NDUFC2-KCTD14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring NDUFC2 (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa) and KCTD14 (potassium channel tetramerisation domain containing 14) genes on chromosome 11. The read-through transcripts share sequence identity with the upstream gene product and one variant has a frameshifted C-terminal region derived from the downstream gene exons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.24926641
2ATP synthesis coupled proton transport (GO:0015986)7.14558434
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.14558434
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.57582428
5chaperone-mediated protein transport (GO:0072321)6.50099690
6* respiratory electron transport chain (GO:0022904)6.07076826
7establishment of protein localization to mitochondrial membrane (GO:0090151)6.06810168
8* electron transport chain (GO:0022900)5.95651114
9protein complex biogenesis (GO:0070271)5.41612853
10viral transcription (GO:0019083)5.27478904
11mitochondrial respiratory chain complex assembly (GO:0033108)5.23302563
12translational termination (GO:0006415)5.17918611
13proteasome assembly (GO:0043248)5.07294328
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.02955074
15mitochondrial respiratory chain complex I assembly (GO:0032981)5.02955074
16NADH dehydrogenase complex assembly (GO:0010257)5.02955074
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.95471267
18cotranslational protein targeting to membrane (GO:0006613)4.94895879
19protein targeting to ER (GO:0045047)4.86897809
20ribosomal small subunit assembly (GO:0000028)4.81707906
21ribosomal small subunit biogenesis (GO:0042274)4.65859966
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.65549153
23maturation of SSU-rRNA (GO:0030490)4.61324071
24protein localization to endoplasmic reticulum (GO:0070972)4.58735680
25protein neddylation (GO:0045116)4.53669188
26translational elongation (GO:0006414)4.37008992
27respiratory chain complex IV assembly (GO:0008535)4.35553454
28transcription elongation from RNA polymerase III promoter (GO:0006385)4.26789681
29termination of RNA polymerase III transcription (GO:0006386)4.26789681
30ribosomal large subunit biogenesis (GO:0042273)4.25442919
31regulation of mitochondrial translation (GO:0070129)4.24794583
32cytochrome complex assembly (GO:0017004)4.14613133
33translation (GO:0006412)4.10057154
34hydrogen ion transmembrane transport (GO:1902600)3.99152682
35translational initiation (GO:0006413)3.95899809
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.95064708
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.94405596
38ATP biosynthetic process (GO:0006754)3.93362838
39cellular protein complex disassembly (GO:0043624)3.93330427
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.88750680
41viral life cycle (GO:0019058)3.88384658
42rRNA modification (GO:0000154)3.83997887
43protein targeting to mitochondrion (GO:0006626)3.82370331
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.79462981
45purine nucleoside triphosphate biosynthetic process (GO:0009145)3.72044120
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.70633798
47pseudouridine synthesis (GO:0001522)3.70009165
48establishment of protein localization to mitochondrion (GO:0072655)3.63296450
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60738842
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59032606
51chromatin remodeling at centromere (GO:0031055)3.58847262
52negative regulation of ligase activity (GO:0051352)3.58475419
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.58475419
54spliceosomal snRNP assembly (GO:0000387)3.57023805
55protein localization to mitochondrion (GO:0070585)3.55960464
56regulation of cellular amino acid metabolic process (GO:0006521)3.54242281
57cellular component biogenesis (GO:0044085)3.53871964
58CENP-A containing nucleosome assembly (GO:0034080)3.52710463
59proton transport (GO:0015992)3.52311807
60inner mitochondrial membrane organization (GO:0007007)3.44504070
61hydrogen transport (GO:0006818)3.44457972
62protein-cofactor linkage (GO:0018065)3.42824155
63intracellular protein transmembrane import (GO:0044743)3.39821511
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39801153
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37991778
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37300883
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37300883
68water-soluble vitamin biosynthetic process (GO:0042364)3.36406043
69DNA deamination (GO:0045006)3.31842712
70ribonucleoside triphosphate biosynthetic process (GO:0009201)3.30960752
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30765717
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30765717
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30765717
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28545000
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28545000
76protein complex disassembly (GO:0043241)3.24922410
77rRNA processing (GO:0006364)3.19065859
78oxidative phosphorylation (GO:0006119)3.19047958
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16273553
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.16273553
81protein targeting to membrane (GO:0006612)3.15977451
82mitochondrial transport (GO:0006839)3.15201080
83signal transduction involved in cell cycle checkpoint (GO:0072395)3.15056968
84macromolecular complex disassembly (GO:0032984)3.14524895
85cullin deneddylation (GO:0010388)3.13261440
86positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09474784
87DNA damage response, detection of DNA damage (GO:0042769)3.08827808
88ribonucleoprotein complex biogenesis (GO:0022613)3.07843974
89rRNA metabolic process (GO:0016072)3.07269886
90nucleoside triphosphate biosynthetic process (GO:0009142)3.02178564
91nuclear-transcribed mRNA catabolic process (GO:0000956)3.02026683
92spliceosomal complex assembly (GO:0000245)3.00241276
93GTP biosynthetic process (GO:0006183)2.98658505
94histone exchange (GO:0043486)2.97363868
957-methylguanosine mRNA capping (GO:0006370)2.97330371
96positive regulation of ligase activity (GO:0051351)2.94097118
97kinetochore assembly (GO:0051382)2.93804233
98rRNA methylation (GO:0031167)2.91798144
99pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.91216147
1007-methylguanosine RNA capping (GO:0009452)2.90960892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.49992588
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.95273175
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.59934484
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.00180936
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.50153097
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.48087962
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.30377489
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.21869948
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.20207949
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.07825752
11ELK1_19687146_ChIP-ChIP_HELA_Human2.99824570
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.80364520
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.80225266
14VDR_23849224_ChIP-Seq_CD4+_Human2.62854020
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47608725
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32511120
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24870177
18FOXP3_21729870_ChIP-Seq_TREG_Human2.24164519
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21225326
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.19809760
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16218195
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05977702
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04592624
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97488802
25MYC_18940864_ChIP-ChIP_HL60_Human1.92940202
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90995606
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87414497
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86480150
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85133282
30TTF2_22483619_ChIP-Seq_HELA_Human1.83845064
31VDR_22108803_ChIP-Seq_LS180_Human1.80812052
32ZNF274_21170338_ChIP-Seq_K562_Hela1.79759166
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78501262
34DCP1A_22483619_ChIP-Seq_HELA_Human1.76825890
35EWS_26573619_Chip-Seq_HEK293_Human1.74812009
36XRN2_22483619_ChIP-Seq_HELA_Human1.73508593
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73023236
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66661150
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63447511
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.62818492
41E2F7_22180533_ChIP-Seq_HELA_Human1.62373054
42FUS_26573619_Chip-Seq_HEK293_Human1.60665620
43GABP_19822575_ChIP-Seq_HepG2_Human1.57884203
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53646920
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48210776
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46818477
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.43047824
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41297420
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40004166
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38283558
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35103355
52ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29503381
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27867369
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26824961
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.25915307
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21592728
57IGF1R_20145208_ChIP-Seq_DFB_Human1.18391598
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.16181831
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15146807
60P300_19829295_ChIP-Seq_ESCs_Human1.13972715
61TAF15_26573619_Chip-Seq_HEK293_Human1.09017767
62TP53_22573176_ChIP-Seq_HFKS_Human1.08800008
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07966124
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.07567529
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06692942
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03575789
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02693309
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02176521
69E2F1_21310950_ChIP-Seq_MCF-7_Human0.99132833
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98667394
71PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96866498
72BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96363616
73ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95985633
74CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94490889
75FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93189823
76FOXA1_25329375_ChIP-Seq_VCAP_Human0.93189823
77SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92605852
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90882421
79IRF1_19129219_ChIP-ChIP_H3396_Human0.89700167
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88280681
81SOX2_19829295_ChIP-Seq_ESCs_Human0.88005503
82NANOG_19829295_ChIP-Seq_ESCs_Human0.88005503
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86703748
84AR_20517297_ChIP-Seq_VCAP_Human0.83291709
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83046404
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81305700
87TP63_19390658_ChIP-ChIP_HaCaT_Human0.80124319
88HTT_18923047_ChIP-ChIP_STHdh_Human0.78186728
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77299872
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.76639077
91ER_23166858_ChIP-Seq_MCF-7_Human0.76496549
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76197495
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75527268
94FOXM1_23109430_ChIP-Seq_U2OS_Human0.75471493
95SALL1_21062744_ChIP-ChIP_HESCs_Human0.75242995
96NCOR_22424771_ChIP-Seq_293T_Human0.75017648
97KDM5A_27292631_Chip-Seq_BREAST_Human0.74855273
98ERG_20517297_ChIP-Seq_VCAP_Human0.74387086
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74228670
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73249675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.06242893
2MP0003806_abnormal_nucleotide_metabolis3.48809906
3MP0006292_abnormal_olfactory_placode3.26057494
4MP0000372_irregular_coat_pigmentation3.16926245
5MP0002938_white_spotting2.85530261
6MP0008058_abnormal_DNA_repair2.76332041
7MP0003136_yellow_coat_color2.71506813
8MP0001529_abnormal_vocalization2.50764403
9MP0006072_abnormal_retinal_apoptosis2.33275934
10MP0003186_abnormal_redox_activity2.26807935
11MP0003718_maternal_effect2.25292829
12MP0002102_abnormal_ear_morphology2.05903421
13MP0002277_abnormal_respiratory_mucosa1.91677656
14MP0003693_abnormal_embryo_hatching1.87302913
15MP0002736_abnormal_nociception_after1.86965661
16MP0010094_abnormal_chromosome_stability1.84906779
17MP0006036_abnormal_mitochondrial_physio1.82874680
18MP0002638_abnormal_pupillary_reflex1.82838280
19MP0004957_abnormal_blastocyst_morpholog1.79753595
20MP0005408_hypopigmentation1.79519535
21MP0003880_abnormal_central_pattern1.78174254
22MP0009697_abnormal_copulation1.77999638
23MP0008877_abnormal_DNA_methylation1.75628031
24MP0005084_abnormal_gallbladder_morpholo1.72064890
25MP0003011_delayed_dark_adaptation1.68651287
26MP0003941_abnormal_skin_development1.67365567
27MP0004142_abnormal_muscle_tone1.65110855
28MP0002837_dystrophic_cardiac_calcinosis1.57656460
29MP0001485_abnormal_pinna_reflex1.55571730
30MP0001293_anophthalmia1.49165633
31MP0008789_abnormal_olfactory_epithelium1.48641075
32MP0001984_abnormal_olfaction1.46773479
33MP0003786_premature_aging1.46500539
34MP0008875_abnormal_xenobiotic_pharmacok1.45720000
35MP0005646_abnormal_pituitary_gland1.42749461
36MP0005551_abnormal_eye_electrophysiolog1.42025440
37MP0000631_abnormal_neuroendocrine_gland1.41674126
38MP0003195_calcinosis1.41273771
39MP0003077_abnormal_cell_cycle1.40676486
40MP0009046_muscle_twitch1.40640045
41MP0001968_abnormal_touch/_nociception1.39631058
42MP0006035_abnormal_mitochondrial_morpho1.38760841
43MP0001905_abnormal_dopamine_level1.38560979
44MP0002822_catalepsy1.35953660
45MP0005253_abnormal_eye_physiology1.33141127
46MP0002095_abnormal_skin_pigmentation1.30928034
47MP0005075_abnormal_melanosome_morpholog1.29643335
48MP0008872_abnormal_physiological_respon1.29342550
49MP0006276_abnormal_autonomic_nervous1.28549034
50MP0003121_genomic_imprinting1.24827539
51MP0008995_early_reproductive_senescence1.22461457
52MP0005645_abnormal_hypothalamus_physiol1.20155595
53MP0008932_abnormal_embryonic_tissue1.18736369
54MP0002160_abnormal_reproductive_system1.18633467
55MP0003111_abnormal_nucleus_morphology1.17679087
56MP0001188_hyperpigmentation1.12688814
57MP0003567_abnormal_fetal_cardiomyocyte1.09418997
58MP0004133_heterotaxia1.07484159
59MP0005174_abnormal_tail_pigmentation1.04594387
60MP0003123_paternal_imprinting1.03899702
61MP0009745_abnormal_behavioral_response1.02601934
62MP0004147_increased_porphyrin_level1.02484706
63MP0005171_absent_coat_pigmentation1.02158163
64MP0001986_abnormal_taste_sensitivity1.01531937
65MP0003878_abnormal_ear_physiology1.01334091
66MP0005377_hearing/vestibular/ear_phenot1.01334091
67MP0002272_abnormal_nervous_system1.00945193
68MP0000049_abnormal_middle_ear0.99163340
69MP0001764_abnormal_homeostasis0.99107014
70MP0010030_abnormal_orbit_morphology0.98456688
71MP0005389_reproductive_system_phenotype0.98260679
72MP0004885_abnormal_endolymph0.97545926
73MP0002210_abnormal_sex_determination0.94751527
74MP0002163_abnormal_gland_morphology0.93296332
75MP0002751_abnormal_autonomic_nervous0.91232065
76MP0002653_abnormal_ependyma_morphology0.90418380
77MP0005394_taste/olfaction_phenotype0.89580198
78MP0005499_abnormal_olfactory_system0.89580198
79MP0008007_abnormal_cellular_replicative0.89309842
80MP0003938_abnormal_ear_development0.87255943
81MP0002090_abnormal_vision0.85465236
82MP0000569_abnormal_digit_pigmentation0.85331090
83MP0002876_abnormal_thyroid_physiology0.85279785
84MP0003937_abnormal_limbs/digits/tail_de0.82038894
85MP0002282_abnormal_trachea_morphology0.81506766
86MP0003122_maternal_imprinting0.81319998
87MP0005410_abnormal_fertilization0.80714886
88MP0005332_abnormal_amino_acid0.79166637
89MP0001929_abnormal_gametogenesis0.79075570
90MP0001286_abnormal_eye_development0.76865799
91MP0000653_abnormal_sex_gland0.76354398
92MP0005195_abnormal_posterior_eye0.76319058
93MP0001486_abnormal_startle_reflex0.75840352
94MP0010386_abnormal_urinary_bladder0.75026873
95MP0002752_abnormal_somatic_nervous0.73341693
96MP0002735_abnormal_chemical_nociception0.73225845
97MP0005636_abnormal_mineral_homeostasis0.73101163
98MP0001145_abnormal_male_reproductive0.72583341
99MP0000026_abnormal_inner_ear0.70246700
100MP0003315_abnormal_perineum_morphology0.69413382

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.45340188
2Abnormal mitochondria in muscle tissue (HP:0008316)5.76670930
3Mitochondrial inheritance (HP:0001427)5.63170835
4Acute encephalopathy (HP:0006846)5.50805232
5Progressive macrocephaly (HP:0004481)5.42520598
6Increased CSF lactate (HP:0002490)4.98274108
7Increased hepatocellular lipid droplets (HP:0006565)4.91699487
8Hepatocellular necrosis (HP:0001404)4.71578990
9Lipid accumulation in hepatocytes (HP:0006561)4.44067038
10Hepatic necrosis (HP:0002605)4.28288594
11Renal Fanconi syndrome (HP:0001994)4.20316269
12Cerebral edema (HP:0002181)4.10612457
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.66610307
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.66610307
153-Methylglutaconic aciduria (HP:0003535)3.53390459
16Abnormality of cells of the erythroid lineage (HP:0012130)3.52187266
17Abnormal number of erythroid precursors (HP:0012131)3.49606781
18Macrocytic anemia (HP:0001972)3.41859687
19Increased intramyocellular lipid droplets (HP:0012240)3.33962530
20Exertional dyspnea (HP:0002875)3.24146424
21Congenital, generalized hypertrichosis (HP:0004540)3.18989194
22Respiratory failure (HP:0002878)3.16182379
23Lactic acidosis (HP:0003128)3.05287247
24Reticulocytopenia (HP:0001896)3.04919319
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.04303289
26Leukodystrophy (HP:0002415)3.04129371
27Increased serum lactate (HP:0002151)3.01891994
28Optic disc pallor (HP:0000543)2.95165291
29Pancreatic cysts (HP:0001737)2.89196562
30Pancreatic fibrosis (HP:0100732)2.86154391
31Abnormality of renal resorption (HP:0011038)2.85170576
32Exercise intolerance (HP:0003546)2.81257970
33Methylmalonic acidemia (HP:0002912)2.76660377
34Abnormality of midbrain morphology (HP:0002418)2.75269620
35Molar tooth sign on MRI (HP:0002419)2.75269620
36Increased muscle lipid content (HP:0009058)2.70233760
37Respiratory difficulties (HP:0002880)2.62168283
38True hermaphroditism (HP:0010459)2.58533013
39Lethargy (HP:0001254)2.51773284
40Aplastic anemia (HP:0001915)2.51367287
41Type I transferrin isoform profile (HP:0003642)2.48370408
42Methylmalonic aciduria (HP:0012120)2.41351565
43Oral leukoplakia (HP:0002745)2.40129270
44Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39827019
45Septo-optic dysplasia (HP:0100842)2.38218105
46Abnormality of urine glucose concentration (HP:0011016)2.35534890
47Glycosuria (HP:0003076)2.35534890
48Hypothermia (HP:0002045)2.32084738
49Pallor (HP:0000980)2.28809902
50Nephronophthisis (HP:0000090)2.25856159
51Hyperalaninemia (HP:0003348)2.17202280
52Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17202280
53Abnormality of alanine metabolism (HP:0010916)2.17202280
54Colon cancer (HP:0003003)2.15138662
55Hyperphosphaturia (HP:0003109)2.14256399
56CNS demyelination (HP:0007305)2.14197909
57X-linked dominant inheritance (HP:0001423)2.13153976
58Generalized aminoaciduria (HP:0002909)2.12898098
59Medial flaring of the eyebrow (HP:0010747)2.11155600
60Abnormality of methionine metabolism (HP:0010901)2.04953992
61Abnormality of serum amino acid levels (HP:0003112)2.00017931
62Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99904751
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99716730
64Abnormal protein N-linked glycosylation (HP:0012347)1.99716730
65Abnormal protein glycosylation (HP:0012346)1.99716730
66Abnormal glycosylation (HP:0012345)1.99716730
67Abnormality of placental membranes (HP:0011409)1.98445437
68Amniotic constriction ring (HP:0009775)1.98445437
69Meckel diverticulum (HP:0002245)1.98153992
70Abnormality of the labia minora (HP:0012880)1.97662687
71Absent thumb (HP:0009777)1.96928373
72Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96005220
73Congenital stationary night blindness (HP:0007642)1.93832905
74Abnormality of the ileum (HP:0001549)1.90710490
75Hyperglycinemia (HP:0002154)1.90471768
76Sclerocornea (HP:0000647)1.87105639
77Megaloblastic anemia (HP:0001889)1.85606609
78Aplasia/Hypoplasia of the uvula (HP:0010293)1.85215953
79Pendular nystagmus (HP:0012043)1.80921860
80Blindness (HP:0000618)1.80698456
81Concave nail (HP:0001598)1.76610371
82Increased serum pyruvate (HP:0003542)1.75877215
83Pancytopenia (HP:0001876)1.74452148
84Abnormality of the renal medulla (HP:0100957)1.74219555
85Degeneration of anterior horn cells (HP:0002398)1.72620595
86Abnormality of the anterior horn cell (HP:0006802)1.72620595
87Male pseudohermaphroditism (HP:0000037)1.71466775
88Emotional lability (HP:0000712)1.70399545
89Congenital primary aphakia (HP:0007707)1.69702671
90Sparse eyelashes (HP:0000653)1.69094281
91Absent septum pellucidum (HP:0001331)1.67791284
92Gait imbalance (HP:0002141)1.67226806
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.62696288
94Reduced antithrombin III activity (HP:0001976)1.62530391
95Abnormality of vitamin B metabolism (HP:0004340)1.60977553
96Myokymia (HP:0002411)1.59732259
97Aplasia/hypoplasia of the uterus (HP:0008684)1.59307368
98Triphalangeal thumb (HP:0001199)1.59284303
99Abnormality of the preputium (HP:0100587)1.58824831
100Stenosis of the external auditory canal (HP:0000402)1.57865361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.49515439
2BUB13.46055508
3MST42.78931759
4VRK12.58073212
5STK162.53184688
6CDC72.51482628
7PBK2.51243431
8ZAK2.49849973
9NME12.47168370
10SRPK12.15259371
11WNK32.12828165
12TLK12.12200486
13BMPR1B1.97568924
14NUAK11.96478524
15MAP3K121.84257202
16MAP4K21.76355353
17NME21.73669660
18EIF2AK31.72185048
19DYRK21.72065968
20PLK31.68357059
21TNIK1.62906150
22PLK41.61994644
23PDK21.54488238
24WEE11.52972890
25BCKDK1.52860269
26EIF2AK11.50614111
27ADRBK21.47678514
28TRIM281.44927528
29GRK11.41596642
30NEK11.40047200
31MKNK21.35595174
32TAF11.33901577
33TAOK31.23518328
34FRK1.20133565
35INSRR1.17425466
36TTK1.14266486
37PNCK1.13469882
38OXSR11.13394751
39MKNK11.12500974
40CASK1.10255651
41PLK11.07295880
42CSNK1G10.96941999
43CSNK1G20.91016137
44TSSK60.89187502
45CSNK1G30.88151488
46BRSK20.87633458
47AURKB0.83456638
48PLK20.83297795
49CSNK2A20.77618469
50STK390.77428920
51PAK30.77199381
52MAP2K70.76331230
53WNK40.74582617
54PRKCG0.72994200
55PINK10.72891783
56DYRK30.71653108
57MYLK0.71156869
58CSNK2A10.70856634
59ABL20.69662874
60ATR0.67428601
61CHEK20.66943110
62MAPK130.66863523
63RPS6KA50.66158011
64STK40.65483391
65MAP3K40.61620123
66AURKA0.60651230
67STK38L0.59858993
68EIF2AK20.59691566
69LIMK10.59242639
70BCR0.58755516
71CDK190.55963224
72MUSK0.55324385
73MINK10.53650037
74ADRBK10.52962079
75CDK80.52195985
76CSNK1A1L0.51697945
77CSNK1E0.50310652
78PRKCE0.49049519
79CCNB10.48726052
80ILK0.48571626
81PASK0.48426586
82CSNK1A10.48177806
83TIE10.46824904
84CDK30.45090573
85NEK20.45009963
86ERBB30.43383715
87KDR0.42707041
88PRKCI0.42293029
89ATM0.41792136
90DAPK10.41601418
91MAPK150.41367351
92TEC0.38082023
93ACVR1B0.38053438
94DAPK30.37109573
95OBSCN0.36762736
96PRKACA0.36510173
97BRSK10.35374060
98RPS6KA40.34380110
99PHKG20.33754255
100PHKG10.33754255

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.03957729
2Ribosome_Homo sapiens_hsa030104.77326817
3Parkinsons disease_Homo sapiens_hsa050124.24980864
4Proteasome_Homo sapiens_hsa030504.22205051
5Protein export_Homo sapiens_hsa030603.37204959
6Huntingtons disease_Homo sapiens_hsa050163.01357813
7RNA polymerase_Homo sapiens_hsa030202.97381530
8Alzheimers disease_Homo sapiens_hsa050102.87989174
9* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.56695856
10Homologous recombination_Homo sapiens_hsa034402.33347729
11Mismatch repair_Homo sapiens_hsa034302.26918820
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13778680
13DNA replication_Homo sapiens_hsa030302.13121488
14Cardiac muscle contraction_Homo sapiens_hsa042602.11682603
15Spliceosome_Homo sapiens_hsa030401.77983421
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72127139
17Nucleotide excision repair_Homo sapiens_hsa034201.66567324
18Basal transcription factors_Homo sapiens_hsa030221.64100436
19Pyrimidine metabolism_Homo sapiens_hsa002401.53676793
20RNA degradation_Homo sapiens_hsa030181.53671083
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46385326
22One carbon pool by folate_Homo sapiens_hsa006701.41519469
23Base excision repair_Homo sapiens_hsa034101.40475157
24Fanconi anemia pathway_Homo sapiens_hsa034601.38820087
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38434224
26RNA transport_Homo sapiens_hsa030131.25583254
27Propanoate metabolism_Homo sapiens_hsa006401.14801494
28Purine metabolism_Homo sapiens_hsa002301.13555790
29Folate biosynthesis_Homo sapiens_hsa007901.11294852
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04841616
31Glutathione metabolism_Homo sapiens_hsa004801.01714168
32Non-homologous end-joining_Homo sapiens_hsa034501.00752702
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96796640
34Phototransduction_Homo sapiens_hsa047440.96474762
35Pyruvate metabolism_Homo sapiens_hsa006200.93782594
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92153020
37Maturity onset diabetes of the young_Homo sapiens_hsa049500.88787247
38Collecting duct acid secretion_Homo sapiens_hsa049660.88386133
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86733120
40Fatty acid elongation_Homo sapiens_hsa000620.85769817
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85359067
42Selenocompound metabolism_Homo sapiens_hsa004500.83299794
43Chemical carcinogenesis_Homo sapiens_hsa052040.83281607
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82884470
45* Metabolic pathways_Homo sapiens_hsa011000.81433944
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80525462
47Sulfur metabolism_Homo sapiens_hsa009200.80331087
48Peroxisome_Homo sapiens_hsa041460.77973039
49Butanoate metabolism_Homo sapiens_hsa006500.75320206
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.73781861
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71395447
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69855854
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.66940580
54Steroid biosynthesis_Homo sapiens_hsa001000.66065633
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66060668
56Sulfur relay system_Homo sapiens_hsa041220.64606684
57Tryptophan metabolism_Homo sapiens_hsa003800.62496612
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61031904
59Caffeine metabolism_Homo sapiens_hsa002320.59982791
60Nitrogen metabolism_Homo sapiens_hsa009100.59912459
61Retinol metabolism_Homo sapiens_hsa008300.57926199
62Nicotine addiction_Homo sapiens_hsa050330.54128667
63Linoleic acid metabolism_Homo sapiens_hsa005910.53942472
64Vitamin digestion and absorption_Homo sapiens_hsa049770.53524534
65Cell cycle_Homo sapiens_hsa041100.53391956
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51503080
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51273234
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.50621243
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49096323
70Tyrosine metabolism_Homo sapiens_hsa003500.47841510
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.46014110
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44351949
73beta-Alanine metabolism_Homo sapiens_hsa004100.43358469
74Regulation of autophagy_Homo sapiens_hsa041400.43285088
75Vitamin B6 metabolism_Homo sapiens_hsa007500.42668882
76Asthma_Homo sapiens_hsa053100.41268148
77Fatty acid degradation_Homo sapiens_hsa000710.40046406
78Mineral absorption_Homo sapiens_hsa049780.37149519
79Systemic lupus erythematosus_Homo sapiens_hsa053220.36675177
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31610999
81Oocyte meiosis_Homo sapiens_hsa041140.29256865
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29101049
83Olfactory transduction_Homo sapiens_hsa047400.27751958
84Taste transduction_Homo sapiens_hsa047420.25721669
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25145400
86Arachidonic acid metabolism_Homo sapiens_hsa005900.23789877
87N-Glycan biosynthesis_Homo sapiens_hsa005100.23367883
88Arginine and proline metabolism_Homo sapiens_hsa003300.17565365
89Fatty acid metabolism_Homo sapiens_hsa012120.17277381
90Epstein-Barr virus infection_Homo sapiens_hsa051690.17245455
91mRNA surveillance pathway_Homo sapiens_hsa030150.16700506
92Rheumatoid arthritis_Homo sapiens_hsa053230.16536234
93Carbon metabolism_Homo sapiens_hsa012000.16522743
94Fat digestion and absorption_Homo sapiens_hsa049750.15852601
95Ether lipid metabolism_Homo sapiens_hsa005650.15406045
96p53 signaling pathway_Homo sapiens_hsa041150.12805505
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12253941
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.12147636
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11655467
100Phenylalanine metabolism_Homo sapiens_hsa003600.09539518

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