NDUFS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.20399976
2lysine metabolic process (GO:0006553)5.69935515
3lysine catabolic process (GO:0006554)5.69935515
4NADH metabolic process (GO:0006734)5.67067509
5carnitine shuttle (GO:0006853)5.40979750
6sarcomere organization (GO:0045214)5.29657617
7regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.25773138
82-oxoglutarate metabolic process (GO:0006103)5.23817219
9tricarboxylic acid metabolic process (GO:0072350)5.04565632
10fatty acid transmembrane transport (GO:1902001)4.99135920
11fatty acid beta-oxidation (GO:0006635)4.87585913
12aspartate family amino acid catabolic process (GO:0009068)4.86817384
13succinate metabolic process (GO:0006105)4.83510229
14regulation of acyl-CoA biosynthetic process (GO:0050812)4.74046104
15oxaloacetate metabolic process (GO:0006107)4.71908563
16cardiac myofibril assembly (GO:0055003)4.60774843
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.56938740
18regulation of coenzyme metabolic process (GO:0051196)4.49732356
19regulation of cofactor metabolic process (GO:0051193)4.49732356
20actin-myosin filament sliding (GO:0033275)4.38860458
21muscle filament sliding (GO:0030049)4.38860458
22negative regulation of potassium ion transmembrane transport (GO:1901380)4.35950300
23cullin deneddylation (GO:0010388)4.24024135
24fatty acid catabolic process (GO:0009062)4.21202368
25fatty acid oxidation (GO:0019395)4.19988493
26carnitine transmembrane transport (GO:1902603)4.19420156
27regulation of fatty acid oxidation (GO:0046320)4.17357458
28amino-acid betaine transport (GO:0015838)4.14344074
29carnitine transport (GO:0015879)4.14344074
30branched-chain amino acid catabolic process (GO:0009083)4.14284374
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.13148080
32valine metabolic process (GO:0006573)4.12137524
33lipid oxidation (GO:0034440)4.10836239
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.10739206
35regulation of sequestering of triglyceride (GO:0010889)4.10176984
36myofibril assembly (GO:0030239)4.09789973
37proteasome assembly (GO:0043248)4.08744731
38oxidative phosphorylation (GO:0006119)4.08125846
39cardiac muscle contraction (GO:0060048)4.05943896
40acetyl-CoA metabolic process (GO:0006084)4.04059767
41regulation of cellular amino acid metabolic process (GO:0006521)3.98973851
42protein deneddylation (GO:0000338)3.96998781
43regulation of mitochondrial translation (GO:0070129)3.96521539
44branched-chain amino acid metabolic process (GO:0009081)3.95488199
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.94724251
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94069783
47plasma membrane repair (GO:0001778)3.92015085
48short-chain fatty acid metabolic process (GO:0046459)3.90217146
49regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.89841614
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.89708333
51regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.81092144
52cellular ketone body metabolic process (GO:0046950)3.78059039
53glyoxylate metabolic process (GO:0046487)3.75412200
54negative regulation of ligase activity (GO:0051352)3.72226474
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72226474
56L-serine metabolic process (GO:0006563)3.70236230
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68610766
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.67385142
59monocarboxylic acid catabolic process (GO:0072329)3.66890448
60regulation of skeletal muscle contraction (GO:0014819)3.66889218
61regulation of sulfur metabolic process (GO:0042762)3.66161517
62ubiquinone biosynthetic process (GO:0006744)3.65103214
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59186828
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59186828
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59186828
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.58536833
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.58536833
68establishment of integrated proviral latency (GO:0075713)3.57756919
69carnitine metabolic process (GO:0009437)3.56704354
70biotin metabolic process (GO:0006768)3.54497291
71positive regulation of fatty acid oxidation (GO:0046321)3.51811941
72actin-mediated cell contraction (GO:0070252)3.51729340
73regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.50682285
74* respiratory electron transport chain (GO:0022904)3.50327847
75ATP synthesis coupled proton transport (GO:0015986)3.48603463
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.48603463
77ubiquinone metabolic process (GO:0006743)3.47994398
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.47592232
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.46271536
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.46271536
814-hydroxyproline metabolic process (GO:0019471)3.46025327
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45701575
83quaternary ammonium group transport (GO:0015697)3.45549351
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.45084114
85DNA damage response, detection of DNA damage (GO:0042769)3.44092567
86ventricular cardiac muscle cell action potential (GO:0086005)3.43896691
87protein complex biogenesis (GO:0070271)3.42143032
88* electron transport chain (GO:0022900)3.40945781
89fatty acid homeostasis (GO:0055089)3.39211280
90sarcoplasmic reticulum calcium ion transport (GO:0070296)3.39160389
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.39090592
92cardiac muscle cell development (GO:0055013)3.38936716
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.36979889
94regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.36938626
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36549221
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.36247826
97L-phenylalanine metabolic process (GO:0006558)3.36247826
98bundle of His cell to Purkinje myocyte communication (GO:0086069)3.35845473
99chaperone-mediated protein transport (GO:0072321)3.35524415
100gluconeogenesis (GO:0006094)3.35123325
101creatine metabolic process (GO:0006600)3.34064010
102monosaccharide biosynthetic process (GO:0046364)3.31192106
103amino-acid betaine metabolic process (GO:0006577)3.30461257
104actomyosin structure organization (GO:0031032)3.30084714
105ketone body metabolic process (GO:1902224)3.29872984
106mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29458768
107mitochondrial respiratory chain complex I assembly (GO:0032981)3.29458768
108NADH dehydrogenase complex assembly (GO:0010257)3.29458768
109regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.24449844
110quinone biosynthetic process (GO:1901663)3.23662978
111striated muscle contraction (GO:0006941)3.23217865
112aldehyde catabolic process (GO:0046185)3.21042823
113regulation of actin filament-based movement (GO:1903115)3.20907773
114positive regulation of ligase activity (GO:0051351)3.20699052
115regulation of fatty acid beta-oxidation (GO:0031998)3.20483599
116glycolytic process (GO:0006096)3.20214134
117alpha-linolenic acid metabolic process (GO:0036109)3.18386879
118L-methionine salvage (GO:0071267)3.16594642
119L-methionine biosynthetic process (GO:0071265)3.16594642
120amino acid salvage (GO:0043102)3.16594642
121mitochondrial respiratory chain complex assembly (GO:0033108)3.15377851
122erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.13862327
123L-phenylalanine catabolic process (GO:0006559)3.13862327
124cardiac cell development (GO:0055006)3.12031307
125positive regulation of mitochondrial fission (GO:0090141)3.06962469
126DNA ligation (GO:0006266)3.06576949
127Golgi transport vesicle coating (GO:0048200)3.06555958
128COPI coating of Golgi vesicle (GO:0048205)3.06555958
129* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06402406
130hexose biosynthetic process (GO:0019319)3.06320016
131respiratory chain complex IV assembly (GO:0008535)3.05164524
132heart trabecula formation (GO:0060347)3.05087112
133regulation of cellular amine metabolic process (GO:0033238)3.03849237
134cardiac muscle hypertrophy (GO:0003300)3.03382262
135cell communication involved in cardiac conduction (GO:0086065)3.00911917
136iron-sulfur cluster assembly (GO:0016226)2.99766158
137metallo-sulfur cluster assembly (GO:0031163)2.99766158
138regulation of ubiquitin-protein transferase activity (GO:0051438)2.98747843
139aerobic respiration (GO:0009060)2.97346471
140regulation of relaxation of muscle (GO:1901077)2.96997472
141ATP biosynthetic process (GO:0006754)2.96088958
142inner mitochondrial membrane organization (GO:0007007)2.95119928
143protein targeting to mitochondrion (GO:0006626)2.95025739
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.93567922
145cell communication by electrical coupling (GO:0010644)2.93419424
146response to mercury ion (GO:0046689)2.92067994
147thioester biosynthetic process (GO:0035384)2.91627932
148acyl-CoA biosynthetic process (GO:0071616)2.91627932
149heart process (GO:0003015)2.90862084
150heart contraction (GO:0060047)2.90862084
151striated muscle hypertrophy (GO:0014897)2.89193121
152establishment of viral latency (GO:0019043)2.88285819
153regulation of ligase activity (GO:0051340)2.87034212
154tRNA aminoacylation for protein translation (GO:0006418)2.86585210
155carboxylic acid catabolic process (GO:0046395)2.86163524
156organic acid catabolic process (GO:0016054)2.86163524
157RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82485578
158tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82485578
159deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79358183
160purine nucleoside monophosphate biosynthetic process (GO:0009127)2.77380600
161purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.77380600
162amino acid activation (GO:0043038)2.77353725
163tRNA aminoacylation (GO:0043039)2.77353725
164cellular respiration (GO:0045333)2.76967751
165cytochrome complex assembly (GO:0017004)2.75607105
166protein localization to mitochondrion (GO:0070585)2.75204073
167energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.74344549
168ATP hydrolysis coupled proton transport (GO:0015991)2.74344549
169establishment of protein localization to mitochondrion (GO:0072655)2.70902374
170purine nucleoside triphosphate biosynthetic process (GO:0009145)2.70083413
171hydrogen ion transmembrane transport (GO:1902600)2.68491082
172mitochondrial transport (GO:0006839)2.66609798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.34009030
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.70906202
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.20764443
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.69982567
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.65752161
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.57876525
7RXR_22158963_ChIP-Seq_LIVER_Mouse4.48617590
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.24501808
9* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.90445463
10* GABP_17652178_ChIP-ChIP_JURKAT_Human3.88885775
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.88263431
12* EST1_17652178_ChIP-ChIP_JURKAT_Human3.55524921
13LXR_22158963_ChIP-Seq_LIVER_Mouse3.51853611
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.48674786
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.27557932
16* ETS1_20019798_ChIP-Seq_JURKAT_Human3.22572893
17MYC_18555785_ChIP-Seq_MESCs_Mouse3.12978117
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.95147699
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.87751412
20CLOCK_20551151_ChIP-Seq_293T_Human2.80801206
21ZNF263_19887448_ChIP-Seq_K562_Human2.78363197
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72224454
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66314896
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65088462
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.56899835
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56740148
27* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.31456413
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28897274
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28374508
30DCP1A_22483619_ChIP-Seq_HELA_Human2.26380759
31TBX20_22080862_ChIP-Seq_HEART_Mouse2.26259969
32TBX20_22328084_ChIP-Seq_HEART_Mouse2.26259969
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.18785622
34E2F7_22180533_ChIP-Seq_HELA_Human2.17069280
35* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16513889
36XRN2_22483619_ChIP-Seq_HELA_Human2.15752958
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11620916
38GABP_19822575_ChIP-Seq_HepG2_Human2.10366862
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03170638
40ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02775829
41VDR_23849224_ChIP-Seq_CD4+_Human1.91310045
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90925098
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90476055
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89497180
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.88201270
46ELK1_19687146_ChIP-ChIP_HELA_Human1.86809806
47FOXP3_21729870_ChIP-Seq_TREG_Human1.84944324
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84550570
49* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76897335
50* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71182983
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68438598
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.68289994
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66898911
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65392248
55TTF2_22483619_ChIP-Seq_HELA_Human1.64177010
56GATA1_22025678_ChIP-Seq_K562_Human1.62508788
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62258163
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57938862
59MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.55967373
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55763170
61LXR_22292898_ChIP-Seq_THP-1_Human1.53828795
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52151573
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51054625
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50983067
65TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50925206
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47656480
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47469335
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40992290
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40432025
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40004964
71GATA4_21415370_ChIP-Seq_HL-1_Mouse1.39123263
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36657225
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33836217
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.33516713
75* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32940040
76ATF3_27146783_Chip-Seq_COLON_Human1.32739699
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.28839743
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28761880
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27888631
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26509044
81* KDM5A_27292631_Chip-Seq_BREAST_Human1.26422354
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26320750
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26224835
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26053937
85NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24262235
86* RACK7_27058665_Chip-Seq_MCF-7_Human1.21350524
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21230511
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20979361
89* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20943795
90P68_20966046_ChIP-Seq_HELA_Human1.19548711
91* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18847556
92MYC_18940864_ChIP-ChIP_HL60_Human1.17310339
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17045805
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15857263
95* CIITA_25753668_ChIP-Seq_RAJI_Human1.11321679
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09799230
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08530804
98* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08337498
99FOXA2_19822575_ChIP-Seq_HepG2_Human1.07847152
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.07620576
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05987892
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03854727
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.03334927
104BCOR_27268052_Chip-Seq_Bcells_Human1.01203549
105BCL6_27268052_Chip-Seq_Bcells_Human0.99293478
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98326790
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98271170
108IGF1R_20145208_ChIP-Seq_DFB_Human0.94607482
109AR_21909140_ChIP-Seq_LNCAP_Human0.93658702
110TP63_22573176_ChIP-Seq_HFKS_Human0.92924482
111* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92710291
112* TET1_21451524_ChIP-Seq_MESCs_Mouse0.92704757
113* SOX17_20123909_ChIP-Seq_XEN_Mouse0.92621051
114RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92520601
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91797576
116GATA1_19941826_ChIP-Seq_K562_Human0.91387206
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91232882
118ELK1_22589737_ChIP-Seq_MCF10A_Human0.91132715
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90824585
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.90562215
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90541439
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90479097
123CTCF_27219007_Chip-Seq_Bcells_Human0.90333703
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89275318
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89097415
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88244971
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88212687
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87174887
129* CREB1_26743006_Chip-Seq_LNCaP_Human0.87134798
130* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87049058
131HNF4A_19822575_ChIP-Seq_HepG2_Human0.86853107
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86416577
133SOX2_16153702_ChIP-ChIP_HESCs_Human0.86162847
134ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85472688
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.85451570
136* ELK3_25401928_ChIP-Seq_HUVEC_Human0.84966858
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84550058
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84402992
139CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84259658
140EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84135758
141* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83961162
142EOMES_21245162_ChIP-Seq_HESCs_Human0.83786699
143CTCF_21964334_Chip-Seq_Bcells_Human0.83427443
144* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83360401
145ZNF274_21170338_ChIP-Seq_K562_Hela0.81730298
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80502459
147TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80490512
148OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80281791
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79895639
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79867535
151CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79194707
152DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79090562
153SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77967539
154* NANOG_16153702_ChIP-ChIP_HESCs_Human0.77316343
155MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77099966
156* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76670280
157NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75477664
158FOXP1_21924763_ChIP-Seq_HESCs_Human0.74360959
159FOXH1_21741376_ChIP-Seq_ESCs_Human0.74078049
160PHF8_20622854_ChIP-Seq_HELA_Human0.73589109
161SMC4_20622854_ChIP-Seq_HELA_Human0.73290162
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72992184
163* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72898716
164RAC3_21632823_ChIP-Seq_H3396_Human0.71852774
165SRF_21415370_ChIP-Seq_HL-1_Mouse0.71650131
166E2F1_20622854_ChIP-Seq_HELA_Human0.71307009
167* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71053243
168SPI1_20517297_ChIP-Seq_HL60_Human0.70984644
169CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.70177779
170PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69795954
171ESR1_21235772_ChIP-Seq_MCF-7_Human0.69396877
172OCT4_20526341_ChIP-Seq_ESCs_Human0.69030053
173KDM2B_26808549_Chip-Seq_SUP-B15_Human0.68415717
174GATA6_25053715_ChIP-Seq_YYC3_Human0.68317951
175RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68002501
176ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.68001877
177AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67993163
178UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.67452992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.72606984
2MP0003646_muscle_fatigue4.35961152
3MP0004084_abnormal_cardiac_muscle3.96371277
4MP0000751_myopathy3.77526265
5MP0004215_abnormal_myocardial_fiber3.31132773
6MP0004036_abnormal_muscle_relaxation3.28143618
7MP0000749_muscle_degeneration3.09738910
8MP0002139_abnormal_hepatobiliary_system3.06524807
9MP0005330_cardiomyopathy3.00273828
10MP0004130_abnormal_muscle_cell2.96227825
11MP0008058_abnormal_DNA_repair2.92440838
12MP0005360_urolithiasis2.82220582
13MP0001529_abnormal_vocalization2.75531020
14MP0006036_abnormal_mitochondrial_physio2.52322386
15MP0003880_abnormal_central_pattern2.50026824
16MP0004087_abnormal_muscle_fiber2.45361164
17MP0003806_abnormal_nucleotide_metabolis2.44302529
18MP0000372_irregular_coat_pigmentation2.39045651
19MP0005085_abnormal_gallbladder_physiolo2.37122187
20MP0005365_abnormal_bile_salt2.33264273
21MP0002269_muscular_atrophy2.25507662
22MP0002972_abnormal_cardiac_muscle2.23880975
23MP0004043_abnormal_pH_regulation2.23152383
24MP0005670_abnormal_white_adipose2.11190100
25MP0005620_abnormal_muscle_contractility2.11183287
26MP0000750_abnormal_muscle_regeneration2.10284533
27MP0000747_muscle_weakness2.08106924
28MP0008775_abnormal_heart_ventricle2.07850434
29MP0003195_calcinosis2.02772359
30MP0005666_abnormal_adipose_tissue2.02764380
31MP0004145_abnormal_muscle_electrophysio1.95438218
32MP0002102_abnormal_ear_morphology1.90761479
33MP0002106_abnormal_muscle_physiology1.85637731
34MP0005385_cardiovascular_system_phenoty1.85607837
35MP0001544_abnormal_cardiovascular_syste1.85607837
36MP0005332_abnormal_amino_acid1.81404111
37MP0003137_abnormal_impulse_conducting1.81274926
38MP0010630_abnormal_cardiac_muscle1.80694563
39MP0008789_abnormal_olfactory_epithelium1.79259203
40MP0009840_abnormal_foam_cell1.77554349
41MP0002822_catalepsy1.74398860
42MP0003221_abnormal_cardiomyocyte_apopto1.71687512
43MP0003011_delayed_dark_adaptation1.71345763
44MP0006138_congestive_heart_failure1.70949985
45MP0004233_abnormal_muscle_weight1.69473032
46MP0003693_abnormal_embryo_hatching1.67406196
47MP0000013_abnormal_adipose_tissue1.67185788
48MP0000759_abnormal_skeletal_muscle1.66971679
49MP0008932_abnormal_embryonic_tissue1.65302590
50MP0010094_abnormal_chromosome_stability1.64480301
51MP0006276_abnormal_autonomic_nervous1.61673606
52MP0010329_abnormal_lipoprotein_level1.59116401
53MP0002909_abnormal_adrenal_gland1.57368242
54MP0003705_abnormal_hypodermis_morpholog1.56156670
55MP0004270_analgesia1.53238549
56MP0004484_altered_response_of1.52429749
57MP0008875_abnormal_xenobiotic_pharmacok1.52393265
58MP0001984_abnormal_olfaction1.50497980
59MP0005369_muscle_phenotype1.49442729
60MP0003252_abnormal_bile_duct1.48933541
61MP0005423_abnormal_somatic_nervous1.47784943
62MP0005083_abnormal_biliary_tract1.47757854
63MP0004185_abnormal_adipocyte_glucose1.46574422
64MP0005375_adipose_tissue_phenotype1.46114197
65MP0005394_taste/olfaction_phenotype1.43422561
66MP0005499_abnormal_olfactory_system1.43422561
67MP0003718_maternal_effect1.42417935
68MP0002736_abnormal_nociception_after1.41830146
69MP0004085_abnormal_heartbeat1.40216482
70MP0006035_abnormal_mitochondrial_morpho1.37472989
71MP0002118_abnormal_lipid_homeostasis1.35488447
72MP0002078_abnormal_glucose_homeostasis1.35263053
73MP0003111_abnormal_nucleus_morphology1.34977367
74MP0010030_abnormal_orbit_morphology1.34928598
75MP0005319_abnormal_enzyme/_coenzyme1.30304059
76MP0009643_abnormal_urine_homeostasis1.30292470
77MP0008007_abnormal_cellular_replicative1.27680334
78MP0004957_abnormal_blastocyst_morpholog1.27082801
79MP0003122_maternal_imprinting1.25652209
80MP0002971_abnormal_brown_adipose1.24735027
81MP0002332_abnormal_exercise_endurance1.21961379
82MP0002938_white_spotting1.21350972
83MP0003786_premature_aging1.20473962
84MP0001666_abnormal_nutrient_absorption1.19708242
85MP0005584_abnormal_enzyme/coenzyme_acti1.17147775
86MP0006072_abnormal_retinal_apoptosis1.16548669
87MP0005253_abnormal_eye_physiology1.16150957
88MP0000003_abnormal_adipose_tissue1.15219941
89MP0009780_abnormal_chondrocyte_physiolo1.13337048
90MP0005266_abnormal_metabolism1.10377365
91MP0003077_abnormal_cell_cycle1.08084619
92MP0005535_abnormal_body_temperature1.05926780
93MP0002638_abnormal_pupillary_reflex1.05467665
94MP0003191_abnormal_cellular_cholesterol1.04670885
95MP0000609_abnormal_liver_physiology1.04422685
96MP0005171_absent_coat_pigmentation1.04419233
97MP0002234_abnormal_pharynx_morphology1.04298041
98MP0009697_abnormal_copulation1.04181945
99MP0000358_abnormal_cell_content/1.03042515
100MP0001661_extended_life_span1.01573076
101MP0000230_abnormal_systemic_arterial1.01303070
102MP0003283_abnormal_digestive_organ1.00131974
103MP0008961_abnormal_basal_metabolism0.97421476
104MP0002751_abnormal_autonomic_nervous0.96680520
105MP0002877_abnormal_melanocyte_morpholog0.95925152
106MP0001756_abnormal_urination0.94287035
107MP0009046_muscle_twitch0.94176190
108MP0008995_early_reproductive_senescence0.93737386
109MP0002127_abnormal_cardiovascular_syste0.92690182
110MP0003828_pulmonary_edema0.90026222
111MP0005248_abnormal_Harderian_gland0.89721461
112MP0005075_abnormal_melanosome_morpholog0.87151126
113MP0001905_abnormal_dopamine_level0.85740570
114MP0001765_abnormal_ion_homeostasis0.85565759
115MP0005165_increased_susceptibility_to0.84839755
116MP0005408_hypopigmentation0.83247352
117MP0005451_abnormal_body_composition0.81843654
118MP0004142_abnormal_muscle_tone0.80355944
119MP0000647_abnormal_sebaceous_gland0.79155543
120MP0000266_abnormal_heart_morphology0.76584532
121MP0002090_abnormal_vision0.75860405
122MP0005636_abnormal_mineral_homeostasis0.75841831
123MP0008260_abnormal_autophagy0.75755351
124MP0001727_abnormal_embryo_implantation0.75612342
125MP0002272_abnormal_nervous_system0.73851631
126MP0005334_abnormal_fat_pad0.73623303
127MP0001346_abnormal_lacrimal_gland0.72813843
128MP0006292_abnormal_olfactory_placode0.71722550
129MP0005551_abnormal_eye_electrophysiolog0.70925089
130MP0008438_abnormal_cutaneous_collagen0.69917249
131MP0010368_abnormal_lymphatic_system0.68775516
132MP0001944_abnormal_pancreas_morphology0.68361223
133MP0003186_abnormal_redox_activity0.68318442
134MP0002693_abnormal_pancreas_physiology0.66429971
135MP0005646_abnormal_pituitary_gland0.66317893
136MP0005448_abnormal_energy_balance0.65171916
137MP0000343_altered_response_to0.64989144
138MP0005645_abnormal_hypothalamus_physiol0.64164873
139MP0002970_abnormal_white_adipose0.64023431
140MP0005058_abnormal_lysosome_morphology0.63924733
141MP0003329_amyloid_beta_deposits0.63633455
142MP0003566_abnormal_cell_adhesion0.63589851
143MP0001764_abnormal_homeostasis0.62604727
144MP0003953_abnormal_hormone_level0.62520922
145MP0002108_abnormal_muscle_morphology0.61925378
146MP0004019_abnormal_vitamin_homeostasis0.60211233
147MP0005187_abnormal_penis_morphology0.57420937
148MP0003567_abnormal_fetal_cardiomyocyte0.57340969
149MP0004147_increased_porphyrin_level0.56430081
150MP0003959_abnormal_lean_body0.55164445
151MP0009642_abnormal_blood_homeostasis0.54891657
152MP0002138_abnormal_hepatobiliary_system0.54285331
153MP0000598_abnormal_liver_morphology0.53013117

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)5.44919782
2Sudden death (HP:0001699)4.91345952
3Hypoglycemic coma (HP:0001325)4.90788542
4Exercise-induced myalgia (HP:0003738)4.83164921
5Exercise-induced muscle cramps (HP:0003710)4.75606856
6Nemaline bodies (HP:0003798)4.63913779
7Ketoacidosis (HP:0001993)4.54325584
8Rhabdomyolysis (HP:0003201)4.13673485
9Ventricular tachycardia (HP:0004756)4.11023791
10Calf muscle hypertrophy (HP:0008981)3.95723817
11Ketosis (HP:0001946)3.93637103
12Abnormality of fatty-acid metabolism (HP:0004359)3.79759661
13Muscle hypertrophy of the lower extremities (HP:0008968)3.69825671
14Palpitations (HP:0001962)3.66468447
15Muscle fiber splitting (HP:0003555)3.64803676
16Abnormal gallbladder physiology (HP:0012438)3.59042243
17Cholecystitis (HP:0001082)3.59042243
18Hepatic necrosis (HP:0002605)3.56970913
19Dicarboxylic aciduria (HP:0003215)3.51275691
20Abnormality of dicarboxylic acid metabolism (HP:0010995)3.51275691
21Hyperglycinuria (HP:0003108)3.37716373
22Right ventricular cardiomyopathy (HP:0011663)3.30852938
23Hyporeflexia of lower limbs (HP:0002600)3.30613273
24Hyperammonemia (HP:0001987)3.29792592
25Hyperinsulinemic hypoglycemia (HP:0000825)3.27213142
26Lipoatrophy (HP:0100578)3.25648641
27Asymmetric septal hypertrophy (HP:0001670)3.24609988
28Generalized aminoaciduria (HP:0002909)3.23014287
29Microvesicular hepatic steatosis (HP:0001414)3.21734111
30* Exercise intolerance (HP:0003546)3.18760669
31Atrial fibrillation (HP:0005110)3.17742415
32Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17495622
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17495622
34Abnormality of the calf musculature (HP:0001430)3.14406289
35Abnormality of the left ventricular outflow tract (HP:0011103)3.08735303
36Subaortic stenosis (HP:0001682)3.08735303
37Increased serum lactate (HP:0002151)3.08700986
38Bundle branch block (HP:0011710)3.08051841
39Dilated cardiomyopathy (HP:0001644)2.97864239
40Increased connective tissue (HP:0009025)2.96561389
41* Progressive macrocephaly (HP:0004481)2.95677433
42Abnormality of glycine metabolism (HP:0010895)2.95634260
43Abnormality of serine family amino acid metabolism (HP:0010894)2.95634260
44Type I transferrin isoform profile (HP:0003642)2.95313836
45Increased muscle lipid content (HP:0009058)2.94176885
46Primary atrial arrhythmia (HP:0001692)2.94147323
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93265796
48Gout (HP:0001997)2.91283614
49Difficulty running (HP:0009046)2.90024929
50Supraventricular tachycardia (HP:0004755)2.86524889
51Supraventricular arrhythmia (HP:0005115)2.82490082
52EMG: myopathic abnormalities (HP:0003458)2.82122050
53Lipid accumulation in hepatocytes (HP:0006561)2.81271835
54Syncope (HP:0001279)2.79522675
55Rimmed vacuoles (HP:0003805)2.76486065
56Hepatocellular necrosis (HP:0001404)2.74926665
57Increased hepatocellular lipid droplets (HP:0006565)2.74310535
58Conjunctival hamartoma (HP:0100780)2.73905817
59Ragged-red muscle fibers (HP:0003200)2.70508039
603-Methylglutaconic aciduria (HP:0003535)2.65003768
61* Respiratory failure (HP:0002878)2.64250112
62Pheochromocytoma (HP:0002666)2.63509301
63Muscle stiffness (HP:0003552)2.62402846
64Ventricular arrhythmia (HP:0004308)2.60613055
65Myopathic facies (HP:0002058)2.60013074
66* Cerebral edema (HP:0002181)2.59974277
67Atrioventricular block (HP:0001678)2.59813080
68Hypoglycemic seizures (HP:0002173)2.59683149
69Abnormality of serum amino acid levels (HP:0003112)2.58225983
70Late onset (HP:0003584)2.57479997
71Heart block (HP:0012722)2.56715646
72CNS demyelination (HP:0007305)2.55228832
73Myotonia (HP:0002486)2.54319668
74* Abnormal mitochondria in muscle tissue (HP:0008316)2.49553918
75Prolonged QT interval (HP:0001657)2.48141021
76* Acute encephalopathy (HP:0006846)2.44978494
77Emotional lability (HP:0000712)2.43909311
78Degeneration of anterior horn cells (HP:0002398)2.43814834
79Abnormality of the anterior horn cell (HP:0006802)2.43814834
80Metabolic acidosis (HP:0001942)2.42099655
81Increased serum pyruvate (HP:0003542)2.39994991
82Abnormality of glycolysis (HP:0004366)2.39994991
83Abnormal atrioventricular conduction (HP:0005150)2.39994453
84Ventricular fibrillation (HP:0001663)2.39762353
85Type 1 muscle fiber predominance (HP:0003803)2.38683871
86* Lactic acidosis (HP:0003128)2.37007208
87Hyperglycinemia (HP:0002154)2.36773804
88Neuroendocrine neoplasm (HP:0100634)2.36624177
89Proximal tubulopathy (HP:0000114)2.34475554
90Increased intramyocellular lipid droplets (HP:0012240)2.34293000
91Xanthomatosis (HP:0000991)2.33324796
92Difficulty climbing stairs (HP:0003551)2.31813667
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31539413
94Abnormal protein N-linked glycosylation (HP:0012347)2.31539413
95Abnormal protein glycosylation (HP:0012346)2.31539413
96Abnormal glycosylation (HP:0012345)2.31539413
97Muscle fiber inclusion bodies (HP:0100299)2.30622945
98Abnormal gallbladder morphology (HP:0012437)2.30589097
99Hyperglycemia (HP:0003074)2.29977120
100Abnormality of alanine metabolism (HP:0010916)2.25145395
101Hyperalaninemia (HP:0003348)2.25145395
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25145395
103Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23197185
104Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.22922561
105Neoplasm of the adrenal gland (HP:0100631)2.22239445
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21437040
107* Lethargy (HP:0001254)2.20644684
108Reduced antithrombin III activity (HP:0001976)2.20465498
109Hypoalphalipoproteinemia (HP:0003233)2.18264339
110Distal arthrogryposis (HP:0005684)2.16457236
111Increased purine levels (HP:0004368)2.15202618
112Hyperuricemia (HP:0002149)2.15202618
113Cerebral hypomyelination (HP:0006808)2.15115681
114* Acute necrotizing encephalopathy (HP:0006965)2.14065808
115Abnormality of methionine metabolism (HP:0010901)2.13926608
116Abnormality of purine metabolism (HP:0004352)2.13507703
117* Increased CSF lactate (HP:0002490)2.10528997
118Limb-girdle muscle atrophy (HP:0003797)2.07803053
119Multiple enchondromatosis (HP:0005701)2.07802767
120Esophageal neoplasm (HP:0100751)2.06799075
121Neoplasm of head and neck (HP:0012288)2.06799075
122Cholelithiasis (HP:0001081)2.06337986
123Pancreatic islet-cell hyperplasia (HP:0004510)2.04722119
124Increased variability in muscle fiber diameter (HP:0003557)2.04337415
125Neck muscle weakness (HP:0000467)2.03190757
126Hamartoma of the eye (HP:0010568)2.02085632
127Skin nodule (HP:0200036)2.00745229
128Large for gestational age (HP:0001520)2.00186906
129Intrahepatic cholestasis (HP:0001406)1.99904910
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99728586
131* Mitochondrial inheritance (HP:0001427)1.98584586
132Nausea (HP:0002018)1.97614970
133Cortical dysplasia (HP:0002539)1.97424541
134* Vomiting (HP:0002013)1.97214211
135Abnormality of the labia minora (HP:0012880)1.96982218
136Cerebral palsy (HP:0100021)1.96796110
137Progressive muscle weakness (HP:0003323)1.96337549
138Renal Fanconi syndrome (HP:0001994)1.93308669
139Centrally nucleated skeletal muscle fibers (HP:0003687)1.89670543
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83642384
141CNS hypomyelination (HP:0003429)1.83025617
142Methylmalonic aciduria (HP:0012120)1.82544554
143Methylmalonic acidemia (HP:0002912)1.80249940
144Calcaneovalgus deformity (HP:0001848)1.80112023
145Poor suck (HP:0002033)1.78921066
146Type 2 muscle fiber atrophy (HP:0003554)1.78503307
147* Optic disc pallor (HP:0000543)1.76863468
148Oligomenorrhea (HP:0000876)1.73854049
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.73692188
150Shoulder girdle muscle weakness (HP:0003547)1.73206452
151Delayed CNS myelination (HP:0002188)1.71696515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.93671119
2TRIB34.39082430
3TTN4.38890548
4PDK33.87943019
5PDK43.87943019
6PKN23.56869832
7VRK23.36106981
8NEK13.27523410
9BUB13.18394411
10OBSCN3.17497272
11LMTK23.10256314
12PHKG22.97859595
13PHKG12.97859595
14SRPK12.51289520
15PBK2.47570426
16TESK22.44339238
17INSRR2.30997060
18MYLK2.20418030
19TRIM282.17611695
20PDK22.07610557
21LIMK11.94544355
22FLT31.90103133
23EIF2AK11.88887544
24ERN11.88657833
25STK161.86768101
26TSSK61.81755133
27TESK11.77112093
28WNK41.75453304
29PINK11.74445004
30CSNK1G31.65805814
31SIK11.62401649
32MARK11.61878437
33DYRK21.56442372
34BCR1.53315930
35CCNB11.49512776
36TTK1.40878899
37TIE11.40600954
38PRKD31.40089054
39ZAK1.39748819
40MAP2K71.34912650
41PLK31.34325190
42DMPK1.32783021
43CSNK1G21.31077234
44CSNK1A1L1.29263640
45RIPK11.27847484
46CSNK1G11.27248562
47PDGFRA1.23446269
48PIK3CA1.14852682
49VRK11.13160809
50PAK31.11219338
51MAPKAPK31.10917817
52SCYL21.09193224
53PTK61.09063351
54EIF2AK31.08349972
55ERBB31.08094388
56MAP3K71.07758648
57MAP4K21.01096761
58MAP2K30.98956227
59DAPK10.98372260
60MKNK10.97016400
61MAP3K120.96247222
62PLK20.95577328
63SIK30.94676669
64ILK0.94091181
65EPHA40.92970320
66MAPK130.91230964
67PRKAA10.91112470
68CDK190.90282910
69PIM20.89321399
70PLK10.87345449
71FGFR40.83847329
72PRKD10.83718891
73KDR0.81698481
74MAP3K30.80648618
75MINK10.77456137
76PRKAA20.77230037
77PIK3CG0.76510617
78RPS6KA40.76004523
79KSR20.75103217
80CAMK2D0.73894298
81NME10.73440348
82WEE10.71568990
83NUAK10.69521568
84CDC70.68996296
85BRSK10.68733658
86MUSK0.68148929
87PLK40.67871938
88LRRK20.67228972
89AURKB0.65711738
90STK240.64521628
91CDC42BPA0.64282947
92MAP3K100.63448061
93PAK60.63057397
94MAPK120.61247738
95STK38L0.61243672
96ARAF0.60235411
97MAP2K40.60195132
98MST40.60142662
99CDK140.60124345
100CDK180.59892553
101MAPK110.58445141
102ATR0.57825435
103EEF2K0.57778934
104CSNK2A10.57203833
105PDPK10.56488101
106CAMK2B0.55927448
107DAPK30.55735991
108PASK0.54787301
109MAP3K10.53877341
110NEK90.53599458
111MAP3K20.52832181
112ERBB40.52547123
113WNK30.52507061
114CDK150.52432493
115MET0.51997110
116AURKA0.51880690
117RET0.51656510
118UHMK10.51459583
119STK380.51445720
120CDK11A0.51325149
121CAMK2A0.51256771
122MAPKAPK50.51208631
123PRKCH0.51180211
124PRKACG0.50177577
125ALK0.49932005
126ROCK10.49811964
127MAP2K10.48796047
128MAP3K50.48614495
129CAMK1D0.47228365
130CSNK2A20.47094796
131PDK10.44771918
132FER0.44569777
133CAMK2G0.43470389
134MAP3K110.42867053
135JAK20.42865951
136CSNK1A10.41691476
137AKT20.40751805
138RPS6KA50.40075319
139PAK10.39491802
140DYRK30.39049492
141PRKCG0.38416363
142PRKCE0.36131410
143MST1R0.36115006
144CAMK40.34748293
145NTRK10.33537877
146EPHB20.33083076
147CAMKK20.33004329
148EIF2AK20.32247982
149CSNK1E0.30847608
150PTK20.30161666
151PRKACA0.30008008
152NME20.29661636
153CAMKK10.29630844
154MTOR0.28243418
155DYRK1B0.27727756
156PRKG20.26832749
157PRKACB0.26557537
158MAP2K60.26550395
159EPHB10.23787494
160ICK0.23715126
161TGFBR20.23653673
162EPHA30.22480864
163MAP3K40.21644795
164TAOK10.19594365
165WNK10.19153015
166JAK10.19129872
167CAMK10.18905581
168FRK0.18512268
169ABL20.18468757
170SGK30.18367400
171PAK40.18364542

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.58495790
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.24410323
3Propanoate metabolism_Homo sapiens_hsa006403.65348567
4Proteasome_Homo sapiens_hsa030503.61666287
5Fatty acid degradation_Homo sapiens_hsa000713.40805005
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30220478
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.24928454
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79217579
9Carbon metabolism_Homo sapiens_hsa012002.71318420
10Fatty acid metabolism_Homo sapiens_hsa012122.62669731
11Pyruvate metabolism_Homo sapiens_hsa006202.49005691
12Butanoate metabolism_Homo sapiens_hsa006502.42540679
13Cardiac muscle contraction_Homo sapiens_hsa042601.96401783
14Tryptophan metabolism_Homo sapiens_hsa003801.95210374
15Parkinsons disease_Homo sapiens_hsa050121.79537377
16* Oxidative phosphorylation_Homo sapiens_hsa001901.78953568
17Biosynthesis of amino acids_Homo sapiens_hsa012301.73648186
18PPAR signaling pathway_Homo sapiens_hsa033201.72278064
19Nitrogen metabolism_Homo sapiens_hsa009101.71361864
20Arginine biosynthesis_Homo sapiens_hsa002201.71134099
21Base excision repair_Homo sapiens_hsa034101.66159746
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65862110
23Mismatch repair_Homo sapiens_hsa034301.53894612
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53446319
25Protein export_Homo sapiens_hsa030601.51426166
26beta-Alanine metabolism_Homo sapiens_hsa004101.46947794
27DNA replication_Homo sapiens_hsa030301.45561700
28Fatty acid elongation_Homo sapiens_hsa000621.44191461
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.43390223
30Peroxisome_Homo sapiens_hsa041461.43379030
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42622244
32RNA polymerase_Homo sapiens_hsa030201.41786463
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.39831520
34Sulfur metabolism_Homo sapiens_hsa009201.38515706
35Non-homologous end-joining_Homo sapiens_hsa034501.35298745
36Starch and sucrose metabolism_Homo sapiens_hsa005001.33621565
37Dilated cardiomyopathy_Homo sapiens_hsa054141.33591096
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31865594
39* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30311424
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28089449
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27189171
42Alzheimers disease_Homo sapiens_hsa050101.25802173
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18643375
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14822493
45One carbon pool by folate_Homo sapiens_hsa006701.11434929
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08625510
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06851797
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06146619
49Phenylalanine metabolism_Homo sapiens_hsa003601.05444504
50Ribosome_Homo sapiens_hsa030101.02570966
51Spliceosome_Homo sapiens_hsa030401.01604877
52Pyrimidine metabolism_Homo sapiens_hsa002401.01405129
53Selenocompound metabolism_Homo sapiens_hsa004501.00613549
54Glucagon signaling pathway_Homo sapiens_hsa049220.99249335
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98492738
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.97229905
57Fat digestion and absorption_Homo sapiens_hsa049750.97110608
58Galactose metabolism_Homo sapiens_hsa000520.96262076
59Insulin resistance_Homo sapiens_hsa049310.96019685
60Huntingtons disease_Homo sapiens_hsa050160.94493404
61Arginine and proline metabolism_Homo sapiens_hsa003300.91472172
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.86675908
63Bile secretion_Homo sapiens_hsa049760.85938686
64Fructose and mannose metabolism_Homo sapiens_hsa000510.85053137
65RNA transport_Homo sapiens_hsa030130.84558107
66Collecting duct acid secretion_Homo sapiens_hsa049660.84042244
67Purine metabolism_Homo sapiens_hsa002300.82132049
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79471276
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78671342
70Homologous recombination_Homo sapiens_hsa034400.76827501
71Lysine degradation_Homo sapiens_hsa003100.76804002
72Nucleotide excision repair_Homo sapiens_hsa034200.76524024
73Steroid biosynthesis_Homo sapiens_hsa001000.73815923
74RNA degradation_Homo sapiens_hsa030180.72985090
75Pentose phosphate pathway_Homo sapiens_hsa000300.71880770
76Fanconi anemia pathway_Homo sapiens_hsa034600.70143110
77Fatty acid biosynthesis_Homo sapiens_hsa000610.69791075
78Tyrosine metabolism_Homo sapiens_hsa003500.69773767
79Insulin signaling pathway_Homo sapiens_hsa049100.69452522
80AMPK signaling pathway_Homo sapiens_hsa041520.69023907
81Glycerolipid metabolism_Homo sapiens_hsa005610.64675845
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64433471
83Vitamin B6 metabolism_Homo sapiens_hsa007500.59151999
84Folate biosynthesis_Homo sapiens_hsa007900.56599102
85* Metabolic pathways_Homo sapiens_hsa011000.48015284
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.47097095
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47057485
88Type II diabetes mellitus_Homo sapiens_hsa049300.45448010
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.44794438
90Sulfur relay system_Homo sapiens_hsa041220.44724631
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44346040
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.44009054
93Caffeine metabolism_Homo sapiens_hsa002320.43410718
94Insulin secretion_Homo sapiens_hsa049110.43198658
95ABC transporters_Homo sapiens_hsa020100.42742222
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42283890
97Synaptic vesicle cycle_Homo sapiens_hsa047210.42273865
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41740933
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41551330
100Oocyte meiosis_Homo sapiens_hsa041140.40556225
101Histidine metabolism_Homo sapiens_hsa003400.38890333
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38828096
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34276527
104Glutathione metabolism_Homo sapiens_hsa004800.32765763
105Chemical carcinogenesis_Homo sapiens_hsa052040.32663218
106Complement and coagulation cascades_Homo sapiens_hsa046100.31937625
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30897505
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30852631
109N-Glycan biosynthesis_Homo sapiens_hsa005100.30608896
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29689146
111Basal transcription factors_Homo sapiens_hsa030220.28906569
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.28214502
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25161415
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24947731
115Cell cycle_Homo sapiens_hsa041100.24514227
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24273802
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22462393
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22456425
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19428883
120Phototransduction_Homo sapiens_hsa047440.16488738
121HIF-1 signaling pathway_Homo sapiens_hsa040660.14769103
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13871713
123Viral myocarditis_Homo sapiens_hsa054160.12665803
124Gastric acid secretion_Homo sapiens_hsa049710.07996794
125Retinol metabolism_Homo sapiens_hsa008300.07755428
126Thyroid hormone synthesis_Homo sapiens_hsa049180.06995686
127Pancreatic secretion_Homo sapiens_hsa049720.06195199
128Circadian rhythm_Homo sapiens_hsa047100.05469591
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05221608
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.04406575
131Vibrio cholerae infection_Homo sapiens_hsa051100.04171042
132mTOR signaling pathway_Homo sapiens_hsa041500.03923243

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