NDUFS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.23969008
2ATP synthesis coupled proton transport (GO:0015986)8.84354423
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.84354423
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.37979872
5* respiratory electron transport chain (GO:0022904)7.57196665
6* electron transport chain (GO:0022900)7.40328817
7translational termination (GO:0006415)6.49017266
8ribosomal small subunit assembly (GO:0000028)6.01147676
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.89242371
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.55872269
11chaperone-mediated protein transport (GO:0072321)5.53765244
12maturation of SSU-rRNA (GO:0030490)5.48610155
13translational elongation (GO:0006414)5.44253246
14protein localization to endoplasmic reticulum (GO:0070972)5.43958434
15establishment of protein localization to mitochondrial membrane (GO:0090151)5.40449625
16cellular protein complex disassembly (GO:0043624)5.03202971
17viral life cycle (GO:0019058)4.95935367
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.91144693
19protein neddylation (GO:0045116)4.84383498
20translational initiation (GO:0006413)4.83541464
21ATP biosynthetic process (GO:0006754)4.81791367
22ribosomal large subunit biogenesis (GO:0042273)4.77971592
23hydrogen ion transmembrane transport (GO:1902600)4.76151952
24inner mitochondrial membrane organization (GO:0007007)4.59288906
25purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.48747097
26translation (GO:0006412)4.45664359
27purine nucleoside triphosphate biosynthetic process (GO:0009145)4.41128165
28protein complex disassembly (GO:0043241)4.32074144
29* protein complex biogenesis (GO:0070271)4.30680008
30proton transport (GO:0015992)4.23048904
31axon ensheathment in central nervous system (GO:0032291)4.20821362
32central nervous system myelination (GO:0022010)4.20821362
33hydrogen transport (GO:0006818)4.15537467
34macromolecular complex disassembly (GO:0032984)4.13757776
35termination of RNA polymerase III transcription (GO:0006386)4.06570131
36transcription elongation from RNA polymerase III promoter (GO:0006385)4.06570131
37* mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99811232
38* mitochondrial respiratory chain complex I assembly (GO:0032981)3.99811232
39* NADH dehydrogenase complex assembly (GO:0010257)3.99811232
40oxidative phosphorylation (GO:0006119)3.94078751
41protein targeting to membrane (GO:0006612)3.91785242
42* mitochondrial respiratory chain complex assembly (GO:0033108)3.90974729
43ribonucleoside triphosphate biosynthetic process (GO:0009201)3.89517069
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.69235900
45establishment of integrated proviral latency (GO:0075713)3.65652467
46nuclear-transcribed mRNA catabolic process (GO:0000956)3.64577604
47* cellular component biogenesis (GO:0044085)3.62063521
48ribonucleoprotein complex biogenesis (GO:0022613)3.61489386
49fatty acid elongation (GO:0030497)3.60308855
50ATP hydrolysis coupled proton transport (GO:0015991)3.57264814
51energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.57264814
52substantia nigra development (GO:0021762)3.52747287
53mRNA catabolic process (GO:0006402)3.44467323
54spliceosomal snRNP assembly (GO:0000387)3.43231270
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42828035
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41090235
57negative regulation of ligase activity (GO:0051352)3.41090235
58regulation of oxidative phosphorylation (GO:0002082)3.40285767
59chromatin remodeling at centromere (GO:0031055)3.40002581
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37690853
61rRNA modification (GO:0000154)3.35618856
62nucleoside triphosphate biosynthetic process (GO:0009142)3.34528855
63dopamine transport (GO:0015872)3.34417161
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33583150
65GTP biosynthetic process (GO:0006183)3.33092153
66CENP-A containing nucleosome assembly (GO:0034080)3.32151365
67long-chain fatty acid biosynthetic process (GO:0042759)3.29809810
68pseudouridine synthesis (GO:0001522)3.29440404
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29235192
70protein targeting to mitochondrion (GO:0006626)3.24939631
71establishment of protein localization to mitochondrion (GO:0072655)3.22558941
72rRNA processing (GO:0006364)3.22392151
73neuron cell-cell adhesion (GO:0007158)3.21105845
74mitochondrial transport (GO:0006839)3.18914759
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18316314
76RNA catabolic process (GO:0006401)3.18202926
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15442904
78regulation of catecholamine metabolic process (GO:0042069)3.11923615
79regulation of dopamine metabolic process (GO:0042053)3.11923615
80DNA damage response, detection of DNA damage (GO:0042769)3.11376349
81calcium-mediated signaling using intracellular calcium source (GO:0035584)3.10988949
82rRNA metabolic process (GO:0016072)3.08261717
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06592393
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06592393
85intracellular protein transmembrane import (GO:0044743)3.03602789
86protein localization to mitochondrion (GO:0070585)3.00667734
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95565048
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95350839
89regulation of mitochondrial translation (GO:0070129)2.94830482
90sequestering of actin monomers (GO:0042989)2.93825786
91respiratory chain complex IV assembly (GO:0008535)2.92610269
927-methylguanosine mRNA capping (GO:0006370)2.91816056
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90548502
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90548502
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90548502
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88397168
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88397168
98protein targeting (GO:0006605)2.88255241
99dopamine biosynthetic process (GO:0042416)2.87662753
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86827801
101establishment of viral latency (GO:0019043)2.86475855
1027-methylguanosine RNA capping (GO:0009452)2.84136129
103RNA capping (GO:0036260)2.84136129
104neuronal action potential propagation (GO:0019227)2.81395548
105regulation of cellular respiration (GO:0043457)2.81372188
106proteasome assembly (GO:0043248)2.78427437
107* generation of precursor metabolites and energy (GO:0006091)2.78074191
108aerobic respiration (GO:0009060)2.75579756
109ribosomal small subunit biogenesis (GO:0042274)2.71922968
110cytochrome complex assembly (GO:0017004)2.68520431
111regulation of protein kinase A signaling (GO:0010738)2.67811223
112regulation of glutamate secretion (GO:0014048)2.67650381
113presynaptic membrane organization (GO:0097090)2.62978433
114UTP biosynthetic process (GO:0006228)2.61766075
115negative regulation of protein localization to cell surface (GO:2000009)2.61622625
116presynaptic membrane assembly (GO:0097105)2.59317459
117neurotransmitter uptake (GO:0001504)2.58960158
118synaptic vesicle exocytosis (GO:0016079)2.54742005
119mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.51867785
120purine nucleoside monophosphate biosynthetic process (GO:0009127)2.51856380
121purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.51856380
122transferrin transport (GO:0033572)2.50211211
123cholesterol biosynthetic process (GO:0006695)2.47697312
124regulation of cell communication by electrical coupling (GO:0010649)2.47577759
125nucleoside diphosphate phosphorylation (GO:0006165)2.44000343
126tricarboxylic acid cycle (GO:0006099)2.43271231
127neural nucleus development (GO:0048857)2.42518289
128purine nucleoside biosynthetic process (GO:0042451)2.40988187
129purine ribonucleoside biosynthetic process (GO:0046129)2.40988187
130quinone biosynthetic process (GO:1901663)2.40419882
131ubiquinone biosynthetic process (GO:0006744)2.40419882
132cullin deneddylation (GO:0010388)2.39739978
133ubiquinone metabolic process (GO:0006743)2.38481086
134intracellular protein transmembrane transport (GO:0065002)2.38373674
135guanosine-containing compound biosynthetic process (GO:1901070)2.37698109
136detection of calcium ion (GO:0005513)2.37393131
137protein-cofactor linkage (GO:0018065)2.34786789
138cotranslational protein targeting to membrane (GO:0006613)2.33937369
139transmission of nerve impulse (GO:0019226)2.33294045
140response to redox state (GO:0051775)2.31903339
141response to epinephrine (GO:0071871)2.31887740
142negative regulation of neurotransmitter transport (GO:0051589)2.31506813
143regulation of cellular amino acid metabolic process (GO:0006521)2.30549118
144UTP metabolic process (GO:0046051)2.30310583
145ferric iron transport (GO:0015682)2.28785510
146trivalent inorganic cation transport (GO:0072512)2.28785510
147viral transcription (GO:0019083)2.28501183
148establishment of mitochondrion localization (GO:0051654)2.28020502
149cellular response to epinephrine stimulus (GO:0071872)2.27774876
150negative regulation of microtubule polymerization (GO:0031115)2.27734803
151protein localization to synapse (GO:0035418)2.26024009
152succinate metabolic process (GO:0006105)2.25474195
153protein targeting to ER (GO:0045047)2.24975542
154synaptic transmission, dopaminergic (GO:0001963)2.24872467
155positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.24763717
156protein localization to cilium (GO:0061512)2.24467351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.31163195
2EZH2_22144423_ChIP-Seq_EOC_Human3.96896541
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.85079137
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05174328
5* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90538497
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79767674
7E2F7_22180533_ChIP-Seq_HELA_Human2.68061281
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65996381
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64770288
10GBX2_23144817_ChIP-Seq_PC3_Human2.63135624
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59420454
12* ELK1_19687146_ChIP-ChIP_HELA_Human2.55092182
13* XRN2_22483619_ChIP-Seq_HELA_Human2.54947132
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54705982
15* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.45804362
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.39699218
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37225099
18TTF2_22483619_ChIP-Seq_HELA_Human2.35568731
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32653655
20VDR_22108803_ChIP-Seq_LS180_Human2.31008461
21TAF15_26573619_Chip-Seq_HEK293_Human2.30587102
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24162342
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23770129
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21777597
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21184645
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21142393
27VDR_23849224_ChIP-Seq_CD4+_Human2.19790318
28BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13503532
29FOXP3_21729870_ChIP-Seq_TREG_Human2.13212424
30EZH2_27304074_Chip-Seq_ESCs_Mouse2.12047339
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09898503
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08530173
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01956645
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99039873
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94676811
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92963093
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89891311
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87468234
39* EST1_17652178_ChIP-ChIP_JURKAT_Human1.86970280
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86077185
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85097145
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84889151
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.83349468
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82753282
45GABP_19822575_ChIP-Seq_HepG2_Human1.80789981
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80763852
47MYC_18940864_ChIP-ChIP_HL60_Human1.79824726
48REST_21632747_ChIP-Seq_MESCs_Mouse1.72465174
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.72307919
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72078069
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70006058
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69928057
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69928057
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69255948
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66981736
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66759482
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66631992
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65751641
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.64662251
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60794022
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.59055120
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57922163
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55442834
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.54851405
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51564490
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.49558730
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49477243
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49346601
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47181978
70FUS_26573619_Chip-Seq_HEK293_Human1.42649875
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40338217
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.40105399
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39722490
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37696723
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37529619
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36638924
77P300_19829295_ChIP-Seq_ESCs_Human1.35289513
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.33986031
79ER_23166858_ChIP-Seq_MCF-7_Human1.33074961
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32662589
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31455612
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30539697
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30160793
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29564460
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27976904
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.27108503
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26748490
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22966497
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22347454
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22265363
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.20753484
92HTT_18923047_ChIP-ChIP_STHdh_Human1.19976925
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19152189
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.18799677
95CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18598415
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18101233
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.17747937
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.16523382
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.15108560
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14312269
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13432470
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13215599
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12309357
104* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11949382
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11501918
106ZNF274_21170338_ChIP-Seq_K562_Hela1.07876500
107* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06454482
108* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06130194
109KDM5A_27292631_Chip-Seq_BREAST_Human1.04184858
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04117901
111* E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04043642
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03936538
113IRF1_19129219_ChIP-ChIP_H3396_Human1.02612847
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01622633
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00882710
116RNF2_27304074_Chip-Seq_NSC_Mouse1.00162566
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00098440
118EWS_26573619_Chip-Seq_HEK293_Human0.99844992
119IGF1R_20145208_ChIP-Seq_DFB_Human0.97310940
120AR_21909140_ChIP-Seq_LNCAP_Human0.96816976
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95970204
122ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95500655
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94878015
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93912214
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93814354
126BP1_19119308_ChIP-ChIP_Hs578T_Human0.93725449
127SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92152146
128* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92116913
129* SMAD3_21741376_ChIP-Seq_EPCs_Human0.91012582
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89451321
131CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87889482
132AR_21572438_ChIP-Seq_LNCaP_Human0.87857345
133REST_19997604_ChIP-ChIP_NEURONS_Mouse0.86895202
134SMAD4_21799915_ChIP-Seq_A2780_Human0.86472355
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86254262
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86131435
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85908956
138SOX2_19829295_ChIP-Seq_ESCs_Human0.85711117
139NANOG_19829295_ChIP-Seq_ESCs_Human0.85711117
140SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85416460
141IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85409262
142* ELK1_22589737_ChIP-Seq_MCF10A_Human0.85222447
143SOX17_20123909_ChIP-Seq_XEN_Mouse0.85056733
144* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83382948
145OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83246788
146FOXP1_21924763_ChIP-Seq_HESCs_Human0.82841776
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82833917
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82033639
149* JUN_21703547_ChIP-Seq_K562_Human0.81882994
150* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81837514
151RARB_27405468_Chip-Seq_BRAIN_Mouse0.81777905
152PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81224707
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.80823780
154MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79375305
155PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79086972
156TAL1_26923725_Chip-Seq_HPCs_Mouse0.77677003
157STAT1_20625510_ChIP-Seq_HELA_Human0.77016317
158DCP1A_22483619_ChIP-Seq_HELA_Human0.76737203
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76733099
160EOMES_21245162_ChIP-Seq_HESCs_Human0.75739695
161TP63_19390658_ChIP-ChIP_HaCaT_Human0.73229568
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72578772
163* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72428778
164FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69957519
165* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69141381
166TP53_22573176_ChIP-Seq_HFKS_Human0.67371956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.34473437
2MP0001529_abnormal_vocalization3.80051356
3MP0002837_dystrophic_cardiac_calcinosis3.49876370
4MP0006292_abnormal_olfactory_placode3.17106182
5MP0001905_abnormal_dopamine_level2.82307637
6MP0006276_abnormal_autonomic_nervous2.71720797
7MP0010030_abnormal_orbit_morphology2.67302712
8MP0008058_abnormal_DNA_repair2.63095817
9MP0009379_abnormal_foot_pigmentation2.62810802
10MP0004957_abnormal_blastocyst_morpholog2.45358120
11MP0002938_white_spotting2.41461825
12MP0003693_abnormal_embryo_hatching2.36601471
13MP0004270_analgesia2.35767547
14MP0001968_abnormal_touch/_nociception2.32817925
15MP0002272_abnormal_nervous_system2.30840330
16MP0009745_abnormal_behavioral_response2.27934075
17MP0002064_seizures2.27674978
18MP0002736_abnormal_nociception_after2.25690978
19MP0004142_abnormal_muscle_tone2.23600267
20MP0009046_muscle_twitch2.22520136
21MP0003635_abnormal_synaptic_transmissio2.15290027
22MP0001440_abnormal_grooming_behavior2.12462338
23MP0000751_myopathy2.12071779
24MP0002734_abnormal_mechanical_nocicepti2.09058691
25MP0006036_abnormal_mitochondrial_physio2.07014634
26MP0004859_abnormal_synaptic_plasticity2.03497319
27MP0001293_anophthalmia2.00221350
28MP0002735_abnormal_chemical_nociception1.92046418
29MP0005423_abnormal_somatic_nervous1.91906231
30MP0008932_abnormal_embryonic_tissue1.91296315
31MP0002572_abnormal_emotion/affect_behav1.90992510
32MP0002822_catalepsy1.88029540
33MP0003646_muscle_fatigue1.87444104
34MP0001970_abnormal_pain_threshold1.85316528
35MP0003806_abnormal_nucleotide_metabolis1.84126726
36MP0008789_abnormal_olfactory_epithelium1.81766113
37MP0001486_abnormal_startle_reflex1.79123484
38MP0010094_abnormal_chromosome_stability1.78021804
39MP0002063_abnormal_learning/memory/cond1.73082653
40MP0003718_maternal_effect1.71550029
41MP0000920_abnormal_myelination1.68706378
42MP0002733_abnormal_thermal_nociception1.66341107
43MP0003941_abnormal_skin_development1.65602161
44MP0005386_behavior/neurological_phenoty1.64376651
45MP0004924_abnormal_behavior1.64376651
46MP0003123_paternal_imprinting1.62842839
47MP0003329_amyloid_beta_deposits1.60087226
48MP0006035_abnormal_mitochondrial_morpho1.58509936
49MP0000566_synostosis1.57657770
50MP0003077_abnormal_cell_cycle1.56247399
51MP0003011_delayed_dark_adaptation1.55821137
52MP0004145_abnormal_muscle_electrophysio1.55358630
53MP0004036_abnormal_muscle_relaxation1.55070447
54MP0000749_muscle_degeneration1.54558716
55MP0002638_abnormal_pupillary_reflex1.54254171
56MP0004215_abnormal_myocardial_fiber1.53723249
57MP0002067_abnormal_sensory_capabilities1.53446253
58MP0003111_abnormal_nucleus_morphology1.52396624
59MP0005645_abnormal_hypothalamus_physiol1.51603502
60MP0004133_heterotaxia1.50082445
61MP0001501_abnormal_sleep_pattern1.50060657
62MP0005084_abnormal_gallbladder_morpholo1.49260558
63MP0003786_premature_aging1.48575898
64MP0005171_absent_coat_pigmentation1.47062145
65MP0001984_abnormal_olfaction1.44219161
66MP0006072_abnormal_retinal_apoptosis1.43683575
67MP0005409_darkened_coat_color1.43108583
68MP0003136_yellow_coat_color1.41710762
69MP0000049_abnormal_middle_ear1.39217944
70MP0005394_taste/olfaction_phenotype1.37585178
71MP0005499_abnormal_olfactory_system1.37585178
72MP0008995_early_reproductive_senescence1.36553806
73MP0000778_abnormal_nervous_system1.32063820
74MP0003137_abnormal_impulse_conducting1.30374526
75MP0005379_endocrine/exocrine_gland_phen1.29812212
76MP0002184_abnormal_innervation1.28289779
77MP0004742_abnormal_vestibular_system1.27497939
78MP0005551_abnormal_eye_electrophysiolog1.26910127
79MP0002234_abnormal_pharynx_morphology1.26560788
80MP0001986_abnormal_taste_sensitivity1.26380610
81MP0010386_abnormal_urinary_bladder1.26188951
82MP0008007_abnormal_cellular_replicative1.25627944
83MP0003938_abnormal_ear_development1.21520617
84MP0002277_abnormal_respiratory_mucosa1.21381976
85MP0005330_cardiomyopathy1.20785867
86MP0003121_genomic_imprinting1.20311389
87MP0002233_abnormal_nose_morphology1.19391026
88MP0008877_abnormal_DNA_methylation1.18734089
89MP0000631_abnormal_neuroendocrine_gland1.16687077
90MP0003567_abnormal_fetal_cardiomyocyte1.16507227
91MP0002229_neurodegeneration1.16194555
92MP0001188_hyperpigmentation1.15905421
93MP0003937_abnormal_limbs/digits/tail_de1.13603055
94MP0001485_abnormal_pinna_reflex1.13565760
95MP0005535_abnormal_body_temperature1.12271069
96MP0004043_abnormal_pH_regulation1.11855799
97MP0002332_abnormal_exercise_endurance1.11645739
98MP0002697_abnormal_eye_size1.11411922
99MP0009697_abnormal_copulation1.11283061
100MP0003315_abnormal_perineum_morphology1.10817696
101MP0002066_abnormal_motor_capabilities/c1.10771145
102MP0002163_abnormal_gland_morphology1.10762161
103MP0003195_calcinosis1.07263921
104MP0002876_abnormal_thyroid_physiology1.07195299
105MP0002102_abnormal_ear_morphology1.07183428
106MP0001286_abnormal_eye_development1.05716350
107MP0003122_maternal_imprinting1.04063959
108MP0003634_abnormal_glial_cell1.01983360
109MP0004085_abnormal_heartbeat1.01819655
110MP0005646_abnormal_pituitary_gland1.01603297
111MP0002882_abnormal_neuron_morphology1.01386379
112MP0001727_abnormal_embryo_implantation1.01168271
113MP0002557_abnormal_social/conspecific_i0.99916056
114MP0004084_abnormal_cardiac_muscle0.97701870
115MP0000747_muscle_weakness0.96835212
116MP0000955_abnormal_spinal_cord0.96484907
117MP0001502_abnormal_circadian_rhythm0.94160326
118MP0002210_abnormal_sex_determination0.94103929
119MP0008872_abnormal_physiological_respon0.92851100
120MP0003690_abnormal_glial_cell0.91583173
121MP0002752_abnormal_somatic_nervous0.90964274
122MP0000372_irregular_coat_pigmentation0.90809139
123MP0005620_abnormal_muscle_contractility0.90804266
124MP0004484_altered_response_of0.90446570
125MP0001299_abnormal_eye_distance/0.90293297
126MP0003950_abnormal_plasma_membrane0.90233315
127MP0001963_abnormal_hearing_physiology0.88598803
128MP0002972_abnormal_cardiac_muscle0.88312275
129MP0002106_abnormal_muscle_physiology0.87574808
130MP0004147_increased_porphyrin_level0.86584443
131MP0005408_hypopigmentation0.86362413
132MP0008569_lethality_at_weaning0.85442843
133MP0003890_abnormal_embryonic-extraembry0.83885561
134MP0000013_abnormal_adipose_tissue0.82920529
135MP0005451_abnormal_body_composition0.81956393
136MP0005253_abnormal_eye_physiology0.81639114
137MP0001346_abnormal_lacrimal_gland0.81599229
138MP0002160_abnormal_reproductive_system0.81495748
139MP0001664_abnormal_digestion0.80916751
140MP0003186_abnormal_redox_activity0.80346581
141MP0005410_abnormal_fertilization0.79850528
142MP0003119_abnormal_digestive_system0.79795484
143MP0000358_abnormal_cell_content/0.79738032
144MP0002751_abnormal_autonomic_nervous0.79326630
145MP0000579_abnormal_nail_morphology0.78508824
146MP0002653_abnormal_ependyma_morphology0.78300021
147MP0005391_vision/eye_phenotype0.77721844
148MP0005369_muscle_phenotype0.77444626
149MP0000750_abnormal_muscle_regeneration0.76169160
150MP0005195_abnormal_posterior_eye0.75363059
151MP0000026_abnormal_inner_ear0.74218440
152MP0003942_abnormal_urinary_system0.74025280
153MP0000230_abnormal_systemic_arterial0.73616763
154MP0002090_abnormal_vision0.73387711
155MP0003787_abnormal_imprinting0.73118836
156MP0003633_abnormal_nervous_system0.71942203
157MP0003631_nervous_system_phenotype0.71349942
158MP0000647_abnormal_sebaceous_gland0.71029846
159MP0003755_abnormal_palate_morphology0.69912002
160MP0001145_abnormal_male_reproductive0.69253521

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.51019145
2Abnormal mitochondria in muscle tissue (HP:0008316)6.81107774
3Mitochondrial inheritance (HP:0001427)6.39377867
4Progressive macrocephaly (HP:0004481)6.30803956
5Acute encephalopathy (HP:0006846)6.25687164
6Hepatocellular necrosis (HP:0001404)5.45240270
7Increased CSF lactate (HP:0002490)5.38153887
8Hepatic necrosis (HP:0002605)4.85056111
9Increased hepatocellular lipid droplets (HP:0006565)4.82207018
10Reticulocytopenia (HP:0001896)4.64255510
11Cerebral edema (HP:0002181)4.45484531
12Lipid accumulation in hepatocytes (HP:0006561)4.39100125
13Renal Fanconi syndrome (HP:0001994)4.38860935
14Macrocytic anemia (HP:0001972)4.21830441
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.01478357
16Increased intramyocellular lipid droplets (HP:0012240)4.01249228
17Optic disc pallor (HP:0000543)3.93745709
18Leukodystrophy (HP:0002415)3.92617425
19Respiratory failure (HP:0002878)3.86405245
20Increased serum pyruvate (HP:0003542)3.82145936
21Abnormality of glycolysis (HP:0004366)3.82145936
22Exercise intolerance (HP:0003546)3.77469800
23Lactic acidosis (HP:0003128)3.66794702
24Myokymia (HP:0002411)3.65843426
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.64559036
26Pheochromocytoma (HP:0002666)3.52466568
27Increased muscle lipid content (HP:0009058)3.52237647
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.51390398
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.51390398
30Neuroendocrine neoplasm (HP:0100634)3.44065227
313-Methylglutaconic aciduria (HP:0003535)3.37651129
32Increased serum lactate (HP:0002151)3.11829472
33Exertional dyspnea (HP:0002875)3.07919916
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.95427249
35Pallor (HP:0000980)2.90728301
36Abnormality of renal resorption (HP:0011038)2.86017205
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72956090
38X-linked dominant inheritance (HP:0001423)2.70712733
39Focal motor seizures (HP:0011153)2.70677472
40Colon cancer (HP:0003003)2.63169244
41Respiratory difficulties (HP:0002880)2.60523310
42Muscle hypertrophy of the lower extremities (HP:0008968)2.58197384
43Parakeratosis (HP:0001036)2.57962703
44Septo-optic dysplasia (HP:0100842)2.57820360
45Congenital, generalized hypertrichosis (HP:0004540)2.42434110
46CNS demyelination (HP:0007305)2.39925600
47Sensory axonal neuropathy (HP:0003390)2.39677134
48Emotional lability (HP:0000712)2.38442519
49Hypothermia (HP:0002045)2.32948252
50Calf muscle hypertrophy (HP:0008981)2.32151022
51Oral leukoplakia (HP:0002745)2.31905266
52Cerebral hemorrhage (HP:0001342)2.31447873
53Lethargy (HP:0001254)2.25937101
54Abnormality of urine glucose concentration (HP:0011016)2.22862412
55Glycosuria (HP:0003076)2.22862412
56Aplastic anemia (HP:0001915)2.22275567
57Hyperphosphaturia (HP:0003109)2.21372489
58Hyperglycinemia (HP:0002154)2.20085716
59Abnormality of the labia minora (HP:0012880)2.19424256
60Neurofibrillary tangles (HP:0002185)2.18659159
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17322973
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.17322973
63Retinal dysplasia (HP:0007973)2.16584206
64Atonic seizures (HP:0010819)2.15082603
65Pancreatic fibrosis (HP:0100732)2.10841945
66Limb dystonia (HP:0002451)2.09311663
67Abnormality of the anterior horn cell (HP:0006802)2.07813905
68Degeneration of anterior horn cells (HP:0002398)2.07813905
69Sudden death (HP:0001699)2.07147452
70Medial flaring of the eyebrow (HP:0010747)2.06706330
71Type I transferrin isoform profile (HP:0003642)2.04374275
72Congenital ichthyosiform erythroderma (HP:0007431)2.03853554
73Absent septum pellucidum (HP:0001331)2.03451339
74Myotonia (HP:0002486)2.01603528
75Gait imbalance (HP:0002141)1.96710540
76Methylmalonic acidemia (HP:0002912)1.95401470
77Microvesicular hepatic steatosis (HP:0001414)1.93364219
78Abnormal pupillary function (HP:0007686)1.92875521
79Anxiety (HP:0000739)1.91943008
80Methylmalonic aciduria (HP:0012120)1.89871111
81Abnormality of cells of the erythroid lineage (HP:0012130)1.88918719
82Generalized aminoaciduria (HP:0002909)1.88221240
83Palpitations (HP:0001962)1.87016383
84Sclerocornea (HP:0000647)1.85863686
85Pancreatic cysts (HP:0001737)1.85829283
86Congenital primary aphakia (HP:0007707)1.85460926
87Delusions (HP:0000746)1.85074668
88Absent thumb (HP:0009777)1.84727191
89Molar tooth sign on MRI (HP:0002419)1.83642684
90Abnormality of midbrain morphology (HP:0002418)1.83642684
91Abnormal urine phosphate concentration (HP:0012599)1.82586362
92Cerebral inclusion bodies (HP:0100314)1.81070155
93Hyperventilation (HP:0002883)1.80261419
94Abnormality of placental membranes (HP:0011409)1.77179213
95Amniotic constriction ring (HP:0009775)1.77179213
96Absence seizures (HP:0002121)1.77038223
97Rib fusion (HP:0000902)1.75581800
98True hermaphroditism (HP:0010459)1.75577424
99Vomiting (HP:0002013)1.74243902
100Sparse eyelashes (HP:0000653)1.72952569
101Nephrogenic diabetes insipidus (HP:0009806)1.72104335
102Abnormality of serum amino acid levels (HP:0003112)1.71871151
103Triphalangeal thumb (HP:0001199)1.71001810
104Abnormality of the septum pellucidum (HP:0007375)1.70522436
105Dialeptic seizures (HP:0011146)1.69899169
106Vaginal atresia (HP:0000148)1.69363526
107Focal seizures (HP:0007359)1.68917519
108Poor suck (HP:0002033)1.68804679
109Epileptic encephalopathy (HP:0200134)1.68631956
110Exercise-induced myalgia (HP:0003738)1.67576006
111Blindness (HP:0000618)1.67307777
112Genital tract atresia (HP:0001827)1.66436525
113Partial duplication of thumb phalanx (HP:0009944)1.65903696
114Renal tubular dysfunction (HP:0000124)1.65683821
115Visual hallucinations (HP:0002367)1.65472386
116Maternal diabetes (HP:0009800)1.65342021
117Abnormal number of incisors (HP:0011064)1.65110061
118Stenosis of the external auditory canal (HP:0000402)1.65092922
119Abnormality of alanine metabolism (HP:0010916)1.64952189
120Hyperalaninemia (HP:0003348)1.64952189
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64952189
122Meckel diverticulum (HP:0002245)1.64153961
123Depressed nasal ridge (HP:0000457)1.63835962
124Abnormality of methionine metabolism (HP:0010901)1.63565629
125Pancytopenia (HP:0001876)1.63396875
126Birth length less than 3rd percentile (HP:0003561)1.61055706
127Progressive inability to walk (HP:0002505)1.60541399
128Progressive external ophthalmoplegia (HP:0000590)1.60109631
129Hypoplastic left heart (HP:0004383)1.59463509
130Gliosis (HP:0002171)1.58609946
131Cerebral hypomyelination (HP:0006808)1.58504355
132Muscle fiber splitting (HP:0003555)1.58202108
133Muscle stiffness (HP:0003552)1.58191649
134Megaloblastic anemia (HP:0001889)1.56243263
135Abnormal number of erythroid precursors (HP:0012131)1.56240195
136Abnormal protein glycosylation (HP:0012346)1.55064486
137Abnormal glycosylation (HP:0012345)1.55064486
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.55064486
139Abnormal protein N-linked glycosylation (HP:0012347)1.55064486
140Anophthalmia (HP:0000528)1.54618091
141Partial duplication of the phalanx of hand (HP:0009999)1.54125654
142Abnormality of the ileum (HP:0001549)1.53148920
143Abnormality of the calf musculature (HP:0001430)1.53027840
144Abnormal ciliary motility (HP:0012262)1.52547417
145Dicarboxylic aciduria (HP:0003215)1.51917830
146Abnormality of dicarboxylic acid metabolism (HP:0010995)1.51917830
147Respiratory insufficiency due to muscle weakness (HP:0002747)1.49701420
148Abnormal autonomic nervous system physiology (HP:0012332)1.47841754
149Delayed gross motor development (HP:0002194)1.47620230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.33556322
2CDC73.09597478
3STK393.06569498
4NME12.92219960
5MAP3K122.91306812
6ARAF2.59032191
7OXSR12.42418453
8CASK2.39467344
9SRPK12.32147594
10PNCK2.27944781
11ZAK2.26739599
12GRK52.18385436
13MYLK2.14462486
14GRK72.11722807
15MUSK2.00362094
16NEK11.98800890
17STK161.97675676
18WNK41.94341322
19BCR1.92514396
20NME21.83871489
21EPHA41.81645841
22LIMK11.76957727
23PLK31.75144504
24TAF11.72457943
25TNIK1.72443191
26TTK1.72279237
27OBSCN1.69883279
28MARK11.62881098
29UHMK11.61638806
30MAPKAPK51.60503591
31MAP2K71.58001893
32CDK191.55672298
33NUAK11.52826881
34MST41.52135745
35NTRK31.51105316
36PHKG21.48984454
37PHKG11.48984454
38ADRBK21.46913477
39CAMK2B1.46789339
40PBK1.45259187
41EIF2AK11.41233882
42PLK41.39332661
43FGR1.38584167
44MAP3K41.35260639
45CAMK2D1.33454415
46WEE11.30824852
47MAPK131.27481766
48CAMK2A1.27202645
49PKN11.22379303
50MAPK151.20483575
51PLK11.19094035
52BMPR1B1.17572005
53PLK21.16695944
54MKNK11.13888913
55NTRK11.12949183
56MINK11.11871442
57CAMK2G1.11235585
58CSNK1G31.10656941
59DYRK31.09462684
60BCKDK1.09221221
61TSSK61.07354545
62PINK11.05030580
63BMPR21.02278342
64DYRK21.02040861
65AURKB1.00379109
66CHEK21.00130481
67CDK80.99438302
68ADRBK10.97882595
69BRSK10.97775390
70MKNK20.95770868
71MAP4K20.93156506
72BRSK20.92751125
73ROCK20.92690543
74PRKCE0.90151079
75BRAF0.88157783
76VRK10.87782650
77CSNK2A20.87337634
78EPHB20.86998468
79AURKA0.86182650
80PIM20.85664733
81STK40.80565033
82PTK2B0.80301060
83GRK10.79398035
84MAP2K40.78636580
85DAPK30.76291980
86CDK50.74153931
87CSNK1G20.73996304
88CSNK2A10.73716145
89CDK140.73654705
90ABL20.73491469
91RIPK40.73489318
92TESK20.70965365
93NTRK20.70933573
94PASK0.70445033
95TRIM280.69994053
96CSNK1E0.69232705
97LRRK20.69094844
98RPS6KA50.68908658
99PIK3CA0.68803925
100PRKACA0.68591244
101WNK30.68562162
102MAP3K90.68086571
103LMTK20.66815005
104NEK20.65618052
105CDK180.65115644
106PRKCG0.65052119
107PAK30.64908431
108ATR0.64653017
109CSNK1G10.63161846
110INSRR0.62678275
111CDK150.62384960
112PDK40.62080818
113PDK30.62080818
114TESK10.61360262
115CCNB10.61313951
116ILK0.58775732
117CDK11A0.57873656
118EIF2AK30.55305062
119BUB10.54578535
120DAPK10.54267453
121TAOK20.53457774
122PRPF4B0.53447621
123MAP3K110.52512501
124TLK10.52410856
125NEK60.49285258
126FES0.48820093
127CSNK1A1L0.48453346
128PDK20.48394889
129PAK10.46626132
130WNK10.43842262
131IRAK20.41979087
132CHEK10.41794432
133EIF2AK20.41107490
134MAPK120.40571912
135MAPK40.39096606
136CAMKK20.39061517
137DAPK20.38921790
138SIK30.38746821
139CDK30.38164409
140CSNK1A10.38063173
141PRKG10.37719945
142DYRK1A0.37360507
143ATM0.36495085
144PRKCI0.34663764
145PRKACB0.34512006
146MAP2K10.33952759
147PRKCA0.33354981
148SGK2230.33281675

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.55628070
2Parkinsons disease_Homo sapiens_hsa050125.54256403
3Alzheimers disease_Homo sapiens_hsa050104.34183028
4Huntingtons disease_Homo sapiens_hsa050163.81621428
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.42130728
6Cardiac muscle contraction_Homo sapiens_hsa042603.22601221
7Ribosome_Homo sapiens_hsa030102.55948777
8Mismatch repair_Homo sapiens_hsa034302.47890656
9Proteasome_Homo sapiens_hsa030502.46732759
10DNA replication_Homo sapiens_hsa030302.41596462
11Collecting duct acid secretion_Homo sapiens_hsa049662.27244070
12Protein export_Homo sapiens_hsa030602.24244288
13Fatty acid elongation_Homo sapiens_hsa000622.22057732
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18475463
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10456153
16Homologous recombination_Homo sapiens_hsa034402.02117417
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01995978
18Spliceosome_Homo sapiens_hsa030401.91792329
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82007733
20Nicotine addiction_Homo sapiens_hsa050331.73181401
21Nucleotide excision repair_Homo sapiens_hsa034201.61244702
22Base excision repair_Homo sapiens_hsa034101.54417620
23Synaptic vesicle cycle_Homo sapiens_hsa047211.46958677
24Sulfur metabolism_Homo sapiens_hsa009201.46147602
25Vibrio cholerae infection_Homo sapiens_hsa051101.43775316
26One carbon pool by folate_Homo sapiens_hsa006701.39391412
27RNA degradation_Homo sapiens_hsa030181.32745609
28RNA polymerase_Homo sapiens_hsa030201.31200490
29Propanoate metabolism_Homo sapiens_hsa006401.29605561
30RNA transport_Homo sapiens_hsa030131.28951931
31Pyruvate metabolism_Homo sapiens_hsa006201.26495833
32Basal transcription factors_Homo sapiens_hsa030221.25554044
33Steroid biosynthesis_Homo sapiens_hsa001001.25003567
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20451321
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19580632
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18888822
37Fanconi anemia pathway_Homo sapiens_hsa034601.15530851
38GABAergic synapse_Homo sapiens_hsa047271.12861433
39Serotonergic synapse_Homo sapiens_hsa047261.12640177
40Butanoate metabolism_Homo sapiens_hsa006501.11080380
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01283970
42Taste transduction_Homo sapiens_hsa047420.99737635
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99572640
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92544118
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92117661
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90898920
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89719186
48Phototransduction_Homo sapiens_hsa047440.89408460
49Ether lipid metabolism_Homo sapiens_hsa005650.88036838
50Morphine addiction_Homo sapiens_hsa050320.85103663
51Non-homologous end-joining_Homo sapiens_hsa034500.84859891
52* Metabolic pathways_Homo sapiens_hsa011000.84149301
53Glutamatergic synapse_Homo sapiens_hsa047240.81725277
54Rheumatoid arthritis_Homo sapiens_hsa053230.80996625
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78221673
56Circadian entrainment_Homo sapiens_hsa047130.78140678
57Tyrosine metabolism_Homo sapiens_hsa003500.76518750
58Cell cycle_Homo sapiens_hsa041100.75274527
59Amphetamine addiction_Homo sapiens_hsa050310.74988358
60Biosynthesis of amino acids_Homo sapiens_hsa012300.74954089
61Dopaminergic synapse_Homo sapiens_hsa047280.69399086
62Phenylalanine metabolism_Homo sapiens_hsa003600.67567856
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67297075
64Arginine and proline metabolism_Homo sapiens_hsa003300.65492423
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63645817
66Carbon metabolism_Homo sapiens_hsa012000.61296249
67Olfactory transduction_Homo sapiens_hsa047400.61136834
68Cocaine addiction_Homo sapiens_hsa050300.60418494
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60148949
70Glutathione metabolism_Homo sapiens_hsa004800.59950640
71Renin secretion_Homo sapiens_hsa049240.58559458
72Calcium signaling pathway_Homo sapiens_hsa040200.58244493
73Fatty acid metabolism_Homo sapiens_hsa012120.57867918
74Peroxisome_Homo sapiens_hsa041460.56843835
75Histidine metabolism_Homo sapiens_hsa003400.54864824
76Linoleic acid metabolism_Homo sapiens_hsa005910.54825960
77Salivary secretion_Homo sapiens_hsa049700.54624406
78Long-term depression_Homo sapiens_hsa047300.53866176
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52758249
80Long-term potentiation_Homo sapiens_hsa047200.52715771
81Cholinergic synapse_Homo sapiens_hsa047250.51447790
82Selenocompound metabolism_Homo sapiens_hsa004500.50905810
83Insulin secretion_Homo sapiens_hsa049110.48168912
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46566437
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46403264
86Phagosome_Homo sapiens_hsa041450.45777867
87Basal cell carcinoma_Homo sapiens_hsa052170.45373328
88Arachidonic acid metabolism_Homo sapiens_hsa005900.44490558
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44233866
90Nitrogen metabolism_Homo sapiens_hsa009100.43974595
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.43595212
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39306941
93Tryptophan metabolism_Homo sapiens_hsa003800.38456885
94Pyrimidine metabolism_Homo sapiens_hsa002400.38028632
95Oocyte meiosis_Homo sapiens_hsa041140.37514536
96Gastric acid secretion_Homo sapiens_hsa049710.37498237
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36952333
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.36591865
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36044315
100Dilated cardiomyopathy_Homo sapiens_hsa054140.35404742
101Sphingolipid metabolism_Homo sapiens_hsa006000.34876940
102Regulation of autophagy_Homo sapiens_hsa041400.34450839
103Purine metabolism_Homo sapiens_hsa002300.34411578
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34149969
105mRNA surveillance pathway_Homo sapiens_hsa030150.34112503
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33214778
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31651072
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31470301
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30008684
110Hedgehog signaling pathway_Homo sapiens_hsa043400.29957414
111p53 signaling pathway_Homo sapiens_hsa041150.27035532
112Pancreatic secretion_Homo sapiens_hsa049720.26864247
113Oxytocin signaling pathway_Homo sapiens_hsa049210.26664945
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25989567
115Gap junction_Homo sapiens_hsa045400.25920505
116N-Glycan biosynthesis_Homo sapiens_hsa005100.25874315
117Folate biosynthesis_Homo sapiens_hsa007900.24647779
118Vitamin digestion and absorption_Homo sapiens_hsa049770.24531088
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24512620
120Fatty acid degradation_Homo sapiens_hsa000710.23396788
121Vitamin B6 metabolism_Homo sapiens_hsa007500.23185519
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.22761623
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21859663
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.21013599
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.20966077
126Axon guidance_Homo sapiens_hsa043600.20766446
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20448149
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20317145
129Galactose metabolism_Homo sapiens_hsa000520.20210475
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19830720
131Pentose phosphate pathway_Homo sapiens_hsa000300.19660819
132Retinol metabolism_Homo sapiens_hsa008300.18629846
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18002799
134beta-Alanine metabolism_Homo sapiens_hsa004100.17385652
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17292689
136Chemical carcinogenesis_Homo sapiens_hsa052040.16063449
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16027338
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.15714834
139Fructose and mannose metabolism_Homo sapiens_hsa000510.15387930
140Sulfur relay system_Homo sapiens_hsa041220.14956479
141African trypanosomiasis_Homo sapiens_hsa051430.14352544
142Alcoholism_Homo sapiens_hsa050340.13938995
143Arginine biosynthesis_Homo sapiens_hsa002200.13559054
144Fat digestion and absorption_Homo sapiens_hsa049750.13135858
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.12816346

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