:0002181)4.76019681
10Increased hepatocellular lipid droplets (HP:0006565)4.65737755
11Lipid accumulation in hepatocytes (HP:0006561)4.30281798
12Myokymia (HP:0002411)4.26763302
13Leukodystrophy (HP:0002415)4.22500560
14Renal Fanconi syndrome (HP:0001994)4.16804207
15Respiratory failure (HP:0002878)4.15364721
16Increased serum pyruvate (HP:0003542)4.14981919
17Abnormality of glycolysis (HP:0004366)4.14981919
18Optic disc pallor (HP:0000543)4.11252017
19Decreased activity of mitochondrial respiratory chain (HP:0008972)4.01097094
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.01097094
213-Methylglutaconic aciduria (HP:0003535)3.97912493
22Exercise intolerance (HP:0003546)3.92319845
23Lactic acidosis (HP:0003128)3.90159959
24Increased intramyocellular lipid droplets (HP:0012240)3.89566909
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.85032472
26Pheochromocytoma (HP:0002666)3.62284089
27Neuroendocrine neoplasm (HP:0100634)3.60297477
28Increased muscle lipid content (HP:0009058)3.46171441
29Increased serum lactate (HP:0002151)3.43226845
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.39172659
31Sensory axonal neuropathy (HP:0003390)3.06878699
32Type I transferrin isoform profile (HP:0003642)2.99740378
33Abnormality of alanine metabolism (HP:0010916)2.89675439
34Hyperalaninemia (HP:0003348)2.89675439
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.89675439
36Abnormality of renal resorption (HP:0011038)2.87328408
37Degeneration of anterior horn cells (HP:0002398)2.86095675
38Abnormality of the anterior horn cell (HP:0006802)2.86095675
39Exertional dyspnea (HP:0002875)2.84114928
40X-linked dominant inheritance (HP:0001423)2.79959244
41Myotonia (HP:0002486)2.68925168
42Hyperglycinemia (HP:0002154)2.68606481
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.67976384
44Hypoplasia of the fovea (HP:0007750)2.67976384
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.63527658
46Abnormal protein N-linked glycosylation (HP:0012347)2.63527658
47Abnormal protein glycosylation (HP:0012346)2.63527658
48Abnormal glycosylation (HP:0012345)2.63527658
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61978778
50Respiratory difficulties (HP:0002880)2.58638576
51CNS demyelination (HP:0007305)2.58328496
52Patchy hypopigmentation of hair (HP:0011365)2.53862668
53Abnormality of cells of the erythroid lineage (HP:0012130)2.51143150
54Lethargy (HP:0001254)2.49324628
55Emotional lability (HP:0000712)2.46310750
56Reduced antithrombin III activity (HP:0001976)2.42203240
57Abnormality of serum amino acid levels (HP:0003112)2.38025447
58Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.37503018
59Glycosuria (HP:0003076)2.35849513
60Abnormality of urine glucose concentration (HP:0011016)2.35849513
61Focal motor seizures (HP:0011153)2.35514361
62Abnormality of the fovea (HP:0000493)2.32455500
63Muscle hypertrophy of the lower extremities (HP:0008968)2.25884498
64Hypothermia (HP:0002045)2.25401387
65Aplasia/Hypoplasia of the macula (HP:0008059)2.24885783
66Conjunctival hamartoma (HP:0100780)2.22006788
67Hyperphosphaturia (HP:0003109)2.17773644
68Palpitations (HP:0001962)2.15551220
69Abnormality of methionine metabolism (HP:0010901)2.15246345
70Adrenal hypoplasia (HP:0000835)2.10879922
71Calf muscle hypertrophy (HP:0008981)2.09537464
72Aplasia/Hypoplasia affecting the retina (HP:0008061)2.07796151
73Cerebral hemorrhage (HP:0001342)2.07709492
74Medial flaring of the eyebrow (HP:0010747)2.05039880
75Parakeratosis (HP:0001036)2.04425980
76White forelock (HP:0002211)2.00285768
77Methylmalonic aciduria (HP:0012120)2.00138665
78Opisthotonus (HP:0002179)1.99266742
79Microvesicular hepatic steatosis (HP:0001414)1.99205422
80Abnormal number of erythroid precursors (HP:0012131)1.97841333
81Retinal dysplasia (HP:0007973)1.96928289
82Progressive microcephaly (HP:0000253)1.95166198
83Muscle stiffness (HP:0003552)1.94099399
84Methylmalonic acidemia (HP:0002912)1.93499537
85Anxiety (HP:0000739)1.90067941
86Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89773083
87Molar tooth sign on MRI (HP:0002419)1.89547824
88Abnormality of midbrain morphology (HP:0002418)1.89547824
89Abnormal urine phosphate concentration (HP:0012599)1.87717387
90Vomiting (HP:0002013)1.87391569
91Abnormality of serine family amino acid metabolism (HP:0010894)1.86595327
92Abnormality of glycine metabolism (HP:0010895)1.86595327
93Congenital, generalized hypertrichosis (HP:0004540)1.85657841
94Macrocytic anemia (HP:0001972)1.85278730
95Dicarboxylic aciduria (HP:0003215)1.84908836
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84908836
97Hypoglycemic coma (HP:0001325)1.84382540
98Gait imbalance (HP:0002141)1.83696618
99Abnormal pupillary function (HP:0007686)1.83531073
100Hyperglycinuria (HP:0003108)1.81218015
101Blindness (HP:0000618)1.80347672
102Delayed CNS myelination (HP:0002188)1.79295345
103Neoplasm of the adrenal gland (HP:0100631)1.77856667
104Limb dystonia (HP:0002451)1.77260248
105Cerebral hypomyelination (HP:0006808)1.76652126
106Abnormal hair whorl (HP:0010721)1.76619454
107Congenital primary aphakia (HP:0007707)1.76219269
108Gliosis (HP:0002171)1.75058183
109Hypokinesia (HP:0002375)1.74645601
110Reticulocytopenia (HP:0001896)1.72859754
111Renal tubular dysfunction (HP:0000124)1.71457884
112Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70979195
113Congenital stationary night blindness (HP:0007642)1.69519894
114Metabolic acidosis (HP:0001942)1.68977000
115Nephrogenic diabetes insipidus (HP:0009806)1.68081114
116Poor suck (HP:0002033)1.67819091
117Degeneration of the lateral corticospinal tracts (HP:0002314)1.67413363
118Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67413363
119Ragged-red muscle fibers (HP:0003200)1.67398641
120Pancreatic cysts (HP:0001737)1.66926030
121Large for gestational age (HP:0001520)1.66691126
122Hyperventilation (HP:0002883)1.65723782
123Microretrognathia (HP:0000308)1.65326420
124Decreased electroretinogram (ERG) amplitude (HP:0000654)1.64662858
125Spastic paraparesis (HP:0002313)1.64377068
126Atonic seizures (HP:0010819)1.64326547
127Median cleft lip (HP:0000161)1.62246772
128Ketoacidosis (HP:0001993)1.62149896
129Genital tract atresia (HP:0001827)1.61450406
130Hypoplastic left heart (HP:0004383)1.61153822
131Abnormality of magnesium homeostasis (HP:0004921)1.61063323
132Vaginal atresia (HP:0000148)1.60212575
133Absence seizures (HP:0002121)1.59674209
134Epileptic encephalopathy (HP:0200134)1.57840296
135Delusions (HP:0000746)1.55136881
136Congenital ichthyosiform erythroderma (HP:0007431)1.55094820
137Neurofibrillary tangles (HP:0002185)1.54865987
138Sudden death (HP:0001699)1.53327773
139Progressive external ophthalmoplegia (HP:0000590)1.52651909
140Neoplasm of the peripheral nervous system (HP:0100007)1.49723584
141Generalized aminoaciduria (HP:0002909)1.48607191
142Abnormality of placental membranes (HP:0011409)1.48158038
143Amniotic constriction ring (HP:0009775)1.48158038
144Dialeptic seizures (HP:0011146)1.47014123
145Aplasia/hypoplasia of the uterus (HP:0008684)1.44074376
146Athetosis (HP:0002305)1.43267964
147Progressive inability to walk (HP:0002505)1.42575152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF3.58856537
2NME13.43379049
3NME23.32481953
4NEK13.21064952
5STK393.11948383
6VRK23.06592911
7STK162.96897978
8MAP3K122.83047693
9CASK2.73632691
10GRK52.69524295
11TRIM282.48506872
12OXSR12.37158228
13MYLK2.30004653
14LIMK12.28624902
15WEE12.13592088
16EIF2AK12.13087568
17MAP4K22.12088447
18MST42.08415858
19SRPK12.07948826
20MUSK2.02364767
21WNK41.96071515
22GRK71.92046663
23BCR1.82243847
24BMPR1B1.68934510
25CDK191.56373162
26PBK1.56309184
27ZAK1.51817015
28VRK11.50093727
29PIM21.49737378
30ERBB31.45516757
31TNIK1.45096945
32OBSCN1.44340112
33PLK31.40124628
34UHMK11.39816119
35PLK41.39646281
36BRAF1.38765282
37PHKG21.35913731
38PHKG11.35913731
39FRK1.34461414
40MAPKAPK51.33503499
41NTRK31.30426192
42MAP2K71.27426845
43BCKDK1.25775084
44CSNK1A1L1.25546222
45MAPK131.24930636
46ADRBK21.22846219
47PNCK1.19155061
48CDC71.17615254
49PLK11.13456965
50NUAK11.13340572
51ADRBK11.13199969
52CAMK2B1.12707941
53PLK21.10490228
54CAMK2D1.07837096
55LMTK21.05774056
56CAMK2A1.00277577
57DYRK20.99828676
58MARK10.99729577
59PKN10.98389050
60TTK0.97127962
61GRK10.97057853
62CAMK2G0.94461118
63CSNK1G30.93303891
64BMPR20.89270547
65DAPK10.89240630
66ILK0.87846959
67MINK10.85914123
68BUB10.85422604
69AURKB0.79742139
70WNK30.79731170
71ROCK20.79135158
72PRKCE0.78842867
73CDK140.77886487
74EPHA40.77828360
75MAPKAPK30.77672826
76TESK10.77001590
77TESK20.76110690
78PAK40.75671976
79BRSK10.75100853
80ABL20.73960496
81SCYL20.73119986
82PRKACA0.71749219
83MAP3K40.71029146
84TLK10.70657977
85PRKCI0.69259922
86CDK80.68740268
87FER0.67410007
88DAPK30.66497921
89PINK10.66239746
90EIF2AK30.65081761
91ATR0.64550057
92KDR0.64213038
93TSSK60.63404074
94CDK180.63044298
95MAPK150.62768593
96CDK150.61025947
97PDK40.60562934
98PDK30.60562934
99PRKCG0.59832626
100INSRR0.58868619
101CDK50.56901032
102EIF2AK20.56596336
103KSR20.55821981
104CDK11A0.54540761
105CSNK1G10.53947572
106MAP3K90.52479097
107MOS0.50749911
108CSNK1G20.49772745
109CSNK1A10.48812114
110MKNK10.48027906
111MAP3K20.47236662
112NEK60.46680661
113AURKA0.44397244
114CHEK20.44229183
115TNK20.44010098
116PIK3CA0.43963022
117ERBB40.43755560
118PAK30.43628246
119ACVR1B0.42384318
120SGK4940.42004011
121SGK2230.42004011
122BRSK20.40532517
123PDK20.39873513
124AKT20.39046270
125RAF10.38244656
126EPHA20.37872832
127MKNK20.37590009
128STK240.37192674
129RPS6KA50.37111290
130NTRK10.36586713
131MAPK40.36065062
132RPS6KA40.35767565
133CCNB10.35739397
134IRAK10.35494796
135PAK10.35237856
136CSNK2A10.34929711
137NTRK20.34618134
138PRKG10.34387604
139MAP2K20.33920533
140CSNK2A20.33842032
141PRKCA0.33790505

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.79737249
2Parkinsons disease_Homo sapiens_hsa050125.88506213
3Alzheimers disease_Homo sapiens_hsa050104.43462883
4Huntingtons disease_Homo sapiens_hsa050164.05609541
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.66408653
6Ribosome_Homo sapiens_hsa030103.29103046
7Cardiac muscle contraction_Homo sapiens_hsa042603.19084398
8Proteasome_Homo sapiens_hsa030502.59557117
9Protein export_Homo sapiens_hsa030602.58409563
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27788038
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22979213
12Fatty acid elongation_Homo sapiens_hsa000622.21489402
13Collecting duct acid secretion_Homo sapiens_hsa049661.91963401
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88298123
15Mismatch repair_Homo sapiens_hsa034301.84874403
16Sulfur metabolism_Homo sapiens_hsa009201.80614207
17Homologous recombination_Homo sapiens_hsa034401.80169206
18DNA replication_Homo sapiens_hsa030301.78093980
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61352392
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50379841
21Propanoate metabolism_Homo sapiens_hsa006401.44381783
22RNA polymerase_Homo sapiens_hsa030201.42097142
23Pyruvate metabolism_Homo sapiens_hsa006201.40575762
24Nucleotide excision repair_Homo sapiens_hsa034201.34278522
25Base excision repair_Homo sapiens_hsa034101.29117651
26Vibrio cholerae infection_Homo sapiens_hsa051101.29099172
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28345190
28One carbon pool by folate_Homo sapiens_hsa006701.22378407
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20443733
30Nicotine addiction_Homo sapiens_hsa050331.15438699
31Spliceosome_Homo sapiens_hsa030401.11425034
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10675527
33Synaptic vesicle cycle_Homo sapiens_hsa047211.09603455
34Butanoate metabolism_Homo sapiens_hsa006501.09343690
35Fanconi anemia pathway_Homo sapiens_hsa034601.08098571
36Steroid biosynthesis_Homo sapiens_hsa001001.02780840
37RNA degradation_Homo sapiens_hsa030181.02061172
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.01856228
39RNA transport_Homo sapiens_hsa030130.95976069
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95721179
41Non-homologous end-joining_Homo sapiens_hsa034500.95442209
42Vitamin B6 metabolism_Homo sapiens_hsa007500.94951638
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94058163
44* Metabolic pathways_Homo sapiens_hsa011000.92181871
45Carbon metabolism_Homo sapiens_hsa012000.82739851
46GABAergic synapse_Homo sapiens_hsa047270.82299070
47Ether lipid metabolism_Homo sapiens_hsa005650.82213310
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81332540
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81094033
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80481139
51Peroxisome_Homo sapiens_hsa041460.80207882
52Serotonergic synapse_Homo sapiens_hsa047260.79232118
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.77846940
54Tryptophan metabolism_Homo sapiens_hsa003800.77531965
55Glutathione metabolism_Homo sapiens_hsa004800.76058011
56N-Glycan biosynthesis_Homo sapiens_hsa005100.75243032
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72990109
58Pyrimidine metabolism_Homo sapiens_hsa002400.72103524
59Rheumatoid arthritis_Homo sapiens_hsa053230.71504631
60Fatty acid metabolism_Homo sapiens_hsa012120.68294713
61Taste transduction_Homo sapiens_hsa047420.65851318
62Tyrosine metabolism_Homo sapiens_hsa003500.65632252
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65300167
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63685222
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63301534
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62244934
67Morphine addiction_Homo sapiens_hsa050320.59483209
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.59088537
69Linoleic acid metabolism_Homo sapiens_hsa005910.57562356
70Arachidonic acid metabolism_Homo sapiens_hsa005900.55560203
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54815187
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53901095
73Fatty acid degradation_Homo sapiens_hsa000710.53199559
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53120486
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52716710
76Phenylalanine metabolism_Homo sapiens_hsa003600.52030991
77Arginine and proline metabolism_Homo sapiens_hsa003300.51947001
78Retinol metabolism_Homo sapiens_hsa008300.51610150
79Phototransduction_Homo sapiens_hsa047440.50962508
80Caffeine metabolism_Homo sapiens_hsa002320.50948776
81Purine metabolism_Homo sapiens_hsa002300.50242924
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49949411
83Glutamatergic synapse_Homo sapiens_hsa047240.49542353
84Arginine biosynthesis_Homo sapiens_hsa002200.48086795
85Histidine metabolism_Homo sapiens_hsa003400.46266790
86Regulation of autophagy_Homo sapiens_hsa041400.46242707
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.45598174
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43706274
89Circadian entrainment_Homo sapiens_hsa047130.43380306
90Fat digestion and absorption_Homo sapiens_hsa049750.42273456
91Phagosome_Homo sapiens_hsa041450.41647263
92Sulfur relay system_Homo sapiens_hsa041220.40546016
93Nitrogen metabolism_Homo sapiens_hsa009100.38376771
94Selenocompound metabolism_Homo sapiens_hsa004500.37843918
95Cell cycle_Homo sapiens_hsa041100.37661196
96Oocyte meiosis_Homo sapiens_hsa041140.37552810
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36182012
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35307567
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33876164
100Folate biosynthesis_Homo sapiens_hsa007900.32583233
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32450518
102Chemical carcinogenesis_Homo sapiens_hsa052040.31051632
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30247067
104Dopaminergic synapse_Homo sapiens_hsa047280.30148256
105Galactose metabolism_Homo sapiens_hsa000520.29555242
106Calcium signaling pathway_Homo sapiens_hsa040200.28447766
107Fructose and mannose metabolism_Homo sapiens_hsa000510.28192713
108Cholinergic synapse_Homo sapiens_hsa047250.26177006
109Sphingolipid metabolism_Homo sapiens_hsa006000.26044495
110Olfactory transduction_Homo sapiens_hsa047400.25719816
111Renin secretion_Homo sapiens_hsa049240.25434239
112Amphetamine addiction_Homo sapiens_hsa050310.25310123
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.25048286
114Long-term depression_Homo sapiens_hsa047300.24228702
115Salivary secretion_Homo sapiens_hsa049700.23432822
116Insulin secretion_Homo sapiens_hsa049110.22194035
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21641743
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20387748
119beta-Alanine metabolism_Homo sapiens_hsa004100.20367848
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19991365
121Cocaine addiction_Homo sapiens_hsa050300.19776760
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.16915789
123Autoimmune thyroid disease_Homo sapiens_hsa053200.16914106
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.13878988
125Gastric acid secretion_Homo sapiens_hsa049710.13815644
126Mineral absorption_Homo sapiens_hsa049780.12830288
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10098566
128Alcoholism_Homo sapiens_hsa050340.10054006
129Pentose phosphate pathway_Homo sapiens_hsa000300.10033830
130Basal transcription factors_Homo sapiens_hsa030220.09542226
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.08672840
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.08096030
133Biosynthesis of amino acids_Homo sapiens_hsa012300.07383147
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07353738
135Long-term potentiation_Homo sapiens_hsa047200.07302682
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07196902
137Dilated cardiomyopathy_Homo sapiens_hsa054140.07172803

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