NDUFS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.95742238
2regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.46859241
3regulation of acyl-CoA biosynthetic process (GO:0050812)6.06355048
4NADH metabolic process (GO:0006734)5.82934800
5regulation of cofactor metabolic process (GO:0051193)5.66619471
6regulation of coenzyme metabolic process (GO:0051196)5.66619471
7lysine metabolic process (GO:0006553)5.53250743
8lysine catabolic process (GO:0006554)5.53250743
9carnitine shuttle (GO:0006853)5.50753749
10succinate metabolic process (GO:0006105)5.25816031
11sarcomere organization (GO:0045214)5.10829353
12fatty acid transmembrane transport (GO:1902001)5.08940189
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.06615662
14aspartate family amino acid catabolic process (GO:0009068)5.01287424
152-oxoglutarate metabolic process (GO:0006103)4.99530231
16cardiac myofibril assembly (GO:0055003)4.97361843
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.81648366
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.80514917
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.76637718
20oxaloacetate metabolic process (GO:0006107)4.63647736
21regulation of sulfur metabolic process (GO:0042762)4.63415994
22fatty acid beta-oxidation (GO:0006635)4.62024010
23actin-myosin filament sliding (GO:0033275)4.54004809
24muscle filament sliding (GO:0030049)4.54004809
25oxidative phosphorylation (GO:0006119)4.50419500
26negative regulation of potassium ion transmembrane transport (GO:1901380)4.49745038
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.49248052
28myofibril assembly (GO:0030239)4.41361094
29regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.36677073
30response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.34244091
31skeletal muscle contraction (GO:0003009)4.32535485
32branched-chain amino acid catabolic process (GO:0009083)4.31585233
33cardiac muscle contraction (GO:0060048)4.31372524
34carnitine transmembrane transport (GO:1902603)4.24953701
35actin filament-based movement (GO:0030048)4.21058276
36tricarboxylic acid metabolic process (GO:0072350)4.20970136
37carnitine transport (GO:0015879)4.16229303
38amino-acid betaine transport (GO:0015838)4.16229303
39regulation of sequestering of triglyceride (GO:0010889)4.08603939
40acetyl-CoA metabolic process (GO:0006084)4.07056267
41cellular ketone body metabolic process (GO:0046950)4.03079952
42ATP synthesis coupled proton transport (GO:0015986)4.01060598
43energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01060598
44* respiratory electron transport chain (GO:0022904)4.00905349
45fatty acid catabolic process (GO:0009062)3.96705065
46regulation of sarcomere organization (GO:0060297)3.94555523
47cardiac muscle hypertrophy (GO:0003300)3.92066137
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.91992466
49fatty acid oxidation (GO:0019395)3.91665699
50regulation of relaxation of muscle (GO:1901077)3.91423591
51regulation of skeletal muscle contraction (GO:0014819)3.89408412
52* electron transport chain (GO:0022900)3.89268772
53short-chain fatty acid metabolic process (GO:0046459)3.86822366
54regulation of cell communication by electrical coupling (GO:0010649)3.86084845
55branched-chain amino acid metabolic process (GO:0009081)3.85926293
56lipid oxidation (GO:0034440)3.85690619
57* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84181631
58regulation of fatty acid oxidation (GO:0046320)3.82070886
59regulation of actin filament-based movement (GO:1903115)3.76514672
60actin-mediated cell contraction (GO:0070252)3.75409699
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.74797330
62sarcoplasmic reticulum calcium ion transport (GO:0070296)3.73418706
63striated muscle hypertrophy (GO:0014897)3.72912676
64positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.67402850
65biotin metabolic process (GO:0006768)3.61798800
66creatine metabolic process (GO:0006600)3.59251098
67striated muscle contraction (GO:0006941)3.59205842
68response to muscle activity (GO:0014850)3.57978397
69regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.57332924
70ketone body metabolic process (GO:1902224)3.56810256
71ventricular cardiac muscle cell action potential (GO:0086005)3.53331155
72cardiac muscle cell development (GO:0055013)3.53222329
73carnitine metabolic process (GO:0009437)3.52092455
74monocarboxylic acid catabolic process (GO:0072329)3.49904883
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48935680
76response to inactivity (GO:0014854)3.44853822
77glyoxylate metabolic process (GO:0046487)3.44355790
78valine metabolic process (GO:0006573)3.44226026
79plasma membrane repair (GO:0001778)3.42783360
80cell communication involved in cardiac conduction (GO:0086065)3.42471404
81cell communication by electrical coupling (GO:0010644)3.41459133
82quaternary ammonium group transport (GO:0015697)3.38823472
83muscle contraction (GO:0006936)3.37110890
84regulation of membrane repolarization (GO:0060306)3.36585279
85muscle hypertrophy (GO:0014896)3.32432686
86actomyosin structure organization (GO:0031032)3.31587933
87fatty acid homeostasis (GO:0055089)3.27965339
88dicarboxylic acid biosynthetic process (GO:0043650)3.22801058
89regulation of the force of heart contraction (GO:0002026)3.22274678
90cardiac cell development (GO:0055006)3.21522082
91regulation of striated muscle contraction (GO:0006942)3.19717819
92amino-acid betaine metabolic process (GO:0006577)3.19455066
93bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14643051
94positive regulation of fatty acid oxidation (GO:0046321)3.12797112
95glycogen catabolic process (GO:0005980)3.11814611
96regulation of cardiac muscle cell contraction (GO:0086004)3.11496318
97dicarboxylic acid catabolic process (GO:0043649)3.10929787
98gluconeogenesis (GO:0006094)3.10466672
99cardiac muscle adaptation (GO:0014887)3.09496160
100cardiac muscle hypertrophy in response to stress (GO:0014898)3.09496160
101muscle hypertrophy in response to stress (GO:0003299)3.09496160
102adult heart development (GO:0007512)3.06684474
103fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.06436617
104quinone biosynthetic process (GO:1901663)3.05804710
105ubiquinone biosynthetic process (GO:0006744)3.05804710
106skeletal muscle adaptation (GO:0043501)3.05589340
107cardiac muscle cell action potential (GO:0086001)3.04832633
108thioester biosynthetic process (GO:0035384)3.03770360
109acyl-CoA biosynthetic process (GO:0071616)3.03770360
110regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.03060740
111heart process (GO:0003015)3.02874151
112heart contraction (GO:0060047)3.02874151
113cardiac muscle cell action potential involved in contraction (GO:0086002)3.02152045
114cardiac muscle tissue morphogenesis (GO:0055008)3.02098141
115muscle system process (GO:0003012)3.00995413
116muscle tissue morphogenesis (GO:0060415)2.95636569
117relaxation of cardiac muscle (GO:0055119)2.90812415
118glucan catabolic process (GO:0009251)2.88285603
119response to caffeine (GO:0031000)2.86467035
120muscle fiber development (GO:0048747)2.85309365
121regulation of calcium ion transmembrane transport (GO:1903169)2.81363994
122regulation of calcium ion transmembrane transporter activity (GO:1901019)2.81363994
123positive regulation of cation channel activity (GO:2001259)2.80490113
124striated muscle adaptation (GO:0014888)2.79440916
125detection of calcium ion (GO:0005513)2.76335685
126skeletal muscle fiber development (GO:0048741)2.68174054
127myotube differentiation (GO:0014902)2.68152895
128cellular polysaccharide catabolic process (GO:0044247)2.65971325
129positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64063930
130myotube cell development (GO:0014904)2.60534440
131striated muscle cell development (GO:0055002)2.60115494
132muscle cell cellular homeostasis (GO:0046716)2.59824885
133relaxation of muscle (GO:0090075)2.58245437
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56763572
135regulation of heart rate (GO:0002027)2.50227061
136ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.49330202
137cardiac conduction (GO:0061337)2.47202029
138glucan biosynthetic process (GO:0009250)2.46249331
139glycogen biosynthetic process (GO:0005978)2.46249331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.01400655
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.60236006
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.75521018
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.30673625
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.55095146
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.20233705
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.90787427
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.90307321
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.87720798
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.81125694
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.48381344
12GBX2_23144817_ChIP-Seq_PC3_Human2.42811398
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41487278
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.34272750
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15588685
16EZH2_22144423_ChIP-Seq_EOC_Human2.13898909
17IGF1R_20145208_ChIP-Seq_DFB_Human2.02328112
18TBX20_22328084_ChIP-Seq_HEART_Mouse1.97522940
19TBX20_22080862_ChIP-Seq_HEART_Mouse1.97522940
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.94381336
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.86452442
22TAF15_26573619_Chip-Seq_HEK293_Human1.85325513
23GATA4_21415370_ChIP-Seq_HL-1_Mouse1.77828841
24CLOCK_20551151_ChIP-Seq_293T_Human1.73001437
25MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.71336920
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70721203
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69271112
28GATA1_22025678_ChIP-Seq_K562_Human1.62347775
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61045848
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56560458
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53413201
32* FLI1_27457419_Chip-Seq_LIVER_Mouse1.49092428
33* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48105632
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45602429
35ZNF263_19887448_ChIP-Seq_K562_Human1.44611587
36* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44555125
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40140326
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40114068
39AR_21909140_ChIP-Seq_LNCAP_Human1.40105202
40* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37612218
41YAP1_20516196_ChIP-Seq_MESCs_Mouse1.35474750
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35454743
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.34985195
44AR_21572438_ChIP-Seq_LNCaP_Human1.34112012
45VDR_22108803_ChIP-Seq_LS180_Human1.30811355
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30512580
47* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29418031
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29405977
49HTT_18923047_ChIP-ChIP_STHdh_Human1.28069684
50FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27119847
51BCAT_22108803_ChIP-Seq_LS180_Human1.26929707
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26441768
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25709027
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.25288132
55CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24353257
56ZNF274_21170338_ChIP-Seq_K562_Hela1.23858229
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23727335
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22492714
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21844311
60* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20892626
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20154404
62* EZH2_27294783_Chip-Seq_NPCs_Mouse1.19560578
63* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18129117
64SOX9_26525672_Chip-Seq_HEART_Mouse1.17833848
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16612046
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.16115590
67SMAD4_21799915_ChIP-Seq_A2780_Human1.15020549
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14907164
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12832881
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.11091339
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10957180
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09897139
73* E2F1_18555785_Chip-Seq_ESCs_Mouse1.08918521
74* NANOG_18555785_Chip-Seq_ESCs_Mouse1.08671318
75* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08569595
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.08352903
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08229781
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07406703
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05736656
80TP53_16413492_ChIP-PET_HCT116_Human1.04629433
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.03939036
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03938906
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03518562
84* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01804897
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.01506538
86ER_23166858_ChIP-Seq_MCF-7_Human1.01355105
87* P53_22387025_ChIP-Seq_ESCs_Mouse1.01217304
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99404877
89* CRX_20693478_ChIP-Seq_RETINA_Mouse0.98873662
90FOXA2_19822575_ChIP-Seq_HepG2_Human0.98582274
91* REST_18959480_ChIP-ChIP_MESCs_Mouse0.98347543
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98288025
93AR_19668381_ChIP-Seq_PC3_Human0.97980409
94* NFE2_27457419_Chip-Seq_LIVER_Mouse0.97068114
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96098172
96CBP_20019798_ChIP-Seq_JUKART_Human0.96098172
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95865074
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95806992
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95671697
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95613388
101* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95349677
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93639934
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93328517
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93328517
105* SOX2_18555785_Chip-Seq_ESCs_Mouse0.93252290
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92804808
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92523008
108ISL1_27105846_Chip-Seq_CPCs_Mouse0.92491769
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92237725
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92140431
111PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91812009
112CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90596048
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89578681
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88773276
115CBP_21632823_ChIP-Seq_H3396_Human0.87789231
116CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87785723
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84688677
118* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83902756
119P300_19829295_ChIP-Seq_ESCs_Human0.82766630
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82348099
121KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79826762
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79815953
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78592278
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77770639
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77680217
126SOX2_19829295_ChIP-Seq_ESCs_Human0.77628713
127NANOG_19829295_ChIP-Seq_ESCs_Human0.77628713
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76925366
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76652662
130STAT3_23295773_ChIP-Seq_U87_Human0.75810818
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74567789
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74150487
133FUS_26573619_Chip-Seq_HEK293_Human0.71639539
134AR_25329375_ChIP-Seq_VCAP_Human0.71086027
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.70080051
136* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69107538
137SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.69106287
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.68969907
139ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68498754
140THAP11_20581084_ChIP-Seq_MESCs_Mouse0.68026058
141TCF4_23295773_ChIP-Seq_U87_Human0.67822400
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.67526822
143RNF2_18974828_ChIP-Seq_MESCs_Mouse0.67526822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.74314814
2MP0003646_muscle_fatigue4.63633806
3MP0004084_abnormal_cardiac_muscle4.30870005
4MP0004215_abnormal_myocardial_fiber4.14432545
5MP0000751_myopathy4.12096549
6MP0004036_abnormal_muscle_relaxation3.57278850
7MP0000749_muscle_degeneration3.24205852
8MP0005330_cardiomyopathy3.20051966
9MP0004130_abnormal_muscle_cell3.05531267
10MP0006036_abnormal_mitochondrial_physio2.68993872
11MP0003806_abnormal_nucleotide_metabolis2.63791533
12MP0005360_urolithiasis2.59769904
13MP0002972_abnormal_cardiac_muscle2.49592468
14MP0008775_abnormal_heart_ventricle2.43911037
15MP0004087_abnormal_muscle_fiber2.40626230
16MP0005620_abnormal_muscle_contractility2.40018567
17MP0002139_abnormal_hepatobiliary_system2.31643663
18MP0005085_abnormal_gallbladder_physiolo2.30595365
19MP0003137_abnormal_impulse_conducting2.22051534
20MP0004145_abnormal_muscle_electrophysio2.20404526
21MP0005670_abnormal_white_adipose2.12814375
22MP0002269_muscular_atrophy2.10902320
23MP0004484_altered_response_of2.07691491
24MP0002106_abnormal_muscle_physiology1.99324458
25MP0001544_abnormal_cardiovascular_syste1.98428424
26MP0005385_cardiovascular_system_phenoty1.98428424
27MP0004270_analgesia1.94596795
28MP0000747_muscle_weakness1.93652723
29MP0005365_abnormal_bile_salt1.93129862
30MP0006138_congestive_heart_failure1.88926178
31MP0006035_abnormal_mitochondrial_morpho1.87805685
32MP0003221_abnormal_cardiomyocyte_apopto1.82878009
33MP0005666_abnormal_adipose_tissue1.80790373
34MP0000750_abnormal_muscle_regeneration1.76891616
35MP0004043_abnormal_pH_regulation1.76510841
36MP0010630_abnormal_cardiac_muscle1.75901015
37MP0004085_abnormal_heartbeat1.75203855
38MP0005332_abnormal_amino_acid1.69470629
39MP0004147_increased_porphyrin_level1.64935569
40MP0005369_muscle_phenotype1.63887877
41MP0004233_abnormal_muscle_weight1.61825200
42MP0000759_abnormal_skeletal_muscle1.57367659
43MP0010329_abnormal_lipoprotein_level1.42597719
44MP0002332_abnormal_exercise_endurance1.41700347
45MP0003195_calcinosis1.39300023
46MP0008875_abnormal_xenobiotic_pharmacok1.32359496
47MP0002822_catalepsy1.25260984
48MP0002971_abnormal_brown_adipose1.24045400
49MP0000013_abnormal_adipose_tissue1.19006120
50MP0005187_abnormal_penis_morphology1.18228931
51MP0002127_abnormal_cardiovascular_syste1.16964369
52MP0005266_abnormal_metabolism1.15561446
53MP0000733_abnormal_muscle_development1.14722844
54MP0005535_abnormal_body_temperature1.14049249
55MP0005375_adipose_tissue_phenotype1.12140765
56MP0002118_abnormal_lipid_homeostasis1.11306234
57MP0003252_abnormal_bile_duct1.10042926
58MP0003941_abnormal_skin_development1.08988274
59MP0009780_abnormal_chondrocyte_physiolo1.08592540
60MP0005584_abnormal_enzyme/coenzyme_acti1.08547287
61MP0005319_abnormal_enzyme/_coenzyme1.02680368
62MP0010234_abnormal_vibrissa_follicle1.02271636
63MP0001299_abnormal_eye_distance/1.02015135
64MP0003950_abnormal_plasma_membrane1.01397326
65MP0002078_abnormal_glucose_homeostasis1.00216254
66MP0003828_pulmonary_edema0.99343125
67MP0002009_preneoplasia0.95301031
68MP0000230_abnormal_systemic_arterial0.92333797
69MP0008057_abnormal_DNA_replication0.88617893
70MP0004185_abnormal_adipocyte_glucose0.88447932
71MP0009697_abnormal_copulation0.83481467
72MP0003567_abnormal_fetal_cardiomyocyte0.82035105
73MP0001984_abnormal_olfaction0.81897735
74MP0003868_abnormal_feces_composition0.81877942
75MP0002909_abnormal_adrenal_gland0.81142379
76MP0005386_behavior/neurological_phenoty0.80430684
77MP0004924_abnormal_behavior0.80430684
78MP0003045_fibrosis0.80015231
79MP0002638_abnormal_pupillary_reflex0.79477879
80MP0000003_abnormal_adipose_tissue0.76541426
81MP0002108_abnormal_muscle_morphology0.76514342
82MP0009046_muscle_twitch0.72841696
83MP0000266_abnormal_heart_morphology0.70543055
84MP0001764_abnormal_homeostasis0.70420671
85MP0005165_increased_susceptibility_to0.69408001
86MP0005083_abnormal_biliary_tract0.67913334
87MP0009643_abnormal_urine_homeostasis0.66749457
88MP0005334_abnormal_fat_pad0.66445625
89MP0003329_amyloid_beta_deposits0.66141235
90MP0010352_gastrointestinal_tract_polyps0.65675837
91MP0009745_abnormal_behavioral_response0.64757866
92MP0003879_abnormal_hair_cell0.62996663
93MP0000609_abnormal_liver_physiology0.62648004
94MP0001666_abnormal_nutrient_absorption0.61974442
95MP0001529_abnormal_vocalization0.61944161
96MP0001486_abnormal_startle_reflex0.61037439
97MP0002876_abnormal_thyroid_physiology0.60538612
98MP0009672_abnormal_birth_weight0.60217276
99MP0003890_abnormal_embryonic-extraembry0.60081610
100MP0008569_lethality_at_weaning0.60021160
101MP0004859_abnormal_synaptic_plasticity0.59568266
102MP0005451_abnormal_body_composition0.58788508
103MP0003635_abnormal_synaptic_transmissio0.58195490
104MP0005448_abnormal_energy_balance0.57996888
105MP0008961_abnormal_basal_metabolism0.57112338
106MP0002272_abnormal_nervous_system0.57036382
107MP0000343_altered_response_to0.56768402
108MP0002734_abnormal_mechanical_nocicepti0.56125894
109MP0005452_abnormal_adipose_tissue0.54975495
110MP0005376_homeostasis/metabolism_phenot0.54808228
111MP0003136_yellow_coat_color0.54685843
112MP0003186_abnormal_redox_activity0.53637413
113MP0002064_seizures0.53449094
114MP0001440_abnormal_grooming_behavior0.52485670
115MP0000569_abnormal_digit_pigmentation0.51946229
116MP0001661_extended_life_span0.51481779
117MP0003880_abnormal_central_pattern0.50331058
118MP0004510_myositis0.50233427
119MP0005423_abnormal_somatic_nervous0.49718950
120MP0003656_abnormal_erythrocyte_physiolo0.49508542
121MP0010368_abnormal_lymphatic_system0.49266997
122MP0001756_abnormal_urination0.48765353
123MP0004272_abnormal_basement_membrane0.48631641
124MP0002067_abnormal_sensory_capabilities0.48471318
125MP0002066_abnormal_motor_capabilities/c0.48145975
126MP0004142_abnormal_muscle_tone0.47992343
127MP0003937_abnormal_limbs/digits/tail_de0.46920782
128MP0002063_abnormal_learning/memory/cond0.46357123
129MP0002128_abnormal_blood_circulation0.45542904

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.27236160
2Myoglobinuria (HP:0002913)5.27024272
3Exercise-induced myalgia (HP:0003738)5.16394038
4Exercise-induced muscle cramps (HP:0003710)5.03720708
5Calf muscle hypertrophy (HP:0008981)4.52014649
6Muscle hypertrophy of the lower extremities (HP:0008968)4.29117013
7Distal arthrogryposis (HP:0005684)4.23984095
8Rhabdomyolysis (HP:0003201)4.20304357
9Ketoacidosis (HP:0001993)4.00197825
10Hepatic necrosis (HP:0002605)3.96672410
11Ventricular tachycardia (HP:0004756)3.90418928
12Increased serum pyruvate (HP:0003542)3.88348165
13Abnormality of glycolysis (HP:0004366)3.88348165
14Hypoglycemic coma (HP:0001325)3.83173752
15Abnormality of fatty-acid metabolism (HP:0004359)3.81751877
16Palpitations (HP:0001962)3.71981660
17Atrial fibrillation (HP:0005110)3.67723626
18Hyperglycinuria (HP:0003108)3.63272974
19Abnormality of the calf musculature (HP:0001430)3.59975912
20* Abnormal mitochondria in muscle tissue (HP:0008316)3.58513991
21Centrally nucleated skeletal muscle fibers (HP:0003687)3.49749835
22Abnormality of dicarboxylic acid metabolism (HP:0010995)3.48246299
23Dicarboxylic aciduria (HP:0003215)3.48246299
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.45288161
25Abnormality of alanine metabolism (HP:0010916)3.45288161
26Hyperalaninemia (HP:0003348)3.45288161
27Ketosis (HP:0001946)3.43513925
28Hepatocellular necrosis (HP:0001404)3.43000642
29Frequent falls (HP:0002359)3.38315134
30Primary atrial arrhythmia (HP:0001692)3.38081311
31Lipoatrophy (HP:0100578)3.35962118
32Neck muscle weakness (HP:0000467)3.35195259
33* Acute encephalopathy (HP:0006846)3.35168210
34Muscle fiber splitting (HP:0003555)3.34492933
35* Cerebral edema (HP:0002181)3.33234204
36* Acute necrotizing encephalopathy (HP:0006965)3.32536915
37Hyperammonemia (HP:0001987)3.28379131
38Supraventricular tachycardia (HP:0004755)3.27679274
39Myopathic facies (HP:0002058)3.23893171
40Syncope (HP:0001279)3.21502171
41Abnormality of glycine metabolism (HP:0010895)3.20176054
42Abnormality of serine family amino acid metabolism (HP:0010894)3.20176054
43Supraventricular arrhythmia (HP:0005115)3.19906739
44Pheochromocytoma (HP:0002666)3.14185524
45Dilated cardiomyopathy (HP:0001644)3.12305280
46Hyporeflexia of lower limbs (HP:0002600)3.07110943
47Right ventricular cardiomyopathy (HP:0011663)3.02366605
48* Increased CSF lactate (HP:0002490)3.00557164
49Subaortic stenosis (HP:0001682)2.96967007
50Abnormality of the left ventricular outflow tract (HP:0011103)2.96967007
51Ragged-red muscle fibers (HP:0003200)2.96704499
52* Lactic acidosis (HP:0003128)2.94175010
53Increased muscle lipid content (HP:0009058)2.89825966
54EMG: neuropathic changes (HP:0003445)2.89434067
55EMG: myopathic abnormalities (HP:0003458)2.88082230
56Round ear (HP:0100830)2.85831981
57Neuroendocrine neoplasm (HP:0100634)2.84773625
58* Mitochondrial inheritance (HP:0001427)2.80040137
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.78873520
60* Progressive macrocephaly (HP:0004481)2.78166755
61Generalized aminoaciduria (HP:0002909)2.78161996
62Ventricular arrhythmia (HP:0004308)2.73849374
63Muscle stiffness (HP:0003552)2.72679993
64Bundle branch block (HP:0011710)2.69821336
65Prolonged QT interval (HP:0001657)2.69769646
66Areflexia of lower limbs (HP:0002522)2.68561211
67Hyperglycinemia (HP:0002154)2.67237474
68Increased connective tissue (HP:0009025)2.59427382
69Abnormality of skeletal muscle fiber size (HP:0012084)2.58796215
70Metabolic acidosis (HP:0001942)2.58180321
71Dysmetric saccades (HP:0000641)2.57379156
72Asymmetric septal hypertrophy (HP:0001670)2.56749340
73Distal lower limb muscle weakness (HP:0009053)2.56070481
74Myotonia (HP:0002486)2.55625735
75Conjunctival hamartoma (HP:0100780)2.54401106
76Neoplasm of the adrenal gland (HP:0100631)2.53879214
77Difficulty running (HP:0009046)2.53873129
78* Lethargy (HP:0001254)2.52860849
79Muscle fiber inclusion bodies (HP:0100299)2.44459814
80Proximal tubulopathy (HP:0000114)2.42773807
81Increased intramyocellular lipid droplets (HP:0012240)2.41087137
82Heart block (HP:0012722)2.40984712
83Calcaneovalgus deformity (HP:0001848)2.39758761
84Atrioventricular block (HP:0001678)2.38104238
85Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.34174302
86* Exercise intolerance (HP:0003546)2.33598902
87* Respiratory failure (HP:0002878)2.33172544
88Limb-girdle muscle atrophy (HP:0003797)2.31487867
89Ulnar deviation of the wrist (HP:0003049)2.31226696
90Abnormality of serum amino acid levels (HP:0003112)2.30725703
91Generalized muscle weakness (HP:0003324)2.27809829
92Increased variability in muscle fiber diameter (HP:0003557)2.27073763
93Mildly elevated creatine phosphokinase (HP:0008180)2.26543971
94Gout (HP:0001997)2.23926639
95Increased serum lactate (HP:0002151)2.23738397
96Scapular winging (HP:0003691)2.22845701
97Rimmed vacuoles (HP:0003805)2.21324178
98Hypoalphalipoproteinemia (HP:0003233)2.21255750
99Abnormal atrioventricular conduction (HP:0005150)2.18636653
100Methylmalonic aciduria (HP:0012120)2.14162099
101Ventricular fibrillation (HP:0001663)2.13987355
102Cholelithiasis (HP:0001081)2.13047245
103* Vomiting (HP:0002013)2.12386722
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12288003
105Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12288003
106Hyperkalemia (HP:0002153)2.10938975
107Absent phalangeal crease (HP:0006109)2.09810639
108Type 1 muscle fiber predominance (HP:0003803)2.09118418
109Renal cortical cysts (HP:0000803)2.08519287
110Left ventricular hypertrophy (HP:0001712)2.07768545
111Hyperinsulinemic hypoglycemia (HP:0000825)2.07389847
112CNS demyelination (HP:0007305)2.07246114
113Abnormal finger flexion creases (HP:0006143)2.03663439
114Hamartoma of the eye (HP:0010568)2.02172473
115Central scotoma (HP:0000603)2.01858294
116Deformed tarsal bones (HP:0008119)2.01049087
117Hyperuricemia (HP:0002149)1.99867425
118Increased purine levels (HP:0004368)1.99867425
119Nausea (HP:0002018)1.99833842
120Fetal akinesia sequence (HP:0001989)1.99277160
121Proximal amyotrophy (HP:0007126)1.98560620
122Abnormal EKG (HP:0003115)1.97911934
123Nemaline bodies (HP:0003798)1.97387565
124Athetosis (HP:0002305)1.96444274
125Distal lower limb amyotrophy (HP:0008944)1.93112991
126Abnormality of the foot musculature (HP:0001436)1.88976042
127Malignant hyperthermia (HP:0002047)1.87839146
128Lower limb amyotrophy (HP:0007210)1.81677997
129Abnormality of the shoulder girdle musculature (HP:0001435)1.80877520
130Gowers sign (HP:0003391)1.77567318
131Steppage gait (HP:0003376)1.73577035
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73037819
133Muscular dystrophy (HP:0003560)1.72586775
134Shoulder girdle muscle weakness (HP:0003547)1.69306030
135Abnormality of the hip-girdle musculature (HP:0001445)1.69193163
136Abnormality of the musculature of the pelvis (HP:0001469)1.69193163
137Progressive muscle weakness (HP:0003323)1.62228369
138Papillary thyroid carcinoma (HP:0002895)1.60887885
139Limb-girdle muscle weakness (HP:0003325)1.59502410
140Foot dorsiflexor weakness (HP:0009027)1.58986316
141Long clavicles (HP:0000890)1.57485046
142Hip contracture (HP:0003273)1.55895760
143Pelvic girdle muscle weakness (HP:0003749)1.49485210
144Limited hip movement (HP:0008800)1.47470374
145Abnormality of potassium homeostasis (HP:0011042)1.44860546
146Abnormality of the calcaneus (HP:0008364)1.42336687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.20767612
2PDK35.20767612
3OBSCN4.38688325
4NEK14.08907635
5BCKDK3.94957609
6TTN3.73960748
7LMTK23.37799554
8PHKG13.21239686
9PHKG23.21239686
10PDK23.13252394
11MYLK2.48436797
12PKN22.41756972
13PINK12.33375828
14MARK11.92545685
15EEF2K1.77662950
16TRIB31.71234185
17PIK3CA1.60895174
18WNK41.57068175
19STK241.56811078
20MAP2K41.54459882
21TIE11.50533841
22INSRR1.39729034
23ERBB31.33056720
24STK38L1.31368906
25ACVR1B1.28599836
26MAP3K41.25753847
27FRK1.24144210
28TRPM71.16532256
29CASK1.14632592
30BRSK21.12363060
31GRK71.10462129
32SCYL21.07449863
33MAP3K71.02923596
34DMPK1.02389463
35ICK1.01792273
36LATS11.00512789
37CCNB11.00331910
38WNK31.00121333
39CAMK2D0.97744688
40FLT30.95999533
41NME10.95870364
42NTRK30.95597524
43EPHA40.95239846
44LATS20.94762947
45MAPK120.93954733
46MAPKAPK30.92984452
47PBK0.90574252
48MET0.90478348
49PAK30.89879982
50PRKAA10.89211605
51SGK20.87903791
52LIMK10.84662784
53MUSK0.83057890
54BMPR1B0.82759522
55EPHA30.80851875
56OXSR10.80584927
57MAP2K70.78991220
58TTK0.76610592
59SGK30.74341725
60NEK90.74284742
61SGK2230.73989253
62SGK4940.73989253
63PRKAA20.72731345
64ZAK0.72501202
65CAMK2A0.70790931
66STK390.67420638
67MST1R0.66785822
68RPS6KB10.66065930
69ROCK10.65616084
70TSSK60.65442224
71AKT30.65242541
72CAMK2G0.62972267
73MAP3K120.62556290
74CAMKK20.59280179
75PRKD10.57116723
76PNCK0.56897798
77MAP3K50.54809904
78CAMK40.54461345
79CAMK1G0.54440197
80MINK10.52797238
81STK380.52658463
82PRKACG0.52591515
83PRKACB0.52321971
84MAP3K60.51811688
85ILK0.51637404
86WNK10.51283715
87PLK20.50772722
88SIK10.50629111
89PRKCG0.50190836
90RPS6KB20.49751292
91PRKACA0.48278354
92MAPK100.47740009
93PDPK10.47659579
94PDK10.47428338
95CSNK1G10.47253538
96NTRK10.46251286
97FGFR30.45572819
98BCR0.45177816
99DAPK20.44434579
100RET0.44354583
101CSNK1E0.44287684
102MAP2K30.44138845
103MAPK110.44107813
104AKT20.42037298
105CSNK1A1L0.40857965
106CAMK10.40771470
107SGK10.40012634
108CSNK1G20.39038871
109PTK2B0.38546393
110PRKG10.38438607
111PRKCE0.38308767
112EIF2AK10.38180445
113EIF2AK30.38027780
114PRKDC0.36283995
115CAMK2B0.36152179
116CDC42BPA0.35826626
117KSR20.35372735
118MAP2K10.35067648
119CAMK1D0.33895777
120PIK3CG0.33691100
121DAPK30.32691778
122CDK50.32617774
123TNIK0.32366765
124PRKD30.31439792
125KSR10.30388943
126MAPK70.30063025
127ROCK20.29247440
128RPS6KA30.28058242
129FER0.27019708
130DAPK10.25741800
131FGFR10.25669140
132PAK60.23725310
133PRPF4B0.23457265
134PKN10.22351900
135PDGFRA0.20879924
136ERBB40.19290741
137PRKCH0.18972188
138MAP2K60.18647708
139RIPK10.17924243
140FGFR40.17791154

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.72454138
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.44302274
3Propanoate metabolism_Homo sapiens_hsa006403.86230713
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39293885
5Fatty acid degradation_Homo sapiens_hsa000713.29010072
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.07147556
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.80015433
8Carbon metabolism_Homo sapiens_hsa012002.73891935
9Fatty acid metabolism_Homo sapiens_hsa012122.73507250
10Pyruvate metabolism_Homo sapiens_hsa006202.62471049
11Butanoate metabolism_Homo sapiens_hsa006502.45746922
12* Oxidative phosphorylation_Homo sapiens_hsa001902.22701043
13Cardiac muscle contraction_Homo sapiens_hsa042602.22492994
14Parkinsons disease_Homo sapiens_hsa050122.07003573
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06607264
16Fatty acid elongation_Homo sapiens_hsa000621.70837822
17Biosynthesis of amino acids_Homo sapiens_hsa012301.69036325
18Arginine biosynthesis_Homo sapiens_hsa002201.63847392
19PPAR signaling pathway_Homo sapiens_hsa033201.63271349
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60518580
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59963697
22Tryptophan metabolism_Homo sapiens_hsa003801.57641581
23beta-Alanine metabolism_Homo sapiens_hsa004101.51040785
24Dilated cardiomyopathy_Homo sapiens_hsa054141.49004472
25Peroxisome_Homo sapiens_hsa041461.48685802
26Alzheimers disease_Homo sapiens_hsa050101.46040426
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43203968
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.37887766
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33981597
30Nitrogen metabolism_Homo sapiens_hsa009101.25716471
31* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25006410
32Huntingtons disease_Homo sapiens_hsa050161.23550071
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15398814
34Fatty acid biosynthesis_Homo sapiens_hsa000611.13290605
35Starch and sucrose metabolism_Homo sapiens_hsa005001.12873948
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05523511
37Phenylalanine metabolism_Homo sapiens_hsa003601.02379966
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.01475335
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95989402
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95276669
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93023279
42Glucagon signaling pathway_Homo sapiens_hsa049220.90925703
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83632729
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81167644
45Arginine and proline metabolism_Homo sapiens_hsa003300.79360408
46Tight junction_Homo sapiens_hsa045300.77999548
47One carbon pool by folate_Homo sapiens_hsa006700.77785386
48Bile secretion_Homo sapiens_hsa049760.75371070
49Tyrosine metabolism_Homo sapiens_hsa003500.75076411
50Fructose and mannose metabolism_Homo sapiens_hsa000510.74995469
51Sulfur metabolism_Homo sapiens_hsa009200.72725417
52Glycerolipid metabolism_Homo sapiens_hsa005610.65145559
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.61348816
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61248869
55Lysine degradation_Homo sapiens_hsa003100.59654649
56Galactose metabolism_Homo sapiens_hsa000520.59533414
57Insulin signaling pathway_Homo sapiens_hsa049100.58069850
58Amphetamine addiction_Homo sapiens_hsa050310.57182429
59Pentose phosphate pathway_Homo sapiens_hsa000300.57114556
60Insulin resistance_Homo sapiens_hsa049310.56993551
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56498467
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55794891
63* Metabolic pathways_Homo sapiens_hsa011000.54659727
64Adherens junction_Homo sapiens_hsa045200.54267556
65Fat digestion and absorption_Homo sapiens_hsa049750.52566408
66Collecting duct acid secretion_Homo sapiens_hsa049660.52208128
67Thyroid hormone synthesis_Homo sapiens_hsa049180.51903168
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51801242
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51505593
70Dopaminergic synapse_Homo sapiens_hsa047280.49878647
71AMPK signaling pathway_Homo sapiens_hsa041520.48798430
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48580621
73Pancreatic secretion_Homo sapiens_hsa049720.46975660
74Calcium signaling pathway_Homo sapiens_hsa040200.46371546
75Glutamatergic synapse_Homo sapiens_hsa047240.46291734
76Selenocompound metabolism_Homo sapiens_hsa004500.45703087
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44193853
78Oocyte meiosis_Homo sapiens_hsa041140.41772649
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41297046
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39857026
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38597620
82cAMP signaling pathway_Homo sapiens_hsa040240.36670699
83Ovarian steroidogenesis_Homo sapiens_hsa049130.36139375
84Long-term depression_Homo sapiens_hsa047300.35579290
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34243036
86Salivary secretion_Homo sapiens_hsa049700.33606928
87Histidine metabolism_Homo sapiens_hsa003400.31962046
88Focal adhesion_Homo sapiens_hsa045100.31595064
89Renin secretion_Homo sapiens_hsa049240.29938528
90Nicotine addiction_Homo sapiens_hsa050330.29855621
91Cholinergic synapse_Homo sapiens_hsa047250.29636224
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.29359945
93ABC transporters_Homo sapiens_hsa020100.28876294
94Insulin secretion_Homo sapiens_hsa049110.28051111
95Non-homologous end-joining_Homo sapiens_hsa034500.27919522
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27529031
97Synaptic vesicle cycle_Homo sapiens_hsa047210.27392419
98GABAergic synapse_Homo sapiens_hsa047270.27381340
99Circadian entrainment_Homo sapiens_hsa047130.26932867
100Gastric acid secretion_Homo sapiens_hsa049710.26795167
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26511957
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.25961930
103Complement and coagulation cascades_Homo sapiens_hsa046100.25899693
104Oxytocin signaling pathway_Homo sapiens_hsa049210.25752750
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.25692635
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24857246
107Chemical carcinogenesis_Homo sapiens_hsa052040.24410883
108Olfactory transduction_Homo sapiens_hsa047400.23285460
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22629201
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22045954
111Vitamin B6 metabolism_Homo sapiens_hsa007500.19286126
112Glutathione metabolism_Homo sapiens_hsa004800.17724389
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17721810
114Morphine addiction_Homo sapiens_hsa050320.16395373
115Type II diabetes mellitus_Homo sapiens_hsa049300.15761329
116Circadian rhythm_Homo sapiens_hsa047100.14363300
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.13613057
118Retinol metabolism_Homo sapiens_hsa008300.12987984
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.12455801
120Long-term potentiation_Homo sapiens_hsa047200.12043277
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11800565

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